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THE NEW YORK STEM CELL FOUNDATION FELLOWSHIP PROGRAM Scientists leading their generation in stem cell research

2017 - 2018


Cover : (L) Panos Douvaras, PhD, 2014 NYSCF – Druckenmiller Fellow Alumnus, and (R) Maitane Ortiz-Virumbrales, PhD, 2014 NYSCF – Druckenmiller Fellow Alumna


The New York Stem Cell Foundation is accelerating cures for the major diseases of our time through stem cell research.


NYSCF INNOVATOR COMMUNITY A global community of over 140 scientists leading their generation in cutting-edge research

The NYSCF Research Institute Laboratories conduct the most advanced human stem cell research and develop pioneering technologies for the field. Independent and privately funded, NYSCF takes a “team science” approach to advance cures, collaborating with leading global partners to unravel the root causes of disease through the power of stem cells.

The NYSCF Investigator Program supports early career scientists, creating and promoting a global community of leading stem cell and neuroscience researchers. The Program provides support for: • NYSCF – Robertson Investigators • NYSCF – Robertson Stem Cell Prize Recipients

The NYSCF Fellowship Program supports postdoctoral scientists at an early stage of their careers.These young researchers hold the potential to accelerate treatments and cures.The Program provides support for: • NYSCF – Druckenmiller Fellows


NYSCF FELLOWSHIP PROGRAM The New York Stem Cell Foundation Fellowship Program supports the most talented young postdoctoral scientists at critical junctures in their careers in the pursuit of innovative and groundbreaking stem cell research. The Program provides support for the NYSCF – Druckenmiller Fellowship Awards. Fellows are based at premier academic and medical institutions. All fellows receive an annual stipend and additional support. NYSCF fosters its community of young scientists through scientific retreats, an annual conference, and other events. Support for the program is provided by Fiona and Stan Druckenmiller.


2017 ­­NYSCF – DRUCKENMILLER FELLOWS RAPHAEL LIS, PHD Weill Cornell Medical College Faculty Sponsor: Shahin Rafii, MD Transplanting Stem Cells to Treat Sickle Cell Anemia Dr. Lis is aiming to find a cure for sickle cell anemia, a disorder that causes red blood cells to become misshapen and break down. He hopes to both study the disease and develop a potential treatment by correcting the mutation in tissue from affected patients and then converting the corrected cells to blood stem cells. These stem cells should eventually develop into healthy blood cells. This research could provide an approach to generate an unlimited supply of healthy red blood cells to replace the deformed ones caused by the sickle cell mutation.

MARIA MARYANOVICH, PHD Albert Einstein College of Medicine Faculty Sponsor: Paul Frenette, MD Understanding How Aging Affects Blood Stem Cell Production Dr. Maryanovich is studying the effects of aging on the environment in which blood stem cells are produced. Her preliminary research has shown that aging leads to the loss of nerves that penetrate the bone marrow, and that adding back neural signals to older bone marrow can significantly rejuvenate blood stem cell function. Her research will specifically evaluate the role of nerves on the longevity of stem cells that support blood formation. This approach will help advance therapies for blood diseases associated with aging.

SANGBUM PARK, PHD Yale University Faculty Sponsor: Valentina Greco, PhD Studying the Interaction Between Skin Stem Cells and the Immune System Dr. Park’s research focuses on wound repair, a complex process that requires the participation of multiple cell types coexisting in the tissue. A key goal is to understand how stem cells and immune cells interact during the repair process. Dr. Park will first identify changes in the real-time behaviors of immune cells that are associated with stem cell behaviors and then define the functional interactions between these two cell types in different parts of the skin. These studies will help scientists better understand chronic wound repair and tissue regeneration.

