Page 1

PATOLOGI SISTEMIK II (PAP 442)

PATOLOGI ALAT REPRODUKSI ALAT KELAMIN JANTAN Dr. drh. Eva Harlina, MSi. Bagian Patologi Departemen Klinik, Reproduksi dan Patologi Fakultas Kedokteran HewanHewan-IPB Jl. Agatis Kampus IPB Darmaga, Bogor - 16680


MALE REPRODUCTIVE SYSTEM

• Testis • Excretory duct • Accessory glands • Penis and pprepuce p

Patologi Alat Kelamin Jantan

2


MALE REPRODUCTIVE SYSTEM

• Testis Seminiferous tubules (contain germ cells in various stage of maturation), Sertoli cell, cell Leydig cells

• Excretory duct: duct: epididymis, vas deferens • Accessory glands glands:: seminal vesicles, prostate

• Penis and prepuce Patologi Alat Kelamin Jantan

3


Patologi Alat Kelamin Jantan

4


Patologi Alat Kelamin Jantan

5


Patologi Alat Kelamin Jantan

6


DISEASES OF THE MALE REPRODUCTIVE SYSTEM 

Developmental disorders

Diseases of the scrotum and contents

Diseases of the accessory glands

Diseases of the penis and prepuce

Patologi Alat Kelamin Jantan

7


DEVELOPMENTAL DISORDERS MAJOR ANOMALIES 

Sexual dimorphism p

Segmental aplasia of epididymis

Cryptorchidism

Testicular hypoplasia

Spermatic granuloma Patologi Alat Kelamin Jantan

8


SEXUAL DIMORPHISM Errors of chromose, gonadal or phenotypic sex 1. Sex chromosomes (structure and number). a. Abnormal structure of Y (isochromosome) Female phenotype H Hypoplasctic l ti gonads d b. Duplication of one of the sex chromosome (XXY, XYY) Testicular hypoplasia Kli f lt ’ syndrome Klinefelter’s d (tricolor (t i l male l cat) t) Patologi Alat Kelamin Jantan

9


SEXUAL DIMORPHISM …

2 Hermaprhodites 2.

• XY genotype • Androgen receptor disorder • Abnormal gonads (have both testicular test cu a a and do ovarium a u ttissue) ssue)

Patologi Alat Kelamin Jantan

10


Male pseudo pseudohermaphrodite: XY chromosome

Patologi Alat Kelamin Jantan

11


Patologi Alat Kelamin Jantan

12


MINOR ANOMALIES

Patologi Alat Kelamin Jantan

12


MINOR ANOMALIES

Patologi Alat Kelamin Jantan

13


DISEASES OF THE SCROTUM AND CONTENTS 

The scrotum

T i and Testis d Epididymis E idid i

Patologi Alat Kelamin Jantan

14


DISEASES OF THE SCROTUM ď‚˜

Dermatitis Trauma Trauma Frosbite E i Environmental t l iirritants it t Chorioptes bovis

ď‚˜

Neoplasma p Mast cell tumor Melanoma Hemangioma Patologi Alat Kelamin Jantan

15


Patologi Alat Kelamin Jantan

16


Patologi Alat Kelamin Jantan

17


DISEASES OF TESTIS AND EPIDIDYMIS Decreased size 

C t hidi Cryptorchidism

Hypoplasia yp p

Testicular degeneration

Segmental aplasia

Patologi Alat Kelamin Jantan

18


Increased size 

Spermatic granuloma of epididymis

Epididymitis

Orchitis

Testicular neoplasia: Seminoma Sertoli cell tumor Interstitial cell tumor Patologi Alat Kelamin Jantan

19


Decreased size …

CRYPTORCHIDISM Incomplete descent of testis

Oft unilateral Often il t l

Hypoplasia or atrophy

Testis is small, fibrotic, hyaline thickening of tubular basement membrane membrane, degeneration of germinal epithelium, only a few spermatogonia remain remain, normal Sertoli cells

Prone P tto neoplasia l i (S (Sertoli t li CT CT, seminoma) i ) Patologi Alat Kelamin Jantan

20


Patologi Alat Kelamin Jantan

21


Patologi Alat Kelamin Jantan

22


Decreased size …

HYPOPLASIA 

Mild to severe

Unilateral hypoplasia

Ab Abnormality lit off specific ifi genes, endocrine, d i cytogenic

Related to poor general nutrition, Zn deff

HP: hypoplastic tubules, lined by sertoli cells, a few stem cells and spermatogonia Patologi Alat Kelamin Jantan

23


Patologi Alat Kelamin Jantan

24


Decreased size … 

TESTICULAR ATROPHY Reduce in size after puberty

Testicular degeneration

HP: deg. of the seminiferous tubules

Causes by: inflammation, obstruction of flow of spermatozoa (segmental aplasia, injury of epididymis, torsion of spermatic cord)

Systemic injurious factor: hypovitaminosis A, Zn, antibiotic, toxins, estrogen produced by sertoli cell tumor Patologi Alat Kelamin Jantan

25


Some Causes of Testicular Degeneration              

Advancing age Epididymitis Chemicals Heat Hormones Metal compound toxicosis Neoplasia Nutritional disorders Plants Radiation Stress Trauma Ultrasound Viral infection Patologi Alat Kelamin Jantan

26


Patologi Alat Kelamin Jantan

27


Patologi Alat Kelamin Jantan

28


EPIDIDYMITIS AND SPERMATIC GRANULOMA 

Inflammation, testicular neoplasia

Spermatic granuloma: congenital obstruction inflammation as respon to obstruction, spermiostatis

Epididymitis is almost accompanied by spermatic granuloma and periorchitis

Cause testicular degeneration

B. abortus, E. coli Patologi Alat Kelamin Jantan

29


Patologi Alat Kelamin Jantan

30


Increased c eased ssize e 

Spermatic granuloma of epididymis

Epididymitis

Orchitis

Periorchitis

Testicular neoplasia S i Seminoma Teratoma Sertoli cell tumor Interstitial cell tumor

Patologi Alat Kelamin Jantan

31


Patologi Alat Kelamin Jantan

32


Patologi Alat Kelamin Jantan

33


Patologi Alat Kelamin Jantan

34


ORCHITIS 

Extension of epididymitis

Hematogenous

B abortus, B. b t B B. suis, i C. pseudotuberculosis

Intratubular orchitis, necrotizing orchitis, granulomatous l t orchitis hiti (M. (M bovis, b i mycotic orchitis) orchitis) Patologi Alat Kelamin Jantan

35


Patologi Alat Kelamin Jantan

36


Patologi Alat Kelamin Jantan

37


TESTICULAR NEOPLASIA 

Common in older dog g

Arise from germ cells

Seminoma

I t titi l cellll ttumors Interstitial

Sertoli cell tumors: feminizing effect (Gynecomastica Gynecomastica:: enlargement of mammary gland) Patologi Alat Kelamin Jantan

38


Patologi Alat Kelamin Jantan

39


Patologi Alat Kelamin Jantan

40


Patologi Alat Kelamin Jantan

41


Patologi Alat Kelamin Jantan

42


Veneric Sarcoma Kulit hingga ke mukosa Sel tumor menyebar seperti anggur

8


stroma

stroma

9


10


Sertoli Cell Tumor Stroma menebal

Tubuli seminiferi berisi sel Sertoli yang berproliferasi

11


Ukuran tubuli seminiferi bervariasi: membesar, membesar mengecill

Stroma menebal 12


Sel Sertoli

13


slide traktus urogenital jantan  

pertemuan 1 (belum lengkap)

Advertisement
Read more
Read more
Similar to
Popular now
Just for you