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Global Biomarkers Industry Published on August 2011

Report Summary This report analyzes the worldwide markets for Biomarkers in US$ Million by the following Technologies and Services: Technologies Emerging Biomarker Technologies (Imaging biomarkers, Proteomics, Transcriptomics, & Bioinformatics), Conventional Biomarker Technologies - (Immunodiagnostics, & Molecular Diagnostics), and Others; Services - Clinical Biomarker Services, Specimen Preparation, and Bioinformatics and Others (miRNA Analysis and Others). The total market is also analyzed by the following Application Areas: Biomarker Discovery, Clinical Drug Development, and Diagnostics Techniques (Molecular). Key Therapeutic Areas also analyzed in the report include Oncology, Cardiology, CNS, and Others. The report provides separate comprehensive analytics for the US, Canada, Japan, Europe, Asia-Pacific, and Rest of World. Annual estimates and forecasts are provided for the period 2008 through 2017. The report profiles 204 companies including many key and niche players such as Abbott Laboratories, Affymetrix, Inc., Agilent Technologies, Inc., Alexion Pharmaceuticals, Beckman Coulter, Inc., Becton, Dickinson and Company, Bio-Rad Laboratories, Inc., BioMĂŠrieux, Bruker Corporation, Caprion Proteomics, Inc., Clarient Inc., Compugen, Ltd., Correlogic Systems, Inc., DiagnoCure, Inc., Epigenomics AG, GE Healthcare, Gene Logic, Genedata AG, Gen-Probe Inc., GlaxoSmithKline Plc, Hitachi Medical Corporation, Illumina, Inc., LabCorp., Life Technologies Corporation, Merck & Co. Inc., Metabolon, Inc., Myriad Genetics, Inc., Novartis International AG, Panacea Laboratories, Pfizer, Inc., Philips Healthcare, QIAGEN NV, Quest Diagnostic, Inc., Quest Diagnostics Company, Roche Diagnostics Corp., Rubicon Genomics, Inc., Rules-Based Medicine, Inc., and Siemens Healthcare Diagnostics, Inc. Market data and analytics are derived from primary and secondary research. Company profiles are mostly extracted from URL research and reported select online sources.

Table of Content

1. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS Study Reliability and Reporting Limitations Disclaimers

2

Data Interpretation & Reporting Level

2

Quantitative Techniques & Analytics

3

Product Definition and Scope of Study Definitions

3 4

Biomarker Technologies

4

Emerging Biomarker Technologies Proteomics Transcriptomics

4 4 5

Imaging biomarkers Bioinformatics

5 5

Conventional Biomarker Technologies Molecular Diagnostics

Global Biomarkers Industry (From Issuu)

1

1

5 5

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6

Other Biomarker Technologies

6

Metabolite and Enzyme Assays Reagents

6 6

Biomarker Services

6

Clinical Biomarker Services Biomarker Testing

6 6

Assay Development and Production

6

Antibody Development

7

Specimen Preparation

7

Bioinformatics and Others

7

2. INDUSTRY OVERVIEW

8

Global Biomarkers Market Surges in the Backdrop of Widening Medical Scope and Applications

8

Factors Engendering Positive Vibes

8

Factors Engendering Positive Influence on the Biomarkers Market: A Summary

9

Biomarkers: A Regional Perspective

9

US Spearheads the Global Biomarkers Market

9

US and Japan Take Lead on the Patent Front

10

Table 1: Dominance of US in the Global Biomarker Patent Filings (includes corresponding Graph/Chart)

10

Table 2: Leading Players in the Biomarkers Space by Number of Patent Filings (includes corresponding Graph/Chart)

11

Table 3: Number of Biomarker Patents Published and Filed: 2003-2007 (includes corresponding Graph/Chart)

11

Asia-Pacific: The Fastest Growing Biomarker Market

12

Supportive Governments and Regulatory Bodies to Fuel Growth

12

Increasing Collaborations Among Regulators and Companies Augur Well for Biomarkers

12

Player Strategies: An Insight

13

Table 4: Growing Number of Biomarker Deals (includes corresponding Graph/Chart)

13

Table 5: Competitive Strategy Mix in the Global Oncology Biomarkers Market (includes corresponding Graph/Chart)

14

Pharma and Biomarker Developer Tie-Ups to Raise Drug Development Productivity 3. MARKET OUTLOOK

14 15

Biomarkers: Evolving Scope and Applications

15

Technological Advancements - A Boon for Biomarker Discovery Evolving Role of Biomarkers in Drug Development Companion Biomarkers

15 16

16

Biomarkers Play Invaluable Role in Oncology and Cardiovascular

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16

Personalized Medicine- Revolutionizing the Medical Treatment

17

Biomarker-Led Drug Discovery - A Profitable Investment Technological Trends

18

18

Proteins Gain Upper Hand in Biomarkers

18

Mass Spectrometry - A Promising Technology in Molecular Medicine Market Restraints