JULIA TCW, PHD Icahn School of Medicine at Mount Sinai Faculty Sponsor: Alison Goate, PhD Using Stem Cells to Study Genetic Factors for Alzheimer’s Disease Dr. TCW is interested in understanding Alzheimer’s disease. Her research is focused on a mutant form of Apolipoprotein E (APOE), a major genetic risk factor for Alzheimer’s disease. These studies will provide an opportunity to evaluate the APOE genetic contribution to neurodegeneration associated with the disease by using brain cells derived from human induced pluripotent stem cells. Through this research, Dr. TCW hopes to better understand how the APOE gene mutation specifically contributes to Alzheimer’s.


2016 ­­NYSCF – DRUCKENMILLER FELLOWS TAE WAN KIM, PHD Memorial Sloan Kettering Cancer Center Faculty Sponsor: Lorenz Studer, MD Studying Cell Replacement Therapy to Treat Parkinson’s Disease Dr. Kim is working on a cell replacement therapy as a treatment for Parkinson’s disease by utilizing stem cells to permanently repair and replace damaged cells in the brain. While the current protocols may be sufficient to initiate early stage clinical trails, there is ample room to further improve on the final brain cell product that results from these stem cells. This treatment would effectively provide an unlimited source of healthy brain cells and stand as an alternative to current pharmacological methods.

BENJAMIN LIN, PHD New York University School of Medicine Faculty Sponsor: Ruth Lehmann, PhD Visualizing the Movement of Stem Cells for Potential Use in Regenerative Medicine Dr. Lin studies stem cells that naturally exist in our bodies and transport themselves to different parts of the body where they are needed for cell repair or regeneration. In order to understand how these stem cells can be utilized to enhance regeneration, he is working to identify how these cells release themselves from their starting positions in the body and how they move to the next location. This research has implications to improve upon stem cell based transplantation therapies.

YING LIU, PHD Weill Cornell Medical College Faculty Sponsor: Shahin Rafii, MD Exploring the Role of Key Genes in Stem Cell Regulation Dr. Liu is aiming to uncover the defects that are responsible for male infertility by identifying key changes to the chromosome that could potentially prevent the deleterious effects of cancer treatments, such as chemotherapy or radiation, which can result in sterility in up to 50% of patients. This research could lead to treatments to prevent or even reverse infertility and lead to the development of a method to convert stem cells into functional reproductive cells.


2015 ­­NYSCF – DRUCKENMILLER FELLOWS LAURA ANDRES-MARTIN, PHD Weill Cornell Medical College Faculty Sponsor: Marco Seandel MD, PhD Using Stem Cells to Understand How Mutations Can Cause Diseases Dr. Andres-Martin is exploring the effect paternal age has on the incidence of complex disorders in children, such as autism, schizophrenia, congenital heart disease, and cancer. She has identified this paternal age effect (PAE) resulting in mutant sperm-forming stem cells of older fathers, where these mutant cells are in competition with normal cells. She also intends to screen for mutant reproductive cells as a preventative clinical measure.

DAFNE CAMPIGLI DI GIAMMARTINO, PHD Weill Cornell Medical College Faculty Sponsor: Effie Apostolou, PhD Understanding Cellular Identity for Applications in Regenerative Medicine Dr. Campigli Di Giammartino is aiming to shed light on a novel mechanism that induces normal cell types to acquire stem cell-like properties. The current understanding of this process revolves around the presence of specific transcription factors, proteins involved in gene expression. Her research supports the notion that physical rearranging of chromatin, the building blocks of chromosomes, is also an important part of the process.

HONGDA LI, PHD The Rockefeller University Faculty Sponsor: Joseph G. Gleeson, MD Modeling a Neurodevelopmental Disorder Using Stem Cells Dr. Li’s research focuses on primacy microcephaly (PM), a neurodevelopmental disorder characterized by a reduction in brain size at birth, usually caused by defects in cell division. He has identified mutations in proteins involved in cell division in PM patients and plans to create stem cell models to better understand the role these mutations might have in the process of cell division. He will further test some therapeutic solutions for the disorder, which currently has no cure.

