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THE NEW YORK STEM CELL FOUNDATION INVESTIGATOR PROGRAM Scientists leading their generation in cutting-edge research


Cover: Kristen Brennand, PhD, 2013 NYSCF – Robertson Stem Cell Investigator Image by: Veronica Szarejko


The New York Stem Cell Foundation is accelerating cures for the major diseases of our time through stem cell research.


N Y S C F I N N O V AT O R C O M M U N I T Y A global community of over 150 scientists leading their generation in cutting-edge research

The NYSCF Research Institute Laboratories conduct the most advanced human stem cell research and develop pioneering technologies for the field. Independent and privately funded, NYSCF takes a “team science” approach to advance cures, collaborating with leading global partners to unravel the root causes of disease through the power of stem cells.

The NYSCF Fellowship Program supports postdoctoral scientists at an early stage of their careers.These young researchers hold the potential to accelerate treatments and cures. The Program provides support for: • NYSCF – Druckenmiller Fellows

The NYSCF Investigator Program supports early career scientists, creating and promoting a global community of leading stem cell and neuroscience researchers. The Program provides support for: • NYSCF – Robertson Stem Cell Investigators • NYSCF – Robertson Neuroscience Investigators • NYSCF – Robertson Stem Cell Prize Recipients


NYSCF I N V E S T I G ATO R PROGRAMS The NYSCF Investigator Programs support and encourage promising early career scientists whose cutting-edge research holds the potential to accelerate treatments and cures. The Programs provide critical seed funding to these outstanding scientists, supporting them as they move beyond their postdoctoral training to establish their own, independent research. The Programs provide support for: • NYSCF – Robertson Stem Cell Investigator Awards • NYSCF – Robertson Neuroscience Investigator Awards • NYSCF – Robertson Stem Cell Prize • NYSCF Research Institute Investigators


N Y S C F – R O B E RT S O N STEM CELL INVESTIGATOR AWA R D S The NYSCF – Robertson Stem Cell Investigator Awards provide five years of critical seed funding to outstanding early career scientists all over the world. The Program fosters bold and innovative scientists with the potential to transform the field of stem cell research, and advance the understanding and use of stem cells in the development of treatments for human disease.


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SERGIU PASCA, MD Stanford University Dr. Pasca is an Assistant Professor of Psychiatry and Behavioral Sciences at Stanford University and Director of the Stanford Neurosciences Institute Stem Cell Core. He is primarily focused on the development of new approaches for studying human brain development, like building mini brain organoids, and for uncovering the mechanisms of neuropsychiatric disorders. He completed his postdoctoral studies at Stanford University.

LOUIS VERMEULEN, MD, PHD Academic Medical Center, Amsterdam, The Netherlands Dr. Vermeulen is a Principal Investigator at the Center for Experimental Molecular Medicine at Academic Medical Center, Amsterdam, The Netherlands, where he is focusing on the role of stem cells in colorectal cancer development and progression. He aims to develop improved preventive strategies and novel, more effective therapies for this disease by studying the effects of genetic mutations on the behavior of stem cells in the gut. He completed his postdoctoral studies at University of Cambridge, United Kingdom.

BRIAN WAINGER, MD, PHD Massachusetts General Hospital Dr. Wainger is an Assistant Professor of Neurology and Anesthesia at Massachusetts General Hospital. His lab aims to develop a precision medicine platform by which analyses of stem cells and derived cell types can be used to build more powerful human models in the laboratory. He is also currently conducting clinical trials in patients with amyotrophic lateral sclerosis (ALS). He completed his residency and clinical fellowship at Massachusetts General Hospital and Brigham & Women’s Hospital.


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MARIA BARNA, PHD Stanford University Dr. Barna is an Assistant Professor in the Departments of Developmental Biology and Genetics at Stanford University. Her lab focuses on the importance of ribosomes in cell communication to determine stem cell development and gene expression. She aims to show how ribosomes are involved in the remarkable diversity of cell types characteristic of normal embryonic development. She completed her postdoctoral studies at University of California, San Francisco.

MALIN PARMAR, PHD Lund University, Sweden Dr. Parmar is a Professor in the Cellular Neuroscience Department at Lund University, Sweden, where she is focusing on bringing new cell-based therapies for Parkinson’s disease to the clinic by replacing lost dopamine neurons with new, healthy cells. Her work in cellular reprogramming opens up the possibilities of personalized treatments of patients with healthy versions of their own cells. She completed her postdoctoral studies at Lund University, Sweden and Edinburgh University, Scotland.

TAKANORI TAKEBE, MD Cincinnati Children’s Hospital Medical Center Dr. Takebe is an Assistant Professor in the Division of Gastroenterology, Hepatology and Nutrition and Division of Developmental Biology at the Cincinnati Children’s Hospital Medical Center and Associate Professor at Yokohama City University, Japan. His lab is developing and applying mini-organ technologies from human stem cells – namely organ bud transplants – in patients with a rare congenital metabolic disorder, ultimately expanding the clinical applications to diseases like liver cirrhosis. He completed his postdoctoral studies at Yokohama City University, Japan.


