Ocutrx Vision Technologies, LLC (Non-confidential)

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Augmented Reality

for AMD, Low-vision, surgery visualization, and more


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Overview I. Augmented Reality vs Virtual Reality II. Oculenz AR for AMD III. EyeAlignz AR for Amblyopia IV. ORLenz AR for surgery visualization V. OR-Bot surgical visualization theatre VI. Additional applications VII. Team Ocutrx VIII. Ocutrx praise & press IX. Ocutrx financials & projections

Thank you for your time


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What is Virtual Reality? (VR)

Example of a VR headset:

•Replaces the real world •Shuts out the physical world •Completely immersive experience Ideal for: •Gaming •Military training Disadvantages: •Daily activities and walking around •Vertigo sensation

Click to read more

View while wearing a VR headset:


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What is Augmented Reality?

Ocutrx’s AR headset Oculenz: (AR)

•Enhances the real world •Digital elements overlay real world surroundings Ideal for: • Complete user freedom • High/low light surroundings • Low vision, medicine, military, drones, HAZMAT, education, retail and more Disadvantages: • Not ideal for completely immersive experiences (if not using Dynamic Opacity) Click to read more

View through AR headset:


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Oculenz™ For A d v anc e d

Mac u l ar D e g e n e rat i on

Additional Applications OCULENZ

AR for Advanced Macular Degeneration (AMD)


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What is AMD? (Age-Related Macular D e g e n e ra t i o n ) •Most common cause of vision loss in older adults NORMAL

EARLY

•Cause patients to see a blind spot (scotoma) in their central vision •Scotoma caused by damage to the macula

INTERMEDIATE

ADVANCED

Click to read more


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Wha t a n A MD pa t ie n t s ees


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Who has AMD? 50

TOTAL MARKET

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20

TOTAL MARKET

13M US*

30M WORLDWIDE **

22M US*

288M WORLDWIDE **

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SERVICEABLE US MARKET SERVICEABLE US MARKET

17M

10M

ADDRESSABLE US MARKET***

1M

* National Federation of the Blind – 2018 ** Bright Focus Foundation – 2016 ***With the assumption that market penetration is only 10%

ADDRESSABLE US MARKET***

1.7M

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Patient #1 Richard Freeman • Father of Ocutrx founders • Brigadier General in the Air Force, inventor, entrepreneur • Diagnosed with AMD; no central vision • Using the Oculenz headset, could read and recognize the faces of his family for the first time in years


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Current AMD Competition •VR not AR •Heavy or tethered •Indoor use only •No peripheral vision •Cannot walk with device •None move images outside of the patient’s blind spot


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Competitive advantages o f O c u t r x ’s O c u l e n z

Lightest Weight 250 grams (less than a cell phone)

Highest Resolution 60 pixels per degree (highest the eye can see)

Widest Field of View 120 degrees

Patented Eye-tracking technology

Dynamic Opacity AR to VR instantly

Class 1 Device No FDA approval needed

WiDtrx wireless zero latency 4K internet

Artificial Intelligence & Machine Learning, voice command & control

SLAM Simultaneous Localization and Mapping software for instant location mapping & object identification with 7 million objects recognized


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How I sdoes i t e f f e cit t i v ework? ?


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Step 1: Visual F i e l d Te s t

• Patients put on the headset and take a visual field test • Patients see concentric circles and streaks of light • We map the areas they cannot see with a Scotoma Marker

Scotoma Marker


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Optic Nerve Dark area: Patient’s scotoma (blind spot)

Fu n d u s A u t o f l u o r e s c e n c e p h o t o with overlaid Ocutrx Scotoma Marker Red Dots: Test areas where patients cannot see Green Dots: Test areas where patients can see Key takeaway: Our unique scotoma marker software matches patient’s scotoma (blind spot) per eye

Green Circle: Scotoma Marker


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4K cameras

Scotoma Marker saved in processing unit

Step 2: Pa t e n t e d Pixel Mapping

Dynamic Opacity Lens

Battery Micro-displays

• • • •

Scotoma Marker data is stored in processing unit Video from 4K cameras taken from real world Patented technology moves images outside of scotoma Micro-displays project hybrid image onto lens


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Step 3:

Infrared Lights

Pa t e n t e d E y e -Tr a c k i n g Eye-tracking cameras

•Infrared lights illuminate eye gaze, allowing eye-tracking cameras to follow eye movement •Eye-tracking keeps scotoma marker in line with augmented image on lens


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Step 4: Revolutionary In-Home Pa t i e n t Monitoring

• • • •

Oculenz sends visual field test results to physicians via HIPAA-secured cloud Alerts physician if scotoma changes, indicating possible disease progression Allows in-home monitoring of patient’s disease Can reduce unnecessary visits to physician’s office


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Before Oculenz:

After Oculenz:

Step 5: Image is moved around blind spot to areas of healthy retina


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Is it I s i teffective? effective?


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Click t o wa t ch a video f rom ou r recen t pa t ien t t ria l

*Patient in this trial wore our previous prototype without magnification


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Ou r s u cce s s f u l recen t pa t i e n t s t r i a l s how e d • Best-corrected visual acuity improved from 20/200 to 20/63; from being legally blind to being able to read • Patients could read 4-5 lines more on eyechart • For comparison: cataract surgeries are considered a success if patient can see 2 lines more on eyechart • Zero patients in the trial could read without Oculenz; all patients were able to read 30-point type; some patients were able to read 12-point type • Patients were able to discern faces that were previously unrecognizable prior to Oculenz

This is 30–point type This is 12-point type

Click to watch a patient’s experience with Oculenz


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H ow is Ocu t rx’s O c u l e nz revolu t ion a ry? VISUAL FIELD TESTING

Other visual field test systems cost up to $25,000 and require 20 minutes per eye Oculenz is significantly less costly Our in-home test requires 5 minutes per eye

PI XE L-MAPPI N G AROUND BLIND-SPOT

IN-HOME MONITORING

All other visual aids only magnify the image and do not move the image onto healthy retina

Oculenz alerts doctors when the blind spot (scotoma) changes, allowing for in-home monitoring of disease

AMD patients who have used Oculenz said it improved their quality of life significantly

Reduces unnecessary doctor visits and increases essential visits that might have otherwise been missed


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EyAlignz™ For Amblyopia (Lazy Eye)


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Who has Amblyopia?

• Leading cause of monocular vision loss in children and young adults • Leading cause of blindness in one eye • 200,000+ additional patients each year • Treatable for children & adults

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TOTAL MARKET

9M US

122M WORLDWIDE

SERVICEABLE US MARKET

7M

ADDRESSABLE US MARKET

1M

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Cu rren t Am blyopia Trea t m en t

• Current bandage patching is less effective due to non-compliance; children are not wearing patches • Current bandage patching does not offer binocular integration, which is essential for correcting lazy eye • VR therapy does not allow patients to walk while wearing device


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H ow d oes EyA lig n z work ? • AR headset electronically occludes dominant eye • Patches dominant eye which forces nondominate (lazy eye) to follow AR icons/images • Tracks eye gaze through patented eyetracking technology and monitor patient’s progress • As lazy eye improves, device gradually reduces dominant eye patching • This promotes binocular integration


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H ow is Ocu t rx’s E y A l ig nz revolu t ion a ry? G A M I F I C AT I O N

IN-HOME MONITORING

Gamifies therapy as children use eye-tracking technology to chase dragons and dance with princesses

In-home monitoring allows for daily tracking of eye alignment therapy, without needing to visit doctor’s office

Increase compliance by prescribing fun, customized treatment tailored to each patient’s preference

Doctors can remotely personalize therapy based on data received

DY N A M I C O PA C I T Y

Promote lazy & dominant eye to work binocularly by gradually changing the lens’ shading EyAlignz therapy is customized and will enable faster vision rehabilitation


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™ OR-Bot and ORLenz™

The surgery system of the future.


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What’s the problem with current surgery I s i t e f f e c t i v esystems? ?


