The NYSCF Fellowship Program by The New York Stem Cell Foundation

THE NEW YORK STEM CELL FOUNDATION FELLOWSHIP PROGRAM Scientists leading their generation in stem cell research

2021 - 2022

Cover : Valentina Fossati, PhD, 2009 NYSCF – Druckenmiller Fellow Alumna

The New York Stem Cell Foundation is accelerating cures for the major diseases of our time through stem cell research.

N Y S C F I N N O V AT O R C O M M U N I T Y A global community of over 200 scientists leading their generation in cutting-edge research

The NYSCF Research Institute conducts advanced human stem cell research and develops pioneering technologies for the field. Independent and privately funded, NYSCF takes a “team science” approach to advance cures, collaborating with leading global partners to unravel the root causes of disease through the power of stem cells.

The NYSCF Investigator Program supports early career scientists, creating and promoting a global community of leading stem cell and neuroscience researchers. The Program provides support for: • NYSCF – Robertson Investigators • NYSCF – Robertson Stem Cell Prize Recipients

The NYSCF Fellowship Program supports postdoctoral scientists at an early stage in their careers. These young researchers hold the potential to accelerate treatments and cures. The Program provides support for: • NYSCF – Druckenmiller Fellows

NYSCF F E L L OW S H I P PROGRAM The New York Stem Cell Foundation Fellowship Program supports the most talented young postdoctoral scientists at critical junctures in their careers in the pursuit of innovative and groundbreaking stem cell research. The Program provides support for the NYSCF – Druckenmiller Fellowship Awards. Fellows are based at premier academic and medical institutions. All fellows receive an annual stipend and additional support. NYSCF fosters its community of young scientists through scientific retreats, an annual conference, career development training, and other events.

Support for the program is provided by Fiona and Stan Druckenmiller.

NYSCF FELLOWSHIP PROGRAM Creating a global community of scientists leading their generation in stem cell research

I N S T I T U T I O N S O F C U R R E N T F E L L OW S Columbia University Harvard University Stanford University The NYSCF Research Institute The Rockefeller University Weill Cornell Medical College Yale University

C U R R E N T I N S T I T U T I O N S O F A L U M N I F E L L OW S A*STAR-IMCB, Singapore Albert Einstein College of Medicine Angelini, Italy AstraZeneca, Sweden Bar-Ilan University, Israel Beam Therapeutics BlueRock Therapeutics Case Western Reserve University Columbia University Hackensack University Medical Center Harvard University Icahn School of Medicine at Mount Sinai Inanna Diagnostics

Institute of Biomedicine of Valencia, Spain Ionis Pharmaceuticals Johns Hopkins University Kite Pharma Ludwig Botzmann Institute, Austria Ludwig Maximilian University Munich, Germany Mayo Clinic Medeze, Singapore Mediterranean Institute for Transplantation and Advanced Specialized Therapies, Italy Memorial Sloan Kettering Cancer Center Michigan State University National Institute of Biological Sciences, China New York Blood Center

New York University School of Medicine Niigata University, Japan Northwestern University Oregon Health & Science University Regeneron Pharmaceuticals Rutgers University Sheba Tel HaShomer City of Health, Israel Sidra Medical and Research Center, Qatar Soonchunhyang University, South Korea Takeda, Spain Tara Biosystems The George Washington University The NYSCF Research Institute

The Rockefeller University The San Raffaele Telethon Institute for Gene Therapy, Italy University Medical Center Hamburg-Eppendorf, Germany University of Calgary, Canada University of Illinois at Chicago University of Padova, Italy University of Palermo, Italy University of Pennsylvania University of Southern California University of Texas Health Science Center VUmc Cancer Center Amsterdam, The Netherlands Weill Cornell Medical College Yale University

NYSCF – D RU C K E N M I L L E R F E L L OW S The New York Stem Cell Foundation – Druckenmiller Fellows are the leading young scientists in the field, advancing the most promising research in the pursuit of treatments and cures for the major diseases of our time. Through the Program, they are developing the scientific and leadership skills to advance their research and careers. The Program’s Alumni are an active and vibrant community, building the next generation of scientific leaders.

