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International September 29 - October 3, 2013 Toronto, Ontario, Canada

Preliminary Program & Registration Brochure


International

September 29 - October 3, 2013 Toronto, Ontario, Canada

INVITATION TO ATTEND Dear Colleagues, On behalf of the Meeting Organizing Committee, it is my great pleasure to invite you to the premier international meeting on xenobiotics: the 10th International ISSX Meeting, to convene September 29 – October 3, 2013 in Toronto, Ontario, Canada. This meeting provides a wonderful opportunity for members of the international scientific community to exchange ideas and expertise, to develop a common vision, and to create and nurture fruitful collaborations in fields related to the study of chemicals that are foreign to the body. Enjoy state-of-the-art scientific sessions, poster presentations, and commercial exhibits in a relaxed and friendly environment. Proposed topics for a combination of a keynote lecture, plenary sessions, parallel sessions and short course workshops in Toronto include: systems pharmacology and xenobiotic-host interactions; drug-metabolizing enzymes as potential therapeutic targets; metabolism and pharmacokinetics of traditional medicines; regulatory challenges in drug development and approval; toxicogenomic profiling; in vitro and cell-based systems for predicting human drug metabolism; cell type specific mechanisms of toxicity and adverse drug reactions; nuclear receptors as regulators of drug metabolism and therapeutic targets; novel biomarkers for xenobiotic-induced toxicity; utility of structural biology in predicting drug response, metabolism and ADRs; and many more. Please take this unique opportunity to expand and share your knowledge on the interaction of foreign chemicals with living systems, renew or develop friendships with your colleagues from around the world, and enjoy everything the wonderful city of Toronto has to offer. I look forward to seeing you in Toronto! Sincerely,

Denis M. Grant University of Toronto Chair, Meeting Organizing Committee

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Why You Should Attend the 10th International ISSX Meeting This meeting will bring together individuals who are actively working on drug/xenobiotic research in diverse fields including basic and clinical pharmacology and therapeutics, toxicology, oncology, endocrinology, physiology, biochemistry, medicinal chemistry, molecular and structural biology, and genetics. If you work in the fields of toxicology, pharmacy, or molecular biology or if you study xenobiotics, you can’t afford to miss the 10th International ISSX Meeting. • S  cientific meetings organized by ISSX offer numerous outstanding scientific sessions and many opportunities for substantive conversations with scientists worldwide. Our exhibitors will be showcasing the products and services important to you in your research and development. • E xpand your knowledge of drug metabolism and disposition by learning from our outstanding faculty assembled from leading experts in the field worldwide.

• G  ain recognition and feedback on your research by submitting an abstract and presenting a poster. All accepted abstracts will be printed in a special supplemental issue of Drug Metabolism Reviews. Students and postdocs may enter the poster competition and compete for prizes and recognition. • Learn the latest information in this dynamic and specialized field through our Short Course program—a variety of timely scientific symposia, and topical keynote and plenary sessions. • E njoy informal social interactions with fellow researchers, and also enjoy exploring Toronto - Canada’s largest city, its financial center, and the capital of the province of Ontario. In Toronto you will find a vibrant, safe and walkable downtown core, excellent transit access to many cozy neighborhoods, stunning traditional and modern architecture, world-class museums and galleries, an abundance of nightlife, and more than 7,000 restaurants of every price range and ethnic flavor imaginable!

What is ISSX? The International Society for the Study of Xenobiotics (ISSX) is an international association of scientists that promotes the understanding of the interactions of medicines and chemicals with living systems. We organize cutting-edge scientific meetings and provide opportunities to bring together researchers in industry, academia, and government who are interested in the metabolism, disposition, and effects of xenobiotics—chemicals that are foreign to the body.

TABLE OF CONTENTS Meeting Organizing Committee................... 4 International Scientific Advisory Board.......... 4 Registration Information.............................. 5 Abstract Submissions.................................. 6 Poster Information...................................... 7 Program At A Glance................................. 8 Short Course Program................................ 10 Meeting Program....................................... 12 General Information................................... 18 SPECIAL EVENT ISSX Party at the Hockey Hall of Fame.......... 18 Sixth International Workshop on the Arylamin N-Acetyltransferases................ 21

www.issx.org


International

September 29 - October 3, 2013 Toronto, Ontario, Canada

MEETING ORGANIZING COMMITTEE (MOC) Denis Grant (Meeting Chair) University of Toronto, Toronto, ON, Canada

Eddie Morgan Emory University Atlanta, GA, USA

Stelvio Bandiera University of British Columbia, Vancouver, BC, Canada

Sandy Pang University of Toronto, Toronto, ON, Canada

Jack Bend University of Western Ontario, London, ON, Canada

Allan Rettie University of Washington, Seattle, WA, USA

Chantal Guillemette Laval University, Quebec, QC, Canada

David Riddick University of Toronto, Toronto, ON, Canada

Malle Jurima-Romet Celerion, Montreal, QC, Canada

Nathalie Rioux Boehringer Ingelheim (Canada), Ltd., Laval, QC, Canada

David K.H. Lee InterVivo Solutions, Inc., Mississauga, ON, Canada

Rachel Tyndale University of Toronto, Toronto, ON, Canada

Tom Massey Queen’s University, Kingston, ON, Canada

Peter Wells University of Toronto, Toronto, ON, Canada

INTERNATIONAL SCIENTIFIC ADVISORY BOARD (ISAB) Ann Daly Newcastle University, Newcastle upon Tyne, UK

B. Kevin Park University of Liverpool, Liverpool, United Kingdom

Patrick Dansette Université Paris Descartes, Sorbonne Paris Cité, Paris, France

Olavi Pelkonen University of Oulu, Oulu, Finland

Xinxin Ding Wadsworth Center, Albany, NY, USA

Rory Remmel University of Minnesota, Minneapolis, MN, USA

Uwe Fuhr University Hospital of Cologne, Cologne, Germany

A. David Rodrigues Bristol-Myers Squibb, Princeton, NJ, USA

Ron Hines Medical College of Wisconsin, Milwaukee, WI, USA

Glenn Sipes University of Arizona College of Medicine, Tucson, AZ, USA

Paul Hollenberg University of Michigan Medical School, Ann Arbor, MI, USA

Bill Smith (ISSX President) Pfizer Inc. La Jolla Labs, San Diego, CA, USA

Richard Kim University of Western Ontario, London, ON, Canada

Steven Tannenbaum MIT, Cambridge, MA, USA

Steve Leeder Children’s Mercy Hospital, Kansas City, MO, USA

Ken Thummel University of Washington, WA, USA

Chuan Li Shanghai Institute of Materia Medica, Shanghai, China

Jacques Turgeon Centre Hospitalier de L’Universite de Montreal, Montreal, QC, Canada