18

19

Challenges in Biomarker Validation - A Major Growth Retardant The Road Ahead

19

19

Biomarkers to Witness Significant Growth in Therapeutic and Diagnostic Arenas

19

Efficiency Improvements Must for Realizing Cost-Effective Biomarker Testing

20

4. BIOMARKER TECHNOLOGIES AND SERVICES: AN OVERVIEW Biomarker - Definition & Introduction

21

21

BIOMARKER TECHNOLOGIES

21

EMERGING BIOMARKER TECHNOLOGIES Proteomics

21 22

Growth Drivers and Market Trends

22

Efficiency Gains in Drug Discovery Drive Growth in Proteomics

22

Proteomics Witness Increased Focus on Targeted Approach

22

Mass Spectrometry -Shifts in Focus to Proteomics Helps Biomarker Development

23

Mass Spectrometry Expands Scope of Protein Biomarker Applications

23

Transcriptomics

23

Transcriptomics - Assisting in Identification of Biomarkers

23

Imaging Biomarkers: Disease Diagnosis, the Non-Invasive way Types of Imaging Biomarkers - An Overview

24

24

Market Trends

25

Molecular Imaging - Gaining Importance in Drug Discovery and Development

25

Use of Molecular Imaging in Clinical Trials for Drug Development Bioinformatics

25 26

CONVENTIONAL BIOMARKER TECHNOLOGIES

26

Molecular Diagnostics

26

Immunodiagnostics

26

Market Trends

26

Growth in Use of Molecular Diagnostics to Propel Biomarker Growth

26

Demand for Novel Biomarkers Persists in Immunodiagnostics Immunoassays Plagued with Standardization Issues

27

OTHER BIOMARKER TECHNOLOGIES

27

Metabolite and Enzyme Assays Reagents Market Trends

Global Biomarkers Industry (From Issuu)

27

27 28 28

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28

Metabolomics Gain Rapid Foothold in Drug Discovery BIOMARKER SERVICES

28 28

Expanding Capabilities Drive Large-Scale Adoption

29

Clinical Biomarker Services

29

Biomarker Testing

29

Assay Development and Production

30

Antibody Development

30

Specimen Preparation

30

Bioinformatics and Other Biomarker Services

31

Bioinformatics Gain Prominence

31

miRNA Analysis

31

Microarray Services Witness Increasing Investments

31

5. BIOMARKERS MARKET BY APPLICATION

32

Role of Biomarkers in Drug Discovery and Development

32

Role of Biomarkers in Clinical Research and Patient Management Major Benefits of Biomarkers in Clinical Development

32

33

Major Benefits of Biomarkers in Medicine

33

Multifarious Applications of Biomarkers

33

New Applications Come to the Fore

33

Application of Biomarkers in Drug Development

34

Herceptin and Vilazodone -References for Success of Biomarker Based Approach

34

Increasing Role of Biomarkers in Modern Drug R&D

35

Translational Medicine Biomarkers Revolutionizing Drug Development Process

35

Outsourcing - Opportunities Galore

35

CROs in a Dilemma Over Investments in Biomarker Analysis Services

36

Lower Productivity of Traditional Drug Discovery Approach Calls for New Methods

36

Blockbuster Model Versus Personalized Medication Model

37

Workflow Standardization - Key to Success of Biomarkers in Drug Development

37

6. BIOMARKERS BY THERAPEUTIC AREA Current & Future Analysis ONCOLOGY

38 38 38

Factors Driving Oncology Biomarkers' Growth

38

US Remains at the Forefront of Cancer Biomarker Patent Filings

39

Table 6: Regional Split in the Global Cancer Biomarker Patent Filings: 2009 (includes corresponding Graph/Chart)

39

Table 7: Leading Players in Cancer Biomarkers by Number of Patent Filings: 2004-2009

39

Global Oncology Diagnostics and Drug Discovery Biomarkers Market

40

Table 8: World Recent Past, Current and Future Analysis for

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41

Table 9: World 10-Year Perspective for Oncology Biomarkers Market by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific and Rest of World Markets for Years 2008, 2011 and 2017 (includes corresponding Graph/Chart)

42

Table 10: Global Cancer Biomarkers Diagnostics (Molecular) Market by Company (2009): Market Share Breakdown of Revenues for Roche, Gen-Probe, Myriad, Abbott, QIAGEN and Others (includes corresponding Graph/Chart)

43

Evolution of Oncology Biomarkers

43

Available and Pipeline Biomarkers in Various Cancers

44

Breast Cancer Dominates Cancer Biomarkers Pipeline

44

Table 11: Global Cancer Biomarkers Pipeline by Indication (2010): Percentage Share Breakdown for Breast Cancer, Prostate Cancer, Colorectal Cancer, Ovarian Cancer, and Others (includes corresponding Graph/Chart)

45

Table 12: Global Oncology Biomarkers Market: Percentage Breakdown of Patent Filings by Oncology Area (2007)

45

Breast Cancer Market Awaits New Specific Biomarkers

45

Oncology Biomarker Diagnostic Techniques

46

Table 13: Leading Cancer Biomarker Diagnostic Technologies (2009): Percentage Share of Value Sales for Gene-based Markers, Proteomics, DNA Microarrays, Immunological Markers and IHC Tests, and Others (includes corresponding Graph/Chart)

