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P ORT FO L I O RE V I E W:

Genesis Genetics


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Mark Hughes, MD, PhD CEO mark.hughes@genesisgenetics.org 705 S. Main St., Plymouth, MI, USA 48170 313.579.9650 313.544.4006 genesisgenetics.org

Horizontal version Tasos Kotzadamis, MSc Senior Laboratory Scientist Genesis Genetics London tasos.kotzadamis@genesisgenetics.org The London Bioscience Innovation Centre 2 Royal College Street, London NW1 0NH +44 (0) 20 7691 1122, ext. 226 genesisgenetics.co.uk

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Where Quality Meets Gene1cs Helping Build Healthy Families All Over the Globe

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Where Quality Meets Gene1cs

Where Quality Meets Gene1cs

An Introduc1on

An Introduc1on

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Brochures and Folders Genesis Genetics will work with you every step of the way. Our team of coordinators,

PGD and PGS Patient Brochures

genetic counselors, physicians and scientists have strong relationships with your IVF center. When your doctor enrolls you in the PGS program with Genesis Genetics, you can expect a prompt email from a dedicated case coordinator who will introduce you to The Genesis Commitment.

Improving IVF Success

313.579.9650 | info@genesisgenetics.org | genesisgenetics.org

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WHAT IS PGS? Preimplantation Genetic Screening (PGS) is a genetic test that increases your chance of getting pregnant and having a healthy baby. PGS examines DNA from embryos to determine whether the correct amount of genetic material is present. This test identifies embryos with extra or missing copies of chromosomes. Selecting healthy embryos with the correct number of chromosomes:

WHO CAN BENEFIT FROM PGS?

• Increases the chance of a healthy pregnancy across all age groups • Reduces the likelihood of miscarriage • Allows for confident single embryo transfer, which avoids the added health complications of twin or triplet pregnancies

Yang et al. (2012). Molecular Cytogenetics 5:24

• Provides the ability to determine gender of the embryo before transfer in the womb, if permitted in your country and ordered by your doctor

PGS screening is appropriate for a vast majority of IVF patients. Many embryos produced in an IVF cycle will have an incorrect number of chromosomes. As a woman’s age increases, so does her risk of producing an abnormal embryo. A woman over 35 years of age can expect around half of her embryos will have either too many or too few chromosomes. Younger couples also produce a significant number of embryos with abnormal chromosomes. Embryos with extra or missing chromosomes usually result in miscarriage, but can also result in children with health problems, such as Down syndrome.

HOW IS PGS PERFORMED? PGS testing is performed on a small number of cells carefully extracted from a developing embryo. This procedure is called a biopsy and is performed by an embryologist at the IVF clinic. The cells collected in the biopsy are then sent to Genesis Genetics where they are scanned for thousands of DNA sequences that are unique to each chromosome. Analyzing these DNA sequences allows us to count the number of chromosomes in the cells. The results from the PGS test are then sent back to the IVF clinic so that a healthy embryo can be selected for transfer.

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PGD SHOULD BE CONSIDERED IF: • You have a child who has been diagnosed with an inherited genetic disorder

PHYSICIAN REFERRAL

• You have personally been diagnosed with a hereditary condition • A member of your family has been diagnosed with a hereditary disorder • You and/or your partner have been identified as carriers of a genetic disease

PHONE CONSULTATION WITH GENESIS GENETICS

HOW IS PGD PERFORMED?

WHAT IS PGD? Preimplantation Genetic Diagnosis (PGD) is a test performed on embryos to avoid a specific genetic condition affecting your family. PGD has the ability to diagnose known hereditary disorders in embryos prior to pregnancy, to help assure your family that a healthy child is on the way. Genesis Genetics’ founder Dr. Mark Hughes developed PGD 25 years ago, and continues to advance this technology today.

PGD involves the creation of a customized genetic test for your embryos, based on your family’s unique genetic make-up, using our laboratory’s state-of-the-art molecular technology. This personalized genetic test allows us to determine the disease status of your embryos prior to transfer of that embryo into the womb.

NEXT STEPS Genesis Genetics will work closely with you and your IVF clinic to coordinate the PGD testing process.

PERSONALIZED DNA TEST IS DEVELOPED

EMBRYO SAMPLE TESTING

CHROMOSOME TESTING (PGS) Having the correct number of chromosomes is also important for an embryo to result in a healthy pregnancy. Genesis Genetics can easily screen the chromosomes of your embryo at the same time your PGD test is being performed. Please discuss this option with your physician if you feel that PGS testing might be right for you.

REPORT SENT TO YOUR DOCTOR

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PGD and PGS Patient Brochures featuring Billing Options Panel and Insert

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Brochures and Folders

Provider’s Manual

Data Book


Patient and Clinic Pocket Folders

Biopsy and Logistics Brochure

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Tabletop Display

NSGC Booth

PCRS Tabletop Display

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Advertising and Promotions AAB Program Ad

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Genesis Genetics Canada Handout


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Web and Social Media Website


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Packaging Genesis Reassure Box Sleeve

Genesis Biopsy Kit Packaging


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9349 N Haggerty Rd | Plymouth, MI 49170 | 734 927 7168 | rbdcreative.com


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