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MITCHELL GUTTMAN, PHD California Institute of Technology Dr. Guttman is an Assistant Professor in the Division of Biology and Biological Engineering at the California Institute of Technology. His lab aims to understand how lncRNAs, a class of noncoding genes described by Dr. Guttman, perform many jobs in the cell, among them regulating the plasticity of embryonic stem cells and controlling how stem cells become any other kind of cell. He completed his postdoctoral studies at MIT and the Broad Institute of MIT and Harvard.

JUSTIN ICHIDA, PHD University of Southern California Dr. Ichida is an Assistant Professor in the Department of Stem Cell Biology and Regenerative Medicine at the University of Southern California, where he is focusing on using patient-specific disease modeling, next-generation sequencing, and chemical screening to identify disease mechanisms and new treatments for Lou Gehrig’s Disease and sensorineural hearing loss. He completed his postdoctoral studies at Harvard University.

KRISTY RED-HORSE, PHD Stanford University Dr. Red-Horse is an Assistant Professor in the Biology Department at Stanford University, where her lab focuses on how cardiovascular stem cells behave in three dimensions and at the single cell level, bringing a high-resolution understanding of embryonic development to injury and disease models. She completed her postdoctoral studies at Genentech and Stanford University.


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VALENTINA GRECO, PHD Yale University Dr. Greco is an Associate Professor at Yale University where she is utilizing genetic, live imaging and genomic approaches to capture the emergence of cancer by live imaging to transform current therapeutic strategies to cure and prevent cancer. She received her PhD from European Molecular Biology Laboratory, and completed her postdoctoral training at The Rockefeller University.

JENNIFER E. PHILLIPS-CREMINS, PHD University of Pennsylvania Dr. Phillips-Cremins is an Assistant Professor at the University of Pennsylvania where her lab focuses on understanding the mechanisms that govern producing healthy neurons from stem cells and how these mechanisms go awry during the onset of neurodegenerative diseases. She received her PhD from Georgia Institute of Technology, and completed her postdoctoral training at Emory University and UMass Medical School.

FENG ZHANG, PHD Broad Institute of MIT and Harvard Massachusetts Institute of Technology  r. Zhang is a Core Member of the Broad Institute and the W. M. Keck D Career Development Professor of Biomedical Engineering at MIT where he is developing and applying disruptive technologies including optogenetics and genome engineering (TALEs and CRISPR) to understand nervous system function and disease. He received his PhD from Stanford University and completed his postdoctoral training at Harvard.


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KRISTEN BRENNAND, PHD Icahn School of Medicine at Mount Sinai Dr. Brennand is an Associate Professor of Psychiatry at the Icahn School of Medicine at Mount Sinai where her research focuses on schizophrenia, a debilitating psychiatric disorder with no cure. She completed her postdoctoral research at the Salk Institute for Biological Studies.

JACOB HANNA, MD, PHD Weizmann Institute of Science, Israel Dr. Hanna is a Senior Scientist in the Department of Molecular Genetics at the Weizmann Institute of Science in Israel, where he explores topics in embryonic stem cell biology, early embryonic development and the modeling of human diseases. His research holds the promise of creating powerful research models for degenerative and autoimmune diseases such as type 1 diabetes. He completed his postdoctoral studies at the Whitehead Institute for Biomedical Research at MIT.

JAY RAJAGOPAL, MD Harvard Medical School Dr. Rajagopal is an Associate Professor at Harvard Medical School and the Center for Regenerative Medicine at the Massachusetts General Hospital, where his laboratory focuses on the application of stem cells and regenerative biology to human lung disease. He completed his postdoctoral research at Harvard University.


N Y S C F – R O B E RT S O N NEUROSCIENCE INVESTIGATOR AWARDS The NYSCF – Robertson Neuroscience Investigator Awards provide five years of critical seed funding to outstanding early career scientists all over the world. The Program supports truly innovative neuroscientists whose research holds the potential to transform our fundamental understanding of the brain and how it functions.


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STEPHEN BROHAWN, PHD University of California, Berkeley Dr. Brohawn is an Assistant Professor in the Department of Molecular & Cellular Biology at University of California, Berkeley. His lab is focused on understanding how the nervous system senses and responds to physical forces, which is at the heart of the classic senses of hearing and touch. It also underlies other sensations, including those involved in balance, pain, breathing, digestion, and blood pressure control. He completed his postdoctoral studies at The Rockefeller University.