BRETT SHOOK, PHD Yale University Faculty Sponsor: Valerie Horsley, PhD Understanding How Fat Cells Contribute to Wound Healing Dr. Shook is working to understand how the myriad of skin cell types interact to efficiently drive stem cell-mediated repair of chronic skin wounds. He is focusing specifically on fat cells, one of the most abundant but overlooked components of skin. His findings show that fat cells change their own gene expression and identity in the presence of wounds and play a crucial role in wound healing. This research has tremendous potential application in the treatment of chronic wounds in diabetic patients.


NYSCF FELLOWSHIP ALUMNI YEA R

NAM E & CURR E NT T I T LE

C UR R E NT I NSTI T U T I O N

FE L L OW S H I P H E L D AT:

2015

SJOUKJE VAN DER STEGEN Research Fellow

2014

ZHONGWEI CAO Instructor

Weill Cornell Medical College

Weill Cornell Medical College

PANOS DOUVARAS Staff Scientist

The NYSCF Research Institute

The NYSCF Research Institute

BJARKI JOHANNESSON NYSCF Investigator

The NYSCF Research Institute

The NYSCF Research Institute

Icahn School of Medicine at Mount Sinai

Icahn School of Medicine at Mount Sinai

TiGenix, Spain

Icahn School of Medicine at Mount Sinai

DOMINIK PAQUET Professor

Ludwig-Maximilians-University Munich, Germany

The Rockefeller University

MARIA THEMELI Senior Research Fellow

VUmc Cancer Center Amsterdam, The Netherlands

Memorial Sloan Kettering Cancer Center

Columbia University

Columbia University

RAFFAELLA DI MICCO Principal Investigator

The San Raffaele Telethon Institute for Gene Therapy, Italy

New York University School of Medicine

SANDRA PINHO Associate

Albert Einstein College of Medicine

Albert Einstein College of Medicine

University of Pennsylvania

Yale University

University of Calgary, Canada

University of Rochester Medical Center

FABIEN LAFAILLE Postdoctoral Fellow

The Rockefeller University

The Rockefeller University

WEE-WEI TEE Principal Investigator

A*STAR, IMCB, Singapore

New York University School of Medicine

Dana Farber Cancer Institute

Harvard University

ALEXANDRE GASPAR MAIA Instructor MAITANE ORTIZ-VIRUMBRALES Senior Scientist (R&D)

2013

LARRY LUCHSINGER Associate Research Scientist

PANTELIS ROMPOLAS Assistant Professor

2012

SAMANTHA ENGLAND Research Technician

YINGYING ZHANG Senior Scientist

Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center


NYSCF FELLOWSHIP ALUMNI YEA R

2011

NAM E & CURR E NT T I T LE

C UR R E NT I NSTI T U T I O N

FE L L OW S H I P H E L D AT:

DILEK COLAK Assistant Professor

Weill Cornell Medical College

Weill Cornell Medical College

BI-SEN DING Assistant Professor

Weill Cornell Medical College

Weill Cornell Medical College

Tel Aviv University, Israel

The Rockefeller University

Harvard University

The Rockefeller University

University of Texas Health Science Center

Icahn School of Medicine at Mount Sinai

Northwestern University

Harvard University

Sidra Medical and Research Center, Qatar

Weill Cornell Medical College, Qatar

University of Palermo, Italy

Yale University

University of Padova, Italy

Columbia University

University Medical Center Hamburg-Eppendorf, Germany

Harvard University

IAN MARTIN Assistant Professor

Oregon Health & Science University

Johns Hopkins University

JAE-WON SHIM Assistant Professor

Soonchunhyang University, South Korea

Memorial Sloan Kettering Cancer Center

TAMAR HERMESH Accelerated Medical Program Student YA-CHIEH HSU Assistant Professor SARAH XUELIAN HUANG Assistant Professor EVANGELOS KISKINIS Assistant Professor CHRISTOPHE RAYNAUD Staff Scientist GIOVANNI ZITO Research Associate