Peter Mackenzie Flinders University School of Medicine, Adelaide, Australia

Donald Tweedie Boehringer Ingelheim, Ridgefield, CT, USA

Larry Marnett Vanderbilt University School of Medicine, Nashville, TN, USA

Jack Uetrecht University of Toronto, Toronto, ON, Canada

Urs Meyer (Past ISSX President) Biozentrum, University of Basel, Basel, Switzerland

Yasushi Yamazoe Tohoku University, Sendai, Japan

Deborah Nicoll-Griffith Merck & Co., Rahway, NJ, USA

Uli Zanger Dr. Margarete Fischer-Bosch Institute, Stuttgart, Germany

Franz Oesch University of Mainz Institute of Toxicology, Mainz, Germany 4


REGISTRATION INFORMATION

International

MEETING REGISTRATION FEE INCLUDES ADMITTANCE TO: • • • • • • •

Scientific sessions Awards presentation and lectures Poster presentations Competition and awards for best poster presentations by predoctoral and postdoctoral researchers Exhibit Hall Welcome reception Access to all accepted meeting abstracts in an online supplement of Drug Metabolism Reviews

Registration is now open! Click to Register

Visit www.issx.org/international2013/registration. Register by June 28 to take advantage of the early registration discount incentive! SHORT COURSE REGISTRATION Short Courses will be held on Sunday, September 29 (All fees in USD.)

EARLY

REGULAR

ON-SITE

Short Course Attendee Category

(January 31-June 28)

(June 29-September 27)

(September 29-October 4)

ISSX Member

$175

$225

$250

Student/Postdoc Member

$100

$125

$150

Non-Member

$225

$275

$325

MEETING REGISTRATION

EARLY

REGULAR

ON-SITE

Meeting Attendee Category

(January 31-June 28)

(June 29-September 27)

(September 29-October 4)

ISSX Member

$595

$695

$795

Student/Postdoc Member

$225

$250

$275

Non-Member

$745

$825

$945

Guest*

$50

$50

$50

ISSX Party at Hockey Hall of Fame

$100

$100

$100 (If tickets are available)

*Guest registration allows guest admittance to the Opening Welcome Reception on Sunday, September 29 and to refreshment breaks throughout the 10th International Meeting. Guest registrants are not permitted into the session rooms. Cancellations must be received by email or in writing and postmarked no later than Friday, August 30, 2013. No refunds can be made for cancellations received after August 30. Please fax cancellation requests to the attention of ISSX Meeting Registration at (202) 367-2160 and maintain a copy of your successful fax transmission report. ISSX will refund registration fees paid, less a $50 administrative fee, for each cancellation received by this date. Substitutions may be made at any time, but must be submitted in writing. ISSX Membership Before registering for the meeting, join ISSX or renew your ISSX Membership to be eligible for steep registration discounts and other valuable benefits! Membership in ISSX grants reduced meeting registration fees and the opportunity to submit an abstract for poster presentation at the 10th International ISSX Meeting. Visit www.issx.org/membership for details.

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International

September 29 - October 3, 2013 Toronto, Ontario, Canada

ABSTRACT SUBMISSION We encourage all those involved in the fields of metabolism, pharmacology, toxicology, molecular biology, and other related disciplines to consider submitting an abstract for a poster presentation at the 10th International ISSX Meeting. Visit www.issx.org/international2013/abstracts. Present a poster in the General Abstract Poster Sessions. General abstract sessions will be held Monday, September 30 - Wednesday, October 2 in the Exhibit Hall. Compete in the Student Poster Awards Competition. Open to the categories of student (predoctoral) and graduate (postdoctoral) students, six finalists from each category will be chosen to present their posters. The awards presentation will be held on Thursday, October 3. This meeting also features two abstract-based sessions. Abstracts will be selected by the meeting organizers from the General Abstract Poster Presentation submissions. At least one abstract author must be a current ISSX member. The deadline for General Abstract Poster Presentations submissions and for student (predoctoral) and graduate (postdoctoral) Poster Awards Competition submissions is Friday, May 31, 2013 at 11:59 p.m., Eastern Time (US). All accepted abstracts for this meeting will be included in the meeting proceedings publication, published in a supplement to Drug Metabolism Reviews, and will be cataloged on the searchable online abstract database.

POSTER PRESENTATION 1. Posters are normally presented by the first author. 2. Posters are to be mounted on the assigned board only. Boards will be numbered to correspond to abstract numbers. 3. Poster can be affixed to the boards with push pins. Please bring your own push pins. (A very limited supply will be available at the registration desk.) 4. Do not write on, or otherwise mark, the surface of the poster board. 5. Please refer to schedule below for times to mount and dismantle posters and for times authors should be present with their posters.

POSTER SCHEDULE Date and Session

SET-UP TIME

POSTER VIEWING

AUTHORS PRESENT

DISMANTLE TIME

Monday, September 30 Session 1

07:30 – 08:30

08:30 – 18:00

12:00 – 13:00

18:00 – 19:00

Tuesday, October 1 Session 2

07:30 – 08:30

08:30 – 18:00

13:00 – 14:00

18:00 – 19:00

Wednesday, October 2 Session 3

07:30 – 08:30

08:30 – 18:00

13:00 – 14:00

18:00 – 19:00

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ABSTRACT POSTER BOARD DIMENSIONS AND POSTER PRESENTATION

VERTICAL LENGTH 4 feet (121.92 cm/48 in.)

HORIZONTAL LENGTH 4 feet (121.92 cm/48 in.)

Poster Boards are divided so that two posters will fit each side of the board. POSTER DIMENSIONS

To ensure that your poster will not interfere with your neighbors’ posters, do not exceed the prescribed horizontal length of 4 feet (121.92 cm/48 in).

POSTER BOARD DIMENSIONS: Please be advised that your poster dimensions should be formatted to fit within the poster board space of 4 feet (121.92 cm/48 in) in width and 4 feet (121.92 cm/48 in) in height. Formatting your poster to fit these dimensions will ensure that adequate space will be provided for your poster and those of other attendees. A diagram of these dimensions appears above for your reference. The posters may be secured to the boards by push-pins. Please bring push-pins to fasten your poster to the board as a limited supply will be available at the meeting.

POSTER TEXT AND LAYOUT: 1. Posters must fit within the dimensions of the board. ISSX recommends creating a poster which is a maximum of 46 inches wide x 46 inches in length to maximize the amount of space available for your poster. 2. All material should large enough to be read from a distance of six feet (two meters). 3. The poster should be self-explanatory. 4. The poster should contain the title, authors’ name(s), and affiliation(s), the abstract, objectives, results, and conclusions. 5. Use clear tables and figures. Structural information MUST be included in the poster. 6. Judicious use of color can often add emphasis.

POSTER MATERIALS AND TUBES: ISSX is not responsible for damage to or removal of posters if they are left in the exhibit hall after the allotted poster removal time. ISSX is not responsible for loss or damage to poster tubes or personal items. Do not leave poster tubes and personal items unattended beneath your poster.

Submit an Abstract

Visit www.issx.org/international2013/abstracts. Submit an abstract by May 31 to share your work with colleagues from around the world.

