NOBCChE 36th Annual Conference of NOBCChE | St. Louis, MO | April 13 - 15, 2009

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The 36th Annual Conference of The National Organization for the Professional Advancement of Black Chemists and Chemical Engineers

“NOBCChE ‘09 – The Perfect Gateway to STEM” St. Louis, Missouri



TABLE OF CONTENTS Welcome Letters Alfred P. Sloan Foundationʹs Minority Ph.D. Program

ii vii

Hotel Layout

x

Conference Sponsors

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Conference at a Glance NOBCChE Endowment Education Fund Program Schedule (Detailed) NOBCChE 2009 Career Expo Exhibitors Forum and Workshop Abstracts Conference Speakers Technical Abstracts Poster Session Abstracts National Conference Planning Committee National Conference Planning Committee Subcommittees

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Many backgrounds. Many cultures. Many perspectives.

One World. One Merck.

At Merck & Co., Inc. we embrace the individual differences each of us bring to the world. We believe that with the collective backgrounds, experiences and talents of our employees, anything can be conquered. It is those unique qualities that give us perspective to spark innovation and address unmet medical needs of people throughout the world. Our professional culture is one of diverse, collaborative and respectful individuals. Together we help deliver Merck medicines to those who need them, impacting lives all around the globe. If you’re ready to find your place in the world of Merck, learn more about us and see employee video profiles at merckcareers.jobs/nobcche.

JWT EC - St. Louis

I/O: NY86183 Client: Merck Media: NoBCChE Color: bw Size: 7.5 x 10 Date: 03.02.09 Artist: ll V: 1 PROOFING

Merck is an equal opportunity employer proudly embracing diversity in all of its manifestations.

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N BCChE

National Organization for the Professional Advancement of Black Chemists and Chemical Engineers ADMINISTRATIVE OFFICERS President Victor McCrary, Ph.D. Johns Hopkins University – APL Baltimore, MD Vice-President John Harkless, Ph.D. Howard University Washington, DC

Dear Conference Participants,

Secretary Sharon J. Barnes, MBA/HRM The Dow Chemical Company Port Lavaca, TX

On behalf of the Executive Committee, I welcome you to the 36th Annual Technology Conference of NOBCChE. Our host city, St. Louis, Missouri, the “Gateway to the West,” provides an apt theme for this year’s conference: The Perfect Gateway to STEM. Annually, this conference proves to be a full and exciting experience for students, faculty members, and scientist and engineers in industry. As we begin to meet President Barack Obama’s challenge to improve significantly the nation’s scientific education, invention, and production from elementary schools to graduate education, this conference seeks to surpass all previous meetings of black scientists and engineers This week will combine interesting scientific programs with the hospitality of the St. Louis Renaissance Grand Hotel and the city in what should be the most unforgettable scientific and social gathering of black chemists and engineers ever assembled. I hope that you will vigorously partake in the formal and informal panels and discussion that will ensue. The conference is designed to enhance the scientific and networking skills that will advance your academic and professional career.

Treasurer Lolita Grant, CPA Atlanta, GA National Student Representative Sean Gant University of Michigan Ann Arbor, MI Midwest Regional Chair Judson Haynes, Ph.D. The Procter and Gamble Company Mason, OH Northeast Regional Chair Tommie Royster, Ph.D. Eastman Kodak Company Rochester, NY Southeast Regional Chair James Grainger, Ph.D. Centers for Disease Control and Prevention Atlanta, GA Southwest Regional Chair Melvin Poulson Schering-Plough Animal Health Baton Rouge, LA West Regional Chair Isom Harrison Lawrence Livermore Natl. Lab Livermore, CA

EXECUTIVE COMMITTEE Bobby Wilson, Ph.D. Chairman Texas Southern University Houston, TX Perry Catchings, Sr. MS, MBA, Vice Chair Prime Organics, Inc. Woburn, MA Ella Davis, NOBCChE Executive Director Center Square, PA Ronald Lewis II, Ph.D. Member at Large Pfizer, Inc. La Jolla, CA Gloria T. MaGee, PhD, Member at Large Xavier University New Orleans, LA

With kind regards,

Bernice Green, Member at Large Spelman College Atlanta, GA Sandra Parker, National Planning Chair The Dow Chemical Company Dallas, TX

Bobby Wilson, Ph.D.

Isiah Warner, Ph.D., Member at Large Louisiana State University Baton Rouge, LA

P.O. Box 77040 Washington, DC 20013-77480 800-776-1419

www.nobcche.org


N BCChE National Organization for the Professional Advancement of Black Chemists and Chemical Engineers ADMINISTRATIVE OFFICERS President Victor McCrary, Ph.D. Johns Hopkins University – APL Baltimore, MD

April 2009 NOBCChE 2009 Annual Meeting Attendees, Welcome to St. Louis!!! The theme for this year’s Annual Meeting is “NOBCChE ’09 The Perfect Gateway to STEM”. This week in St. Louis we gather together to listen and to exchange ideas, and to celebrate the accomplishments of both our professional and student members. Our theme is timely, as the Obama Administration is emphasizing the need for new ideas and technological innovations. Science and technology, buttressed by sustained research and development is the fuel for our economic resurgence, and provides hope for a healthy global environment that will be available for future generations. A diverse pool of scientists and engineers ensures there will be a continued rich source of new ideas and intellectual prosperity. Remember, the mission of NOBCChE is creating an eminent cadre of people of color in science and technology. In keeping with our mission, we have attracted many high level and well-respected speakers for this year’s Annual Meeting (AM36), including: Dr. Mark Wrighton, Chancellor, Washington University in St Louis; Dr, Nathan Fletcher, President of the National Dental Association; Dr. Richard Davis, Head of the Mass Section at the Bureau International des Poids et Mesures in France; Dr. Levi Thompson, Associate Dean of Chemical Engineering at the University of Michigan; Dr Soni Oyekan, Reforming & Isomerization Technologist for Marathon Oil; Dr Squire Booker, Associate Professor and Pennsylvania State University. I invite you to attend our Grand Opening Business Section where we will discuss the State of the Organization and our vision “NOBCChE 2012: Creating the Cadre – Science for All Americans”. We will present a plan for NOBCChE for the next three years to become that gateway to the STEM disciplines. AM 36 features over 150 technical presentations; symposia in materials, biotechnology, health, and alternate energy; professional development seminars; our NOBCChE-HBCU National Panel; Career Fair Expo; Teacher’s Workshop; the NOBCChE National Science Fair & Science Bowl and much, much more. Thank you all, our attendees, sponsors, members, advocates, and friends for your continued support of NOBCChE and its mission. Please enjoy this year’s Annual Meeting, and we look forward to seeing you again in Atlanta in 2010!!! Best Always,

Vice-President John Harkless, Ph.D. Howard University Washington, DC Secretary Sharon J. Barnes, MBA/HRM The Dow Chemical Company Port Lavaca, TX Treasurer Lolita Grant, CPA Atlanta, GA National Student Representative Sean Gant University of Michigan Ann Arbor, MI Midwest Regional Chair Judson Haynes, Ph.D. The Procter and Gamble Company Mason, OH Northeast Regional Chair Tommie Royster, Ph.D. Eastman Kodak Company Rochester, NY Southeast Regional Chair James Grainger, Ph.D. Centers for Disease Control and Prevention Atlanta, GA Southwest Regional Chair Melvin Poulson Schering-Plough Animal Health Baton Rouge, LA West Regional Chair Isom Harrison Lawrence Livermore Natl. Lab Livermore, CA

EXECUTIVE COMMITTEE Bobby Wilson, Ph.D. Chairman Texas Southern University Houston, TX Perry Catchings, Sr. MS, MBA, Vice Chair Prime Organics, Inc. Woburn, MA Ella Davis, NOBCChE Executive Director Center Square, PA Ronald Lewis II, Ph.D. Member at Large Pfizer, Inc. La Jolla, CA Gloria T. MaGee, PhD, Member at Large Xavier University New Orleans, LA Bernice Green, Member at Large Spelman College Atlanta, GA

Victor M. McCrary, Ph.D. NOBCChE National President

Sandra Parker, National Planning Chair The Dow Chemical Company Dallas, TX Isiah Warner, Ph.D., Member at Large Louisiana State University Baton Rouge, LA

P.O. Box 77040 Washington, DC 20013-77480 800-776-1419

www.nobcche.org


N BCChE National Organization for the Professional Advancement of Black Chemists and Chemical Engineers ADMINISTRATIVE OFFICERS

Sandra K. Parker NOBCChE National Conference Chair

President Victor McCrary, Ph.D. Johns Hopkins Physics Labs Baltimore, MD Vice-President John Harkless, Ph.D. Howard University Washington, DC

It is with great anticipation that I welcome each of you to our 2009 national conference. I can say with confidence that we have something for everyone this year. Whether you’re a high school student or teacher, new graduate or working professional, this annual meeting will meet your expectations. We are excited to be here at the gateway to the west as we celebrate “NOBCChE 09 – The Gateway to STEM”. Each year it is our desire to incorporate your feedback into our program and look for ways to improve our national meeting. We are featuring several technical workshops and sessions that will focus on areas specific in Biotechnology, Nanotechnology and Alternate Energy Sources. We’ve worked hard to ensure that the entire St. Louis Community has an opportunity to come out and participate in our conference with our annual Health Symposium where we focus on Diabetes, a disease impacting a great number of African-Americans as well as our Career Expo, where several companies, academic institutions and organizations will be available to discuss career choices and job opportunities. It’s a chance for all attendees to meet future employers and mentors -- undergraduate/graduate students preparing to enter the workforce or seek higher education, professionals who are looking for career changes, and high school students finalizing college choices and validating their educational goals with science or engineering. Being prepared for this vulnerable economy is critical in today’s society. We exist primarily to support the process of preparing young people to excel academically and to pursue careers in science and technology. So, we thank all the registrants, sponsors and supporters of NOBCChE for making this conference a reality. St. Louis, a city where it’s All Within Reach provides a wonderful backdrop for us to come together to commit to improving the skills we possess and forwarding the chemical profession. Enjoy the conference!

Secretary Sharon J. Barnes, MBA/HRM The Dow Chemical Company Seadrift, TX Treasurer Lolita Grant, CPA. Atlanta, GA National Student Representative Sean Gant University of Michigan Ann Arbor, MI Midwest Regional Chair Judson Haynes, Ph.D. The Procter and Gamble Company Mason, OH Northeast Regional Chair Tommie Royster, Ph.D. Eastman Kodak Company Rochester, NY Southeast Regional Chair James Grainger, Ph.D. Centers for Disease Control and Prevention Atlanta, GA Southwest Regional Chair Melvin Poulson Schering-Plough Animal Health Baton Rouge, LA West Regional Chair Isom Harrison Lawrence Livermore Natl. Lab Livermore, CA

EXECUTIVE COMMITTEE Bobby Wilson, Ph.D. Chairman Texas Southern University Houston, TX Perry Catchings, Sr. MS, MBA, Vice Chair Prime Organics, Inc. Woburn, MA Ella Davis, NOBCChE Executive Director Center Square, PA Sandra Parker, National Planning Chair The Dow Chemical Company Dallas, TX Ronald Lewis II, Ph.D. Member at Large Pfizer, Inc. La Jolla, CA

Sincerely,

Gloria T. MaGee, PhD, Member at Large Xavier University New Orleans, LA

Sandra K. Parker

Bernice Green, Member at Large Spelman College Atlanta, GA

Sandra K. Parker 2009 Conference Chair

Isiah Warner, Ph.D., Member at Large Louisiana State University Baton Rouge, LA

P.O. Box 77040 Washington, DC 20013

www.nobcche.org

800-776-1419


N BCChE National Organization for the Professional Advancement of Black Chemists and Chemical Engineers ADMINISTRATIVE OFFICERS President Victor McCrary, Ph.D. Johns Hopkins Physics Labs Baltimore, MD

Dear Colleagues -

Vice-President John Harkless, Ph.D. Howard University Washington, DC

On behalf of the Midwest NOBCChE Region, I am delighted to welcome you to the 2009 NOBCChE National Conference in St. Louis, Missouri. We are proud to continue this tradition of the Annual NOBCChE Conference for our members! This year, we are delighted to be hosting the conference for the first time in St. Louis, Missouri. With this move, we hope to expand the appeal of the Conference to a wider audience, including more professionals and students from schools across the country.

Secretary Sharon J. Barnes, MBA/HRM The Dow Chemical Company Seadrift, TX Treasurer Lolita Grant, CPA. Atlanta, GA National Student Representative Sean Gant University of Michigan Ann Arbor, MI

In line with our vision of building a cadre of eminent Chemists and Chemical Engineers, we are pleased to offer a rich content of insightful keynote speakers, technical talks, educational panels and science bowl competitions. This year's theme, "NOBCChE ’09: The Perfect Gateway to STEM", will address the changing face of Science and Technology. We are confident that the myriad of scientific and instructional presentations will appeal to participants of diverse backgrounds and interests. The Conference brings together an unprecedented range and caliber of participants, offering a unique opportunity for attendees to socialize, network and exchange ideas with peers from across the Chemical and Chemical Engineering fields. We hope that this will be a rewarding occasion for all.

Midwest Regional Chair Judson Haynes, Ph.D. The Procter and Gamble Company Mason, OH Northeast Regional Chair Tommie Royster, Ph.D. Eastman Kodak Company Rochester, NY Southeast Regional Chair James Grainger, Ph.D. Centers for Disease Control and Prevention Atlanta, GA Southwest Regional Chair Melvin Poulson Schering-Plough Animal Health Baton Rouge, LA West Regional Chair Isom Harrison Lawrence Livermore Natl. Lab Livermore, CA

EXECUTIVE COMMITTEE

We are honored that distinguished speakers, panelists, moderators, faculty and staff have agreed to participate in the Conference, and we thank them for their invaluable contributions. I would also like to thank the conference executive committee, Regional Chairs, Chapter Presidents and numerous volunteers for their exceptional dedication and hard work. Finally, I would like to thank our Sponsors, without whom we would be unable to achieve our ambition of making this the finest NOBCCHE Conference to date.

Bobby Wilson, Ph.D. Chairman Texas Southern University Houston, TX Perry Catchings, Sr. MS, MBA, Vice Chair Prime Organics, Inc. Woburn, MA Ella Davis, NOBCChE Executive Director Center Square, PA Sandra Parker, National Planning Chair The Dow Chemical Company Dallas, TX

Sincerely,

Ronald Lewis II, Ph.D. Member at Large Pfizer, Inc. La Jolla, CA

Dr. Judson Haynes III

Gloria T. MaGee, PhD, Member at Large Xavier University New Orleans, LA

Midwest Regional Chair

Bernice Green, Member at Large Spelman College Atlanta, GA Isiah Warner, Ph.D., Member at Large Louisiana State University Baton Rouge, LA

P.O. Box 77040 Washington, DC 20013

www.nobcche.org

800-776-1419


Alfred P. Sloan Foundationʹs Minority Ph.D. Program

The Chemistry Department of the University of California, Davis The Ph.D. component of the Alfred P. Sloan Foundationʹs Minority Ph.D. Program provides substantial scholarship support to underrepresented minority students who are beginning their doctoral work in engineering, natural science and mathematics. There are forty‐six universities in this program and ten of them are in chemistry. The chemistry department of the University of California, Davis (UCD) joined the program in 2002 and like all of them its acceptance was based in part on its past performance in producing minority students in the field. At the time of our acceptance in the program UCD’s chemistry department had awarded 9 PhD and 2 MS degrees to African American students and 6 PhD and one MS degrees to Hispanics students over the previous 15 years. The average number of minority students accepted per year in the program was 1.86 students/year. Over the same period of time the overall retention rate (number graduated/number graduated + those that left) was 82.3%. We currently have 18 Sloan Fellows (seven African American, ten Hispanic and one Native American) out of a population of 31 domestic minority students. That means that 58% of our minority students are Sloan Scholars. Two of the six non‐Sloan Fellows (one Native American female and one African American female) have “Bridge to the Doctorate” Fellowships funded by NSF. With our population of 231 students 10.4 % are minority students and our 4 international students of color would raise this to 12.1 %. In the past six years, the Alfred P. Sloan Foundation has provided $ 534,000 in support for minority PhD students in Chemistry. In that time we have graduated 4 PhDs: Dr.’s Michael Varela (2007), Latasha Lamotte (2008), Erica McJimpsey (2008) and Jimmy Franco (2008). The Alfred P. Sloan Minority PhD Program works slightly differently at UCD than it does at other institutions. Our program is based upon the proposition that all UCD PhD graduate students are to be supported by the department and their Major Professor. Thus, all of our students are guaranteed the same financial support. The current support includes a stipend of $24,000/year, plus payment of in‐state and health fess of $10,618 and an additional $14,694 for non‐resident fees if the student is not a California resident. The financial offer amounts to a total of $34,618 for California residents and $49,312 for non‐ California residents. The Alfred P. Sloan grant is a one‐time augmentation of up to $32,000 that can be used by the student over their graduate career at the University. The fact that the Sloan students receive the same base support of all graduate students is important because it recognizes the accomplishments of these students in their previous career. We are recognizing that any minority student who is accepted in our regular graduate program is truly unique given the fact that very few minorities achieve this level of success in chemistry. Those students who then get Sloan grants are even more exceptional because they are the best of those that are accepted.


Alfred P. Sloan Foundationʹs Minority Ph.D. Program Our insistence that the major professors use their own funds to support the Sloan student is important for the student in two ways. It insures that the Major professors have the same personal stake in the success of the Sloan students as they have in all of their students because it is tied to their own professional success. From the student’s point of view, they know that their continuing support in graduate school depends upon them working with their advisor like it does for all graduate students. They cannot then go their own way without consultation and support of their major professor. The Sloan funds that are supplied to the student can be used for a variety of purposes. When a student enters graduate school to obtain a PhD in chemistry is, on average, a five‐ year commitment. The base funding that is supplied by the universities is really only enough for the basic needs of the student. It is not designed for emergencies, or for the initial establishment of residency in a new place. The Sloan funds can be used to help ease the student’s transition from undergraduate to graduate school. They can be used to pay for moving expenses, computer support, travel for research, and emergencies that often arrive in any student’s life. All of the requests for funds have to be approved by their principal investigator (PI) before they are submitted to NACME (National Action Council for Minorities in Engineering) for payment. The PI also has to review the annual report of the students, which is one ways that the PI gets a chance to have a detailed discussion about the progress of the students. The academic progress of each of the students is reviewed on a regular basis to determine if they are progressing at a normal rate toward the degree. If not, every effort is made to provide any help that can be obtained to address the difficulties they may be having. In some cases this can involve tutoring on a particular subject or pointing them to a place where they can obtain the help that they may need. Many of our present and former African American students were recruited at the annual NOBCCHE conference or by contacts with their professors attending the conference. This is one reason that we have been able to meet the goals for recruiting the students in the program. The PI has also traveled to many HBCU chemistry departments to recruit some of the students that we have in the program. The success of the program at UC Davis depends upon many people in the chemistry department and the university. Special recognition has to be given to the students’ major professors and their commitment to the program as well as to Ms. Carol Barnes who is in charge of the Graduate Affairs program in the department.


HOTEL LAYOUT

Meeting Room Location Summary Room # Landmark 1 – 7 Pershing Kingsbury Lindell Benton Parkview

Portland Aubert Lafayette

Crystal Ballroom* Landmark Ballroom

Rooms 200 ‐ 229 Hall 1

Building Renaissance Hotel Renaissance Hotel Renaissance Hotel Renaissance Hotel Renaissance Hotel Renaissance Hotel Renaissance Hotel Renaissance Hotel Renaissance Hotel Renaissance Hotel Renaissance Hotel Convention Center+ Convention Center

Level Level One Level One Level One Level One Mezzane Level Mezzane Level Mezzane Level Mezzane Level Mezzane Level Twenty First Floor Level One Level Two Level One

*Take the express elevators to 21st floor. + Exit via the Washington Avenue entrance and cross the street to the Convention Center.


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Convention Center Level 1

Career Fair Expo Across Washington Avenue from Renaissance Hotel


HOTEL LAYOUT

Convention Center Level 2

Thursday: Science Fair and Bowl Competitions Rooms


CONFERENCE SPONSORS

Our Sponsors THANK You for Contributing to the Overall Success of our conference – we salute you! ********

3M American Association for the Advancement of Science (AAAS) Agilent Technologies American Chemical Society Atlanta Metropolitan Chapter – NOBCChE Bayer Material Science Boehringer Ingelheim Brazoria County Area Chapther – NOBCChE Claflin University Colgate‐Palmolive Company

Committee for Action Program Services (CAPS) 1


CONFERENCE SPONSORS Committee on the Advancement of Women Chemists (COACh) The Dow Chemical Company Dupont Eastman Kodak Company Eli Lilly & Company Florida A&M University – Science Institute GlaxoSmithKline The Johns Hopkins University – Applied Physics Laboratory The Lubrizol Corporation MIT Chemistry & Chemical Engineering Northeast Section – American Chemical Society National Research Council of the National Academies National institute of Standards & Technologies (NIST)

2


CONFERENCE SPONSORS National Masinet Management Office Procter & Gamble Roche Texas Southern University Washington University in St. Louis

3


CONFERENCE AT A GLANCE Date

Description

Day /Time Sunday, April 12

Room Event

Room Location

Conference Registration

4:00 p.m. ‐ 6:00 p.m.

Landmark Foyer/Reg Office

Monday, April 13

7:30 a.m. ‐ 4:00 p.m.

Conference Registration

Landmark Foyer/Reg Office

7:30 a.m. ‐ 8:00 a.m.

NPC Committee Meeting

Lafayette

8:00 a.m. ‐‐ 10:00 a.m.

NOBCChE Executive Board Meeting

Pershing/Lindell

10:45 a.m. ‐ 11:45 a.m

Henry Hill Lecture Speaker Dr. Richard Davis, Head, Bureau International des Poids et Mesures Mass Section, Lyon, France, “Redefining the Kilogram Through a Fundamental Constant.” Sponsored by Northeast Section of ACS and MIT Chemistry Department

Landmark 6‐7

.

12:00 p.m. ‐ 1:30 p.m.

Opening Luncheon (ticketed) –

Landmark 1‐4

Guest Speaker: Chancllor Mark Wrighton sponsored by Washington University in St. Louis

1:45 p.m. ‐ 2:45 p.m.

Grand Opening Business Session

Landmark 6‐7

1:45 p.m. ‐ 5:30 p.m.

COACH Workshop ‐ registration required

Lindell

4


CONFERENCE AT A GLANCE 3:00 p.m. ‐ 4:00 p.m.

Plenary 1 New Developments in Dentistry Materials

Landmark 6‐7

4:00 p.m. ‐ 6:00 p.m..

Technical Session 1: Lloyd L. Ferguson Award Symposium: Materials Chemistry

Landmark 6‐7

4:00 p.m. ‐ 6:00 p.m.

Technical Session 2: Bio‐Environmental Chemistry

Portland

Opening Reception

Crystal

. 6:00 p.m. ‐ 8:00 p.m. Tuesday, April 14 7:15 a.m. ‐ 7:45 a.m.

NPC Committee Meeting

Lafayette

7:00 a.m. ‐ 5:00 p.m.

Teacherʹs Workshop I

8:00 a.m. ‐ 4:00 p.m.

Conference Registration

Landmark 5 Landmark Foyer/Reg Office

8:30 a.m. ‐ 9:30 a.m.

Plenary II ‐ Biotechnology

Portland/Benton

9:45 a.m. ‐ 11:45 a.m.

Corning Technical Sessions Technical Session 3: Biochemistry/Biotechnology I

Portland/Benton

9:45 a.m. ‐ 11:45 a.m.

Technical Session 4: Physical Chemistry

Parkview

9:45 a.m. ‐ 11:45 a.m.

Technical Session 5: Henry McBay Outstanding Teacher Symposium ‐ STEM Education

Aubert

12:00 p.m. ‐ 1:30 p.m. Percy Julian Symposium & Luncheon Landmark 1‐4 (ticketed) Speaker: Dr. Soni Oyekan, Reforming & Isomerization Technologist, Marathon Oil sponsored by Corning, Inc.

5


CONFERENCE AT A GLANCE The Johns Hopkins University Applied Physics Laboratory Technical Sessions 1:45 p.m. ‐ 3:45 p.m.

1:45 p.m. ‐ 3:30 p.m.

Technical 6: Biochemistry/Biotechnology II Technical 7: Graduate Student Fellowship Award Sci‐Mix Forensic Workshop

3:30 p.m. ‐ 4:30 p.m.

Exhibitors Meeting

4:00 p.m. ‐ 6:00 p.m.

Plenary III ‐ Health Symposium sponsored by Eli Lilly Company

Landmark 6‐7

6:00 p.m. ‐ 8:00 p.m.

Exhibitorʹs Welcome Reception

Convention Center, Room 221

Wednesday, April 15

Student Planning Meeting

Convention Center, Room 200

1:45 p.m. ‐ 3:45 p.m.

7:00 a.m. ‐ 7:30 a.m. 7:15 a.m. ‐ 7:45 a.m.

Portland/Benton Aubert Pershing Convention Center, Room 221

NPC Committee Meeting

Lafayette

7:00 a.m. ‐ 5:00 p.m.

Teacherʹs Workshop II

9:00 a.m. ‐ 4:00 p.m.

Conference Registration

9:00 a.m. ‐ 6:00 p.m.

CAREER FAIR EXPO

Landmark 5 Landmark Foyer/Reg Office Hall 1, Convention Center

9:00 a.m. ‐‐ 10:30 a.m.

Professional Development Workshop NSF Graduate Research Fellowship Informational Session

Pershing/Lindell

9:00 a.m. ‐ 11:00 a.m.

Professional Development Workshop Utilizing The STAR

Kingsbury

9:00 a.m. ‐ 11:00 a.m.

Professional Development Workshop Academia: What Are your Options (pt 1)

Benton

6


CONFERENCE AT A GLANCE 10:00 a.m. ‐ 11:30 a.m.

11:15 a.m. ‐ 12:15 p.m.

12:00 p.m. ‐ 1:00 p.m.

1:00 p.m. ‐ 3:00 p.m.

Professional Development Workshop ACS: Managing An Effective Job Search (pt Parkview 1) Professional Development Workshop Landmark 6 “Lets Talk Graduate School” Convention LUNCH ON YOUR OWN Center Professional Development Workshop ʺUtilizing The STARʺ Guest Speaker ‐ Carolyn Greco

Kingsbury

1:00 p.m. ‐ 5:00 p.m.

Poster Setup for Science Fair

Convention Center Room 221

1:00 p.m. ‐ 4:30 p.m.

Professional Development Workshop ACS: Managing An Effective Job Search (pt 1 &2)

Parkview

1:30 p.m. ‐ 3:30 p.m.

Professional Development Workshop “How To Find A Jobʺ, Nick Nikolaides, Ph.D., Manager, Doctoral Recruiting & University Relations, The Procter & Gamble Company

1:00 p.m. ‐‐ 5:00 p.m.

Poster setup for students

1:00 p.m. ‐‐ 5:00 p.m.

National Science Competition Registration

4:00 p.m. ‐ 5:00 p.m. 5:30 p.m. ‐ 9:30 p.m. 4:00 p.m. ‐ 6:00 p.m.

Science Bowl/Fair Volunteers’ Meeting Science Competition Registration Opening Meeting 7

Portland

Convention Center Room 228 and 229 Landmark 5&6 Convention Center, Room 223 and 221 Landmark 5&6 Hall 1,


CONFERENCE AT A GLANCE

NOBCChE Scientific Exchange Poster Session

8:00 p.m. ‐ 9:00 p.m.

Science Fair Poster setup

Convention Center Convention Center Room 228 & 229

Thursday, April 16

7:15 a.m. ‐ 7:45 a.m.

NPC Committee Meeting

7:30 a.m. ‐ 9:30 a.m.

Science Fair Judging

8:00 a.m. ‐ 8:30 a.m.

Student Planning Meeting

8:00 a.m. ‐ 4:00 p.m.

9:30 a.m. ‐‐ 12:00 p.m.

Conference Registration Science Bowl Competitions: Junior Division++ sponsored by Agilent Technologies and ACS Department of Diversity Programs Plenary V: Alternate Energy Solutions Plenary sponsored by The Johns Hopkins Applied Physics Laboratory” Technical Session 8: Alternative Energy Solutions Academia: What Are your Options (pt 2) ‐ Gregory Tew Technical Session 9: Analytical Chemistry I

Lafayette Convention Center Room 228 and 229 Convention Center, Room 200 Landmark Foyer/Reg Office Convention Center Room 222, 223, 224

10:00 a.m. ‐‐ 5:00 p.m.

Science Fair Public Viewing

10:00 a.m. ‐ 12:00 p.m.

Rohm and Haas Competition Pershing/Lindell NOBCChE HBCU Panel “Increasing STEM Institutional Capacity: HBCU/HSI Strategic Aubert Alliances”

10:00 a.m. ‐ 12:30 p.m.

8:00 a.m. ‐‐ 9:00 a.m. 9:00 a.m. ‐ 12:00 p.m. 9:00 a.m. ‐ 11:00 a.m.

10:00 a.m. ‐‐ 12:00 p.m.

8

Portland/Benton Portland/Benton Kingsbury Parkview Convention Center Room 228 & 229


CONFERENCE AT A GLANCE 1:00 p.m. ‐ 5:00 p.m. 1:00 p.m. ‐ 3:30 p.m. 1:00 p.m. ‐ 5:00 p.m.

Science Bowl Competitions: Senior Division++ sponsored by Agilent Technologies and ACS Department of Diversity Programs Milligan Symposium Technical Session 10: Analytical Chemistry II

Convention Center Room 222, 223, 224 Pershing/Lindell Portland/Benton

1:30 p.m. ‐ 2:30 p.m.

Local Chapter Presidents Meetings (required)

Aubert, Parkview, Kingsbury, Lucas, Hawthorne

2:30 p.m. ‐ 3:30 p.m.

“GEM Workshop‐ Why Graduate School?”

Kingsbury

3:00 p.m. ‐ 5:00 p.m.

Technical Session 11: Organic Chemistry

Aubert

3:00 p.m. ‐ 5:00 p.m.

Technical Session 12: Professional Chemical Engineer Award Symposium

Parkview

5:00 p.m. ‐‐ 6:00 p.m.

Science Fair Poster Removal

7:00 p.m. ‐‐ 10:00 p.m.

Student Dinner/Activity Plenary VII Awards Ceremony & Gala Dinner (ticketed)

7:30 pm. ‐ 10:30 p.m.

Convention Center, Room 228 & 229 Convention Center, Room 220 and 229 Landmark Ballroom

Friday, April 17

8:00 a.m. ‐ 11:45 a.m.

Science Bowl Finals ‐ Junior/Senior Division Science Competition Awards Luncheon ticketed

Portland/Benton Crystal Ballroom

Science Competition Educational Trip

St. Louis Science Center

12:00 p.m. ‐ 2:00 p.m.

4:00 p.m. ‐ 7:00 p.m.

9


NOBCChE ENDOWMENT EDUCATION FUND

We wish to thank members and friends of the National Organization for the Professional Advancement of Black Chemists and Chemical Engineers for their support and confidence in the future of NOBCChE by making a $500.00 or more tax deductible contribution to the NOBCChE Endowment Education Fund. Mildred Allison Denise Barnes Iona Black* Henry T. Brown Winifred Burks‐Houck Virlyn Burse* Joseph N. Cannon Callista Chukwunenye Robert L. Countryman Andrew Crowe* Darrell Davis Anthony L. Dent* Lawrence E. Doolin* Linneaus Dorman* Fannie Posey Eddy James Evans, Sr. Lloyd Ferguson Lonnie Fogel Lloyd Freeman Eddie Gay Joseph Gordon* William Guillory* Jonathan K. Hale James Harris Bruce Harris* Ivory Herbert Kenneth W Hicks Neville Holder Isaac B. Horton, III Donald A. Hudson Charles R. Hurt

William M. Jackson* Madeleine Jacobs* Christopher Kinard Anita Osborne‐Lee George Lester, Jr. William A Lester, Jr. Mallinkrodt Chemical Inc. Willie May Jefferson McCowan* Victor McCrary Sidney McNairy Lynn Melton Philip Merchant Reginald E. Mitchell William V. Ormond* James A. Porter Cordelia M. Price* Marquita Qualls* Janet B. Reid Leonard E. Small* Florence P. Smith Michael Stallings* Clarence Tucker* Benjamin Wallace* Charles Washington Joseph Watson Billy Williams Keith B. Williams Reginald Willingham Bobby Wilson Andrea Young*

* Contributed more than $500.00

10


NOBCChE ENDOWMENT EDUCATION FUND

We wish to thank members and friends of the National Organization for the Professional Advancement of Black Chemists and Chemical Engineers for their support and confidence in the future of NOBCChE, and for their tax deductible contribution to the NOBCChE Endowment Education Fund.

Adegboye Adeyeno Keith Alexander Verlinda Allen Eugene Alsandor Roseanne Anderson Victor Atiemo‐Obeng Benny Askew, Jr. Joseph Barnes Sharon Barnes Tegwyn L. Berry Alfred Bishop Jeanette E. Brown Nora Butler‐Briant James Burke Jacqueline Calhoun Lashanda Carter Perry Catchings, Jr. Aldene Chambles John J. Chapman Esteban Chornet Reginald A. Christy Regina V. Clark James Clifton Edward Coleman George Collins James E. Cotton Garry S. Crosson Reuben Daniel Kowetha Davidson Ella Davis Thomas Davis Thomas Dill Gerald Ellis Lisa Batiste‐Evans Pat Fagbayi

Edward Flabe Edward E. Flagg Joe Franklin Russell Franklin Issac Gamwo John W. Garner Cornelia Gilyard Robert Gooden Warren E. Gooden Valerie Goss Etta Gravely Bernice Green Garry Grossman Keith V. Guinn Everett B. Guthrie Gene S. Hall James Hamilton Kinesha Harris April Harrison Isom Harrison Rogers E. Harry‐Oruru Lincoln Hawkins Ronald Haynes Ronald L. Henry Leonard Holley Sydana R. Hollins Smallwood Holoman, Jr. Brenda S. Holmes Nikisha Hunter Bernard Jackson Donald Jackson Evelyn P. Jackson Kim Jackson Kyle Jackson Raymond James 11

Ganiyua Jaiyeola Allene Johnson Elijah Johnson Harry Johnson Paula Johnson Saphronia Johnson Emmett Jones Evy Jones Jennifer A. Jones Jesse Jones Timothy Jones Thomas C. Jones Verlinda Jordan Jimmie Julian Ella L. Kelly Otis Kems Kirby Kirksey Rachel Law Mia Laws Lester A. Lee Cynthia R. Leslie Steve Lucas Alex Maasa Dale Mack George S. Mack Robert McAllister Aliecia McClain Gerald McCloud Jefferson McCowan Walter McFall Saundra Y. McGuire Dawn McLaurin Linda Mead‐Tollin Janice Meeks Charles W. Merideth


NOBCChE ENDOWMENT EDUCATION FUND M. P. Moon Damon Mitchell Robert Murff Harvey Myers Tina Newsome James Nichols Kenneth Norton Bunmi Ogunkeye Steven B Ogunwumi Mobolaji O. Olwinde Kofi Oppong Beverly Paul James Pearce James Pearson Tony L. Perry Howard Peters Mwita V Phelps Walter G. Phillips Louis Pierce Sonya Caston Pierre Wendell Plain Charles A. Plinton Melvin Poulson Jamacia Prince

Daniel Reuben Mary Robinson Press Robinson Anne Roby Tommie Royster Albert E Russell Franklin Russell Clark Scales Billy Scott Melva Scott Robert Shepard James P Shoffner Keroline M. Simmonds Tiffany Simpson Milton Sloan Karen Speights ‐ Diggs Oreoluwa Sofekun Lucius Stephenson Wilford Stewart Grant St. Julian Richard Sullivan Albert Thompson Dameyun Thompson

12

Ezra Totton Jorge Valdes Grant Venerable Cheryl A. Vocking Emmanuel Waddell Samuel von Winbush Gerald Walker Leon C. Warner Michael Washington Odiest Washington Ben Watson Joseph W. Watson Helen P. White Ronald H. White Thomas Whitt Leonard Wilmen Harold Lloyd Williams Laura C. Williams Joe Williams Raymond Williams Jeremy Willis Sean Wright Sandra Wyatt


PROGRAM SCHEDULE DAY OF WEEK

EVENT

Sunday

ROOM

April 12

Conference Registration

4:00 p.m. ‐ 6:00 p.m.

Landmark Foyer/Reg Office

Monday, April 13

7:30 a.m. ‐ 4:00 p.m.

Conference Registration

Landmark Foyer/Reg Office

7:30 a.m. ‐ 8:00 a.m.

NPC Committee Meeting

Lafayette

8:00 a.m. ‐‐ 10:00 a.m.

NOBCChE Executive Board Meeting

Pershing/Lindell

Henry Hill Lecture

Monday, a.m.

Landmark 6‐7. .

10:45 a.m. ‐ 11:45 a.m

Speaker – Dr. Richard Davis, Head, Bureau International des Poids et Mesures Mass Section, Lyon, France “Redefining the Kilogram Through a Fundamental Constant.” Sponsored by Northeast Section of ACS and MIT Chemistry Department

Monday, p.m.

Luncheon Speaker

Opening Luncheon 12:00 p.m. ‐ 1:30 p.m. (ticketed) Dr. Mark S. Wrighton, Chancellor Washington University in St. Louis

13

Landmark 5.


PROGRAM SCHEDULE Monday, p.m.

Welcome

Grand Opening Business Session Landmark 6‐7….. 1:45 p.m. ‐ 2:45 p.m. Ms. Sandra Parker, National Conference Chair

Greetings From The City St Louis City Officials

Executive Board Dr. Bobby Wilson, Chairman of National Executive Board State of the Dr. Victor R. McCrary, NOBCChE President . Organization Ms. Lolita Grant, Treasurer Financial Overview Election Results Mr. Perry Catchings, Elections Chair Closing Remarks & Ms. Sandra Parker, National Conference Chair . Announcements

Monday, p.m.

Monday, p.m.

COACH Workshop ‐ registration required 1:45 p.m. ‐ 5:30 p.m. “The Chemistry of Leadership” Presented by Sandra Shullman

Plenary 1 3:00 p.m. ‐ 4:00 p.m. New Developments in Dentistry Materials Dr. Nathan Fletcher, President of the National Dental Association

14

Lindell

Landmark 6‐7


PROGRAM SCHEDULE Monday, p.m.

Technical Session 1 4:00 – 6:00 p.m. Lloyd L. Ferguson Young Scientist Award Symposium: Landmark 6‐7 Materials Chemistry (ʺTitle,ʺ Presenter, Co‐Author(s), Affiliation) Session Chair: Sibrina Collins, Ph.D., The College of Wooster

4:15 p.m. – 4:55 p.m.

Lloyd L. Ferguson Young Scientist Award Winner “Synthesis Of Novel Conjugated Polymers Based On Benzobisoxazoles” Jared F. Mike, Andrew J. Makowski and Malika Jeffries‐EL* Department of Chemistry, Iowa State University, Ames IA 50011

4:55 p.m. – 5:15 p.m.

“Novel Precursor Design For The MOCVD Of Metal Oxides And Metal Nitrides” Felicia A. McClary, Jason S. Matthews* Howard University, Department of Chemistry, Washington DC, 20059, USA “Renewable Biomass Derived Polyolefins” Rennisha R. Wickham, Jia Wei, Lawrence R. Sita* Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742 “Crystal Engineering Of Metal‐Organic Frameworks” Sibrina N. Collins 1*, Roland Falcon1, Jeanette A. Krause 2,3, and William Connick2 1College of Wooster, Department of Chemistry, Wooster, OH 44691 2University of Cincinnati, Department of Chemistry, Cincinnati, OH 45221 3Richard C. Elder X‐ray Crystallography Facility, University of Cincinnati, Cincinnati, OH 45221

5:15 p.m. – 5:35 p.m.

5:35 p.m. – 6:00 p.m.

15


PROGRAM SCHEDULE Technical Session 2 4:00 – 6:00 p.m. Bio‐Environmental Chemistry (ʺTitle,ʺ Presenter, Co‐Author(s), Affiliation) Session Chair: Murphy Keller, Ph.D., U.S. DOE

Monday, p.m.

Portland

4:00 p.m. – 4:20 p.m.

4:20 p.m. – 4:40 p.m.

4:40 p.m. – 5:00 p.m.

5:00 p.m. – 5:20 p.m.

“Pharmacological Properties Of Plants Traditionally Used As Anti‐ Infectives And For Wound Healing” Hamilton, Allison, Moshi, Mainen, M.D., Innocent, Ester Ph.D., Masimba, Pax, PhD, Lynes, Maria, Meachem, Katrina. Minority Health International Research Training; Department of Chemistry, Hampton University Hampton, VA 23668, Summer 2008. “Milby Park Community: Potential Exposure To Elevated Levels Of 1,3‐ Butadiene May Cause Higher Risks For Developing Adverse Biological Effects” Natalie Roberts, Dr. Renard Thomas*, Dr. Bobby Wilson, Dr. John Sapp, and Dr. Andrew James Texas Southern University, College of Science and Technology, Department of Chemistry, Doctor of Philosophy Program in Environmental Toxicology, Houston, TX, 77004 “Transformation Of Fluorotelomer‐Based Surfactants In Pure Fungal Cultures And Aerobic Soils” Laurel A. Royer* and Linda S. Lee Department of Agronomy, Crop, Soil and Environmental Sciences, Purdue University, West Lafayette, IN 47907 “An Investigation Of Arsenic Compounds In Marine Samples” Filomena Califano*1, Dr. Kathleen Nolan2 1Dept. of Chemistry & Physics, St. Francis College, Brooklyn, NY, 11201 2 Dept. of Bilogy and Health Promotion, St. Francis College, Brooklyn, NY,

5:20 p.m. – 5:40 p.m.

11201 “Formation of PCDD/Fs from the Copper Oxide Surface‐Mediated Reactions of 1,2‐Dichlorobenzene under Pyrolytic Conditions” Shadrack Nganai, Slawomir Lomnicki, Barry Dellinger Louisiana State University, Chemistry Department Baton Rouge, LA 16


PROGRAM SCHEDULE 5:40 p.m. – 6:00 p.m.

“Induced Fluorescence Enhancement: A Method For Identifying Bacterial Species” Marlon Thomas, Elizabeth Zielins and Valentine I. Vullev* Department of Bioengineering, University of California, Riverside, CA 92521

Monday, p.m.

Reception 6:00 p.m. ‐ 8:00 p.m.

Crystal

Tuesday, April 14 7:15 a.m. ‐ 7:45 a.m.

NPC Committee Meeting

Lafayette

Teachers Workshop I 7:00 a.m. ‐ 5:00 p.m. Landmark 5 “Teachersʹ Embracing Science through Education”

Tuesday, a.m.

Sponsored by 3M, AAAS, and Committee for Action Program Services

Moderator

Mrs. Linda Davis, Committee Action Program Services Cedar Hill, TX

8:00 a.m.. – 8:45 a..m. 8:00 a.m.. – 8:45 a..m. 8:45 a.m. ‐ 9:00 a.m.

Registration Continential Breakfast Welcome and Opening Remarks Mrs. Linda Davis, Director, Committee Chairperson and Moderator Dr. Victor McCrary, President National NOBCChE

9:00 A.M. ‐ 12:00 N

ʺInspire Students to Excel at Science by Unveiling the Learning Process!ʺ

10:00 A.M. – 10:15 A.M.

Dr. Saundra McGuire, Director of Center for Academic Success, Adjunct Professor of Chemistry, and Associate Dean of University College at Louisiana State University, Baton Rouge, LA Break 17


PROGRAM SCHEDULE 12:00 N – 1:00 p.m. 1:00 p.m. – 3:30 p.m.

8:00 a.m. ‐ 4:00 p.m.

Tuesday, a.m.

Lunch “Integrating Tools for hands‐on teaching in the Classroom ‐ K‐12” Ms. Yolanda S. George, Deputy Director and Program Director American Association for the Advancement of Science (AAAS) Washington, DC Landmark Conference Registration Foyer/Reg Office

Plenary II ‐ Biotechnology 8:30 a.m. ‐ 9:30 a.m.