2010

ELISA CIMETTA Assistant Professor NATALIE KIM Senior Scientist

SHIVATRA NOI TALCHAI Principal Investigator MAYA TEVLIN Research Scientist GEORGE KAI WANG Associate Research Scientist OREN ZIV Lab Manager

King Mongkut’s University of Technology Columbia University Thonburi, Thailand The Feinstein Institute for Biomedical Research

The Rockefeller University

Columbia University

Columbia University

Bar-Ilan University, Israel

The Hebrew University of Jerusalem, Israel


NYSCF FELLOWSHIP ALUMNI YEA R

2009

NAM E & CURR E NT T I T LE

NURIA FLAMES Principal Investigator VALENTINA FOSSATI NYSCF Senior Investigator DUNG-FANG LEE Assistant Professor GABSANG LEE Associate Professor

2008

TING CHEN Assistant Investigator DIETER EGLI Assistant Professor

Institute of Biomedicine of Valencia, Spain

Columbia University

The NYSCF Research Institute

Icahn School of Medicine at Mount Sinai/ The NYSCF Research Institute

University of Texas Health Science Center

Icahn School of Medicine at Mount Sinai

Johns Hopkins University

Memorial Sloan Kettering Cancer Center

National Institute of Biological Sciences, The Rockefeller University China The NYSCF Research Institute

New York Neural Stem Cell Institute

New York Neural Stem Cell Institute

Weill Cornell Medical College

Weill Cornell Medical College/ Memorial Sloan Kettering Cancer Center

Albert Einstein College of Medicine

Albert Einstein College of Medicine

Angelini, Italy

The Salk Institute/ Harvard University

JUSTIN ICHIDA Assistant Professor

University of Southern California

Harvard University

KEIICHI INOUE Assistant Professor

Columbia University

Columbia University

DAYLON JAMES Assistant Professor

Weill Cornell Medical College

Weill Cornell Medical College

DARJA MAROLT Group Leader

Ludwig Botzmann Institute, Austria

Columbia University

MARCO SEANDEL Assistant Professor

SRIRAM BANDI Research Scientist

FRANCESCO PAOLO DI GIORGIO Head of Research & Development

2006

FE L L OW S H I P H E L D AT:

Columbia University

CHRISTOPHER FASANO Former Director of R&D

2007

C UR R E NT I NSTI T U T I O N

ELENA EZHKOVA Associate Professor

Icahn School of Medicine at Mount Sinai The Rockefeller University


NYSCF FELLOWSHIP PROGRAM

INSTITUTIONS OF ALUMNI FELLOWS Albert Einstein College of Medicine Columbia University Harvard University Icahn School of Medicine at Mount Sinai Johns Hopkins University Memorial Sloan Kettering Cancer Center New York Neural Stem Cell Institute New York University School of Medicine The Hebrew University of Jerusalem, Israel The NYSCF Research Institute The Rockefeller University The Salk Institute University of Rochester Medical Center Weill Cornell Medical College Weill Cornell Medical College, Qatar Yale University

INSTITUTIONS OF CURRENT FELLOWS Albert Einstein College of Medicine Icahn School of Medicine at Mount Sinai Memorial Sloan Kettering Cancer Center New York University School of Medicine The Rockefeller University Weill Cornell Medical College Yale University


Creating a global community of scientists leading their generation in stem cell research

CURRENT INSTITUTIONS OF ALUMNI A*STAR, IMCB, Singapore Albert Einstein College of Medicine Angelini, Italy Bar-Ilan University, Israel Columbia University Dana Farber Cancer Institute Harvard University Icahn School of Medicine at Mount Sinai Institute of Biomedicine of Valencia, Spain Johns Hopkins University King Mongkut's University of Technology Thonburi, Thailand Ludwig Botzmann Institute, Austria Ludwig-Maximilians-University Munich, Germany Memorial Sloan Kettering Cancer Center National Institute of Biological Sciences, China New York Neural Stem Cell Institute Northwestern University Oregon Health & Science University Sidra Medical and Research Center, Qatar Soonchunhyang University, South Korea Tel Aviv University, Israel The Feinstein Institute for Biomedical Research The NYSCF Research Institute The Rockefeller University The San Raffaele Telethon Institute for Gene Therapy, Italy TiGenix, Spain University Medical Center Hamburg-Eppendorf, Germany University of Calgary, Canada University of Padova, Italy University of Palermo, Italy University of Pennsylvania University of Southern California University of Texas Health Science Center VUmc Cancer Center Amsterdam, The Netherlands Weill Cornell Medical College


