and services. Managing knowledge is a critical driver for enhancing productivity that, in turn, offers higher and sustainable economic growth. Furthermore, regional integration can be a positive asset to develop a stronger knowledge-economy development model in the region, which will help expand trade and develop more efficient labor markets. In addition to structural reforms, CMI 2.0. recommends that governments in the region establish the appropriate conditions for the development of specific promising sectors and sites that can generate new activities and jobs. The development of dynamic “growth spots” will indeed help build trust and confidence in the new economic model and attract investments, economic activities and enhance knowledge sharing and innovation. Last, the implementation of a true knowledge and innovation-based development strategy requires a vision, strong coordination at the top level of government, and a participatory approach to mobilize the populations to back the needed reforms. Sustained strategic efforts are needed to obtain solid outcomes and to anchor the new practices so that they will endure over the medium to long term. The real challenge, especially for the private sector, is to develop more competitiveness and identify “niche markets” in the global economy.