2021

NYSCF – DRUCKENMILLER FELLOWS

Julian Meyer Berger, PhD | Columbia University

Faculty Sponsor: Gerard Karsenty, MD, PhD Characterizing a New Role for Bone Cells in Hormone Regulation

Bone provides structural support for the body, but more recently, scientists have found that it also has important endocrine functions, producing hormones to help regulate bodily processes. Dr. Berger is identifying new hormones derived from bone, finding the cells that generate hormones within bone and designing novel therapeutics to enhance the bone endocrine system. This work may have widespread implications for diseases affected by the bone endocrine system, such as psychiatric diseases, neuromuscular junction disorders and metabolic syndromes.

Peter M.J. Quinn, PhD | Columbia University Faculty Sponsor: Stephen H. Tsang, MD Understanding Drivers of Retinal Eye Diseases

Dr. Quinn studies two disabling eye diseases, retinitis pigmentosa and Lebers congenital amaurosis, which damage the retina and lead to visual impairment from early childhood and birth. Using retinal organoids – 3D models of retinal eye tissue made from stem cells – Dr. Quinn is examining how variations in a gene called CRB1 may drive these diseases, opening the door for new treatment strategies.

Yulia Shwartz, PhD | Harvard University

Faculty Sponsor: Ya-Chieh Hsu, PhD Exploring and Optimizing Wound Healing in Aging Skin Dr. Shwartz uses stem cells to explore why our bodies become less efficient at wound healing as we age. She is creating tools to explore how different genes influence wound healing over time, aiming to identify methods for rejuvenating aged stem cells, which could help to address non-healing and chronic wounds.

2020

NYSCF – DRUCKENMILLER FELLOWS

Katie Cockburn, PhD | Yale University

Faculty Sponsor: Valentina Greco, PhD Understanding Where and When Stem Cells Become Skin Cells Dr. Cockburn is studying the process by which the human body replaces cells to keep its tissues working normally. Stem cells are the key to fueling cell replacement, and through a new technique she developed, Dr. Cockburn will visualize all stem cells in the skin of living adult mice to identify exactly when stem cells start to become skin cells. With this approach, she is aiming to shed light on the causes of skin diseases and cancer, as well as the development of novel regenerative medicine and therapies.

Katherine Stewart, PhD | The Rockefeller University Faculty Sponsor: Elaine Fuchs, PhD Understanding Why Stem Cells Clear Up Dying Cells Dr. Stewart aims to understand how the body clears dying cells to make way for fresh, healthy cells. She has recently discovered that the stem cells that replace hair, usually primarily associated with replenishing and repairing cells, also are involved in removing dying neighbor cells – an ability that has never been linked to any type of stem cell before. She is planning to further research why stem cells engage in this behavior, which could advance insight into skin regeneration.

Yongjin Yoo, PhD | Stanford University Faculty Sponsor: Marius Wernig, MD, PhD Developing Safe Therapies for Brain Disease and Degeneration Dr. Yoo is researching cell therapies for brain disorders. He and his colleagues have developed a highly efficient method to replace virtually all microglia, the immune cells of the brain, with cells derived from bone marrow. Currently, the replacement method can only be carried out through chemotherapy, which can cause life threatening side effects and limits the ability to introduce genetically engineered cells. He is aiming to develop solutions to these limitations to develop a non-invasive and safe microglia replacement protocol.

2019

NYSCF – DRUCKENMILLER FELLOWS

Filippo Cipriani, PhD | The NYSCF Research Institute

Faculty Sponsor: Scott Noggle, PhD Modeling Diabetes in Patient Populations with Stem Cell-Derived Pancreatic Cells

Dr. Cipriani’s research is focused on using stem cells to develop robust models of diabetes on a large scale, to capture how the disease affects diverse patient populations. By leveraging the NYSCF Global Stem Cell Array®, the NYSCF Research Institute’s automated platform for stem cell production, he will develop a fully automated approach for the generation of patient-specific, stem-cell-derived pancreatic cells, minimizing experimental variation. This population-based disease modeling of diabetes will help scientists understand how the disease varies across patients.