46

Current Trends in Cancer Biomarkers

47

Validation Techniques Take Center Stage

47

Early-Stage Use of Biomarkers High in Oncology

47

Proteomics Ahead of Genomic Biomarkers in Functionality

48

Pharmacogenomics and IHC Tests Inch Ahead in Cancer Biomarker Diagnostics

48

Faster Diagnosis Benefits DNA Microarray Technology Other Tests Lose Market Share Companion Biomarkers in Oncology

49

CARDIOLOGY Market Trends

48 49

49 50

Increasing Health Burden Drives Research Efforts

50

Gene Expression Analysis Delivers Novel Therapeutic Approaches

50

High-Performance Techniques Drive Biomarker Discovery in Cardiology

Global Biomarkers Industry (From Issuu)

51

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51

Role of Linkage Analysis in Cardiovascular Biomarker Identification

51

Biomarkers of ACS

51

Biomarkers - A Promising Diagnostic Tool for ACS

52

Biomarker Discovery in Cardiovascular Diseases to Undergo Significant Changes

52

Major Cardiovascular Diagnostic Biomarkers - A Focus on Biomarkers for ACS

53

Creatine Kinase-Myocardial Band

53

Natriuretic Peptides

53

Cardiac Troponin Myoglobin

53 53

New Diagnostic Biomarkers for ACS on the Anvil

54

Genomic Biomarkers for Detecting Cardiovascular Diseases Growing Demand for Stroke Biomarkers

54 55

Rising Incidence of the Disease - A Major Driver for Stroke Biomarkers

55

CENTRAL NERVOUS SYSTEM (CNS)

55

Lower Commercial Availability Restricts Market Share

56

Research Efforts Remain Confined to Specific Areas

56

High Cost of Treatment Shadows Biomarkers' Short-Treatment Benefits

56

Research Methodology in CNS Biomarkers

56

Alliances - A Key Aspect to the Development of CNS Biomarkers Biomarkers in Select CNS Diseases

57

57

Alzheimer's Disease

57

Parkinson's Disease Biomarkers - Crucial for Neuroprotectants' Effectiveness

58

Schizophrenia: An Unexploited Segment

58

OTHER THERAPEUTIC AREAS

58

Inflammatory and Autoimmune Disorders

58

Biomarkers offer Efficient Diagnosis and Treatment Rheumatology

59

59

7. AN OVERVIEW OF SELECT BIOMARKERS

60

HER2/neu/ ErbB2 Gene

60

HER2 and its Association with Cancer

60

Target Drugs for HER2

60

Hepsin Biomarkers

60

Early Prostate Cancer Antigen-2 MMP-3 ImmunoCyt'/uCyt+' AmpliChip CYP450 Test

60 61 61 62

The OncoVue速 Breast Cancer Risk Test Oncotype DX速 Test Oncotype DX Colon Cancer Assay

Global Biomarkers Industry (From Issuu)

62 62 63

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63

Theros CancerTYPE ID

63

PgxPredict:CLOZAPINE- Test for Qualifying Patients to Use Clozapine

63

The Pathwork Tissue of Origin Test

64

PROGENSA PCA3 Assay

64

Epi proColon® Early Detection Assay

64

OVA1® Test

65

Bcr-abl Fusion Protein

65

HLA-B

65

Mammostrat®

65

Ipsogen MapQuant Dx' Genomic Grade

66

CA1-18 Enzyme Immunoassay (EIA)

66

Anti-L523S Antibody

66

8. PRODUCT INTRODUCTIONS IN THE BIOMARKERS SPACE

67

RBM Unveils OncologyMAP® Panel of 101 Quantitative Biomarker Tests

67

Avantra Introduces New BioChip Immunoassay Biomarker Workstation Clarient Introduces Mammostrat Test

67

67

Biomagnetics Diagnostics Identifies Second Biomarker for Tuberculosis Assay

68

Epistem Introduces Novel Ex Vivo Plucked Hair Biomarker Assay

68

Crescendo Bioscience Launches New Multi Biomarker Blood Test

68

Alere International Launches New Triage® NT-proBNP Test

68

Agilent Technologies Launches New SureSelect Kinome Target Enrichment Kit

69

Roche Diagnostics to Launch New STAT Immunoassays

69

Gentel Biosciences Launches New Human Profiling Kits

69

QIAGEN Introduces QIAsymphony RGQ System

70

Almac Introduces Biomarkers for Biopharmaceutical Industry i-Path Introduces TMA Toolbox

70

71

Abbott Introduces ARCHITECTPLUS Systems

71

Affymetrix Introduces QuantiGene® ViewRNA Assayformats

72

ARUP Laboratories Introduces New Test for Colorectal Caner Detection

72

Warnex Launches Blood Testing Service for Colorectal Cancer in Canada

72

Agilent Technologies Launches mAb-Glyco-Chip

73

synlab Launches Septin9 Testing in Germany

73

IDBS Introduces New Biomarker Discovery and Validation Solution

73

Quest Diagnostics Introduces Blood Test for Detecting Colorectal Cancer

74

Clarient Introduces Biomarker Panel for NSCLC Classification

74

Institute of Microelectronics and Agency for Science, Technology and Research Launch Rapid Cardiac Biomarker Test Rules-Based Medicine Unveils CardiovascularMAP' for CVD Treatment Thermo Fisher Introduces New Copeptin Assay

