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META ANALYSIS & SYSTEMATIC REVIEW

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META ANALYSIS Publication Support | Research Services | Physician Writing | Scientific Communication Solution | Editing &Peer-Reviewing

Copyright © 2019 pubrica. All rights reserved


Writing Meta Analysis

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Pubrica has extensive experience in conducting meta-analysis a quantitative, formal, epidemiological study design used to systematically assess the results of previous research to derive conclusions about that body of research.

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As a general principle, generating, summarizing, and understanding the best available evidence are essential for establishing the benefits and safety of interventions. A well designed and implemented meta-analysis study can be a great benefit to society. While meta-analysis has the potential to be a powerful tool in evaluating health care treatments and interventions, there are many potential pitfalls and problems that are yet to be resolved.

Introduction

A poorly performed meta-analysis can perpetuate biases from illconceived studies or lead to false conclusions. Contd..

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This, in turn, can cause consumers and caregivers, who frequently access results of meta-analysis through websites and popular press, to form incorrect conclusions and can result in inappropriate medical decisions. While the idea behind combining studies to improve precision and power is straightforward, the actual implementation of the process is difficult. Those who act or react based on meta-analysis should understand the various biases that could be incorporated into a review. Examples of some potential pitfalls in meta-analysis include publication bias, pipeline bias, and English language bias. In addition, combining studies that are not similar in study design, population, methods of analysis or outcome definitions can lead to biases as well,which may result in spurious conclusions being drawn.

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Services Guidelines for Reporting: Moreover, a useful guide to improve reporting of systematic reviews and metaanalysis is the PRISMA (Preferred Reporting Items for Systematic reviews and Metaanalysis) statement that replaced the QUOROM (Quality of Reporting of Metaanalysis) statemen. Detailed Literature Search: We include all relevant studies, because loss of studies can lead to bias in the study. Typically, published papers and abstracts are identified by a computerized literature search of electronic databases that can include PubMed (www.ncbi.nlm.nih.gov./entrez/query.fcgi), ScienceDirect (www.sciencedirect.com), Scirus (www.scirus.com/srsapp ), ISI Web of Knowledge (https://www.isiwebofknowledge.com), Google Scholar (https://scholar.google.com) and CENTRAL (Cochrane Central Register of Controlled Trials, https://www.mrw.interscience.wiley.com/cochrane/ochrane_clcentral_articles_fs.htm). Publication Support | Research Services | Physician Writing | Scientific Communication Solution | Editing &Peer-Reviewing

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Heterogeneity

Statistical Analysis

Heterogeneity is inherent in metaanalysis, not a problem to be solved. It includes clinical components (eg, diversity in patient populations or interventions) and statistical components (eg, random differences).

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SYSTEMATIC REVIEW Publication Support | Research Services | Physician Writing | Scientific Communication Solution | Editing &Peer-Reviewing

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Performing a rigorous systematic review is multi-step process, which includes Identifying a well-defined focused clinically relevant question,

Systematic Review

Developing a detailed review protocol with strict inclusion and exclusion criteria, Systematic literature search of multiple databases and unpublished data, in consultation with a medical librarian, Meticulous study identification and Systematic data abstraction, by at least two sets of investigators independently, Risk of bias assessment, and Thoughtful quantitative synthesis through meta-analysis where relevant.

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General Structure

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Formulate the research question Search for studies Selection of studies Data collection Methodology quality assessment Results are analysed and presented Findings are interpreted.

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The Role of Systematic review and Meta-Analysis in Scientific research- Pubrica.com  

Pubrica has extensive experience in conducting meta-analysis a quantitative, formal, epidemiological study design used to systematically ass...

The Role of Systematic review and Meta-Analysis in Scientific research- Pubrica.com  

Pubrica has extensive experience in conducting meta-analysis a quantitative, formal, epidemiological study design used to systematically ass...

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