Page 1

Premium Recombinant Cytokines Animal-Free Product Line GMP-Compliant/Ancillary Product Line As the leading manufacturer of a complete range of cytokine products, PeproTech proudly provides customers with an extensive selection of products that guarantee the highest standards of quality, consistency, reliability and value for life science research needs.

www.peprotech.com


Animal-Free Product Line PeproTech’s animal-free product line is designed to minimize potential risks that arise from the presence of trace amounts of animal-derived adventitious agents such as viruses, TSE/BSE and unknowns. Expressed in E.coli bacterial culture, animal-free recombinant proteins are manufactured in a dedicated animal-free facility under strict animal-free conditions where the production protocols have been modified to include only animal-free reagents and chemicals. All product contact material is also qualified as animal component free. PeproTech’s animal-free proteins maintain identical high biological activity and purity to the corresponding proteins that are produced using standard techniques to provide the quality capable of equaling or enhancing the performance of animal-derived media formulations. Product Catalog# Animal-Free Human Recombinant Proteins Activin A* AF-120-14E BD-5 AF-300-68 BAFF AF-310-13 BDNF AF-450-02 BMP-4 AF-120-05ET EGF AF-100-15 FGF-acidic AF-100-17A FGF-basic AF-100-18B FGF-4 AF-100-31 FGF-8 AF-100-25 FGF-9 AF-100-23 FGF-10 AF-100-26 Flt3-Ligand AF-300-19 G-CSF AF-300-23 GDF-3 AF-120-22 GDNF AF-450-10 GM-CSF AF-300-03 Heregulinβ-1 AF-100-03 IFN-γ AF-300-02 IFN-λ1 AF-300-02L IGF-I AF-100-11 IGF-II AF-100-12 IL-1α AF-200-01A IL-1β AF-200-01B IL-2 AF-200-02 IL-3 AF-200-03 IL-4 AF-200-04 IL-6 AF-200-06 IL-7 AF-200-07 IL-8 (72 a.a.) AF-200-08M IL-10 AF-200-10 IL-13 AF-200-13 IL-15 AF-200-15 IL-16 (121 a.a.) AF-200-16A IL-17 AF-200-17 IL-17E AF-200-24 IL-21 AF-200-21 IL-22 AF-200-22 Note: PeproTech’s Animal-free proteins are for research use only.

Products are lyophilized, most products with a minimum amount of salt, with no other additives or preservatives added. PeproTech’s animal-free products have a level of animal material exposure that is less than tertiary as defined by animal component-free products of the EMA (European Medicines Agency) guideline document. PeproTech’s animal-free product line is: • Manufactured in a dedicated animal-free facility • Free from animal-derived material throughout manufacturing processes • Available in the widest range of animal-free cytokines in the industry and continuously expanding • Available in custom sizes Product IL-31 IL-33 IL-36γ KGF/FGF-7 LIF M-CSF MCP-1 β-NGF NT-3 NT-4 PlGF-1 PDGF-AA PDGF-BB RANTES/CCL5 SCF SDF-1α/CXCL12 SDF-1β/CXCL12 TGF-α TGF-β3 TNF-α TPO TWEAK VEGF121 VEGF165

Catalog# AF-200-31 AF-200-33 AF-200-36G AF-100-19 AF-300-05 AF-300-25 AF-300-04 AF-450-01 AF-450-03 AF-450-04 AF-100-06 AF-100-13A AF-100-14B AF-300-06 AF-300-07 AF-300-28A AF-300-28B AF-100-16A AF-100-36E AF-300-01A AF-300-18 AF-310-06 AF-100-20A AF-100-20

* Activin A sequence among human, murine and rat is identical. Animal-Free Murine Recombinant Proteins FGF-basic AF-450-33 GM-CSF AF-315-03 IL-3 AF-213-13 IL-4 AF-214-14 IL-6 AF-216-16 M-CSF AF-315-02 SCF AF-250-03 TPO AF-315-14 Animal-Free Rat Recombinant Proteins GM-CSF AF-400-23 TPO AF-400-34


Available Soon

GMP-Compliant/Ancillary Product Line

PeproTech’s GMP-compliant/ancillary product line is a range of our highest standard cytokines intended for use in manufacturing cell therapy, gene therapy and tissue-engineered products for clinical applications. These ancillary materials will be manufactured in compliance with current Good Manufacturing Practices (GMPs), in certified ISO7 cleanrooms, under a rigorous quality system, without use of animal-derived materials. The production protocols were comprehensively developed to ensure the traceability, consistency, suitability, purity and safety of these products with GMP standard operating procedures. All aspects of manufacturing, QC testing, labeling and packaging will be stringently controlled, validated and monitored. PeproTech will further standardize and define these cytokines in USP (United States Pharmacopeia) monographs. This high degree of control and quality in manufacturing and testing provides customers with simplified use of these cytokines in ex vivo manufacturing processes, as described in USP Chapter <1043> Ancillary Materials for Cell, Gene, and Tissue-Engineered Products. PeproTech’s GMP-compliant/Ancillary product line is: • Manufactured in a GMP-compliant and ISO7 cleanrooms certified facility • Intended for use in manufacturing cell therapy, gene therapy and tissue-engineered products for clinical applications • Animal-free Note: PeproTech’s GMP-compliant/Ancillary proteins are not intended for direct administration to humans or animals.

PeproTech’s Quality Assurance PeproTech’s recombinant cytokines/proteins are subject to a rigorous set of quality control standards. Our Quality Assurance department ensures that the proteins demonstrate consistent molecular weights, N-terminal sequences, purity and biological activity. This quality control is devoted to providing consistency between lots and the following qualities. Authenticity All recombinant protein products are verified by N-terminal sequence analysis, SDS-PAGE and where possible by RP-HPLC and Mass Spectrometry analyses versus standards. Purity Verified by SDS-PAGE and where possible by RP-HPLC. Biological Activity Determined in the relevant in vitro and in vivo bioassay. Protein Content Verified by UV spectroscopy, SDS-PAGE and where possible by RP-HPLC. Endotoxin Contamination Tested by kinetic LAL (Limulus Amebocyte Lysate) method to ensure the lowest possible endotoxin levels and the highest purity. Sterility All products are sterile filtered through a 0.2 micron filter.


About PeproTech Established in 1988 by a group of scientists in New Jersey, USA, PeproTech is a privately owned biotechnology company focusing on the development and manufacturing of high quality cytokine products for the life-science and cell therapy markets. Over the past 25 years the company has grown into a global enterprise with state-of-the-art manufacturing facilities in the US, and customer service offices in Canada, Mexico, UK, France, Germany, Austria, Sweden, Israel, Korea and China. With over 2,000 products PeproTech has developed and refined innovative protocols to ensure quality, reliability and consistency. The products include E. coli, insect cell and mammalian cell-derived recombinant cytokines/proteins, their monoclonal/polyclonal antibodies, ELISA development kits, serum-free cell culture media and other cytokine-related reagents. Our mission is to provide the highest quality products and premium support that address the needs and demands of todayâ&#x20AC;&#x2122;s scientists and researchers. Visit us at www.peprotech.com for a complete list of PeproTechâ&#x20AC;&#x2122;s product line, references and more product details.

* All information in this pamphlet is current as of February 2013

PeproTech, Inc. Princeton Business Park 5 Crescent Avenue Rocky Hill, NJ 08553-0275 USA Tel: +1.800.436.9910, +1.609.497.0253 Email: info@peprotech.com

GMP  

PeproTech GMP products

Read more
Read more
Similar to
Popular now
Just for you