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Click to Submit


International

PROGRAM AT

SUNDAY

Promega Corporation Industry-Supported Symposium

Morning Course Attendee Continental Breakfast SHORT COURSE II

Metabolomic Profiling as a Tool for Identifying Novel Drug-Target Reactions

Model Systems and Methods for Assessing Uptake and Efflux of Small Molecules

Afternoon Course Attendee Lunch SHORT COURSE III

SHORT COURSE IV

Strategies and Techniques for Predicting Human Drug Metabolism and Drug-Drug Interactions

Application of Novel Mass Spectrometric Methods to Drug Metabolism and Pharmacokinetics Studies

TU Thermo Scientific Industry-Supported Symposium

Bruker Dalto Industry-Supp Symposium

PLENARY SESSION 1 Drug-Metabolizing Enzymes as Potential Therapeutic Targets

Utility of Genetic Developmen

Refreshment Break, Visit Exhibitors, View Posters

Refreshment Br

ISSX AWARDS SESSION

PARALLEL SES

R.T. Williams Distinguished Scientific Achievement Award and the Frederick J. Di Carlo Distinguished Service Award

Lunch (on own), Visit Exhibitors, View Posters PARALLEL SESSION 1 PARALLEL SESSION 2 Nuclear Receptors as Regulators of Drug Metabolism and as Therapeutic Targets

Pharmacogenomics and Personalized Medicine: Progress in Clinical Implementation

Refreshment Break, Visit Exhibitors, View Posters

PARALLEL SESSION 3 PARALLEL SESSION 4 Regulation of Drug Transporter Expression and Function

Opening Welcome Address KEYNOTE LECTURE: Systems Pharmacology and Drug-Host Interactions

Application of Structural Biology to the Prediction of Drug Response, Metabolism and Toxicity

YOUNG INVESTIGATORS RECEPTION

OPENING WELCOME RECEPTION WITH EXHIBITORS

8

PLE

REGISTRATION OPEN

SHORT COURSE I

REGISTRATION OPEN

REGISTRATION OPEN

7:30 7:45 8:00 8:15 8:30 8:45 9:00 9:15 9:30 9:45 10:00 10:15 10:30 10:45 11:00 11:15 11:30 11:45 12:00 12:15 12:30 12:45 13:00 13:15 13:30 13:45 14:00 14:15 14:30 14:45 15:00 15:15 15:30 15:45 16:00 16:15 16:30 16:45 17:00 17:15 17:30 17:45 18:00 18:15 18:30 18:45 19:00 19:15 19:30 19:45 20:00 20:15 20:30 20:45 21:00 21:15 21:30 21:45 22:00

MONDAY

Metabolism, Pharma and Interactio Traditional Medic Natural Prod

Lunch (o

FREE AF


A GLANCE

onics ported m

WEDNESDAY

Corning Incorporated Industry-Supported Symposium

Industry-Supported Symposium

ENARY SESSION 2

THURSDAY

Industry-Supported Symposium

PLENARY SESSION 3 Identification and Use of Novel Biomarkers for Xenobiotic-Induced Toxicity

reak, Visit Exhibitors, View Posters

Refreshment Break, Visit Exhibitors, View Posters

SSION 5 PARALLEL SESSION 6

PARALLEL SESSION 7 PARALLEL SESSION 8

macokinetics ons of cines and ducts

Cell Type Specific Mechanisms of Adverse Drug Reactions

on own), Visit Exhibitors, View Posters

FTERNOON IN TORONTO

REGISTRATION OPEN

c and Epigenetic Technologies in Drug nt and Safety Assessment Targets

Targeted Drug Delivery for Enhanced Therapy

Use of PB-PK Modeling in Pharmaceutical Safety Assessment

REGISTRATION OPEN

UESDAY

September 29 - October 3, 2013 Toronto, Ontario, Canada

PLENARY SESSION 4 Genetically Modified Animal Models for Predicting Human Drug Disposition and Response Poster Awards Presentation Refreshment Break

PARALLEL SESSION 11 PARALLEL SESSION 12 Tissue Imaging and Distribution Studies in Drug Development

Development and Uses of Hepatocyte-Derived and Hepatocyte-Like Cells for Predicting Human Drug Metabolism

Meeting Closing Remarks

Lunch (on own), Visit Exhibitors, View Posters PARALLEL SESSION 9

PARALLEL SESSION 10

Regulatory Perspectives Toxicogenomic and Metabolomic in Drug-Drug Interactions Profiling: Current Status and and Metabolites in Future Utility in Assessing Drug Safety Testing Efficacy and Safety Assessment Refreshment Break, Visit Exhibitors, View Posters

ISSX PARTY AT THE HOCKEY HALL OF FAME TICKETED EVENT Program subject to change. 9


SCIENTIFIC PROGRAM

International

(subject to change)

SHORT COURSE PROGRAM Join your colleagues for one or two of the valuable short courses scheduled for the day preceding the International Meeting on Sunday, September 29, 2013. Register for a morning and/or an afternoon course. The short course registration fee includes entrance to the course, a set of course materials (provided digitally), and a continental breakfast for morning course attendees or a light lunch for afternoon course attendees.

08:00 - 19:00

10:40 – 11:20

Registration Open

Metabolomic Profiling as a Tool for Identifying Novel Drug-Target Reactions

08:00 – 09:00

Theodore Sana, Agilent Technologies, Life Sciences Group, Santa Clara, California, USA

Morning Course Attendee Continental Breakfast

11:20 – 12:00

09:00 – 12:00

Metabolomics and Xenobiotics

CONCURRENT MORNING COURSES

David Wishart, University of Alberta, Department of Biological Sciences, Alberta, Canada

SHORT COURSE I

SHORT COURSE II

Metabolomic Profiling as a Tool for Identifying Novel Drug-Target Reactions

Model Systems and Methods for Assessing Uptake and Efflux of Small Molecules

Chair: David Wishart, University of Alberta, Department of Biological Sciences, Alberta, Canada

Chair: Reina Bendayan, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada The objectives of this short course are: 1) to provide cutting-edge information on in vitro and in vivo methodologies as well as model systems used for the assessment of the permeability of small therapeutic molecules in key organs such as the liver, intestine, kidney, brain as well as skeletal muscle and 2) to discuss the integration of the various experimental methods into translational Pharmacokinetic (PK) and Pharmacodynamic (PD) models.

