IDEX Exclusive PAGES

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EXCLUSIVE

IDEX India is a leading manufacturer of highly engineered industrial products and technologies under the wellknown brand names of Fitzpatrick, Matcon, Micro uidics, Quadro and Steridose.

I am proud to know that every day we live the IDEX philosophy of 'Trusted solutions improving lives', helping our customers to create efficient, effective manufacturing systems that provide life-saving and lifeenhancing pharmaceuticals to our nation.”

We believe our success comes from relentless focus on our vision and values and the fact

DHIRAJ PANDIT

is Managing Director of MPT Asia responsible for supporting customers in Asia region

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that we care about the “how” as much as the “what”, as we lead and run our businesses.

Dec 2021 - Jan 2022


IDEX India

Global Expertise in Material Processing Technologies IDEX India is a subsidiary of the IDEX Corporation which was founded in 1987 and has become a global leader in applied solutions, with presence in ve continents, and more than 6,800 dedicated employees helping customers around the world. The products produced by the companies in the corporation touch our “We are able to not only provide customers with global products and system solutions, but we also have the autonomy to design and develop solutions that are speci c to our local

lives every day - whether it's a life-saving rescue operation, creating lifeenhancing pharmaceuticals or fuelling aircraft, IDEX is a leader in creating enabling technology used in many of the most common everyday activities. “We believe our success comes from relentless focus on our vision and values and the fact that we care about the “how” as much as the “what”, as we lead and run our businesses.” The team in India is based in a world class facility of 1,50,000 sq ft in Savli, Vadodara, India. The facility incorporates a highly effective, teamoriented environment that integrates design, engineering,

market and local

manufacturing, administration, and the industry's latest technology. “We

customer requirements.”

are able to not only provide customers with global products and system solutions, but we also have the autonomy to design and develop solutions that are speci c to our local market and local customer requirements.” The team comprises front-end sales, technical and service team who are highly quali ed. They are fully supported and networked with their colleagues located around the world, which helps everyone to keep in touch with not only the local needs, but global trends too. IDEX has a network of channel partners who further help it to support its local customers. IDEX team is just a call away – 1800 267 9955 (toll free).

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Dec 2021 - Jan 2022


EXCLUSIVE

Fitzpatrick and Quadro introduce one of the world's most advanced milling and screening platforms The SLS – Scalable Lab System™ is a unique benchtop laboratoryscale powder milling and screening platform that provides ve powder processing solutions from one base unit. Offering conical milling, hammer milling, high energy milling and screening technology, this is an ideal platform for reliable and repeatable testing, as well as for research within an R&D lab or start-up.

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Dec 2021 - Jan 2022

When it comes to scalable milling and powder processing technology, IDEX MPT technology is hard to beat. With solutions for the labscale investigative stage, the proof-ofconcept stage and full-scale production, there is a compatible solution that will grow with your company's success.


Milling & Screening

SLS – Scalable Lab System™

When it comes to scalable milling and powder processing technology, IDEX MPT technology is hard to beat. With solutions for the labscale investigative stage, the proof-of-concept stage and fullscale production, there is a compatible solution that will grow with your company’s success. The SLS – Scalable Lab System™ is a unique benchtop laboratoryscale powder milling & screening platform that provides ve powder processing solutions from one base unit. Offering conical milling, hammer milling, high energy milling and screening technology, this is an ideal platform for reliable and repeatable testing, as well as for research within an R&D lab or start-up. When it comes to scaling up and proof of concept work, the newly launched Mid-Size SDx™ Series affords provides the easiest path from research & development through to full production. Offering multiple milling and screening technologies on a single, common drive it offers a cost effective, space saving solution to commercial scale up. The Mid-Size SDx™ improves on-target PSDs by 30 – 50% over similar technologies. It is the rst conical mill and security screener with a greaseless gearbox in the pharmaceutical milling industry that safeguards batches for enhanced operator and product safety. Proprietary Comil® screen designs can improve processing efficiencies over comparable equipment. And now, with the introduction of the patented high-efficiency screens – capacity throughput can be increased by up to 50% and milling temperatures lowered by as much as 30%, depending on product and equipment set-up. This cutting-edge technology on a single common drive affords effective, reliable, efficient & scalable powder processing technology.