Portland/Benton

“Taking A Hit For The Team: Self‐Sacrifice As An Enzymatic Strategy In The Biosynthesis Of Lipoic Acid” Keynote Speaker: Dr. Squire Booker, Associate Professor, Pennsylvania State University

Corning Technical Sessions Tuesday, a.m.

Technical Session 3 9:45 – 11:45 a.m. Biotechnology and Biochemistry Applications I (ʺTitle,ʺ Presenter, Co‐Author(s), Affiliation) Session Chair: Alexis Campbell, Iowa State University

Portland/Benton

9:45 a.m. – 10:20 a.m.

“Highlighted Speaker” “Biophysical, Biochemical, And Bioanalytical Approaches To Characterize Diverse Molecular Details Of Ras‐Related Proteins” Paul D. Adams* Department of Chemistry and Biochemistry, University of Arkansas, Fayetteville, AR 72701

10:20 a.m. – 10:40 a.m.

“Monolayers With Self‐Limiting Packing Densities For The Inhibition Of Nonspecific Protein Adsorption” Marlon L. Walker1*and David J.Vanderah2 1Surface and Microanalysis Science Division 2Biochemical Sciences Division 18


PROGRAM SCHEDULE

10:40 a.m. – 11:00 a.m.

11:00 a.m. – 11:20 a.m.

11:20 a.m. – 11:40 a.m.

Chemical Science and Technology Laboratory, National Institute of Standards and Technology, Gaithersburg, MD 20899 “Determination Of Absolute Configurations Of 1,N‐Chiral Diols Using The Fluorinated Porphyrin Tweezer Via Exciton Coupled Circular Dichroism (ECCD)” Sumira Y. Stein, Xiaoyong Li, Babak Borhan* Michigan State University, Department of Chemistry, East Lansing MI 48824 “The Molecular Characterization Of Maize Fatty Acid Elongase” Alexis A Campbell*, and Basil J Nikolau Iowa State University, Department of Biochemistry, Biophysics and Molecular Biology Ames, IA, 50011 “Functional Analysis Of Maxi‐K Potassium Channels In Tethered Bilayer Lipid Membranes On A GOLD SUBSTRATE” George O. Okeyo*1, Daniel Fine2, Ananth Dodabalapur2, Rebecca B. Price3, Peter A. V. Anderson3 and Randolph S. Duran1 1University of Florida, Department of Chemistry, Gainesville, FL 32611, 2University of Texas at Austin, Microelectronics Research Center, Austin, TX 78712, 3University of Florida, Whitney Laboratory for Marine Bioscience, St. Augustine, FL 32080 Technical Session 4 9:45 – 11:45 a.m. Physical Chemistry (ʺTitle,ʺ Presenter, Co‐Author(s), Affiliation) Session Chair: Darlene K. Taylor, Ph.D., North Carolina Central University

Tuesday, a.m.

Parkview

9:45 a.m. – 10:05 a.m.

“High Spectral Resolution Infrared Study Of Hydrocarbons In The Jovian Atmosphere” Ramsey L. Smith*1,2, Theodor Kostiuk1, Timothy A. Livengood1,3, Kelly E. Fast1, Tilak. Hewagama1,3, Juan D. Delgado1,3, and William Blass4 1NASA Goddard Space Flight Center, Code 693, Greenbelt, MD 20771 19


PROGRAM SCHEDULE 2Oak Ridge Associated Universities/ NASA Postdoctoral Program, Oak Ridge, TN 37831 3Department of Astronomy, University of Maryland, College Park, MD 20742 4Department of Physics, University of Tennessee, Knoxville, TN 37996 10:05 a.m. – 10:25 a.m.

10:25 a.m.‐ 10:45 a.m.

“High‐Accuracy ab initio Studies Of Sn (n=1‐4) Electronic Structure” John A.W. Harkless* Department of Chemistry, Howard University, 525 College St., NW, Washington, DC 20059 “Quantum Mechanical Prediction Of 1H And 13C NMR Chemical Shifts In Large Protein Systems” Duane Williams*1, Bing Wang1 and Kenneth M. Merz, Jr.1 1University of Florida, Department of Chemistry & Quantum Theory Project, Gainesville, FL 32608

10:45 a.m. – 11:05 a.m.

“Gold Nanoparticle Based NSET Assay For Monitoring RNA Folding Kinetics” Jelani K. Griffin*, Uma S. Rai and Paresh C. Ray Department of Chemistry, Jackson State University, Jackson, MS, 39217

11:05 a.m. – 11:25 a.m.

“Reactive Coatings: Neutralizing‐Decontaminating Coating For Chemical Warfare Agents” Dave A Jenkins* and H. Neil Gray The University of Texas at Tyler, Department of Chemistry, Tyler, TX, 75799 “The Temporal Changes In The Emission Spectrum Of Comet 9P/ Tempel 1 After Deep Impact” William M. Jackson1, XueLiang Yang1, Xiaoyu Shi1 and Anita L. Cochran2 Department of Chemistry, University of California, Davis1 and McDonald Obervatory, University of Texas at Austin2

11:25 a.m. – 11:45 a.m.

Tuesday, a.m.

Technical Session 5 9:45 – 11:45 a.m. Dr. Henry McBay Outstanding Teacher Award Symposium – STEM Education (ʺTitle,ʺ Presenter, Co‐Author(s), Affiliation) Michael Page, Ph.D., California State Polytechnic University Pomona 20

Aubert


PROGRAM SCHEDULE 9:45 a.m. – 10:05 a.m.

Dr. Henry McBay Outstanding Teacher Awardee “Enhancing The Design Of Classical Physical Chemistry Laboratory Experiment In Order To Appeal To Students: Determining The Heat Of Vaporization (∆Hvap) Of A Pure Liquid” Shawn M. Abernathy*, Ph.D.* and Anwar D. Jackson Howard University, Department of Chemistry, Washington, DC 20059

10:05 a.m. – 10:25 a.m.

“Affecting Science Motivation Of High School Students Through Enrichment Programs And Peer Instruction” George D. Howell, Edward Walton, Laurie Riggs, and Michael F. Z. Page* Email: mfpage@csupomona.edu Chemistry Department, California State Polytechnic University Pomona 3801 W. Temple Ave. Pomona, CA 91768 “Establishing Effective Summer Camp Programs In Nanoscale Science For High School Students” Sherine O. Obare* Department of Chemistry and the Nanoscale Science Program University of North Carolina at Charlotte, Charlotte, NC 28223 “Transitioning To College: Using Research To Bridge The Culture Gap” Dr. Alvin P. Kennedy Morgan State University, Department of Chemistry, Baltimore, MD 21133 “Innovations In Science Outreach: The Importance Of Legitimate Scientific Discovery” Kenya T. Powell*1,2, Carolyn J. Anderson2, and Vicki L. May1

10:25 a.m. – 10:45 a.m.

10:45 a.m. – 11:05 a.m.

11:05 a.m. – 11:25 a.m.

1Science Outreach Office and the 2Departments of Chemistry and

11:25 a.m. – 11:45 a.m.

Radiology Washington University in Saint Louis, Saint Louis, MO 63130 “Show Me The Money: Funding Opportunities For Chemical Scientists (Students, Post‐Docs, Academicians, And Other Chemical Professionals) At The National Science Foundation” Chavon Renee Wilkerson* National Science Foundation, Division of Chemistry, 4201 Wilson Boulevard, Arlington VA, 22311

21


PROGRAM SCHEDULE Percy Julian Symposium & Luncheon Landmark 1‐4 (ticketed) 12:00 p.m. ‐ 1:30 p.m. Speaker: Dr. Soni Oyekan, Reforming & Isomerization Technologist, Marathon Oil Sponsored by Corning, Inc.

Tuesday p.m.

The Johns Hopkins University Applied Physics Laboratory Technical Sessions

Tuesday, p.m.

Technical Session 6 1:45 – 3:30 p.m. Biotechnology and Biochemistry Applications II (ʺTitle,ʺ Presenter, Co‐Author(s), Affiliation) Mo Hunsen, Ph.D., Kenyon College

Portland/Bento n

1:45 p.m. – 2:10 p.m.

2:10 p.m. – 2:30 p.m.

2:30 p.m. – 2:50 p.m.

“Green Chemistry Via Catalytic Reactions” Mo Hunsen* Department of Chemistry, Kenyon College, Gambier, OH 43022 “Hyaluronic Acid Derivatives For Cellular Encapsulation” TaNeshia Washington, Chris Highley, Sasha Bakhru, and Stefan Zappe* Benedict College, Columbia, SC “Peptide Targeting Of Platinum Anti‐Cancer Drug” Margaret W. Ndinguri, Sita S. Aggarwal, Robert P. Gambrell and Robert P.Hammer*. Department of Chemistry, Louisiana State University, Baton Rouge, LA 70803

2:50 p.m. – 3:10 p.m.

“Assessing The Effectiveness Of Rhein As An Anti‐Angiogenic Agent In The Treatment Of Breast Cancer” Vivian E. Fernand1, Emily E. Villar1, Robert E. Traux2, Sayo O. Fakayode3, Mark Lowry1, Jack N. Losso4, and Isiah M. Warner*1 1Department of Chemistry, Louisiana State University, Baton Rouge, LA 70803 2Biotechnology Laboratories, Louisiana State University, Baton Rouge, LA 22


PROGRAM SCHEDULE 70803 3Department of Chemistry, Winston‐Salem State University, Winston‐ Salem, NC 27110 4Department of Food Science, Louisiana State University, Baton Rouge, LA 70803

3:10 p.m. – 3:30 p.m.

“Insights Into The Cellulose Hydrolysis Mechanism Of Cytophaga Hutchinsonii Based On Computer Modeling And Site‐Directed Mutagenesis Of CEL9A” Clifford Louime*1, Michael Abazinge2 (1)College of Engineering Sciences, Technology and Agriculture, Florida A&M University, 6505 Mahan Drive, Tallahassee, FL 32307 (2) Environmental Sciences Institute, FSH Science Research Center, Florida A&M University, 1520 South Bronough Street, Tallahassee, FL 32307

Technical Session 7 1:45 – 3:30 p.m. Graduate Student Sci‐Mix Symposium (ʺTitle,ʺ Presenter, Co‐Author(s), Affiliation) Session Chair: Sharon Kennedy, Ph.D., Colgate‐ Palmolive Company

Tuesday, p..m.

Aubert

1:45 p.m. – 2:05 p.m.

2:05 p.m. – 2:25 p.m.

Eastman Kodak Dr. Theophilus Sorrell Fellowship Awardee “Nanoparticle‐Based Selective Colorimetric Sensor For Organophosphorus Pesticides” Tova A. Samuels and Sherine O. Obare* Department of Chemistry, Western Michigan University, Kalamazoo, MI 49008 Dow Chemical Company Fellowship Awardee “Using Functionalized Nanoparticles To Study Intracellular Response Central To The Progression Of Osteonecrosis” Fedena Fanord1, Korie Fairbairn1, Harry Kim2, Venkat Bhethanabotla1, Vinay K. Gupta*1 1University of South Florida, Department of Chemical & Biomedical Engineering, Tampa, FL 33620 2Shriners Hospitals for Children, Tampa, FL 33612 23


PROGRAM SCHEDULE 2:25 p.m. – 2:45 p.m.

2:45 p.m. – 3:05 p.m.

3:05 p.m. – 3:25 p.m.

Procter and Gamble Fellowship Awardee “Next Generation Carbon Monoxide Gas Sensing” Adedunni D Adeyemo*1, Prabir K Dutta1 The Ohio State University, Department of Chemistry, Columbus, OH 43220 Lendon N. Pridgen, GlaxoSmithKline ‐ NOBCChE Fellowship Awardee “Overriding Diastereoselective Felkin Additions To Give Anti Felkin Products” Gretchen R. Stanton, Patrick J. Walsh* University of Pennsylvania, Department of Chemistry, Philadelphia, PA 19104 E.I. Dupont Fellowship Awardee “Inducer Effects On Lac Repressor‐Mediated DNA Loops: Single molecule FRET Studies” Kathy Goodson1*, Aaron R. Haeusler1, Doug English2, Jason D. Kahn1, 1University of Maryland College Park, College Park, MD, 20742, 2Wichita State University, Wichita, KS, 67260

Tuesday, p.m.

3:30 p.m. ‐ 4:30 p.m. Tuesday, p.m.

The Chemistry of Forensic Science 1:45 p.m. ‐ 3:30 p.m Hosted by DEA/South Central Laboratory

Pershing

Exhibitors Meeting

Plenary III ‐ Health Symposium 4:00 p.m. ‐ 6:00 p.m. Landmark 6‐7 “Diabetes Updates” sponsored by Eli Lilly Company Dr. Ronald D. Lewis, II, Chair, 2009 NOBCChE Health Symposium Local representatives of the ADA (American Diabetes Association)

Moderator: Presenters: Questions and Answers Open to the Floor Closing Remarks

Dr. Ronald D. Lewis, II 24


PROGRAM SCHEDULE 6:00 p.m. ‐ 8:00 p.m.

Exhibitorʹs Welcome Reception

Landmark 4

Wednesday, April 15 7:00 a.m. ‐ 7:30 a.m.

Student Planning Meeting

Convention Center, Room 200

7:15 a.m. ‐ 7:45 a.m.

NPC Committee Meeting

Lafayette

Wednesday a.m.

Teachers Workshop II 7:00 a.m. ‐ 5:00 p.m. “Achieving Science Through Education”

Landmark 5

Sponsored by 3M, AAAS, and Committee for Action Program Services

Moderator 9:00 a.m. ‐ 11:45 a.m.

10:00 a.m. – 10:15 a.m. 12:00 N – 1:00 p.m. 1:00 p.m. – 2:30 p.m.

2:45 p.m. ‐3:30 p.m.

9:00 a.m. ‐ 4:00 p.m.

Mrs. Linda Davis, Committee Action Program Services Cedar Hill, TX “The Future of Math Education” Mr. Gerald W. McElvy, President, Exxon Mobil Foundation, Dallas, Texas Break Lunch “African Foundations of Western Math, Science & the Global Context of Five River Civilizations” Dr. James Grainger, Analytical/Environmental Chemist Centers for Disease Control and Prevention, Atlanta, GA Roundtable Discussion ‐ Teachers & Presenters

Conference Registration 25

Landmark Foyer/Reg Office


PROGRAM SCHEDULE

Wednesday a.m.

CAREER FAIR EXPO 9:00 a.m. ‐ 6:00 p.m.

Hall 1, Convention Center

Wednesday a.m.

Professional Development Workshop: 9:00 a.m. ‐ 11:00 a.m. Utilizing The STAR Guest Speaker ‐ Carolyn Greco President and CEO THE FACET GROUP

Kingsbury

Wednesday a.m.

Professional Development Workshop: 9:00 a.m. ‐‐ 10:30 a.m. NSF Graduate Research Fellowship Informational Session William Hahn, Ph.D. National Science Foundation

Pershing/Lindell

Wednesday a.m.

Professional Development Workshop: 9:00 am. ‐‐ 11:00 a.m. ʺAcademia: What Are Your Options,ʺ Isiah Warner, Ph.D., Department of Chemistry Louisiana State University

Wednesday, a.m.

Professional Development Workshop: 10:00 a.m. ‐ 11:30 a.m. Parkview ACS: Managing An Effective Job Search (pt 1) Presenter: Patrick Gordon 26

Landmark 6


PROGRAM SCHEDULE

Wednesday, a.m.

Professional Development Workshop 11:15 a.m. ‐ 12:15 6. p.m. “Lets Talk Graduate School”

Landmark 6

Presenter

G. Dale Wesson, Ph.D., PE Interim Vice President for Research Florida Agricultural and Mechanical University

12:00 p.m. ‐ 1:00 p.m

1:00 p.m. ‐3:00 p.m.

Wednesday, p.m.

1:00 p.m. ‐‐ 5:00 p.m.

Convention Center

LUNCH ON YOUR OWN

Professional Development Workshop: Utilizing The STAR Guest Speaker ‐ Carolyn Greco President and CEO THE FACET GROUP

Kingsbury

ACS: Managing An Effective Job Search (parts 1 & 2) 1:00 p.m. ‐ 4:30 p.m. Presenter: Patrick Gordon Poster setup for students 27

Parkview

Convention Center Room 228 and 229


PROGRAM SCHEDULE Professional Development Workshop: 1:30 – 3:30 p.m. Landmark 3 “What It Takes To Find A Job” Nick Nikolaides, Ph.D. Manager, Doctoral Recruiting & University Relations The Procter & Gamble Company

Wednesday, p.m.

3:00 p.m. ‐ 4:00 p.m.

Science Fair and Science Bowl Judges Meeting

Convention Center, Room 200

5:30 p.m. ‐ 9:30 p.m.

Science Competition Registration & Opening Meeting

Landmark 5&6

Wednesday, p.m.

1

2

NOBCChE Scientific Exchange Poster Session 4:00 – 6:00 p.m.

Convention Center Hall 1

“Studies of Bis(monoacylglycero)phosphate (BMP) Model Lipid Membranes Using Analytical Methods” Janetricks N. Chebukati* and Gail E. Fanucci University of Florida, Department of Chemistry, Gainesville, Fl, 32611 “Synthesis and Characterization of Dual Property Magnetic Ionic Liquid Nanoparticles for Application in the Treatment of Various Forms of Cancer” Stacie LeSure Gregory Department of Chemistry, Louisiana State University, Baton Rouge, LA 70803

3

“Use Of EDTA To Minimize Ionic Strength Frequency Shifting Effects In The 1H NMR Spectra Of Urine” Vincent Asiago, G. A. Nagana Gowda, Shucha Zhang, Narasimhamurthy Shanaiah, Jason Clark, and Daniel Raftery* Department of Chemistry, Purdue University,, West Lafayette, IN‐ 47905

28


PROGRAM SCHEDULE 4

5

6

7

8

9

10

“Synthesis And Complexation Properties Of Aza‐Crown Ether Containing Chromo‐ And Fluoroionophores” Shihab D. Deiab_, Edikan Archibong, Marsha Boatwright, Michael M. Lebel, Jason Caldwell, Nelly N. Mateeva* Department of Chemistry, Florida A&M University, Tallahassee, FL 32307 “Epoxy Nanocomposites: Process Of Polymerization And The Effect Of Nanoclay Percent Loading On Thermal Properties” Abisola B. Ajayi*, Dr. Alvin P. Kennedy Morgan State University, Department of Chemistry, Baltimore MD 21251 “Dual Atomic Absorption And Atomic Fluorescence Measurments Of Mercury In Environmental And Biological Samples After A Single Combustion Event” Candice Tolbert and Dr. James Cizdziel* Department of Chemistry and BioChemistry, University of Mississippi, University, Ms 38677 “Application Of Ratiometric Spectral Properties Of Salicylidene Derivatives In The Analysis Of Selected Anions” Dharendra Thapa, Richard Williams*, and Yousuf Hijji Morgan State University, Department of Chemistry, Baltimore, MD 21234 “An Investigation Of The Use Of Chitosan As A Substitute For 3‐(Amino‐Propyl) Triethoxysilane (Aps) In The Fabrication Of Glass Surfaces For Use As Substrates In Metal Enhanced Fluorescence Techniques” Ichhuk Karki*, Richard Williams Morgan State University, Chemistry Department, Baltimore, Maryland, 21251 “Investigation Of Ruthenium Complexes And Heptamethine Cyanine Near‐ Infrared Fluorophores As Donor/Acceptor Groups For Fluorescence Resonance Energy Transfer (FRET) Analysis” Isha Pradhan*, Richard Williams Morgan State University, Chemistry Department, Baltimore, Maryland, 21251 “Antioxidant Potential Of Teas: Effect Of Adding Milk” Jennifer Brown_ and Nixon Mwebi* Jacksonville State University, Department of Physical & Earth Sciences, Jacksonville AL 36265 29


PROGRAM SCHEDULE 11

“Host‐Guest Chemistry Of Cyclodextrins And Labeled Drugs”

12

Marsha Boatwright_, Edikan Archibong, Shihab D. Deiab, Jonny Williams, Kelly N. Mateeva* Department of Chemistry, Florida A&M University, Tallahassee, FL 32307 “Chitosan‐Assisted Synthesis Of Silver Nanoparticles By Electrodeposition”

13

Melissa A Pinard, Yongchao Zhang* Morgan State University, Chemistry Department, Baltimore, MD, 21251 “High Density Fluidic Network With Integrated Embedded Waveguide For High Throughput Screening: Application In Drug Discovery” Paul I. Okagbare*1, Jost Gottert4, Proyag Datta4 and Steven A. Soper1,2,3 Department of Chemistry1, Department of Mechanical Engineering2, Center for BioModular Multi‐Scale Systems3, and Center for Advanced Microstructures and Devices,4 Louisiana State University, Baton Rouge, Louisiana

14

“Electrodeposited Chitosan/Silver Nano Particle Composites Improve The Sensitivity Of An Enzyme Based Phenol Sensor” Yanique Thomas, Yongchao Zhang* Morgan State University, Chemistry Department, Baltimore, MD, 21251

15

“Plasmon Resonance Behavior Of N‐Homocysteinylated Gold Nanobioconjugates” Christina M. Jones1, Isiah M. Warner*1, Arther T. Gates1, James W. Robinson1, Robert M. Strongin2 1Department of Chemistry and College of Basic Sciences, Louisiana State University, Baton Rouge, Louisiana 70803 2Department of Chemistry, Portland State University, Portland, Oregon 97207

16

“Aza‐Crown Ether Containing Spectrophotometric Reagents For Complexation With Hg(II) Ions” Edikan Archibong_, Shihab D. Deiab, Marsha Boatwright, Michael M. Lebel, Mercedes Jackson, Nelly N. Mateeva* Department of Chemistry, Florida A&M University, Tallahassee, FL 32307

30


PROGRAM SCHEDULE 17

“Synthesis Of Porphyrin‐Peptide Conjugates With Affinity For Epidermal Growth Factor Receptor” Alecia M. McCall, M. Graca H. Vicente* Louisiana State University, Department of Chemistry, Baton Rouge, LA, 70803

18

19

“Dynamics Of Repression By Native And Pre‐Assembled Cro Dimers In Living Bacteria” Jacqueline J. Harris, Michael C. Mossing* Department of Chemistry and Biochemistry, The University of Mississippi, Oxford, MS 38677 “A Study Of The Self‐Assembly Of Water‐Soluble Porphyrins In Aqueous Solution”

20

Javoris V. Hollingsworth, Paul Russo and M. Graca. H. Vicente* Louisiana State University, Department of Chemistry, Baton Rouge, LA 70803 “Testing A Model: Ca2+ Induced Exposure Of Tryptophan”

21

Chinelo Udemgba, Nagamani Vunnam, Yogini Bhavsar and Dr. Susan Pedigo* Department of Chemistry and Biochemistry, University of Mississippi, University, MS 38677‐1848 “Spontaneous Rhythmic Contraction Of The Urinary Bladder” Joseph Mburu3, Vikram Sabarwal1, Corey Johnson2, Adam Klausner2, Paul Ratz1* 1Departments of Biochemistry and Pediatrics, and 2Department of Surgery/Division of Urology, Virginia Commonwealth University, Richmond, VA, and 3Department of Biochemistry, North Carolina State University, Raleigh, NC

22

“Constructing A Reporter Vector For Evaluating Synthetic RNA Elements Regulating Eukaryotic Translation In Vitro” 1Kofi Atta‐Boateng_, 2Stephen J. Goldfless, 2Jacquin C. Niles* 1Albany State University, Albany, GA 31705, 2Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139

31


PROGRAM SCHEDULE 23

“Nutritional Mechanisms That Promote A Healthy Circulatory System”

24

Harbour MA, Caldwell JE Michigan State University, East Lansing, MI “Characterization Of Active Transporter Systems At Blood‐Brain Barrier”

25

Shanika N. Smith*, Johnmesha L. Sanders, Antonie H. Rice, PhD. University of Arkansas at Pine Bluff, Chemistry, Pine Bluff, AR 71601. “Anisomycin – Indueed Jnk Activation Via The Ribosomal Interaction” Dara Phillips, Hee Kyong Bae, and James Pestka* Michigan State University, Department of Food Science and Human Nutrition, East Lansing, MI 48825

26

“Preparation Of 5‐Aryl Pyrazole ‐3‐ Carboxylates For Ligand And Sphingosine Kinase Inhibitor Syntheses”

27

Demetrius Miles and Christian Grattan* Winthrop University “Hollow Fiber Filtration Of Hemoglobin”

28

Frederick Smalls and Andre Crawford* Ohio State University, Columbus, OH “Reusable Solid Rocket Motor Ballistics: Low Level Tail‐Off Analysis”

29

30

Leethaniel Brumfield, III* and Stanley Tieman NASA, George C Marshall Space Flight Center, Redstone Arsenal Propulsion Systems Dept, Huntsville, AL 35812 “Protection Against Chemically –Potentiated Liver Injury Is Detected By Cyanine Fluorescence” Evelyne Ntam, Tricia Charles1, Roxanne Howell, Michael Baker, Dwayne Hill*. Department of Biology, Morgan State University, Baltimore MD 21251. “Synthesis And Characterization Of Bimetallic Zintl Clusters” Domonique O. Downing* and Bryan W. Eichhorn University of Maryland, Department of Chemistry and Biochemistry, College Park, MD 20742 32


PROGRAM SCHEDULE 31

“Ruthenium Polypyridine Bisthioethers For Use As Pdt Agents”

32

Robert N. Garner and Claudia Turro* The Ohio State University, Department of Chemistry, Columbus, OH 43210 “Synthesis Of High Free Volume Acid For Proton Conducting Electrolytes”

33

LaRico Treadwell and Dr. Jason Ritchie * Department of Chemistry and BioChemistry, University of Mississippi, University, Ms 38677 “Electronic Conductive Polymers With Biospecific Binding Capacities: New Materials For Nanoscale Biosensors” 1 Reuven Darkeyah*, 1 Sannigrahi Biswajit, 1 Khan Ishrat*, 2 Sil Dwaipayan, 2 Baird Barbara* 1Department of Chemistry, Clark Atlanta University Atlanta GA 30314, 2Department of Chemistry and Chemical Biology, Cornell University

34

Ithaca, NY 14853 “Quantum Electronic Stability In Noncovalent Functionalization Of Carbon Nanotubes” Olayinka O. Ogunro† and Xiao‐Qian Wang‡*

35

36

Clark Atlanta University, Department of Chemistry†, Department of Physics‡, Center for Functional Nanoscale Materials*, Atlanta, GA 30314 “Evaluating How The Slight Modification Of A Donor GROUP Substitutient Effects Electron Transfer Efficiency In Paraphenylene Dimmers” Jeremy Lipscomb and Darlene K. Taylor* Department of Chemistry, North Carolina Central University, Durham, NC 27707 “The Effects Of Temperature On A Cross Linked Hyperbranched Polyglycerol‐ Drug Conjugate” Melony A. Ochieng and Darlene K. Taylor * Department of Chemistry, North Carolina Central University Durham, N.C. 27707

33


PROGRAM SCHEDULE 37

“Synthesis Of Thiophene Monomers Using The Grignard Reaction” Stephen MaffettI, Robin LaskowskiII, Malika Jeffries‐ELII* ILouisiana State University, Baton Rouge, LA 70803

38

IIIowa State University, Ames, IA 50011 “Mechanistic Studies Of Gold(I)‐Catalyzed Intramolecular Hydroamination And Hydroalkoxylation With Allenes”

39

Alethea N. Duncan* and Ross A. Widenhoefer Duke University, Chemistry Department, Durham, NC 27708 “Synthesis Of Novel Diruthenium Coupled Nucleobase Complexes”

40

Darryl Anthony Boyd*, Tong Ren Department of Chemistry, Purdue University, West Lafayette, IN, 47907 “Studies On The Synthesis Of Spiroisoxazolines”

41

Erick D. Ellis, and Ashton T. Hamme II* Department of Chemistry, Jackson State University, Jackson, Mississippi, “Self Assembly Of Halogenated Polycyclic Aromatic Carboxyl

42

Josette Crout Seibles* Department of Chemistry, Rutgers University, Piscataway, NJ “Synthesis Of Novel Epoxy Gemini Surfactants From Vernonia Oil”

43

Nikki S. Johnson*, Folahan O. Ayorinde Howard University, Department of Chemistry, Washington, DC, 20059 “Selective, Stoichiometric Ligand‐Enabled Oxidation Of Sp2 And Sp3 C‐H Bonds Via Palladacycles With Hydrogen Peroxide”

44

Williamson Oloo, N. Zhang, Vedernikov Jing, and N. Andrei Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland “Synthesis Of Spiro‐Isoxazolines Via Intramolecular Cyclization” Brittny C. Davis, Ann O. Omollo, Eric McClendon, Lungile Sitole, and Ashton T. Hamme II* Department of Chemistry, Jackson State University, Jackson, MS, 39217 34


PROGRAM SCHEDULE 45

“Progress Towards The Development of Potential Pathogen Biosensor”

46

Charlee K. McLean*, Dr. Angela Winstead* Department of Chemistry, Morgan State University, Baltimore, MD 21251 “Microwave Assisted Conversion Of Aldoximes To Nitriles”

47

Chidi Anyanwutaku, Dr. Yousef Hijji* Morgan State University, Department of Chemistry, Baltimore, MD 21251 “Approaches Toward The Atroposelective Synthesis Of Chiral Polyaryls”

48

Donovan Thompson, Alan McDonald, and Dr. Karelle Aiken* Chemistry, Georgia Southern University, Statesboro, GA 30460 “A Simple Highly Efficient Method For The Synthesis Of Nitriles”

49

50

Emmanuel Dowuona, Dr. Yousef Hijji* Morgan State University, Department of Chemistry, Baltimore, MD 21251 “Understanding Why The Strongest Halide Binding Occurs With The Weakest Hydrogen Bond Donors In Triazolophanes” Esther O. Uduehi, Yuran Hua, Kevin P. McDonald, Jonathan A. Karty and Amar H. Flood* Chemistry Department, Indiana University, Bloomington, IN, 47405 “Microwave Assisted Synthesis Of Non‐Symmetric Near‐Infrared Dyes” Jamiece E. Johnson*, Dr. Angela Winstead* Department of Chemistry, Morgan State University, Baltimore, MD, 21251

51

52

“Synthesis And Photophysical Characterisation Of Hepthamethine Cyanine Dyes” Stanley N. Oyaghire*, Dr. Angela Winstead*, Dr. Richard Williams* Department of Chemistry, Morgan State University, Baltimore, MD 21251 “Characterization Of Model Systems For The Development Of A Single Molecule Trap” Dominique A. Brooks, Christine A. Carlson, Jorg C. Woehl* Department of Chemistry and Biochemistry , University of Wisconsin‐Milwaukee Milwaukee, WI 53201 35


PROGRAM SCHEDULE 53

54

55

56

57

58

59

“Substituent Effects On The Energetics Of Trans To Cis Isomerization In Cyclohexene” Jeffrey D. Veals* and Dr. Steven R. Davis Department of Chemistry and BioChemistry, University of Mississippi, University, MS 38677 “Probing Phenylalanine/Adenine Π‐Stacking Interactions In Protein Complexes With Explicitly Correlated And CCSD(T) Computations” Kari L. Copeland and Gregory S. Tschumper* University of Mississippi, Department of Chemistry and Biochemistry, University, MS 38677 “A Photoacoustic Calorimetry Investigation Of The Excited‐State Properties Of The Oxygen‐Transport Protein Hemerythrin” Shawna N. Lee*, Maurice Edington Florida A&M University, Department of Chemistry, Tallahassee, FL 32304 “A Spectroscopic Investigation Of The Ultrafast Decay Dynamics Of The Dioxygen Carrier Protein Hemocyanin” Tarah A. Word and Maurice Edington* Department of Chemistry, Florida A & M University, Tallahassee FL, 32307 “Identification Of Compact Basis Sets For The Reliable Characterization Of Higher‐Order Correlation Effects In Π‐Type Interactions” Brittney D. Smith and Dr. Gregory S. Tschumper* The University of Mississippi, Department of Chemistry and Biochemistry University, MS 38677 “Tunable Ag‐‐Nanoparticle Surface Plasmon Absorption And Its Effect On Surface Enhanced Raman Scattering (SERS) Activity” Christen M. Robinson, Dulal Senapati and *Paresh C. Ray Jackson State University, Department of Chemistry Jackson, MS‐39216 “A Preliminary Photoacoustic Calorimetry Investigation Of The Nonradiative Relaxation Processes Of Photoactive Yellow Protein” Johnny Williams and Maurice Edington* Department of Chemistry, Florida A&M University, Tallahassee FL, 32307 36


PROGRAM SCHEDULE “Coupled Dielectric And Thermochemical Studies Of The Influence Of Curing Agent Structure On Epoxy-Amine Cure”

60

Abdul-Rahman O. Raji*, Alvin P. Kennedy, and Solomon Tadesse Morgan State University, Department of Chemistry, Baltimore, MD 21251 “Laser Induced Breakdown Spectroscopy In Biological Systems”

61

Marquis Gordon*, Tia Mitchell, Lewis Johnson, and Maurice Edington Department of Chemistry, Florida A&M University, Tallahassee FL, 32307

Thursday, April 16

7:30 a.m. ‐ 9:30 a.m.

Science Fair Judging

Convention Center Room 228 and 229

7:15 a.m. ‐ 7:45 a.m.

NPC Committee Meeting

8:00 a.m. ‐ 8:30 a.m.

Student Planning Meeting

8:00 a.m. ‐ 4:00 p.m.

Conference Registration

Lafayette Convention Center, Room 200 Landmark Foyer/Reg Office

Plenary V: Alternate Energy Solutions Thursday, a.m. 8:00 a.m. ‐‐ 9:00 a.m. Portland/Benton “New Lithium Battery Technology” Keynote Speaker: Dr. Levi Thompson, Associate Dean of Chemical Engineering , University of Michigan, Ann Arbor, MI sponsored by The Johns Hopkins Applied Physics Laboratory

37


PROGRAM SCHEDULE Academia: What Are your Options (pt 2) 9:00 a.m. ‐‐ 11:00 a.m. Presenter : Gregory Tew, Ph.D. UMass ‐ Amherst

Thursday, a.m

Kingsbury

Technical Session 8 9:30 – 12:00 N Alternative Energy Solutions (ʺTitle,ʺ Presenter, Co‐Author(s), Affiliation) Session Chair: Issac Gamwo, U.S. DOE

Thursday, a.m.

Parkview

9:30 a.m. – 9:50 a.m.

9:50 a.m. – 10:10 a.m.

“Redox Relays To Enhance Charge Separation Efficiency Of Photovoltaics” Melody Kelley, Silas Blackstock* University of Alabama Department of Chemistry, Tuscaloosa, AL 35487 “Reactivity Of Solvated And Presolvated “Dry” Electrons In The Ionic Liquid N‐Methyl N‐Butylpyrrolidinium Bis[(Trifluoromethyl)Sulfonyl]Imide” Jockquin D. Jones*(1), Charlene Lawson(1), Shawn M. Abernathy(1), James F. Wishart(2) “(1)Howard University, Department of Chemistry, Washington, DC 20059, (2)Brookhaven National Laboratory, Department of Chemistry, Upton, NY

10:10 a.m. – 10:30 a.m.

10:30 a.m. – 10:45 a.m.

11972 “Continuous‐Flow And Enhancement Of Reaction Rates Of Biodiesel Production Using A Slit‐Channel Reactor” Egwu Eric Kalu1*, Ken S. Chen2, Tom Gedris3 1FAMU‐FSU COE, Chemical & Biomed. Dept., Tallahassee, FL 32310 2Sandia National Laboratories, Albuquerque, NM 87185 3Florida State University, Chemistry & Biochemistry Dept., Tallahassee, FL 32306 Break

38


PROGRAM SCHEDULE 10:45 a.m. – 11:05 a.m.

11:05 a.m. – 11:25 a.m.

“Electroless Nickel‐Based Catalysts For Hydrogen Generation By Hydrolysis Of Borohydride” Shannon Anderson, Addisu Samuel, Egwu Eric Kalu*, Department of Chemical & Biomedical Engineering FAMU‐FSU College of Engineering Tallahassee, FL 32310 “Fuel Reactor Behavior Of A Chemical Looping Combustion System: Thermal Effects” Isaac K. Gamwo1 and Jonghwun Jung2 1U.S. Department of Energy, National Energy Technology Laboratory Pittsburgh, PA 15235‐094 2Technical Research Laboratory, POSCO, 1, Goedong‐dong, Nam‐gu, Gyeongbuk 790‐785, Pohang, South Korea

Technical Session 9 9:30 – 12:00 N Tools and Technologies in Analytical Chemistry I (ʺTitle,ʺ Presenter, Co‐Author(s), Affiliation) Session Chair: Emanuel Waddell, Ph.D., Oakwood University

Thursday, a.m.

Portland/Benton

9:30 a.m – 9:50 a.m.

9:50 a.m. – 10:10 a.m.

“The Effects Of Varying Ionic Strengths Of Supporting Electrolytes On A Spectroelectrochemical Sensor” Eme E. Amba*, Laura K. Morris, Sara E. Andria, Chris Bowman, Carl J. Seliskar and William R. Heineman. Department of Chemistry, University of Cincinnati, Cincinnati, OH 45221 “Novel Near Infra‐Red Dyes And Nanoparticles Derived From Ionic Liquids” David K. Bwambok1, Bilal El‐Zahab1, Mark Lowry1, Gabor Patonay2, Gary A. Baker3, and Isiah M. Warner*, 1 1Department of Chemistry, Louisiana State University, Baton Rouge, LA, 70803 2Department of Chemistry, Georgia State University, Atlanta, GA, 30302 3Chemical Sciences Division, Oak Ridge National Laboratory, Oak Ridge, TN, 37831 39


PROGRAM SCHEDULE 10:10 a.m. – 10:30 a.m.

10:30 a.m. – 10:45 a.m. 10:45 a.m. – 11:05 a.m.

“Supercritical Fluid Chromatography Study Of Anion Influence On Retention Mechanisms Using Surface‐Confined Ionic Liquids” Nyote J. Oliver, David S. Van Meter, Thomas L. Chester, Apryll M. Stalcup* University of Cincinnati, Department of Chemistry, P.O. Box 210172, Cincinnati, OH, 45220 Break

11:05 a.m. – 11:25 a.m.

“Increased Light Extraction Of Inasgasb Led Through Wet Chemical Etching” Deandrea L. Watkins*, Jonathon T. Olesberg, Thomas F. Boggess, and Mark A. Arnold The University of Iowa Chemistry Department, Iowa City, IA, 52242 “Ters Of Quinolinium Tricyanoquinodimethanides On Silver” Melissa Fletcher,† D. M. Alexson, § Sharka Prokes,§ Orest Glembocki,§

11:25 a.m. – 11:50 a.m.

Alberto Vivoni,£ Charles Hosten†* †Department of Chemistry, Howard University, Washington DC, 20059 §Naval Research Laboratory, Washington DC, 20375 £ Department of Biology, Chemistry, and Environmental Sciences, Inter American University, San German, PR 00683‐9801 “Surface Modification Of Polymer Substrates By Excimer Radiation” Holly Carrell1, Stephen Shreeves2, Christopher Perry3, and Emanuel Waddell*2 1University of Alabama in Huntsville, Department of Chemistry, Huntsville, AL 35899 2Oakwood University, Department of Chemistry, Huntsville, AL 35896 3Loma Linda University, School of Medicine, Department of Biochemistry,

Loma Linda, CA 92350 40


PROGRAM SCHEDULE

Thursday, a.m.

10:00 a.m. – 10:20 a.m.

2009 Rohm and Haas Undergraduate Competition Co‐sponsored by Colgate‐Palmolive Company and Lubrizol Corporation 10:00 a.m. – 12:00 Non

Pershing/Lindell

2009 Rohm and Haas Undergraduate Award Winner “Novel Graphene Nanocutting Approach Through Controlled Fracture” Rhonda Jack*,§, Dipanjan Sen*, Markus J. Buehler*,† * Laboratory for Atomistic and Molecular Mechanics, Department of Civil and Environmental Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave. Room 1‐235A&B, Cambridge, MA, USA § Department of Chemical Engineering, Hampton University, Tyler

10:20 a.m. – 10:40 a.m.

10:40 a.m. – 11:00 a.m.

11:00 a.m. – 11:20 a.m.

11:20 a.m. – 11:40 a.m.

Street, Hampton VA, 2009 Rohm and Haas Undergraduate Award Winner “Coupled Dielectric And Thermochemical Studies Of The Influence Of Curing Agent Structure On Epoxy‐Amine Cure” Abdul‐Rahman O. Raji*, Alvin P. Kennedy, and Solomon Tadesse Morgan State University, Department of Chemistry, Baltimore, MD 21251 2009 Colgate‐Palmolive Undergraduate Award Winner “Asymmetric Conjugate Addition: Synthesis Of (+)‐Kalkitoxin” Everett W. Merling, Nina R. Collins and Richard J. Mullins Department of Chemistry, Xavier University, Cincinnati, OH 2009 Colgate‐Palmolive Undergraduate Award Winner “Synthesis Of Chalcone Derivatives For Use As Anti‐Proliferative Agents On Glioblastoma Cells” Debra Ragland and Marion A. Franks, Ph.D.* Department of Chemistry, North Carolina Agricultural and Technical State University, Greensboro, North Carolina 27411. 2009 Lubrizol Corporation Undergraduate Award Winner “The Effect Of Solvents On The Rheology Of Polymer Solutions” Folorunso S. Adu and Jude O. Iroh 41


PROGRAM SCHEDULE 11:40 a.m. – 12:00 a.m.

University of Cincinnati, Cincinnati, Ohio 2009 Lubrizol Corporation Undergraduate Award Winner “The Synthesis Of Coumarins For Prostate Cancer Chemoprevention” B. Mills & M. A. Franks, Ph.D. Department of Chemistry, North Carolina A & T State University Greensboro, NC 27411

Thursday, a.m.

Science Bowl Competitions: Junior Division++ 10:00 a.m. – 12:30 p.m. sponsored by Agilent Technologies and ACS Department of Diversity Programs

Convention Center, Room 222, 223, 224

Convention Center Room 228 & 229

10:00 a.m. ‐‐ 5:00 p.m.

Science Fair Viewing

10:00 a.m. ‐‐ 12:00 p.m.

NOBCChE ‐ HBCU Panel “Increasing STEM Institutional Capacity: HBCU/HSI Strategic Aubert Alliances”

12:00

Lunch on own (Venders will be in Convention Center

Convention Center

Thursday, p.m. Morerators: Presenters:

Milligan Symposium Pershing/Lindell 1:00 p.m. ‐ 3:30 p.m. Marlon L. Walker, Ph.D. ‐ NIST Janie Ruett‐Robey, Ph.D. ‐ University of Maryland To Be Announced 42


PROGRAM SCHEDULE

Thursday, p.m.

Science Bowl Competitions: Senior Division++ 1:30 p.m. ‐ 5:00 p.m. sponsored by Agilent Technologies and ACS Department of Diversity Programs

Convention Center Room 222, 223, 224

Thursday, p.m.

Technical Session 10 1:00 – 5:00 p.m. Tools and Technologies in Analytical Portland/Benton Chemistry II (ʺTitle,ʺ Presenter, Co‐Author(s), Affiliation) Session Chairs: Aleeta Powe, Ph.D., University of Louisville and Charlotte Smith‐ Baker, Texas Southern University

1:00 p.m. – 1:25 p.m.

“Mass Spectrometric Studies Of Hyaluronic Acid In The Vitreous Humor” Aleeta M. Powe* University of Louisville, Department of Chemistry, Louisville, KY 40208 “Sequencing Antimicrobial Polypeptides From The American Alligator (Alligator Mississippiensis) Blood Using Mass Spectrometry” Lancia N.F. Darville*1, Mark E. Merchant2 and Kermit K. Murray1

1:25 p.m. – 1:45 p.m.

1Louisiana State University, Baton Rouge, LA, 70803, USA and 2McNesse State University, Lake Charles, LA, 90455 1:45 p.m. – 2:05 p.m.

2:05 p.m. – 2:25 p.m.