Jesus M. Gomez Salinero, PhD | Weill Cornell Medical College Faculty Sponsor: Shahin Rafii, MD Engineering Liver Cells from Stem Cells for Regenerative Medicine

Dr. Gomez Salinero is interested in curing end-stage liver disease. His research focuses on creating liver cells from stem cells that can be effectively integrated into their new home: the injured liver. To overcome challenges in making these cells functional and long-lived, he is creating liver scaffolds that mimic the environment of developing liver cells. This research will inform the development of liver regeneration therapies which could serve as an advantageous alternative to transplants for patients with liver failure.

Tatiana Volpari, PhD | The NYSCF Research Institute

Faculty Sponsor: Laura Andres-Martin, PhD Building a Biobank to Advance Precision Medicine in Ovarian Cancer

Dr. Volpari is creating a ‘living biobank’ of patient-specific ovarian cancer tumor samples to advance research and treatments as part of the NYSCF Women’s Reproductive Cancers Initiative. Building on the self-renewing properties of tumors, she will create ‘organoid’ models of tumors from hundreds of patients; these organoids provide an unlimited supply of tumor tissue for research and testing therapies. This research will lay the groundwork for clinical strategies to select which therapies are most likely to be effective for each patient, addressing a major unmet need for this type of cancer.

N Y S C F F E L L O W S H I P

Alumni Y EA R

N AM E & CUR R ENT T I T L E

CURRENT I N S T I T U T I ON

F E L L OW S H I P H E L D AT:

2020

Hiroko Nobuta Assistant Professor

Rutgers University

Albert Einstein College of Medicine

2019

Stephanie Ellis Postdoctoral Associate

The Rockefeller University

Case Western Reserve University

Tianchi Xin Postdoctoral Associate

Yale University

Ly-sha Ee Postdoctoral Associate

Weill Cornell Medical College

Ana Freire Postdoctoral Associate

Hackensack University Medical Center

Memorial Sloan Kettering Cancer Center

Regeneron Pharmaceuticals

Columbia University

Albert Einstein College of Medicine

Weill Cornell Medical College

Albert Einstein College of Medicine

Sangbum Park Assistant Professor

Michigan State University

Yale University

Julia TCW Instructor

Icahn School of Medicine at Mount Sinai

Tae Wan Kim Research Fellow

Memorial Sloan Kettering Cancer Center

Benjamin Lin Postdoctoral Associate

NYU School of Medicine

Ying Liu Postdoctoral Associate

Weill Cornell Medical College

Marissa Scavuzzo Postdoctoral Fellow

2018

Kosuke Funato Senior Research Scientist Alexandros Strikoudis Scientist Samuel Taylor Postdoctoral Associate

2017

Raphael Lis Assistant Professor Maria Maryanovich Associate Faculty

2016

2015

Laura Andres-Martin Research Investigator

The NYSCF Research Institute

Weill Cornell Medical College

Dafne Campigli Di Giammartino Research Associate

Weill Cornell Medical College

Ionis Pharmaceuticals

The Rockefeller University

The George Washington University

Yale University

Sjoukje van der Stegen Research Associate

Memorial Sloan Kettering Cancer Center

Zhongwei Cao Assistant Professor

Icahn School of Medicine at Mount Sinai

Weill Cornell Medical College

Panos Douvaras Senior Scientist

BlueRock Therapeutics

The NYSCF Research Institute

Bjarki Johannesson Associate Director

AstraZeneca, Sweden

The NYSCF Research Institute

Mayo Clinic

Icahn School of Medicine at Mount Sinai

Takeda, Spain

Icahn School of Medicine at Mount Sinai

Ludwig Maximilian University Munich, Germany

The Rockefeller University

Maria Themeli Assistant Professor

VUmc Cancer Center Amsterdam, The Netherlands

Memorial Sloan Kettering Cancer Center

Raffaella Di Micco Principal Investigator

The San Raffaele Telethon Institute for Gene Therapy, Italy

NYU School of Medicine

Larry Luchsinger Principal Investigator

New York Blood Center

Columbia University

University of Illinois at Chicago

Albert Einstein College of Medicine

Pantelis Rompolas Assistant Professor

University of Pennsylvania

Yale University

Samantha England Research Technician

University of Calgary, Canada

University of Rochester Medical Center

BlueRock Therapeutics

The Rockefeller University

A*STAR-IMCB, Singapore

NYU School of Medicine

Beam Therapeutics

Harvard University

Hongda Li Assistant Director Brett Shook Assistant Professor

2014

Alexandre Gaspar Maia Assistant Professor Maitane Ortiz-Virumbrales Senior Scientist Dominik Paquet Professor