09:00 – 09:40 Metabolic Phenotyping Technologies and Their Expanding Applications in Medicine John Lindon, Imperial College London, Department of Biological Chemistry, London, UK 09:40 – 10:20 Stable Isotope Resolved Metabolomics in Cells, Tissue and Animal Models: A Tool for Evaluating Response to Cancer Therapeutic Agents

09:00 – 09:30 Development of Novel Tools for Drug Transport Assessment

Andrew Lane, University of Louisville, James Graham Brown Cancer Center, Louisville, Kentucky, USA

Matt Soars, Bristol Myers Squibb, Metabolism and Pharmacokinetics, Wallingford, Connecticut, USA

10:20 – 10:40 Refreshment Break

09:30 – 10:00 In vitro and in vivo Estimation of Hepatic Drug Clearance-Involvement of Active Uptake Peter Webborn, AstraZeneca R&D Charnwood, Discovery DMPK, Loughborough, UK

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10:00 – 10:30

14:50 – 15:10

In vitro and in vivo Assessment of Drug Transport into Skeletal Muscle

Refreshment Break

Rommel Tirona, London Health Sciences Centre -University Hospital, Department of Medicine, London, Ontario, Canada

15:10 – 15:50 Top-Down Modeling of the Dynamic Inhibition of Liver and Gut Wall CYP3A by Voriconazole

10:30 – 10:50 Refreshment Break

Sebastian Frechen, University of Cologne, Department of Pharmacology, Cologne, Germany

10:50 – 11:25

15:50 – 16:30

Incorporating in vitro Information into Models which Integrate Intestinal and Renal Drug Transport

Predicting Complex Drug-drug Interactions for Multiple Inhibitor Systems and Multiple Inhibited Pathways

Amin Rostami-Hodjegan, University of Manchester, School of Pharmacy, Manchester, UK

Nina Isoherranen, University of Washington, School of Pharmacy, Department of Pharmaceutics, Seattle, Washington, USA

11:25 – 12:00

SHORT COURSE IV:

Drug Transport in the Brain: Models of Blood-Brain Barrier and Brain Parenchyma

Application of Novel Mass Spectrometric Methods to Drug Metabolism and Pharmacokinetics Studies

Reina Bendayan, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada

Chair: Ragu Ramanathan, QPS, Newark, Delaware, USA The objectives of this course are: 1) to provide information about the current and novel liquid chromatography-mass spectrometry (LC-MS) based techniques available to generate drug metabolism and pharmacokinetics information as part of small molecule/peptide drug discovery and development and 2) to provide examples of applications of novel mass spectrometry techniques for quantitation of drugs/metabolites in discovery, non-regulated and regulated studies as well as methods for metabolite structural elucidation and reactive metabolite screening.

12:00 – 13:30 Afternoon Course Attendee Lunch 13:30 – 16:30

CONCURRENT AFTERNOON COURSES SHORT COURSE III: Strategies and Techniques for Predicting Human Drug Metabolism and Drug-Drug Interactions

13:30 – 14:10

Co-Chairs: Uwe Fuhr, University Hospital of Cologne, Institute of Pharmacology, Cologne, Germany

Mass Spectrometry in a Drug Discovery Setting: Utility and Issues

Olavi Pelkonen, University of Oulu, Pharmacology & Toxicology, Oulu, Finland

Walter Korfmacher, Genzyme/Sanofi, Waltham, Massachusetts, USA

The objectives of this short course are: 1) to survey current and emerging in vitro tools to detect and measure interactions between xenobiotics and macromolecules metabolizing and transporting them, also in the case of multiple xenobiotics and pathways. 2) to describe modeling and simulation approaches to predict the in vivo consequences of in vitro measurable interactions in the context of the multiple pathways and the whole organism.

14:10 – 14:50 Integrating Drug Metabolism and Pharmacokinetics Studies Using High Resolution Mass Spectrometry Ragu Ramanathan, QPS, Newark, Delaware, USA 14:50 – 15:10

13:30 – 14:10

Refreshment Break

Predicting Drug Metabolism and Transporter Drug Interactions in Drug Discovery: Challenges and Novel Techniques

15:10 – 15:50 Novel LC-MS Techniques for Reactive Metabolite Screening

Tommy B. Andersson, AstraZeneca, R&D, Mölndal, Sweden

Raju Subramanian, Amgen, Thousand Oaks, California, USA

14:10 – 14:50 PBPK Coupled Systems Biology Modeling for Mechanistic Predictions of Pathway Interactions

15:50 – 16:30 LC-MS Applications in Regulated Bioanalysis

Frederic Bois, Université de Technologie de Compiègne, Compiègne, France

Steve E. Unger, Worldwide Clinical Trials, Bioanalytical Sciences, Austin, Texas, USA 11


MEETING PROGRAM SUNDAY, SEPTEMBER 29, 2013 18:00 – 21:00

10:30 – 11:00

18:00 – 18:15

11:00 – 12:00

Opening Welcome Remarks

ISSX AWARDS SESSION

Denis Grant, 10th International ISSX Meeting Chair and Bill Smith, ISSX President

Presentation of the R.T. Williams Distinguished Scientific Achievement Award

18:15 – 19:00

Presentation of the Frederick J. Di Carlo Distinguished Service Award

Refreshment Break, Visit Exhibitors, View Posters

Nominations accepted until June 30, 2013: www.issx.org/awards/nominations

KEYNOTE LECTURE: Systems Pharmacology and Drug-Host Interactions Douglas Lauffenburger, Massachusetts Institute of Technology, Department of Biological Engineering, Cambridge, Massachusetts, USA

12:00 – 13:30 Lunch (on own), Visit Exhibitors, View Posters

19:00 – 21:00 Opening Welcome Reception with Exhibitors

13:30 – 15:30

MONDAY, SEPTEMBER 30, 2013 07:30 – 18:00

PARALLEL SESSION 1

PARALLEL SESSIONS 1 AND 2

Nuclear Receptors as Regulators of Drug Metabolism and as Therapeutic Targets

07:30 – 18:00 Registration Open

Co-Chairs: Ulrich Zanger, Dr Margarete Fischer Bosch Institute of Clinical Pharmacology, Stuttgart, Germany

07:45 – 08:45

Hongbing Wang, University of Maryland, School of Pharmacy, Department of Pharmaceutical Science, Baltimore, Maryland, USA

Industry-Sponsored Symposia 13:30 – 14:00

09:00 – 10:30

PLENARY SESSION 1:

ADP-ribosylation by ARTD14 Differentially Modulates Nuclear Receptor Function

Drug-Metabolizing Enzymes as Potential Therapeutic Targets

Jason Matthews, University of Toronto, Department of Pharmacology and Toxicology, Toronto, Ontario, Canada

Chair: Paul Hollenberg, University of Michigan, Department of Pharmacy, Ann Arbor, Michigan, USA

14:00 – 14:30

09:00 – 09:30

The Nuclear Receptor CAR as a Novel Therapeutic Target in Hematological Malignancies

Human Cytochrome P450s as Therapeutic Targets for Mechanism-based Inactivators

Hongbing Wang, University of Maryland, School of Pharmacy, Department of Pharmaceutical Science, Baltimore, Maryland, USA

Paul Hollenberg, University of Michigan, Department of Pharmacy, Ann Arbor, Michigan, USA