GREGORY SCHERRER, PHD, PHARMD Stanford University School of Medicine Dr. Scherrer is an Assistant Professor in the Departments of Anesthesiology and Neurosurgery at Stanford University School of Medicine, where he is proposing to alter the brain’s interpretation of pain signals to eliminate the unpleasantness associated with pain and restore patients’ quality of life. Long term, he hopes to discover new drugs that can interfere with the function of neurons to ultimately provide pain relief and provide a therapeutic solution for millions of patients. He completed his postdoctoral studies at Columbia University.

ILANA WITTEN, PHD Princeton University Dr. Witten is an Assistant Professor in the Neuroscience Institute and Department of Psychology at Princeton University. Her lab studies the neural circuits for reward learning and decision-making, with a focus on the role of dynamics and feedback in these cognitive processes. The work promises to provide important insights regarding how actions are linked to later occurring outcomes in support of learning, a central open question in the field of reinforcement learning. She completed her postdoctoral studies at Stanford University.


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MARIA LEHTINEN, PHD Boston Children’s Hospital Dr. Lehtinen is an Assistant Professor in the Department of Pathology at Boston Children’s Hospital, Harvard Medical School. Her research focuses on how cerebrospinal fluid regulates the development and health of the brain. By determining the mechanisms by which the cerebrospinal fluid delivers instructive cues for stem cells in the brain, her lab can provide the foundation for understanding normal brain development. She completed her postdoctoral studies at University of Helsinki, Finland and Boston Children’s Hospital.

CLAIRE WYART, PHD Brain & Spine Institute (ICM), France Dr. Wyart is an Independent Group Leader at the Brain & Spine Institute (ICM), France, where her team focuses on the presence of multiple signaling molecules in the cerebrospinal fluid that regulate complex behavior, such as appetite, locomotion, sleep and arousal, and sickness behavior. Her work aims to understand how the central nervous system can perceive and respond to internal state changes in both body and brain. She completed her postdoctoral studies at University of California, Berkeley and the Curie Institute, France.

MICHAEL YARTSEV, PHD University of California, Berkeley Dr. Yartsev is an Assistant Professor in the Department of Bioengineering and the Helen Wills Neuroscience Institute at University of California, Berkeley. His lab uses neurophysiological, optogenetic, imaging and molecular techniques in a novel model system – the bat – to study the neurobiological basis of language learning in the mammalian brain and ultimately investigate a wide range of neurological disorders associated with language. He completed his postdoctoral studies at Princeton University.


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HILLEL ADESNIK, PHD University of California, Berkeley Dr. Adesnik is an Assistant Professor of Neurobiology at University of California, Berkeley, where he is focusing on revealing the neural basis of sensory perception at the synaptic, systems, and behavioral levels. He completed his postdoctoral studies at University of California, San Diego.

DRAGANA ROGULJA, PHD Harvard Medical School Dr. Rogulja is an Assistant Professor in the Department of Neurobiology at Harvard Medical School, where her lab is focusing on the genetics of sleep regulation and the molecular regulatory mechanisms and neuronal circuitry of the sensory gating that takes place in the various stages of sleep. She completed her postdoctoral studies at The Rockefeller University.


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EDWARD CHANG, MD University of California, San Francisco Dr. Chang is a neurosurgeon, Chief of Epilepsy and Pain Neurosurgery and a Professor at the University of California, San Francisco, where he specializes in advanced clinical brain mapping methods, including awake speech mapping, to safely perform neurosurgical procedures in eloquent areas of the brain. He received his medical degree from UCSF, and completed his postdoctoral training at UC Berkeley.

LISA GIOCOMO, PHD Stanford University School of Medicine Dr. Giocomo is an Assistant Professor at Stanford University, where her lab integrates a variety of disciplines and tools to study how singlecell biophysics and network dynamics interact to mediate spatial memory and navigation. She received her PhD at Boston University, and completed her postdoctoral studies at The Norwegian University of Science and Technology.

KAY M. TYE, PHD Massachusetts Institute of Technology  r. Tye is an Assistant Professor at Massachusetts Institute of Technology D where her lab focuses on understanding how the brain processes the differences between positive and negative stimuli, and leveraging cutting-edge techniques to reprogram neural circuits to induce long lasting changes in behavior. She completed her postdoctoral training at Stanford University.


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WINRICH FREIWALD, PHD The Rockefeller University Dr. Freiwald is an Associate Professor at The Rockefeller University where he heads the Laboratory of Neural Systems. His work focuses on the neural circuit mechanisms of face recognition, attention, and social cognition. He completed his postdoctoral training at MIT and Harvard Medical School.

DANIEL HUBER, PHD University of Geneva, Switzerland Dr. Huber is an Assistant Professor in the Department of Basic Neurosciences at the University of Geneva, Swizerland, where his lab currently combines novel behavioral paradigms with electrophysiology and innovative optical imaging tools to study how different areas of the frontal cortex interact during decision-making and the control of goal-directed action. He completed his postdoctoral studies at the Cold Spring Harbor Laboratories and at the Janelia Farm Research Campus.