2013

Sandra Pinho Assistant Professor

2012

Fabien Lafaille Senior Scientist Wee-Wei Tee Principal Investigator Yingying Zhang Principal Scientist

Y EA R

2011

N AM E & CUR R ENT T I T L E

CURRENT I N S T I T U T I ON

F E L L OW S H I P H E L D AT:

Dilek Colak Assistant Professor

Weill Cornell Medical College

Bi-Sen Ding Assistant Professor

Icahn School of Medicine at Mount Sinai

Weill Cornell Medical College

Tamar Hermesh Pyschiatry Resident

Sheba Tel HaShomer City of Health, Israel

The Rockefeller University

Ya-Chieh Hsu Associate Professor

Harvard University

The Rockefeller University

University of Texas Health Science Center

Icahn School of Medicine at Mount Sinai

Northwestern University

Harvard University

Sidra Medical and Research Center, Qatar

Weill Cornell Medical College, Qatar

Mediterranean Institute for Transplantation and Advanced Specialized Therapies, Italy

Yale University

University of Padova, Italy

Columbia University

University Medical Center Hamburg-Eppendorf, Germany

Harvard University

Ian Martin Assistant Professor

Oregon Health & Science University

Johns Hopkins University

Jae-won Shim Associate Professor

Soonchunhyang University, South Korea

Memorial Sloan Kettering Cancer Center

Medeze, Singapore

Columbia University

Inanna Diagnostics

The Rockefeller University

Tara Biosystems

Columbia University

Bar-Ilan University, Israel

The Hebrew University of Jerusalem, Israel

Sarah Xuelian Huang Assistant Professor Evangelos Kiskinis Assistant Professor Christophe Raynaud Senior Staff Scientist Giovanni Zito Researcher

2010

Elisa Cimetta Associate Professor Natalie Kim Senior Scientist

Shivatra Noi Talchai Chief Scientific Officer Maya Tevlin Founder and CEO George Kai Wang Research Scientist Oren Ziv Lab Manager

2009

Nuria Flames Principal Investigator Valentina Fossati Senior Research Investigator

2008

2007

The NYSCF Research Institute

Columbia University Icahn School of Medicine at Mount Sinai/ The NYSCF Research Institute

