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Colorectal Cancer Drug Pipeline Update 2011 Published on February 2011

Report Summary Until a decade ago, 5FU/leucovorin formed the mainstay of colorectal cancer treatment but Camptosar and Eloxatin quickly established themselves as components of gold-standard therapy. The advent of Avastin and Erbitux heralded a new era in the disease management, and the emergence of other molecular targeted agents should further push survival to an unprecedented level in the coming years. There are today 297 (270) companies plus partners developing 377 (317) drugs targeting colorectal cancer in development. In addition, there are 5 (5) suspended drugs and the accumulated number of ceased drugs over the last years amount to another 145 (141) drugs. Colorectal Cancer Drug Pipeline Update lists all drugs and gives you a progress analysis on each one of them. Identified drugs are linked to 210 (187) different targets. These targets are further categorized on in the software application by 63 (58) classifications of molecular function and with pathway referrals to BioCarta, KEGG and NetPath. Figures in brackets are comparative data from last year. Find and sort drugs by twelve different parameters plus free text search field. Our dynamic report generator lets you with ease and speed generate html reports directly in your web browser, whether it is a single drug profile or an entire search you want have a report of. How May Drug Pipeline Update Be of Use' * Show investors/board/management that you are right on top of drug development progress in your therapeutic area. * Find competitors, collaborations partners, M&A candidates etc. * Jump start competitive drug intelligence operations * Excellent starting point for world wide benchmarking * Compare portfolio and therapy focus with your peers * Speed up pro-active in-/out licensing strategy work * Fast and easy way of tracking drugs using search engines; just one click from inside the application and you may search the World Wide Web and PubMed for any drug. Drug Pipeline Update is delivered to you as a downloadable application, which requires no installation on your computer. Please read more about application features and system requirements below. Drug Pipeline Update at a Glance Investigators Includes more than 297 (270) principal investigators plus their collaborators. There is direct access from inside the application to web pages of all principal investigators. Note: You are able to sort and find drugs according to investigators and partners from drop-down menus in the application. You may also sort and find drugs according to country of investigator. Drug name & Synonyms Lists commercial, generic and code names for drugs.

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>> Get this Report Now by email! Developmental stage This Drug Pipeline Update contains 377 (317) drugs in development for the treatment of colorectal cancer. In addition there are suspended and ceased drugs. Pipeline Breakdown According to Number of Drugs Marketed# 15 (15) Registered# 0 (1) Pre-registration# 1 (1) Phase III# 19 (9) Phase II# 137 (111) Phase I# 103 (85) Preclinical# 101 (78) No Data# 1 (17) Suspended# 5 (5) Ceased# 145 (141) Note: You are able to sort and find drugs according to developmental stage from drop-down menu in the application. Indications Included colorectal cancer drugs are also in development for 188 (162) other indications, where of 77 (73) are different cancer indications. Note: You are able to find and sort drugs according to type of indication from drop-down menu in the application. Targets Identified drugs are linked to more than 210 (187) different targets, divided into 63 (58) classifications of molecular function: - ATPase activity - Auxiliary transport protein activity - Carboxy-lyase activity - Catalytic activity - Cell adhesion molecule activity - Chaperone activity - Cofactor binding - Complement activity - Cysteine-type peptidase activity - Cytokine activity - Deacetylase activity - DNA binding - DNA repair protein - DNA topoisomerase activity - DNA-directed DNA polymerase activity - DNA-methyltransferase activity - Extracellular ligand-gated ion channel activity - Extracellular matrix structural constituent - G-protein coupled receptor activity - Glutathione transferase activity - Growth factor activity - Hormone activity

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>> Get this Report Now by email! - Hydrolase activity - Intracellular ligand-gated ion channel activity - Ion channel activity - Kinase activity - Kinase binding - Kinase regulator activity - Ligase activity - Lipid kinase activity - Lipid phosphatase activity - Metallopeptidase activity - MHC class I receptor activity - Molecular function unknown - Motor activity - Oxidoreductase activity - Peptidase activity - Peptide hormone - Peroxidase activity - Protease inhibitor activity - Protein binding - Protein serine/threonine kinase activity - Protein threonine/tyrosine kinase activity - Protein tyrosine phosphatase activity - Protein-tyrosine kinase activity - Receptor activity - Receptor binding - Receptor signaling complex scaffold activity - Receptor signaling protein serine/threonine kinase activity - RNA binding - RNA-directed DNA polymerase activity - Serine-type peptidase activity - Structural constituent of cytoskeleton - Structural molecule activity - Transcription factor activity - Transcription regulator activity - Transferase activity - Translation regulator activity - Transmembrane receptor activity - Transmembrane receptor protein tyrosine kinase activity - Transporter activity - Unknown - Voltage-gated ion channel activity Identified targets are categorized into 24 (21) different primary and alternate sub-cellular localizations: - Centrosome - Clathrin-coated vesicle - Cytoplasm - Cytoplasmic vesicle - Cytosol