“The Potential Of Optically Gated Vacancy Capillary Electrophoresis As An Innovative Technique To Study Enzymatic Reactions” Sherrisse A. Kelly, Rattikan Chantiwas, Douglass Gilman* Louisiana State University, Department of Chemistry, Baton Rouge, LA 70803 “Protein Separations Using Polyelectrolyte Multilayer Coatings In Open Tubular Capillary Electrochromatography And Gradient Elution Moving Boundary Electrophoresis” 43


PROGRAM SCHEDULE Candace A. Luces1, David Ross2, Mark Lowry1, Bilal El Zahab1, Laurie Locascio2, Isiah M. Warner*1 1Department of Chemistry, Louisiana State University, Baton Rouge, LA 70803 2Chemical Science and Technology Laboratory, National Institute of

2:25 p.m. – 2:45 p.m.

2:45 p.m. – 3:00 p.m. 3:00 p.m. – 3:25 p.m.

3:25 p.m. – 3:50 p.m.

3:50 p.m. – 4:10 p.m.

Standards and Technology, Gaithersburg, MD. 20899 “Toward A Theory Of Achiral Molecular Micelle‐Protein Complexation: Analysis Of The Interaction Of Proteins With Poly (N‐Undecylenic Sulfate)” Monica R. Sylvain*, Bilal El‐Zahab, Mark Lowry, Isiah M. Warner Department of Chemistry, Louisiana State University, Baton Rouge, LA 70803 Break “Fabrication With Chitosan For Biosensors” Yongchao Zhang* Morgan State University, Chemistry Department, Baltimore, MD, 21251 “The Development Of A Colorimetric Cyanide Anion Sensor In Aqueous Solutions” Yousef M. Hijji*, Belygona Barare Chemistry Department, Morgan State University, Baltimore MD 21251 “Spectroscopic Investigations Of Heterogeneous Wetting And Molecular Delivery From Nanoporous Silica Particles” Reygan M. Freeney*1, Mark A. Lowry2, and M.Lei Geng1 1University of Iowa, Department of Chemistry and the Nanoscience and Nanotechnology Institute, Iowa City, IA 52242 2Louisiana State University, Department of Chemistry, Baton Rouge,

4:10 p.m. – 4:30 p.m.

LA, 70803 “Near‐Infrared Spectroscopy And Imaging Investigation Of Single‐Walled Carbon Nanotubes In Ionic Liquids” Kristen E. Schexnayder1, Chieu Tran*2, Irena Mejac2, Simon Duri2 1Louisiana State University, Department of Biological Sciences, Baton Rouge, LA 70803 44


PROGRAM SCHEDULE 2Marquette University, Department of Chemistry, Milwaukee, WI 4:30 p.m. – 4:50 p.m.

53201 “Hair As An Indicator Of Exposure To Pesticides” Charlotte A. Smith‐Baker*1, Momoh Yakubu2, James H. Nance1, and Mahmoud A. Saleh1 1Texas Southern University, Department of Chemistry, Houston, TX 77004 2 Texas Southern University, Department of Pharmacy, Houston, TX

1:30 p.m. ‐ 2:30 p.m.

Local Chapter Presidents Meetings (required)

Aubert, Parkview, Kingsbury, Lucas, Hawthorne

Thursday, p.m.

Professional Development Workshop: 2:30 p.m. ‐ 3:30 p.m. “GEM Workshop‐ Why Graduate School?” Marcus Huggans, Ph.D., Senior Recruiter/Programming Specialist, The National GEM Consortium

Kingsbury

Technical Session 11 3:00 – 5:15 p.m. Organic Chemistry (ʺTitle,ʺ Presenter, Co‐Author(s), Affiliation) Session Chair: Alfred Williams, Ph.D., North Carolina Central University

Thursday, p.m.

Aubert

3:00 p.m. – 3:15 p.m.

“Improving The Physico‐Chemical Properties Of Anti‐Cancer Drugs Via Co‐Crystallization” Safiyyah Forbes, Christer B. Aakeröy*, and John Desper. Kansas State University, Department of Chemistry, Manhattan, KS 66502 45


PROGRAM SCHEDULE 3:15 p.m. – 3:30 p.m.

3:30 p.m. – 3:45 p.m.

3:45 p.m. – 4:00 p.m.

4:00 p.m. – 4:15 p.m.

4:15 p.m. – 4:30 p.m.

4:30 p.m. – 4:45 p.m.

“Fluoresence Of Corannulene Based Enediynes” Teresa L. Cook, Derek Jones and James Mack* University of Cincinnati, Department of Chemistry, Cincinnati, OH 45221 “A Novel Approach To The Synthesis Of Silylated 1,3‐Alternate Calixarenes” Prima R. Tatum*, Paul F. Hudrlik, and Anne M. Hudrlik Department of Chemistry, Howard University, Washington, D. C. 20059 “Investigations Into Bacterial Communication Via Chemical Synthesis Of Autoinducer‐2 (AI‐2)” Jacqueline A.I. Smith and Herman O. Sintim* Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742 “Reactivity Of A cis‐Pd(II) Ar F Complex Towards Aryl C–F Bond Formation” Nicholas D. Ball and Melanie S. Sanford* Department of Chemistry, University of Michigan, 930 North University Avenue, Ann Arbor, Michigan 48109 “A Free Radical Cyclization Approach To The Polyandranes” Valerie C. Cwynar, Mathew G. Donahue, David J. Hart*, Grace K. Mbogo, and Dexi Yang Department of Chemistry, The Ohio State University, Columbus, OH 43210 Synthesis of Some New Benzimidazole Carboxamides as Potential Anti‐ inflammatory Agents Laine Le,1 Lygheia Lewis,1 Kinfe K. Redda2and Bereket Mochona*1 1Department of Chemistry, 2College of Pharmacy and Pharmaceutical

4:45 p.m. – 5:00 p.m.

Sciences, Florida A&M University, Tallahassee, FL 32307 “Matrix Isolation Investigation Of The Mechanism Of Tetramethylethylene Ozonolysis” Bridgett E. Coleman* and Bruce S. Ault Department of Chemistry, University of Cincinnati, Cincinnati, OH 45221 46


PROGRAM SCHEDULE Technical Session 12 3:00 – 5:00 p.m. NOBCChE Professional Chemical Engineer Award Symposium (ʺTitle,ʺ Presenter, Co‐Author(s), Affiliation) Session Chair: Angela McIver, Ph.D., University of Iowa

Thursday, p.m.

Parkview

3:00 p.m. – 3:45 p.m.

NOBCChE Professional Chemical Engineer Awardee “Calculations Of Wall Shear Stress In Left Coronary Artery For Pulsatile Flow Using Three‐Dimensional Computational Fluid Dynamics” Sahid Smith, Shawn Austin and G. Dale Wesson* Department of Chemical Engineering, Florida A&M University, Tallahassee, FL

3:45 p.m. – 4:10 p.m.

“Dendrimer‐Stabilized Fe2O3 Nanoparticles For The Growth Of Single‐

4:10 p.m. ‐ 4:30 p.m.

Walled Carbon Nanotubes By Microwave Plasma CVD” Placidus B. Amama*, Timothy D. Sands, Timothy S. Fisher Birck Nanotechnology Center, Purdue University, West Lafayette, IN 47907 “Shear Flow In Entangled Polymers Investigated Using Confocal Microscopy And Particle Image Velocimetry” Keesha A. Hayes*1, Mark R. Buckley2, Itai Cohen2 and Lynden A. Archer1 1

School of Chemical & Biomolecular Engineering, Cornell University, Ithaca,

NY 14853 2

4:30 p.m. – 5:00 p.m.

Department of Physics, Cornell University, Ithaca, NY 14853

“Biocatalytic Systems For Aromatic Oxidations: The Production Of Naphthalene Dihydrodiol” Angela M. McIver*, Tonya L. Peeples 1University of Iowa, Department of Chemical and Biochemical Engineering, Iowa City, IA 52242

5:00 p.m. ‐‐ 6:00 p.m.

Science Fair Poster Removal

47

Convention Center, Room 228 & 229


PROGRAM SCHEDULE 6:00 p.m. ‐‐ 8:00 p.m. 8:00 p.m. ‐‐ 10:00 p.m.

Thursday p.m.

National Science Competition Dinner National Science Competition Social

Convention Ctr, Room 220 and 229 Convention Ctr, Room 220 and 229

Plenary VII Landmark 7:30 pm. ‐ 10:30 p.m. Ballroom Awards Ceremony & Gala Dinner (ticketed)

Friday, April 17

8:00 a.m. ‐ 11:45 a.m.

Science Bowl Finals – Junior/Senior Division

Portland/Benton

Friday p.m.

4:00 p.m. ‐ 7:00 p.m.

Science Competition Awards Luncheon ticketed 12:00 p.m. ‐ 2:00 p.m.

Science Competition Educational Trip

48

Crystal Ballroom

St. Louis Science Center


NOBCChE 2009 EXHIBITORS

2009 Exhibitors 3M St. Paul, MN

American Chemical Society Washington, DC

Auburn University Auburn, AL

Boehringer Ingelheim Ridgefield, CT

BP Houston, TX

Centers for Disease Control and Prevention Atlanta, GA

Colgate‐Palmolive Piscataway, NJ

Corning Inc. Corning, NY

Drug Enforcement Administration Arlington, VA

The Dow Chemical Company Midland, MI 49


NOBCChE 2009 EXHIBITORS

DuPont Pawtucket, RI

Eli Lilly and Company Indianapolis, IN

Florida Agricultural & Mechanical University Tallahassee, FL

Georgia Institute of Technology Atlanta, GA

Howard University Washington, DC

Indiana University Bloomington, IN

The Johns Hopkins University Applied Physics Laboratory Laurel, MD

The Ohio State University Columbus, OH

Massachusetts Institute of Technology Cambridge, MA

Merk & Company, Inc. West Point, PA

Monsanto St. Louis, MO 50


NOBCChE 2009 EXHIBITORS

National Institute of Standards and Technologies Gaithersburg, MD

National Organization of Black Chemists and Chemical Engineers Washington, DC

NOAA Environmental Cooperative Science Center Tallahassee, FL

Oak Ridge Institute for Science and Education Oak Ridge, TN

Procter & Gamble Company Cincinnati, OH

Roche Nutley, NJ

University of California – Davis Davis, CA

University Illinois, Urbana – Champaign Champaign, IL

University of Maryland College Park, MD

University of Wisconsin – Madison Madison, WI

51


NOBCChE 2009 EXHIBITORS

University of Massachusetts Amherst Amherst, MA

Washington University in St. Louis St. Louis, MO

Western Michigan University Kalamazoo, MI

United States Environmental Protection Agency Washington, DC

United States Customs and Border Patrol Washington, DC

52


FORUM AND WORKSHOP ABSTRACTS Monday, a.m.

Henry A. Hill Lecture 10:45 ‐ 11:50

Landmark 6‐7 Sponsored by the American Chemistry Society Northeast Section Dr. Henry A. Hill 1977 ACS President

Dr. Henry Aaron Hill (1915 – 1979), the renowned African ‐ American chemist in whose memory this award was established, was a former Chairman of the ACS Northeastern Section (1963) and President of the American Chemical Society in 1977. Dr. Hill’s outstanding contributions to chemistry, particularly industrial chemistry, and to the professional welfare of chemists are legion. Dr. Hill’s first concern and interest was in his fellow humans, and this was the driving force behind all that he did both in the chemical community and the world at large. Henry Hill was a native of St. Joseph, Missouri. He was a graduate of Johnson C. Smith University in North Carolina and received the doctorate degree from M.I.T. in 1942, after getting the highest grades in his class. He began a professional career in industrial chemistry in that year, with North Atlantic Research Corporation of Newtonville, Massachusetts. He eventually rose to be vice president while doing research on and development of water‐based paints, fire‐fighting foam, and several types of synthetic rubber. After leaving North Atlantic Research, he worked as a group leader in the research laboratories of Dewey and Almy Chemical Company before starting his own entrepreneurial venture—National Polychemicals in 1952. Ten years later he founded Riverside Research Laboratories in Cambridge, Mass. The firm offered research, development and consulting services in resins, rubbers, textiles and in polymer production. Riverside Research Laboratory introduced four successful commercial enterprises, including its own manufacturing affiliate. Dr. Hill, particularly after having been appointed by President Lyndon Johnson to the National Commission on Product Safety, became active in research and testing programs in the field of product flammability and product safety. The American Chemical Society was always very close to Henry Hill’s heart. His active career with the ACS began in the middle 1950s in the Northeastern Section. Dr. Hill served on Northeastern Section committees, became a councilor in 1961 and was Chairman of the Section in 1963. He served the ACS in important National positions including secretary and chairman of the Professional Relations Committee, the ACS Council; Policy Committee, the Board of Directors, and ultimately president in 1977. He made an especially significant impact in professionalism by pioneering establishment of a set of guidelines defining acceptable behavior for employers in their professional relations with chemists and chemical engineers. This effort resulted in the ACS landmark document entitled ʺProfessional Employment Guidelines.ʺ Dr. Henry Hill remains to date as the only African American to become President of the American Chemical Society. In recognition of his many outstanding achievements, NOBCChE identifies an outstanding African – American chemist or chemical engineer to be designated as that year’s Henry A. Hill Lecturer., Dr. Richard Davis, Head, Bureau International des Poids et Mesures Mass Section, Lyon, France is this year’s honoree. Our award is sponsored by the ACS Northeast Section and the MIT Chemistry Department. 53


FORUM AND WORKSHOP ABSTRACTS Monday, a.m.

Henry Hill Lecture 10:45 – 11:45 a.m.

Landmark 6 & 7

Is the kilogram losing mass? Richard S. Davis International Bureau of Weights and Measures (BIPM) 92312 Sevres cedex, France The kilogram is the unit of mass in the International System of units (SI), sometimes referred to as the modern metric system. Although the SI has always evolved with advances in science and technology, the fact is that the definition of the kilogram (kg) has not changed since 1889. The kg is defined by the mass of a particular object, the international prototype (IPK), which is conserved at the BIPM. Is the IPK losing mass, as you may have read in the popular media? The question is incomplete. A more useful question would have specified X in this statement: “Is kg losing mass compared to X.” A good candidate for X turns out to be the mass of an atom of silicon‐28. If we could compare the IPK to the mass of a single atom of silicon‐28, and if we could carry out this experiment to a relative uncertainty of about 10‐8, we would soon have the answer to a meaningful question. Even better, we would be able to redefine the kg so that it is no longer based on the mass of a particular piece of metal, but rather on a fundamental physical constant. There are two techniques that link the IPK to a fundamental constant with an uncertainty that is within striking distance of what is required. One of these might be called the atomic kilogram, because of its direct link to a single atom of silicon‐28. The second might be called the electronic kilogram, because the direct link is to quantum electrical standards and, ultimately, to the Planck constant. I will report on progress in both experiments, on the prospects for redefinitions of the kg and related SI units as early as 2011, and on the impact of redefined SI units on science and technology.

Monday, p.m.

Opening Luncheon 12:00 ‐ 1:50 p.m. Dr. Mark S. Wrighton, Chancellor Washington University – St. Louis 54

Landmark 1‐4


FORUM AND WORKSHOP ABSTRACTS COACh Workshop

1:45 p.m. ‐ 5:30 p.m. Lindell “The Chemistry of Leadership” Presented by Sandra Shullman

Monday, p.m.

This workshop is open to women academic faculty/administrators and industry/other. This program is designed to give participants some basic concepts and tools to develop their leadership skills. Participants will learn about various concepts of leadership (including their own), explore what is known about issues that pertain to minority women and its role in leadership situations, and reflect on their own leadership challenges whether it is in the classroom/office, working with committees or leading groups. Monday, a.m.

Plenary I: Research in Oral Health 3:00 – 4:00 p.m.

Landmark 5

“Have You Considered Research In Oral Health?” Nathan Fletcher, D.D.S. Immediate Past President National Dental Association Abstract As the nation considers health care reform and improvements in efficiency in delivery and system development, a key factor will be research in areas to maximize the health of the nation. The efforts to address healthcare disparities will involve research to explore the relationship of oral health to overall health and how factors such as socioeconomics and ethnicity impact those disparities. Discussions about trial studies revolving around ethnicity are escalating with greater visibility in pharmaceuticals and health care policy decisions. The biochemistry of diabetes, periodontal disease, obesity, the inflammatory process, and genetics are of keen interest along with emerging research into genomes, biomarkers, and how chemistry is involved in aspects of oral health. We need to understand the science and engage in translational research to bridge the gap between scientific discovery and clinical delivery to begin to answer questions to improve oral health outcomes. This can be best accomplished by bringing together the scientists and clinical researchers. Underrepresented minority inclusion is essential from the aspects of trust and cultural competency to bridge that gap in the interest of the populations most in need. Reducing disparities in health care is in the best interest of the entire population

.

55


FORUM AND WORKSHOP ABSTRACTS Teachers Workshop Landmark 5 7:00 a.m. – 5:00 p.m. “Teachersʹ Embracing Science through Education”

Tuesday, a.m./p.m. Wednesday, a.m./p.m.

Sponsored by 3M, AAAS, Abbott Laboratories, ACS, NASA/UCLA, and NOBCChE This year’s science teachers’ workshop will assist science educators at the elementary, secondary, and high school levels using various teaching strategies and techniques. The 2009 workshop will also provide resources and materials that will assist in enhancing your curriculum. In addition, educators will have an opportunity to discuss issues and various challenges that face science educators. The objective for this 2 day workshop is to assist educators in improving test scores among minority and underrepresented students. This will further assist students to pursue careers in science and technology.

Tuesday, a.m.

Plenary II ‐ Biotechnology and Biochemistry 8:30 a.m. ‐ 9:30 a.m.

Portland/Ben ton

“Taking A Hit For The Team: Self‐Sacrifice As An Enzymatic Strategy In The Biosynthesis Of Lipoic Acid”

Presenter:

Squire Booker, Ph.D. Department of Chemistry, Pennsylvania State University, State College, PA

Lipoic acid is an eight‐carbon straight‐chain fatty acid containing sulfur atoms at carbons 6 and 8. In addition to its antioxidant properties, its most notable function is as a key cofactor that is employed by several multienzyme complexes that are involved in energy metabolism (pyruvate dehydrogenase and ‐ketoglutarate dehydrogenase complexes), or the catabolism of glycine (glycine cleavage system), branch‐chain amino acids (branch‐chain amino acid dehydrogenase complex), and acetoin (acetoin dehydogenase complex). In its role as a cofactor, it must be attached covalently in an amide linkage to the epsilon nitrogen of a specific lysine residue on a lipoyl carrying protein of the complex. This important post‐translational modification can be achieved via two different mechanisms: one in which exogenous intact lipoic acid is activated and then appended to a lipoyl carrying protein, and one in which lipoic acid is constructed de novo in its cofactor form onto a lipoyl carrying protein. 56


FORUM AND WORKSHOP ABSTRACTS This lecture will describe the characterization of lipoyl synthase, which catalyzes the terminal step in the de novo pathway for the biosynthesis of the lipoyl cofactor, which is the insertion of sulfur atoms at carbons 6 and 8 of an n‐octanoyl chain that is covalently bound to lipoyl carrying proteins. Lipoyl synthase is a member of the radical‐SAM superfamily of enzymes, wherein S‐adenosylmethionine is used to generate a 5’‐deoxyadenosyl 5’‐radical, which is a required intermediate in catalysis. A working hypothesis for the role of the 5’‐deoxyadenosyl 5’‐radical will be presented, as will experiments that have been conducted to test that working hypothesis. Interestingly, data will be presented that indicate that the protein is both a catalyst and a substrate.

PercyL Julian Luncheon Lecture 12:00 ‐ 1:30 p.m.

Tuesday, p.m.

Landmark 1‐4

Dr. Percy L. Julian (1899 – 1975) National Academy of Sciences (Elected 1973)

The Percy L. Julian Award for significant contributions in pure and/or applied research in science or engineering is our most prestigious award. Dr. Julian was an African‐American who obtained his BS in Chemistry from DePauw University in 1920. Although he entered DePauw as a “substandard freshman,” he graduated as the class valedictorian with Phi Beta Kappa honors. His first job was as an instructor at Fisk University. Julian left Fisk and obtained a masterʹs degree in chemistry from Harvard in 1928, and his Ph.D. in 1931 from the University of Vienna, Austria. It was after his return to DePauw in 1933 that Julian conducted the research that led to the synthesis of physostigmine, a drug used in the treatment of glaucoma2. Julian left DePauw in 1936 to become director of research of the Soya Products Division of the Glidden Company in Chicago. This position at Glidden made Julian the world’s first African – American to lead a research group in a major corporation. Dr. Julian rewarded Gliden’s faith in him by producing many new commercial products from soy beans. An entrepreneur as well as a scientist, in 1953 he founded Julian Laboratories and later Julian Associates, Inc. and the Julian Research Institute. Over the course of his career he acquired over 115 patents, including one for a fire‐extinguishing foam that was used on oil and gasoline fires during World War II2. Though he had over 100 patents and 200 scientific publications, his most notable contribution was in the synthesis of steroids from soy and sweet potato products. Dr. Julian’s life and contributions were the subject of a recent biopic by NOVA/PBS entitled, “Forgotten Genius.”3 The film was broadcast nationally on February 6, 2007 on PBS TV stations. The table below summarizes the winners of the NOBCChE Percy L Julian Award: 57


FORUM AND WORKSHOP ABSTRACTS Year

Award Recipients

1975

Dr. Arnold Stancel (1) Mobil Oil Company

1977 1979

Dr. W. Lincoln Hawkins, Bell Laboratories Dr. William Lester, Lawrence Berkeley Laboratory

Year Award Recipients 1995 Dr. Joseph Francisco, Purdue University Dr. Edward Gay, Argonne National 1996 Laboratory 1997 Dr. James H. Porter , UV Technologies 1998 Dr. William A. Guillory, Innovations Consulting 1999 Dr. Linneaus Dorman, Dow Chemical Company 2001 John E. Hodge (5) (1914–96), U.S. Department of Agriculture, Peoria, IL 2001 James A. Harris (5) (1932–2000), Lawrence Berkeley Laboratory 2002 Dr. Victor McCrary, Johns Hopkins Applied Physics Laboratory 2003 Dr. Victor Atiemo‐Obeng, Dow Chemical Company

1981

Dr. James Mitchell (2), Bell Laboratories

1982

Dr. K.M. Maloney, Allied Corporation

1983

Dr. B.W. Turnquest, ARCO Petroleum

1985 1986

Dr. William Jackson, (3) Howard University Dr. George Reed, Argonne National Laboratory

1987

Dr. Reginald Mitchell, Stanford University

1988 1989

Dr. Isiah Warner (4), Emory University Dr. James C. Letton, Proctor & Gamble Company Dr. Theodore Williams, College of Wooster (Ohio)

2005 Dr. James H. Wyche, University of Miami

1991

Dr. Bertrand Frazier‐Reed, Duke University

2007 Dr. Kenneth Carter, UMass

1992

Dr. Willie May, NIST

2008 Dr. Sharon Haynie, DuPont

1993

Dr. Joseph Gordon, IBM

2009 Dr. Soni Olufemi Oyekan, Marathon Oil

1994

Dr. Dotsevi Y. Sogah, Cornell University

1990

2004 Dr. Gregory Robinson, University of Georgia

2006 Dr. Jimmie L. Williams, Corning Incorporated

References and recommended reading 1 2 3

NOBCChE’s Percy L Julian Award, http://www.nobcche.org/index.cfm?PageID=50174597-757C-432EBA8C253625586175&PageObjectID=37 Percy Julian, Wikipedia Encyclopedia, http://en.wikipedia.org/wiki/Percy_Julian Julian – Trail Blazer, Peter Tyson, http://www.pbs.org/wgbh/nova/julian/civil.html

58


FORUM AND WORKSHOP ABSTRACTS Tuesday, p.m.

PercyL Julian Luncheon Lecture 12:00 ‐ 1:30 p.m.

Landmark 1‐4

“Catalytic Applications For Enhanced Production Of Transportation Fuels”

Dr. Soni Olufemi Oyekan Marathon Oil

Oil refining companies produce clean transportation fuels to run the world’s economies via continuous use of innovative and efficient refinery processes. The reliable generation of gasoline blending components and hydrogen is a significant challenge for oil refiners. Hydrogen is required as a co‐reactant in Hydrotreating and Hydrocracking processes to produce clean gasoline, diesel and jet fuel. Fixed and moving bed catalytic reformers are key processes used by refiners to meet thirty percent of the gasoline demand and to produce aromatic compounds for the chemical industry and hydrogen for the production of low emission transportation fuels. A unique application of platinum catalysis for enhancing the production of gasoline and hydrogen will be discussed as well as overviews of an activation process for platinum containing catalysts and low sulfur naphtha reforming. The platinum rhenium catalytic studies discussed led to staged platinum/rhenium combo catalyst systems and a new platinum/rhenium catalysts nomenclature. Terms such as “equi‐molar”, “balanced” and “skewed” catalysts have become standard in oil refining. The novel platinum catalyst activation procedure is now in use in over 100 low pressure continuous catalyst regeneration units and the applications of the catalytic advancements discussed have possibly led to two to three percent increase in the barrels of transportation fuels produced worldwide

Tuesday, p.m.

The Chemistry of Forensic Science 1:45 p.m. ‐ 3:30 p.m Hosted by DEA/South Central Laboratory

Pershing

The DEA Forensic Laboratory System is one of the most respected crime laboratory systems in the world and continues to improve on its operations for of controlled substances, fingerprint and digital evidence. Our unique insight on these processes helps ensures that the results that are reported meet the scrutiny of the public and is scientifically correct. The scientific use of chemistry plays a very important role in the different disciplines within the DEA Forensic Laboratory System. This panel discussion will focus on some of those uses and how chemistry is an important part of our daily analysis.

59


FORUM AND WORKSHOP ABSTRACTS Tuesday, p.m.

Plenary III ‐ Health Symposium 4:00 p.m. ‐ 6:00 p.m. sponsored by Eli Lilly Company

Landmark 6‐7

“Diabetes in the African – American Community” Moderator: Presenters:

Dr. Ronald D. Lewis, II, Chair, 2008 NOBCChE Health Symposium St. Louis representatives from the ADA (American Diabetes Association)

As part of NOBCChE’s continuing effort to address health disparities within the African American community during our annual conference, we will focus on Diabetes at this year’s Health Symposium in St. Louis. Sadly, the numbers speak for themselves. African Americans continue to be disproportionately affected by this debilitating disease and the many complications associated with diabetes. In 2005, African Americans were 2.2 times than non‐Hispanic Whites to die from diabetes. Currently, African Americans are almost twice (1.9) as likely to be diagnosed with diabetes as non‐Hispanic whites by a physician. Additionally, African Americans are more likely to suffer complications from diabetes, such as end‐stage renal disease and lower extremity amputations. Some additional facts: In 2002, African American men were 2.1 times as likely to start treatment for end‐stage renal disease related to diabetes, as compared to non‐Hispanic white men. In 2003, diabetic African Americans were 1.7 times as likely as diabetic Whites to be hospitalized. Our panel will focus on current treatments, clinical advances, and advocacy efforts directed at eliminating this disparate disease. * Sources: The Office of Minority Health, Data and Statistics, Diabetes; http://www.omhrc.gov and references cited therein.

60


FORUM AND WORKSHOP ABSTRACTS

Wednesday, a.m., p.m.

Professional Development Workshop: Utilizing The STAR 9:00 a.m. ‐ 11:00 a.m. Kingsbury 1:00 p.m. ‐ 3:00 p.m. Guest Speaker ‐ Carolyn Greco President and CEO of THE FACET GROUP

Carolyn Grecoʹs presentation will expand upon career development as an organized approach to match employee goals with the business needs of an organization, which then support any workforce development initiatives. In this process, career development enhances each employeeʹs current job performance, enables individuals to take advantage of future job opportunities, and fulfills the organizationʹs goals for a dynamic and effective workforce. Managers are responsible for linking the organizationʹs needs to employee career goals, and can assist employees in the career planning process. The Human Resources function is responsible for designing career paths and employee development programs that help employees reach their goals, while each employee is responsible for planning and managing his/her career.

Wednesday, a.m.

NSF Graduate Research Fellowship Informational Session 9:00 a.m. ‐‐ 10:30 a.m. William Hahn, Ph.D. Program Director National Science Foundation

Pershing/Lindell

This workshop will discuss information on the NSF Graduate Research Fellowship Program, NSFʹs oldest program that has supported over 43,000 STEM graduate students since 1952. More descriptive materials may be found at our operations website, www.nsfgrfp.org. A question and answer session will follow the session. 61


FORUM AND WORKSHOP ABSTRACTS

Wednesday, a.m.

Professional Development Workshop “Lets Talk Graduate School” 11:15 a.m. ‐ 12:15 6. p.m.

Presenter

Landmark 6

G. Dale Wesson, Ph.D., PE Interim Vice President for Research Florida Agricultural and Mechanical University

Are you considering graduate school, but are concerned about the costs? Is graduate school the right choice for you? Should you first go to work before going to graduate school? How long does graduate school really take? How do I choose the right graduate school for me? This entertaining presentation attacks some of the most common misconceptions concerning graduate school for engineering and science majors. After attending this presentation, you will have straight answers to these and many other questions enabling you to make smart graduate school choices.

Wednesday, a.m.

“Academia: What Are Your Options” 9:00 a.m. ‐ 11:00 a.m. Isiah Warner, Ph.D. Department of Chemistry Louisiana State University

Landmark 6

Thursday, a.m.

Gregory Tew, Ph.D., Associate Professor, University of Massachusetts, Amherst

This workshop is designed to explore the various options for graduate students considering an academic career and faculty already in the early stages of an academic career. We will explore various job opportunities in academia, including tenure‐track and non tenure‐track academic positions. In addition, we will discuss the “do’s and don’t’s” of working toward tenure in a tenure‐ track position in small, medium, and large academic institutions. A question and answer session will follow the presentations at this workshop. 62


FORUM AND WORKSHOP ABSTRACTS

Wednesday, p.m. Presenter

“What It Takes To Find A Job” 1:30 – 3:30 p.m. Landmark 3 Nick Nikolaides, Ph.D. Manager, Doctoral Recruiting & University Relations The Procter & Gamble Company

In today’s competitive environment, looking for a job is quite often a full time job itself. Along with solid technical skills, employers are requiring that top candidates must also master many of the “soft” skills including leadership, collaboration, and communication. Attentive preparation of one’s resume, cover letters, and technical presentations to highlight these collective skills is absolutely essential. This presentation offers useful tips and suggestions to enhance one’s chances of “landing” that perfect job.

Thursday, a.m.

Plenary V: Alternate Energy Solutions Plenary Portland/Benton 8:00 a.m. ‐‐ 9:00 a.m. “Beyond Fossil Fuels: Nanostructured Materials For Hydrogen Production” Professor Levi T. Thompson Department of Chemical Engineering, Department of Mechanical Engineering, Hydrogen Energy Technology Laboratory

University of Michigan, Ann Arbor, MI sponsored by The Johns Hopkins Applied Physics Laboratory Securing our nation’s energy supply is arguably the most important challenge we face. The source and amount of energy that is available impacts nearly every aspect of our lives including our mobility, health and welfare. Presently, the U.S. depends heavily on foreign energy resources. For example, in 2008, nearly 60% of the crude oil consumed in the U.S. was imported; approximately one‐quarter of this oil comes from the Persian Gulf. With growing demands from emerging economies, declining environmental quality and potential for global conflict, there is a pressing need to develop a more sustainable energy strategy. Hydrogen has the highest energy density of any non‐nuclear fuel, can be easily converted to electrical and thermal energy via highly efficient, non‐ polluting processes, and is viewed as a key energy carrier for the future. Hydrogen is also an 63


FORUM AND WORKSHOP ABSTRACTS important reactant in the production of chemical and food products including fertilizers and is the ideal reductant for the recycle of CO2 into chemicals and fuels. Progress towards the production of hydrogen from renewable and carbon‐neutral sources will require the discovery and development of better performing catalytic and electrocatalytic materials. This presentation will briefly describe our efforts to design and synthesize high performance, nanostructured materials for the production of hydrogen using biomass derived products, water and solar energy.

Thursday, p.m.

“GEM Workshop: Why Graduate School?” 2:30 – 3:30 p.m. Marcus Huggans, Ph.D., Senior Recruiter and Programs Specialist, The National GEM Consortium, Notre Dame, IN

Kingsbury

This workshop will prove the fundamental belief of the 21st century and beyond: all STEM professionals should hold an advanced STEM degree. Particularly, the participants will gather information about career and financial implications of NOT obtaining a graduate degree. If you think all you need is a bachelors degree to competitive in the global society or that you should work first then go back to graduate school, YOU CANʹT MISS THIS WORKSHOP! Come find out why graduate school is not an option by necessity.

64


CONFERENCE SPEAKERS Monday, a.m.

Henry Hill Lecture 10:45 ‐ 11:50 a.m.

Landmark 6‐7

Richard S. Davis, Ph.D.

Head, BIPM Mass Section International Bureau of Weights and Measures Richard S. Davis received a bachelor’s degree in physics from Brown University in 1967 and a doctorate in solid state physics from the University of Maryland in 1972. Upon finishing his academic training, he joined the National Institute of Standards and Technology (NIST) as a post‐doc, where he helped to achieve what is still the most accurate electrochemical determination of the Faraday constant. This led to a permanent position in the mass calibrations group at NIST, where he remained until joining the International Bureau of Weights and Measures (BIPM) in 1990. Prior to leaving NIST, he collaborated on a new determination of the universal gas constant. Almost 20 years later, this is still the most accurate published result (though perhaps not for much longer). In 1993 Davis became head of the BIPM Mass Section, which is his current position. The BIPM is responsible for disseminating the kilogram unit to the Member States of the BIPM, as it has done since 1875. The BIPM, taking advantage of improved technology, is heavily committed to improving the definition and realization of the kilogram. This is reflected in the program of work within the Mass Section and internationally, through collaborations with national metrology institutes such as NIST. Davis is the author or co‐author of numerous scientific papers and is a Fellow of the American Physical Society.

65


CONFERENCE SPEAKERS

Monday, p.m.

Plenary I – New Developments in Denistry Materials Symposium 3:00 p.m. ‐ 4:00 p.m.

Landmark 6‐7

Nathan Fletcher, D.D.S.

Immediate Past President National Dental Association Dr. Fletcher was born in Washington, D.C. October 11, 1957. His family moved to Rockville, MD in 1969 and he graduated from Magruder High School of the Montgomery County, MD school system in 1975. He matriculated to Morgan State University that same year. Nathan was a chemistry major and Cooperative Education student working with Ford Motor Company in Dearborn, Michigan as a chemical researcher until he graduated Cum Laude in 1980 with a Bachelor of Science degree in Chemistry. He is a Life Member of the Morgan State University National Alumni Association. He was employed with Ford Motor Company for three years before entering the Howard University College of Dentistry in the summer of 1983. He earned honors while there on the College of Dentistry’s Dean’s List, the National Dean’s List, Who’s Who Among Students in American Universities and Colleges, and Outstanding Young Men of America. In 1987 Dr. Fletcher was bestowed the Doctor of Dental Surgery degree graduating 10th in his class. Dr. Fletcher is currently in private practice with his wife Dr. Alison Riddle‐Fletcher. He has been a Consultant in the Philadelphia Prison System as the Vice President for Operations with Mumby & Simmons Dental Consultants. He has also been a Consultant evaluating the statewide Pennsylvania Division of Corrections dental operations. He was employed as the Regional Chief Dentist for the Division of Corrections in Baltimore as well as the Baltimore County Detention Center totaling sixteen years in correctional dentistry. Dr. Fletcher is involved in organized Dentistry with the Maryland Dental Society, which is a component of the National Dental Association, serving as its President from 2003 through 2004. He is also a member of the Hispanic Dental Association. He was the 84th National President of the National Dental Association (NDA) serving for the year 2008. In that capacity he served as its spokesperson and the face of the NDA. He has been recognized as one of the Ebony Power 150 as an Organizational Leader in May 2008 and was featured in the July 2008 issue of Ebony with an article entitled “Taking Care of Your Smile Means a Better Healthier You.” He is included in the Baltimore Urban League’s 2008 publication The State of Black Baltimore writing on “The State of Oral Health Care of Baltimore City.” He has been interviewed for radio and several newspapers across the nation regarding the status of oral health 66


CONFERENCE SPEAKERS care in the black community and representing the NDA and its position on critical issues in dentistry. He testified for the NDA before the U.S. Food and Drug Administration Committee on Medical Devices in 2006. He was on the 2008 Congressional Black Caucus Health Braintrust Panel discussing the top five healthcare issues facing the Black community today. Dr. Fletcher also presented during the 2008 National Medical Association Colloquium on the Role of Dentists in Addressing Obesity in America. He was a panelist at the “NDA on the Hill” in 2006 discussing Public Policy Advocacy and has testified before committees in the House and Senate of the Maryland State Legislature.

Monday, p.m.

Opening Luncheon 12:00 – 1:30

Landmark 1‐4

Dr. Mark S. Wrighton Chancellor Washington University in St. louis St. Louis, MO

Mark S. Wrighton, Ph.D., was elected the 14th Chancellor of Washington University in St. Louis in 1995, and serves as its chief executive officer. In the years following his appointment, the University has made significant progress in student quality, campus improvements, resource development, curriculum, and international reputation. Born in Jacksonville, Florida in 1949, Wrighton received his B.S. degree with honors in chemistry from Florida State University in 1969. While at Florida State, he studied under Professor Jack Saltiel and upon graduation received the Monsanto Chemistry Award for outstanding research. He did his graduate work at the California Institute of Technology under Professors Harry B. Gray and George S. Hammond, receiving his Ph.D. there in 1972. His doctoral dissertation was on ʺPhotoprocesses in Metal‐Containing Molecules.ʺ He was named the first recipient of the Herbert Newby McCoy Award at Caltech based on his research accomplishments. He received an Honorary Doctor of Science Degree from the University of West Florida in 1983 and an Honorary Doctorate of Humane Letters from Florida State University in 2007. Chancellor Wrighton was the recipient of the Distinguished Alumni Award from Caltech in 1992. In 2002, he was named an Honorary Professor at Shandong University in Jinan, China. He has delivered commencement addresses at Caltech in 1995 and Florida State University in 2007. Wrighton started his career at MIT in 1972 as Assistant Professor of Chemistry. He was appointed Associate Professor in 1976 and Professor in 1977. From 1981 until 1989 he held the Frederick G. Keyes Chair in Chemistry. In 1989 he was appointed the first holder of the Ciba‐Geigy Chair in 67


CONFERENCE SPEAKERS Chemistry. He was Head of the Department of Chemistry from 1987‐1990 and became Provost of MIT in 1990, a post he held until the summer of 1995. Wrighton is the author or co‐author of more than 300 articles published in professional and scholarly journals, and he holds 14 patents. He has research interests in the areas of transition metal catalysis, photochemistry, surface chemistry, molecular electronics, and in photoprocesses at electrodes. Principal objectives of his research have been to elucidate the basic principles underlying the conversion of solar energy to chemical fuels and electricity, to discern new catalysts and ways of making them, to understand chemistry at interfaces, and to provide the knowledge base for development of new electro‐chemical devices. Wrighton has lectured widely on his research work and has given more than 40 named lectureships at distinguished colleges and universities in the United States and other countries. About 70 individuals received the Ph.D. degree under his supervision at MIT.

1:45 p.m. – 5:30 p.m. Lindell “The Chemistry of Leadership” Presented by Sandra Shullman

Monday p.m.

COACh Workshop

SANDRA L. SHULLMAN, Ph.D. S Dr. Shullman is Managing Partner, Columbus Office of the Executive Development Group, an international leadership development and consulting firm. She received her Ph.D. in counseling psychology from The Ohio State University. During that same time, Sandy was a co‐founder of the Women’s Studies Program at Ohio State. Dr. Shullman is a nationally known organizational consultant and has written and presented extensively on the topics of performance appraisal, performance management, strategic succession planning, career development, management of self‐esteem and motivation, team building, diversity management, and the management of individual, organizational and systems change strategies. She is well known for her work related to executive assessment and development and co‐authored Performance Appraisal on the Line.

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CONFERENCE SPEAKERS Monday, p.m.

Technical Session 1 1:45 p.m. – 2:15 p.m. 2009 Lloyd Ferguson Young Scientist Award Winner

Landmark 6‐7

Malika Jeffries‐EL, Ph.D. Assistant Professor Iowa State University Malika Jeffries‐EL took an interest in science after taking her first chemistry class at Brooklyn Technical High, an honors public high school in New York City. She then attended Wellesley College, where she completed a Bachelors degree in chemistry and the George Washington University (Washington, D.C.) where she obtained Masters and Doctorate degrees in organic and polymer chemistry, respectively. After a post‐doctoral fellowship under the supervision of Dr. Richard D. McCullough (Carnegie Mellon University), she joined the faculty in the Chemistry Department at Iowa State University. Her research efforts focus on the design and synthesis of conjugated polymers and the investigation of these materials for use in a number of applications (e.g. photovoltaic cells, field effect transistors and organic light emitting diodes). She has received two NOBCChE awards previously the Eastman Kodak Dr. Theophilus Sorrell Award in 2000 and the Agilent Professional Development Award in 2008. In addition, Malika has also received the Emerald Honors for most promising minority scientist (Science Spectrum Magazine), the Untenured Faculty Award (3M), the Gregory L. and Kathleen C. Geoffroy Faculty Fellowship, 2005‐2009 and NSF‐CAREER 2009‐2014.

Tuesday, a.m. Wednesday, a.m.

Teachers Workshop 7:00 a.m. ‐ 5:00 p.m.

Landmark 5

“Teachersʹ Embracing Science through Education” Sponsored by 3M AAAS, Roche Pharmaceuticals, and Committee for Action Program Services

Mrs. Linda Davis, Committee Action Program Services Linda L. Davis is founder and executive director of the Committee for Action Program Services (CAPS). CAPS is a non‐profit organization specializing in teacher’s professional development in science and technology. In addition, she provides science enrichment program for students in grades 4 through 12, such as field trips to Johnson Space Center ‐ Houston; facilitate overnight camps to Science Place, Fair Park in 69


CONFERENCE SPEAKERS Dallas, Texas. CAPS has collaborated with the Luna Planetary and Institute (LPI) and the Genesis Mission Program, a space science educational program through NASA on professional development workshops for science educators in Dallas, Texas . Mrs. Davis is the Administrator at Inspired Vision Academy I in Dallas, Texas. Her responsibilities include special program coordinator for science curriculum and enrichment programs; elementary advisor for test required programs; grant writer for the science department and community outreach programs, and coordinator/facilitator for staff development. Mrs. Davis holds a Bachelor of Science in Organizational Management from Paul Quinn College in Dallas, Texas.

DR. SAUNDRA YANCY McGUIRE Dr. Saundra Yancy McGuire is the Director of the Center for Academic Success, Adjunct Professor of Chemistry, and Associate Dean of University College at Louisiana State University in Baton Rouge, Louisiana. She received her B.S. degree, magna cum laude, from Southern University, Baton Rouge, LA; her M.A. from Cornell University, Ithaca, NY; and her Ph.D. in Chemical Education from the University of Tennessee at Knoxville, where she received the Chancellor’s Citation for Exceptional Professional Promise. Prior to joining LSU in August 1999, she spent eleven years at Cornell University, where she served as Director of the Center for Learning and Teaching and Senior Lecturer in the Department of Chemistry, and received the coveted Clark Distinguished Teaching Award. Dr. McGuire is the author of numerous publications, including the Problem Solving Guide and Workbook, Study Guide, and Instructorʹs Teaching Guide for Russo/Silverʹs Introductory Chemistry, Third Edition. She is the recipient of numerous awards. Her most awards include the 2007 Diversity Award from the Council on Chemical Research; the 2006 Presidential Award for Excellence in Science, Mathematics, and Engineering Mentoring, awarded by President Bush in an Oval Office Ceremony; the 2005 National Service Award and the 2002 Dr. Henry C. McBay Outstanding Chemistry Teacher Award, both presented by the National Organization for the Professional Advancement of Black Chemists and Chemical Engineers (NOBCChE); and the 2003, 2004, 2005, and 2007 Teaching in Higher Education Conference Outstanding Presentation Award. Additionally, she was designated a 2003 YWCA Woman of Achievement in the City of Baton Rouge, Louisiana. She is married to Dr. Stephen C. McGuire, and they are the parents of Dr. Carla Abena McGuire Davis and Dr. Stephanie Niyonu McGuire, and the grandparents of Joshua Bolurin, Ruth Anaya, Daniel Tabansi, and Joseph Olufemi Davis.