Dung-Fang Lee Assistant Professor

University of Texas Health Science Center

Icahn School of Medicine at Mount Sinai

Gabsang Lee Associate Professor

Johns Hopkins University

Memorial Sloan Kettering Cancer Center

National Institute of Biological Sciences, China

The Rockefeller University

Dieter Egli Assistant Professor

Columbia University

The NYSCF Research Institute

Marco Seandel Associate Professor

Weill Cornell Medical College

Weill Cornell Medical College/ Memorial Sloan Kettering Cancer Center

Sriram Bandi Associate Director

Kite Pharma

Albert Einstein College of Medicine

Francesco Paolo Di Giorgio Global Head of Research and Development

Angelini, Italy

The Salk Institute/ Harvard University

Justin Ichida Associate Professor

University of Southern California

Harvard University

Keiichi Inoue Assistant Professor

Niigata University, Japan

Columbia University

Daylon James Assistant Professor

Weill Cornell Medical College

Ludwig Botzmann Institute, Austria

Columbia University

Icahn School of Medicine at Mount Sinai

The Rockefeller University

Ting Chen Associate Investigator

Darja Marolt Group Leader

2006

Institute of Biomedicine of Valencia, Spain

Elena Ezhkova Professor

Impact

SINCE THE PROGRAM’S INCEPTION 80

OUTSTANDING FELLOWS SUPPORTED

NUMBER OF FELLOWS

50 NEWLY AWARDED FELLOWS 40

2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021

YEAR

59%

OF ALUMNI HOLD LEADERSHIP POSITIONS IN SCIENCE

Over

1400

TOTAL PUBLICATIONS

97%

OF ALUMNI ARE ACTIVELY PURSUING THEIR SCIENTIFIC CAREERS

Research Areas by the Numbers

10% 3%

17% 26%

STEM CELL RESEARCH AREAS

26% 1%

8% 5%

AREAS OF STUDY Autoimmune Diseases

Cancer & Blood Diseases

Cardiovascular Diseases

Diabetes

Liver Diseases

Lung Diseases

Neurodegenerative Diseases

Stem Cell Biology

Tissue Engineering

NYSCF thanks Fiona and Stan Druckenmiller for their pioneering and long-standing support of this program.

Top row from left: Dr. Ana Freire; Dr. Jesus Gomez Salinero; Dr. Marissa Scavuzzo; Drs. Ying Liu and Ly-sha Ee

NYSCF Innovator Retreat A Virtual Week of Scientific Discourse and Continued Camaraderie | May, 2021

Bottom: NYSCF Innovators

N Y S C F – RO B E RT S O N STEM CELL INVESTIGATORS Maria Barna Raffaella Di Micco Ya-Chieh Hsu Vikram Khurana Evangelos Kiskinis Florian Merkle Samantha Morris José Ordovás-Montañés Malin Parmar Sergiu Pasca Vijay Sankaran Takanori Takebe Louis Vermeulen Brian Wainger Kevin C. Wang

N Y S C F – RO B E RT S O N STEM CELL PRIZE RECIPIENTS Peter J. Coffey Franziska Michor Kazutoshi Takahashi Paul J. Tesar Amy J. Wagers Marius Wernig Feng Zhang

NYSCF RESEARCH INSTITUTE I N V E S T I G ATO R S Laura Andres-Martin Gist Croft Valentina Fossati Scott Noggle Daniel Paull

NYSCF – RALPH LAUREN I N V E S T I G ATO R Giuseppe Maria de Peppo

NYSCF – HELMSLEY STEM CELL INVESTIGATOR ALUMNI Valentina Fossati Darja Marolt

N Y S C F – RO B E RT S O N NEUROSCIENCE INVESTIGATORS Dmitriy Aronov Nicholas Bellono Stephen Brohawn Jiami Guo Elaine Y. Hsiao Maria Lehtinen Carolyn (Lindy) McBride Lauren O’Connell Yuki Oka Gregory Scherrer David Schneider John Tuthill Ilana Witten Claire Wyart Michael Yartsev

N Y S C F – RO B E RT S O N I N V E S T I G ATO R A L U M N I Hillel Adesnik Paola Arlotta Deepta Bhattacharya Ed Boyden Kristen Brennand Edward Chang Shuibing Chen Dieter Egli Winrich Freiwald Lisa Giocomo Valentina Greco Christopher Gregg Mitchell Guttman Jacob Hanna Christopher Harvey Daniel Huber Justin Ichida Zachary Knight Takaki Komiyama Gabsang Lee Michael A. Long Gaby Maimon Ravi Majeti Alexander Meissner Jennifer E. Phillips-Cremins Jay Rajagopal Kristy Red-Horse Dragana Rogulja Derrick Rossi Vanessa Ruta Paul J. Tesar Kay M. Tye Melissa Warden Marius Wernig Feng Zhang

N YS C F – D RU C K E N M I L L E R F E L L OW S Peter M.J. Quinn Jesus M. Gomez Salinero Yulia Shwartz

Julian Meyer Berger Filippo Cipriani Katie Cockburn

Katherine Stewart Tatiana Volpari Yongjin Yoo

N YS C F – D RU C K E N M I L L E R F E L L OW S H I P A L U M N I Laura Andres-Martin Sriram Bandi Dafne Campigli Di Giammartino Zhongwei Cao Ting Chen Elisa Cimetta Dilek Colak Francesco Paolo Di Giorgio Raffaella Di Micco Bi-Sen Ding Panos Douvaras Ly-sha Ee Dieter Egli Stephanie Ellis Samantha England Elena Ezhkova Nuria Flames Valentina Fossati Ana G. Freire Kosuke Funato Alexandre Gaspar Maia Tamar Hermesh