14:30 – 15:00

09:30 – 10:00

Nuclear Receptors PXR and CAR in the Crossroads of Drug Metabolism and Energy Metabolism Wen Xie, University of Pittsburgh, Department Of Pharmaceutical Sciences, Pittsburgh, Pennsylvania, USA

Targeting the Arylamine N-acetyltransferases in Cancer Rod Minchin, University of Queensland, School of Biomedical Sciences, Queensland, Australia

15:00 – 15:30 Regulation of Drug Metabolism and Endogenous Functions by PPARα versus CAR/PXR

10:00 – 10:30 Inhibition of Cytochrome P450 17A1: Targeting Androgen Production in Prostate Cancer

Ulrich Zanger, Dr Margarete Fischer Bosch Institute of Clinical Pharmacology, Stuttgart, Germany

Emily Scott, University of Kansas, Lawrence, Kansas, USA 12


PARALLEL SESSION 2

16:30 – 17:00

Pharmacogenomics and Personalized Medicine: Progress in Clinical Implementation

Regulation of Drug Transporters in Liver by Activation of Nuclear Receptors

Chair: Rachel Tyndale, University of Toronto, Toronto, Ontario, Canada

Curtis Klaassen, University of Kansas Medical Center, Kansas City, Kansas, USA

13:30 – 14:00

17:00 – 17:30

Pharmacogenomics of Adverse Drug Reactions

Regulation of ABC Transporters at the Blood-Brain and Blood-Spinal Cord Barriers

Munir Pirmohamed, The Wolfson Centre for Personalised Medicine, Institute of Translational Medicine, University of Liverpool, Liverpool, UK 14:00 – 14:30 Clinical Implementation of Pharmacogenetics in Children: From Guidelines to Clinical Decision Support

David Miller, NIH/NIEHS Lab of Pharmacology & Chemistry, Durham, North Carolina, USA 17:30 – 18:00 Regulation of Drug Transporters in Disease Micheline Piquette-Miller, University of Toronto, Toronto, Ontario, Canada

James M. Hoffman, St. Jude Children’s Research Hospital, Memphis, Tennessee, USA 14:30 – 15:00

PARALLEL SESSION 4:

Warfarin Pharmacogenetics - Evidence and Clinical Implementation

Application of Structural Biology to the Prediction of Drug Response, Metabolism and Toxicity

Larisa H. Cavallari, University of Illinois at Chicago, Department of Pharmacy Practice, Chicago, Illinois, USA

Chair: James Halpert, University of California, San Diego, CA, USA 16:00 – 16:30

15:00 – 15:30 Implementing Personalized Medicine in an Electronic Medical Record Environment: Lessons Being Learned Dan Roden, Vanderbilt University School of Medicine, Nashville, Tennessee, USA

Structural Determinants of P450 Mediated Metabolism: A Moving Target Eric Johnson, Scripps Research Institute, Department of Molecular & Experimental Medicine, La Jolla, California, USA 16:30 – 17:00

15:30 – 16:00 Refreshment Break, Visit Exhibitors, View Posters

Arylamine N-Acetyltransferases from Structure to Mechanism

16:00 – 18:00

Edith Sim, University of Oxford, Kingston University, Oxford and Kingston, UK

PARALLEL SESSIONS 3 AND 4 PARALLEL SESSION 3: Regulation of Drug Transporter Expression and Function Chair: Micheline Piquette-Miller, University of Toronto, Toronto, Ontario, Canada 16:00 – 16:30 Evaluation of Drug Transporter Regulation during Drug Discovery and Development Joseph Ware, Genentech, South San Francisco, California, USA

Click to Register 13


17:00 – 17:30

11:00 – 13:00

Using Crystal Structures of Drug Metabolizing Enzymes in Mechanism-Based Modeling for Drug Design

PARALLEL SESSIONS 5 AND 6

Hao Sun, Pfizer, Inc., Department of Pharmacokinetics, Dynamics and Metabolism, Groton, Connecticut, USA

PARALLEL SESSION 5:

17:30 – 18:00

Metabolism, Pharmacokinetics and Interactions of Traditional Medicines and Natural Products

Can We Understand and Predict Ligand Binding to a Highly Flexible P450?

Co-Chairs: Chuan Li, Shanghai Institute of Materia Medica, Shanghai, China

James Halpert, University of California, San Diego, CA, USA

Ge Lin, Chinese University Hong Kong, School of Biomedical Sciences, Hong Kong, China

18:00

11:00 – 11:30

Young Investigators Reception

ADME/PK Studies of Herbal Medicines: What we Can Learn from Them

All students and postdoctoral attendees are invited to attend this reception.

Chuan Li, Shanghai Institute of Materia Medica, Shanghai, China

TUESDAY, OCTOBER 1, 2013 07:30 – 18:00

11:30 – 12:00 Assessment and Management of Adverse Effects and Hepatotoxicity Associated with the Metabolism of Herbal Products

07:30 – 18:00

Ge Lin, Chinese University Hong Kong, School of Biomedical Sciences, Hong Kong, China

Registration Open 07:45 – 08:45

12:00 – 12:30

Industry-Sponsored Symposia

Interactions Between Medicinal Phytochemicals and Drug Metabolism Enzymes (Phases I and II)

09:00 – 10:30

PLENARY SESSION 2:

Ling Yang, Dalian Institute of Chemical Physics, The Chinese Academy of Sciences, Liaoning, China

Utility of Genetic and Epigenetic Technologies in Drug Development and Safety Assessment

12:30 – 13:00

Chair: Ann Daly, Newcastle University, Institute of Cellular Medicine, Medical School, Newcastle Upon Tyne, UK

Progress and Promise of Chinese Herbal Medicines: Lessons from the First EU-China Framework Programme Project GP-TCM

09:00 – 09:30

Olavi Pelkonen University of Oulu, Pharmacology & Toxicology, Oulu, Finland

Application of Next Generation Sequencing to Prediction of Serious Adverse Drug Reactions Thomas J. Urban, Duke University Medical Center, Durham, North Carolina, USA

PARALLEL SESSION 6:

09:30 – 10:00

Chair: Yvonne Will, Pfizer, Global Research and Development, Groton, Connecticut, USA

Cell Type Specific Mechanisms of Adverse Drug Reactions

Genetics and Drug Repositioning Philippe Sanseau, GlaxoSmithKline, Computational Biology, Stevenage, UK

11:00 – 11:30

10:00 – 10:30

Yvonne Will, Pfizer, Global Research and Development, Groton, Connecticut, USA

In vitro Approaches to Detect Drug Induced Organ Toxicities- Learnings and Future Perspective

Immunogenetic Risk Factors for Adverse Drug Reactions and the Underlying Mechanisms Yuan-Tsong Chen, Academia Sinica, Institute of Biomedical Sciences, Taipei, Taiwan

11:30 – 12:00 Reactive Metabolite Formation in the Skin and the Mechanism by Which It Causes a Skin Rash

10:30 – 11:00

Jack Uetrecht, University of Toronto, Faculty of Pharmacy, Toronto, Ontario, Canada