Ms. Yolanda George, American Association for the Advancement of Science Yolanda S. George is Deputy Director and Program Director for the Directorate for Education and Human Resources Programs (EHR) at the American Association for the Advancement of Science (AAAS). Her responsibilities include conceptualizing, developing, implementing, planning, and 70


CONFERENCE SPEAKERS directing multi‐year intervention and research projects related to increasing the participation of minorities, women, and disabled persons in science and engineering. Her recent K‐12 mathematics and science reform work includes contributing to the development of materials for infusing equity into systemic reforms and conducting research on how state departments of education and school districts are aligning equity and science and math initiatives. Also, she has conducted equity reviews for textbooks and software publishers and test developers, including New Standards Science. She serves as a consultant to numerous federal and state agencies, foundations and corporations, and colleges and universities including the National Science Foundation, the U.S. Department of Education, Carnegie Corporation of New York, the New Jersey State Department of Education, and the Louisiana State Department of Education, and serves on several advisory boards including the National Academy of Engineering Committee on Women in Engineering, California State University, Los Angeles Access Project, and WGBH Instructional Television Science Project and others.

Mr. Gerald W. McElvy, President, Exxon Mobil Foundation, Dallas, Texas Gerald W. McElvy is President of the ExxonMobil Foundation, the primary philanthropic arm of Exxon Mobil Corporation. The Foundation’s focus areas include math and science education, fighting malaria and other infectious diseases, empowering women and girls in developing countries, public policy, and civic and community programs in regions where ExxonMobil has significant operations. Mr. McElvy has been employed by ExxonMobil for more than 31 years and has extensive financial and general management experience. Prior to assuming his current responsibilities, he served as Europe downstream planning manager for Exxon Company International, finance director and controller of Esso Australia, upstream controller of Exxon Mobil Production Company, U.S.A., and general auditor of Exxon Mobil Corporation. Mr. McElvy is a Trustee of the Eisenhower Fellowships, which sponsors U.S. internships for emerging global leaders. He also serves on the Executive Advisory Council at the University of Houstonʹs Bauer College of Business and is a board member of the University of Houston Alumni Association. He is a board member of Reasoning Mind, an innovative, web‐based middle school math program focused on improving math education and closing the achievement gap; and was recently appointed to the Board of the Texas Academy of Math and Science based at the University of North Texas. He is a member of Financial Executives International, the American Institute of Certified Public Accountants, and the Executive Leadership Council. He has previously served as a board member of several education and community service organizations including the Texas Business and Education Coalition, Kappa Alpha Psi Foundation, the United Way of Texas Gulf Coast, Save the Tiger Council, Friends of Hermann Park, and Odyssey House, a chemical dependency recovery program for adolescents in Houston. Mr. McElvy is a native of Ft. Worth, Texas. He earned a BBA degree in Economics and Accounting in 1975 from the University of Houston and completed an MBA in Finance from UCLA in 1977. 71


CONFERENCE SPEAKERS

JAMES GRAINGER, PhD, Analytical/Environmental Chemist, Center for Disease Control and Preventive Dr James Grainger is an analytical/environmental chemist at the Centers for Disease Control and Prevention in Atlanta, currently responsible for the PAH Adducts Group in the National Center for Environmental Health. Primary projects include development of new analytical methods for extending analytical exposure windows for organic environmental toxicants through human exposure profiles of DNA, serum albumin and hemoglobin adducts. Born in South Carolina, he received a BS in chemistry from South Carolina State College, a MS degree in physical/organic chemistry from Atlanta University, and a PhD in polymer/organic chemistry from Atlanta University. Dr Grainger has developed and presented a variety of talks on African origins of mathematics, science and technology, developing a multidisciplinary course on a chemistry platform entitled Prehistoric Future Chemistry I. The course examines the development of art, mathematics, science and technology in five river civilizations from the Stone Age to the Iron Age and was taught for two years at Spelman College. Dr Grainger currently serves as NOBCChE Southeast Regional Chair. Central to his variety of interests are family interactions with wife, Barbara, daughter Adrienne, son Daren and grandchildren AJ and Ari.

Tuesday, a.m.

Plenary II ‐ Biotechnology Symposium 8:30 a.m. ‐ 9:30 a.m.

Portland/ Benton

Squire J. Booker, Ph.D. Associate Professor Pennsylvania State University Squire J. Booker was raised in Beaumont, Texas, where he got excited about science during frequent trips as an elementary school student to NASA in Houston with his Uncle, Albert J. Price. He received a BA degree with a concentration in Chemistry from Austin College (Sherman, Texas) in 1987. In the summer of 1986 he participated in the first MIT Minority Summer Science Research Program, where he worked in the laboratory of the late Dr. William H. Orme‐Johnson in the Department of Chemistry. He earned his Ph.D. degree from the Massachusetts Institute of Technology with Professor JoAnne Stubbe (1994), 72


CONFERENCE SPEAKERS and was supported by NSF–NATO and NIH Fellowships for postdoctoral studies in the laboratories of Dr. Daniel Mansuy (Université René Descartes, Paris, France) and Professor Perry Frey (Institute for Enzyme Research, University of Wisconsin–Madison), respectively. In 1999 he moved to The Pennsylvania State University as an independent investigator, where he is currently an Associate Professor of Chemistry, and an Associate Professor of Biochemistry and Molecular Biology. Dr. Booker is a former Minnie Stevens Piper Fellow, and has received numerous other awards, which include the George T. Landolt Memorial Fellowship in Chemistry, the P. S. Wharton memorial Fellowship in Chemistry, the American Chemical Society Outstanding Student Award (local chapter), NSF Faculty Early Career Award, and the Presidential Early Career Award in Science and Engineering. In addition to other national service, Dr. Booker served as co‐chair for the Gordon Conference on Enzymes, Co‐enzymes, and Metabolic Pathways (2007), and is currently serving on the Minority Affairs Committee for the American Society of Biochemistry and Molecular Biology, Dr. Booker’s research is concerned with novel mechanisms and pathways for the biosynthesis of natural products and metabolites, as well as the involvement of metal ions and metal clusters in enzyme catalysis. One pathway of particular focus is the biosynthesis of the cofactor and antioxidant, lipoic acid.

Tuesday, a.m.

Technical Session 5 9:45 – 11:45 a.m. Dr. Henry McBay Outstanding Teacher Award Winner

Aubert

Shawn Abernathy, Ph.D. Associate Professor Howard University Dr. Shawn M. Abernathy is an Associate Professor in Chemistry at Howard University. He is a physical chemist and currently teaches undergraduate and graduate courses in physical chemistry. His area of expertise is in experimental NMR spectroscopy and Dr. Abernathy uses numerous NMR techniques in his research. He has successfully utilized conventional NMR and a NMR micro‐probe to elucidate the dioxin 2, 3, 7, 8 – tetrachlorodibenzo‐p‐dioxin (TCDD) spiked into the oil and fat salmon and meat products; this work was done in collaboration with Dr. Roberto Gill the director of Carnegie Mellon University (CMU) Department of Chemistry NMR facility. He has used NMR to perform T1 and T2 relaxation experiments on transition metal complexes with 73


CONFERENCE SPEAKERS spins S=1 and S=3/2. Over the past two years, Dr. Abernathy has been conducting collaborative research with Dr. James Wishart of Brookhaven National Laboratory Department of Chemistry performing NMR diffusion measurements on various ionic liquids (IL’s) and has prepared IL samples for kinetic studies on BNL Laser Electron Accelerator Facility (LEAF). During the summer of 2007, Shawn provided his expertise in NMR to make available the capability to perform NMR diffusion experiments on BNL 400 MHz NMR. Dr. Abernathy is the director of Howard University Department of Chemistry NMR user facility. In 2002, he supervised the renovation, upgrade of the NMR laboratory, installation of a 400 MHz NMR spectrometer, and wrote an instruction manuel for operating the instrument. He is the first Howard University faculty member to participate in the BNL faculty student team (FAST) program. Recently, Shawn has worked along with BNL Office of Educational Programs (OEP) in conducting their 2009 Mini‐semester Program that focused on ionic liquids (IL) research. Dr. Abernathy has offered his professional service on a board and several committees as well as in the community. He is a member of the Howard University BWHR (Baltimore Washington Hampton Roads) LS‐AMP (Louis‐Stokes‐Alliance for Minority Participation) Program Board of Governors under the directorship of Dr. Clarence M. Lee. He is on the advisory committees of the Benjamin Banneker Institute for Science and Technology and Howard University Black Excellence in Science/Math Teaching (BEST) Education Research Project, which is part of the Historically Black Colleges and Universities Program (HBCU‐UP) sponsored by NSF. He has taught pre‐freshmen chemistry in the Howard University Science Engineering and Mathematics (HUSEM) Program. He has served as a judge for NOBCChE poster and undergraduate oral presentation competition. Shawn has served as an NSF panel reviewer of NMR proposals (2002 and 2006) and a reviewer of general chemistry textbooks for the Wiley Publishing Co., Inc. He is a member of NOBCChE, ACS, Sigma Xi honor society, and Omega Psi Phi Fraternity, Inc. Shawn is also on the football coaching staff at Springbrook High School in Silver Spring, Maryland. He coaches receivers and outside linebackers for the junior varsity football team. Dr. Abernathy is a graduate of the University of Michigan at Ann Arbor. He received his BS in chemistry, MS in inorganic chemistry (Dr. BJ Evans), and Ph.D. in physical chemistry (Dr. Robert Sharp). He was a postdoctoral research associate in the Biomedical NMR Laboratory of Dr. Paul C. Wang of the Department of Radiology in Howard University Cancer Center. Shawn also conducted research at the Howard University Beltsville Research Laboratory conducting x‐ray diffraction and synchrotron radiation experiments on plastics at Argonne National Laboratory. 74


CONFERENCE SPEAKERS Tuesday, p.m.

Percy L. Julian Luncheon 12:00 – 1:15 p.m.

Landmark 1‐4

Dr. Soni Olufemi Oyekan

Reforming and Isomerization Technologist Marathon Oil

Dr. Soni Olufemi Oyekan is the Reforming & Isomerization Technologist for Marathon Oil with wide ranging technical, engineering and management responsibilities for Marathon’s seven oil refineries. Soni Oyekan holds 2 US patents and 8 foreign patents earned in the first 7 years of research and development work in catalytic reforming technologies before moving into refining technology support and management for DuPont, Sunoco, Amoco, BP and Marathon. A most significant innovation, in collaboration with George Swan, led to Exxon’s KX‐160 and KX‐120/KX‐160 catalytic reforming catalyst systems in the early 1980s and the concept of staging reforming catalysts to maximize gasoline blending component and hydrogen production in semi and cyclic regenerative reforming units. Staged catalyst systems are now used widely in the oil refining industry for achieving high gasoline component and hydrogen production in semi and cyclic regenerative reformers. Oyekan’s second significant invention of two stage reduction of platinum/promoter catalysts has been incorporated into two major continuous catalyst regenerative reforming processes. This is now used in over 100 continuous catalyst regeneration reforming units worldwide for maximizing the production of gasoline and hydrogen. In addition to catalytic reforming, Dr. Oyekan has contributed extensively in oil refining processes such as paraffin isomerization, xylene isomerization, selective hydrogenation, toluene disproportionation, fluid catalytic cracking, hydrotreating, hydrocracking and sulfur guard bed technology. He is also an expert in the management of precious metal systems. He led precious metals programs for platinum and silver management for Sunoco and Amoco leading to savings of millions of dollars for the companies in the 1990s. Soni received the BS degree in Engineering and Applied Sciences in 1970 at Yale University. He earned the MS at Carnegie Mellon University in 1972 and a Ph.D in chemical engineering from Carnegie Mellon University in 1977. He was made a member of Sigma Xi and Phi Kappa Phi honor societies in 1977. He was also given a North American Catalysis Society award for outstanding graduate students in 1977. Dr. Oyekan has worked in a variety of university academic programs for underprivileged students where he had special opportunities to teach and mentor hundreds of students. He taught physical sciences in the University Community Education Programs (UCEP) and chemistry in the Pittsburgh Engineering Impact Program (PIP) at the University of Pittsburgh 75


CONFERENCE SPEAKERS between 1972 and 1977. Dr Oyekan taught organic chemistry at the Allegheny Community College in Pittsburgh in 1974 and a petroleum refining course in 1984 at the New Jersey Institute of Technology in 1984. He collaborated with Dr. Stuart Shih and Peter Kokayeff to teach the “Catalytic Processes in Petroleum Refining” course between 1992 and 1997 in the AIChE Continuing Education Program. Dr. Oyekan is a member of the National Organization of Black Chemists and Chemical Engineers (NOBCChE) and an AIChE Fellow. He is a past chair of Fuels and Petrochemicals Division (F&PD) and the Minority affairs Committee (MAC). He has been recipient of the distinguished services awards from MAC and F&PD. He is the 2008 recipient of the AIChE MAC William Grimes award and was chosen as one of nine “Black Eminent Chemical Engineers” at the AIChE Centennial in 2008. He is a past member of the AIChE Board of Directors and a member of the AIChE Foundation Board of Trustees. He is married to Priscilla and they have three daughters, one son and two grandsons.

Wednesday, a.m.

“Academia: What Are Your Options” 9:00 a.m. ‐ 11:00 a.m. Isiah Warner, Ph.D. Department of Chemistry Louisiana State University

Landmark 6

Isiah M. Warner was born in DeQuincy, Louisiana on July 20, 1946. He graduated as Valedictorian of his high school class in 1964. He graduated Cum Laude from Southern University with a B.S. Degree in 1968. After working for Battelle Northwest in Richland, Washington for five years, he attended graduate school in chemistry at the University of Washington, receiving his PhD in analytical chemistry in June 1977. He was an assistant professor of chemistry at Texas A&M University from 1977 to 1982. He was awarded tenure and promotion to associate professor in 1982. However, he elected to join the faculty of Emory University as associate professor and was promoted to full professor in 1986. Dr. Warner was named to an endowed chair at Emory University in 1987, and was the Samuel Candler Dobbs Professor of Chemistry until he left in 1992. During the 1988/89 academic year, he was on leave to the National Science Foundation (NSF) as Program Officer for Analytical and Surface Chemistry. In August 1992, Dr. Warner joined Louisiana State University as Philip W. West Professor of Analytical and Environmental Chemistry. He was Chair of the Chemistry

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CONFERENCE SPEAKERS Department from July 1994‐97, and was appointed Boyd Professor of the LSU System in July 2000. In April 2001, Dr. Warner was appointed the Vice Chancellor for Strategic Initiatives. The primary research emphasis of Dr. Warnerʹs research group is the development and application of improved methodology (chemical, mathematical, and instrumental) for studies of complex chemical systems. His research interests include (1) fluorescence spectroscopy, (2) guest/host interactions, (3) studies in organized media, (4) spectroscopic applications of multichannel detectors, (5) chromatography, (6) environmental analyses and (7) mathematical analyses and interpretation of chemical data using chemometrics (chemical data analysis techniques). Dr. Warner has more than 230 published or in‐press articles in refereed journals since 1975. He has given more than 400 invited talks since 1979. He also has 5 US patents, and he has one other patent pending. He has chaired thirty‐one doctoral theses since 1982 and is currently supervising thirteen Ph.D. theses. Over the years, he has received many awards recognizing his scientific and mentoring efforts, including the NOBCChE Percy L. Julian Award in 1988, NOBCChE Outstanding Teacher Award in 1993, and the ACS Award for Encouraging Disadvantaged Student into the Sciences in 2003

Wednesday, a.m.

Professional Development Workshop: Utilizing The STAR 9:00 a.m. ‐ 11:00 a.m. 1:00 p.m. – 3:00 p.m. Guest Speaker ‐ Carolyn Greco President and CEO of THE FACET GROUP

Kingsbury

Carolyn Greco, President and CEO of THE FACET GROUP, has over 20 years of comprehensive experience in workplace consulting, career development and leadership training in a variety of applied settings. She earned a B.A. in Education with honors from Slippery Rock University in Pennsylvania in 1970 and an M.A. from the University of Louisiana in 1976. Prior to starting FACET in 1979, Carolyn began her professional career in secondary and university level education. She served as Project Director to a Fortune 50 energy company with P & L and operations responsibility for a network of nationwide career centers. She directed project sites in Atlanta, Seattle and Houston as well as a corporate headquarter site in San Francisco. She has extensive experience in the energy industry with a comprehensive background consulting to health care, finance, chemical, telecommunications and manufacturing. In 1990, she received the Governor Small Business Award for the State of Louisiana. Carolyn specializes in working with corporate clients who have achieved success and are now focusing on fulfillment. She is highly recognized for her expertise and innovation in the creation, delivery and administration of career management and workplace programs and services. Her 77


CONFERENCE SPEAKERS current practice includes individualized career strategies and refocusing, management intervention/coaching and leadership training. Specialized training is from New York Columbia University, in Organizational Development, the John F. Kennedy Institute for Career Development in Orinda, CA and the NTL Institute for Applied Behavioral Science in Bethel, ME. Carolyn is certified in the Birkman Method, Strong Interest Inventory and the Myers‐Briggs Type Indicator. Carolyn is a Board Member of the Association of Career Firms, North America Chapter.

Wednesday, a.m.

NSF Graduate Research Fellowship Informational Session 9:00 a.m. ‐‐ 10:30 a.m. William Hahn, Ph.D. Program Director National Science Foundation

Pershing/Lindell

William Hahn, Ph.D.

Program Director National Science Foundation William Hahn received his BA in Biology from Washington University in St. Louis, then after a stint in the Peace Corps (Paraguay), received an MSc in Botany from Cornell University. After that he spent two years in the Guianas working for the Smithsonian Institution before pursuing his PhD at the University of Wisconsin, Madison. Following an NSF Postdoctoral Fellowship at the Smithsonian, he was Assistant, then Associate Professor of Environmental Biology at Columbia University until 2003. From there he moved to Georgetown University as Associate Dean and is currently on leave to the National Science Foundation where he is the Program Director for the Graduate Research Fellowship Program. Dr. Hahnʹs research considers plant molecular evolution and conservation biology with special emphasis on the palms. 78


CONFERENCE SPEAKERS

Professional Development Workshop “Lets Talk Graduate School” 11:15 a.m. ‐ 12:15 6. p.m.

Wednesday, a.m.

Landmark 6

Presenter

G. Dale Wesson, Ph.D., PE Interim Vice President for Research Florida Agricultural and Mechanical University See Technical Session 12 for Biographical information

Wednesday, p.m.

“What It Takes To Find A Job” 1:30 – 3:30 p.m.

Landmark 3

Nick Nikolaides, Ph.D. Manager, Doctoral Recruiting and University Relations The Procter and Gamble Company Dr. Nikolaides received his Ph.D. in Synthetic Organic Chemistry in 1989 from Cornell University under the direction of Professor Bruce Ganem. After a Postdoctoral Fellowship with Professor Gary H. Posner at The Johns Hopkins University, Dr. Nikolaides accepted employment at 3M Pharmaceuticals in their Drug Discovery group. While at 3M, he contributed towards the design and synthesis of immune response modifiers as antiviral agents. He then moved to Procter & Gamble Pharmaceuticals in 1994, where he spent the better part of 14 years in drug discovery targeting cardiovascular indications, creating and leading a late discovery/early development custom chemistry & scale‐up group, and more recently establishing a Competitive & Technical Intelligence function for P&G Global Health Care. He currently manages Procter & Gamble’s Doctoral Recruiting & University Relations efforts and is a key player in expanding P&G’s open innovation “Connect + Develop” business model.

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CONFERENCE SPEAKERS

Thursday, a.m.

Plenary V: Alternate Energy Solutions Plenary 8:00 a.m. ‐‐ 9:00 a.m. “New Lithium Battery Technology”

Portland/Benton

Levi T. Thompson, Ph.D. Richard E. Balzhiser Professor of Chemical Engineering Professor of Mechanical Engineering Director, Hydrogen Energy TechnologyLaboratory The University of Michigan

Professor Thompson is the Richard E. Balzhiser Professor of Chemical Engineering, Professor of Mechanical Engineering and Director of the Hydrogen Energy Technology Laboratory. He earned his B.ChE. from the University of Delaware, and M.S.E. degrees in Chemical Engineering and Nuclear Engineering, and a Ph.D. in Chemical Engineering from the University of Michigan. Research in his group focuses primarily on the design, characterization and development of nanostructured catalytic, electrocatalytic and adsorbent materials. Technological applications for the work include hydrogen production from carbon neutral resources, fuel cells and batteries. From 2001 to 2005, he served as Associate Dean for Undergraduate Education in the College of Engineering and presently is Director of the Michigan‐Louis Stokes Alliance for Minority Participation. Professor Thompson is recipient of a 2006 Michiganian of the Year Award for his research, entrepreneurship, and recruitment and mentoring of minority students, National Science Foundation Presidential Young Investigator Award, Engineering Society of Detroit Gold Award, Union Carbide Innovation Recognition Award and Dow Chemical Good Teaching Award. He is also co‐founder, with his wife, of T/J Technologies, a developer of nanomaterials for advanced batteries and subsidiary of A123Systems. Professor Thompson is Consulting Editor for the AIChE Journal, and member of the External Advisory Committee for the Center of Advanced Materials for Purification of Water with Systems (NSF Science and Technology Center at the University of Illinois), National Academy’s Chemical Sciences Roundtable, and AIChE Chemical Engineering Technology Operating Council.

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CONFERENCE SPEAKERS

Thursday a.m.

Professional Development Workshop 9:00 a.m. ‐‐ 11:00 a.m. Academia: What Are your Options (pt 2)

Kingsbury

Gregory Tew, Ph.D., Associate Professor, University of Massachusetts, Amherst Greg was born in North Carolina and attended North Carolina State University where he earned a B.S. in Chemistry in 1995, graduating with honors. During this time he worked at the University with Prof. D. A. Shultz performing undergraduate research on self‐assembled monolayers containing stable free radicals and at Glaxo, formerly Burroughs‐Wellcome working on cardiovascular therapies. Upon graduation, he attended the University of Illinois‐Urbana to pursue graduate studies with Prof. Sam Stupp. His work on self‐assembling rod‐coil molecules lead to an understanding of the important molecular structures and association energies governing nanostructure formation. While in graduate school, his work was recognized by two fellowship awards including the Beckman Research fellowship and American Chemical Society Organic Division Fellowship in 1998 and 1999, respectively. After graduating in 2000, he joined Prof. William DeGrado’s laboratory at the University of Pennsylvania in Biochemistry and Biophysics were he spent one year studying biomimetic principles leading to several publications and the formation of a new company. In 2001, he started his faculty position in Polymer Science and Engineering at the University of Massachusetts, Amherst. His research interests include Supramolecular polymer science, bioinspired and biomimetic structures, polymers for biomedical science, self organization, well defined macromolecular architectures, functional materials, novel biomaterials, hydrogels.

Thursday, p.m.

GEM Workshop 2:30 – 3:30 p.m. ʺ Why Graduate School?ʺ

Kingsbury

Marcus Huggans, Ph.D.

Senior Recruiter/Programming Specialist The National GEM Consortium Notre Dame, IN Marcus Huggans, Ph.D., is a native of St. Louis, Missouri. He was educated in the University City and Lutheran Parochial school systems. He graduated 81


CONFERENCE SPEAKERS in 1991 from Lutheran High School North. Marcus completed his engineering studies at the University of Missouri‐Rolla. He received a BS degree in Electrical Engineering in 96, an MS in Engineering Management in 97 and a Ph.D. in Engineering Management in 98. He was one of the first African‐American males to earn a Ph.D. in this discipline from the University. For his Ph. D. dissertation, Huggans conducted a study to determine if different Internet‐based study aids helped students of different learning styles under the advisors Dr. Halvard E. Nystrom and Dr. Harvest L. Collier. The title of his dissertation was “The Impact of Learning Styles Using Web‐based Asynchronous Distance Learning to Enhance Instruction by Electrical Engineering Students.” His findings indicate that not everyone thinks and learns in the same way and being aware of the variations in learning styles can help professors improve their teaching environment and students test scores. Marcus conducted his research as a GEM fellow through the National Consortium for Graduate Degrees for Minorities in Engineering and Science Inc, sponsored by Texas Instruments. Dr. Huggans has had a variety of job opportunities. He has worked for 3M Company, AT&T Bell Laboratories, Department of Justice‐Federal Bureau of Investigation (FBI), and Texas Instruments Inc (TI). He began his professional career at TI in 1996 as an intern in the Digital Light Processing Group where he was a software engineer. Marcus developed C algorithms to test the color integrity of DMD projectors to enable them to handle hue transitions. In December of 1998, Marcus joined TI full‐time as a member of the Technical Sales Associate program. He has worked in Technical Training Organization (TTO) developing technical workshops for Digital Signal Processors (DSP) customer and catalog products. He has also worked as a Technical Information Specialist in the Product Information Center (PIC) supporting customers worldwide. Dr. Huggans transitioned from Technical Sales to Strategic Marketing/New Product Development for the PanelBus Division in May 2000 where he helped evaluate and influence TI’s next generation features that will power display technologies like HDTVʹs, LCD Monitors, and Digital CRTs. Finally at TI, he worked in an applications engineering role for four years evaluating consumer electronics and multi‐media IEEE 1394 products and supporting US and international customers. Dr. Huggans ran his own real estate company while teaching Marketing, Management, and Mathematics at the University of Phoenix. Dr. Huggans also worked at the University of Missouri‐ Rolla (UMR) as the Director of the Student Diversity and Academic Support Program. Under his leadership, UMR has experienced unprecedented growth in the recruitment of under‐represented minorities’ students in the areas of science and engineering. Currently, he works for the National GEM Consortium (GEM) under the direction of Ms. Michele Lezama. At GEM, Dr. Huggans recruits and conducts programming to encourage under‐represented minority students to pursue their graduate degrees in science, technology, engineering, and applied mathematics (STEM) fields. Currently, Dr. Huggans resides in Dallas, TX where he is happily married to his lovely wife Melanie, and he is a proud father of his daughter Hannah and son Ellis. In his spare time, he enjoys attending church, working with elementary, high school, and college students, and studying various investment vehicles. He also enjoys real estate investing, stocks and options, and entrepreneurship. Dr. Huggans believes that all individuals need to take control of their financial future. It is not the vehicle that will make you financially independent; it is the dedication to it.

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CONFERENCE SPEAKERS Thursday, p.m.

Technical Session 12 3:00 p.m. – 5:00 p.m. NOBCChE Professional Chemical Engineering Awardee

Parkview

G. Dale Wesson, Ph.D., PE Interim Vice President for Research Florida A&M University Dr. Wesson is currently the Interim Vice President for Research at Florida A&M University. His is also has a joint appointment as Associate Professor in the Biological and Agricultural Systems Engineering (BASE) Program at Florida A&M University and an Associate Professor in the Department of Chemical Engineering at the FAMU‐FSU College of Engineering. Dr. Wesson received his Bachelor of Science degree from the Illinois Institute of Technology, his Masters of Science degree from the Georgia Institute of Technology and his Doctor of Philosophy from Michigan State University, all in the area of chemical engineering. He has over nine years of industrial experience at the Dow Chemical Company and is a registered professional engineer in the states of Michigan and Florida. Dr. Wesson’s research interests are in the area of computational fluid dynamics of confined swirling flows. His current research projects include modeling of blood flow through heart valves and coronary arteries and the heat transfer within graphite foam matrixes. Dr. Wesson has over 50‐ combined research publications and presentations and over $3.0 million of funded research projects. In December of 2001, Dr. Wesson graduated the first Chemical Engineering Ph.D. student at Florida A & M University – Dr. Shannon Grady. Dr. Wesson was also awarded the “Dr. Henry C. McBay Outstanding Teacher Award” by the National Organization for the Professional Advancement of Black Chemists and Chemical Engineers (NOBCChE). Dr. Wesson was a GEM fellow while pursuing his Masters of Science in chemical engineering at Georgia Tech. The American Institute of Chemical Engineering (AIChE) honored Dr. Wesson as an Eminent Black Chemical Engineer at the 100th anniversary annual meeting in November 2008.

83


Claflin University The World Needs Visionaries DEPARTMENT OF CHEMISTRY Claflin University’s Department of Chemistry offers undergraduate students stateof-the-art research and instrumentation and courses in all major areas of chemistry. The department boasts many distinctions which are nationally recognized. Our eminent faculty holds outstanding teaching and research credentials from America’s top research institutions. The department’s students are the recipients of national research and outreach awards. Upon graduation 85% of the Claflin University’s chemistry students attend graduate school or join STEM workforce.

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TECHNICAL ABSTRACTS Monday, a.m.

Technical Session 1 4:00 – 6:00 p.m. Landmark 6‐7 Lloyd Ferguson Young Scientist Award Symposium – Materials Chemistry

Sibrina Collins, Ph.D. Department of Chemistry, The College of Wooster Presenters 4:15 p.m. – 4:55 Lloyd Ferguson Young Scientist Awardee “Synthesis Of Novel Conjugated Polymers Based On Benzobisoxazoles” p.m. Jared F. Mike, Andrew J. Makowski and Malika Jeffries‐EL* Department of Chemistry, Iowa State University, Ames IA 50011 Abstract Polybenzobisoxazoles posses many exceptional electronic, optical and thermal properties and thus are ideally suited for diverse organic semiconducting applications, yet these materials have found limited utility due their lack of solubility in organic solvents. A promising approach for the synthesis of soluble organic semiconductors is the combination of the benzobisoxazole moiety with substituted aromatic rings. However, the harsh conditions required for the synthesis of benzobisoxazoles has prevented the synthesis of benzobisoxazoles bearing reactive handles. Typically, benzobisoxazoles are synthesized via condensation reactions, in acidic mediums at high temperatures. Recently we have developed a new approach for the synthesis of optoelectronic building blocks based on benzo[1,2‐d;4,5‐dʹ] bisoxazoles (trans‐BBO) and benzo[1,2‐d;5,4‐dʹ] bisoxazoles (cis‐BBO) via the Lewis acid catalyzed reaction of various orthoesters with 2,5‐ diamino‐ hydroquinone and 4,6‐diaminoresorcinol respectively. In all cases the target compounds were obtained cleanly and in high yield. Subsequent transformations yield several building blocks suitable for coupling with aryl compounds via a variety of methods. The utility of these compounds as building blocks for the synthesis of novel, soluble polybenzobisazoles is demonstrated. The impact of structural modification on the optical, electronic and physical properties of the resulting polymers will be presented.

Session Chair

R N

N Y

Y O

O

O cis-BBO

Ar

Z

Y

Z

O

trans-BBO

N

O

O

Ar

R Ar

+ Z

N

n

R

N

Y N

+ Z

O

N

N

O

Ar n

R

85


TECHNICAL ABSTRACTS 4:55 p.m. – 5:15 p.m.

“Novel Precursor Design For The MOCVD Of Metal Oxides And Metal Nitrides”

Felicia A. McClary, Jason S. Matthews* Howard University, Department of Chemistry, Washington DC, 20059, USA Abstract Careful precursor selection allows for the growth of high purity thin films via MOCVD. We previously utilized a novel zinc bis‐β‐enaminoesterate to grow ZnO films which contained significantly less carbon than that which was grown from the analogous zinc‐β‐ketoiminates. More recently; we have developed new precursors for indium and gallium nitride by reacting a series of primary amines with chlorosilanes to afford the desired silylamine. The isolated products were purified via distillation and subsequently reacted with butyllithium to afford the lithium silylamide. The metathesis reaction of the lithium silylamide with chlorides of gallium and indium resulted in the formation of the precursors suitable for the MOCVD growth of metal‐nitrides. In addition, precursors utilizing secondary amines with triethylgallium were prepared. The isolated products were characterized via NMR, and FT‐IR and the X‐ray crystal structure deduced. Precursor volatility will be assessed via TGA. 5:15 p.m. – 5:35 p.m.

“Renewable Biomass Derived Polyolefins” Rennisha R. Wickham, Jia Wei, Lawrence R. Sita* Department of Chemistry and Biochemistry University of Maryland, College Park, MD 20742

Abstract The synthesis of new polymeric materials through the living homopolymerization, copolymerization and coordinative chain transfer copolymerization (CCTP) of (‐)‐β‐citronellene has been investigated in the presence of {Cp*Zr(Me)2‐[N(tBu)C(Me)N(Et)]}[B(C6F5)]4 (1) {Cp*Hf(Me)2[N(Et)C(Me)N(Et)]}[B(C6F5)] (2), or {CpZr(Me)2[N(Cy)C(Me)N(Cy)]}[B(C6F5)]4 (3) where (Cp* = η5‐C5Me5; Cp = η5‐C5; Cy = dicyclohexyl) catalysts as a function of temperature. β‐ citronellene is a non‐conjugated diene derived from the hydrogenation and cracking of α‐pinene; a diterpene, available at an industrial scale. The resulting polymers were characterized via GPC, DSC, 1D and 2D 1H NMR and 13C NMR spectroscopy. Catalyst dependent changes in the melting point and the molecular weight of homopolymers were observed. Copolymerization and CCTP of β‐citronellene with ethylene produced plastomers with percent incorporations of β‐citronellene ranging from 2‐11 mol%. 86


TECHNICAL ABSTRACTS Finally, this work has explored the utility of CCTP, employing multiple equivalents of diethylzinc as a means to scale production of these novel copolymers. This newly gained control coupled with the use of renewable non‐conjugated polyolefins can enable the expansion and versatility of the range of plastics, plasticizers, oils, and elastomers derived from monomers derived from renewable biomass feedstock. “Crystal Engineering Of Metal‐Organic Frameworks” 5:35 p.m. – 6:00 p.m. Sibrina N. Collins 1*, Roland Falcon1, Jeanette A. Krause 2,3, and William Connick2

College of Wooster, Department of Chemistry, Wooster, OH 44691 University of Cincinnati, Department of Chemistry, Cincinnati, OH 45221 3Richard C. Elder X‐ray Crystallography Facility, University of Cincinnati, Cincinnati, OH 45221 1

2

Abstract Metal‐organic frameworks (MOFs) remain a popular area of interest for potential applications of fuel storage. Three metal salts, FeCl2.6H20, MnCl2.4H20, and La(CF3SO3)3.xH20 were reacted with p‐ phenylenebis(picolinaldimine) (pbp) at room temperature using crystal engineering techniques. Single crystal X‐ray analysis reveals that [FeCl2(pbp)].2CH3OH is a 1‐dimensional coordination polymer. Little interaction between the parallel zigzag chains is observed, the separation distance is 8.2Å. As a result, a relatively open framework is adopted with cavity sizes suitable for small guest molecule (e.g. methanol) incorporation. Intermolecular interactions with the methanol stabilize the open supramolecular framework.

Figure 1. Crystal structure of [FeCl2(pbp)].2CH3OH. 87


TECHNICAL ABSTRACTS

Monday, p.m.

Technical Session 2 4:00 – 6:00 p.m. Portland Bio‐Environmental Chemistry Session Chair Murphy Keller, Ph.D. US Department of Energy Presenters “Pharmacological Properties Of Plants Traditionally Used As Anti‐Infe 4:00 p.m. – And For Wound Healing” 4:20 p.m. Hamilton, Allison*, Moshi, Mainen, M.D., Innocent, Ester Ph.D., Masimba, Pax, PhD, Lyn Maria, Meachem, Katrina Minority Health International Research Training; Department of Chemistry, Hampton Univ Hampton, VA 23668, Summer 2008 Abstract The root of Pterocarpus tinctorius and the leaf of Whitfieldia Elongate T.anders were collected Traditional Healers located in the western region of Tanzania . Dried and extracted with so dichloromethane, ethyl acetate, and ethanol to yield 6 extracts[1]. The extracts were test their antimicrobial activity against eight bacteria (Bacillus Cereus, Proteus mirabilis , Staphylo aureus, Salmonella typhi, Shigella flexineri, Escherichia coli, Pseudomonas Aeruginosa, and Cholerae) and two fungi(Candida Albicans and Cryptococcus Neoformans) using agar dif method[2]. The extracts were also tested for their toxicity on Artermia nauplii brine sh Minimal Inhibition Concentration (MIC) was performed on the extracts which exh antimicrobial activity. The dichloromethane and ethyl acetate extracts of Whitfieldia El T.anders and Pterocarpus inctorius showed promising antimicrobial activity. The remaining extracts exhibited minimal antimicrobial activity. All extracts exhibited minimal toxic Further analysis and research is encouraged for both plants. References: [1] P.M. Kilima, I, Ostermayer, M. Shija, M.M. Wolff, and P.J. Evans. DUHP, Swiss Tr Institute, Basel. 1993, p19 [2] Moshi, Mainen, Mbwambo, Zakaria, Ramadhani, S. O. Nondo, Masimba, Pax, Kamuh Appolinary, Kapingu, Modest, Thomas, Pascal, Richard, Marco. “Evaluation of Ethnom Claims and Brine Shrimp Toxicity of Some Plant Used in Tanzania as Traditional Hea African Journal of Traditional, 2006, 3, 48‐58. [3] Singh B, Sahu PM, Sharma MK: Anti‐inflammatory and antimicrobial activity of triterpe from Strobilanthes callosus Nees. Phytomedicine. 2002, 9 (4): 355‐359. 88


TECHNICAL ABSTRACTS “Milby Park Community: Potential Exposure To Elevated Levels Of 1,3‐ Butadiene May Cause Higher Risks For Developing Adverse Biological Effects” Natalie Roberts1, Dr. Renard Thomas*1, Dr. Bobby Wilson1, Dr. John Sapp1, Dr. Andrew James1,

4:20 p.m. – 4:40 p.m.

1Texas Southern University, College of Science and Technology, Department of Chemistry, Doctor of Philosophy Program in Environmental Toxicology, Houston, TX, 77004 Abstract Of the top 50 most produced chemicals in the United States, 1,3 – Butadiene is the 36th ranked largest commodity chemical that is produced in the United States (Butadiene, 2008). Statistics show that The United States produces about three billion pounds of butadiene every year, where approximately 12 billion pounds of this chemical is produced globally (Butadiene, 2008). However in Houston alone, in 2004, the largest amount of 1,3 – Butadiene produced in the U.S. was released right in the Milby Park Community of Houston, Texas with a concentration of 4 ppb (Clements et. al., 2006). Previous studies suggest that many drugs and environmental agents of this concentration can cause DNA damage (Shuga, 2007). The purpose of this research study is to better understand what biological adverse effects 1,3 – Butadiene may have on potentially exposed residents living in the Milby Park community of Houston, Texas between the years 2001‐2006. In this study, an in vitro rat epithelial lung cell culture system. Using a controlled environment, I plan to expose an epithelial cell line to similar doses experienced by individuals living in the Milby Park Community between the years 2001‐ 2006 over a 24 hour period. After 24 hours of exposure, each sample will be carefully analyzed for cell viability and any signs of early apoptosis or cell cycle interruption to determine if there are any occurrences of DNA damage. The adverse effects of this chemical on the rat lung epithelial cell culture will be analyzed by conducting the two assays, Guava ViaCount® assay and Guava TUNEL assay, using the Guava® EasyCyteTM Plus System. In conclusion, the data collected after analysis will allow researchers to determine whether or not potential exposure to elevated levels of 1,3 butadiene may have put the Milby Park community at higher risk for developing adverse affects relating to early apoptosis, cell viability, interruption of cell cycle progression and DNA damage. This research will help improve the air quality in the Milby Park Community, as well as help develop strategies to avoid over exposure to 1,3 – Butadiene that could possibly cause irreversible health effects. 89


TECHNICAL ABSTRACTS 4:40 p.m. – 5:00 p.m.

“Transformation Of Fluorotelomer‐Based Surfactants In Pure Fungal Cultures And Aerobic Soils” Laurel A. Royer* and Linda S. Lee Department of Agronomy, Crop, Soil and Environmental Sciences, Purdue University, West Lafayette, IN 47907 Abstract

Poly and perfluorinated alkyl compounds (PFCs) represent a unique class of currently irreplaceable synthetic chemicals that have distinctive properties including being oleophobic as well as hydrophobic, stable under strongly acidic, alkaline and oxidizing conditions, and exceptionally heat stable. These favorable product characteristics present reasons for environmental concern including prolonged persistence and a high bioaccumulative potential. Our present work focuses on the biotransformation of one sub‐class of PFCs referred to as fluorotelomer‐based surfactants. These chemicals upon release into the environment have been suspected to be potential sources of fluorotelomer alcohols (FTOH) and subsequently perfluorinated carboxylic acids (PFCAs) that pose probable mammalian health threats. We hypothesize that (1) the common ester linkages present in these molecules are susceptible to microbial attack resulting in the release of the corresponding FTOH; and (2) FTOHs produced, will follow a known degradation pathway leading to PFCA terminal products. The microbial degradation of a 1H,1H,2H,2H‐perfluorodecyl acrylate (PFA) monomer and 8:2 fluorotelomer stearate (FTS) were monitored over time in month long incubation studies with moist silty clay loam soil and pure fungal mycelia microcosms, respectively. LC/MS/MS was used to analyze and identify the degradation products. PFA degraded to fluorotelomer alcohols (FTOHs) and some PFCAs as well as fluorotelomer carboxylic acids (FTCAs). Maximum levels of 8:2 FTOH were observed by day, 4 followed by decreasing concentrations due to secondary metabolism. PFCAs of varying fluorinated chain lengths (C‐5 to C‐8) however, increased over the first 18‐days of incubation before appearing to plateau for the duration of the experiment. The estimated half‐life for the parent PFA was determined to be ~ 3 days. The Trametes versicolor fungi species showed some potential to release FTOH from FTS but showed no ability to further transform the FTOH product to PFCAs. Degradation studies to compare and contrast transformation rates of PFA in different soils types and to further probe the role of T. versicolor to hydrolyze FTS are currently being explored. 5:00 p.m. – 5:20 p.m.

“An Investigation Of Arsenic Compounds In Marine Samples” Filomena Califano*1, Dr. Kathleen Nolan2 1Dept. of Chemistry & Physics, St. Francis College, Brooklyn, NY, 11201

2 Dept. of Bilogy and Health Promotion, St. Francis College, Brooklyn, NY, 11201 Abstract A procedure is outlined for the extraction of water‐soluble arsenic in freeze‐dried marine animal 90


TECHNICAL ABSTRACTS tissues. Quantitative extraction of arsenic in the water‐soluble fraction of scallops, shrimp, and Silver Side (also known as Atheriniform) is consistent with that reported in the literature for these marine samples. Our results indicate that when samples are prepared in a similar manner, the efficiency to extract arsenic will depend on the marine animal species and tissue analyzed. The robustness of this extraction procedure to identify and quantify arsenic species in freeze‐ dried marine animal tissues was determined using high performance liquid chromatography and the certified reference materials. Arsenic species determined in our samples were AsB and DMA. “Formation Of PCDD/Fs From The Copper Oxide Surface‐Mediated Reactions 5:20 p.m. – Of 1,2‐Dichlorobenzene Under Pyrolytic Conditions” 5:40 p.m. Shadrack Nganai, Slawomir Lomnicki, Barry Dellinger Louisiana State University,Chemistry Department, Baton Rouge Abstract It has been clearly demonstrated by multiple researchers that polychlorinated dibenzo‐p‐dioxins (PCDDs) are formed by the surface‐mediated reactions of chlorinated phenols. In this study, we investigated the potential contribution of chlorinated benzenes. 50 ppm of 1,2‐dichlorobenzene in a nitrogen carrier gas was reacted over a packed bed of 5 % CuO/silica. Reaction products included chlorobenzene, trichlorobenzenes, tetrachlorobenzenes, pentachlorobenzenes, phenol, 2‐monochlorophenol, and dichlorophenols with yields ranging form 0.01 to 1% for the phenols and 0.01 to 10 % for chlorinated benzenes. 4,6‐dichlorodibenzofuran (4,6‐DCDF) and dibenzofuran (DF) were observed in maximum yields of 0.2 % and 0.5 %, respectively, from 300‐ 500 C. In previous studies of 2‐MCP under identical reaction conditions, 4,6‐DCDF and dibenzo‐ p‐dioxin were observed with maximum yield of ~0.15 % along with trace quantities of 1‐ monochlorodibenzo‐p‐dioxin (1‐MCDD). When combined with the fact that measured concentrations of chlorinated benzenes are 10‐100x that of chlorinated phenols in combustion systems, the data suggests that surface‐mediated reactions of chlorinated benzene are possibly the predominant precursor of PCDD/Fs. In contrast to data for chlorophenols, the low PCDD to PCDF ratio of 0.07 observed in these experiments is in general agreement with the results of full‐ scale measurements. A mechanism in which chlorinated benzenes react on the copper oxide surface to form chemisorbed chlorophenolates and chlorophenoxyl radicals is proposed based on agreement with product distributions and previous studies of persistent free radical (PFR) formation on copper oxide surfaces. “Induced Fluorescence Enhancement: A Method For Identifying Bacterial 5:40 p.m. – 6:00 Species” p.m. Marlon Thomas, Elizabeth Zielins and Valentine I. Vullev* Department of Bioengineering, University of California, Riverside, CA 92521 Abstract The virulence and increasing antibiotic resistance of certain bacterial strains creates a need for 91


TECHNICAL ABSTRACTS efficient and timely detection of environmental pathogens. We evaluated the kinetics of the fluorescence enhancement of cationic dyes as an assay for differentiation between bacterial specie. For several benzothiazole cationic dyes, such as 3‐3’‐diethylthiacyanine, we observed fluorescence enhancement in the presence of vegetative bacteria and bacterial spores. Different bacterial species manifested different rates of emission enhancement. Although staining has been a broadly used technique for the identification of bacterial species, the kinetics of the staining process has not previously been examined. We hypothesized that the kinetic parameters can be utilized as “fingerprints” for detection and identification of bacterial species. We used three different vegetative bacteria and three different bacterial spores as model organisms to test our hypothesis. Kinetic emission assays with various concentrations of bacteria and fluorophores allowed us to determine the diffusion constants of the fluorescence enhancement of the dye diffusing into the bacteria cell wall. These diffusion constants reflect the velocity of the migration of the dye from the surrounding media to the fluorogenic microenvironment within the bacterial cell wall. Development of this assay breaks a century old tradition of identifying bacteria using differential staining techniques. In addition it allows us to move us away from obtaining strictly Boolean outcomes.