ZACHARY KNIGHT, PHD University of California, San Francisco Dr. Knight is an Assistant Professor in the Department of Physiology at University of California, San Francisco (UCSF), where his lab is developing new technologies for mapping neural circuits by sequencing RNA and using these tools to identify the cells that control innate behaviors such as feeding. He completed his postdoctoral research at The Rockefeller University.

MELISSA WARDEN, PHD Cornell University Dr. Warden is an Assistant Professor in the Department of Neurobiology and Behavior at Cornell University and a Miriam M. Salpeter Fellow. Her work integrates neurophysiological, imaging, and cellular and molecular approaches to the understanding of neural circuits mediating reward, motivation, and learning. She completed her postdoctoral studies at Stanford University.


N Y S C F – R O B E RT S O N I N V E S T I G ATO R A L U M N I The NYSCF – Robertson Investigator Alumni continue to participate in the greater Innovator Community through The NYSCF Conference, the annual Innovators Retreat, and an ongoing series of collaborations and projects. They are part of a global network of scientists who are working to accelerate the path of research from bench to bedside.


2 0 1 2 N Y S C F – R O B E R T S O N S T E M C E L L I N V E S T I G ATO R A L U M N I DEEPTA BHATTACHARYA, PHD Associate Professor, University of Arizona Dr. Bhattacharya’s lab focuses on stem cell-based approaches for the treatment of immune deficiencies and on the molecular and cellular mechanisms of resistance to viral infection. He started his independent laboratory at Washington University School of Medicine before moving to University of Arizona.

DIETER EGLI, PHD Assistant Professor, Columbia University Dr. Egli focuses on the generation of therapeutically relevant cells for diabetes. His work has relevance for the use of stem cells to study disease, screen for new drugs, and cell replacement therapy. Previously, he conducted research at The NYSCF Research Institute.

ALEXANDER MEISSNER, PHD Professor, Harvard University Director, Max Planck Institute for Molecular Genetics, Germany Dr. Meissner is developing and applying next generation sequencing technologies to the human genome with the goal of better understanding normal and disease cellular states. He maintains a lab at Harvard.

2 0 1 2 N Y S C F – R O B E R T S O N N E U R O S C I E N C E I N V E S T I G ATO R A L U M N I CHRISTOPHER HARVEY, PHD Assistant Professor, Harvard Medical School Dr. Harvey’s lab focuses on understanding the neuronal circuit mechanisms underlying short-term memory and decision-making, using a range of imaging, electrophysiological, genetic, and behavioral approaches. He investigates how circuits perform computations, especially in the context of spatial navigation.

MICHAEL A. LONG, PHD Associate Professor, New York University School of Medicine Dr. Long and his lab aims to develop approaches that adapt modern imaging and electrophysiological tools to the study of neural circuits underlying the production of skilled motor behaviors.

VANESSA RUTA, PHD Assistant Professor, The Rockefeller University Dr. Ruta’s lab is using novel methods to trace and probe neural circuits to gain insight into the neural basis for innate and adaptive behaviors. Her lab has examined how the nervous system is wired to flexibly encode and assign meaning to the chemical world.


2 0 1 1 N Y S C F – R O B E R T S O N S T E M C E L L I N V E S T I G ATO R A L U M N I PAOLA ARLOTTA, PHD Professor, Harvard University Dr. Arlotta is investigating the mechanisms that control the development, regeneration and assembly of neurons in the cerebral cortex. Much of her work is aimed at identifying regenerative strategies for diseases of the corticospinal tract, including ALS and spinal cord injury.

GABSANG LEE, PHD Associate Professor, Johns Hopkins University School of Medicine Dr. Lee is studying stem cells created from the cells of patients with rare diseases like Familial Dysautonomia, Charcot-Marie-Tooth disease, and muscular dystrophy in order to investigate the development of these diseases and treatments and therapies.

RAVI MAJETI, MD, PHD Associate Professor, Stanford University Dr. Majeti focuses on the molecular and genomic characterization and therapeutic targeting of leukemia stem cells in human hematologic malignancies. He has isolated a protein, CD47, as a protector of cancer cells and looks to treat cancer by silencing it.

2 0 1 1 N Y S C F – R O B E R T S O N N E U R O S C I E N C E I N V E S T I G ATO R A L U M N I ED BOYDEN, PHD Associate Professor, Massachusetts Institute of Technology Dr. Boyden leads the Synthetic Neurobiology Group, which develops tools for controlling and observing the dynamic circuits of the brain, and uses these neurotechnologies to enable systematic repair of intractable brain disorders such as epilepsy, Parkinson’s disease, PTSD, and chronic pain.