Refreshment Break, Visit Exhibitors, View Posters 14


12:00 – 12:30

10:00 – 10:30

Role of Species- and Cell Type-Specific Expression of Membrane Transporters in Nephrotoxicity

DNA and Protein Adducts as Biomarkers of Exposure to Environmental and Dietary Toxicants

Lawrence Lash, Wayne State University School Of Medicine, Department of Pharmacology, Detroit, Michigan, USA

Robert Turesky, Wadsworth Center, Niskayuna, New York, USA 10:30 – 11:00

12:30 – 12:45

Refreshment Break, Visit Exhibitors, View Posters

Oral Presentation from Selected Abstract Poster

11:00 – 13:00

12:45 – 13:00

PARALLEL SESSIONS 7 AND 8

Oral Presentation from Selected Abstract Poster

PARALLEL SESSION 7:

13:00 – 14:00

Targeted Drug Delivery for Enhanced Therapy

Lunch (on own), Visit Exhibitors, View Posters

Chair: Christine Allen, University of Toronto, Toronto, Ontario, Canada

14:00 Free Afternoon in Toronto

11:00 – 11:30

Visit www.issx.org/international2013/Toronto for more information on things to see and do in Toronto.

Cancer Targeting Delivery of Nanomedicine and its Augmentation Based on the EPR-effect for Treatment and Imaging of Cancer by Using Fluorescence Endoscope

Hiroshi Maeda, Sojo University, Ikeda, Japan

WEDNESDAY, OCTOBER 2, 2013 07:30 – 22:00

11:30 – 12:00 07:30 – 18:00

To Be Announced

Registration Open

Shana Kelley, University of Toronto, Toronto, Ontario, Canada

07:45 – 08:45

12:00 – 12:30

Industry-Sponsored Symposia

Optimizing Delivery of HER2-targeted Liposomal Doxorubicin (MM-302) through Imaging, Computational Analyses and Experimentation

09:00 – 10:30

PLENARY SESSION 3:

Bart Hendriks, Merrimack Pharmaceuticals, Cambridge, Massachusetts, USA

Identification and Use of Novel Biomarkers for Xenobiotic-Induced Toxicity

12:30 – 13:00

Chair: Malle Jurima-Romet, Celerion, Drug Development, Hudson, Quebec, Canada

Drug Targeting with Nanoparticles Arto Urtti, University of Helsinki, Helsinki, Finland

09:00 – 09:30

PARALLEL SESSION 8:

Mechanism-based Biomarkers for Drug-induced Liver and Kidney Injury

Use of PB-PK Modeling in Pharmaceutical Safety Assessment

B. Kevin Park, University of Liverpool, Institute of Translational Medicine, Liverpool, UK

Chair: Aleksandra Galetin, University of Manchester, Manchester, UK

09:30 – 10:00

11:00 – 11:30

Insights from Healthy Volunteer Studies

Translational Modeling and Safety Assessment of Transport-Mediated Pharmacokinetics and Drug-Drug Interactions

Paul Watkins, Hamner-University of North Carolina Institute for Drug Safety Sciences, Research Triangle Park, North Carolina, USA

Aleksandra Galetin, University of Manchester, Manchester, UK

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11:30 – 12:00

15:00 – 15:30

Coupling in vitro Studies and PBPK Modeling to Predict Human Safety and Efficacy

The 2012 EMA DDI Guideline: The Most Important Updates and Post-adoption Experiences

Harvey Clewell, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina, USA

Eva Gil Berglund, Medical Products Agency, Uppsala, Sweden 15:30 – 16:00

12:00 – 12:30

An Industry Perspective and Experience on the Most Recent Regulatory DDI Guidelines

Physiologically Based Toxicokinetic Modeling as a Tool to Support Risk Assessment

Thomayant Prueksaritanont, Merck, Preclinical DMPK, West Point, Pennsylvania, USA

Ursula Gundert-Remy, Drug Commission of the German Medical Association, Berlin, Germany

16:00 – 16:30

12:30 – 12:45

Strategies to Assess Human Metabolism of NCEs - 5 Years After the MIST Guidances

Oral Presentation from Selected Abstract Poster

Greg Slatter, Amgen, Seattle, Washington, USA 12:45 – 13:00 Oral Presentation from Selected Abstract Poster

PARALLEL SESSION 10: Toxicogenomic and Metabolomic Profiling: Current Status and Future Utility in Assessing Drug Efficacy and Safety

13:00 – 14:30 Lunch (on own), Visit Exhibitors, View Posters

Tim Zacharewski, Michigan State University, East Lansing, Michigan, USA

14:30 – 16:30

PARALLEL SESSIONS 9 AND 10

14:30 – 15:00

PARALLEL SESSION 9:

Hans Westerhoff, University of Manchester, Manchester, England, UK

To Be Announced

Regulatory Perspectives in Drug-Drug Interactions and Metabolites in Safety Testing

15:00 – 15:30

Greg Slatter, Amgen, Seattle, Washington, USA

Integrated Examination of Ah Receptor-Mediated Hepatic Fat Accumulation

14:30 – 15:00

Tim Zacharewski, Michigan State University, East Lansing, Michigan, USA

Scientific Perspectives on Drug Interaction Evaluation During Drug Development Lei Zhang, FDA, CDER, Office of Clinical Pharmacology, Silver Spring, Maryland, USA

15:30 – 16:00 To Be Announced Rima Kaddurah-Daouk, Duke University, Durham, North Carolina, USA 16:00 – 16:30 Mechanistic Understanding and Biomarkers for Drug Toxicity Using Metabolomics Lining Guo, Metabolon, Durham, North Carolina, USA 16:30 – 17:00 Refreshment Break, Visit Exhibitors, View Posters 19:00 – 22:00 ISSX Party at the Hockey Hall of Fame This is a ticketed event. Be sure to purchase your ticket when registering online at www.issx.org/international2013/registration.  