Global Biomarkers Industry (From Issuu)

74 75

75

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75

Genedata Unveils Genedata Expressionist® 5.3

75

Arrayit Introduces Biomarker Discovery Service

76

Invitrogen Introduces Biomarker Tool for Kidney Function Research Abbott Introduces ARCHITECT® c4000®

76

76

Epigenomics Rolls Out Epi proColon Range in Europe

77

Genedata Introduces Expressionist 5.2 for Identifying MS-based Biomarker

77

VisEn Unveils FAST - A Novel Imaging Platform

77

Millipore and CXR Biosciences Unveils ToxReporter'

78

Rules-Based Medicine Unveils Human Kidney Multi-Analyte Profile

78

MDS and Applied Biosystems Launch AB SCIEX TOF/TOF' 5800 System Genetic Biomarkers for Chronic Kidney Disease

78

79

Bruker Launches Advanced MALDI-TOF/TOF Mass Spectrometer Satoris Introduces three Novel Blood Tests

79

79

GE Healthcare Launches Discovery' MR450

79

GE Healthcare in Partnership with Varian Launches Discovery MR901 (US)

80

Applied Biosystems and MDS Analytical Launches Novel New Mass Spectrometry Tools

80

Rules-Based Medicine Commercializes Rat Kidney MAP Biomarker Panel

80

Thomson Reuters Introduces BIOMARKERcenter

81

Gentel® Biosciences Introduces SilverQuant' GlycoBiomarker Array Kit

81

BioMarker Pharmaceuticals Introduces Gene Essence' DNA Test mtm laboratories Introduces Cervatec' Assay

82

82

Decision Biomarkers Introduces AVANTRA Biomarker Workstation

82

Aureon Introduces Prostate Px® to Predict Progression and Recurrence of Prostrate cancer

83

VisEn Introduces a Novel Imaging Agent

83

9. BIOMARKERS M&A ACTIVITY

84

QIAGEN to Take Over Stake in Alacris Theranostics

84

Transgenomic Acquires Certain Businesses of Clinical Data

84

Caliper Life Sciences Acquires Cambridge Research & Instrumentation

84

Biosystems International and MicroBioChips Merge Axela Takes Over Xceed Molecular

85 85

Accelrys Merges with Symyx Technologies

85

Caprion Proteomics Acquires PPD's Biomarker Division

86

QIAGEN Takes Over SABiosciences

86

Thermo Fisher Scientific Takes Over Brahms QIAGEN Takes Over DxS ICON Takes Over Veeda Laboratories

86 87 87

ID Business Solutions Takes Over InforSense

87

Clinical Data Acquires Avalon Pharmaceuticals

88

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88

Oxford Gene Technology Takes Over Sense Proteomic

88

Tethys Bioscience Takes Over Lipomics Technologies

88

QPS LLC Acquires Bio-Kinetic Clinical Applications

89

AltheaDx Rolls Out Affymetrix DMET Genotyping Microarray Service 10. COLLABORATIONS AND AGREEMENTS

89 90

Proteome Sciences Bags Contract from Eisai

90

MDxHealth to Ink Partnership Agreement with Pfizer, Cancer Research Technology and Newcastle University

90

Takeda and Zinfandel Enter into License Agreement for AD Biomarker

90

Pacific Biomarkers Forges Research Deals with Two Multinational Firms

90

SMA Foundation and RBM Partner to Develop Panel of SMA Biomarker

91

Epigenomics Enters into Collaboration with QIAGEN to Develop Colorectal Cancer Blood Tests

91

Vermillion Inks Agreement with Quest to Launch OVA1速 in India

91

DiaGenic and Pfizer Team Up for Identifying Biomarkers for AD

92

Prometheus Signs Agreement with The Regents of the University of California

92

Aushon BioSystems Enters into Partnership with LightArray Biotech GE Healthcare Collaborates with Johnson & Johnson

92

93

ICON Enters into Strategic Alliance with Proteome Sciences

93

Epigenomics Inks Distribution Agreement with DATEKS

93

Epigenomics Inks Distribution Agreement with Pronto Diagnostics Thermo Fisher Collaborates with Proteome Sciences

93

94

Diaceutics Teams Up with London Genetics to Develop Software Decision Tools

94

OncoMethylome Enters Into Agreement with GlaxoSmithKline Biologicals

94

SureGene Enters into Research Collaboration with Medco Research Institute

95

Ariadne Inks Agreement with Roswell Park Cancer Institute and Cellecta

95

SDIX Enters into Multi-Year Collaboration with Banyan Biomarkers Roche Acquires Co-exclusive License from QIAGEN

96

96

Metabolon Collaborates with Colgate-Palmolive for Periodontal Disease Biomarkers Identification

96

Toscana Biomarkers and Regione Toscana Enter into Grant Agreement ACC and Roche Diagnostics Initiate Collaboration

96

97

Epigenomics Inks Distribution Agreement with DPC LEBANON

97

Duke Enters into Joint Venture with LabCorp for Biomarker Commercialization

97

HDC and SPM Enter Into Agreement with Quest Diagnostics Toscana Biomarkers Collaborates with QuantiScientifics