Mid-Size SDx™ Series

Production-Scale SDx™ Series

The Production-Scale SDx™ Series platform offers three distinct powder processing solutions on one common drive, providing the ability to easily transfer between conical milling, security screening and hammer milling, improving production efficiency and removing bottlenecks. Once again this platform has a greaseless gearbox offering reassurance of performance. All the platforms use SMARTdetect™ Technology which instantly recognizes the head being installed and automatically makes the necessary RPM modi cations, ensuring the equipment operates within the pre-set minimum and maximum RPM for each speci c technology. This enables the user to easily navigate between the various heads without the need of resetting complicated parameters.

Reduced Capital Investment & Cost of Ownership comes from the fact that each model offers multiple functionalities on a single common drive platform, offering the lowest long-standing cost when compared to the purchase of individual units. To learn more, visit https://www.idexindia.in/quadro/milling/ or give a call on 18002679955(Toll Free) or drop an email on info.fmt@idexcorp.com.

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Dec 2021 - Jan 2022


EXCLUSIVE

High Shear Mixers

Quadro Liquids Solving Processing Challenges

Quadro® Liquids group designs and manufactures single-pass, inline, high Furthermore, there is less degradation for speci c APIs. This all helps to improve efficiency and improve the performance of the downstream equipment. These models are fully scalable and have a variety of tooling available to handle the speci c requirements of both the lab and production environments.

shear mixer technology that is used for powder incorporation and

rotor-stator technology, for top quality results and reliability year after year.

One of the recent high volume applications was to help in the ght liquid-into-liquid mixing against Covid by supplying Quadro and homogenizing. High Shear Mixers for manufacturing Hand Sanitizer. To nd out more about the story visit: Bringing decades of knowledge https://www.quadroliquids.com/blo and applications experience to the Quadro® liquid blending and g/how-to-manufacture-handcustomer problem, Quadro® Liquids emulsi cation equipment is chosen sanitizer-using-high-shear-mixers. prides itself on being the mixer time and again due to its higher manufacturer that provides shear output compared to other solutions that other businesses cannot. dispersion into liquids,

Quadro® Liquids is solving the processing challenges of manufacturers involved in particle size reduction of API slurries. The Z Emulsi er and HV Emulsi er can improve particle and droplet size distribution, increase product yield and reduce milling time by reducing the number of passes.

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Dec 2021 - Jan 2022


EXCLUSIVE

Case Study

Know how a leading API customer signi cantly improved their product milling process OBSTACLES IN THE PROCESS User was running the Comil U30 machine without continuous feeding Granule size was large and its nature was hard Lot of heat was being generated API was sticky, leading to choking of screen holes

HOW WE SOLVED THEM Quadro team recommended not to stop Comil U30 during entire milling process Also the infeed was made controlled and continuous. This allowed the Comil for longer run and reduced the occurrence of screen holes blinding

“With the help of Our Quadro Team the API customer witnessed a signi cant improvement The existing process (404 kg) took 5 hours and now the new process took only approx. 45 minutes without screen choking and zero dusting”

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Witness How Our Maharashtra Based API Client Achieved UNITERRUPTED MILLING Through QUADRO L4 SERIES CONICAL MILL !

Quadro L4 Series Conical Mill !

Challenges Faced by Customer

Quadro Solution - L4 Series Cone Mill

Local Conical Mill was being used

Achieved out-put of 600kg/hr (3 times of the old mill)

Out-put was low (around 200kg/hr)

Achieved required PSD in single pass. Eliminated extra step of Classi cation sifting

Didn’t get required PSD in single pass, and hence they had to do classi cation process and re-milling of the coarser material

Saving of time due to elimination of Classi cation sifting

Choking of screen while milling with 0.5mm size

Uninterrupted milling. No choking found in 0.5mm screen


EXCLUSIVE

IBC Systems

Matcon considers the challenges you face both up and downstream and help you to install a system that will set you up for the future, increase the production output of granulation process equipment and improve pro tability.