Tuesday, a.m.

Technical Session 3 9:45 – 11:45 a.m. Portland/Benton Biotechnology and Biochemistry Applications I Session Chair Alexis Campbell Department of Biochemistry, Biophysics and Molecular Biol Iowa State University Presenters 9:45 a.m. – “Highlighted Speaker” “Biophysical, Biochemical, And Bioanalytical Approaches To Char 10:20 a.m. Diverse Molecular Details Of Ras‐Related Proteins” Paul D. Adams* Department of Chemistry and Biochemistry, University of Arkansas, Fayetteville, AR 72701 Abstract Structure‐function relationships among proteins underlie the chemical and molecular b many biological processes. The Ras super family of proteins are important in regulat growth, and have served as model prototypes for understanding protein structure‐f relationships vital for normal biological activity in cells. In addition, Ras (Ras sarcoma) p were among the ‘first’ human oncogenic proteins to be identified. Abnormal expression o proteins, leading to altered effector/regulator interactions, has been found in up to 30% of cell types, and they have also been shown to be involved in stresses such as diabetic nephr 92


TECHNICAL ABSTRACTS These Ras proteins are controlled via cycling between active Guanosine Triphosphate (GTP)‐ and inactive Guanosine Diphosphate (GDP)‐bound states. The cycle of binding, hydrolysis and rebinding of the nucleotide are controlled by interactions with regulatory proteins. Therefore, this class of GTP‐binding signaling proteins has provided excellent models to probe the structure‐ function relationships of cell‐signaling processes. Our research focuses on the use of biophysical, biochemical, and bioanalytical techniques to examine molecular features of constructs of Ras‐ related proteins in order to interpret the roles these proteins’ have in cell signalling activities. The Ras proteins presently being studied in the laboratory include Cdc42Hs (Cell division cycle 42 Homo Sapiens) and Rheb (Ras homology enriched in brain), both of which are involved in a wide range of cellular processes including cell cycle progression, cytoskeletal organization, protein trafficking, and secretion. Studies of Cdc42Hs have shown mechanisms that can facilitate abnormal activity by the protein including: 1) mutations that alter the internal GTP hydrolysis activity of the protein leading to an “over‐active” state, and 2) altered interactions with important proteins that regulate normal function of the protein. Functional studies of Rheb, however, suggest that it behaves different from other Ras proteins, i.e., mutations that convert Ras proteins (e.g. Cdc42Hs) into over‐ active proteins, do not have the same effect in Rheb. In addition, some biological functions of Rheb have been recently determined, and an important interaction between Rheb and the tumor suppressor complex proteins (TSC1 and 2) stimulates cell growth by mediating the mammalian Target Of Rapamycin (mTOR) pathway, which regulates cell growth, energy and nutrient levels. However, molecular details of this important Ras protein‐effector protein interaction are unknown. We wish to understand molecular details of mechanisms that underlie specific functions of these proteins that can be translated into meaningful insights into the structure‐function relationship of these proteins in the cell. Another objective of our research is the development of new bioanalytical methods to facilitate large‐scale production and purification of pure recombinant proteins, as this is the first, and perhaps, the most important step towards elucidation of in‐vitro structure‐function relationships. Presently, we are developing new strategies to prevent degradation of recombinant proteins caused by non‐specific cleavage by specific proteases. We have demonstrated that degradation due to non‐specific cleavage of recombinant protein mediated by the protease thrombin can be completely prevented by exploiting thrombin’s affinity for heparin to separate it from the recombinant protein during purification. This method is generally applicable to all recombinant proteins that require thrombin for the cleavage of affinity tags for purification. 10:20 a.m. – 10:40 a.m.

“Monolayers With Self‐Limiting Packing Densities For The Inhibition Of Nonspecific Protein Adsorption”

Marlon L. Walker1*and David J.Vanderah2 1Surface and Microanalysis Science Division, 2Biochemical Sciences Division Chemical Science and Technology Laboratory, National Institute of Standards and Technology, Gaithersburg, MD 20899 Abstract We have created a molecule, utilizing the ethylene oxide (EO) motif, that forms self‐assembled monolayers (SAMs) on Au and possesses the capability for inhibition of nonspecific protein 93


TECHNICAL ABSTRACTS adsorption

The

bipodal

molecule

CH3O(CH2CH2O)5CH2CON(CH2CH2CH2SCOCH3)2

[nomenclature: N,N‐(bis 3’‐thioacetylpropyl)‐3,6,9,12,15,18‐hexaoxanonadecanamide, BTHA] adsorbs onto polycrystalline Au, forming layers similar in optical thickness to monothio (EO)5‐ 6CH3 SAMs at the projected optimal coverage for non‐specific protein adsorption resistance. Spectroscopic ellipsometry (SE) measurements confirm excellent resistance of these monolayer films to the adsorption of proteins such as fibrinogen, bovine serum albumin, and mixtures of the two, suggesting uniform EO surface coverage on a length scale at least comparable to the smallest dimension of these proteins. “Determination Of Absolute Configurations Of 1,N‐Chiral Diols Using 10:40 a.m. – The Fluorinated Porphyrin Tweezer Via Exciton Coupled Circular 11:00 a.m. Dichroism (ECCD)” Sumira Y. Stein, Xiaoyong Li, Babak Borhan* Michigan State University, Department of Chemistry, East Lansing MI 48824 Abstract Chiral 1,n‐diols are widely present in biological active molecules. The biological activity of chiral 1,n‐diols is affected by the absolute configurations of the substrate. Therefore, methods that determine absolute stereochemistry are significant. Nuclear Magnetic Resonance (NMR) and X‐ray crystallography are among methods that exist to determine stereochemistry. However, to use NMR, chemical derivatizations are required, and is applicable for chiral alcohols and amines. X‐ray crystallography also has setbacks because most componds are hard to cystallize and the crystallized compound must contain a heavy atom (Br, I) for stereochemical determination. Exciton Coupled Circular Dichroism (ECCD) is a non‐empirical method for absolute stereochemical determination of chiral compounds. It is based on the throuugh space interaction of the electric dipole transition moment of two or more non‐conjugated chromophores. This interaction leads to the observed bisignate CD spectrum. The fluorinated porphyrin tweezer 1 has been used as a tool to determine absolute stereochemistry of erythro and threo diols, amino alcohols and diamines in a nonempirical fashion. Reported is a method to determine the absolute configuration of chiral 1,n‐ diols. The fluorinated porphyrin tweezer binds strongly to hydroxy groups due to its high Lewis acidity. The host‐guest complex formed between the chiral 1,n‐diols (containing 6‐12 carbons) and fluorinated porphyrin tweezer exhibit an electron‐coupled CD spectrum. This bisignate curve is based on the through space interaction of electric dipole transition moment of the porphyrin chromophores, which adopt a unique helicity due to steric differentiation of substituents of the chiral center. Consequently, the stereochemistry of chiral diols is reflected by the observed ECCD signal.

94


TECHNICAL ABSTRACTS F

F

F

F

F

F

F N

F

N Zn

F F

F

N

F N

F F

F F

F

F

F

F

F

F N

F O

N

F

F

Zn N

F N

F

F

O

TPFP Tweezer 1

11:00 a.m. – 11:20 a.m.

F

F

O

O

“The Molecular Characterization Of Maize Fatty Acid Elongase”

Alexis A Campbell*, and Basil J Nikolau Iowa State University, Department of Biochemistry, Biophysics and Molecular Biology Ames, IA, Abstract Very long chain fatty acids (VLCFAs) are fatty acids comprised of greater than 18 carbon atoms in chain length. VLCFAs play an important role in protein trafficking, membrane stabilization, and are precursors for lipid second messengers. In plants, VLCFAs are components of several classes of molecules including cuticular waxes, suberin, sphingolipids, phospholipids, seed oils, and glycophosphatidylinositol (GPI) anchors. Such fatty acids are synthesized by two enzyme systems, fatty acid synthase (FAS, synthesizes fatty acids up to 16 or 18 carbon units in chain length) and fatty acid elongase (elongase, elongates preexisting fatty acid primers stemming from FAS to produce VLCFAs). These two systems are thought to be analogous to each other with regard to the biochemical reaction series each catalyze. Both systems carry out a cyclic reiterative series of reactions catalyzed by four enzymatic reactions: 3‐ketoacyl synthesis, 3‐ketoacyl reduction, 3‐hydroxyacyl dehydration, and an enoyl reduction. Much is known about FAS, however, the nature of elongase has proven difficult to characterize via traditional biochemical approaches. Our interest in elongase stemmed from the identification of the first Ketoacyl‐CoA Reductase (KCR), glossy8 and its paralog glossy8b of maize. Over the past decade each of the four genes encoding elongase components have been elucidated. The identification of archetypal proteins encoding the three other components has allowed for in silico identification of maize homologs (24 KCS, 1HCD & 1ECR). To understand this complex system we have elected to use both in vivo and in vitro expression systems. The goal of building these expression systems is to gain a greater understanding of how VLCFAs are synthesized. With this knowledge comes the ability to specifically bioengineer VLCFA metabolism and their derivatives, which further provides a need for understanding the enzymatic components of the elongase system and how these enzymes work in cooperation and coordination 95


TECHNICAL ABSTRACTS with each other. In addition, this research provides a deeper appreciation for how lipid compositions and asymmetries are created and maintained within a cell that allow lipids to perform a variety of different functions. 11:20 a.m. – “Functional Analysis Of Maxi‐K Potassium Channels In Tethered Bilayer Lipid Membranes On A Gold Substrate” 11:40 a.m. George O. Okeyo*1, Daniel Fine2, Ananth Dodabalapur2, Rebecca B. Price3, Peter A. V. Anderson3 and Randolph S. Duran1 1University of Florida, Department of Chemistry, Gainesville, FL 32611, 2University of Texas at Austin, Microelectronics Research Center, Austin, TX 78712, 3University of Florida, Whitney Laboratory for Marine Bioscience, St. Augustine, FL 32080 Abstract In recent years, ion channels have generated enormous interest for their viability as drug targets and their potential for use in applications such as development of biosensors for analyte detection. High conductance calcium‐activated (maxi‐K) potassium channels are an excellent choice to study because of their ubiquity in cells. Additionally, their inherently high conductance, ease of genetic manipulation and expression in Xenopus laevis oocyte membranes, as well as their well‐known pharmacological profile make them ideal for biosensor development. Several membrane systems under varied experimental configurations have been considered for functional studies of ion channels, however most of these tend to be electrically unstable and/or labile to mechanical shock. We have successfully incorporated maxi‐K channels in a tethered membrane on a gold microelectrode array device and have been able to demonstrate functional reconstitution, with significantly greater stability. The measured ionic currents associated with gating events are in the picoampere range, showing sensitivity necessary for stochastic sensing of analytes. Within this setup, we can probe the pharmacological response of the channel using quaternary ammonium compounds known to influence gating properties and peptidyl toxins such as charybdotoxin (ChTX) known to potently inhibit the maxi‐K channel. There is channel blockade on exposure to derivatives of tetraethylammonium at micromolar concentrations manifested by inhibition of the flow of ionic currents. This reflects the potential of this experimental configuration for use in applications such as biosensor development and for the fundamental study of pore‐forming proteins.

96


TECHNICAL ABSTRACTS Tuesday, a.m.

Technical Session 4 9:45 a.m. – 11:45 a.m. Parkview Physical Chemistry Session Chair Darlene Taylor, Ph.D. Department of Chemistry, North Carolina Central University Presenters “High Spectral Resolution Infrared Study Of Hydrocarbons In The Jovian 9:45 a.m. – Atmosphere” 10:05 a.m. Ramsey L. Smith*1,2, Theodor Kostiuk1, Timothy A. Livengood1,3, Kelly E. Fast1, Tilak. Hewagama1,3, Juan D. Delgado1,3, and William Blass4 1NASA Goddard Space Flight Center, Code 693, Greenbelt, MD 20771 2Oak Ridge Associated Universities/ NASA Postdoctoral Program, Oak Ridge, TN 37831 3Department of Astronomy, University of Maryland, College Park, MD 20742 4Department of Physics, University of Tennessee, Knoxville, TN 37996 Abstract Infrared heterodyne spectroscopy, IRHS, is a high‐resolution spectroscopic technique used to measure the spectra of molecular atmospheric constituents in both laboratory spectroscopy and remote sensing, with a resolution of 107. During our observational campaign in June 2008, we collected infrared heterodyne spectra of the Jovian atmosphere using the Goddard Heterodyne Instrument for Planetary Wind and Composition, HIPWAC, which was interfaced with the 3‐ meter telescope at the NASA Infrared Telescope Facility. Auroral and stratospheric emission features of hydrocarbons, such as ethane (C2H6), have been identified in the spectra we collected from Jupiter’s atmosphere. The GSFC Laboratory Infrared Heterodyne Spectrometer has the capability to resolve the shape of individual rotational‐vibrational transitions, discriminate transitions from each other, and accurately measure the strength of weak transitions in order to identify molecular species in astronomical spectroscopy and deduce atmospheric properties. 10:05 a.m. – 10:25 a.m.

“High‐Accuracy ab initio Studies of Sn (n=1‐4) Electronic Structure” John A.W. Harkless* Department of Chemistry, Howard University, 525 College St., NW, Washington, DC 20059 Abstract

Quantum Monte Carlo methods are applied to the problem of conformer energetics of Sn, n=1‐4. 97


TECHNICAL ABSTRACTS The results presented here add to the estimate of the energy gap between the C2V and D4h conformers of S4, an important species in interstellar chemistry. VMC and DMC estimates of symmetric and asymmetric dissociation of S4, electronic excited states and dissociation energies of S3 and S2, and excitations of S atom are also reported. The overall effectiveness and accuracy of the method is compared against available theory and experiment. 10:25 a.m. – “Quantum Mechanical Prediction of 1H and 13C NMR Chemical Shifts in Large 10:45 a.m. Protein Systems” Duane Williams*1, Bing Wang1 and Kenneth M. Merz, Jr.1 1University of Florida, Department of Chemistry & Quantum Theory Project, Gainesville, FL Abstract We have implemented a methodology for qualitative description Nuclear Magnetic Resonance (NMR) chemical shift tensors at the semiempirical AM1 level and have generated the associated 1H and 13C NMR‐specific AM1 parameters. Using our linear‐scaling divide‐and‐conquer algorithm to perform the quantum mechanical calculations, we carried out this parameterization using a series of globular protein systems with a variety of secondary structure as the training set. Our approach can be employed using semiempirical (AM1/PM3) geometries and can be executed at a fraction of the cost of ab initio methods, thus providing an attractive option for the quantum mechanical studies of NMR on large protein systems. 10:45 a.m. – 11:05 a.m.

“Gold Nanoparticle Based NSET Assay For Monitoring RNA Folding Kinetics”

Jelani K. Griffin*, Uma S. Rai and Paresh C. Ray Department of Chemistry, Jackson State University, Jackson, MS, 39217 Abstract RNAs play critical functional roles in metabolism, replication, regulation, and development of cells. How RNA molecules fold into functional structures is a problem of great significance given the expanding list of essential cellular RNA enzymes and the increasing number of applications of RNA in biotechnology and medicine. RNA is the key enzymatic component in a number of essential cellular processes, such as translation and splicing. Steady‐state FRET measurements in solution allow one to measure the kinetics and requirements of docking of its two independently folding domains; time‐resolved FRET reveals the relative thermodynamic stability of the undocked (extended, inactive) and docked (active) ribozyme conformations. However, the length scale for 98


TECHNICAL ABSTRACTS detection using FRET‐based methods is limited by the nature of the dipole‐dipole mechanism, which effectively constrains the length scales to distances on the order of <100 Å (R0≈60 Å).Here we want to demonstrate that gold nanoparticle based NSET can be used to track the folding of RNA. As a model system, the conformational changes two‐helix junction RNA molecules induced Mg2+ ions is studied by measuring time dependent fluorescence signal. The transition from an open to a folded configuration changed the distance between gold nanoparticles and the dye molecule attached to the ends of two helices in the RNA junction. So the folding process has been monitored from the change of fluorescence intensity. “Reactive Coatings: Neutralizing‐Decontaminating Coating For Chemical 11:05 a.m. – Warfare Agents” 11:25 a.m. Dave A Jenkins* and H. Neil Gray The University of Texas at Tyler, Department of Chemistry, Tyler, TX, 75799 Abstract A reactive coating was developed to facilitate cleanup after a terrorist attack involving chemical and/or biological warfare agents (CBWAs). Though only in initial development, the goal is a coating that will both sequester and neutralize CBWAs. Our prior work involved the development of coatings for the chemical warfare agents plutonium and uranium. Our current research deals with coating for phosphorus based nerve agents. We desired coatings with high elasticity, durability, wet tack, reactivity, and longevity. Poly(ethylene oxide), PEO, was used as the foundation of the coating. Poly(vinyl pyrrolidone) was added to increase strength, durability, and wet tack. Glycerin was added as a plasticizer in water. The destruction of the biological or chemical warfare agent would be accomplished using an SN2 reaction. Since SN2 is a fast one step mechanism that has been reported in the chemical destruction of organophosphorus warfare agents, we investigated it ability to do so in our decontaminating coatings. The initial results are very promising. The SN2 reactions have successfully reacted with the substrates benzylbromide, pentylbromide, and cyclohexylbromide. The next step is working with mimic agents, agents which mimic the structure but not toxicity of the CBWAs. We also plan to work toward the creation of sensors that will detect CBWAs 11:25 a.m. – “The Temporal Changes In The Emission Spectrum Of Comet 9P/ Tempel 1 After Deep Impact” 11:45 a.m. William M. Jackson*1, XueLiang Yang1, Xiaoyu Shi1 and Anita L. Cochran2 1Department of Chemistry, University of California, Davis 2McDonald Observatory, University of Texas at Austin Abstract The time dependence of the changes in the emission spectra of Comet 9P/Tempel 1 after Deep Impact are derived and discussed. This was a unique event because for the first time it gave 99


TECHNICAL ABSTRACTS astronomers the opportunity to follow the time history of the formation and decay of O(1S), OH, CN, C2, C3, NH, and NH2. Least squares fits of a modified Haser model with constraints using known rate constants were fit to the observed data. In the case of OH a simple two‐step Haser model provides a reasonable fit to the observations. Fitting the emissions O(1S), CN, C2, C3, NH, and NH2 requires the addition of a delayed component to a regular two or three step Haser model. From this information a picture of the Deep Impact encounter emerges where there is an initial formation of gas and dust, which is responsible for the prompt emission that occurs right after impact. A secondary source of gas starts later after impact when the initial dust has dissipated enough so that solar radiation can reach the surface of freshly exposed material. The implications of this and other results are discussed in terms of the implications on the structure and composition of the comet’s nucleus.

Tuesday, a.m.

Technical Session 5 9:45 – 11:45 a.m. Aubert Dr. Henry McBay Outstanding Teacher Award Symposium – STEM Education Session Chair Michael Page, Ph.D. Department of Chemistry California State Polytechnic University Pomona Presenters 9:45 a.m. – 10:05 Dr. Henry McBay Outstanding Teacher Awardee “Enhancing The Design Of Classical Physical Chemistry Laboratory a.m. Experiment In Order To Appeal To Students: Determining The Heat O Vaporization (∆Hvap) Of A Pure Liquid” Shawn M. Abernathy, Ph.D.* and Anwar D. Jackson Howard University, Department of Chemistry, Washington, DC 20059 Abstract Physical chemistry is typically deemed by undergraduate chemistry majors as the most d field of chemistry to grasp. One of the most vocalized reasons is that “To much calculus and is required to understanding understand the chemical concepts.” Many students struggle to coal quantum mechanics and thermodynamics taught in the lecture course, i.e. in textbooks, w real world around them. The challenge confronting the physical chemistry professo formulate a pedagogical approach that makes the most important laws and theoretical c understandable to undergraduate students. One approach is to upgrade and enhance som traditional experiments in the physical chemistry laboratory course with more sophi equipment as well as digital and portable devices in order to stay in step with modern p chemistry. A well‐known phase equilibrium experiment in the physical chemistry lab 100


TECHNICAL ABSTRACTS “Vapor pressure of a pure liquid” has been upgraded and the design enhanced. The upgraded experimental apparatus was used to determine the heat of vaporization (∆Hvap) of water and toluene. The empirical results and the effectiveness of this improved experimental design on the class impression of physical chemistry will be discussed. The integration of digital and portable devices into classical physical chemistry experiments is a must in order to heighten student interest and appeal. It is also imperative for the development of our student’s research aptitude, and the next generation of research chemist. 10:05 a.m. – 10:25 “Affecting Science Motivation Of High School Students Through Enrichment Programs And Peer Instruction” a.m. George D. Howell, Edward Walton, Laurie Riggs, and Michael F. Z. Page* Email: mfpage@csupomona.edu Chemistry Department, California State Polytechnic University Pomona 3801 W. Temple Ave. Pomona, CA 91768 Abstract At Cal Poly Pomona, we have developed an innovative teacher/student program that couples high school science teachers with trained student laboratory teaching assistants; thereby increasing the teaching capacity of the instructor, and allowing the class to perform more hands‐on activities and laboratory experiments. We feel that this innovative approach of involving both the teacher and students (as peer instructors) in the educational design of science lessons is critical if the United States is to meet the bold goal of science literacy for all students. (Research Council 1996) This/Our innovative summer‐enrichment program has been successfully piloted for the past two years. Over this time, 34 teachers from Southern California (representing 15 schools and 11 school districts) have participated in two‐week teacher workshops along with concurrent one‐week summer‐ enrichment programs for 42 high school students. Student participants completed evaluations before and after our summer programs and after serving as a teaching assistant in their local classroom for one academic quarter. This data allowed us to analyze and identify changes in the participants’ personal feelings of a. motivation, b. confidence, c. social encouragement, d. self‐ esteem, and e. attitudes towards pursuing a career in the STEM disciplines. The results of these studies and affects on the quality of classroom instruction will be discussed during this presentation. 101


TECHNICAL ABSTRACTS 10:25 a.m. – 10:45 “Establishing Effective Summer Camp Programs In Nanoscale Science For High School Students” a.m. Sherine O. Obare* Department of Chemistry and the Nanoscale Science Program University of North Carolina at Charlotte Charlotte, NC 28223 Abstract The twenty‐first century requires the training of scientists and engineers in interdisciplinary fields to enable them to address evolving challenges in science and technology. The ability to train future scientists at an early age provides significant promise toward increasing the number of trained students that can tackle various scientific and technological problems. An excellent way to educate students and get them excited about chemistry and materials science is organizing effective summer camps on university campuses. By careful selection of exciting experiments that are life‐ related, students are able to relate scientific concepts to everyday matters. We have developed a number of significant projects for high school students to help them understand how chemistry and materials science can lead to significant advances in alternative energy, environmental science and biology. The projects provide an opportunity for young students to have hands‐on learning experiences with instruments used in research laboratories while increasing their skills and understanding of modern scientific technology. These projects not only stimulate studentsʹ interest in chemistry, but further demonstrate the relevance of chemistry in everyday life. 10:45 a.m. – 11:05 “Transitioning to College: Using Research to Bridge the Culture Gap” a.m. Dr. Alvin P. Kennedy* Morgan State University, Department of Chemistry, Baltimore, MD 21133 Abstract Freshman can have a difficulties adjusting to the university environment because of the cultural differences between high school and the university. The transition to college places a different set of demands on a student in terms of time management, study habits, and basic critical and analytical thinking skills that are needed to be successful at a university. Some of the issues that affect a freshmen successfully transitioning into the university culture can be addressed through early research experiences. Morgan has developed a Continuous Undergraduate Research Experience (C.U.R.E.) in an effort to address these issues. The potential impact of early research experiences on student success and retention will be presented. 102


TECHNICAL ABSTRACTS 11:05 a.m. – 11:25 a.m.

“Innovations In Science Outreach: The Importance Of Legitimate Scientific Discovery”

Kenya T. Powell*1,2, Carolyn J. Anderson2, and Vicki L. May1 1Science Outreach Office and the 2Departments of Chemistry and Radiology Washington University in Saint Louis, Saint Louis, MO 63130 *Corresponding author: ktpowell@artsci.wustl.edu Abstract As a result of the scientific community’s efforts to diversify the science landscape, there have been marked shifts over the past two decades in all aspects of science education, including pedagogy, culture, methodology, and assessment. Owing to these endeavors has been a rise in the level and promotion of science outreach programs. Once thought to encompass only isolated demonstrations of an abstract science concept, science outreach has grown such that short‐lived demonstrations have become long‐lived “programs”, with multi‐million dollar annual funding from organizations like the National Science Foundation and the National Institutes of Health, among others. These investments have propelled the recent renaissance in science education and continue to undergird its growth and influence its direction. The Washington University‐centered Program of Excellence in Nanotechnology Skills Development Component has investigated the effect of science outreach innovations, activities, and programs on the short and long‐term engagement of emerging scientists at all levels. Furthermore, we have a keen interest in practices that best promote excitement and curiosity in science students. In order to examine educational phenomena, collaborations between researchers and community educators are vital. Moreover, new models must be constructed that allow us to better understand and classify what is being observed and what components or combinations thereof constitute a successful program. Thus, our outreach events are designed to (1) be modular, i.e. capable of targeting several age groups; (2) employ actual chemical research and include interactions with science researchers; (3) be hands‐on; and (4) enhance the curricula of teacher partners. They are also designed to employ the tools of informal inquiry, including surveys, interviews, and observations. Herein we report the design, implementation, and characterization of three polymer chemistry‐centered, nanotechnology‐based outreach activities performed with different age groups, and the development of an “emotionality” matrix as an observation and evaluation model. 103


TECHNICAL ABSTRACTS 11:25 a.m. – 11:45 “Show Me The Money: Funding Opportunities For Chemical Scientists (Students, Post‐Docs, Academicians, And Other Chemical Professionals) At a.m. The National Science Foundation” Chavon Renee Wilkerson* National Science Foundation Division of Chemistry 4201 Wilson Boulevard, Arlington VA, 22311 Abstract Both the House of Representatives and the Senate have agreed to a substantial increase (13%) in the budget to NSF because they believe that ʺcontinued excellence in fundamental research and education is important to sustain innovation and sharpen the Nationʹs competitive edge.ʺ Learn what opportunities are available for Federal funding to support your plans and ideas in science research, education, and outreach activities. This presentation will highlight some of the many funding opportunities available from the National Science Foundation (NSF) that are focused on or place a key emphasis on Broadening Participation activities (e.g. Louis Stokes Alliance for Minority Participation‐LSAMP, American Competitiveness in Chemistry Fellowships‐ACCF, Historically Black Colleges and Universities Undergraduate Program‐HBCU‐UP, Robert Noyce Scholarship Program for teachers, etc.). The talk will also discuss new NSF funding mechanisms that seek to support high‐risk, exploratory and potentially transformative research.

Tuesday, p.m.

Technical Session 6 Portland/Benton 1:45 – 3:30 p.m. Biotechnology and Biochemistry Applications II Session Chair Mo Hunsen, Ph.D. Department of Chemistry, Kenyon College Presenters “Green Chemistry Via Catalytic Reactions” 1:45 p.m. – 2:10 p.m. Mo Hunsen* Department of Chemistry, Kenyon College, Gambier, OH 43022 Abstract Green chemistry has come to the forefront of science research in the last two decades. W been active in pursuing green chemistry by way of catalytic reactions. Our lab investigat green oxidation reactions and enzyme catalyzed organic reactions. Chromium reagents ha 104


TECHNICAL ABSTRACTS proven to be powerful oxidizing reagents and are important in organic transformations. Notable chromium reagents include the Jones Oxidation reaction where chromic acid is used and the Corey reagent where the milder pyridinium chlorochromate is used. The chromium waste generated in these reactions makes these reactions less advantageous, especially for large scale and industrial applications, due to the carcinogenicity of chromium. We have developed new reactions for preparation of aldehydes, ketones, and carboxylic acids from alcohols where the chromium reagents are used as catalysts as opposed to being used as reagents. A secondary oxidant that is recyclable or that does not generate toxic waste is used to regenerate the chromium catalyst. As a secondary oxidant we have used periodic acid that is recyclable by electrolysis. We also show that oxone® as a cheap secondary oxidant is an excellent reagent to regenerate the chromium reagent. When oxone is used as the secondary oxidant, the byproduct is a simple potassium sulfate salt. Hence, using the chromium reagents as catalysts, we are able to reduce the amount of chromium waste generated by a 100 fold while maintaining the advantages of chromium oxidations . It is even more interesting to note that the ‘chromium waste’can be reused as a catalyst by using fresh secondary oxidant. This presentations focuses on green oxidations reactions but we will also briefly share some of our recent results in enzyme catalyzed organic reactions if time allows. “Hyaluronic Acid Derivatives For Cellular Encapsulation” 2:10 p.m. – 2:30 p.m. TaNeshia Washington*, Chris Highley, Sasha Bakhru, and Stefan Zappe Benedict College, Columbia, SC Abstract Cellular encapsulation has been studied as a way to immunoisolate implanted cells and, more recently, as a means of expansion and phenotype maintenance of cell lines, such as embryonic and neural stem cells. Polyelectrolytic materials are often used for encapsulation via complex coacervation. Hyaluronic acid (HA), a natural, mammalian biomaterial, has been shown to positively affect cell growth, proliferation, and differentiation. It is negatively charged, and can be modified using N‐(3‐dimethylaminopropyl)‐Nʹ‐ethylcarbodiimide (EDC) and N‐ hydroxysuccinimide (NHS) chemistry to link adipic acid dihydrazide (ADH) to the backbone, replacing the hydroxyl groups with amino groups to introduce positive charge. In this study, HA is treated with sodium periodate to cleave the ring in D‐glucuronic acid and form dialdehyde residues, which are oxidized to create additional carboxyl groups. An HA‐derivative has been developed with increased negative charge, which can be used in encapsulation or further modified using EDC/NHS chemistry to link ADH, creating positive charge. Similarly, the increased number of carboxyl groups can allow the incorporation of bioactive molecules while still maintaining an overall negative charge necessary for polyelectrolytic complexation. Varying reaction conditions allows for control over the amount of charge, and the engineering of the material for specific applications. HA may thus be used as the base material for cellular encapsulation, imparting both natural and engineered properties to the system depending on a controllable synthesis. 105


TECHNICAL ABSTRACTS “Peptide Targeting Of Platinum Anti‐Cancer Drug” 2:30 p.m. – 2:50 p.m. Margaret W. Ndinguri*, Sita S. Aggarwal, Robert P. Gambrell and Robert P.Hammer* Department of Chemistry, Louisiana State University, Baton Rouge, LA 70803 Abstract Several platinum compounds have been approved by FDA for treatment of many form of cancers. While these drugs are effective, they have very serious side effects and also certain cancer can develop resistance to drugs like cisplatin. Our overall goal is to target tumor cells using a conjugate of cisplatin and it’s analogues with the tumor homing cyclic peptide CNGRC. The key aspect to this novel peptide sequence is that it has been identified as a unique peptide that homed` specifically to solid tumors in murine breast carcinoma models. Various Peptide drug conjugate containing the same sequence have been shown to be more effective than the drug alone. For instant, recently doxorubicin (DOX)‐peptide conjugate was shown to deliver DOX to cancerous cells more effectively than free DOX. The specificity of this conjugate drug can be enhanced by efficient delivery of cisplatin and it’s analogues to the nucleus of the cancer cells. In this study we present novel peptide–platinum conjugate to investigate the biological effect of the linker, tumor cell selective localization and cell uptake. Recent results on synthesis peptide‐platinum conjugate and viability studies will be presented. “Assessing The Effectiveness Of Rhein As An Anti‐Angiogenic Agent In The 2:50 p.m. – Treatment Of Breast Cancer” 3:10 p.m. Vivian E. Fernand1, Emily E. Villar1, Robert E. Traux2, Sayo O. Fakayode3, Mark Lowry1, Jack N. Losso4, and Isiah M. Warner*1 1Department of Chemistry, Louisiana State University, Baton Rouge, LA 70803 2Biotechnology Laboratories, Louisiana State University, Baton Rouge, LA 70803 3Department of Chemistry, Winston‐Salem State University, Winston‐Salem, NC 27110 4Department of Food Science, Louisiana State University, Baton Rouge, LA 70803 Abstract Rhein (4,5‐dihydroxyanthraquinone‐2‐carboxylic acid) is the primary anthraquinone in the roots of Cassia alata Linn (Leguminoseae). This phenolic compound has been reported to inhibit cell proliferation, induce apoptosis, and reduce the glucose metabolism of neoplastic cells. The genes that encode for these processes as well as for angiogenesis are primarily mediated through the hypoxia inducible factor‐1 (HIF‐1), which is in turn stimulated by hypoxia. This transcription factor is responsible for increasing the invasion capacity, angiogenesis, and proliferation of breast cancer cells. Therefore, the focus of this study was to evaluate the effect of rhein on the inhibition of hypoxia‐induced tumor angiogenesis in hormone‐dependent (MCF‐7) and hormone‐ 106


TECHNICAL ABSTRACTS independent (MDA‐MB‐435s) breast cancer cell lines. Rhein inhibited endothelial cell tube formation, MCF‐7 and MDA‐MB‐435s cell viability, MDA‐ MB‐435s cell invasion and migration under in‐vitro normoxic and hypoxic conditions. In order to determine rhein’s mechanism of action, an in‐depth biochemical analysis of its anti‐angiogenic activity was performed. The effect of rhein on levels of vascular endothelial growth factor (VEGF) and epidermal growth factor (EGF), secreted by MCF‐7 and MDA‐MB‐435s cells under normoxic and hypoxic conditions, was determined by use of ELISA. Rhein significantly reduced VEGF and EGF levels of supernatant fractions in both cell lines. In addition, nuclear extracts of rhein‐treated MCF‐7 and MDA‐MB‐435s cell lines were analyzed using ELISA to determine the levels of HIF‐1 activity. Results indicate that rhein significantly inhibited CoCl2‐stimulated HIF‐1 activities in both cell lines. HIF‐1 inhibition was associated with decreased nuclear translocation of this factor as well as decreased VEGF and EGF levels in cell culture supernatants. These data indicate that targeting HIF‐1 with rhein as a therapeutic agent has the potential to inhibit VEGF expression, and hence, suppress MCF‐7 and MDA‐MB‐435s tumor growth. 3:10 p.m. – “Insights Into The Cellulose Hydrolysis Mechanism Of Cytophaga Hutchinsonii Based On Computer Modeling And Site‐Directed Mutagenesis 3:30 p.m. Of CEL9A” Clifford Louime*1, Michael Abazinge2 (1)College of Engineering Sciences, Technology and Agriculture, (2) Environmental Sciences Institute, FSH Science Research Center, Florida A&M University, Tallahassee, FL 32307 Abstract An analysis of the recently published genome of Cytophaga hutchinsonii revealed an unusual collection of genes for an organism capable of degrading crystalline cellulose. Based on current literature, all known cellulolytic bacteria of industrial importance have the following structure: an N‐terminal catalytic domain, an adjacent cellulose binding domain (CBD), a Pro/Ser/Thr rich linker and another C‐terminal CBD. Cytophaga hutchinsonii cellulases differs from other cellulase enzymes by structurally not having a linker region or any CBD domains. The CBD is known to maintain a high concentration of the enzyme near the insoluble substrate, and to disrupt crystalline cellulose to aid hydrolysis. CBD has been considered as the limiting factor in hydrolysis. In the case of Cytophaga, since there is no CBD present, questions were being raised by cellulase scientists as to what mechanism this organism uses to degrade its insoluble substrates. A reliable model of Cytophaga β1‐4 Endoglucanase (Cel9A) was obtained by homology modeling based on a bacteria E4 X‐ray structure using the Swiss‐Model server. Conserved residues at the dimer interface were identified, of which the functional roles of two residues, namely Asp358 and Asp361, were determined by site‐directed mutagenesis. Four mutants were successfully generated and purified, three of which (D358A, D358B, D361A, D361B) were found to be inactive under various assay conditions. These results increase our understanding of the role of aspartate residues in protein function, and also help guide the choice of sites for other mutations in cellulase enzymes. 107


TECHNICAL ABSTRACTS

Tuesday, p.m.

Session Chair

1:45 p.m. – 2:05 p.m.

Technical Session 7 1:45 – 3:30 p.m. Graduate Student Sci‐Mix Symposium Sharon Kennedy, Ph.D. Colgate‐Palmolive Company Presenters

Aubert

Eastman Kodak Dr. Theophilus Sorrell Fellowship Awardee “Nanoparticle-Based Selective Colorimetric Sensor For Organophosphorus Pesticides” Tova A. Samuels* and Sherine O. Obare Department of Chemistry, Western Michigan University Kalamazoo, MI 49008 Abstract

Colorimetric sensors that selectively detect environmental pollutants in real time are becoming increasingly important areas of research. In particular, the design of materials that detect and discriminate between pollutants with similar molecular structures are in high demand. We have developed a series of colorimetric sensors based on silver (Ag), and gold (Au) metallic nanoparticles, and Ag/Au bimetallic nanoparticles. Particle size and shape were controlled through either photochemical or wet-chemical methods. The quality and the structure of the surface of the nanoparticles were found to play an important role in the detection process. The interaction of the nanoparticles with the pesticides ethion, malathion, parathion, fenthion and paraoxon was examined. We found that with proper control of particle size, these nanoparticles are highly selective toward OP pesticides, giving specific changes in optical signal. The sensors can be tuned to have up to ppb detection limits. The presentation will demonstrate the rational choices in substituent selection for selective discrimination between organophosphorus compounds. 108


TECHNICAL ABSTRACTS 2:05 p.m. – 2:25 p.m.

Dow Chemical Company Fellowship Awardee “Using Functionalized Nanoparticles To Study Intracellular Response Central To The Progression Of Osteonecrosis”

Fedena Fanord1, Korie Fairbairn1, Harry Kim2, Venkat Bhethanabotla1, Vinay K. Gupta*1 1University of South Florida, Department of Chemical & Biomedical Engineering, Tampa, FL 2Shriners Hospitals for Children, Tampa, FL Abstract Legg-Calvé-Perthes disease, a juvenile form of osteonecrosis, is a disorder of the femoral head that causes loss of the structural integrity of bone and deformity, often resulting in premature end-stage osteoarthritis. Current treatments are limited to high risk surgical procedures for young patients. Studies have shown that inhibiting osteoclastic resorption can prevent the development of the femoral head deformity; but much remains to be discovered about the molecular targets, uptake, and intracellular trafficking of the biochemicals that inhibit the osteoclastic resorption. We have focused on using functionalized gold nanoparticles (GNP) and exploiting the optical properties of the GNP for visual imaging of the progression of biochemical action on osteoblast and osteoclast cells. In vitro studies have been conducted to model in vivo cellular interactions and observe cellular response to functionalized GNP. Characterization of the functionalized GNP and cellular response with UV-Vis and infrared spectroscopy, dynamic light scattering (DLS), optical microscopy, and transmission electron microscopy (TEM) will be presented. 2:25 p.m. – Procter and Gamble Fellowship Awardee 2:45 p.m. “Next Generation Carbon Monoxide Gas Sensing” Adedunni D Adeyemo*1, Prabir K Dutta1 The Ohio State University, Department of Chemistry, Columbus, OH 43220 Abstract A large variety of metal oxide semiconductor (MOS) based sensors for the detection of carbon monoxide (CO) have been developed over the last few decades. These devices can only be been used at elevated temperatures (300-600oC), even for room temperature gas monitoring. The opportunity for a MOS device that does not require heating will lead to a low temperature and low cost device. A room temperature carbon monoxide sensor has been developed based on thin films of a ruthenium compound. The sensing properties are observed to be of a p-type “semiconducting” material in nature. The sensor material synthesis, optimization and sensing mechanism will be discussed. The ruthenium oxide sensors are sensitive to CO concentrations as low as 32ppm.

109


TECHNICAL ABSTRACTS 2:45 p.m. – 3:05 p.m.

Lendon N. Pridgen, GlaxoSmithKline ‐ NOBCChE Fellowship Awardee

“Overriding Diastereoselective Felkin Additions To Give Anti Felkin Products” Gretchen R. Stanton, Patrick J. Walsh* University of Pennsylvania Department of Chemistry, Philadelphia, PA 19104 Abstract Diastereoselective additions to chiral aldehydes have been widely utilized in the synthesis of small molecules and natural products. In general, additions to silyl‐protected α and β‐hydroxy aldehydes proceed through a non‐chelation (Felkin) controlled pathway. Chelation controlled (anti‐Felkin) additions to these aldehydes are uncommon due to the steric demands of the silyl group; the few examples in the literature employ a chiral ligand to achieve high selectivity.1, 2 There are limited examples of using organozinc reagents in additions to chiral aldehydes. In previous studies, we found that the addition of (Z)‐disubstituted vinyl zinc reagents to TBS‐ protected α and β‐hydroxy aldehydes give rise to the anti‐Felkin product in the presence of a Lewis acid (BF3⋅OEt), thus overriding the expected selectivity.3 More recently, we have shown that (Z)‐ trisubstituted vinyl zinc reagents add to various silyl‐protected α and β‐hydroxy aldehydes to give the anti‐Felkin addition product in high diastereomeric ratios. An equivalent of ethyl zinc bromide is a byproduct from the in‐situ formation of the vinyl zinc reagent (Figure 1). Figure 1 O TBSO

n-Bu

Br

i) Et2BH ii) Et2Zn, -78 oC -EtZnBr

H n-Bu

Et

OH Me

n-Bu

TBSO

ZnEt

H Me

Et

dr >20:1

After obtaining this unexpected addition product with reversed diastereoselectivity, we wanted to determine if the alkyl zinc halide byproduct plays a role in diastereoselection. In addition, we wanted to determine whether this is a more general procedure that could provide the synthetic community with a new, powerful tool. Preliminary results show that (S)‐2‐(tert‐ butyldimethylsilyloxy)‐propanal undergoes ethyl addition with excellent diastereoselectivity to give the anti‐Felkin addition product in the presence of ethyl zinc chloride (Figure 2). Figure 2 O TBSO

+ Me

Et2Zn

EtZnCl toluene, 0 oC to rt

OH

OH

TBSO

TBSO Me

Me

dr >20:1 anti-Felkin product obtained

110

product predicted by Felkin model


TECHNICAL ABSTRACTS The goal of this project is to create a general method for the generation of anti‐Felkin addition products from silyl‐protected α and β‐hydroxy aldehydes with a variety of zinc nucleophiles using an alkyl zinc halide additive. Further studies are underway to gain mechanistic insight. References (1) Williams, D. Angew. Chem. Int. Ed. 2003, 42, 1258‐1262. (2) Eidam, P.; Marshall, J. Org. Lett. 2004, 6, 445‐448. (3) Jeon, S.; Fisher, E.; Carroll, P.; Walsh, P. J. Am. Chem. Soc. 2006, 128, 9618‐9619.