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Better Ergonomics

51%

Surgeons who experience neck, back, body, or musculoskeletal pain

15%

Surgeons who reduce number of surgeries they perform due to pain

7%

Surgeons who retire from surgery due to pain

“Surgeon positioning should be a high priority in the OR. The ergonomics team identifies ergonomic risk factors when assessing general work tasks, including awkward postures and prolonged duration of tasks performed. The General Surgery residents are in surgery between 5 and 8 hours, so we make recommendations that will address those risk factors.” -- Marissa Penitco Department of Surgery Ergonomics Corordinator; Duke Ergonomics Division, Duke University


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Pro b l e m s w i t h c u r re n t s u rg e r y systems… Ergonomics

• Current surgery systems force surgeons to strain back, neck, and arms during operations

Space Constrains

• Current surgery systems require SOM and digital camera to be directly over the patient, which limit surgeon’s agility

Poor Resolution

• Current surgery systems have limited resolution at 1080P • Current surgery systems do not have true 4K resolution • 3D glasses block 50% of light and obscure surgeon’s vision


Problems with 3D glasses • 3D glasses dramatically block surgeon’s view • Current headsup surgery systems require surgeons to wear polarized 3D glasses to view the television monitor • 3D glasses block 50% of light • 4K television only projects half or less of the 4K resolution to each eye, meaning the resolution s surgeon sees is not true 4K and is only 1080p


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What’s I s i the t e f f e csolution? tive?


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OR-Bot Surgery Visualization Theatre


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Dr. Bill Link, PhD says… “The new OR-Bot will offer surgeons several comfortable, lightweight, and ergonomically sound solutions to better perform delicate ophthalmic procedures with faster-surgery setup and turn around.”

Dr. Link is a KOL in the medical industry, is principal of Flying L Partners, and is currently the Chair of our International Scientific Advisory Board


The Surgery Suite of the Future 36

OR-Bot™ Surgery Visualization Theatre • AR Microscope gives true 4K resolution • 8K Autostereoscopic Monitor shows 3D without 3D glasses • 6-Axis Cobotic Arms offers advanced surgical ergonomics • Separating camera and microscope eliminates space constraints

ORLenz ™ Surgery Visualization AR Headset • State-of-the-art surgery visualization • Surgeon maintains comfortable posture • Surgeon can change position while 3D hologram image stays locked in place • Receives 4K feed from surgery camera with <10ms delay


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OR-Bot™ Advantages Separating camera from SOM reduces space constraints

WiDtrx Wireless Internet transmits video feed as fast as wired internet without being tethered

6-Axis Cobotic Arms gravity compensated + voice & touch activated

S u r g e o n ’s h a v e r e q u e s t e d three viewing options ORLenz™ AR Headset portrays surgical video feed in true 4K resolution per eye + 3D holograph rendering with 6DoF StereoLenz™ 8K 3Dtrx “glasses free” Monitor reduces viewing limitations by eliminating the need for 3D glasses MiniLenz™ VR Microscope gives true 4K resolution per eye

1.

2.

3.


StereoLenz™ 3Dtrx Digital 8K Monitor Problem with current surgery systems: • Surgeon must wear 3D glasses to view monitor which blocks light • Monitors have low resolution OR-Bot solutions: • Unique 3Dtrx monitor allows surgeons, nurses, techs, and students to view surgery from anywhere in the OR without 3D glasses • True 4K resolution per eye without 3D glasses


OR-Bot 6-axis, automatic, gravity compensated arms MiniLenz™ 3D 4K VR Microscope Viewer

Oc

utr x

Zeiss

OR-Bot 4K high depthof-field cameras

MiniLenz™ 3D VR Microscope viewing Problems with current surgery systems: • Surgeon must cramp over SOM • Ergonomic challenges from leaning over microscope configuration • Space constraints of combined camera and microscope in operating area MiniLenz™ solutions: • 3D 4K viewing each eye • SLAMtrx technology automatically brings MiniLenz to surgeon’s eyes • MiniLenz minics surgeon’s head movements and keeps eyes in line with viewing • Improve surgeon ergonomics by bringing tools to the surgeon with automatic, gravitycompensated, 6 axis cobotic arms • Only a slight touch needed to move arms • Using hand gesturing or voice commands sensors brings microscope and camera to surgeon


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WiDtrx™ No Latency Wireless Internet

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1. OR-Bot surgery camera 2. WiDtrx “wireless internet” 3. ORLenz AR headset

Problem with current surgery systems: • Current surgery headsets must be wired (HDMI) to receive video feed from camera WiDtrx solution: • WiDtrx wireless internet is as fast as HDMI connection but is wireless • WiDtrx sends 4K video feed to ORLenz AR headset with no lag time (less than 10 milliseconds) WiDtrx for telemedicine: • A surgeon in California and a surgeon in Africa will view the same digital information • Enable telemedicine and encourage teaching across borders


6-Axis Cobotic Arms • Robotic + human guided arms • Gravity-compensated • Responds to both the touch of an assistant and internal power & can be moved using slight touch • Sensor in the microscope brings the tool automatically to the surgeon’s eyes with hand gesturing or voice command.