Dominik Paquet Sangbum Park Sandra Pinho Christophe Raynaud Pantelis Rompolas Marissa A. Scavuzzo Marco Seandel Jae-won Shim Brett Shook Alexandros Strikoudis Shivatra Noi Talchai Samuel Taylor Julia TCW Wee-Wei Tee Maya Tevlin Maria Themeli Sjoukje van der Stegen George Kai Wang Tianchi Xin Yingying Zhang Giovanni Zito Oren Ziv

Ya-Chieh Hsu Sarah X.L. Huang Justin Ichida Keiichi Inoue Daylon James Bjarki Johanesson Natalie Kim Tae Wan Kim Evangelos Kiskinis Fabien Lafaille Dung-Fang Lee Gabsang Lee Hongda Li Benjamin Lin Raphael Lis Ying Liu Larry Luchsinger Darja Marolt Ian Martin Maria Maryanovich Hiroko Nobuta Maitane Ortiz-Virumbrales

NYSCF RESEARCH INSTITUTE SCIENTISTS & ENGINEERS Paula Alonso-Guallart Alexander Anneling Zefe Baez Lauren Bauer Margaux Berliss Geoff Buckley-Herd Kolawole Campbell John Cerrone Yu-Ren Chen Filippo Cipriani Nathan Dale Drew Daly Sean DesMarteau Oriana Di Caro Ally Duren-Lubanski Brodie Fischbacher Camille Fulmore Tiffany Gibson

Jordan Goldberg Ankush Goyal Jenna Hall Jax Hebner Lilian Ho Grayson Horn Christopher Hunter Dillion Hutson Laraib Ijaz Selwyn Jacob Harshad Joshi Kriti Kalpana Howard Kim Manisha Kintali Ilya Kruglikov David Labib Davide Marotta Hector Martinez Barry Mc Carthy

Paul McCoy Dayna McKenzie Connor McKnight Bianca Migliori Andrew Mikosz Rhoda Mondeh-Lowor Rick Monsma Dorota Moroziewicz Humayun Munir Manali Nikte Enya O’Connor Reid Otto Brandon Pearl Victor Ramirez Kiran Ramnarine Chandrika Rao Katie Reggio Andrew Reiter

Madelin Rivera Tomasz Rusielewicz Michael Santos Maria Sapar Jacob Simon Marta Skowronska Martina Sladkova Cecile Terrenoire Regine Tipon Tatiana Volpari Yinan Wang Josephine Wesely Daniel White Caroline Wilson James Woods Ming-ming Zhou Matthew Zimmer

N Y S C F I N N O V AT O R S

N Y S C F L E A D E R S H I P

B OA R D O F D I R E C TO RS

NYSCF’S Board of Directors are leaders in medicine, the arts, and business. Their talents and experience, combined with an unwavering commitment to advancing stem cell research, guide NYSCF in realizing its mission. Roy Geronemus, MD, Chairman Susan L. Solomon, CEO Margo Alexander Marilyn G. Breslow Peggy Brim Karen E. Burke, MD, PhD Francesco Clark Paul Goldberger George Lazarus, MD Richard J. Massey, PhD Paul M. Meister Siddhartha Mukherjee, MD, DPhil Stephen M. Ross Derrick Rossi, PhD Stephen M. Scherr Kay Unger Clyde Williams LEADERSHIP COUNCIL

NYSCF’S Leadership Council members are valued ambassadors who are committed to funding and promoting NYSCF’s mission to accelerate cures through stem cell research. Katherine Bristor & William Priest David A. Carmel Russell L. Carson Chuck Close Alan M. Cohen Shirley Cook Fiona Druckenmiller Jodie & John Eastman Frank Gehry Lawrence E. Golub & Karen Finerman April Gornik Marlene Hess Tania Higgins Dorothy Lichtenstein Sandra Lloyd

Stephen Meringoff David Mitnick Nancy & Fred Poses Carol Roaman Julian Robertson Clifford Ross Kara Ross Andy Russell Susan & Stephen Scherr Ian Schrager Barbara Stovall Smith Martha Stewart David & Jane* Walentas John Whitehead* Dick Wolf *In Memoriam

As of June 1, 2021