98 98

Intrinsic Bioprobes Licenses New Biomarkers to Ortho-Clinical Diagnostics

Global Biomarkers Industry (From Issuu)

98

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99

PAREXEL Enters into Partnership with Proteome Sciences

99

Biocartis Inks Agreement with Royal Philips Electronics

99

QIAGEN Signs Agreement with Wuxi AppTec

100

SDIX Enters into Collaboration with Fred Hutchinson Cancer Research Center

100

Siemens Teams UP with EDPL to Institute Cyclotron Facility in India

100

ALS TDI Concluded First Phase of Collaboration with Applied Proteomics

101

Psynova Neurotech Teams Up with Roche for Schizophrenia Treatment Development

101

Minerva Biotechnologies Licenses Exclusive Marketing Rights to Clarient

102

Rules-Based Medicine Signs Biomarker-Driven Agreement with Covance

102

BG Medicine and Abbott Ink Agreement for galectin-3 Biomarker Epigenomics and ARUP Ink Non-Exclusive Agreement

102 102

Biosystems International Signs Licensing Agreement with Lohocla Research

102

Axela Signs Agreements with Micromedics and Proteome Sciences

103

Moffitt Cancer Center and Frantz BioMarkers Enter into Licensing Agreement

103

Fujirebio Diagnostics Signs Agreement with BD for Oncology Diagnostic Assays

104

Quest Diagnostics Bags Prostrate Cancer Test License from Epigenomics

104

Genedata Extends Collaboration Agreement with Roche

104

BioTheranostics Inks Commercialization Agreement with Lab 21 for THEROS CancerTYPE ID

104

Researchers Utilizes AB Sciex Qtrap 5500 System to Detect Biomarkers

105

Fujirebio Inks Agreement with Abbott to Develop Ovarian Cancer Test

105

Caprion and Applied Bioystems Partners to Accelerate Validation and Verification of Protein Biomarker

105

Sysmex Inks Research Partnership Deal with Epigenomics Pharsight Inks Agreement with InforSense

106 106

AstraZeneca and Washington University Team Up to Develop Novel Methods for Alzheimer's Disease Diagnosis and Treatment 11. OTHER CORPORATE INITIATIVES IN BIOMARKERS SPACE

106 107

Genedata Installs Genedata Expressionist速 Refiner MS at Victoria DPI

107

Genedata Deploys Genedata Expressionist速 at Hospital for Sick Children

107

Covance Establishes New Unit for Discovery and Translation Services

Global Biomarkers Industry (From Issuu)

107

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107

PMDA Accepts Biomarker Panel of Critical Path's

107

Clarient Obtains UK Patents for the TLE3 Biomarker

108

Agilent Supplies Mass Spectrometry Devices to Stemina Biomarker Discovery

108

Pacific Biomarkers to Launch New Logo, Marketing and Branding Initiatives

108

SMA Foundation Completes Biomarker Study

108

Genedata Offers Genedata Expressionist® to RIKEN

109

Chronix Biomedical Strengthens Biomarker Development Capabilities Aureon Changes Name of Colorectal Cancer Prognostic Test

109

109

Satoris Gains Global Distribution Rights to RBM's DiscoveryMAP' Panel

109

Teva Pharmaceutical Industries to Use Biomarkers of Compugen

110

Genedata Provides Genedata Expressionist® System to Asubio Pharma InforSense Aids Biomarker Discovery Process by Celera

110

Xennex Provides Satoris with Access to GeneCards®

111

IME Developed Silicon-Based Testing System for Cardiac Biomarkers 12. FOCUS ON SELECT GLOBAL PLAYERS 112 112

Agilent Technologies, Inc. (US)

113

Alexion Pharmaceuticals, Inc. (USA)

113

Beckman Coulter, Inc. (US)

114

Becton, Dickinson and Company (US)

114

Bio-Rad Laboratories, Inc. (US) BioMérieux (France)

115 115

Bruker Corporation (US)

115

Caprion Proteomics, Inc. (Canada) Clarient Inc. (US) Compugen, Ltd. (Israel)

116 117 117

Correlogic Systems, Inc. (US)

117

DiagnoCure, Inc. (Canada)

117

Epigenomics AG (Germany) GE Healthcare (UK) Gene Logic (US)

118 118 119

Genedata AG (Switzerland) Gen-Probe Inc. (US)

119 119

GlaxoSmithKline Plc. (UK)

120

Hitachi Medical Corporation (Japan)

120

Illumina, Inc. (US)

121

LabCorp. (US)

121

Life Technologies Corporation (US)

122

Merck & Co., Inc. (US)

122

Metabolon, Inc. (US)

122

Myriad Genetics, Inc. (US) Novartis International AG (Switzerland)

Global Biomarkers Industry (From Issuu)

111

112

Abbott Laboratories (US) Affymetrix, Inc. (US)

110

123 123

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124 124

Philips Healthcare (Netherlands)

125

QIAGEN NV (The Netherlands)

125

Quest Diagnostic, Inc. (US)

125

Roche Diagnostics Corp. (US)

126

Rubicon Genomics, Inc. (US)

126

Rules-Based Medicine, Inc. (US)