3:05 p.m. – 3:25 p.m.

E.I. Dupont Fellowship Awardee “Inducer Effects On Lac Repressor‐Mediated DNA Loops: Single molecule FRET Studies” Kathy Goodson1*, Aaron R. Haeusler1, Doug English2, Jason D. Kahn1, 1University of Maryland College Park, College Park, MD, 20742, 2Wichita State University, Wichita, KS, 67260 Abstract

The Escherichia coli LacI protein represses the lac operon by blocking transcription. Tetrameric LacI binds simultaneously to a promoter‐proximal DNA operator and an auxiliary operator, andthe resulting DNA loop increases the efficiency of repression. A hyperstable closed‐form LacIDNA loop was previously shown to be formed on a DNA construct (9C14) that includes a sequence‐ directed bend flanked by operators. Previous bulk and single molecule fluorescence resonance energy transfer (SM‐ FRET) experiments on dual fluorophore‐ labeled 9C14‐LacI loops demonstrate that LacI‐9C14 adopts a single, stable, rigid DNA loop conformation, despite the presence of flexible linkers in LacI. Here, we characterize the LacI‐9C14 loop by SM‐FRET as a function of inducer isopropyl‐ ,D‐ thiogalactoside (IPTG) concentration. Energy transfer measurements reveal partial but incomplete destabilization of loop formation by IPTG, with no change in the energy transfer efficiency of the remaining looped population. 111


TECHNICAL ABSTRACTS Models for the regulation of the lac operon often assume complete disruption of LacI operator complexes upon inducer binding to LacI. Our work shows that even at saturating IPTG there is still a significant population of LacI‐DNA complexes in a looped state, in accord with previous in vivo experiments that show incomplete induction. Thursday, a.m. Session Chair

9:30 a.m. – 9:50 a.m.

Technical Session 8 9:30 ‐ 11:30 a.m. Parkview Alternative Energy Solutions Issac Gamwo, Ph..D. US Department of Energy Presenters “Redox Relays To Enhance Charge Separation Efficiency Of Photovoltaics”

Melody Kelley, Silas Blackstock* University of Alabama Department of Chemistry, Tuscaloosa, AL 35487 Abstract We are preparing redox relay dendrons (RRDs) as electron shuttle components of Grätzel type1 dye sensitived solar cells (DSSCs). The DSSC is a low cost alternative to solid‐state devices that convert sunlight to electricity. The RRD structures will improve solar energy capture by (a) preventing energy‐wasting charge recombination at the dye/semi‐conductor interface and (b) rapidly regenerating the dye component to its ground state to accep another photon. The structure, synthesis, and application of the RRDs are presented. 1. 1 OʹRegan ; Grätzel, M. Nature, 1991, 353, 737. “Reactivity Of Solvated And Presolvated “Dry” Electrons In The Ionic Liquid N‐Methyl N‐Butylpyrrolidinium Bis[(Trifluoromethyl)Sulfonyl]Imide” Jockquin D. Jones*(1), Charlene Lawson(1), Shawn M. Abernathy(1), James F. Wishart(2)

9:50 a.m. – 10:10 a.m.

(1)Howard University, Department of Chemistry, Washington, DC 20059, (2)Brookhaven National Laboratory, Department of Chemistry, Upton, NY 11972 Abstract Ionic liquids (ILs) are defined as salts with melting points below 100ºC. Because of their diverse properties, ILs have attracted widespread attention as promising alternatives to conventional (i.e., molecular) organic solvents. ILs are comprised entirely of cations and 112


TECHNICAL ABSTRACTS anions‐‐typically, a heterocyclic nitrogen‐containing cation and an inorganic anion. They are non‐volatile, non‐flammable, and highly conductive, which makes them attractive solvents for implementation in the Green Chemistry movement and improved chemical transformations. In order to fully evaluate their potential in new applications, it is imperative to study and understand their reaction kinetics using ionizing radiation. In this investigation, ultra‐fast pulse radiolysis was used to study the reactivity of the solvated electron in the ionic liquid N‐methyl N‐butylpyrrolidinium bis[(trifluoromethyl)sulfonyl]imide (P14NTf2) with selenate, cadmium, nitrate, and benzophenone scavengers. Using the Brookhaven National Laboratory (BNL) Laser‐ Electron Accelerator Facility (LEAF), we were able to directly observe the behavior of transient species on a pico‐ and nanosecond timescale. We analyzed ultrafast single shot traces of solvated electron absorbance for different scavenger concentrations at wavelengths of 680 and 800 nm. Reaction kinetics were obtained and it was determined that the nitrate ion is not an efficient dry electron scavenger in comparison to the cadmium and benzophenone scavengers. 10:10 a.m. – 10:30 “Continuous‐Flow and Enhancement of Reaction Rates of Biodiesel Production Using a Slit‐Channel Reactor” a.m. Egwu Eric Kalu1*, Ken S. Chen2, Tom Gedris3 1FAMU‐FSU COE, Chemical & Biomed. Dept., Tallahassee, FL 32310 2Sandia National Laboratories, Albuquerque, NM 87185 3Florida State University, Chemistry & Biochemistry Dept., Tallahassee, FL 32306 Abstract Slit‐Channel reactors are reactors whose active surface areas are orders of magnitude higher than those of micro reactors but have low fabrication costs relative to micro reactors. We successfully produced biodiesel with different degree of conversion using liquid‐phase catalyst in the slit‐channel reactor. The slit‐channel reactor conversion performance shows that percent conversion of soybean oil to biodiesel increases with channel depth, as expected, due to more efficient mixing. As the channel becomes shallower, the reaction becomes faster. Results will be presented to show that the slit‐ channel reactor provides an improved performance over traditional batch reactors using NaOH liquid catalyst. In the present work, the slit‐channel reactors were developed with the objective to couple the reactors with solid catalysts in converting soybean oil to biodiesel and discussion will be given on methods of implementation. 10:30 a.m. – 10:45 Break a.m. 10:45 a.m. – 11:05 a.m. 113


TECHNICAL ABSTRACTS 10:45 a.m. – 11:05 “Electroless Nickel‐based Catalysts for Hydrogen Generation by Hydrolysis of Borohydride” a.m. Shannon Anderson, Addisu Samuel, Egwu Eric Kalu*, Department of Chemical & Biomedical Engineering FAMU‐FSU College of Engineering Tallahassee, FL 32310 Abstract Catalysts based on electroless nickel nanoparticles were developed for the hydrolysis of sodium borohydride for hydrogen generation. The Ni‐based catalysts were synthesized by polymer‐stabilized Pd nanoparticle‐catalyzation and activation of Al2O3 or TiO2 substrate and electroless Ni or Ni‐Mo plating of the substrate for selected time lengths. Catalytic activity of synthesized catalysts was tested for the hydrolyzation of alkaline‐stabilized NaBH4 solution for hydrogen generation. The effect of palladium loadings on the substrate and electroless plating time lengths on hydrogen generation rates is analyzed and discussed. Compositional analysis and surface morphology were done for metallized Al2O3 or TiO2 particles using SEM and EDAX. Apparently, for the conditions studied, two‐stage hydrogen evolution rates describe the hydrogen‐time curves – the high catalytic activity stage that is followed by the low catalyst activity stage. Further, within the limited range of variables investigated, 85μg Pd/g substrate loading and nickel plating time of 5 minutes yielded the best hydrogen generation rates. Suggestions are provided for further work needed prior to using the catalyst for portable hydrogen generation from alkaline‐stabilized NaBH4 solution. “Fuel Reactor Behavior Of A Chemical Looping Combustion 11:05 a.m. – 11:25 System: Thermal Effects” a.m. Isaac K. Gamwo1 and Jonghwun Jung2 1U.S. Department of Energy National Energy Technology Laboratory Pittsburgh, PA 15235‐094 2Technical Research Laboratory, POSCO, 1, Goedong‐dong, Nam‐gu, Gyeongbuk 790‐785, Pohang, South Korea Abstract Energy source forecasts show that fossil fuels will remain the primary energy source worldwide leading both renewable and nuclear energy sources at short or medium term. 114


TECHNICAL ABSTRACTS However, fossil fuel combustion for power generation increases atmospheric CO2 concentration. Hence, it is important to develop new technologies during this decade that will reduce the impact of continued fossil energy use while cleaner energy sources are being developed. Chemical looping combustion (CLC) is a good candidate for fossil fuel combustion with negligible atmospheric CO2 emissions. CLC produces a relatively pure stream of CO2 ready for compression and storage in geological settings. Furthermore, CLC also minimizes NOx emissions since the fuel combustion is flameless in the absence of nitrogen. Our previous studies simulated the fuel reactor behavior of a chemical looping combustion process. Here, we report on the thermal effects on the fuel reactor behavior. We found that unburned fuel weight fraction was reduced by nearly half when the temperature increased from 700 0C to 900 0C indicating a substantial increase in the fuel conversion rate. The simulations also showed that the bubble size in the fuel reactor increases with temperature. Thursday, p.m.

Session Chair

9:30 a.m. – 9:50 a.m.

Technical Session 9 Portland/Benton 9:30 – 12:00 N Tools and Technologies in Analytical Chemistry I Emanuel Waddell, Ph.D. Department of Chemistry, Oakwood University Presenters “The Effects Of Varying Ionic Strengths Of Supporting Electrolytes On A Spectroelectrochemical Sensor”

Eme E. Amba*, Laura K. Morris, Sara E. Andria, Chris Bowman, Carl J. Seliskar and William R. Heineman. Department of Chemistry, University of Cincinnati, 301 Clifton Court, Cincinnati, OH 45221‐0172 Abstract The effects of varied ionic strengths of supporting electrolytes on a spectroelectrochemica sensor were studied. The spectroelectrochemical sensor is an optically transparent indium tin oxide (ITO) electrode coated with a charge selective thin film that contacts a sample solution. To be detected, the analyte partitions into this ion exchange film where i undergoes a modulated change in absorbance upon reversible oxidation‐reduction at the ITO electrode. The change in absorbance is measured using attenuated total reflectance 115


TECHNICAL ABSTRACTS (ATR) spectroscopy and is related to the concentration of analyte which has partitioned into the film. The model system was tris (2,2‐bipyridyl) ruthenium (II) dichloride hexahydrate ([Ru(bpy)3]2+) partitioning into a sulfonated polystyrene‐block‐poly (ethylene‐ran‐ butylene)‐block polystyrene (SSEBS), an ion exchange thin film. Analyte solutions were prepared with either potassium nitrate, sodium nitrate or calcium nitrate as the supporting electrolyte. The analyte was kept at a constant concentration of 10‐4 M and supporting electrolyte concentrations were varied from 0 M to 1 M. The performance of the sensor was evaluated using cyclic voltammetry to repeatedly cycle between [Ru(bpy)3]2+, which absorbs at 450 nm, and non‐absorbing [Ru(bpy)3]3+ (700 mV to 1300 mV vs. Ag/AgCl). Both the optical response ( A) and electrochemical peak currents (Ip) were affected by changing the concentration of supporting electrolyte. At high concentrations of supporting electrolyte, both A and Ip were decreased. The optimal ionic strength of the supporting electrolyte for the three electrolytes were: 0.001M for NaNO3, 0.01M for KNO3 (0.01M) and 0.003M for Ca(NO3)2 (0.001M). At concentrations of supporting electrolyte near zero, the sensor’s optical response decreases by approximately 37%. The optical response signal was plotted against concentration, ionic strength and conductivity, a parameter of all ions that is dependent on concentration. 9:50 a.m. – 10:10 “Novel Near Infra‐Red Dyes And Nanoparticles Derived From Ionic Liquids” a.m. David K. Bwambok1, Bilal El‐Zahab1, Mark Lowry1, Gabor Patonay2, Gary A. Baker3, and Isiah M. Warner*, 1 1Department of Chemistry, Louisiana State University, Baton Rouge, LA, 70803 2Department of Chemistry, Georgia State University, Atlanta, GA, 30302 3Chemical Sciences Division, Oak Ridge National Laboratory, Oak Ridge, TN, 37831 Abstract Dyes that fluoresce in the NIR region have enormous potential applications in areas such as laser dyes, organic light‐emitting diodes (OLED), invisible printing inks, probes for photodynamic therapy and contrast agents for in vivo imaging. We have synthesized and investigated spectral properties of novel near infra‐red (NIR) dyes and NIR dye nanoparticles derived from ionic liquids (ILs). The ionic liquid NIR (IL NIR) dyes were synthesized using an anion exchange metathesis reaction between the cationic dye halides such as iodide or chloride and different anions. A simple reprecipitation method was used to prepare the IL NIR dye nanoparticles. The size of the nanoparticles as determined using dynamic light scattering as well as electron microscopy suggests that particles of around 100 nm in diameter were obtained. The IL NIR dyes and their respective nanoparticles studied have absorbance and fluorescence emission in the NIR wavelength region. These IL 116


TECHNICAL ABSTRACTS NIR dyes offer the capability of tuning the absorption and fluorescence properties by varying the anion. In addition to other applications associated with common NIR dyes, we envision that these IL NIR dye nanoparticles may have potential application in biomedical imaging because body tissues have a low absorption coefficient in the long NIR wavelength region allowing light to penetrate deep into the tissues. In addition, the dye nanoparticles are derived from ILs which are generally considered as a non‐toxic class of compounds consisting of only ions; a crucial requirement for dyes to be used for in vivo imaging. In addition, the possibility of tuning the properties of the IL NIR dyes by varying the anion is a tremendous advantage for this new class of nanomaterials. “Supercritical Fluid Chromatography Study Of Anion 10:10 a.m. – 10:30 Influence On Retention Mechanisms Using Surface‐Confined a.m. Ionic Liquids” Nyote J. Oliver, David S. Van Meter, Thomas L. Chester, Apryll M. Stalcup* University of Cincinnati, Department of Chemistry, P.O. Box 210172, Cincinnati, OH, 45220 Abstract Mass spectrometry is increasingly important in the analysis of biological samples, such as proteins, lipids and oligonucleotides. However, the chromatographic conditions required for the separation can have a deleterious effect on the mass spectrometer. For that reason, this project investigates the use of surface‐confined ionic liquids (SCIL) stationary phases on supercritical fluid chromatography (SFC) platforms, to compliment ongoing studies using high performance liquid chromatography (HPLC), to offer an alternative approach to complex biomolecular separations. SCILs are emerging as a potential answer to the challenges of biomolecular separations because these types of compounds have many interaction modes, thus making them capable of separations through electrostatic, dispersive and proton acceptor‐ donor interactions. Previous studies of SCILs have shown that the anion seems to play a role in the retention of various analytes through its exchange with adventitious ions in the mobile phase. The use of SFC for this study is necessary because the anion remains on the column and its contribution to the retention properties of the column can be studied more closely. Therefore, use of SCILs with SFC would address the shortfalls in separations of complicated biological mixtures introduced to the mass spectrometer. 10:30 a.m. – 10:45 Break a.m. 117


TECHNICAL ABSTRACTS 10:45 a.m. – 11:05 “Increased Light Extraction Of Inasgasb Led Through Wet Chemical Etching” a.m. Deandrea L. Watkins*, Jonathon T. Olesberg, Thomas F. Boggess, and Mark A. Arnold The University of Iowa Chemistry Department, Iowa City, IA, 52242 Abstract Near infrared spectroscopy is under development for measuring glucose and other bio‐ molecules in biological fluids at wavelengths between 2.0 and 2.5 μm. High quality spectra are needed to successfully extract analytical information from near infrared spectra collected from clinical samples. A solid‐state near infrared spectrometer would advance the field by providing a means for collecting high quality spectra under non‐laboratory conditions. We are developing solid‐state light emitting diode (LED) sources from unique GaInAsSb semiconductor materials. Physical geometry of the LED region is a critical parameter and the physical geometry depends on many factors associated with the etching process, such as composition of the etching solution, relative concentrations of the etching components, and time of the etching reaction. This presentation will focus on the optimization of the etching solution to produce LED’s with high radiant powers. Results indicate that the depth of etching and the angle of the etched sidewalls can be optimized by controlling the etching conditions. Through this optimization of etch solution composition there was an increase in etch depth from 18.20 μm to 60.4 μm and an increase in etch rate from 0.61 μm/min. to 2.01 μm/min. when etched for a period of 30 minutes. 11:05 a.m. – 11:25 “Ters Of Quinolinium Tricyanoquinodimethanides On Silver” a.m. Melissa Fletcher,1 D. M. Alexson,2 Sharka Prokes,2 Orest Glembocki,2 Alberto Vivoni,3 and Charles Hosten1* 1Department of Chemistry, Howard University, Washington DC, 20059 2Naval Research Laboratory, Washington DC, 20375 3Department of Biology, Chemistry, and Environmental Sciences, Inter American University, San German, PR 00683‐9801 Abstract The alkylquinolinium tricyanoquinodimethanide class of compounds has been studied and classified as molecular rectifiers. The extended ‐ring system allows for facile, unidirectional electron transport, i.e. rectification. The alkyl tails attached to the quinolinium ring aid in Langmuir‐Blodgett film formation. Tip‐enhanced Raman scattering (TERS) spectroscopy has been used to study the orientations of monolayers of N‐ methylquinolinium tricyanoquinodimethanide and 6‐thioacetyl‐N‐hexylquinolinium 118


TECHNICAL ABSTRACTS tricyanoquinodimethanide. The results indicate that both of the monolayers are adsorbed through the lone pairs on the nitrogen atoms. However, upon removal of the acetyl group, leaving a free sulfur, some of the monolayer tends to reorient itself, adsorbing to the surface via a S–Ag bond. 11:25 a.m. – 11:45 “Surface Modification Of Polymer Substrates By Excimer Radiation” a.m. Holly Carrell1, Stephen Shreeves2, Christopher Perry3, and Emanuel Waddell*2 1University of Alabama in Huntsville, Department of Chemistry, Huntsville, AL 35899 2Oakwood University, Department of Chemistry, Huntsville, AL 35896 3Loma Linda University, School of Medicine, Department of Biochemistry, Loma Linda, CA 92350 Abstract Surface modification of polymer substrates is typically achieved by “wet‐ chemical” treatments that involve a number of time‐consuming steps. Previously we investigated the ability to pattern polymer substrates via laser ablation under different chemical atmospheres. In this one‐step process, polymers were micro‐machined while simultaneously chemically modifying the surface. As an extension of this research, we have exposed various polymer substrates to narrow band excimer radiation under inert atmospheres and the resultant surface is characterized by attenuated total reflectance infrared spectroscopy, contact angle goniometry, atomic force microscopy, and scanning electron microscopy. Finally, some of the polymer substrates as characterized by electroosmotic flow. In this presentation, the modification of polydimethylsiloxane and polymethylmethacrylate will be discussed. The modification of polydimethylsiloxane (PDMS) by narrow band 254 nm excimer radiation under a nitrogen atmosphere is characterized and it is determined that the UV irradiation results in the formation of the carboxylic acids that influences the wettability of the surface. Continued exposure results in the formation of an inorganic surface (SiOx, (1 < x < 2)) which hinders the ability to continually increase the wettability. These results have implications in the fabrication and chemical modification of microfluidic or micro‐electro‐mechanical systems. The application in microfluidics is observed with the modification of PMMA by 222 nm excimer radiation that results in the formation of hydroxyl groups which in turn contribute to increased electroosmotic flow. 119


TECHNICAL ABSTRACTS

Thursday, a.m.

2009 Rohm and Haas Undergraduate Competition Co‐sponsored by Colgate‐Palmolive Company and Lubrizol Corporation 10:00 – 12:00 N

Pershing/Lindel l

Session Chair Presenters 10:00 a.m. – 10:20 2009 Rohm and Haas Undergraduate Award Winner a.m. “Novel Graphene Nanocutting Approach Through Controlled Fracture” Rhonda Jack*,§, Dipanjan Sen*, Markus J. Buehler*,† * Laboratory for Atomistic and Molecular Mechanics, Department of Civil and Environmental Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA § Department of Chemical Engineering, Hampton University, Hampton VA, USA † Corresponding author, electronic address: mbuehler@MIT.EDU Abstract The recent discovery of single graphene sheets and the remarkable technologies envisioned for graphene‐based materials necessitate the ability to assemble and reproduce nano‐precise graphene structures. We demonstrate the possibility of creating atomically precise graphene structures by applying tensile load to single sheets of graphene, using atomistic models of single graphene sheets. These models are generated by the Reactive Force Field potential (ReaxFF) which was incorporated into the General Reactive Atomistic Simulation Program (GRASP). It is observed that the direction and behavior of graphene fracture are controlled to a significant extent by the presence of atomistic defects in the form of atom vacancies throughout the sheet. These vacancies produce varied effects according to the patterns in which they occur throughout the 2D structure. This overall realization engenders novel possibilities with methods either currently employed or proposed, that are aimed at producing atomically precise graphene structures, and thereupon brings great promise in advancing new applications predicated on graphene nano technology. 10:20 a.m. – 10:40 2009 Rohm and Haas Undergraduate Award Winner a.m. “Coupled Dielectric And Thermochemical Studies Of The Influence Of Curing Agent Structure On Epoxy‐Amine Cure” 120


TECHNICAL ABSTRACTS Abdul‐Rahman O. Raji*, Alvin P. Kennedy, and Solomon Tadesse Morgan State University, Department of Chemistry, Baltimore, MD 21251 Abstract Dielectric spectroscopy and differential scanning calorimetry have been used to monitor the isothermal cure of Diglycidyl Ether of Bisphenol A with 3, 3ʹ‐DDS and 4, 4ʹ‐DDS. Combination of both methods provides a powerful technique for understanding the morphology of network‐forming epoxy‐amine during cure. It is interesting that though the only difference in the structure of both curing agents is the location of their amine groups, there is a significant difference in their final glass transition temperature. Their in‐ situ dielectric properties also showed huge distinctions. The result of the experiments revealed that although the rate of reaction or the rate of network formation is higher for the 3, 3ʹ‐DDS, it is not directly responsible for the disparity in the final glass transition temperature. 10:40 a.m. – 11:00 2009 Colgate‐Palmolive Undergraduate Award Winner a.m. “Asymmetric Conjugate Addition: Synthesis Of (+)‐Kalkitoxin” Everett W. Merling, Nina R. Collins and Richard J. Mullins* Department of Chemistry, Xavier University, Cincinnati, OH Abstract The lipopeptide (+)‐kalkitoxin, a metabolite produced by a member of the Lyngbya majuscula family of cyanobacteria, has been shown to exhibit several antiproliferative biological properties. The most noteworthy of these properties is its cytotoxicity to an array of aquatic creatures as well as toxicity to rat neurons and human colon cancer cell lines. On the basis of this interesting bioactivity profile, we have embarked on a quest to better understand the manner by which it prevents the growth of tumor cells. To accomplish this goal, our efforts have focused on the total synthesis of kalkitoxin, utilizing the conjugate addition of an allylic stannane for preparation of the aliphatic core. Our progress, which has thus far resulted in preparation of the aliphatic core of the parent molecule, will be presented. 11:00 a.m. – 11:20 2009 Colgate‐Palmolive Undergraduate Award Winner a.m. “Synthesis Of Chalcone Derivatives For Use As Anti‐Proliferative Agents On Glioblastoma Cells” Debra Ragland and Marion A. Franks, Ph.D.* Department of Chemistry, North Carolina Agricultural and Technical State University, Greensboro, North Carolina 27411. 121


TECHNICAL ABSTRACTS Abstract Chemoprevention explores the use of natural and synthetic agents that can reduce the incidence of cancer. The goal of our chemoprevention research is to synthetically produce chemopreventive compounds that can halt or reverse the development of cancer in people that are exposed to carcinogens on a daily basis. Chalcones which are the biogenetic precursors for flavones have been investigated in many experiments for their anti‐ proliferative and chemopreventive effects. Chalcones and their derivatives are useful as angiogenesis inhibitors, anti‐tumor, and anti‐cancer agents and are used to treat a number of conditions or disease states in which angiogenesis is a factor. We hypothesize that based on their anti‐angiogenic nature, chalcone derivatives formulated by synthetic means will have anti‐proliferative effects on glioblastoma cells. Chalcones were prepared by Claisen‐Schmidt condensation of primarily 3’ and 4’ methoxy‐acetophenone and substituted aldehydes. The reactions produced several crystalline solids in medium to high yields ranging from 60% to 98%. The solid products were tested for purity using Gas Chromatography – Mass Spectroscopy (GC‐MS) and 1H and 13C NMR. Each purified products were tested for their anti‐proliferative effects on glioblastoma cells (U‐251) in varying concentrations. The tested chalcones showed low to moderate anti‐proliferative effects on the U‐251 Glioblastama cell line. This work was generously supported by the Agilent Technologies Diversity Grant ID#: [08US‐827FD]. 11:20 a.m. – 11:40 2009 Lubrizol Corporation Undergraduate Award Winner a.m. “The Effect Of Solvents On The Rheology Of Polymer Solutions” Folorunso S. Adu and Jude O. Iroh University of Cincinnati, Cincinnati, Ohio Abstract The polymer used in this study is poly(dimethysiloxane)‐ethermide (PSEI). Films were made with this polymer buy dissolving it in the appropriate solvents. The solvents used are NMP and THF. To study for the rheological behavior of the polymer solutions, their viscosities were measured. Viscosity measurement was done using the simple shear method with the Brookfield viscometer, which consists of a concentric cylinder system. The measured viscosity was shown to be dependent on the temperature, shear rate, shear stress, and concentration of the solution. Our preliminary results, showed that generally for the polymer‐NMP solutions, as the temperature increased the viscosity decreased. While for the polymer‐THF solutions the viscosity decreased initially with increased temperature up to the boiling point of the solvent followed by a drastic increase in viscosity for any additional increase in temperature. These observations gave us a powerful insight into how processing temperature affects the processing of thin films, membranes, and coatings. 122


TECHNICAL ABSTRACTS 11:40 a.m. – 12:00 2009 Lubrizol Corporation Undergraduate Award Winner N “The Synthesis Of Coumarins For Prostate Cancer Chemoprevention” B. Mills & M. A. Franks, Ph.D.* Department of Chemistry, North Carolina A & T State University 1601 E. Market Street, Greensboro, NC 27411 Abstract Cancer is a group of diseases characterized by the growth of uncontrolled abnormal cells leading to the impairment of normal bodily functions. A total of 1,437,180 new cancer cases and 565,650 deaths from cancer are projected to occur in the United States in 2008. One of the most promising avenues for controlling cancer is through “chemoprevention”. Chemoprevention is the use of natural, synthetic, or biological chemical agents to reverse, suppress, or prevent carcinogenesis. It has been shown that coumarins and boronic acids are effective chemopreventive treatments when used to treat carcinogenic prostate cancer cells. I hypothesize that through the use of coumarins and boronated derivatives of coumarins, prostate cancer will be prevented. I synthesized numerous coumarin derivatives for chemopreventive testing using a green chemistry, solventless preparation technique, and indium chloride as the catalyst. Thus far, we have characterized and purified several coumarins and derivatives using IR, GC‐MS, and NMR spectroscopy. The compounds that are synthesized and purified will be assayed for chemopreventive activity against prostate cancer cell lines. We are currently in the process of synthesizing the boronic acid analogs of selected coumarins, which will be tested for their chemopreventive activity against prostate cancer cell lines as well.

Thursday, p.m.

Technical Session 10 1:00 – 5:00 p.m. Portland/Bento Tools and Technologies in Analytical n Chemistry II Session Chair Aleeta Powe, Ph.D., University of Louisville Charlotte Smith‐Baker, Texas Southern University Presenters “Mass Spectrometric Studies Of Hyaluronic Acid In The 1:00 p.m. – Vitreous Humor” 1:25 p.m. 123


TECHNICAL ABSTRACTS Aleeta M. Powe* University of Louisville, Department of Chemistry, Louisville, KY 40208 Abstract Hyaluronic acid, a sugar polymer, is the predominant macromolecule of the transparent, gel‐like vitreous humor, which is 80% of the volume of the mammalian eye. The liquification of vitreous occurs with age, in a variety of ocular disease states, and is important in the pathogenesis of retinal tears and detachments. In this study, we investigate and identify saccharides in the vitreous and regionally map the occurrence of the saccharides, with particular focus on Hyaluronic acid. Saccharides of Hylauronic acid were identified from 4 different regions (anterior, posterior, middle and rear) of porcine vitreous using FTICR‐MS. Specific saccharides’ structures (disaccharides, tetrasaccharides, hexasaccharides) were identified using Tandem MS. Saccharides’ masses were compared before and after depolymerization of hyaluronic acid. Changes in hyaluronic acid saccharides possibly can be correlated to specific syndromes or diseases of the eye. “Sequencing Antimicrobial Polypeptides From The American 1:25 p.m. – Alligator (Alligator Mississippiensis) Blood Using Mass Spectrometry” 1:45 p.m. Lancia N.F. Darville*1, Mark E. Merchant2 and Kermit K. Murray1 1Louisiana State University, Baton Rouge, LA, 70803, USA and 2McNesse State University, Lake Charles, LA, 90455 Abstract Significant anecdotal evidence exists to suggest that alligators and crocodiles are resistant to microbial infection. These animals typically live in environments with large concentrations of pathogenic microbes, yet their wounds typically heal without infection. Alligator leukocytes contain cationic peptides that are believed to be responsible for the strong antimicrobial activity against bacteria, virus and fungi. To begin to understand the structure and function of the peptides within the alligator’s blood that contribute to the antimicrobial activity we sequenced polypeptides from their leukocyte using de novo sequencing. Alligators were captured and blood was drawn from internal jugular vein. Leukocytes were collected from the whole blood by homogenizing, centrifuging and diluting the supernatant in 0.1% acetic acid. Alligator leukocyte was separated using a 1D gel format. Gels were stained with Coomassie blue and low molecular weight protein bands were excised and enzymatically digested. The masses of the peptides from the enzymatic digest were measured using LC‐MS/MS. Predictions of polypeptide sequences were determined using automated and manual de novo sequencing analysis. Predicted peptide sequences were also searched using MASCOT with NCBInr and MSDB database 124


TECHNICAL ABSTRACTS to identify any peptides that are closely homologous. The study and characterization of these polypeptides will lead us to the specific peptide(s) that contribute to the innate immune system in the American alligator. These peptides will potentially offer a route to new antifungal and antibacterial drugs. “The Potential Of Optically Gated Vacancy Capillary Electrophoresis 1:45 p.m. – As An Innovative Technique To Study Enzymatic Reactions” 2:05 p.m. Sherrisse A. Kelly, Rattikan Chantiwas, Douglass Gilman* Louisiana State University, Department of Chemistry, Baton Rouge, LA 70803 Abstract It is well known that enzymes are vital to the function of our bodies. Enzymes are proteins that serve as catalysts for important biological reactions to take place however, improper functioning of certain enzymes can lead to illness and disease. Enzymes react with substrates to produce specific reaction products. The analytical technique, optically gated vacancy capillary electrophoresis (OGVCE), will be developed to analyze such reactions. For the initial studies, the enzyme adenosine deaminase (EC 3.5.4.4) has been examined as a model system to demonstrate this technique. A fluorescent substrate for the enzyme, 2ʹ, 3’‐O‐(2, 4, 6 trinitrophenyl) adenosine (TNP‐adenosine), has been successfully synthesized and characterized. The ability of the substrate to react with the enzyme and form a fluorescent product was confirmed using capillary electrophoresis with laser‐induced fluorescence detection. The OGVCE technique is very promising for allowing researchers to study the activity and inhibition of enzymes. This will lead to a better understanding of certain enzyme systems and has the potential of assisting researchers in the drug discovery process in the future. “Protein Separations Using Polyelectrolyte Multilayer Coatings In 2:05 p.m. – Open Tubular Capillary Electrochromatography And Gradient Elution 2:25 p.m. Moving Boundary Electrophoresis” Candace A. Luces1, David Ross2, Mark Lowry1, Bilal El Zahab1, Laurie Locascio2, and Isiah M. Warner*1 1Department of Chemistry, Louisiana State University, Baton Rouge, LA 70803 2Chemical Science and Technology Laboratory, National Institute of Standards and Technology, Gaithersburg, MD. 20899 Abstract In this study, polyelectrolyte multilayer coatings were constructed using molecular micelles in open tubular capillary electrochromatography (OT‐CEC) and gradient elution 125


TECHNICAL ABSTRACTS moving boundary electrophoresis (GEMBE) for protein separations. In OT‐CEC, the proteins were detected using both ultra violet (UV) and laser induced fluorescence (LIF) detection, while only LIF detection was used in the GEMBE technique. PEM coatings were constructed using the cationic polymer, poly‐L‐ornithine and the molecular micelles sodium poly(N‐undecanoyl‐L‐leucyl‐alaninate) (poly‐L‐SULA) and sodium poly(N‐ undecanoyl‐L‐leucyl‐valinate) (poly‐L‐SULV), for the enhancement of protein separations in OT‐CEC. Poly‐L‐SULA was the only molecular micelle used in PEM coatings for GEMBE. The effects of bilayer number, type of molecular micelle used in the PEM coatings as well as pH of the background electrolyte on acidic proteins (α‐lactalbumin, β‐ lactoglobulin A, β‐lactoglobulin B, albumin, myoglobin, and deoxyribonuclease I) were analyzed using ultra violet (UV) detection in OT‐CEC. In addition, a comparison of the electropherograms of native proteins to those of fluorescently labeled proteins was completed using PEM coated capillaries in OT‐CEC with UV detection. Furthermore, the influence of pH of the background electrolyte, internal diameter and the effective length of the capillary were studied to investigate their influence on protein separations with LIF detection. For LIF detection, the proteins were fluorescently labeled using 5‐ (Iodoacetamido) fluorescein (5‐IAF). High resolution protein separations were achieved in OT‐CEC using PEM coatings constructed with 2 bilayers of poly‐L‐ornithine and poly‐ L‐SULA as well as a 40 mM phosphate, pH 8.0 buffer. These conditions were also used for protein separations with the GEMBE technique. Different voltages and step intervals were applied to a 3cm, 30μm capillary to investigate their influence on protein separations using PEM coatings and GEMBE. As expected, the results showed that lower voltages and step intervals produced higher resolution protein separations. 2:25 p.m. – “Toward A Theory Of Achiral Molecular Micelle‐Protein Complexation: Analysis Of The Interaction Of Proteins With Poly (N‐ 2:45 p.m. Undecylenic Sulfate)” Monica R. Sylvain*1, Bilal El‐Zahab1, Mark Lowry,1 Isiah M. Warner1 1Department of Chemistry, Louisiana State University, Baton Rouge, LA 70803 Abstract Routinely, polyacrylamide gel electrophoresis (PAGE) uses sodium dodecyl sulfate (SDS) to determine the polypeptide composition of proteins. In this technique the SDS‐ polypeptide complexes formed are subjected to an electric field, migrate toward the anode, and are separated according to molecular weight. At the molecular level, several types of hydrophobic and ionic interactions are involved in protein‐SDS association. Under certain conditions, the type of interaction primarily responsible for association has been shown to depend on surfactant concentration as well as other system parameters such as ionic strength and pH. In our laboratory, a novel variation of SDS‐PAGE has been developed wherein the molecular micelle, poly (N‐undecylenic sulfate) [poly‐SUS], functions as the denaturing surfactant. We proposed that the efficacy of the separations 126


TECHNICAL ABSTRACTS with poly‐SUS will be defined by the interaction mechanism involved with the proteins. Herein, we report on the analysis of the effect of poly‐SUS on the conformation, stability, and hydrodynamic radius of proteins separated in PAGE. Break 2:45 p.m. – 3:00 p.m. “Fabrication With Chitosan For Biosensors” 3:00 p.m. – 3:25 p.m. Yongchao Zhang* Morgan State University, Chemistry Department, Baltimore, MD, 21251 Abstract Chitosan as a biocompatible and bio‐degradable polymer which has excellent film‐ forming abilities has attracted much attention recently, for promising applications in biosensors. In this study we developed new techniques in fabricating chitosan matrix for immobilizing biomolecules and metal nanoparticles. A non‐toxic crosslinker was used to effectively crosslink chitosan and the enzyme; an innovative electrode‐induced crosslinking method was also developed which provided simple, fast, precise and controllable fabrication of chitosan/enzyme films on electrode surface. Chitosan was also found to be crucial in assisting and regulating the electrochemical synthesis of metal nanoparticles such as Ag NP; the Ag nanoparticles showed excellent ability to enhance the sensitivity of the electrochemical biosensor based on the chitosan/silver NP/enzyme composite material. Other properties of the chitosan/silver NP composites are currently under investigation. Supported by NSF HRD‐0627276. 3:25 p.m. – “The Development Of A Colorimetric Cyanide Anion Sensor In Aqueous Solutions” 3:50 p.m. Yousef M. Hijji*, Belygona Barare Chemistry Department, Morgan State University, Baltimore MD 21251 Abstract Cyanide is one of the most toxic anions around us. It can contaminate our water sources and environment. Cyanide contamination is usually caused by industrial waste from gold extraction process and as fishing agent. Due to the serious threat of cyanide 127


TECHNICAL ABSTRACTS contamination, the development of efficient sensitive method for its monitoring and determination is of urgent need. We have developed a visual colorimetric method for qualitative and quantitative determination of cyanide in aqueous solution at micro‐molar levels. The detection process and the method of evaluation will be discussed. Support was provided by NSF‐RISE Award No. HRD‐0627276. “Spectroscopic Investigations Of Heterogeneous Wetting And 3:50 p.m. – Molecular Delivery From Nanoporous Silica Particles” 4:10 p.m. Reygan M. Freeney*1, Mark A. Lowry2, and M.Lei Geng1 1University of Iowa, Department of Chemistry and the Nanoscience and Nanotechnology Institute, Iowa City, IA 52242 2Louisiana State University, Department of Chemistry, Baton Rouge, LA, 70803 Abstract With the broad applications of nanomaterials in science and technology, there is an increased interest in the understanding of transport and dynamics at the nanometer dimensions. Recently, much discussion has occurred regarding the diffusion and sorption processes of a variety of silica‐based materials, which have broad applications in many fields such as drug delivery, catalysis, and chemical separations. The interest in mesoporous silica is due to its ability to offer tunable diameters, pore sizes, volumes, and surface modifications. These silica particles are also strong and stable, offer a large surface area, do not shrink or swell, resist pH changes and yield highly reproducible results. The porous silica particles are durable, inert, and compatible to biological applications. To better understand the process of diffusion out of nanopores, an investigation of the transport of Rhodamine 6G, a fluorescent cationic dye, is used as a molecular probe for the nanostructured silica material. Through surface modification, the mesoporous silica beads contain a monolayer of octadecylsilane and possess a nominal diameter of 10 μm with an average pore size of 10 nm. These particles were loaded with R6G through a method of immersion; molecular diffusion of the dye was monitored using confocal microscopy and UV‐Vis spectrophotometry to measure the change in fluorescent intensity or absorbance over time. Solvent compositions were varied to determine how the diffusion rate is influenced by the organic content. Preliminary results show that the higher the organic content, the faster the diffusion rate. A comparison between different surface modifications is also included in this study. 4:10 p.m. –

“Near‐Infrared Spectroscopy And Imaging Investigation Of 128


TECHNICAL ABSTRACTS 4:30 p.m.

Single‐Walled Carbon Nanotubes In Ionic Liquids” 1 Kristen E. Schexnayder , Chieu Tran*2, Irena Mejac2, Simon Duri2

1Louisiana State University, Department of Biological Sciences, Baton Rouge, LA 70803 2Marquette University, Department of Chemistry, Milwaukee, WI 53201 Abstract Single‐walled carbon nanotubes have become an explosive research interest among many areas of chemistry including analytical chemistry during recent years. They will provide numerous technological advances in several different realms of research. Ionic liquids are also of much interest during recent years because they have many unique properties allowing for widespread use and development as a ʺGreen and Recyclable Solvent.ʺ Single‐walled carbon nanotubes are known to be soluble in only a few selected solvents. Ionic liquids with their high solubility power may serve as possible solvents for single‐ walled carbon nanotubes. This would lead to the development of many new applications for the carbon nanotubes which are not possible otherwise. To test this possibility, we initially dissolved single‐walled carbon nanotubes in dimethylformamide and characterized the solution using near‐infrared spectroscopy and near‐infrared multispectral imaging techniques, similar to procedures used previously in our laboratory. We found that the DMF solution of carbon nanotubes exhibits an absorption band at around 1862nm which is in good agreement with those reported in literature. Single‐walled carbon nanotubes were then mixed with a small volume of a room temperature ionic liquid and sonicated using a bath sonicator. After a few hours of sonication, an additional amount of ionic liquid was added to create a 1:1 ratio. The sample continued to sonicate for a few hours until a thorough dispersion was visible. A small volume of this solution was transferred to ionic liquid to create a diluted solution with a concentration of 0.02mg/mL. Near‐infrared spectroscopy and imaging systems were used to characterize the ionic liquid solution. Preliminary results are encouragement and with the use of various different types of ionic liquids, it will be possible to dissolve single‐walled carbon nanotubes in some room temperature ionic liquids. These possibilities are currently under investigation. “Hair As An Indicator Of Exposure To Pesticides” 4:30 p.m. – 4:50 p.m. Charlotte A. Smith‐Baker*1, Momoh Yakubu2, James H. Nance1, and Mahmoud A. Saleh1 1Texas Southern University, Department of Chemistry, Houston, TX 77004 2 Texas Southern University, Department of Pharmacy, Houston, TX 77004 Abstract 129


TECHNICAL ABSTRACTS Environmental toxicants such as pesticides pose a significant risk to human health. Pesticides are persistent organic compounds and are ubiquitous in our environment. They are used daily in our homes, work places, and school environments. They are found in air, water, soil, food sources, and biological materials. Pesticides are used extensively and are dispersed into the environment in great quantities. Therefore, analysis of pesticides as a biomarker is relevant and is needed for easy assessment of exposure. Analyses of pesticides in biological samples such as blood and urine have their limitations. They are invasive and non‐cumulative. Hair can accumulate pesticides and because of ease of sampling hair can be a good biomarker for analysis of pesticides and pesticide exposure. This study consists of developing an effective method for extracting pesticides from hair. Also, develop a sensitive method for the determination of pesticides in hair using gas chromatography with electron capture detector (GC‐ECD). This work was funded by RCMI Grant # R003045‐17 and NASA / TSU‐URC Grant # NCC9165. Technical Session 11 Thursday, p.m. 3:00 – 5:00 p.m. Aubert Organic Chemistry Session Chair Al fredWilliams, Ph.D. North Carolina Central University Presenters “Improving the physico‐chemical properties of anti‐cancer drugs via 3:00 p.m. – 3:15 co‐crystallization” p.m. Safiyyah Forbes, Christer B. Aakeröy*, and John Desper. Kansas State University, Department of Chemistry, Manhattan, KS 66502 Abstract Co‐crystallization has become an important method for improving the physico‐chemical properties (i.e. stability, solubility) of solid drug candidates. Crystal engineering is being used as a strategy for understanding and predicting hydrogen bonding interactions. The complementary pairing of two molecules held together by hydrogen bonding promotes the formation of a stable crystalline complex that contains both the active pharmaceutical ingredient (API) and the non‐toxic co‐crystallizing agent, Fig.1.

130


TECHNICAL ABSTRACTS Figure 1: Cocrystal of API and secondary co‐crystallizing agent held together via hydrogen bonding. Co‐crystallization synthesis of a family of anti‐tumor API’s was carried out using dicarboxylic acids generally regarded as safe by the FDA. Cocrystals were prepared in order to study the pharmacokinetic properties as well as the intermolecular interaction preferences between common binding sites in anti‐cancer drugs. From the studies conducted we were able to demonstrate a positive correlation between structural properties and physical properties of resulting pharmaceutical cocrystals. Therefore, it is possible to fine‐tune the thermal stability of API’s using cocrystals as new solid forms. “Fluoresence Of Corannulene Based Enediynes” 3:15 p.m. – 3:30 p.m. Teresa L. Cook, Derek Jones and James Mack* University of Cincinnati, Department of Chemistry, Cincinnati, OH 45221 Abstract The development of new organic materials is crucial to the development of nanotechnology. Corannulene, which is 1/3 of fullerene [60], potentially can be used as a building block to spearhead this development. Due to its unique fluorescent and electrochromatic properties, corannulene has the potential to advance organic light emitting diode (OLED) technology. We are in the process of synthesizing various corannulene based alkenes and linear acenes in order to cause a significant red shift in the absorbance spectra and increased luminescence of the molecules. To this end we have begun the synthesis of 2,3‐dibromoanthracene, cis‐1,6‐Bis(trimethylsiyl)hex‐3‐ene‐1,5‐ diyne and 6,13‐diethynylcoranulenylpentacene. We will report the synthesis and characterization of these molecules. 3:30 p.m. – 3:45 p.m.