MATCON

sets you up for the

FUTURE 43 PHARMA machines & technology

Dec 2021 - Jan 2022

For a pharmaceutical OSD producer, commonly the focus of attention is on the processing stages of granulation, compression, coating and packing. Often overlooked, or not considered early enough in the facility design process, is “How are the materials moved from one process step to another?” “What is the best way to do this?”


EXCLUSIVE

IBC Systems

Without fully considering these fundamental questions when designing a facility, the manufacturer not only risks compromising the productivity of a given product line, but also limiting future potential for expanding capability and capacity. Of course, there is not a 'one size ts all' solution to materials handling, but Matcon IBC systems are extensively used in the Indian and worldwide pharmaceutical sector for transferring powders, granules and tablets. The patented Cone Valve within each IBC can control even the most free- owing powders, right through to sticky materials, such as metformin, ensuring that the nished product contains the correct measures of ingredients. The valve opens, closes or shuts off the ow, regulating the amount of powder being discharged into the process below. If a problem occurs downstream, production doesn't need to stop, or batches changed.

· Are these methods cost and time effective? · Are you able to cope with uctuating future industry changes and demands? Now is the perfect time to reevaluate your pharmaceutical manufacturing operations and start preparing for your future.

a consistent, reliable feed of granules allows us to produce between 15-20% more from the Matcon fed lines as compared to the others.“ In the 40+ years' experience helping its customers remain competitive, Matcon has a unique understanding of the challenges you face in what is an everchanging industry. Matcon considers the challenges you face both up and downstream and help you to install a system that will set you up for the future, increase the production output of granulation process equipment and improve pro tability.

One of its esteemed Indian pharmaceutical clients recently commented: “We have been using To meet the pressures of consumer Matcon on our site since 2014 and and supplier demand, it is remain very happy with it. We have important to be agile if you're going two identical process units in to compete. Assess your current adjacent buildings, one which we facility processes by asking yourself: use Matcon IBCs to feed our · Are you using updated compression machines and one To nd out more visit technologies and exible which uses a conveying system. The https://www.idexindia.in/matcon/ equipment? ability of the Matcon IBC to provide

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Dec 2021 - Jan 2022


EXCLUSIVE

Case Study

INCREASE PLANT VOLUME by solving powder handling issues This case study is from a senior executive from one of the largest ARV manufacturer in the world

CHALLENGES Flow Issue: Issues with powder ow, downtime and waste Bridging Issue: Due to butter y valve, product would regularly bridge in the container; Operators had to hammer the bins to stimulate powder ow Intermittent Flow: Intermittent powder ow to tablet compression: this regularly choked the butter y valve Required Cleaning: Regular cleaning was required following each batch resulting in larger downtime Additional Manpower: Operators were diverted from core tasks onto cleaning duty

OUR SOLUTION IBC with CONE VALVE TECHNOLOGY Consistent Flow: Stimulated consistent powder ow to tablet press Reduced Handling: Reduced manual handling so that operators time is well used Eliminate Bridging Issues: Powder recipe was stopped from bridging in the container, no need of hammering Increased Production: The speed of tablet production was increased

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Dec 2021 - Jan 2022



EXCLUSIVE

Fluid Processors

Microfluidics USP TOP PRODUCTS

Micro uidizer® processors are more than simply high-shear uid processors – they are designed speci cally for the pharma & biotech industries to create advanced biopharma and pharmaceutical products. Currently, some of our customers are using Micro uidizer® technology to produce cuttingedge vaccines with advanced adjuvant production and LNP delivery systems particularly for Covid-19 vaccine development. In Covid vaccine production, LNPs exhibit strong efficacy and functionality in their ability to deliver fragile mRNA intact and to its target site. Micro uidizer® technology is a proven technology in LNP production because of its ability to achieve precise particle size control. By reducing the particle size from the micron to the nano range scale, LNPs are able to achieve an efficient drug delivery so particles can be quickly released into the target site. As an injectable drug, these mRNA vaccines are required to be sterile