126

Siemens Healthcare Diagnostics, Inc. (US)

127

13. GLOBAL MARKET PERSPECTIVE

128

Table 14: World Recent Past, Current and Future Analysis for Biomarkers by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2008 through 2017 (includes corresponding Graph/Chart)

128

Table 15: World 10-Year Perspective for Biomarkers by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific and Rest of World Markets for Years 2008, 2011 and 2017 (includes corresponding Graph/Chart)

129

Table 16: World Recent Past, Current and Future Analysis for Biomarker Technologies by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2008 through 2017 (includes corresponding Graph/Chart)

130

Table 17: World 10-Year Perspective for Biomarker Technologies by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific and Rest of World Markets for Years 2008, 2011 and 2017 (includes corresponding Graph/Chart)

131

Table 18: World Recent Past, Current and Future Analysis for Biomarker Technologies by Segment - Emerging Biomarker Technologies, Conventional Biomarker Technologies, and Other Biomarker Technologies Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2008 through 2017 (includes corresponding Graph/Chart)

132

Table 19: World 10-Year Perspective for Biomarker Technologies by Segment - Percentage Breakdown of Dollar Sales for Emerging Biomarker Technologies, Conventional Biomarker Technologies, and Other Biomarker Technologies Markets for Years 2008, 2011 and 2017 (includes corresponding Graph/Chart)

Global Biomarkers Industry (From Issuu)

132

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133

Table 21: World 10-Year Perspective for Emerging Biomarker Technologies by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific and Rest of World Markets for Years 2008, 2011 and 2017 (includes corresponding Graph/Chart)

134

Table 22: World Recent Past, Current and Future Analysis for Emerging Biomarker Technologies by Segment - Imaging biomarkers, Proteomics, Transcriptomics, and Bioinformatics Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2008 through 2017 (includes corresponding Graph/Chart)

135

Table 23: World 10-Year Perspective for Emerging Biomarker Technologies by Segment - Percentage Breakdown of Dollar Sales for Imaging biomarkers, Proteomics, Transcriptomics, and Bioinformatics Markets for Years 2008, 2011 and 2017 (includes corresponding Graph/Chart)

135

Table 24: World Recent Past, Current and Future Analysis for Imaging Biomarkers by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2008 through 2017 (includes corresponding Graph/Chart)

136

Table 25: World 10-Year Perspective for Imaging Biomarkers by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific and Rest of World Markets for Years 2008, 2011 and 2017 (includes corresponding Graph/Chart)

137

Table 26: World Recent Past, Current and Future Analysis for Proteomics in Biomarkers Market by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2008 through 2017 (includes corresponding Graph/Chart)

138

Table 27: World 10-Year Perspective for Proteomics in Biomarker Market by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific

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139

Table 28: World Recent Past, Current and Future Analysis for Transcriptomics in Biomarkers Market by Geographic Region US, Canada, Japan, Europe, Asia-Pacific and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2008 through 2017 (includes corresponding Graph/Chart)

140

Table 29: World 10-Year Perspective for Transcriptomics in Biomarkers Market by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific and Rest of World Markets for Years 2008, 2011 and 2017 (includes corresponding Graph/Chart)

141

Table 30: World Recent Past, Current and Future Analysis for Bioinformatics in Biomarkers Market by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2008 through 2017 (includes corresponding Graph/Chart)

142

Table 31: World 10-Year Perspective for Bioinformatics in Biomarkers Market by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific and Rest of World Markets for Years 2008, 2011 and 2017 (includes corresponding Graph/Chart)

143

Table 32: World Recent Past, Current and Future Analysis for Conventional Biomarker Technologies by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2008 through 2017 (includes corresponding Graph/Chart)

144

Table 33: World 10-Year Perspective for Conventional Biomarker Technologies by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific and Rest of World Markets for Years 2008, 2011 and 2017 (includes corresponding Graph/Chart)

145

Table 34: World Recent Past, Current and Future Analysis for Conventional Biomarker Technologies by Segment Immunodiagnostics and Molecular Diagnostics Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2008 through 2017 (includes corresponding Graph/Chart)

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>> Get this Report Now by email! Table 35: World 10-Year Perspective for Conventional Biomarker Technologies by Segment - Percentage Breakdown of Dollar Sales for Immunodiagnostics and Molecular Diagnostics Markets for Years 2008, 2011, and 2017 (includes corresponding Graph/Chart)

146

Table 36: World Recent Past, Current and Future Analysis for Immunodiagnostics by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2008 through 2017 (includes corresponding Graph/Chart)

147

Table 37: World 10-Year Perspective for Immunodiagnostics by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific and Rest of World Markets for Years 2008, 2011 and 2017 (includes corresponding Graph/Chart)

148

Table 38: World Recent Past, Current and Future Analysis for Molecular Diagnostics by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2008 through 2017 (includes corresponding Graph/Chart)

149

Table 39: World 10-Year Perspective for Molecular Diagnostics by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific and Rest of World Markets for Years 2008, 2011 and 2017 (includes corresponding Graph/Chart)

150

Table 40: World Recent Past, Current and Future Analysis for Other Biomarker Technologies by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2008 through 2017 (includes corresponding Graph/Chart)