IMPACT SINCE THE PROGRAM’S INCEPTION

59

60

OUTSTANDING FELLOWS SUPPORTED

50

NEWLY AWARDED FELLOWS

NUMBER OF FELLOWS

40

30

20

10

2006

2007

2008

2009

2010

2011

2012

2013

2014

2015

2016

2017

YEAR

Over

58%

OF ALUMNI ALREADY HOLD INDEPENDENT PROFESSORSHIPS

950

TOTAL PUBLICATIONS

98%

OF ALUMNI ARE ACTIVELY PURSUING THEIR SCIENTIFIC CAREERS


RESEARCH AREAS BY THE NUMBERS

3%

3% 25%

19%

STEM CELL RESEARCH AREAS

5%

9% 5%

98%

31%

AREAS OF STUDY

OF ALUMNI ARE ACTIVELY PURSUING THEIR SCIENTIFIC CAREERS

Autoimmune Diseases

Cancer & Blood Diseases

Cardiovascular Diseases

Diabetes

Liver Diseases

Neurodegenerative Diseases

Stem Cell Biology

Tissue Engineering


­­NYSCF INNOVATORS

Top row from left: Drs. Sjoukje van der Stegen and Gabsang Lee; Drs. Ying Liu, Sjoukje van der Stegen, Brett Shook, Alexandre Gaspar Maia, and Larry Luchsinger; Middle row from left: Drs. Elena Ezhkova, Tae Wan Kim, Ying Liu, Dominik Paquet, Alexandre Gaspar Maia, and Larry Luchsinger, Susan L. Solomon, CEO, NYSCF, Drs. Brett Shook, Hongda Li, Sjoukje van der Stegen, Panos Douvaras, Laura Andres-Martin; Bottom row from left: Dr. Panos Douvaras; Drs. Tae Wan Kim, Benjamin Lin, and Ying Liu


­­NYSCF LEADERSHIP BOARD OF DIRECTORS NYSCF’S Board of Directors are leaders in medicine, the arts, and business. Their talents and experience, combined with an unwavering commitment to advancing stem cell research, guide NYSCF in realizing its mission. Roy Geronemus, MD, Chairman Susan L. Solomon, CEO & Co-founder Margo Alexander Peggy Brim Bewkes Marilyn G. Breslow Karen E. Burke, MD, PhD Paul Goldberger George Lazarus, MD Richard J. Massey, PhD Paul M. Meister Stephen M. Ross Stephen M. Scherr Stuart Smith, DPhil Anita Volz Wien

LEADERSHIP COUNCIL NYSCF’S Leadership Council members are valued ambassadors who are committed to funding and promoting NYSCF’s mission to accelerate cures through stem cell research. Katherine Bristor and William Priest David A. Carmel Russell L. Carson Chuck Close Alan M. Cohen Shirley Cook Fiona and Stanley Druckenmiller Jodie and John Eastman Frank Gehry Lawrence E. Golub and Karen Finerman April Gornik Marlene Hess Tania Higgins