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ORLenz™

A u g m e nt e d R e al it y for s u rg e r y V is u al izat ion


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Finley Headset video


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Surgery Headset Competition •Uses Waveguide technology •Blocks too much ambient light

Magic Leap

Hololens 2

•Too heavy •Limited field-of-view •Low resolution Beyeonics

3D Glasses


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More about the competition Magic Leap • • • •

Blocks 85% of ambient light Waveguide technology Magic Leap is for sale Has laid off half their staff

Hololens 2 • • • •

Blocks 60% of ambient light Waveguide technology Users report “laser nightmares” Has shut down production line due to chromatic aberration


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The problem with Waveguide technology • Waveguide works by transmitting images via fiberoptic cables from back of headset to front of lens • Fiberoptic cables can pinch, causing dispersion of colors called chromatic aberration (see image on right) • All competitors use Waveguide technology


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Competitive advantages of the ORLenz

Lightest Weight 250 grams (less than a cell phone)

Highest Resolution 4K to each eye 60 pixels per degree (highest the eye can see)

Widest Field of View 120 degrees

Patented Eye-tracking technology

Dynamic Opacity AR to VR instantly

Hot-Swap battery allows battery to be changed during surgery

WiDtrx wireless zero latency 4K internet

Artificial Intelligence & Machine Learning, voice command & control

6DoF Six degrees of freedom image poising, hand and head gesturing control with virtual menus of patient vials


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ORLenz set to improve all surgery experiences

• • • • • • •

Neurosurgeons Surgical oncologists Orthopedic surgeons Ophthalmology surgeons Cardiac surgeons Interventional radiologists And more

Headset types:

• Surgeons • Surgical techs • Students


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ORLenz has widest field- of- view

Hololens 1 34° FOV per eye Magic Leap 40° FOV per eye Hololens 2 43° FOV per eye Ocutrx ORLenz™ 60° FOV per eye


Dynamic Opacity™ Changes from AR to VR instantly

• Lens can be up to 85% see-through, even in bright light conditions and outside (Other AR headsets block up to 85% percent of light in order to see AR image) • During surgery, lens safely blocks harmful laser lights and wavelengths • Outer lens contains revolutionary cholesteric liquid crystals which create a shadow; shadow mirrors image being projected onto screen • Lens transition from low to high light and then are bi-stable, in this state the power remains stable (Other AR headsets need constant power)


Ocutrx’s AI engine Neural Datrx™ •

Ocutrx’s AI engine Neural Datrx will analyze data from thousands of surgeries to reduce surgical risks and improve patient safety

ORLenz shows a virtual marker where the surgeon should best position tools based on AI data statistics

Optimize surgical results and patient outcomes ”MR. AI” Dr. Daniel Ting


Current surgery systems force the IR to physically touch equipment.

The ORLenz will allow IR to virtually touch equipment.

ORLenz for Interventional Radiologists Problem with current surgery systems: • Interventional Radiologists have to touch a computer to change a view or screen, which means they must re-sterilize each time ORLenz solutions: • Interventional Radiologists will be able to use virtual “touch” (through hand and finger gesturing) • All menus will transition into virtual menus


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Additional Applications


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Augmented Reality for telemedicine

• Real-time video chat with a physician • Video above 4K resolution • HIPAA-secured transmission of patient vitals: • respiratory effort • respiratory rate • visual field tests • blood pressure • pulse oximeter • eye-tracking • temperature • heart rate • weight • EKG • OCT 2020 First Families COVID Response Act mandates Medicare reimbursement.