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THURSDAY, OCTOBER 3, 2013 08:30 – 13:00

11:30 – 12:00 Molecular Imaging for Pharmacokinetics Tomotaka Shingaki, RIKEN Center for Life Science Technologies, Kobe, Japan

08:30 – 13:00 Registration Open

12:00 – 12:30

09:00 – 10:30

Molecular Imaging of Drug Target Molecules

PLENARY SESSION 4:

Tetsuya Suhara, National Institute of Radiological Science, Chiba, Japan

Genetically Modified Animal Models for Predicting Human Drug Disposition and Response

12:30 – 13:00

Chair: Xinxin Ding, Wadsworth Center, NYSDOH, Albany, New York, USA

MALDI Imaging MS: The Emergence of Molecular Histology in Drug Development Stephen Castellino, GlaxoSmithKline, PTS DMPK, Research Triangle Park, North Carolina, USA

09:00 – 09:30 PXR- and PPARα-humanized Mouse Models

PARALLEL SESSION 12:

Frank Gonzalez, National Cancer Institute, Laboratory of Metabolism, Bethesda, Maryland, USA 09:30 – 10:00

Development and Uses of Hepatocyte-Derived and Hepatocyte-Like Cells for Predicting Human Drug Metabolism

UGT-humanized Mouse Models

Chair: Martine Daujat-Chavanieu, INSERM, Montpellier, France

Robert Tukey, University of California, San Diego, La Jolla, California, USA

11:00 – 11:30

10:00 – 10:30

Modeling Hepatic Development, Metabolic Disorders and Drug Reactivity Using Hepatic-like Cells

Mouse Models for Drug Transporters

Nicholas Hannan, University of Cambridge, Cambridge, UK

John Schuetz, St. Jude Children’s Research Hospital, Pharmaceutical Science, Memphis, Tennessee, USA

11:30 – 12:00 Industrial Production of Functional Human Pluripotent Stem Cell Derived Hepatocytes: Applications and Comparison to Other Hepatocyte Models

10:30 – 10:45

POSTER AWARDS This meeting features a Predoctoral and Postdoctoral Poster Awards Competition. Visit www.issx.org/international2013/ abstracts to submit an abstract for this competition by the deadline of Friday, May 31, 2013.

Petter Björquist, Cellectis Stem Cells, Cellartis AB, Göteborg, Sweden 12:00 – 12:30 Generation of Metabolically Functioning Hepatocytes from Human Pluripotent Stem Cells by Transduction of FOXA2 and HNF1a

10:45 – 11:00 Refreshment Break

Hiroyuki Mizuguchi, Osaka University, Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka, Japan

11:00 – 13:00

PARALLEL SESSIONS 11 AND 12

12:30 – 13:00

PARALLEL SESSION 11:

Impact of Environmental Chemicals on the Differentiation of Human Adult Hepatic Progenitors

Tissue Imaging and Distribution Studies in Drug Development

Martine Daujat-Chavanieu, INSERM, Montpellier, France

Chair: Yasuyoshi Watanabe, RIKEN Center for Life Science Technologies, Kobe, Japan

13:00

CLOSING REMARKS

11:00 – 11:30 Molecular Imaging for Drug Development Yasuyoshi Watanabe, RIKEN Center for Life Science Technologies, Kobe, Japan

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International

GENERAL INFORMATION

IMPORTANT DATES Attendees:

Exhibitors:

•S  tudent Award Competition and General Poster Abstract Submission Deadline: Friday, May 31, 2013 www.issx.org/international2013/abstracts

• Exhibit Space Cancellation Deadline: Friday, June 28, 2013 Email: meetings@issx.org • Exhibitor Descriptions and Logos Due: Wednesday, July 31, 2013 Email: meetings@issx.org

• T ravel Grant Application Deadline: Thursday, June 6, 2013 www.issx.org/international2013/travelgrant

• Exhibitor Sponsorships and Advertising Placement Deadline: Wednesday, July 31, 2013 www.issx.org/international2013/exhibits

• Early Registration Deadline: Friday, June 28, 2013 www.issx.org/international2013/registration

• Industry Sponsored Symposia Application Deadline: Tuesday, August 13, 2013 www.issx.org/international2013/iss

• ISSX Awards Nomination Deadline: Sunday, June 30, 2013 www.issx.org/awards/nominations

• Exhibit Staff Registration Deadline: Friday, September 13, 2013 Email: information@issx.org

• Hotel Reservation Deadline: Friday, August 30, 2013 www.issx.org/international2013/accommodations • Attendee Registration Cancellation Deadline: Friday, August 30, 2013 Email: information@issx.org

To review the full exhibit and sponsorship opportunities, please visit

• Last Day to Pre-Register: Friday, September 27, 2013 www.issx.org/international2013/registration

www.issx.org/international2013/exhibits.

SPECIAL EVENT ISSX Party at The Hockey Hall Of Fame Enjoy a delicious standing buffet, catch up with friends, and meet new acquaintances at the Hockey Hall of Fame! Located in an architecturally ornate former bank building in downtown Toronto, the Hockey Hall of Fame is only four blocks from the Westin Harbour Castle. This spectacular museum is a highly unique venue that presents Canada’s national sport through the world’s largest collection of hockey artifacts and the fun of interactive games. Attendees can take shots at real-time goalies, stop the shots of Gretzky and Messier, call the play-by-play of some of hockey’s greatest goals, get up close and personal with the Stanley Cup in the museum’s vault, and explore the largest collection of hockey memorabilia in the world. Be sure to select this registration option and plan to attend the premier social event of the 10th International ISSX Meeting. Please note: this event requires the purchase of an event ticket for $100 USD. Be sure to select this registration option and plan to attend the premier social event of the 10th International ISSX Meeting.

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TRAVEL GRANTS

HOTEL INFORMATION

Students and postdocs as well as scientists from disadvantaged nations may apply for consideration of travel grant awards. ISSX recognizes the considerable benefit that scientists from disadvantaged nations, students, and others can gain from attending this important meeting and is proud to continue the travel grant program.

ISSX has secured a discounted room rate of $215 CAD single/ double at The Westin Harbour Castle Hotel. Attendees will enjoy this landmark waterfront hotel located in vibrant downtown Toronto on Lake Ontario, near major attractions including the Air Canada Centre, CN Tower, the Hockey Hall of Fame, and Toronto’s financial and theatre districts. This AAA Four Diamond Award hotel offers easy highway access and is less than 30 minutes from Pearson International Airport. Located 28 km from Pearson International Airport (YYZ), the hotel is easily accessible by airport shuttle, public transportation, taxi, and rental car.

Eligible Candidates for Travel Grants will be: • Scientists from disadvantaged nations or students or postdocs • Members of ISSX (or applying for membership along with submission of their grant application)

Reserve your accommodations online at https://www.starwoodmeeting.com/book/is17a or by telephoning the hotel directly at +1-800-937-846 1. Be sure to mention the ISSX 10th International Meeting in order to receive the discounted rate. Book online by Friday, August 30, 2013 to obtain the special ISSX attendee rate. We strongly encourage attendees to reserve accommodations as soon as possible in order to secure a room at our discounted rate.

Applicants for Travel Grants must also: • Submit an abstract and present a poster at the 10th International ISSX Meeting • Provide evidence in their application of active involvement in or contribution to ISSX activities (e.g., active recruitment of new members may be an advantage) Please visit www.issx.org/international2013/travelgrant for access to the online grant submission form and funding program deadlines. Travel grant applications are due to ISSX by Thursday, June 6, 2013.

Why you should stay at the Westin Harbour Castle • Competitive Rates – Negotiated hotel rates tend to be less expensive and restrictive than those found on the Internet, which sometimes require full payment at the time of booking. • Convenience – Most events will be held in the hotel, and there are multiple dining options available on site. You will be able to easily network with other attendees and get easily to and from the sessions.

