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Alpha6 Beta4 Integrin Signaling Pathway in Oncology Drug Pipeline Update 2011 Published on February 2011

Report Summary The Alpha6 Beta4 Integrin signaling pathway activates the PI 3-kinase/Akt, MAPK/NFkB and SMAD signaling modules. There are today 210 companies plus partners developing 315 Alpha6Beta4 integrin pathway targeting drugs in 938 developmental projects in cancer. In addition, there is 1 suspended drug and the accumulated number of ceased drugs over the last years amount to another 111 drugs. Alpha6 Beta4 Integrin Signaling Pathway In Oncology Drug Pipeline Update lists all drugs and gives you a progress analysis on each one of them. Identified drugs are linked to 101 different targets. These targets are further categorized on in the software application by 29 classifications of molecular function and with pathway referrals to BioCarta, KEGG and NetPath. Find and sort drugs by twelve different parameters plus free text search field. Our dynamic report generator lets you with ease and speed generate html reports directly in your web browser, whether it is a single drug profile or an entire search you want have a report of. How May Drug Pipeline Update Be of Use' * Show investors/board/management that you are right on top of drug development progress in your therapeutic area. * Find competitors, collaborations partners, M&A candidates etc. * Jump start competitive drug intelligence operations * Excellent starting point for world wide benchmarking * Compare portfolio and therapy focus with your peers * Speed up pro-active in-/out licensing strategy work * Fast and easy way of tracking drugs using search engines; just one click from inside the application and you may search the World Wide Web and PubMed for any drug. Drug Pipeline Update is delivered to you as a downloadable application, which requires no installation on your computer. Please read more about application features and system requirements below. Drug Pipeline Update at a Glance Investigators Includes more than 210 principal investigators plus their collaborators. There is direct access from inside the application to web pages of all principal investigators. Note: You are able to sort and find drugs according to investigators and partners from drop-down menus in the application. You may also sort and find drugs according to country of investigator. Drug name & Synonyms Lists commercial, generic and code names for drugs. Developmental stage This Drug Pipeline Update contains 315 Alpha6Beta4 integrin pathway targeting drugs in development, which have a total of 938 developmental projects in cancer. In addition there are suspended and ceased drugs.

Alpha6 Beta4 Integrin Signaling Pathway in Oncology Drug Pipeline Update 2011 (From Issuu)

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>> Get this Report Now by email! Pipeline Breakdown According to Number of Drugs Marketed# 19 Pre-registration# 2 Phase III# 29 Phase II# 77 Phase I# 106 Preclinical# 185 No Data# 1 Suspended# 1 Ceased# 111 Note: You are able to sort and find drugs according to developmental stage from drop-down menu in the application. Indications Included Alpha6Beta4 integrin pathway targeting drugs are also in development for 105 other indications, where of 70 are different cancer indications. Note: You are able to find and sort drugs according to type of indication from drop-down menu in the application. Targets Identified drugs are linked to more than 101 different targets, divided into 29 classifications of molecular function: - Antigen binding - Catalytic activity - Cell adhesion molecule activity - Chaperone activity - Chemokine activity - Cysteine-type peptidase activity - Cytokine activity - DNA binding - G-protein coupled receptor activity - Glutathione transferase activity - Growth factor activity - GTPase activity - Kinase activity - Kinase binding - Ligand-dependent nuclear receptor activity - Lipid kinase activity - Lipid phosphatase activity - Peroxidase activity - Protein serine/threonine kinase activity - Protein-tyrosine kinase activity - Receptor activity - Receptor signaling complex scaffold activity - Structural constituent of cytoskeleton - Structural molecule activity - Transcription factor activity - Transcription regulator activity - Translation regulator activity

Alpha6 Beta4 Integrin Signaling Pathway in Oncology Drug Pipeline Update 2011 (From Issuu)