“A Novel Approach To The Synthesis Of Silylated 1,3‐Alternate Calixarenes”

Prima R. Tatum, Paul F. Hudrlik, and Anne M. Hudrlik Department of Chemistry, Howard University, Washington, D. C. 20059, USA E‐mail: prima.tatum@gmail.com Abstract Silylated calixarenes are of potential interest in molecular recognition. Recently a number of C‐silylated cone calix[4]arenes [Me3Si, PhMe2Si, Ph2MeSi, (allyl)Me2Si] have been prepared in this research group. We are now investigating the synthesis of C‐silylated calixarenes in the 1,3‐alternate conformation. p‐tert‐Butylcalix[4]arene was dealkylated, and the 1,3‐alternate conformation was established via the two‐pot procedure of 131


TECHNICAL ABSTRACTS sequential treatment with propyl iodide/K2CO3 followed by propyl tosylate/CsCO3. The corresponding bromocalixarene was prepared using NBS. Silylation was carried out using the previous conditions via halogen‐metal exchange using tert‐BuLi, followed by silylating agents (Me3SiCl and PhMe2SiCl) giving the silylated 1,3‐alternate calixarenes. As before, a mixture of chlorosilane with triethylamine was used for the silylations. We are currently investigating novel ways to synthesize silylated compounds. We are studying the use of Grignard reagents to make the silylated compounds. We use the monocyclic compound bromoanisole as a template for the novel reactions before trying them on the calixarene. Although the monocyclic products are known, the methods in which they are synthesized are new. 3:45 p.m. – 4:00 p.m.

“Investigations Into Bacterial Communication Via Chemical Synthesis Of Autoinducer‐2 (Ai‐2)” Jacqueline A.I. Smith and Herman O. Sintim* Department of Chemistry and Biochemistry, University of Maryland, College Park, MD Abstract

Quorum sensing is a phenomenon which allows bacteria to coordinate processes such as virulence, antibiotic production and biofilm formation. Since biofilm is involved in 65% of infectious diseases, an effective way to inhibit quorum sensing is a good strategy to combat bacterial infections. Autoinducer‐2 (AI‐2) is a universal signaling molecule which exists in gram‐negative and gram‐positive bacteria. In enteric bacteria, a phosphorylated AI‐2 species plays a key role in the expression of quorum sensing‐controlled genes and undergoes a unique degradation process. The lack of a facile synthesis of AI‐2 has hampered the development of AI‐2 chemical probes required to investigate the E. coli system. We report a new synthesis of AI‐2 which provides access to a variety of analogues as well as phosphorylated AI‐2. We also show the effect of these analogues on biofilm formation in E. coli. 4:00 p.m. – 4:15 p.m.

“Reactivity Of A Cis‐Pd(II) Ar F Complex Towards Aryl C–F Bond Formation”

Nicholas D. Ball and Melanie S. Sanford* Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109 Abstract Direct carbon–fluorine reductive elimination from aryl PdII fluorides going through a PdII/Pd0 transformation has proven to be extremely challenging. Directed palladium‐ catalyzed oxidative fluorination of C–H bonds has been previously reported by our 132


TECHNICAL ABSTRACTS laboratory and has been proposed to proceed through an unusual Pd(II)/Pd(IV) mechanism. Key to the proposed mechanism is the existence of a monocyclometalled Pd(II) intermediate, which undergoes oxidative addition to a Pd(IV) species and subsequent reductive elimination. This presentation will discuss the synthesis of similar cyclometallated (L–L)PdII(p‐XPh)(F) complexes where X= CF3, F, OMe and L–L = t‐ BuBipy and their reactivity with stoichiometric quantities of electrophillic fluorinating agents. The reactivity of these complexes with XeF2 will demonstrate the viability of oxidative fluorination to create both electron rich and electron poor aryl fluorides in good yields. In addition, discussion of 19F NMR spectroscopy studies will highlight the reactivity of an isolated ‐aryl PdIV species towards C– F bond formation. These stoichiometric studies will emphasize the viability of Pd(II)/Pd(IV) C–F bond formation in catalytic systems. 4:15 p.m. – 4:30 p.m.

“A Free Radical Cyclization Approach To The Polyandranes”

Valerie C. Cwynar, Mathew G. Donahue, David J. Hart*, Grace K. Mbogo, and Dexi Yang Department of Chemistry, The Ohio State University, Columbus, OH 43210 Abstract This poster presents an approach to the synthesis of quassionoid natural products known as the polyandranes (3). The key reaction involves free radical cyclization of allenyl alcohol 1 to trans‐perhydroindan product 2. The poster will first present a synthesis of 1 via a reaction sequence that involves (a) Birch reduction of methyl 3‐methoxy‐5‐methylbenzoate, followed by alkylation of the intermediate enolate with iodomethyl pivalate, (b) reduction of the resulting diester with lithium aluminum hydride, (c) bromoetherification of the resulting diol followed by Swern oxidation of the resultant alcohol to give an aldehyde, and (d) reaction of the aldehyde with a propargyl titanium reagent to give 1. The synthesis of allenyl alcohol 1 will be followed by its conversion to trans‐perhydroindan 2 (along with some related model studies). Finally, plans for proceeding from 2 (or related compounds) towards the polyandranes (3) will be discussed. “Synthesis Of Some New Benzimidazole Carboxamides As Potential 4:30 p.m. – Anti‐Inflammatory Agents” 4:45 p.m. Laine Le,1 Lygheia Lewis,1 Kinfe K. Redda2and Bereket Mochona*1 1Department of Chemistry, 2College of Pharmacy and Pharmaceutical Sciences, Florida A&M University, Tallahassee, FL 32307 133


TECHNICAL ABSTRACTS Abstract Research efforts towards the discovery of cyclooxygenase‐2 (COX‐2) selective inhibitors has been made because of the potential therapeutic interest in inflammatory processes as well as in cancer proliferation, especially prostate and pancreatic cancer. In the course of research devoted to the development of new classes of anti‐inflammatory agents we have been interested in the modification of the well known nonselective COX‐2 inhibitors with benzimidazole moiety. The Benzimidazole moiety fulfils the minimum structural requirements that are common for anti‐inflammatory compounds. This is further confirmed by the conclusion that the derivatives of 1‐phenyl‐2‐styryl‐1H‐benzimidazole have been disclosed as anti‐inflammatory agents with COX‐2 inhibition. However, benzimidazole‐5‐caroxamides have not been studied towards anti‐inflammatory activity. Therefore, it was thought worthwhile to explore the anti‐inflammatory potential of carboxamide derivatives of 2‐hetero substituted benzimidazoles. The synthesis and characterization of 21 derivatives of benzimidazole carboxamides as potential anti‐ inflammatory agents will be presented. 4:45 p.m. – 5:00 p.m.

“Matrix Isolation Investigation Tetramethylethylene Ozonolysis”

Of

The

Mechanism

Of

Bridgett E. Coleman* and Bruce S. Ault Department of Chemistry, University of Cincinnati Cincinnati, OH 45221 Abstract The matrix isolation technique, combined with infrared spectroscopy and twin jet codeposition has been used to characterize intermediates formed during the ozonolysis of tetramethylethylene (TME). Literature and experimental spectral comparisons provide evidence for the formation of the primary ozonide (POZ) for this system while other possible intermediates include the secondary ozonide (SOZ) and the unobserved Criegee intermediate (CI). TMEPOZ absorptions observed in the twin jet experiments grew slightly upon annealing to 35K. These methods have previously identified formaldehyde and acetaldehyde as major products formed during the ozonolysis of propene merged jet (flow reactor) experiments. Likewise, merged jet experiments are expected to generate “late” stable oxidation products of TME. Identification of intermediates formed during the ozonolysis of TME is further supported by 18O isotopic labeling experiments and theoretical density functional calculations at the B3LYP/6‐311++G(d,2p) level.

134


TECHNICAL ABSTRACTS Thursday, p.m.

Technical Session 12 3:00 – 5:00 p.m. Parkview NOBCChE Professional Chemical Engineer Award Symposium Angela McIver, Ph.D. Department of Chemical Engineering, University of Iowa Presenters

Session Chair

3:00 p.m. – 3:45 p.m.

NOBCChE Professional Chemical Engineer Awardee “Calculations Of Wall Shear Stress In Left Coronary Artery For Pulsatile Flow Using Three‐Dimensional Computational Fluid Dynamics”

Sahid Smith, Shawn Austin and G. Dale Wesson* Department of Chemical Engineering, Florida A&M University, Tallahassee, FL Abstract The onset of coronary heart disease may be governed by distribution and magnitude of hemodynamic shear stress in the coronary arteries. This study numerically examines three‐dimensional pulsatile blood flow through the left coronary artery system. A triphasic waveform is employed to simulate pulsating flow. The Generalized Power law, non‐ Newtonian rheological model, is used to describe the viscous shear‐thinning behavior of blood. The results are reported in two separate sections of work. The first section contains results of the three‐dimensional simulation that includes curvature in the LAD and LCX. It is assumed that theses are the most realistic of the three flow domains studied. The second section presents the results of the two‐dimensional and three‐dimensional without curvature and compares them to those of the three‐dimensional with curvature. A major finding from the comparison of the results from the two‐dimensional predictions and the three‐dimensional predictions was: the WSSs predicted in this three‐dimensional investigation without curvature and the three‐dimensional investigation with curvature were greater than the WSSs predicted in the two‐dimensional investigation. A find from the comparison of the simulation with curvature and simulation without curvature was the predicted WSSs were greater in the simulation with curvature than the simulation without curvature.

135


TECHNICAL ABSTRACTS 3:45 p.m. – 4:10 p.m.

“Dendrimer‐Stabilized Fe2O3 Nanoparticles For The Growth Of Single‐Walled Carbon Nanotubes By Microwave Plasma CVD” Placidus B. Amama*, Timothy D. Sands, Timothy S. Fisher

Birck Nanotechnology Center, Purdue University, West Lafayette, IN 47907 Abstract Even though single‐walled carbon nanotubes (SWNTs) are known to possess outstanding material properties, their technological impact thus far has been low largely because of the difficulty associated with the control of their growth properties such as chirality, diameter, purity, and alignment. The growth of SWNTs via CVD offers one of the most attractive ways of controlling their properties because of the key role played by the catalytic nanoparticles. Although, the growth mechanism of SWNTs is still unclear, several studies have demonstrated the direct correlation between the nanoparticle size and the eventual diameter of the grown SWNT.[1] It is therefore necessary to precisely control the particle size distribution of the catalyst nanoparticles within the range selective for SWNT growth and to ensure the stabilization of these nanoparticles at high growth temperatures characteristic of CVD systems. In this work a fourth‐generation (G4) poly(amidoamine) (PAMAM) dendrimer (G4‐NH2) has been used as a “nanotemplate” to deliver nearly monodispersed catalyst nanoparticles to Si/SiO2, sapphire and porous anodic alumina (PAA) substrates. Fe2O3 nanoparticles obtained after mild calcination of the immobilized Fe3+/G4‐NH2 composite served as catalytic “seeds” for the growth of SWNTs by microwave plasma‐enhanced CVD (PECVD). The PECVD is suited to producing graphitized, vertically aligned high‐quality multi‐wall carbon nanotubes (MWNTs) and carbon nanofibers at low temperatures.[2] The growth of SWNTs by PECVD has proved to be difficult based on previous reports[3] and our experience mainly because it is difficult to maintain a low carbon supply in the PECVD growth environment. In order to surmount the difficulty associated with SWNT growth in the PECVD, reaction conditions that promote the stabilization of Fe nanoparticles, resulting in enhanced SWNT selectivity and quality, have been identified. In particular, in situ annealing of Fe catalyst supported on Si/SiO2, and sapphire in an N2 atmosphere was found to improve SWNT selectivity and quality as presented in figure 1. The SWNT selectivity and quality are indicated by the low frequency peak (radial breathing mode) occurring ~100‐350 cm‐1 and the integrated intensity of the G‐band relative to the D‐band, respectively. The application of DC bias voltage (+200 V) during SWNT growth was shown to be very effective in removing amorphous carbon impurities completely while enhancing graphitization, SWNT selectivity, and vertical alignment. The results of this study would 136


TECHNICAL ABSTRACTS promote the use of exposed Fe nanoparticles supported on different substrates for the growth of SWNTs, thereby utilizing some of the unique advantages offered by PECVD.[4] References: 1) Dai, H. J.; Rinzler, A. G.; Nikolaev, P.; Thess, A.; Colbert, D. T.; Smalley, R. E. Chem. Phys. Lett. 1996, 260, 471. (b) Sinnott, S. B.; Andrews, R.; Qian, D.; Rao, A. M.; Mao, Z.; Dickey, E. C.; Derbyshire, F. Chem. Phys. Lett. 1999, 315, 25. (c) Cheung C. L.; Kurtz, A.; Park, H.; Lieber, C. M. J. Phys Chem B 2002, 106, 2429. 2) Meyyappan, M.; Delzeit, L.; Cassell, A.; Hash, D. Plasma Sources Sci. Technol. 2003, 12, 205. 3) (a) Kato, T.; Jeong, G.; Hirata, T.; Hatakeyama, R.; Tohji, K.; Motomiya, K. Chem. Phys. Lett. 2003, 381, 422. (b) Kato, T.; Jeong, G.; Hirata, T.; Hatakeyama, R.; Tohji, K. Jpn. J. Appl. Phys. 2004, 43, L1278. (c) Li, Y.; Mann, D.; Rolandi, M.; Kim, W.; Ural, A.; Hung, S.; et al. Nano Lett. 2004, 4, 317. (d) Delzeit, L.; Nguyen, C. V.; Stevens, R. M.; Han, J.; Meyyappan, M. Nanotechnology 2002, 13, 280. 4) Amama, P. B.; Maschmann, M. R.; Sands, T. D.; Fisher, T. S. J. Phys. Chem. B 2006, 110, 10636.

4:10 p.m. – 4:30 p.m.

“Shear Flow In Entangled Polymers Investigated Using Confocal Microscopy And Particle Image Velocimetry”

Keesha A. Hayes*1, Mark R. Buckley2, Itai Cohen2 and Lynden A. Archer1 School of Chemical & Biomolecular Engineering, Cornell University, Ithaca, NY 14853 2Department of Physics, Cornell University, Ithaca, NY 14853

1

Abstract We use confocal microscopy and particle image velocimetry to visualize flow of entangled polymers in a custom‐built, planar‐Couette rheometer. Polybutadiene solutions spanning a range of molecular weights (Mw=200K, 788K) and entanglement densities (8 ≤ N/ Ne ≤ 56) are seeded with 250‐300 nm particle tracers. When compared to traditional couette and cone & plate geometries, our narrow gap (~ 35 μm), small aspect ratio (as < 1/143) shear cell is a more rigorous setting for exploring banding in entangled polymers. With increasing imposed shear rate, violations of the boundary no‐slip condition become more severe and the difference between the imposed and measured shear rates increases. Despite these observations, importantly, the measured velocity profiles are generally linear, even for rates in the non‐Newtonian shear regime. This finding disagrees with recent reports that shear banding is a characteristic flow response of entangled polymers, and instead points to interfacial slip as an important source of strain loss. The measured shear rates and shear stresses are used to characterize slip. We find two slip regimes; the transition to the highly non‐linear second regime occurs at stresses comparable to the elastic modulus of the entangled polymer network. These results are consistent both with polymer slip theories and published data obtained using other techniques. 137


TECHNICAL ABSTRACTS 4:30 p.m. – 5:00 p.m.

“Biocatalytic Systems for Aromatic Oxidations: The Production of Naphthalene Dihydrodiol” Angela M. McIver*, Tonya L. Peeples 1University of Iowa, Department of Chemical and Biochemical Engineering, Iowa City, IA 52242 Abstract

The purpose of this research is to engineer a biocatalytic system to facilitate the production of oxidation products in an economic and environmentally benign fashion. Oxygenases are powerful stereoselective and regioselective catalysts that are useful in the preparation of valuable pharmaceutical and specialty chemical intermediates. The need for cofactor regeneration necessitates the use of whole‐cells in such bioprocesses. We have selected to work with organisms carrying dioxygenases. Immobilization of these microorganisms will result in more stable biocatalysts that will be more amenable to meet process requirements. Specifically, retention of the immobilized catalyst will facilitate isolation of valuable products. This effort is critical to producing environmentally beneficial biotransformation systems by providing an environmentally benign oxidation process with reaction and separation of products. This work highlights some results comparing the effectiveness of naphthalene and toluene dioxygenases expressed in Escherichia coli for the oxidation of naphthalene to naphthalene dihydrodiol. The use of biphasic reaction media is used to increase productivity and enhance the reaction. The productivity is increased even more by using a small scale bioreactor. We will show methods of creating an environmentally benign system.

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POSTER ABSTRACTS NOBCChE Scientific Exchange Wednesday, p.m. Poster Session

Convention Center Hall 1

4:00 – 6:00 p.m.

Posters (ʺTitle,ʺ Presenter, Co‐Author(s), Affiliation)

“Studies of Bis(monoacylglycero)phosphate (BMP) Model Lipid Membranes Using Analytical Methods”

1

Janetricks N. Chebukati* and Gail E. Fanucci University of Florida, Department of Chemistry, Gainesville, Fl, 32611‐7200 Abstract Bis(monoacylglycero)phosphate (BMP) is an unusually shaped, negatively charged phospholipid found in elevated concentrations in the late endosomes. The unusual structure and stereochemistry of BMP are thought to play important roles in the endosome, including structural integrity, endosome maturation, and lipid/protein sorting and trafficking. We have utilized dynamic light scattering and transmission electron microscopy to characterize the morphology and size of BMP hydrated dispersions and extruded vesicles. We find that the morphology of hydrated BMP dispersions varies with pH, forming highly structured, clustered dispersions of 500 nm in size at neutral pH 7.4. However, at acidic pH 4.5, spontaneous hydrolysis of BMP occurs, altering the vesicle morphology to spherically shaped dispersions. BMP vesicles are also significantly smaller in diameter than phosphatidylcholine (POPC) and phosphatidylglycerol (POPG) vesicles. In a stability assay using dynamic light scattering measurements to compare and monitor 30 nm extruded vesicles of BMP, POPC, and POPG over a 5 week period, we find that BMP vesicles do not fuse to form larger structures. These results shed light on the possibility that the biosynthesis of BMP and the increasing acidity during the maturation process of late endosomes play an important role in the formation of intraendosomal vesicular bodies. 139


POSTER ABSTRACTS 2

“Synthesis and Characterization of Dual Property Magnetic Ionic Liquid Nanoparticles for Application in the Treatment of Various Forms of Cancer” Stacie LeSure Gregory Department of Chemistry, Louisiana State University Baton Rouge, LA 70803 sgrego1@lsu.edu Abstract Due to their unique physical properties and ability to function at the cellular and molecular level, magnetic nanoparticles (MNPs) have been explored for various biomedical applications including, contrasts agents for magnetic resonance imaging (MRI), local hyperthermia induction to selectively destroy cancer cells, and as magnetically targeted carrier systems in drug delivery applications. However, there is significant interest in recent years in developing MNPs having multifunctional characteristics with complementary roles. I am proposing the synthesis of MNPs utilizing room‐temperature ionic liquids (RTILs) that display superparamagnetic behavior, while simultaneously having the ability to fluoresce. Utilizing simple ionic exchange & taking advantage of their inherent tunability, I will synthesize a diverse array of ILs containing biocompatible fluorescent dyes as the cationic species and at the same time varying the anionic species, while maintaining magnetic properties. Upon the successful synthesis of dual property magnetic ILs, I will use a facile aerosol technique to fabricate MNPs. A variety of techniques, including UV‐Vis, Raman Spectroscopy, NMR, SEM, TEM and SQUID, will be utilized in an effort to fully characterize the properties of both the synthesized ILs and the magnetic nanooparticles. A proof of concept synthesis has already been completed for an IL containing a near IR dye as the cation and FeCl3 as the anion. Preliminary data supports the viability of the proposed work. These dual property MNPs will have a significant impact on the treatment of many forms of cancer. The supermagnetic property will allow these MNPs to be used as viable drug delivery systems, while the characteristic fluorescence will afford real‐time tracking of administered drugs. This research will take advantage of the unique physico‐chemical properties of RTILs coupled with the facile synthesis technique employed to fabricate low‐cost, environmentally friendly, and biocompatible MNPs. Due to the interdisciplinary nature of this work, it is anticipated that collaborations with faculty in engineering, physics and other areas of chemistry are highly probable.

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POSTER ABSTRACTS 3 “Use Of EDTA To Minimize Ionic Strength Frequency Shifting Effects In The 1H NMR Spectra Of Urine” Vincent Asiago, G. A. Nagana Gowda, Shucha Zhang, Narasimhamurthy Shanaiah, Jason Clark, and Daniel Raftery* Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN‐ 47905, USA Abstract The 1H NMR spectrum of urine exhibits a large number of detectable metabolites and is, therefore, highly suitable for the study of perturbations caused by disease, toxicity, nutrition or environmental factors in humans and animals. However, variations in the chemical shifts and intensities due to altered pH and ionic strength present a challenge in NMR‐based studies. With a view towards understanding and minimizing the effects of these variations, we have extensively studied the effects of ionic strength and pH on the chemical shifts of common urine metabolites and their possible reduction using EDTA (ethylenediaminetetraacetic acid). 1H NMR chemical shifts for alanine, citrate, creatinine, dimethylamine, glycine, histidine, hippurate, formate and the internal reference, TSP (trimethylsilylpropionic acid‐d4, sodium salt) obtained under different conditions were used to assess each effect individually. EDTA minimizes the frequency shifts of the metabolites that have a propensity for metal binding. Chelation of such metal ions is evident from the appearance of signals from EDTA complexed to divalent metal ions such as calcium and magnesium. Not surprisingly, increasing the buffer concentration or buffer volume also minimizes pH dependent frequency shifts. The combination of EDTA and an appropriate buffer effectively minimizes both pH dependent frequency shifts and ionic strength dependent intensity variations in urine NMR spectra.

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POSTER ABSTRACTS 4

“Synthesis And Complexation Properties Of Aza‐Crown Ether Containing Chromo‐ And Fluoroionophores” Shihab D. Deiab_, Edikan Archibong, Marsha Boatwright, Michael M. Lebel, Jason Caldwell, Nelly N. Mateeva* Department of Chemistry, Florida A&M University, 1530 M. L. King, Jr. Blvd., 219 Jones Hall, Tallahassee, FL 32307 Abstract Several novel chromo‐ and fluoroionophores incorporating aza‐18‐crown‐6, aza‐15‐ crown‐5 and diaza‐18‐crown‐6 ligands were synthesized utilizing modified published procedures and identified by 1H‐NMR and IR spectra. The compounds were purified by recrystallization and column chromatography. The chromophores are linked to the crown ethers via the nitrogen atoms which causes significant changes of the absorption and emission properties of the ligands upon complexation. In presence of metal ions (Na+, K+, Ca2+, Ba2+) as well as amino acids at different pH a hypsochromic shift was observed combined with a hypochromic effect. The complexation properties of these compounds were investigated by UV/Vis and fluorescence methods. A significant solvatochromic effect on the long‐wavelength charge transfer absorption was observed in solvents of different polarity. The latter provides information about the structure and geometry of the ground and excited state of the species. Upon addition of different analytes, fluorescence quenching or fluorescence enhancement was observed depending on the structure of the chromophore. The observed fluorescence and absorption changes were proportional to the concentration of the species.

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POSTER ABSTRACTS 5 “Epoxy Nanocomposites: Process Of Polymerization And The Effect Of Nanoclay Percent Loading On Thermal Properties” Abisola B. Ajayi*, Dr. Alvin P. Kennedy Morgan State University, Department of Chemistry, Baltimore MD 21251 Abstract The study of epoxy nanocomposites has acquired enormous attention in the recent years because it has been proved to make plastic materials suitable for different uses, such as automotive parts. The focus of this research is to monitor the polymerization process of epoxy nanocomposites in real time. The thermal properties of analysis include the Tg (the glass‐transition temperature) and polymerization exotherm. Materials used include the diglycidal ether of bisphenol A (DGEBA), the following curing agents, 4, 4‐ diaminodiphenylmethane (DDM), ortho‐Phenylenediamine (o‐ PDA), and nanoclay (I.28E). Cure properties are measured using the TA Instruments Q‐100 Modulated Differential Scanning Calorimeter (MDSC) and results are analyzed by TA Universal Analysis software. Only epoxy resin 828 was used to retain consistency with previous research, even though several others are known and available. Prepared samples contained stoichiometric ratios of epoxy resin to curing agent and 1, 3, and 5% loading of nanoclay in order to investigate differences in thermal properties. Thermosets were made prior to nanocomposites in order to better analyze the effect of nanoclay in the samples. My goal is to monitor the trend of the final Tg values in using o‐Phenylenediamine as the curing agent, instead of 4,4‐ diaminodiphenylmethane, which was used in previous research. Overall, we’ve discovered that the increase in percent loadings decreases the final glass transition temperature. This trend was observed with both DDM and o‐PDA. It was also observed that the highest final Tgs were obtained from DDM samples and nanocomposites.

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POSTER ABSTRACTS 6 “Dual Atomic Absorption And Atomic Fluorescence Measurments Of Mercury In Environmental And Biological Samples After A Single Combustion Event” Candice Tolbert and Dr. James Cizdziel* Department of Chemistry and BioChemistry, University of Mississippi, University, Ms 38677‐1848 Abstract Methylmercury (MeHg) is a neurotoxic compound that is produced in the environment by biotic and abiotic methylation of inorganic mercury (Hg); the species readily biomagnifies up the aquatic food chain. Because MeHg is almost completely absorbed into the gastrointestinal tract and transported throughout the body. Humans, particularly, unborn fetuses and young children are affected. Wildlife consuming fish are potentially affected, as well. Combustion‐atomic absorption spectrometry is a commercially available analytical technique that has been widely used to measure Hg in environmental and biological Samples, and the technique does not require sample pretreatment. Atomic fluorescence spectroscopy is inherently more sensitive and has a lower detection capability than atomic absorption spectrometry, however, combustion‐AFS is not commercially available, and to our knowledge there are not any reports in the literature evaluating the technique. In this study we will couple an instrument based on combustion‐AAS with an online AFS system. The system will be optimized and tested with standard reference materials. Figures of Merit will be established to compare the dual measurement techniques. It is expected that the AFS technique will yield lower detection limits which could open up the possibility of direct analysis of Hg in samples that are below the AAS detection limits, and that have previously required digestion followed by AFS.

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POSTER ABSTRACTS 7 “Application Of Ratiometric Spectral Properties Of Salicylidene Derivatives In The Analysis Of Selected Anions” Dharendra Thapa, Richard Williams*, and Yousuf Hijji Morgan State University, Department of Chemistry, 1700 E. Coldspring Lane, Baltimore, MD 21234 Abstract Intermolecular proton transfer in the ground and/or excited states contributes to changes in spectral properties that can be correlated to the intermolecular hydrogen bonding between the salicylidene derivatives and selected anions (fluoride, acetate, and phosphate) in an aprotic environment. The three derivatives of salicylidene family being investigated can be used as spectral probes to detect and quantitate the presence of anions on the degree of anion basicity. The absorbance and fluorescence properties were observed in the presence of varying concentrations of fluorine, acetate and phosphate anions in order to identify wavelengths that could effectively be utilized in the ratiometric analysis of selected anions. A plot of fluorescence intensity against anion concentration was used to obtain binding constants of derivatives with anions in acetonitrile. The absorbance ratiometric analysis for the three derivatives shows good correlation between their acidity and ability to complex with fluoride ions. The shift in the absorbance wavelength after addition of different concentrations of anions suggests the change in spectral properties of the derivatives. The fluorescence intensity of the derivatives increases as we increase the concentrations of anions added into it. The anion‐sensor hydrogen‐bonding complex is responsible for the change in spectral properties. Basicity of anions and intermolecular transfer play an important role in anion recognition. Fluorescence intensity and binding constants for anions correlate with the basicity of anions as they complex with derivative 1 and 3. Determination of fluorescence and binding constants of anions for derivative 2 is currently being investigated. Moreover, the absorbance ratiometric analysis for acetate and phosphate anions will be studied. Also, Job plot for varying concentrations of anions and the three derivatives is being done. The correlation of anion basicity in ratiometric analysis and fluorescence intensity provides evidence to support that these derivatives can be used as spectral probes for anion sensing and recognition. 145


POSTER ABSTRACTS 8

“An Investigation Of The Use Of Chitosan As A Substitute For 3‐(Amino‐ Propyl) Triethoxysilane (Aps) In The Fabrication Of Glass Surfaces For Use As Substrates In Metal Enhanced Fluorescence Techniques” Ichhuk Karki*, Richard Williams Morgan State University, Chemistry Department, Baltimore, Maryland, 21251 Abstract Metal Enhanced Fluorescence is a promising analytical technique that offers several advantages in overall detection sensitivity. The current preparation on glass surfaces calls for time consuming and corrosive colonization step before the application of APS as a precursor for the deposition of silver onto the glass substrate. APS is expensive and is harmful to environment. Therefore, this research is to investigate the use of chitosan as a substitute of APS in metal enhanced fluorescence techniques. Chitosan is a relatively inexpensive, friendly to environment, and readily available biopolymer which contains amino groups that allow it to form stable complexes with silver metal. The main aim of this research is to examine the Chitosan as a substitute for the silanization step and to deposit silver on the glass substrates, in order to investigate their potential use in the metal Enhanced Fluorescence techniques. The silver coated glass slides silanized with Chitosan and APS were compared. All absorption measurements were performed using UV‐vis spectrophotometer. The fluorescence of a glass slides coated with ICG‐HSA were measured using spectrofluorimeter. The glass slides silanized with chitosan had better metal enhanced fluorescence than others.

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POSTER ABSTRACTS “Investigation Of Ruthenium Complexes And Heptamethine Cyanine Near‐ Infrared Fluorophores As Donor/Acceptor Groups For Fluorescence Resonance Energy Transfer (FRET) Analysis”

9

Isha Pradhan*, Richard Williams Morgan State University, Chemistry Department, Baltimore, Maryland, 21251 Abstract There has been increasing interest in the use of infrared (IR) and near infrared (NIR) dyes as biological micro‐sensors due to their unique spectral characteristics. Two essential characteristics are the ability to minimize background interference from less useful biological components and the ability to exhibit optimal detection sensitivity and chemical stability. Fluorescence Resonance Energy Transfer (FRET) is an important technique for characterizing biological phenomena that are associated with changes in intermolecular distances. In this study, micelles were used to identify potential acceptor/donor pairs with luminescent properties in the far red and near infrared region of the visible spectrum for use in FRET analyses. A library of microwave synthesized heptamethine cyanine dyes were incorporated onto micellular surfaces along with Ru(bpy)32+ compounds (bpy = 2,2¢‐bipyridine). This mixture was excited at the maximum absorbance wavelength of the Ru(bpy)32+ compound and evidence for FRET was searched for at the fluorescence wavelengths of the near‐IR cyanine fluorophores. Time resolved lifetime measurements of the donor compound were obtained and used to calculate the Förster distance for acceptor compounds in the presence of the micelles. An immunoassay utilizing near‐ infrared cyanine fluorophores and the FRET phenomena was also developed. The results are reported.

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POSTER ABSTRACTS 10

“Antioxidant Potential Of Teas: Effect Of Adding Milk” Jennifer Brown_ and Nixon Mwebi* Jacksonville State University, Department of Physical & Earth Sciences, Jacksonville AL 36265 Abstract Apart from water, tea is the next most consumed beverage in the world. The beverage is generally made from the leaf and bud of the plant camellia sinessis. Depending on the processing technique the resulting product may be black tea (fermented), oolong tea (semi‐fermented) or green tea (non‐fermented). Studies have linked tea consumption with increased health benefits which is mainly attributed to the antioxidant potential of the various compounds such as polyphenols in the tea. In many parts of the world, tea is drunk with milk where the milk is added after brewing. In this case, whole milk, reduced percent milk, skimmed milk or powdered non dairy milk is used. Several studies have looked at the effect of adding milk on the antioxidant potential of tea; in a bid to safeguard and promote the healthful benefits of drinking tea. These studies have been inconclusive and differed widely; with some studies indicating that addition of milk has minimal or no effect on the antioxidant potential of tea; other studies indicate that milk addition enhances the antioxidant potential of tea, yet others argue that the milk addition inhibits the antioxidant potential of tea. This controversy forms the basis of this study which systematically addresses the effect of adding milk on black and green tea under the optimized conditions used in other studies. The study employs the FRAP technique which involves the reducing of the ferric complex to the ferrous complex by the reductant (antioxidant in the teas). Our results indicate that milk addition has an effect on the antioxidant potential of tea and the effect depends on several factors including the fat content of the milk added.

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POSTER ABSTRACTS 11

“Host‐Guest Chemistry Of Cyclodextrins And Labeled Drugs” Marsha Boatwright_, Edikan Archibong, Shihab D. Deiab, Jonny Williams, Nelly N. Mateeva* Department of Chemistry, Florida A&M University, Tallahassee, FL 32307 Abstract Cyclodextrins are popular hosts because of their ability to incorporate different species into their cavities. They are also good candidates for drug carriers due to the binding with biologically active substances. Cyclodextrins however, do not absorb in the visible area which complicates the detection of the complexation process. Labeling the guest molecules with appropriate chromophores is a convenient solution of this problem. The host‐guest chemistry of the interaction between cyclodextrins and chromophore‐linked drugs was investigated using UV/Vis and fluorescence methods. The non‐binding interactions with the cyclodextrins changes the spectral properties of the chromophore included in the cavity. The spectral changes indicate the strength and the type of the interactions taking place in the complexation process. A significant blue shift of the charge‐transfer complex of the chromophore was observed indicating the interruption of the donor‐acceptor interaction in the host molecule.

12

“Chitosan‐Assisted Synthesis Of Silver Nanoparticles By Electrodeposition” Melissa A Pinard, Yongchao Zhang* Morgan State University, Chemistry Department, Baltimore, MD, 21251 Abstract In this study silver nanoparticles were prepared by electrodeposition in the presence of chitosan, a polysaccharide polymer with glucosamine as its building block. Indium tin oxide (ITO) coated glass was used as the base electrode. The ITO electrode was inserted in 0.1 M KNO3 solutions containing different concentrations of AgNO3 and chitosan, and a potential of ‐0.1 V (vs. Ag/AgCl) was applied. Ag+ ions were reduced and Ag nanoparticles deposited on the electrode surface. It was found that chitosan regulated the size of the Ag particles and prevented further aggregation of the Ag particles; with chitosan, Ag particles with diameters of several hundred nanometers were found uniformly distributed on the electrode surface, while in the absence of chitosan Ag clusters on the order of microns were found. Further investigations in regard to the control of the size of the nanoparticles and nanoparticle‐ enhanced fluorescence are underway.

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POSTER ABSTRACTS 13

“High Density Fluidic Network With Integrated Embedded Waveguide For High Throughput Screening: Application In Drug Discovery” Paul I. Okagbare*1, Jost Gottert4, Proyag Datta4 and Steven A. Soper1,2,3 Department of Chemistry1, Department of Mechanical Engineering2, Center for BioModular Multi‐Scale Systems3, and Center for Advanced Microstructures and Devices4 Louisiana State University, Baton Rouge, Louisiana Abstract High Throughput Screening (HTS) of elements from combinatorial libraries represents the first step in the drug discovery pipeline. Microfluidics is a viable platform for performing HTS due to its ability to automate fluid handling and generate fluidic networks with high numbers of processors over small footprints appropriate for optical imaging. Unfortunately, few efforts have been invested into developing microfluidic platforms to generate high information content systems appropriate for HTS. While most HTS campaigns depend on fluorescence, readers typically use point detection and serially address the assay results, significantly lowering throughput. To address these challenges, we present here the fabrication of high density microfluidic vias packed into the imaging area of a large field‐of‐view (FoV) ultrasensitive fluorescence detection system. Two different fluidic architectures were evaluated for providing an optical system with single molecule sensitivity, (1) High density fluidic network using epi‐illumination interrogation with beam shaping optics to provide a wide FoV. The fluidic channels are 1 μm (width and depth) with a pitch of 1 μm. A 40X objective (numerical aperture = 0.75) creates a FoV of 200 μm providing the ability to interrogate ~100 vias. A charge couple device (CCD) operated in a frame transfer mode is used for tracking fluorescent molecules as they pass through the irradiating field. (2) Embedded waveguide situated orthogonal to the fluidic vias, which defines the excitation volume. Fluorescence sampling is accomplished using an evanescent field with extremely shallow channels to keep the sampling efficiency high (~60% for 500 nm deep channels) due to the small penetration depth (~300 nm) of the evanescent field. The fluidic structures were fabricated using UV‐LIGA to produce Ni electroforms. Embossing of the structures was accomplished with a JenOptik HEX02 high‐ precision hot embossing system to create high fidelity in the features over large areas. The utility of these multichannel networks for HTS with an optical system for producing the prerequisite sensitivity was demonstrated by performing high throughput single molecule fluorescence detection with epi‐illumination. Single fluorescent dyes (AlexaFluor 660) were identified using a test high density fluidic device (5 μm x 1 μm; pitch = 5 μm) fabricated in PMMA. The fluidic system for HTS will be evaluated by screening potential therapeutic agents for AP‐Endonuclease (APE1), a target that generates a strand break in DNA and has been linked to radio‐ and chemo‐resistance in human tumors. KEYWORDS: HTS, Microfluidics, CCD and Ultrasensitive Detection 150


POSTER ABSTRACTS 14

“Electrodeposited Chitosan/Silver Nano Particle Composites Improve The Sensitivity Of An Enzyme Based Phenol Sensor” Yanique Thomas, Yongchao Zhang* Morgan State University, Chemistry Department, Baltimore, MD, 21251 Abstract Amperometric biosensors for phenols were fabricated by (1) electrodepositing Ag nano particles on a glassy carbon electrode together with the bio‐polymer chitosan, (2) followed by subsequent immobilization of mushroom tyrosinase in the chitosan/Ag NP matrix. It was found that the presence of chitosan regulated the electrodeposition of Ag NP from Ag+ in the solution, prevented the aggregation of the Ag particles, and led to uniform distribution of Ag NP of ~500 nm. Immobilized tyrosinase catalyzed the oxidation of phenols to o‐quinones which were then directly reduced at the electrode to catechols, which were then oxidized to o‐quinones again by the enzyme, thus regenerating the redox active species, o‐quinones. The cycling of phenols (and catechols) to o‐quinones and back to catechols provided an amplified electroreduction current which was used to quantify the phenols. Compared with sensors made without Ag NP the sensitivity was improved ca. 25‐fold. Supported by NSF HRD‐0627276.

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POSTER ABSTRACTS “Plasmon Resonance Behavior Of N‐Homocysteinylated Gold Nanobioconjugates” Christina M. Jones1, Isiah M. Warner*1, Arther T. Gates1,

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James W. Robinson1, Robert M. Strongin2 1Department of Chemistry and College of Basic Sciences, Louisiana State University, Baton Rouge, Louisiana 70803 2Department of Chemistry, Portland State University, Portland, Oregon 97207 Abstract Recent reports suggest that homocysteine thiolactone (HTL) may be pathogenic because it can readily modify proteins, a process known as N‐homocysteinylation, to yield protein homocystamide (N‐Hcy‐protein), an emergent biomarker for cardiovascular disease. For this reason, the development of rapid and direct detection methods for this emergent protein biomarker is of interest. Our laboratory has recently demonstrated the use of plasmon resonant gold nanoparticles (GNPs) for N‐Hcy‐protein detection. In this work, we further investigate the underlying physicochemical processes that mediate the plasmon resonance behavior of GNPs in the presence of N‐Hcy‐protein using gold nanobioconjugates prepared from cytochrome c, human serum albumin, and human serum proteins. Citrate‐capped GNPs were synthesized and incubated with the desired protein solution in order to produce GNPs with physically adsorbed protein‐passivation layers. Each gold nanobioconjugate was evaluated to determine its respective susceptibilities to N‐homocysteinylation. Time course dynamic light scattering (DLS) spectroscopy studies were conducted in order to monitor the growth of modification‐directed nanoparticle assemblies. UV‐vis spectroscopy was also employed to monitor the effect of N‐homocysteinylation on SPR bands of the gold nanobioconjugates. Interestingly, our data suggest that modification‐induced denaturation of protein on the surfaces of the GNPs may contribute to the nanoparticle assembly process. The DLS studies indicate that the modification‐directed nanoparticle assemblies form and remain associated. Modification‐directed assembly growth approached 300, 70, and 135nm for cytochrome c, human serum albumin, and human serum gold nanobioconjugates, respectively. Corresponding trends in the SPR band intensity were observed in visible absorption studies. This work provides valuable mechanistic insight that is immediately applicable to our efforts to develop a sensor for cardiovascular disease screening.