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Augmented Reality for collecting clinical trial data •Pharmaceutical startups will administer drugs for clinical trials virtually •Reducing time needed for FDA clearance •Reducing cost of clinical trials


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Augmented Reality for enterprise

• Industrial use • Oil and gas • Gaming • Military • Drones • Enterprise

*AR headset is flipped up into helmet


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INDUSTRAL USE

• Production line improvement • Monitoring for employee fatigue and drug use • Replaces laptop by superimposing virtual guides on top of assembly field • SLAM technology allows digital space mapping in hazmat or fire situations to highlight exits for evacuation

OIL AND GAS

• Field service personnel in remote locations collaborate with off-site experts • Aids in predictive maintenance by visually showing the current status of machinery • Remote service capabilities allows experts to diagnose issues remotely


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GAMING

• Ocutrx’s open platform allows gamers to develop their own apps and games to be played on the Oculenz headset • Can be played in high-light settings due to Dynamic Opacity • Gaming will be a $230 billion market in 2022, and Ocutrx will add to this growth projection

MILITARY & DRONES

• Eye gesturing displays controls, such as altitude, speed, battery, relative map • Synthetic training environment • Battlefield augmented reality system • Battlefield event recreation • Incorporation of drone information directly on lens display


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Team I s i t e f fOcutrx ective?


Award Winning Founders + Management Team 60

Linda Lam Jordan Boss Simon Prosser MD MBA Chief Product Engineer Global Director of Chief Scientific and Surgical Applications Strategy Officer

Michael Freeman JD CEO

Mitchael Freeman COO

The Freeman brothers are the inventors of mobile video, have over 60 patents, and were awarded two Emmy Awards in the 1990s for their innovation. The Freemans sold streaming mobile video to Samsung in the 2000’s and became the foundation for IEEE 802.11(n) MIMO standards. Today this technology is used when you send videos and use 4G. Ocutrx was founded by Michael and Mitch Freeman in 2015 to help their father with Macular Degeneration.

John Bluher JD,CPA Director of Finance

Kevin Griffin CPA Chief Financial Officer

Michaela Stites Chief Administrative Officer

Steven Yeager Chief Hardware Officer

Victoria McArtor MFA Chief Communications Officer

Montgomery Freeman Chief Marketing Officer


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Ke y O p i n i o n L e a d e r s

Thomas Finley MD Tulsa Retina Consultants

Bill Link PhD Ophthalmology KOI

Linda Lam MD MBA Keck School of Medicine USC

Richard Lindstrom MD Minnesota Eye Clinic

International Medical Advisory Board

Cuong D. Vu MD Retina Group of Washington

Hugo Mercado MD APEC Mexico City

Sam Garg MD UC Irvine

Lars Freisberg MD Tulsa Retina Consultants

Pat Yoshinaga OD Daniel Ting MD, PhD SoCal School of Singapore National Optometry Eye Center

Michael Albert MD University of Alabama

Diane Whitaker OD Duke University


International Scientific Advisory Board 62

Dr. Bill Link PhD

• Several decades of operations experience in healthcare industry • Record of building & managing large, successful medical product companies • Founded companies which still today are leaders in surgical ophthalmology field

Dr. Linda Lam MD MBA

• Vice Chair at USC Eye Institute, Keck School of Medicine • Aids in strategic planning and business development • Extensive experience speaking on macular degeneration, vision rehab, surgery, and technology

Dr. David Kessler

Dr. Daniel Ting

Tom Radebaugh, BSEE

• Holds 93 US patents • Authored 24 publications • During 24 years at Kodak Research Lab, founded and managed optical systems design group • Currently developing new optical systems microscopic designs

• Asst Professor at DukeNUS Medical School Singapore • Retinal Consultant at the Singapore National Eye Center • Published more than 90 peer-reviewed papers and educational articles, including more than 20 on AI

• Founder & Program Director for Spectrum AMT • Leading global expert in PCB design & development • Expertise includes Engineering, Patent development, & FDA 510K product/process expertise

PhD

MD, PhD


Regulatory Consultants 63

Dr. Ronald Schuchard PhD

• Fellow of ARVO, Assoc. for Research in Vision and Ophthalmology • Executive Director of the Envision Research Institute • Former FDA developer and evaluator • Lead reviewer of FDA vision medical device submissions