151

Table 41: World 10-Year Perspective for Other Biomarker Technologie by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific and Rest of World Markets for Years 2008, 2011 and 2017 (includes corresponding Graph/Chart)

152

Table 42: World Recent Past, Current and Future Analysis for Biomarker Services by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years

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153

Table 43: World 10-Year Perspective for Biomarker Services by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific and Rest of World Markets for Years 2008, 2011 and 2017 (includes corresponding Graph/Chart)

154

Table 44: World Recent Past, Current and Future Analysis for Biomarker Services by Segment- Clinical Biomarker Services, Specimen Preparation, and Other Biomarker Services Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2008 through 2017 (includes corresponding Graph/Chart)

155

Table 45: World 10-Year Perspective for Biomarker Services by Segment - Percentage Breakdown of Dollar Sales for Clinical Biomarker Services, Specimen Preparation, and Other Biomarker Services Markets for Years 2008, 2011 and 2017 (includes corresponding Graph/Chart)

155

Table 46: World Recent Past, Current and Future Analysis for Clinical Biomarker Services by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2008 through 2017 (includes corresponding Graph/Chart)

156

Table 47: World 10-Year Perspective for Clinical Biomarker Services by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific and Rest of World Markets for Years 2008, 2011 and 2017 (includes corresponding Graph/Chart)

157

Table 48: World Recent Past, Current and Future Analysis for Specimen Preparation by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2008 through 2017 (includes corresponding Graph/Chart)

158

Table 49: World 10-Year Perspective for Specimen Preparation by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific and Rest of World Markets for Years 2008, 2011 and 2017 (includes corresponding Graph/Chart)

159

Table 50: World Recent Past, Current and Future Analysis for Other Biomarker Services by Geographic Region - US, Canada,

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160

Table 51: World 10-Year Perspective for Other Biomarker Services by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific and Rest of World Markets for Years 2008, 2011 and 2017 (includes corresponding Graph/Chart)

161

Table 52: World Recent Past, Current and Future Analysis for Biomarkers by Application - Biomarker Discovery, Clinical Drug Development, and Diagnostics Techniques (Molecular) Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2008 through 2017 (includes corresponding Graph/Chart)

162

Table 53: World 10-Year Perspective for Biomarkers by Application - Percentage Breakdown of Dollar Sales for Biomarker Discovery, Clinical Drug Development, and Diagnostics Techniques (Molecular) Markets for Years 2008, 2011 and 2017 (includes corresponding Graph/Chart)

162

Table 54: World Recent Past, Current and Future Analysis for Biomarkers by Therapeutic Area - Cancer Biomarkers, Cardiology Biomarkers, CNS Biomarkers, and Other Therapeutic Biomarker Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2008 through 2017 (includes corresponding Graph/Chart)

163

Table 55: World 10-Year Perspective for Biomarkers by Therapeutic Area - Percentage Breakdown of Dollar Sales for Cancer Biomarkers, Cardiology Biomarkers, CNS Biomarkers, and Other Therapeutic Biomarker Markets for Years 2008, 2011 and 2017 (includes corresponding Graph/Chart)

164

14. THE UNITED STATES A.Market Analysis Current & Future Analysis

165 165 165

Companies Wake Up to the Growing Need for Effective Biomarkers Biomarker Regulations in the US Product Launches

166 166

Strategic Corporate Developments

176

Focus on Select Major Players B.Market Analytics

165

189 201

Table 56: The US Recent Past, Current and Future Analysis for Biomarkers by Segment-Biomarker Technologies [Emerging

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>> Get this Report Now by email! Biomarker Technologies (Imaging Biomarkers, Proteomics, Transcriptomics and Bioinformatics), Conventional Biomarker Technologies (Immunodiagnostics and Molecular Diagnostics) and Others] and Biomarker Services [Clinical Biomarker Services, Specimen Preparation and Others] Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2008 through 2017 (includes corresponding Graph/Chart)

201

Table 57: The US 10-Year Perspective for Biomarkers by Segment - Percentage Breakdown of Dollar Sales for Biomarker Technologies [Emerging Biomarker Technologies (Imaging Biomarkers, Proteomics, Transcriptomics and Bioinformatics), Conventional Biomarker Technologies (Immunodiagnostics and Molecular Diagnostics) and Others] and Biomarker Services [Clinical Biomarker Services, Specimen Preparation and Others] Markets for Years 2008, 2011 and 2017 (includes corresponding Graph/Chart) 15. CANADA A.Market Analysis

203 204 204

Current & Future Analysis Product Launch

204 204

Strategic Corporate Developments

204

Focus on Select Major Players B.Market Analytics

206 207

Table 58: Canadian Recent Past, Current and Future Analysis for Biomarkers by Segment- Biomarker Technologies [Emerging Biomarker Technologies (Imaging Biomarkers, Proteomics, Transcriptomics and Bioinformatics), Conventional Biomarker Technologies (Immunodiagnostics and Molecular Diagnostics) and Others] and Biomarker Services [Clinical Biomarker Services, Specimen Preparation and Others] Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2008 through 2017 (includes corresponding Graph/Chart)