CHRISTOPHER GREGG, PHD Assistant Professor, University of Utah Dr. Gregg is researching the function and regulation of imprinted genes expressed in circuits of the brain that modulate feeding and motivated behaviors. In particular, he is working to uncover epigenetic regulatory pathways that program gene expression in the brain during early life.

TAKAKI KOMIYAMA, PHD Associate Professor, University of California, San Diego Dr. Komiyama is interested in studying the activity of neuronal ensembles in behaving animals, and how it might change with experience and learning. His lab is among the pioneers to use in vivo two-photo calcium imaging in awake, behaving mice.

GABY MAIMON, PHD Associate Professor, The Rockefeller University Dr. Maimon and his lab aim to link the electrical activity of neurons and the biochemical action of molecules to their computational roles in animal behavior. His research program provides a platform for discovering basic mechanisms of how brains integrate, think, and decide.


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SHUIBING CHEN, PHD Associate Professor, Weill Cornell Medical College Dr. Chen focuses on manipulating stem cell fate using chemical and biological approaches generating functional tissues and organs that can be used for translational research. Her lab’s goal is to use these patient specific tissues and organs for replacement therapy.

DERRICK ROSSI, PHD Associate Professor, Harvard University Dr. Rossi is interested in understanding the mechanisms enabling self-renewal and multi-potency in hematopoietic stem cells, cells within the bone marrow, which he studies using cellular, molecular, genetic, and epigenetic approaches.

PAUL J. TESAR, DPHIL Associate Professor, Case Western Reserve University Dr. Tesar works on directed differentiation of stem cells into oligodendrocytes to study diseases such as multiple sclerosis. By comparing stem cells from different patients, he has a tractable system to study human developmental genetics and uncover new genetic or pharmacological therapies.

MARIUS WERNIG, MD, PHD Associate Professor, Stanford University Dr. Wernig is interested in pluripotent stem cell biology and the molecular determinants of neural cell fate decisions. His laboratory was the first to generate functional neuronal cells reprogrammed directly from skin fibroblasts, and is now working on cell transplantation-based strategies for a variety of monogenetic diseases.


N Y S C F – R O B E RT S O N STEM CELL PRIZE The NYSCF – Robertson Stem Cell Prize is awarded annually to an outstanding young stem cell scientist in recognition of significant and pathbreaking translational stem cell research. Each NYSCF – Robertson Stem Cell Prize Recipient receives a monetary award to be used for research purposes as well as a sculpture from The New York Stem Cell Foundation.


2017 NYSCF – ROBERTSON STEM CELL PRIZE RECIPIENT

2017 PAUL J. TESAR, DPHIL Dr. Tesar is an Associate Professor and the Dr. Donald and Ruth Weber Goodman Professor of Innovative Therapeutics at Case Western Reserve University, where his laboratory is developing cutting-edge stem cell technologies to better understand and treat nervous system disorders including multiple sclerosis, pediatric leukodystrophies, cerebral palsy, and brain cancer. Recently, Dr. Tesar has turned his attention to the study of myelination and the diseases that impact it. His work has helped move the field beyond the challenge of inaccessibility by devising new methods for producing myelinating oligodendrocytes through reprogramming and stem cell differentiation techniques. He has also delivered on the translational promise that these cells hold by using them as a substrate for drug screening efforts. His transformative discoveries are fundamentally enabling critical advances in stem cell biology and regenerative medicine. Dr. Tesar is a NYSCF – Robertson Stem Cell Investigator Alumnus.


NYSCF – ROBERTSON STEM CELL PRIZE RECIPIENTS

2016 FENG ZHANG, PHD Core Member of the Broad Institute of MIT and Harvard Associate Professor at Massachusetts Institute of Technology For the development of genome editing tools from CRISPR-Cas9 Dr. Zhang won the Prize for his development of the CRISPR-Cas9 gene editing system, using the technique in human cells. The CRISPR-Cas9 system and later advances, also developed by Zhang, are easy to execute with almost endless possibility for new research enabling scientists to change, delete, and replace any genes of any animal. His methods are being used in immunology, clinical medicine, and cancer biology.

2015 FRANZISKA MICHOR, PHD Professor at Dana-Farber Cancer Institute Professor at Harvard T.H. Chan School of Public Health For the development of novel, interdisciplinary approaches to treat cancer Dr. Michor won the Prize for her work pioneering new approaches to study the growth, spread, and treatment of cancer. Her quantitative approaches have called into question drug regimens for cancer treatments, in particular, chronic myelogenous leukemia (CML), a type of blood cell cancer. Dr Michor’s work simulates what happens if drugs are introduced in different time intervals in order to optimize treatment by reducing the amount of surviving cancer cells.