Dr. Frederick Ferris MD

• Fellow of AAO, American Academy of Ophthalmology • Clinical director and medical retina specialist at NEI, National Eye Institute • Extensive experience in designing and managing multicenter clinical trials

Hogan Lovells • Regulatory pathway plan being developed by Hogan Lovells, world-renowned law firm • Seeking FDA and European Medicines Agency approval in US, UK, and EU


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Intellectual Property Aggressive patent program to ensure value for our company and investors

4 issued patents

69 pending patents Additional patents for ORlenz and OR-Bot have been filed and are pending

90+ expected total patents

Other patents will be filed on AR features such as micro-displays, applications, connectivity, and more


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Pa r t n e r s h i p s ATT: data connection & cellular plans QUALCOMM: XR-2 chipset SPECTRUM AMT: testing and manufacturing KARTEN DESIGNS: AR headset design SONY: camera & micro-display vendor PRIMO Microphones: vendor & assembler (Also the assembler for BOSE.) HOGAN LOVELLS: FDA & regulatory counsel STRADLING Law Firm: Corporate counsel


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What industry leaders s i t e f f e cabout t i v e ? us are I saying


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Analysts are praising Ocutrx

“The company has done a great job on focusing on specific case need. Really cool technology. Looks to have solid positioning.” -Lewis Ward, IDC, the premier global market intelligence firm.

“Wow. The potential here is unending.” -Ryan Zimmerman, BTIG Research and Strategy

“Ocutrx is creating an exciting technology-based solution that can offer hope to individuals with severe and disabling vision defects….” -Victor Camlek, Frost & Sullivan


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Te c h a n d M e d p r e s s authors praise Ocutrx

Click Click

Ocutrx seems to be something that advanced hospitals interested in AR may wish to investigate” -Forbes “The demand for this technology is going to be very significant over the next ten years” -OC StartUps Now “Oculenz AR glasses can restore independence and quality of life to individuals with AMD or low vision” -Modern Optometry

Click

Click Strongly encouraged to watch 2-minute interview.


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Ocutrx technology receives recognition 2018 Top 15 Most Promising Wearable Technology Startups

Click to read more

2019 Top 15 Most Promising Wearable Technology Startups Top 15 Most Promising IOT Startups

2020 Top 15 Most Promising Wearable Technology Startups


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H o t o ff t h e p r e s s

118

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24.7M

Online readership


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THANK YOU Certain statements that Ocutrx Vision Technologies, LLC. (the “Company”) has included in this presentation may constitute "forward-looking statements" and are subject to a number of significant risks, uncertainties and estimations. Any such forward-looking statements contained herein should not be relied upon as predictions of future events. Certain such forward-looking statements can be identified by the use of forward-looking terminology such as "believes," "expects," “can,” "may," "will," "should," "approximately," "intends," "plans," "estimates," or "anticipates" or the negative thereof or other variations thereof or comparable terminology, or by discussions of strategy, plans or intentions. Such forward-looking statements are subject to numerous risks and are necessarily dependent on assumptions, data or methods that may be incorrect or imprecise and may not be realized. Thus, the matters discussed below and elsewhere could cause actual results, returns and other matters to differ materially from those in such forward-looking statements. As a result of the foregoing, no assurances can be or are given as to future results of operations or financial condition of the Company or its Subsidiaries. This presentation is only available to persons and/or entities who are Accredited and Qualified Investors, and who execute a Confidentiality and NonDisclosure Agreement, and otherwise meet criteria applicable for investments which are exempt from registration under the Securities Act of 1933, including, but not limited to Section 4(2) and Rule 504, 505, 506 and other provisions of the Act and under applicable state and local securities laws, and as are otherwise qualified by the Company to review these materials. Further, additional information, interviews, and a review of the Company’s Private Placement Memorandum is required before making any investment decision. Other appropriate information may be reasonably requested from representatives, advisors, attorneys and/or accountants of the Company. Except as otherwise stated herein, all rights and copyrights to the materials, analysis, projects and plans are reserved and claimed by the Company. No portion of these materials may be copied, or disclosed to anyone other than the recipient nor reproduced without the express written permission of Ocutrx Vision Technologies, LLC.