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which can be a costly process. Through Micro uidizer's® technology, very narrow particle size nanoparticles are created and can pass through sterilizing lters without losing product or clogging the equipment which hinders production. For vaccine production, the ability to achieve desired results in the laboratory is successful only if the results can be repeated and produced for global distribution. Micro uidizer® technology is scalable by aligning microchannels in parallel within the Interaction Chamber™, with a single output reservoir. This ensures that the entire product stream experiences identical shear, resulting in consistent quality. Therefore, the same results are repeatable batchto-batch. As an example of how Micro uidics offers a scalable solution in RNA delivery, watch our recent webinar (https://www.micro uidicsmpt.com/blog/a-scalable-solutionfor-the-creation-of-lipidnanoparticles-for-rna-delivery) and see how our customer achieved revolutionary, repeatable results on

Dec 2021 - Jan 2022

our M110P and pilot processors and will ultimately scale to our M700 production series. Last year, we installed an M815 Micro uidizer® processor in India for the production of Liposomal Amphotericin B to produce emergency doses to cure mucormycosis, using this powerful, intravenous anti-fungal medicine. The M815 was selected due to its ability to create on-target nanoparticles with a narrow particle size distribution, which is critical for producing consistent, reliable product. A further application of Micro uidizer® technology is in the production of nab paclitaxel. As this requires precise particle size control the uniform high shear generated during processing produces repeatable results, a high quality nanoemulsion and tight particle size distributions. If you would like to nd out more: (https://www.micro uidicsmpt.com/applications/nanoparticl e-albumin-bound-nab-drugdelivery


EXCLUSIVE

Testimony

SUCCESS Story

In 2011, Gennova purchased an Aseptic M110EH30, Serial No. 2011106 processor. Since then, in times of need, MF team (both USA and India) has provided excellent support whenever needed, even repeatedly ying factory engineers to site to resolve issues earlier this year.

“We are thankful and appreciate Micro uidics for their commitment & continuing supports extended to us, and highly recommend them to the other customers looking for an aseptic solution”. - Swarnendu Kaviraj Vaccine Formulation and Research Center Gennova Biopharmaceuticals Ltd.

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When creating nanoemulsions for intravenous therapeutics, a target nanoparticle size and narrow particle size distribution is critical for achieving consistent results.

Micro uidizer® technology is compliant with cGMP regulations and has been found to be both fast and efficient in the reduction of liposome vesicles.

Micro uidizer® processors deliver uniform high shear during processing. This controlled precision allows for repeatable results regardless of volume size.


EXCLUSIVE

FITZPATRICK

Powder processing innovation excellence

Committed to improving the performance and pro tability of its customers' powder processing operations, The Fitzpatrick Company continually invests in customer-driven innovative solutions.

For over 80 years, Fitzpatrick has consistently achieved powder processing innovation excellence. They have designed, manufactured, and supplied the CCS and IR range of roller compactors as well as FitzMill™ milling equipment and hammer mills, to the

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pharmaceutical, chemical and food sectors worldwide. Committed to improving the performance and pro tability of their customers' powder processing operations, they continually invest in customer-driven innovative

Dec 2021 - Jan 2022

solutions and provide long-term support via their highly technical customer service and spare parts network.


The available 20 kN/cm roll pressure is equivalent to productionscale systems and matches the requirement for most pharmaceutical blends, so the results you achieve are a true re ection of a powder's suitability for dry granulation.

CCS1025

For more information go to https://www. tzpatrickmpt.com/products/benchtop-dry-granulation

CCS520

Manufactured with Fitzpatrick's high-precision, twin feed screw system, the LCS processes powders using the same mechanism as larger production-scale systems. This capability produces a compact that is comparable to that produced on full-sized models, which ensures your development projects can progress to production with con dence.

CCS720

Introducing the newest model in the roller compaction range LCS – Lab Compaction System, a scalable benchtop, high performance model for R&D and trial batch production. With capacities ranging from 10g to 6 kg/hr, the new LCS is ideal for proof-of-concept work or for smallest volume production.