2014 MARIUS WERNIG, MD, PHD Associate Professor at Stanford University For a new method to generate neurons Dr. Wernig won the Prize for his discovery that human skin cells can be converted directly into functional neurons, termed induced neuronal (iN) cells. This new technique transformed the field of cellular reprogramming by eliminating the need to first create iPS cells, making it easier to generate patient or disease-specific neurons. These cell types hold tremendous therapeutic and translational relevance for patients around the world.


NYSCF – ROBERTSON STEM CELL PRIZE RECIPIENTS

2013 AMY J. WAGERS, PHD Professor at Harvard University For key insights into aging Dr. Wagers won the Prize for her discovery of a hormone, GDF11, that regulates aging through stem cell “rejuvenation”, which has the potential to provide transformative new therapies for aging and chronic degenerative diseases. Her work has the potential to impact treatment of diabetes, cancer, and muscular dystrophy among many other devastating conditions. Her lab focuses on the regulation and therapeutic potential of blood and muscle stem cells.

2012 KAZUTOSHI TAKAHASHI, PHD Investigator at Gladstone Institute of Cardiovascular Disease For the discovery of induced pluripotent stem cells Dr. Takahashi won the Prize for his vital contribution to induced pluripotent stem (iPS) cell derivation at Kyoto University, Japan. He was lead author on a series of landmark papers that described reprogramming adult cells into iPS cells, which were published while he was a postdoctoral researcher in the laboratory of Shinya Yamanaka, MD, PhD, winner of the 2012 Nobel Prize in Physiology and Medicine. His path-breaking work has opened up the field of stem cell research.

2011 PETER J. COFFEY, DPHIL Professor at University College London, United Kingdom Professor at University of California, Santa Barbara For the first stem cell trial to treat blindness Dr. Coffey won the Prize for his pioneering work in the use of human embryonic stem cells to halt visual deterioration and treat age-related eye diseases, resulting in the first clinical stem cell trials to attempt to treat blindness. His research has demonstrated that stem cell-based therapy halted visual deterioration in models of Aged-Related Macular Degeneration (AMD), a currently untreatable form of blindness affecting millions of people across the globe.


NYSCF RESEARCH INSTITUTE I N V E S T I G ATO R S Since its inception, The NYSCF Research Institute has used private funds to advance the most cuttingedge stem cell research. With the generous support of private philanthropists, the NYSCF Research Institute Investigators are moving the field of stem cell research closer to the cures we need.


­­N Y S C F R E S E A R C H I N S T I T U T E I N V E S T I G AT O R S GIUSEPPE MARIA de PEPPO, PHD  The NYSCF Research Institute 2015 ­­NYSCF – Ralph Lauren Investigator Dr. de Peppo is the NYSCF – Ralph Lauren Investigator at The NYSCF Research Institute, where he is focusing on engineering personalized bone substitutes for reconstructive therapies of the skeletal system, studying bone development and pathologies using patient-specific cells, and screening new drugs and testing biomaterials. Dr. de Peppo conducted his postdoctoral studies at The NYSCF Research Institute.

VALENTINA FOSSATI, PHD  The NYSCF Research Institute Dr. Fossati is a Senior Investigator at The NYSCF Research Institute, where she is using skin samples from patients with multiple sclerosis to create the oligodendrocytes affected by disease. Dr. Fossati received a NYSCF – Druckenmiller Fellowship in 2009 and conducted her postdoctoral studies at the Icahn School of Medicine at Mount Sinai.

BJARKI JOHANNESSON, PHD The NYSCF Research Institute Dr. Johannesson is an Investigator at The NYSCF Research Institute. He focuses on gaining a better understanding of why beta cells fail in diabetes as well as exploring ways to improve the survival of stem cell derived insulin producing cells after transplantation. He received his PhD from the European Molecular Biology Laboratory in Germany and a NYSCF – Druckenmiller Fellowship in 2014.

SCOTT NOGGLE, PHD The NYSCF Research Institute Dr. Noggle is Senior Vice President, Research at The NYSCF Research Institute, where his work focuses on using cell reprogramming to create new treatments for neurodegenerative diseases including Alzheimer’s disease and Parkinson’s disease, and developing new stem cell technologies. He completed his postdoctoral research at The Rockefeller University, and previously was named the NYSCF – Charles Evans Senior Research Fellow for Alzheimer’s Disease.

DANIEL PAULL, PHD The NYSCF Research Institute Dr. Paull is Vice President, Automation Systems & Stem Cell Biology at The NYSCF Research Institute, where he leads research on the NYSCF Global Stem Cell Array automated robotic stem cell derivation and differentiation system. He received his PhD from University College London, United Kingdom and completed his postdoctoral studies at The NYSCF Research Institute in Dr. Dieter Egli’s lab.