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>> Get this Report Now by email! - Endoplasmic reticulum - Endosome - Extracellular - Extracellular matrix - Golgi apparatus - Integral to membrane - Lysosome - Microtubule - Mitochondrial membrane - Mitochondrion - n/a - Nuclear membrane - Nucleolus - Nucleus - Perinuclear region - Perinuclear vesicle - Plasma membrane - Secreted - Secretory granule Note: You are able to find and sort drugs according to target gene name, molecular function of target, and target localization from drop-down menus in the application. Target Expression Profile Direct links are provided from inside the application to 274 (221) protein expression profiles of 174 (143) drug targets in various human tissues and cancer types, cell lines and primary cells, including up to: - 48 different normal tissue types - 20 different types of cancer - 47 cell lines - 12 samples of primary blood cells Pathway Referals Identified targets have been cross referenced against their involvement in different cellular pathways, according to BioCarta, KEGG and NetPath. - BioCarta# 226 (214) Pathways - KEGG# 109 (108) Pathways - NetPath# 20 (20) Signaling Pathways Note: You are able to find and sort drugs according to targeted pathways from drop-down menus in the application. Mechanism In total there are 275 (242) different drug mechanism of action represented in this Drug Pipeline Update. Note: You are able to find and sort drugs according to mechanism of action from drop-down menu in the application. Compound Identified drug compounds are described by:

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>> Get this Report Now by email! Compound type, Chemical name, CAS Number and molecular weight Note: You are able to sort and find drugs according to compound type from drop-down menu in the application. Drug Profile Progress analysis and review of drug development. A typical drug profile reports on, depending on stage of development and available information: Drug Name & Synonyms Presentation of drug name and synonyms Principal Investigator & Partners Presentation of principal investigator and partners Target and Molecular Function of Target Described target(s) is/are presented with: Official Gene Symbol ' Official Gene Name [Species/Homo Sapiens] ' Molecular Function Target Localization Described target(s) is/are presented with primary and alternate localizations. Target Expression Profiles Links to protein expression profile(s) of target(s) in various human tissues, cell lines and primary cells, including up to: 48 different normal tissue types 20 different types of cancer 47 cell lines 12 samples of primary blood cells Targeted Pathways Described target(s) is/are matched for the involvement in cellular pathways according to BioCarta, KEGG, and NetPath. Mechanism Drug mechanism of action Developmental Projects Summary field of developmental projects for the drug, including indication, developmental stage and status. Example: Cancer, myeloma ' Phase II Clinical Trial ' Active Cancer, prostate ' Phase III Clinical Trial ' Ceased Drug Description Short introduction to drug Compound Data Compound type, Chemical name, CAS Number and molecular weight Patent Data Available patent information related to the drug is presented here.

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>> Get this Report Now by email! Business & Markets Collaborations and deals Approvals and submissions Analyst comments Phase III Data Available Phase III development data, developmental history and scientific data. Phase II Data Available Phase II development data, developmental history and scientific data. Phase I Data Available Phase I development data, developmental history and scientific data. Preclinical Data Available preclinical development data, developmental history and scientific data. Licensing Information Availability for licensing Application Features Use 13 different parameters, available in drop-down menus, to find and sort among drugs - Drug status - Clinical Trial Status - Principle Investigator - Partners - Indication - Developmental Stage - Compound Type - Mechanism - Target - Molecular Function of Target - Target Localization - Targeted Pathways - Free text search of entire drug profile contents Direct linkage from inside the application to related internet resources - Drug data is linked to search engines like Google and PubMed - Drug target data is linked directly to BioCarta, Human Protein Atlas, KEGG, and NetPath - Direct links to company web pages of principal investigators Dynamic Report Generator Our dynamic report generator lets you with ease and speed generate html reports directly in your web browser (Internet Explorer), whether it is a single drug profile or an entire search you want have a report of. System Requirements - Operating system: Windows (2000/XP/Vista/7) and Mac OS X 10.6 (Snow Leopard) and OS X 10.7 (Lion) - Browser Application (Internet Explorer)

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Colorectal Cancer Drug Pipeline Update 2011 (From Issuu)

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Colorectal Cancer Drug Pipeline Update 2011  

Until a decade ago, 5FU/leucovorin formed the mainstay of colorectal cancer treatment but Camptosar and Eloxatin quickly established themsel...