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Multifunctional and Biologically Active Matrices Inventors:

Serial Number: Filing Date:

Kiick, Kristi L.; Yamaguchi, Nori; Rabolt, John F.; Casper, Cheryl 60/833,994

Docket Number: UD06-29

July 28, 2006

This technology relates to a biologically active functionalized electrospun matrix to permit immobilization and long-term delivery of biologically active agents. In particular the invention relates to a functionalized polymer matrix comprising a matrix polymer, a compatibilizing polymer and a biomolecule or other small functioning molecule. In certain aspects the electrospun polymer fibers comprise at least one biologically active molecule functionalized with low molecular weight heparin. Examples of active molecules that may be used with the multi-component polymer of the invention include, for example, a drug, a biopolymer, a growth factor, a protein, a nucleotide, a polysaccharide, a biological macromolecule or the like. The invention is further directed to the formation of functionalized crosslinked matrices, such as hydrogels, that include as least one functionalized compatibilizing polymer capable of assembly.

Novel Hydrogels and Uses Thereof Inventors:

Serial Number: Filing Date:

Schneider, Joel; Pochan, Darrin J.; Rajagopal, Karthikan; Haines-Butterick, Lisa Provisional Filed

Docket Number: UD07-05

November 14, 2006

The present invention provides novel hydrogels and methods of making and using such hydrogels. The present invention provides hydrogels that may be formed by the self-assembly of peptides in solution; such self-assembly may be brought about by a change in one or more characteristics of the solution. Characteristics of the solution that may be changed include pH, ionic strength, temperature, and concentration of one or more specific ions. In addition, hydrogels of the invention may be disassembled by changing one or more characteristics of the hydrogel such as pH, ionic strength, temperature, and concentration of one or more specific ions.

Emulsification of Concentrated Dispersions of Colloidal and Nanoparticles Inventors:

Serial Number: Filing Date:

Wagner, Norman J.; Nam, Caroline H. 60/811,339

Docket Number: UD06-32

June 6, 2006

A novel method to emulsify dispersions into an immiscible or partially miscible carrier fluid is a new process that was inspired by the need to improve coating conditions of shear thickening fluids to ballistic grade fabrics such as Kevlar速. The methods entail the use of a co-solvent such as heptane to lower the viscosity of the particle dispersion and a surfactant dissolved in an immiscible carrier fluid, such as water. Different techniques can be used to achieve an emulsion: sonication and/or mechanical mixing.


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