N Y S C F I N V E S T I G ATO R P R O G R A M S

I NS TIT U TI O NS O F CUR R E N T STEM C E L L I NVE ST I GATOR S Academic Medical Center, The Netherlands Broad Institute of MIT and Harvard California Institute of Technology Cincinnati Children's Hospital Medical Center Harvard Medical School Icahn School of Medicine at Mount Sinai Lund University, Sweden Massachusetts General Hospital Massachusetts Institute of Technology Stanford University University of Pennsylvania University of Southern California Weizmann Institute of Science, Israel

INST IT U TI O N S O F CUR R E N T NEURO S C I E NC E I N V E ST I GATOR S Boston Children's Hospital Brain & Spine Institute (ICM), France Cornell University Harvard Medical School Massachusetts Institute of Technology Princeton University Stanford University The Rockefeller University University of California, Berkeley University of California, San Francisco University of Geneva, Switzerland


Creating a global community of scientists leading their generation in cutting-edge research

I N ST I T UTI O NS O F NYS CF – RO BERTS O N S TEM CEL L PRI ZE RECIPI ENTS Broad Institute of MIT and Harvard Case Western Reserve University Dana-Farber Cancer Institute Harvard University Kyoto University, Japan Stanford University University College London, United Kingdom

I NS TITUTIO NS O F AL UMNI I NVES TI GATO RS Broad Institute of MIT and Harvard Case Western Reserve University School of Medicine Columbia University Harvard Medical School Harvard University Johns Hopkins University School of Medicine Massachusetts Institute of Technology Max Planck Institute for Molecular Genetics, Germany New York University School of Medicine The NYSCF Research Institute Stanford University The Rockefeller University University of Arizona University of California, San Diego University of Utah Washington University School of Medicine Weill Cornell Medical College


I M PAC T S I N CE TH E P RO G RA M ’S INC E PT ION

61

SCIENTISTS SUPPORTED

at

38

DIFFERENT INSTITUTIONS THROUGHOUT THE WORLD

NYSCF – ROBERTSON STEM CELL INVESTIGATORS NYSCF – ROBERTSON NEUROSCIENCE INVESTIGATORS NYSCF – ROBERTSON STEM CELL PRIZE RECIPIENTS ALUMNI

NYSCF RESEARCH INSTITUTE INVESTIGATORS

Over

850

YOUNG SCIENTISTS BEING TRAINED IN THEIR LABS

Over

2100

TOTAL PUBLICATIONS

Over

400

AWARDS & HONORS RECEIVED IN THEIR CAREERS

Over

2000

TALKS GIVEN ON THEIR EXCITING WORK


RESEARCH AREAS BY THE NUMBERS

A R E A S O F S T UDY 3%

Aging Autoimmune Diseases

3%

3%

10% 3% 8%

8%

Blindness Cancer Cardiovascular Diseases Diabetes

13%

Lung Diseases

13%

STEM CELL RESEARCH AREAS

Gene Editing/Human Genome Neurodegenerative Diseases Stem Cell Biology

3%

Tissue Engineering Alzheimer’s

General

Schizophrenia Rare Diseases

Multiple Sclerosis (MS)

Parkinson's Disease

14%

36%

Amyotrophic Lateral Sclerosis (ALS)

14% 23%

A REA S OF S TUDY

N EU RO SC IE NC E RESEARCH AREAS

Neurobiology Neurotechnologies Development

9%

41%

Learning & Memory Decision Making


­­N Y S C F I N N O V AT O R S

2

3

1

5

4

6

7

1. Dr. Feng Zhang; 2. Drs. Jay Rajagopal and Valentina Greco; 3. Drs. Michael Yartsev and Guiseppe Maria de Peppo; 4. Dr. Christopher Harvey; 5. Drs. Maria Lehtinen and Valentina Fossati; 6. Drs. Paul Tesar and Christopher Gregg; 7. NYSCF Innovators


­­N Y S C F L E A D E R S H I P

B OA R D O F D I R E C TO R S * NYSCF’S Board of Directors are leaders in medicine, the arts, and business. Their talents and experience, combined with an unwavering commitment to advancing stem cell research, guide NYSCF in realizing its mission. Roy Geronemus, MD, Chairman Susan L. Solomon, CEO & Co-founder Margo Alexander Peggy Brim Bewkes Marilyn G. Breslow Karen E. Burke, MD, PhD Paul Goldberger George Lazarus, MD Richard J. Massey, PhD Stephen M. Ross Stephen M. Scherr Stuart Smith, DPhil Anita Volz Wien

LEADERSHIP COUNCIL* NYSCF’S Leadership Council members are valued ambassadors who are committed to funding and promoting NYSCF’s mission to accelerate cures through stem cell research. Katherine Bristor & William Priest David A. Carmel Russell L. Carson Chuck Close Alan M. Cohen Shirley Cook Fiona & Stanley Druckenmiller Jodie & John Eastman Frank Gehry Lawrence E. Golub and Karen Finerman April Gornik Marlene Hess