207

Table 59: Canadian 10-Year Perspective for Biomarkers by Segment - Percentage Breakdown of Dollar Sales for Biomarker Technologies [Emerging Biomarker Technologies (Imaging Biomarkers, Proteomics, Transcriptomics and Bioinformatics), Conventional Biomarker Technologies (Immunodiagnostics and Molecular Diagnostics) and Others] and Biomarker Services [Clinical Biomarker Services, Specimen Preparation and Others] Markets for Years 2008, 2011 and 2017 (includes corresponding Graph/Chart) 16. JAPAN

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210

Current & Future Analysis

210

Strategic Corporate Developments

210

Hitachi Medical Corporation - A Key Player B.Market Analytics

211 212

Table 60: Japanese Recent Past, Current and Future Analysis for Biomarkers by Segment- Biomarker Technologies [Emerging Biomarker Technologies (Imaging Biomarkers, Proteomics, Transcriptomics and Bioinformatics), Conventional Biomarker Technologies (Immunodiagnostics and Molecular Diagnostics) and Others] and Biomarker Services [Clinical Biomarker Services, Specimen Preparation and Others] Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2008 through 2017 (includes corresponding Graph/Chart)

212

Table 61: Japanese 10-Year Perspective for Biomarkers by Segment - Percentage Breakdown of Dollar Sales for Biomarker Technologies [Emerging Biomarker Technologies (Imaging Biomarkers, Proteomics, Transcriptomics and Bioinformatics), Conventional Biomarker Technologies (Immunodiagnostics and Molecular Diagnostics) and Others] and Biomarker Services [Clinical Biomarker Services, Specimen Preparation and Others] Markets for Years 2008, 2011 and 2017 (includes corresponding Graph/Chart) 17. EUROPE A.Market Analysis

214 215 215

Current & Future Analysis

215

Biopharmaceutical Industry Tunes into Biomarker- Based Drug R&D Biomarker Regulations in Europe

215

215

EMEA's Experience in Pharmacogenetic Drugs - Still Nascent

216

Uncertain Laws Discourage VC Funding in Europe

216

Uncertainty Continues Among Regulators over Biomarker Validation Levels B.Market Analytics

216 217

Table 62: European Recent Past, Current and Future Analysis for Biomarkers by Geographic Region - France, Germany, Italy, UK and Rest of Europe Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2008 through 2017 (includes corresponding Graph/Chart)

217

Table 63: European 10-Year Perspective for Biomarkers by Geographic Region - Percentage Breakdown of Dollar Sales for France, Germany, Italy, UK and Rest of Europe Markets for Years 2008, 2011 and 2017 (includes corresponding Graph/Chart)

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>> Get this Report Now by email! Table 64: European Recent Past, Current and Future Analysis for Biomarkers by Segment- Biomarker Technologies [Emerging Biomarker Technologies (Imaging Biomarkers, Proteomics, Transcriptomics and Bioinformatics), Conventional Biomarker Technologies (Immunodiagnostics and Molecular Diagnostics) and Others] and Biomarker Services [Clinical Biomarker Services, Specimen Preparation and Others] Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2008 through 2017 (includes corresponding Graph/Chart)

219

Table 65: European 10-Year Perspective for Biomarkers by Segment - Percentage Breakdown of Dollar Sales for Biomarker Technologies [Emerging Biomarker Technologies (Imaging Biomarkers, Proteomics, Transcriptomics and Bioinformatics), Conventional Biomarker Technologies (Immunodiagnostics and Molecular Diagnostics) and Others] and Biomarker Services [Clinical Biomarker Services, Specimen Preparation and Others] Markets for Years 2008, 2011 and 2017 (includes corresponding Graph/Chart) 17a. FRANCE A.Market Analysis

221 222 222

Current & Future Analysis

222

Strategic Corporate Development

222

BioMĂŠrieux (France) - A Key Player B.Market Analytics

222 223

Table 66: French Recent Past, Current and Future Analysis for Biomarkers by Segment- Biomarker Technologies [Emerging Biomarker Technologies (Imaging Biomarkers, Proteomics, Transcriptomics and Bioinformatics), Conventional Biomarker Technologies (Immunodiagnostics and Molecular Diagnostics) and Others] and Biomarker Services [Clinical Biomarker Services, Specimen Preparation and Others] Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2008 through 2017 (includes corresponding Graph/Chart)

223

Table 67: French 10-Year Perspective for Biomarkers by Segment - Percentage Breakdown of Dollar Sales for Biomarker Technologies [Emerging Biomarker Technologies (Imaging Biomarkers, Proteomics, Transcriptomics and Bioinformatics), Conventional Biomarker Technologies (Immunodiagnostics and Molecular Diagnostics) and Others] and Biomarker Services [Clinical Biomarker Services, Specimen Preparation and Others] Markets for Years 2008, 2011 and 2017 (includes corresponding Graph/Chart)

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226 226 226 226

Strategic Corporate Development

227

Epigenomics AG - A Key Player

227

B.Market Analytics

228

Table 68: German Recent Past, Curr

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Global Biomarkers Industry  

This report analyzes the worldwide markets for Biomarkers in US$ Million by the following Technologies and Services: Technologies - Emerging...

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