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>> Get this Report Now by email! - Transmembrane receptor protein tyrosine kinase activity - Transporter activity Identified targets are categorized into 22 different primary and alternate sub-cellular localizations: - Cell projection - Centrosome - Chromosome - Clathrin-coated vesicle - Cytoplasm - Cytoplasmic vesicle - Cytoskeleton - Cytosol - Endoplasmic reticulum - Endosome - Extracellular - Golgi apparatus - Lysosome - Mitochondrion - Nuclear membrane - Nucleolus - Nucleus - Perinuclear region - Perinuclear vesicle - Plasma membrane - Ribosome - Secreted Note: You are able to find and sort drugs according to target gene name, molecular function of target, and target localization from drop-down menus in the application. Target Expression Profile Direct links are provided from inside the application to 149 protein expression profiles of 89 drug targets in various human tissues and cancer types, cell lines and primary cells, including up to: - 48 different normal tissue types - 20 different types of cancer - 47 cell lines - 12 samples of primary blood cells Pathway Referals Identified targets have been cross referenced against their involvement in different cellular pathways, according to BioCarta, KEGG and NetPath. - BioCarta# 199 Pathways - KEGG# 82 Pathways - NetPath# 19 Signaling Pathways Note: You are able to find and sort drugs according to targeted pathways from drop-down menus in the application. Mechanism

Alpha6 Beta4 Integrin Signaling Pathway in Oncology Drug Pipeline Update 2011 (From Issuu)

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>> Get this Report Now by email! In total there are 155 different drug mechanism of action represented in this Drug Pipeline Update. Note: You are able to find and sort drugs according to mechanism of action from drop-down menu in the application. Compound Identified drug compounds are described by: Compound type, Chemical name, CAS Number and molecular weight Note: You are able to sort and find drugs according to compound type from drop-down menu in the application. Drug Profile Progress analysis and review of drug development. A typical drug profile reports on, depending on stage of development and available information: Drug Name & Synonyms Presentation of drug name and synonyms Principal Investigator & Partners Presentation of principal investigator and partners Target and Molecular Function of Target Described target(s) is/are presented with: Official Gene Symbol ' Official Gene Name [Species/Homo Sapiens] ' Molecular Function Target Localization Described target(s) is/are presented with primary and alternate localizations. Target Expression Profiles Links to protein expression profile(s) of target(s) in various human tissues, cell lines and primary cells, including up to: 48 different normal tissue types 20 different types of cancer 47 cell lines 12 samples of primary blood cells Targeted Pathways Described target(s) is/are matched for the involvement in cellular pathways according to BioCarta, KEGG, and NetPath. Mechanism Drug mechanism of action Developmental Projects Summary field of developmental projects for the drug, including indication, developmental stage and status. Example: Cancer, myeloma ' Phase II Clinical Trial ' Active Cancer, prostate ' Phase III Clinical Trial ' Ceased Drug Description Short introduction to drug

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>> Get this Report Now by email! Compound Data Compound type, Chemical name, CAS Number and molecular weight Patent Data Available patent information related to the drug is presented here. Business & Markets Collaborations and deals Approvals and submissions Analyst comments Phase III Data Available Phase III development data, developmental history and scientific data. Phase II Data Available Phase II development data, developmental history and scientific data. Phase I Data Available Phase I development data, developmental history and scientific data. Preclinical Data Available preclinical development data, developmental history and scientific data. Licensing Information Availability for licensing Application Features Use 13 different parameters, available in drop-down menus, to find and sort among drugs - Drug status - Clinical Trial Status - Principle Investigator - Partners - Indication - Developmental Stage - Compound Type - Mechanism - Target - Molecular Function of Target - Target Localization - Targeted Pathways - Free text search of entire drug profile contents Direct linkage from inside the application to related internet resources - Drug data is linked to search engines like Google and PubMed - Drug target data is linked directly to BioCarta, Human Protein Atlas, KEGG, and NetPath - Direct links to company web pages of principal investigators Dynamic Report Generator

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>> Get this Report Now by email! Our dynamic report generator lets you with ease and speed generate html reports directly in your web browser (Internet Explorer), whether it is a single drug profile or an entire search you want have a report of. System Requirements - Operating system: Windows (2000/XP/Vista/7) and Mac OS X 10.6 (Snow Leopard) and OS X 10.7 (Lion) - Browser Application (Internet Explorer) - Internet access (to access related internet resources)

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Alpha6 Beta4 Integrin Signaling Pathway in Oncology Drug Pipeline Update 2011 (From Issuu)

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Alpha6 Beta4 Integrin Signaling Pathway in Oncology Drug Pipeline Update 2011  

The Alpha6 Beta4 Integrin signaling pathway activates the PI 3-kinase/Akt, MAPK/NFkB and SMAD signaling modules.There are today 210 companie...

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