Tania Higgins Dorothy Lichtenstein Sandra Lloyd Paul M. Meister Stephen J. Meringoff David K. Mitnick Nancy & Fred Poses Carol Roaman Julian Robertson Andy Russell Barbara Stovall Smith Noelle and Dick Wolf

*as of 9/25/2017


­­N Y S C F I N N O V AT O R S

• Maria Barna • Kristen Brennand • Valentina Greco Mitchell Guttman • Jacob Hanna • Justin Ichida • Malin Parmar • Sergiu Pasca Jennifer E. Phillips-Cremins • Jay Rajagopal • Kristy Red-Horse • Takanori Takebe • Louis Vermeulen Brian Wainger • Feng Zhang • NYSCF – Rober tson Neuroscience Investigators • Hillel Adesnik Stephen Brohawn • Edward Chang • Winrich Frewiald • Lisa Giocomo • Daniel Huber Zahcary Knight • Maria Lehtinen • Dragana Rogulja • Gregory Scherrer • Kay M. Tye Melissa Warden • Ilana Witten • Claire Wyart • Michael Yartsev • NYSCF – Rober tson Investigator Alumni Paola Arlotta • Deepta Bhattacharya • Ed Boyden • Shuibing Chen • Dieter Egli Christopher Gregg • Christopher Harvey • Takaki Komiyama • Gabsang Lee • Michael A. Long Gaby Maimon • Ravi Majeti • Alexander Meissner • Derrick Rossi • Vanessa Ruta • Paul J. Tesar Marius Wernig • NYSCF Research Institute Investigators • Valentina Fossati • Bjarki Johannesson Daniel Paull • Scott Noggle • NYSCF – Ralph Lauren Investigator • Giuseppe Maria de Peppo NYSCF – Helmsley Stem Cell Investigator Alumni • Valentina Fossati • Darja Marolt NYSCF – Dr uckenmiller Fellows • Laura Andres-Martin • Dafne Campigli Di Giammartino Tae Wan Kim • Hongda Li • Benjamin Lin • Raphael Lis • Ying Liu • Maria Maryanovich Sangbum Park • Brett Shook • Julia TCW • NYSCF – Dr uckenmiller Fellowship Alumni Sriram Bandi • Zhongwei Cao • Ting Chen • Elisa Cimetta • Dilek Colak • Francesco Paolo Di Giorgio Raffaella Di Micco • Bi-Sen Ding • Panos Douvaras • Dieter Egli • Samantha England • Elena Ezhkova Christopher Fasano • Nuria Flames • Valentina Fossati • Alexandre Gaspar Maia • Tamar Hermesh Ya-Chieh Hsu • Sarah Xuelian Huang • Justin Ichida • Keiichi Inoue • Daylon James Bjarki Johannesson • Natalie Kim • Evangelos Kiskinis • Fabien Lafaille • Dung-Fang Lee Gabsang Lee • Larry Luchsinger • Darja Marolt • Ian Martin • Maitane Ortiz-Virumbrales Dominik Paquet • Sandra Pinho • Christophe Raynaud • Pantelis Rompolas • Marco Seandel Jae-won Shim • Shivatra Noi Talchai • Wee-Wei Tee • Maya Tevlin • Maria Themeli Sjoukje van der Stegen • George Kai Wang • Yingying Zhang • Giovanni Zito • Oren Ziv NYSCF – Rober tson Stem Cell Pr ize Recipients • Peter J. Coffey • Franziska Michor Kazutoshi Takahashi • Paul J. Tesar • Amy J. Wagers • Marius Wernig • Feng Zhang NYSCF Research Institute • Kennedy Agwamba • Lauren Bauer Vensand • Katie Brenner Geoff Buckley-Herd • Sean DesMarteau • Panos Douvaras • Patrick Fenton • Eliana Forero Yosif Ganat • Jordan Goldberg • Jenna Hall • Ya-Chu Juliana Hsu • Christopher Hunter Tanya Jain • Travis Kroeker • Ilya Kruglikov • Gregory Lallos • Hector Martinez • Barry McCarthy Paul McCoy • Frederick Monsma • Dorota Moroziewicz • Melissa Nirenberg • Reid Otto Brandon Pearl • Katie Reggio • Tomasz Rusielewicz • Ana Sevilla • Martina Sladkova Bruce Sun • Edmund Tam • Cecile Terrenoire • Rebecca Tibbetts • Matthew Zimmer NYSCF – Rober tson Stem Cell Investigators

T H E N E W Y O R K S T E M C E L L F O U N D AT I O N


W W W. N Y S C F. O R G

The NYSCF Investigator Program  

The NYSCF Investigator Program supports early career scientists, creating and promoting a global community of leading stem cell and neurosci...

The NYSCF Investigator Program  

The NYSCF Investigator Program supports early career scientists, creating and promoting a global community of leading stem cell and neurosci...