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A community health education series from Stanford Hospital & Clinics

New Device, Hybrid Team Restore Ailing Heart Valves Once Inoperable

Three to four times a year, he’d see his long-time and trusted local cardiologist, but when he began to have difficulty breathing, he didn’t think it was very serious at first. “He told me my heart valve was getting progressively narrower and that at some point in time we’d have to start talking about doing something,” Verwer said. Perhaps a bit stubbornly, Verwer kept delaying that point in time. Months passed, and Verwer and his wife, Shon, traveled to Italy with his children and their families. “He really started to deteriorate,” Stockton said. “We all should have been walking and his fear was he wasn’t going to make it off the mountain.” Verwer limited his activities, to little avail. By February 2012, “he was going downhill daily,” his wife said. “He was doing nothing but sitting and sleeping. There was really something wrong.” She insisted he see his doctor, who put Verwer into the hospital for tests. His heart rate was fluttering that could be easily fixed,

but he was also suffering from aortic stenosis, the narrowing by calcium deposits of the body’s largest artery as it passes through the heart. Because of that narrowing, the blood flow through his heart’s main valve to his limbs and organs had been reduced to a fraction of what his body needed. His heart was working harder and harder, with less result. Without the oxygen carried by that blood, his ability to breathe and move, even to think, was seriously diminished.

“He was doing nothing but sitting and sleeping. There was really something wrong.” – Shon Verwer, wife of Gary Verwer, Stanford Hospital & Clinics patient Surgery was the standard fix, but Verwer would soon learn that his survival would be in the hands of a team of physicians at Stanford Hospital & Clinics entrusted with a brand-new technique for replacing narrowed aortic valves only recently approved by federal officials for use outside of clinical trials. His treatment, said Stanford cardiovascular surgeon Craig Miller, MD, would represent “a major medical paradigm shift something to address an otherwise fatal disease in patients whom we once could offer nothing but supportive care and counseling.”

Rising need for care

Norbert von der Groeben

Verwer represents a growing population of patients whose age brings serious health challenges. Aortic stenosis, the most common type of valvular disease, develops most often after age 60. At 76, Verwer is part of the bulging Baby Boomer demographic. Unfortunately, no medications have yet been found to be an effective treatment for the condition only valve replacement surgery can provide long term renewal of blood flow through this key point in the heart. But that surgery is among the Verwer represents a growing population of patients whose age has brought most traumatically inserious health challenges. Aortic stenosis, the most common type of valvular vasive to the body and disease, develops most often after age 60. considered high risk for

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Norbert von der Groeben

At 52, Gary Verwer paid for decades of indifference to his health with a triple cardiac bypass. A month later he was parasailing in Hawaii, enjoying a safe return to an active lifestyle that also included extensive business travel around the world. “It worked out great,” Verwer said. “I was able to do just about anything.” With a higher awareness of his heart health, he did pay closer attention to his diet. For more than 20 years, the repairs worked well, even as he aged and slowed down some. He made a happy new marriage and, with 10 grandchildren, spent more time than ever with them. Golf and gardening augmented his pleasures in life.

At 52, Gary Verwer paid for decades of indifference to his health with a triple cardiac bypass. For more than 20 years, the repairs worked well, even as he aged and slowed down some. But then his heart problems began again. older patients with other serious medical problems. Surgeons saw through the sternum, that flat bone in the middle of the chest. Then, as the old valve is removed and replaced by a prosthetic one, they transfer the heart’s pumping function to a heart-lung machine. Being on the heartlung machine carries risks of cognitive impairment. Moreover, physical recovery from such surgery can be weeks long. If a patient has other debilitating medical conditions, the risk for such surgery becomes prohibitive. A special barrier stood before Verwer: The bypass that had been so successful for so long had engaged another artery that, as part of the standard sternal route surgery, surgeons would have to cross to get to the aorta, and in that passage, might nick it. One surgeon refused. Another told him, “It would be really messy.” Then his cardiologist suggested Verwer call Miller and the heart valve team at Stanford. For four years, cardiovascular physicians there had been testing a new minimally invasive way to replace aortic valves. It was a technique specifically designed for those who, like Verwer, were not good candidates for the traditional surgical approach. Just weeks earlier, in November 2011, the FDA had acknowledged the success of the trials with such patients and approved Stanford as the first facility in the Bay Area to offer the device outside of a clinical trial. “Leave it up to the guys at Stanford,” Verwer’s cardiologist told him. “They’re very, very smart guys and they know what they’re doing.”

After the Verwers’ first conversation with Stanford’s Bill Fearon, MD, that was their feeling, too. Fearon, a cardiologist who specializes in non-surgical heart repair, “was so easy to talk to, very easy-going and open, we both walked out of there very confident that they could do what they said they could do and do it without a hiccup,” Verwer said.

New design, new pathway

Fearon was part of a team of Stanford physicians invited in 2008, along with others at specially selected medical centers, for a large-scale national test of a revolutionary new heart valve replacement and a method to implant it without major surgery. The Edwards SAPIEN transcatheter heart valve is made of bovine membrane attached to a stainless steel mesh frame with a polyester wrap. At one end of the valve, the edges float free except for three points of contact that create a tri-fold leaflet that mimics the human heart valvular flaps. The material and the design make it possible to compress the device into the narrow confines of the femoral artery, carried along through the body affixed to the end “I feel alive again,”Verwer said. “I fee of a tube, or life again. I’ll be dancing with my gr catheter. The

Palo Alto Weekly 08.17.2012 - Section 1  

Section 1 of the August 17, 2012 edition of the Palo Alto Weekly

Palo Alto Weekly 08.17.2012 - Section 1  

Section 1 of the August 17, 2012 edition of the Palo Alto Weekly