Dorothy Lichtenstein Sandra Lloyd Stephen Meringoff David Mitnick Nancy and Fred Poses Carol Roaman Julian Robertson Eric A. Rose, MD Andy Russell Alice Shure Barbara Stovall Smith Noelle and Dick Wolf

as of 5/19/2017


­­NYSCF INNOVATORS

NYSCF – Robertson Stem Cell Investigators • Maria Barna • Deepta Bhattacharya Kristen Brennand • Dieter Egli • Valentina Greco • Mitchell Guttman • Jacob Hanna • Justin Ichida Alexander Meissner • Malin Parmar • Jennifer E. Phillips-Cremins • Jay Rajagopal • Kristy Red-Horse Takanori Takebe • Feng Zhang • NYSCF – Robertson Neuroscience Investigators • Hillel Adesnik Edward Chang • Winrich Freiwald • Lisa Giocomo • Christopher Harvey • Daniel Huber Zachary Knight • Maria Lehtinen • Michael A. Long • Dragana Rogulja • Vanessa Ruta • Kay M. Tye Melissa Warden • Claire Wyart • Michael Yartsev • NYSCF – Robertson Investigator Alumni Paola Arlotta • Ed Boyden • Shuibing Chen • Christopher Gregg • Takaki Komiyama Gabsang Lee • Gaby Maimon • Ravi Majeti • Derrick Rossi • Paul Tesar • Marius Wernig NYSCF Research Institute Investigators • Valentina Fossati • Bjarki Johannesson • Aiqun Li Scott Noggle • NYSCF – Ralph Lauren Investigator • Giuseppe Maria de Peppo NYSCF – Helmsley Stem Cell Investigator Alumni • Valentina Fossati • Darja Marolt NYSCF – Druckenmiller Fellows • Laura Andres-Martin • Dafne Campigli Di Giammartino Tae Wan Kim • Hongda Li • Benjamin Lin • Raphael Lis • Ying Liu • Maria Maryanovich Sangbum Park • Brett Shook • Julia TCW • NYSCF – Druckenmiller Fellowship Alumni Sriram Bandi • Zhongwei Cao • Ting Chen • Elisa Cimetta • Dilek Colak • Francesco Paolo Di Giorgio Raffaella Di Micco • Bi-Sen Ding • Panos Douvaras • Dieter Egli • Samantha England • Elena Ezhkova Christopher Fasano • Nuria Flames • Valentina Fossati • Alexandre Gaspar Maia • Tamar Hermesh Ya-Chieh Hsu • Sarah Xuelian Huang • Justin Ichida • Keiichi Inoue • Daylon James Bjarki Johannesson • Natalie Kim • Evangelos Kiskinis • Fabien Lafaille • Dung-Fang Lee Gabsang Lee • Larry Luchsinger • Darja Marolt • Ian Martin • Maitane Ortiz-Virumbrales Dominik Paquet • Sandra Pinho • Christophe Raynaud • Pantelis Rompolas • Marco Seandel Jae-won Shim • Shivatra Noi Talchai • Wee-Wei Tee • Maya Tevlin • Maria Themeli Sjoukje van der Stegen • George Kai Wang • Yingying Zhang • Giovanni Zito • Oren Ziv NYSCF – Robertson Stem Cell Prize Recipients • Peter J. Coffey • Franziska Michor Kazutoshi Takahashi • Amy J. Wagers • Marius Wernig • Feng Zhang • NYSCF Research Institute Kennedy Agwamba • Lauren Bauer Vensand • Katie Brenner • Geoff Buckley-Herd • Sean DesMarteau Panos Douvaras • Patrick Fenton • Eliana Forero • Yosif Ganat • Jordan Goldberg Ya-Chu Juliana Hsu • Christopher Hunter • Tanya Jain • Travis Kroeker • Ilya Kruglikov • Gregory Lallos Sam Levy • Hector Martinez • Barry McCarthy • Paul McCoy • Rick Monsma • Dorota Moroziewicz Reid Otto • Daniel Paull • Brandon Pearl • Katie Reggio • Tomasz Rusielewicz • Ana Sevilla Martina Sladkova • Bruce Sun • Cecile Terrenoire • Michael Yaffe • Monica Zhou • Matthew Zimmer

The New York Stem Cell Foundation


www.nyscf.org

The NYSCF Fellowship Program  

The NYSCF Fellowship Program supports postdoctoral scientists at an early stage of their careers. These young researchers hold the potential...

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