AWARDS Nominations are now being accepted for the following awards to be presented at the 10th International ISSX Meeting. The awards to be presented at the 2013 International Meeting are:

• Keeping Cost of Attendance Down – Based on the number of rooms booked in ISSX’s block of rooms, the hotel provides complimentary or reduced rates for meeting room space, staff accommodations, and food and beverage charges. These savings are passed onto attendees and exhibitors through reasonably priced exhibit and registration fees.

The R.T. Williams Distinguished Scientific Achievement Award - Sponsored by Charles Crespi and Family. Presented to an ISSX member or non-member from any region who has made substantial and seminal scientific contributions to the field over a sustained period. The focus of this award is the individual’s scientific accomplishments and it is intended to recognize the best in the field, internationally. The award will consist of a plaque/medal, an honorarium and travel support, and will be presented along with a lecture once every three years in conjunction with the Society’s International Meeting.

More travel information is available at www.issx.org/international2013/accommodations.

VISA INFORMATION Letter of Invitation and Travel Documents

The Frederick J. Di Carlo Distinguished Service Award.

Please check with your local embassy/consulate or travel agent to obtain information regarding visa requirements. To request a Letter of Invitation from ISSX to help facilitate visa arrangements, please view the visa information page on the ISSX web site at www.issx.org/visa.

Presented to an ISSX member from any region who has a record of important service to the Society and its goals. The award will consist of a plaque or medal, honorarium and travel support and will normally be presented in conjunction with the appropriate international meeting. On occasion, one or two outstanding acts of service will justify the award or a long record of many acts of service without any single outstanding act will be recognized. Preferably, however, the recipient should have a record of many accomplishments some of which are major. The award will not be given for future promise, but on the basis of past service. The President-Elect and President of ISSX will be ineligible for the award for five (5) years after their term of office.

MEETING VENUE The Westin Harbour Castle, Toronto 1 Harbour Square Toronto, M5J 1A6, Canada (416) 869-1600 westinharbourcastletoronto.com

Nominations are due Sunday, June 30, 2013. Submit nominations at www.issx.org/awards/nominations.

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OPENING WELCOME RECEPTION

ATTIRE

All meeting attendees and their registered guests are invited to the Opening Welcome Reception on Sunday, September 29 from 19:00 – 21:00 in the Exhibit Hall.

The attire for this meeting is informal or business casual. A jacket and/or sweater is recommended for the meeting rooms and evenings in Toronto. Attire for the ISSX Party at the Hockey Hall of Fame is casual.  

ISSX PARTY AT THE HOCKEY HALL OF FAME

EXHIBITION INFORMATION

The 10th International Meeting will feature an exhibition showcasing the products and services that researchers need to advance their work. The exhibition begins with the Opening Welcome Reception on Sunday evening and continues throughout the meeting. Meet with representatives from top suppliers and maximize the value of your attendance!

Tour the Hockey Hall of Fame with colleagues and friends on Wednesday, October 2 from 19:00 – 22:00. Detailed information is available on page 18 of this brochure. A separate registration fee of $100 applies.

LANGUAGE

Companies interested in exhibiting, sponsoring, or advertising should download the Exhibitor Prospectus at www.issx.org/international2013/exhibits.

English is the official language of the 10th International ISSX Meeting. Translations will not be provided.

WEATHER

NEDMDG/ISSX WORKSHOP + INTERNATIONAL MEETING EXHIBITORS

The climate of Toronto is temperate. The September and October monthly averages are 14.5ºC / 58.1ºF daytime and 10ºC / 50ºF nighttime. Visitors should pack layers for a variety of temperatures.

ISSX thanks the following companies who exhibited at the April 2013 IDILI Workshop and will join our other vendors at this international meeting:

TIME ZONE The Time Zone in Toronto is Eastern Daylight Time and is four hours behind Greenwich Mean Time (GMT-4).

Celsis In Vitro Technologies Corning Life Sciences Hepregen Corporation LabLogic Systems, Inc. XenoBiotic Laboratories, Inc. XenoTech, LLC

ELECTRICITY The electricity voltage in Toronto is 110V. If traveling from outside of North America, bring a proper voltage converter and adapter to operate personal electrical appliances.

THINGS TO DO IN TORONTO Visit www.issx.org/international2013/Toronto to find more information about the city of Toronto.

BANKS AND CURRENCY EXCHANGE The currency in Toronto is the Canadian Dollar (CAD). Foreign currency can be exchanged at the airport or the front desk of your hotel. Local banks are open from 09:30 to 16:30, Monday through Friday. There are also private foreign exchange offices throughout the city that operate Monday through Saturday.

Registration is now open! Visit www.issx.org/international2013/registration. Register by June 28 to take advantage of the early registration discount!

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NOTICE OF APPROVED SATELLITE MEETING

Sixth International Workshop on the Arylamine N-Acetyltransferases Chestnut Conference Centre University of Toronto Toronto, Canada October 4 – 6, 2013 Meeting Organizing Committee: Denis Grant – Chair (Canada) Charlene McQueen (USA) Brunhilde Blömeke (Germany) Rodney Minchin (Australia) Sotiria Boukouvala (Greece ) Fernando Rodrigues-Lima (France) Neville Butcher (Australia) Edith Sim (UK) Jean-Marie Dupret (France) Kim Sugamori (Canada) Giannoulis Fakis (Greece) An officially recognized Satellite Meeting of the 10th International ISSX Meeting, The Sixth International Workshop on Arylamine N-Acetyltransferases will be held from the afternoon of Friday October 4 until noon on Sunday October 6, 2013 in Toronto, Canada. The NAT Workshops have been held since 1998, and they provide an informal venue for both young and established scientists from around the world to share the latest research related to these important Phase II drug-metabolizing enzymes and the chemicals upon which they act. The Sixth NAT Workshop immediately follows the 10th International ISSX Meeting. The Sixth NAT Workshop will be held at the University of Toronto’s Chestnut Conference Centre, in the heart of the downtown city core. It will consist of an opening Keynote Lecture, seven non-parallel Oral Presentation Sessions, one Nomenclature Discussion Session and one lunchtime Poster Session. We will attempt to give all registrants who submit a scientific abstract the opportunity to present their research in an Oral Presentation Session if they wish. There is also a Poster Session for those who prefer to present using this format, or if there is insufficient room to accommodate all oral speakers. The following are among the scientific topics that will be covered: • Metabolism, detoxication, bioactivation and toxicity of aromatic amines • NAT pharmacogenetics, polymorphisms and disease risk • NAT alleles, haplotype assignment and nomenclature • Novel functions of NAT proteins • Regulation of NAT gene expression • NAT structure-function relationships • NAT in microorganisms • Development and utility of NAT inhibitors If you have an interest in hearing or sharing information in these or any other emerging areas related to the NAT enzymes, then please visit the Sixth NAT Workshop website for further registration details and program updates. http://individual.utoronto.ca/grantlab

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issx toronto CMYK