CCS320

CCS220

LCS

Powder Processing

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Dec 2021 - Jan 2022


EXCLUSIVE

Powder Processing

LAB COMPACTION SYSTEM (LCS) Ideal for proof-of-concept or smallest volume production. Bene ts Manufactured with Fitzpatrick high-precision, twin feed screw system 20 kN/cm roll pressure equivalent to production-scale systems Complete disassembly of all contact parts enables thorough cleaning that is quick & easy Touchpad control of all independent feed & compaction variables Consistent compaction mechanism ensures easy scale-up to larger production machines Design optionally available for containment systems Documentation available for cGMP software option Choice of roller styles for maximum exibility

Features at a glance ROLL DIMENSIONS ROLL FORCE MINIMUM CAPACITY CAPACITY

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1.5 X 12 cm 20 kN/cm 10 g 6 kg/hr*



EXCLUSIVE

Why customers value

STERIDOSE MAGNETIC MIXER Steridose Magnetic Mixer has become the trusted solution for demanding hygienic and sterile applications such as those involving serums, vaccines, plasma fraction, bacteria and cell cultures and APIs. Steridose have utilized over 4 decades of manufacturing experience to produce the most dependable and advanced solutions for its customers. The mission is to employ its technical understanding and application knowledge to develop equipment that surpasses the growing demands of both biotech and pharmaceutical manufacturers.

applications such as those involving serums, vaccines, plasma fraction, bacteria and cell cultures and APIs. Magnetic mixers have become the

The Sterimixer is ideal for demanding hygienic and sterile

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trusted solution for applications where sterility cannot be compromised – all the liquid is contained and isolated.


Magnetic Mixer

High levels of Containment and Isolation · Increased yields with mixing to the last drop · Easy cleaning processes using standard CIP and SIP procedures · Compact design – no overhead equipment needed · Simple maintenance – safe and easy impeller and drive unit removal. · Gas entrainment and foaming is greatly reduced by the offset mixer mounting. The Sterimixer Magnetic Coupled mixer has the highest number of installations around the world. One of its customers is a contract manufacturer producing a wide variety of cough syrups. As their business steadily grew, they needed four new tanks. Instead of doing things the same old way, they were looking for a way to make their

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process more hygienic. They approached Steridose to help them design an upgrade of their mixing process. Like any contract manufacturer, they needed exibility - they may be making a 200 centipoise cough syrup today and they may get a contract for a 500 centipoise cough syrup tomorrow, the speci c gravity varying with each recipe.

High levels of Containment and Isolation · Increased yields with mixing to the last drop · Easy cleaning processes using standard CIP and SIP procedures · Compact design – no overhead equipment needed

· Simple maintenance – safe and easy impeller and drive unit Steridose's engineers used the data removal. provided by the customer to arrive · Gas entrainment and foaming is at a mixer selection that provides greatly reduced by the offset mixer the customer with not only a mounting. solution for their new tanks, but one that added in a reasonable The Sterimixer Magnetic Coupled amount of mixing in reserve, so that mixer has the highest number of they are future-proofed for installations around the world. One continued growth and expansion. of its customers is a contract To nd out more about this story go to: https://www.steridose.com/blog/m aking-cough-syrup-with-magneticcoupled-mixers.

Dec 2021 - Jan 2022

manufacturer producing a wide variety of cough syrups. As their business steadily grew, they needed four new tanks. Instead of doing things the same old way, they were looking for a way to make their


C M Y K

Open Size width 8.5"

GLOBAL EXPERTISE

Open Size height 12.045"

in Material Processing Technologies

HIGH SHEAR FLUID PROCESSORS

SOLID DOSAGE POWDER / GRANULE, TABLET HANDLING SOLUTIONS HIGH SHEAR MIXER MANUFACTURER

PHARMA POWDER PROCESSING & SIZE REDUCTION EQUIPMENT

ROLL COMPACTION & DRY GRANULATION EQUIPMENT

Toll Free:1800 267 9955

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Oct - Nov 2021

info.fmt@idexcorp.com

STERIDOSE MAGNETIC MIXER

www.idexindia.in