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POSTER ABSTRACTS 16 17

“Aza‐Crown Ether Containing Spectrophotometric Reagents For Complexation With Hg(II) Ions” Edikan Archibong_, Shihab D. Deiab, Marsha Boatwright, Michael M. Lebel, Mercedes Jackson, Nelly N. Mateeva* Department of Chemistry, Florida A&M University, 1530 M. L. King, Jr. Blvd., 219 Jones Hall, Tallahassee, FL 32307 Abstract Several novel compounds containing aza‐18‐crown‐6, aza‐15‐crown‐5 and diaza‐18‐crown‐ 6 were synthesized and their complexation ability toward Hg(II) was investigated. The compounds were obtained via modified published procedures and their structure was confirmed by proton NMR and IR spectra. The ligands contain appropriate links connected via the nitrogen atom which provide additional binding sites and also serve as a chromophore thus enabling the spectrophotometric and spectrofluorimetric determination of the complexes. The complexation was initially studied in acetonitrile and the process was investigated by the absorption and emission changes. In addition extraction studies were performed where the mercury salts were dissolved in water, the pH was adjusted using an acetate buffer and the complexes were extracted in chloroform. The method allows for reliable determination of micromolar amounts of mercury. “Synthesis Of Porphyrin‐Peptide Conjugates With Affinity For Epidermal Growth Factor Receptor” Alecia M. McCall, M. Graca H. Vicente* Louisiana State University, Department of Chemistry, Baton Rouge, LA, 70803 Abstract The early diagnosis of aggressive cancerous growths is still a difficult challenge. It is pertinent, then, to develop new methods for early cancer detection. Colon cancer is one such malignancy that is being studied extensively. New methods for in vivo imaging have been proven to be successful in uncovering colorectal tumors. In this study, peptide derivatives of meso‐tetraphenylporphyrin were designed and synthesized with structural features that can potentially make them selective for Epidermal Growth Factor Receptor (EGFR), as it is known that EGFR is overexpressed in colorectal cancers. The porphyrin‐ peptide conjugates are highly fluorescent and therefore will assist in delineating colorectal cancers via fluorescence‐based techniques. The conformation of these porphyrin conjugates have been investigated using Gaussian 03 software; previous research suggests that porphyrin‐peptide conjugates bearing a 20‐atom PEG‐based linker prefer an extended, over a contracted conformation, which might favor EGFR binding. We will discuss the design and synthesis of new porphyrin‐peptide conjugates, their characterization and biological investigation. Our results have impact in the design of new molecules to be used for in vivo imaging. 153


POSTER ABSTRACTS 18 19

“Dynamics Of Repression By Native And Pre‐Assembled Cro Dimers In Living Bacteria” Jacqueline J. Harris, Michael C. Mossing* Department of Chemistry and Biochemistry, The University of Mississippi, Oxford, MS 38677 Abstract Upon induction of a gene several events (transcription, translation, protein folding, multimer assembly) take place before the induced gene is expressed. The speeds of each step will have an effect on the rate of gene expression. Cro repressor is a dimer, which helps regulate the master switch of lambda phage development. Its assembly is slow in vitro (in a test tube). We would like to know whether the rate of assembly is similar in vivo (in living cells). We have constructed simplified control circuits, which contain either no Cro gene (OPO), a wtCro gene (CRO), or a single‐chain Cro gene (scCRO) to measure the effects of dimer assembly on the dynamics of repression. In these circuits a promoter under the dual control of lac and lambda operators drives expression of Cro in tandem with the lac Z reporter gene. Upon addition of IPTG, lac repression is released and Cro starts to accumulate along with β‐galactosidase (β‐gal). As Cro, folds, assembles and binds to the lambda operator lac Z will again be subject to repression. The time course and steady state expression levels of lac Z have been monitored as a function of the Cro gene included in the circuit. Our goal is to fit in vivo lac Z expression profiles to a set of ordinary differential equations and compare them to in vitro data. “A Study Of The Self‐Assembly Of Water‐Soluble Porphyrins In Aqueous Solution” Javoris V. Hollingsworth, Paul Russo and M. Graca. H. Vicente* Louisiana State University, Department of Chemistry, Baton Rouge, LA 70803 Abstract In nature, self‐assembly processes of biologically active organic molecules often occur, resulting in the formation of dimers and higher oligomers of various and sometimes complex structures. This natural occurrence of self‐organization has been subject of research, with the aim to understand and possibly modulate the aggregation behavior of biological molecules. The meso‐tetrakis(4‐phosphonatophenyl)‐porphyrin, H2TPPP was synthesized, purified, characterized, and its self‐assembly was studied in aqueous solutions as a function of pH and time. The variations on the max and shape of the Soret band of this porphyrin in the absorption spectra when altering the pH indicated the pH‐ dependency in the hierarchical self‐assembly of H2TPPP in aqueous solution. Time dependency of the aggregation is also examined and reported. 154


POSTER ABSTRACTS 20

“Testing A Model: Ca2+ Induced Exposure Of Tryptophan” Chinelo Udemgba, Nagamani Vunnam, Yogini Bhavsar and Dr. Susan Pedigo* Department of Chemistry and Biochemistry, University of Mississippi, University, MS 38677‐1848 Abstract Cadherins are transmembrane cell adhesion proteins that are critical for tissue formation and maintenance. Cell adhesion by cadherin requires binding of 3 calcium ions at the interfaces between the ectodomain modules. Recent data suggest a model in which calcium induces a relatively large conformational change in the first ectodomain module, domain 1, by causing the detachment of the ƒʺA‐strand from the core of domain 1 and the exposure of a tryptophan in the second position, W2. The exposure of W2 is crucial for formation of a strand‐crossover structure that is believed to be the adhesive dimer interface. In order to establish direct experimental evidence for this model, a construct of Neural‐cadherin comprised of the first two ectodomain modules, NCAD12, and its single tryptophan mutants, W2A and W113A, were examined. While the W113A mutation did not affect the stability of the protein, the W2A mutation dramatically increased the stability of the protein. The calcium‐dependent characteristics of the proteins were analyzed separately with fluorescence spectroscopy and size exclusion chromatography. Regardless of the calcium level in solution, W2A was monomeric. W113A behaved like the wild type protein in that calcium allowed exchange between the monomer and dimer. We envisioned that a red shift in the fluorescence signal would confirm exposure of W2. In contrast to the model above, there was no observable shift in the fluorescence signal. It is possible that the ʺopenʺ conformation, in which W2 is exposed, is transient and difficult to monitor. We are currently exploring the kinetics of the fluorescence signal change.

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POSTER ABSTRACTS “Spontaneous Rhythmic Contraction Of The Urinary Bladder”

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Joseph Mburu3, Vikram Sabarwal1, Corey Johnson2, Adam Klausner2, Paul Ratz1* 1Departments of Biochemistry and Pediatrics, and 2Department of Surgery/Division of Urology, Virginia Commonwealth University, Richmond, VA, and 3Department of Biochemistry, North Carolina State University, Raleigh, NC Abstract Purpose: The objective of this study was to determine whether isolated strips of detrusor smooth muscle (DSM) of the urinary bladder produce prostaglandins (PGs) responsible for spontaneous rhythmic contractions (SRC). Introduction: PGs are endogenous signaling molecules and have been suggested to cause SRC in the DSM of the bladder. PGs are produced by the transformation of arachidonic acid into PGs by cyclooxygenase (COX). We recently determined that bladder interstitial cells of Cajal (ICC) express COX. The clinical relevance is that elevated SRC in the human bladder is associated with a disorder referred to as overactive bladder. Method: Longitudinal strips of the detrusor smooth muscle (DSM) free from underlying urothelium were dissected from rabbit bladder and either incubated in a physiological salt solution (PSS) for 1, 5 and 15 minutes with or without (control) the non‐ selective COX inhibitor, ibuprofen (IBU) 30 μM, the selective COX 1 inhibitor, SC‐560 (0.1 μM), and the selective COX 2 inhibitor, NS‐398 (0.1 μM), to measure PG production using EIA, or attached to an isometric force transducer to measure the ability of the COX inhibitors to attenuate SRC. Results: EIA analysis showed that strips of DSM in PSS produced 0.55 ρg/mg/min PGs, and that both selective COX inhibitors (NS 398 and SC 560) reduced PG production to 0.31 ρg/mg/ min PGs and 0.27 ρg/mg/min PGs, respectively. The non selective COX inhibitor, IBU, also reduced PGs production (0.26 ρg /mg / min PGs).The force experiment showed that SRC was decreased by all 3 COX inhibitors. Conclusion: Our data showed that PGs were produced by strips of bladder free from urothelium, and that PGs were responsible for SRC. Enhanced SRC in human bladder is associated with symptoms of overactive bladder, a disorder that affects many people as they age. These results could be a step forward in discovering rational therapies that will target the overactive bladder.

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“Constructing A Reporter Vector For Evaluating Synthetic RNA Elements Regulating Eukaryotic Translation In Vitro” 1Kofi Atta‐Boateng_, 2Stephen J. Goldfless, 2Jacquin C. Niles* 1Albany State University, Albany, GA 31705, 2Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139 Abstract Despite significant advances in understanding the mechanisms regulating eukaryotic translation, more research is needed to effectively utilize this knowledge for controlling translation in biological systems. Our objective is to construct a luciferase reporter vector for evaluating synthetic RNA elements regulating eukaryotic translation in vitro. We amplified Renilla reniformis luciferase gene by PCR and cloned it into pET24(a)+ vector. Next, we inserted an aptamer cloning site into the intermediate construct, transformed and confirmed it with electrophoresis and colony PCR. Results show that we have successfully amplified the Renilla reniformis luciferase gene and cloned it into the pET24(a)+ vector. Additionally, we have succeeded in cloning a linker region that simultaneously facilitates: (i) insertion of DNA sequence encoding specific RNA aptamers upstream of the luciferase gene; and (ii) transcription of the putatively aptamer‐regulated luciferase mRNA by the T7 RNA polymerase. Next, we will insert one control oligonucleotide and two test aptamers into our reporter construct, after which we can proceed with in vitro transcription and capping to yield the reporter mRNA needed for in vitro translation studies. The presence and absence of aptamer‐binding protein and the distance between the cap and the aptamer will be studied to give information on their effect on translation. “Nutritional Mechanisms That Promote A Healthy Circulatory System” Harbour MA, Caldwell JE Michigan State University, East Lansing, MI Abstract Epidemiological evidence has established that ingestion of Omega‐3 fatty acids, has a profound effect on combating many cardiovascular diseases (CVD). Here we investigated on a molecular level, the effects of omega‐3 acids, docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) on CVD’s. Data is reported from two different dietary studies that incorporated different sources and amounts of EPA and DHA in post Myocardial Infarction (MI) patients diet. In both studies these patients were followed for at least two years following their MI. The patients that ingested larger doses of EPA and DHA showed a trend of decreased recurring MI’s and less cardiovascular incidents than those including small amounts or none at all in their diet. EPA has been shown to directly inhibit two key enzymes that are responsible for the synthesis of very low density lipoprotein (VLDL). 157


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“Characterization Of Active Transporter Systems At Blood‐Brain Barrier” Shanika N. Smith*, Johnmesha L. Sanders, Antonie H. Rice, PhD. University of Arkansas at Pine Bluff, Chemistry, Pine Bluff, AR 71601. Abstract The delivery of therapeutic drugs to the brain continues to be a challenge for the pharmaceutical industry. The blood‐brain barrier (BBB) regulates the influx and efflux of a wide variety of substances, and remains the major obstacle in the delivery of drugs to the central nervous system (CNS). Various strategies have been devised to circumvent the BBB in order to increase drug delivery to CNS. The purpose of this work was to assess the potential mechanistic pathways present at the Blood‐brain barrier in bovine microvessel endothelial cells (BBMECs). The following transporters were characterized in the BBMEC cell culture system: a) the monocarboxylic acid transporter (MCT), b) the organic anion transporter (OAT), and the c) Na+dependent dicarboxylate transporter (NADC). Western Blot analysis was employed to demonstrate the presence of each transporter. These transporters were characterized by assessing the uptake and permeability properties of known substrates. To assess the functionality of each transporter uptake experiments were performed in the presence/absence of known metabolic inhibitors of the transporters. Competitive uptake and permeability experiments were also performed for each. The experiments demonstrate that all of the transporters are present and actively functional in the BBMEC system. These transporters offer alternative routes for delivering therapeutics to the brain that may exhibit poor brain/CNS bioavailability.

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“Anisomycin – Indueed Jnk Activation Via The Ribosomal Interaction” Dara Phillips, Hee Kyong Bae, and James Pestka* Michigan State University, Department of Food Science and Human Nutrition, East Lansing, MI 48825 Abstract ‘Trichothecene mycotoxins are a family of toxic sesquiterpenoids produced by foodborne and environmental fungi that are of concern to human and animal health. Trichothecenes rapidly diffuse through the cell membrane, bind to the eukaryotic ribosomes, and inhibit translation by interacting with peptidyl transferase. Additionally, trichothecenes activate mitogen‐activated protein kinases (MAPKs), which are mediated signaling cascades that drive critical cellular processes such as gene expression, differentiation, mitosis, and apoptosis’ (Bae and Pestka 2008). Ribotoxic stress response is a phrase coined for the mechanism by which translation inhibitors such as trichothecenes, induce phosphorylation of MAPKs such as p38, c‐Jun N‐terminal kinases (JNKs), and exxtracellular signal‐ regulated kinases (ERKs). Thus, this study will focus on the anisomycin‐induced ribotoxic stress response, specifically as it relates to JNK phosphorylation, in order to test the hypothesis that the ribosome acts as a common sensor for Strepomyces (a natural compound in anisomycin that is common in the environment). Analytical data has yet to be collected for the stated hypothesis due to the recent beginnings of experimentation and previous focus on Deoxynivalenol (DON)‐induced ribotoxic stress. “Preparation Of 5‐Aryl Pyrazole ‐3‐ Carboxylates For Ligand And Sphingosine Kinase Inhibitor Syntheses” Demetrius Miles and Christian Grattan* Winthrop University Abstract An investigation into the synthesis of 5‐arylpyrazole‐3‐carboxylates has been initiated. Multiple applications for pyrazole chemistry, including ligand and novel sphingosine kinase inhibitor synthesis, have been investigated and developed to examine the bioorganic impact of these novel structures. Tris(pyrazolyl)methane and bis(pyrazolyl)methane ligands, shown below, were originally developed by Trofimenko as the neutral, isoelectonic analogues to tris(pyrazolyl)borates and bis(pyrazolyl)borates. Although the borate ligands have been extensively studied, the methane derivatives have received much less attention, partly because of their synthetic challenges. Since these pathways have been improved, interest has rapidly expanded. These methane ligands are now widely used in nanomolecular polymers and metalloprotein studies.

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POSTER ABSTRACTS 26 Another bioorganic application for these pyrazole compounds involves the synthesis of new sphingosine kinase‐1 inhibitors. By reducting the carboxylate group to an alcohol, we have developed a new area for synthetic modification within our lead compound structure. Subsequent oxidation to form the aldehyde, will allow for a more thorough study of how these derivatives will interact and ultimately impact the inhibition of sphingosine kinase enzyme. Future work includes refining the synthesis for all reactions, converting the pyrazole alcohols to pyrazole aldehydes, and coming up with additional derivatives for the sphingosine kinase‐1 inhibitors for collaborative testing. The project described was supported by NIH Grant Number P20 RR‐16461 from the National Center for Research Resources for support of the program entitled ʺSouth Carolina IDeA Networks of Biomedical Research Excellence (SC‐INBRE) and by a NSF Research Initiation Grant Number MCB05‐5810542242 to TFS. 27

“Hollow Fiber Filtration Of Hemoglobin” Frederick Smalls and Andre Crawford* Ohio State University, Columbus, OH

Abstract Blood transfusions have been helpful for a lot of people because it helped to restore much needed oxygen derived from hemoglobin found in red blood cells. Hemoglobin purification methods came about because hemoglobin forms a basis to red blood cell alternatives = st1 ns = ʺisiresearchsoft‐com/cwywʺ />(Hemoglobin‐Based Oxygen Carriers).Chromatography is the most common method used but it is known for autoxidizing the hemoglobin samples. As a result, Tangential Flow Filtration is a newer method that is used to purify hemoglobin through multistage hollow fibers and a filtration pump. Diafiltration is a method that accompanies tangential flow filtration because it helps to get rid of impurities in the third stage retentate. After the stages of hemoglobin purification are complete the impurities, protein concentration, methemoglobin percentage and oxygen affinity is tested. The purified samples maintained the properties needed for hemoglobin purification.

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POSTER ABSTRACTS “Reusable Solid Rocket Motor Ballistics: Low Level Tail‐Off Analysis” Leethaniel Brumfield, III* and Stanley Tieman NASA, George C Marshall Space Flight Center, Redstone Arsenal Propulsion Systems Dept, ER 50 Building 4205, Huntsville, AL 35812 Abstract

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Tail‐off, the earliest time to the latest action time, was defined for the newly designed 06907 reusable solid rocket motor (RSRM) model as 20 seconds of motor operation after the time the motor reached 50 psia measured head‐end pressure. Low pressure tail‐off thrust model enveloped solid rocket booster (SRB) performance from thrust tail‐off through separation from the shuttle to ensure no contact would occur. RSRM ballistics was performed to analyze whether the flight operation pressure from the 06907 model was comparable to that of the new five segment RSRMV. An adjusted RSRM shape term was used to calculate low level σ tail‐off traces. The RSRM shape term scaled during the first 1.4 seconds to match the dispersion peak times for the RSRMV dispersions, which suggests that the new shape term allows for more variation than the trace projects. Low pressure SRM/HPM data appropriate for RSRM characterization was performed, which proved that mean and variation of low pressure data for RSRMV was very similar to RSRM. In addition, burn rate was calculated as 0.368 in/sec nominal, ± 0.005 in/sec variations, while propellant mean bulk temperature (PMBT) variation ranged from 50‐82 ºF. Uncertainty equaled 1% on thrust and scale factor uncertainty was 2.6% on thrust, which were both the same as the loads equation. Low level tail‐off data cut off at ~7 seconds after 50 psi and there was no data beyond this point. The upper 3‐σ limit after cut‐off was extrapolated from last value and followed similar shape to RSRM. In conclusion, flight operation pressure from the 06907 model was 4486 lbf/psia (versus 4088 for RSRM) and the updated performance nominal and dispersed values corresponded to the RSRMV. *To whom correspondence should be addressed: Telephone: 405.269.6868; Mail: 601 S Washington Street #293, Stillwater, Oklahoma 74074; E‐Mail: leleethaniel@yhaoo.com

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POSTER ABSTRACTS 29 “Protection Against Chemically –Potentiated Liver Injury Is Detected By Cyanine Fluorescence” Evelyne Ntam1, Tricia Charles1, Roxanne Howell1, Michael Baker1, Dwayne Hill*1. 1Department of Biology, Morgan State University, Baltimore MD 21251. Abstract Retinoids are essential for the normal homeostasis of tissues and organ systems. Retinoids can also be used in the therapeutic treatment of certain adverse health conditions including dermatological alterations, visual anomalies and selected cancers. Conversely, retinol has been shown to potentiate the hepatotoxicity compounds including bromotrichloromethane (BrCCL3), galactosamine and carbon tetrachloride (CCL4). Bromotrichloromethane is an industrial degreasing agent and can undergo toxic potentiation that produces severe hepatotoxicity. The mechanism(s) of this potentiation is not completely understood. Studies have suggested that retinol potentiation of liver injury may involve increased activation of hepatic macrophages (Kupffer Cells). Polyphenolic flavinoids have been shown to reduce macrophage activity, inhibit inflammatory response and protect against liver injury. In addition, the application of cyanine fluorescence may be useful in analyzing flavinoid activity. Therefore, the current study was designed to test the hypothesis that pretreatment with polyphenolic flavinoids can alter the ability of retinol to potentiate bromotrichloromethane‐induced liver injury by increasing kupffer cell activity. In addition, the study will determine if fluorescent cyanines can verify the protective effects of the flavinoids. Male Sprague Dawley rats were treated with 50mg/kg of polyphenolic flavinoid for seven days prior to the potentiation of hepatotoxicity using 75mg/kg of retinol and 100‐200mg/kg of bromotrichloromethane. The markers of hepatotoxicity included aminotransferase (AST), alanine aminotransferase (ALT), and gamma glutamyltranspeptidase (GGT) levels. An increase in plasma levels and activity of the markers were indicative for liver injury. This study demonstrated a significant elevation of AST, ALT and GGT activity levels in the plasma of rats treated with retinol and BrCCL4. Pretreatment with silymarin protected against the elevations of plasma markers of hepatotoxicity. The reduction of kupffer cell activity also decreased the plasma levels of hepatotoxicity markers. In addition, fluorescent cyanines verified the protective effects of the flavinoids. (DOE Grant ER63580)

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“Synthesis And Characterization Of Bimetallic Zintl Clusters” Domonique O. Downing* and Bryan W. Eichhorn University of Maryland, Department of Chemistry and Biochemistry, College Park, MD 20742 Abstract The synthesis and characterization of bimetallic Zintl clusters with main group and transition metal atoms has been of particular interest to the growing field of nanotechnology. Nanotechnology is driving much of current technology advances and is already impacting the everyday lives of nearly everyone. Nanomaterials are at the core of advances in electronic technology, information storage, optical biosensors, and drug delivery vehicles to name a few. Despite their importance, much is still unknown about the structure, stability, and dynamic properties of small nanoparticles; especially containing two or more elements. The synthesis, characterization, and applications of very large bimetallic nanoclusters may address these critical issues. Studies in this area can lead to an understanding of how big nanoclusters or small nanoparticles behave in applications such as heterogeneous catalytic reforming in the oil and gas industry, fuel cell electrocatalysis, or advancements in high temperature superconductors. Cluster anions Sn9Ir(cod)3‐, Pb9Ir(cod)3‐, and Rh2H(PPh2)2(PPh3)31‐ have been synthesized and characterized. The former two are the first known examples of Sn‐Ir and Pb‐Ir bimetallics and may provide new insight into structure and bonding of these bimetallic systems. All complexes have been studied via X‐ray crystallography and nuclear magnetic resonance spectroscopy. This work involves moving to the next level of bare cluster anions, which serves an important role of relating gas phase clusters to those in the solid state. New binary clusters which will lead to the next generational size of nanoclusters are to be targeted.

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“Ruthenium Polypyridine Bisthioethers For Use As Pdt Agents” Robert N. Garner and Claudia Turro* The Ohio State University, Department of Chemistry, 100 W 18th Ave. Columbus, OH 43210 Abstract [Ru(bpy)2(L)]2+ (bpy = 2,2’‐bipyridine; L = 1,2‐bis(phenylthio)ethane, 3,6‐dithiaoctane, eythlenediamine, and 1,2‐dianilinoethane) complexes were synthesized to study their ligand loss photochemistry for potential use as photodynamic therapy (PDT) agents. Computational studies of the complexes examined excited state bond distances and showed a greater elongation of the Ru‐L bonds for complexes containing bisthioether as compared to bidentate nitrogens. These studies also showed the sulfur containing complexes have low‐lying dd states, that have been implicated in ligand loss. Photolysis experiments show that the bisthioether ligands are easily photosubtituted by Cl‐, bpy, and H2O. In addition, these complexes show photoinduced binding to nucleic acids and DNA. The same activity is not observed in the nitrogen complexes. The ability of sulfur complexes to undergo photoinduced ligand loss will aid in the ability to use monoclonal antibodies to direct the PDT agents to cancerous cells.

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“Synthesis Of High Free Volume Acid For Proton Conducting Electrolytes” LaRico Treadwell and Dr. Jason Ritchie * Department of Chemistry and BioChemistry, University of Mississippi, University, Ms 38677‐1848 Abstract Proton conducting electrolytes composed of mixture of MePPG3BzSO3H acids in a polymer MePEG7 were prepared with two different concentrations of the acid. The solutions displayed anhydrous proton conductivity at 55 degrees Celsius. The acidity of the acid (MePPG3BzSO3H) was measured to be 98%. The percent of the final product was calculated to be 92%. The conductivity measured for MePPG3BzSO3H was 1.51x10‐ 5(s/cm) at low concentration of the acid and 1.74 x10‐6(s/cm) at the high concentration of the acid

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POSTER ABSTRACTS “Electronic Conductive Polymers With Biospecific Binding Capacities: New Materials For Nanoscale Biosensors” 1 Reuven Darkeyah*, 1 Sannigrahi Biswajit, 1 Khan Ishrat*, 2 Sil Dwaipayan, 2 Baird Barbara*

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1Department of Chemistry, Clark Atlanta University Atlanta GA 30314, USA 2Department of Chemistry and Chemical Biology, Cornell University Ithaca, NY 14853, USA Abstract A series of DNP (2,4‐dinitrophenyl)functionalized polypyrrole polymers that are specific to antibodies and immune receptors on cell have been synthesized and characterized (See Figure). This is a terpolymer composed of three monomers; monomer 1 (M1, pyrrole), macromonomer 2 (M2, pyrrole with pendant ethylene glycol) and macromonomer 3 (M3, pyrrole with pendant DNP). These polymers are expected to be useful for controlling receptor binding and cell activation, and with eventual application in biosensors. Conductivity measurement indicate that the terpolymers are conductive, without adding external doping agents conductivity values of 5 x 10‐6 S cm‐1 (at 25 oC) were obtained. Binding studies with anti‐DNP IgE studies are promising, fraction of binding sites occupied vs. concentration indicates specific and efficient binding at nanomolar concentration. Therefore, DNP functionalized polypyrrole are excellent materials for preparing nanowires in biosensors for detecting biomarkers. We have also determined that these polymers are biocompatible. Nanowires are currently being fabricated using the functionalized conductive polymers. In addition to synthesis and characterization, the thermal properties of the functional polymers will be discussed with regards to the fabrication of nanowires for biosensing applications.

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“Quantum Electronic Stability In Noncovalent Functionalization Of Carbon Nanotubes” Olayinka O. Ogunro† and Xiao‐Qian Wang‡* Clark Atlanta University, Department of Chemistry†, Department of Physics‡, Center for Functional Nanoscale Materials*, Atlanta, GA 30314‐4391 Abstract Noncovalent interactions are at the heart of many biological processes that nature utilizes to from complex structures. The success with which we can predict how an assembly of molecules spontaneously adheres to homogenous surfaces depends on our ability to mimic this process, both experimentally and theoretically. Single‐walled carbon nanotubes (SWNTs) produced from laser ablation and chemical vapor deposition techniques aggregate into bundles held by van der Waals forces. These interactions have hindered separation methodologies that aim to produce chiral specific carbon nanotubes, from a broad diameter based sample distribution. The selectivity of SWNT by free‐base porphyrin has been demonstrated to remove semiconducting nanotubes from a mixture containing the later in addition to metallic nanotubes. This technique affords poor yields of semiconducting SWNTs. An improvement on this is the chiral selectivity of (8,6) tube with an efficiency of 85%. With the help of molecular dynamics and first‐principles calculations we investigate this interaction in various molecular assemblies that spontaneously self‐assemble onto the sidewalls of single‐walled carbon nanotubes.

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“Evaluating How The Slight Modification Of A Donor GROUP Substitutient Effects Electron Transfer Efficiency In Paraphenylene Dimmers” Jeremy Lipscomb and Darlene K. Taylor* Department of Chemistry, North Carolina Central University, Durham, NC 27707 Abstract Is there a way to make a more efficient solar energy conversion device? The answer is intimately connected to scientists’ ability to design the next generation of materials that are energy efficient transfer agents, robust, and economically viable. Polymers are one of many materials being extensively investigated. The first experiments will concentrate on the effects of altering the donor groups attached as a side chain to paraphenylene dimer model compounds followed by . Results on the synthesis and classification of three dimers will be presented. Gaussian B3LYP calculations will be presented to show that the band gap decreases within the dimer series as a function of the donor group efficiency. Presentation of our most recent results on the electrochemical and optical properties of the dimers will be included. The results from this study should enable us to better understand donor group effects on electron transfer in substituted paraphenylenes and ultimately lead to the design of novel materials for solar energy conversion devices. “The Effects Of Temperature On A Cross Linked Hyperbranched Polyglycerol‐Drug Conjugate” Melony A. Ochieng and Darlene K. Taylor * Department of Chemistry, 3179 MT Science Complex, North Carolina Central University Durham, N.C. 27707 Abstract The efficacy of drugs can be greatly improved by delivering the drug to the target site with minimal systemic exposure. Broad degrees of enhanced and targeted drug delivery vectors are now possible due to the significant advancement in polymer chemistry which has made hyperbranced polymers an attractive drug delivery vehicle. This project focuses on developing a temperature sensitive linker to assist in the delivery of drugs to cancerous breast tissue cells. We will present our most recent results on the development of this temperature sensitive linker and its conjugation to the hyperbranched polyglycerol platform.

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POSTER ABSTRACTS “Synthesis Of Thiophene Monomers Using The Grignard Reaction”

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Stephen MaffettI, Robin LaskowskiII, Malika Jeffries‐ELII* ILouisiana State University, Baton Rouge, LA 70803 IIIowa State University, Ames, IA 50011 Abstract Since the discovery of conductivity in polyacetylene over 30 years ago, conjugated or conductive polymers have been explored for use as organic semiconductors. The advantages that conjugated materials possess over conventional inorganic semi‐ conducting and conducting materials include ease of fabrication and the ability to modify the electronic properties of the material through chemical synthesis. Of all conducting polymers, thiophene polymers are among the most widely studied as a result of their environmental stability and high conductivity. Regioregular poly(3‐alkylthiophene)s (rr‐ P3ATs) are among the most widely studied conducting polymers. It has also been established that modification of monomers’ chemical structure is a useful approach toward tuning the polymers properties. Affordable and efficient synthesis of thiophene monomers is a step toward making conducting polymers marketable. Our goal is to synthesize monomers based on 2‐2’‐bithiophene (2‐BT, a step in the synthesis of novel monomer) and 3‐hexylthiophene (3‐HT, a common monomer) efficiently. Using a Ni(dppp)Cl2 catalyzed cross‐coupling method between 3‐ bromothiophene and Grignard reagents derived from alkyl halides or a Ni(dppp)Cl2 catalyzed cross‐coupling between 2‐bromothiophene and its Grignard reagents we produced good yields of 3‐HT and 2‐BT, respectively. 38

“Mechanistic Studies Of Gold(I)‐Catalyzed Intramolecular Hydroamination And Hydroalkoxylation With Allenes” Alethea N. Duncan* & Ross A. Widenhoefer Duke University, Chemistry Department, Durham, NC 27708 Abstract Kinetic studies and deuterium labeled experiments were completed to determine the mechanism of gold(I)‐catalyzed intramolecular hydroamination and hydroalkoxylation of 1,2‐butadiene (1) with benzyl carbamate (2) and 1‐phenyl‐1‐propanol (3). The proposed mechanism involves generation of the active catalyst Au(NHC)+ followed by reversible coordination to 1 to form a gold ‐allene complex. Subsequent nucleophilic attack of 2 or 3 on the activated olefin is followed by proton transfer by the NH2 or OH group to the unsaturated carbon. Protonolysis of the Au—C bond releases the N‐allylic carbamate or alkyl allylic ether and regenerates the cationic Au(I) catalyst. 168


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“Synthesis Of Novel Diruthenium Coupled Nucleobase Complexes” Darryl Anthony Boyd*, Tong Ren Department of Chemistry, Purdue University 560 Oval Dr, West Lafayette, IN, 47907 Abstract The synthesis and characterization of transition metal complexes that are coupled to nucleobases is a burgeoning area of research. It has been well established that metal complexes, such as cis‐platin, can be very beneficial in disease prevention. Recently, it has been shown that dinuclear complexes can likewise have therapeutic benefits.1, 2 In the work presented here, two routes to synthesizing biologically relevant dinuclear complexes will be explored using diruthenium paddlewheel complexes. The first method uses the Sonogashira coupling method to couple the diruthenium complex Ru2(D(3,5‐ Cl2Ph)F)3)(DMBA‐4‐C2TMS)Cl to 5‐iodouracil.3‐7 The second method takes advantage of the discovery that some common chelating ligands, such as bipyridine, can mimic the chelating effect seen with nucleos(t)ides.1, 2, 8 Bipyridine will serve as a chelating ligand to the diruthenium complex Ru2(D(3,5‐Cl2Ph)F)2)(OAc)2Cl. The ultimate goal(s) of this work is to explore the possibility that single‐nucleotide polymorphisms (SnPs) can be detected using nucleotide‐bound diruthenium complexes. An alternative goal is to determine if nucleotide‐bound and/or ligand‐bound diruthenium complexes can serve as viral inhibitors and/or DNA intercalators.2, 8 References: (1) Chifotides, H. T.; Catalan, K. V.; Dunbar, K. R., Inorganic Chemistry 2003, 42, 8739. (2) Chifotides, H. T.; Dunbar, K. R., Accounts of Chemical Research 2005, 38, 146. (3) Ren, T., Organometallics 2005, 24, 4854. (4) Robins, M. J.; Barr, P. J., Journal of Organic Chemistry 1983, 48, 1854. (5) Chen, W. Z.; Ren, T., Inorganic Chemistry 2006, 45, 8156. (6) Rose, E., Organometallics 2007, 26, 5727. (7) Seela, F.; Sirivolu, V. R.; Chittepu, P., Bioconjugate Chemistry 2008, 19, 211. (8) Chifotides, H.; Dunbar, K. R., Biochemistry 2003, 42, 8606.

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POSTER ABSTRACTS “Studies On The Synthesis Of Spiroisoxazolines”

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Erick D. Ellis, and Ashton T. Hamme II* Department of Chemistry, College of Science, Engineering and Technology, Jackson State University, 1400 Lynch Street, P.O. Box 17910, Jackson, Mississippi, USA Abstract A series of natural products isolated from the sponge of Verongida have been intensively studied due to the presence of alkaloids with one, or more bromotyrosine residues. Many of these alkaloid metabolites show interesting bioactivity and cytotoxic properties in tumor cell lines. 11‐Deoxyfistularin‐3 is cytotoxic against human breast carcinoma cell line MCF‐ 7. Many of these bromotyrosine natural products possess the spiroisoxazoline moiety. The purpose of this project was to find a synthetic methodology towards the synthesis of the spiroisoxazoline ring core. The synthesis of the 4,5‐dihydroisoxazole precursor to an analogue of 11‐deoxyfistularin‐3 was accomplished by using 1,3‐dipolar cycloaddition with a functionalized alkene. The synthesis of 4‐methylene‐5‐oxo‐hexanoic acid ethyl ester was accomplished through the addition of 4‐acetyl‐5‐oxo‐hexanoic acid ethyl ester, 30% aqueous formaldehyde and aqueous potassium carbonate. The cycloaddition of 4‐ methylene‐5‐oxo‐hexanoic acid ethyl ester with phenyl hydroximoyl chloride using triethylamine in dichloromethane and heat afforded only the 5,5 disubstituted 4,5‐ dihydroisoxazole regioisomer. The synthesis of the spiroisoxazoline, 8‐methoxy‐3‐phenyl‐ 1‐oxa‐2‐aza‐spiro[4.5]deca‐2,7‐dien‐6‐one, was accomplished through the intramolecular cyclization and methylation of the isoxazoline precursor, 5‐acetyl‐3‐phenyl‐4,5‐dihydro‐ isoxazol‐5‐yl‐propionic acid ethyl ester. In order to improve and accelerate our process of forming the spiroisoxazoline, 4‐acetyl‐5‐oxo‐hexanoic acid ethyl ester, 30% aqueous formaldehyde and aqueous potassium carbonate were used to form 5‐acetyl‐3‐phenyl‐4,5‐ dihydro‐isoxazol‐5‐yl‐propionic acid ethyl ester. Next, the 1,3‐dipolar cycloadditon of 5‐ acetyl‐3‐phenyl‐4,5‐dihydro‐isoxazol‐5‐yl‐propionic acid ethyl ester with the analogous nitrile oxide formed 5‐acetyl‐3‐phenyl‐4,5‐dihydro‐isoxazol‐5‐yl‐propionic acid ethyl ester. Finally, 8‐methoxy‐3‐phenyl‐1‐5‐acetyl‐3‐phenyl‐4,5‐dihydro‐isoxazol‐5‐yl‐propionic acid ethyl ester oxa‐2‐aza‐spiro[4.5]deca‐2,7‐dien‐6‐one was synthesized by intramolecular cyclization, and methylation of 5‐acetyl‐3‐phenyl‐4,5‐dihydro‐isoxazol‐5‐yl‐propionic acid ethyl ester. Key words: 11‐Deoxyfistularin‐3, Breast Cancer, and Natural Products. Acknowledgments: This research was financially supported by: NSF‐RISE HRD‐0734645, NIH‐SCORE Grant Award Number 2S06GMOO7672‐29, and the NIH‐RCMI supported NMR Core Laboratory.

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POSTER ABSTRACTS “Self Assembly Of Halogenated Polycyclic Aromatic Carboxylic Acids”

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Josette Crout Seibles* Department of Chemistry, Rutgers University, Piscataway, NJ ABSTRACT While formation of aromatic carboxylic acid dimers by carboxyl‐to‐carboxyl hydrogen bonding is a well‐studied and much reported phenomenon for benzoic acid and other monocyclic aromatic carboxylic acids, the formation of analogous polycyclic aromatic carboxylic acid dimers by hydrogen bonding has received scant attention in the chemical literature. Polycyclic aromatic carboxylic acid dimers have been reported for 9‐anthracene carboxylic acid, 2‐anthracene carboxylic acid, 6‐methoxy‐2‐anthracene carboxylic acid and 9‐acridine carboxylic acid. The author (jcs) has observed the formation of carboxylic acid dimers for 10‐chloro‐9‐anthracene carboxylic acid in dilute chloroform‐methanol solution (10‐5 M) at room temperature using UV‐visible spectroscopy. In a strong hydrogen bonding solvent such as 100% methanol the carboxylic acid is hydrogen bonded to the solvent and dimer formation is suppressed. The addition of chloroform, however, favors the formation of the dimer. The structure of the dimer is such that the plane of the anthracene rings is orthogonal to the plane of the six hydrogen‐bonded atoms. This ring dimer structure is the same as that reported for the parent compound 9‐anthracene carboxylic acid. The mechanism of formation of this dimer involves the very slow rotation of the anthracene rings and/or plane of the six hydrogen bonded atoms around the essential single bond joining the two. Steric strain due to the peri hydrogens is the driving force for rotation to orthogonal dimers and aggregates. Peri hydrogen steric strain is well known in anthracene derivatives. This rotation results in a decolorization of 10‐chloro‐9‐ anthracene carboxylic acid due to the uncoupling of the carbonyl pi system from the aromatic ring pi system. Higher even‐numbered aggregates such as the tetramer, hexamer and octamer are also formed either via halogen bonding with the chlorine in the 10 position to form linear arrays or via π‐π stacking to form multiple decker sandwiches or via a combination of halogen bonding and π stacking. The ring dimer is the repeating unit. Higher aggregates of anthracene itself at 77 K have been alluded to in the literature. However, the tetracarboxylic acid, hexacarboxylic acid and octacarboxylic acid are novel aggregates not previously reported. Halogen bonding and π stacking are both relatively weak noncovalent bonding. These types of weak noncovalent bonding and the stronger O—H · · ·O hydrogen bonding are important in molecular recognition such as occurs in the formation of biological structures and biological aggregates and in biological processes. The four isosbestic points in the UV spectrum of 10‐chloro‐9‐anthracene carboxylic acid in methanol‐chloroform represent monomer to dimer, dimer to tetramer, tetramer to hexamer and hexamer to octamer equilibria. Preliminary fluorescence and low temperature HPLC data support the presence of multiple species.

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“Synthesis Of Novel Epoxy Gemini Surfactants From Vernonia Oil” Nikki S. Johnson*, Folahan O. Ayorinde Howard University, Department of Chemistry, Washington, DC, 20059 Abstract Vernonia galamensis is a new potential industrial oilseed crop found in Africa. It is the source of a naturally epoxidized oil called vernonia oil (VO) which is extracted from the seed of the plant. It is this epoxy functionality that makes vernonia oil unique in comparison to all other vegetable oils such as coconut oil, palm kernel oil, soybean oil, sunflower oil, etc., of which none contain the level of epoxy acid found in VO. Generally, vegetable oils, which are biorenewable resources, are good starting materials for surfactants, which are surface active molecules containing both hydrophobic and hydrophilic groups. They are used as wetting agents because they lower surface tension and interfacial tension. Surfactants can be found in paints, fabric softeners, dyes, cosmetics, and detergents as well as many other materials. In these applications surfactants aid in lubrication, catalysis, tertiary oil recovery, drug delivery, etc. Classically, there are four main types of surfactants: anionic, cationic, nonionic, and zwitterionic. However, a new type of surfactant, called gemini surfactants, has recently evolved. Gemini surfactants have shown superior surface activity in comparison to the others. For this reason, we have chosen these surfactants to be the focus of our research. The purpose of my research is to synthesize surfactants more specifically gemini surfactants, from vernonia oil, that are more efficient and economical in their applications. “Selective, Stoichiometric Ligand‐Enabled Oxidation Of Sp2 And Sp3 C‐H Bonds Via Palladacycles With Hydrogen Peroxide” Williamson Oloo, N. Zhang, Vedernikov Jing, and N. Andrei Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland Abstract The use of environmentally friendly oxidants dioxygen (air) and hydrogen peroxide is of great practical importance. Selective, stoichiometric ligand‐enabled oxidation of various palladacyclic complexes with C(sp2)‐Pd, and C(sp3)‐Pd bonds was performed at room temperature using hydrogen peroxide as a mild oxidant. The oxidation is only possible when chelating pyridine‐derived ligands: di(2‐pyridyl)methanesulfonate (dpms), and di(2‐ pyridyl)ketone (dpk) are used. Solvents can also be involved in these Pd‐C bond functionalization reactions leading to products with various C‐X bonds (X= OH, OMe, and OAc). 172


POSTER ABSTRACTS “Synthesis Of Spiro‐Isoxazolines Via Intramolecular Cyclization” Brittny C. Davis, Ann O. Omollo, Eric McClendon, Lungile Sitole, and Ashton T. Hamme II* Department of Chemistry, College of Science, Engineering and Technology, Jackson State University, 1400 Lynch Street, P.O. Box 17910, Jackson, MS, 39217, USA Abstract

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Psammaplysins A‐E are a family of natural products that were isolated from marine sponges of the order Verongida. Many of these natural products display antiviral and antineoplastic activities. The most interesting structural motifs of the psammaplysins are the oxipin and isoxazoline ring systems which are connected in a spirocyclic array. The synthesis of this type of ring system was accomplished in two steps. These synthetic processes involve a 1,3‐dipolar cycloaddition and an intramolecular ring closure of a pendant alkoxide or carboxylate ion onto an activated isoxazole. The 1,3‐dipolar cycloaddition of an alkyne with a nitrile oxide from the analogous alpha‐ chlorobenzaldoxime afforded the desired isoxazole. Intramolecular cyclization was achieved through the reaction of the isoxazole ring with pyridinium tribromide. The proposed mechanism of intramolecular cyclization involves the activation of the isoxazoline ring with bromine to form a bromonium ion. Neighboring group participation of the oxygen can cause an opening of the bromonium ion intermediate thereby giving rise to an oxonium ion. Intramolecular attack of the alkoxide or carboxylate ion onto the oxonium ring system then affords the spiro‐isoxoline. More specific information pertaining to the synthesis, mechanistic details, and isolated yields for the synthesis of our spiro‐isoxoline compounds will be discussed. Key words: Spiro‐isoxazolines, Cycloaddition, Regioselectivity, and Heterocycles. Acknowledgments: This research was financially supported by: NSF‐RISE HRD‐0734645, NIH‐MARC Grant Award Number 5T34GMOO7672‐29, NIH‐SCORE Grant Award Number 2S06GMOO8047‐35, and the NIH‐RCMI supported NMR Core Laboratory. “Progress Towards The Development of Potential Pathogen Biosensor” 45 Charlee K. McLean*, Dr. Angela Winstead* Department of Chemistry, Morgan State University, Baltimore, MD Abstract Near infrared (NIR) cyanine dyes have been used over the years in various biological applications, such as, fluorescence labeling probe. Unsymmetric cyanine‐5 (Cy‐5) dyes 173


POSTER ABSTRACTS have been used over the years as biosensor for the detection of smallpox and various other pathogens. The Cy‐5 dyes exhibits emission spectra between the regions of 670‐710 nm. This is a problem as biological molecules, such as, heme and other molecules like visible fluoro probes also fluoresce in this same region. The objective of this research is to synthesize NIR dyes that will be used to detect smallpox, using a more efficient method; a dye that will fluoresce at a longer wavelength than the Cy‐5 dyes. Initial studies have been done towards optimizing the synthesis of various heptamethine dyes; in an efficient time using Microwave Assisted Synthesis. The heterocyclic salt, bisimine, and sodium acetate and minimal ethanol are combined in a vial and subjected to microwave radiation. The five NIR symmetric dyes: ethyl dye, methyl dye, propyl dye, carboxylic dye and alcohol dye, have been synthesized with percentage yield of 79.0, 70.5, 81.0, 83.5, and 64.5 respectively. The dyes fluoresce between the regions of 780‐790nm. The analysis of the H1 NMR concludes that the dyes have been successfully synthesized. The NIR‐dyes are significantly pure compared to dyes synthesized using previous methods. The synthesis of the ethyl‐hexanoic unsymmetric dye used in the detection of smallpox, using MAOS has been synthesized with a percentage yield of 78.8. The conversion of the carboxylic acid to the active NHS ester to the ethyl‐hexanoic dye is currently under investigation. 46

“Microwave Assisted Conversion Of Aldoximes To Nitriles” Chidi Anyanwutaku, Dr. Yousef Hijji*, Morgan State University, Department of Chemistry, Baltimore, MD 21251 Abstract Nitriles are useful precursors for the synthesis of amines, amides, amidines, ketones, carboxylic acids, esters, and a host of other compounds. They have wide applications in industries such as textile and other industries. Preparation of nitriles from the corresponding aldehydes is therefore, a highly valued reaction because of the versatility of nitriles. The aim of this project is efficiently synthesize nitriles in one step under the microwave. A typical synthetic method will first be used in which an aldehyde will be converted to an oxime using hydroxylamine Hydrochloride. The oxime then forms a nitrile after dehydration. Following the typical approach, the nitrile will be synthesized directly in one step under the microwave using the aldoxime. Temperature and time will then be evaluated to determine the optimal conditions to produce the highest yield.

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POSTER ABSTRACTS “Approaches Toward The Atroposelective Synthesis Of Chiral Polyaryls” Donovan Thompson, Alan McDonald, and Dr. Karelle Aiken* Chemistry, Georgia Southern University, Statesboro, GA 30460 ABSTRACT

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Approaches toward the atroposelective synthesis of chiral polyaryl compounds using “Lactone Concept” (LC) methodology will be reported. The LC approach was developed by Dr. Gerhard Bringmann and colleagues for the atroposelective synthesis of biologically active, chiral biaryls. Potential applications for the chiral polyaryl targets in this study involve use of the compounds (i) as glycomimetic inhibitors of enzymes and (ii) as ligands or, chiral auxiliaries in asymmetric reactions. The LC synthesis of a model triaryl lactone will be reported: 48

“A Simple Highly Efficient Method For The Synthesis Of Nitriles” Emmanuel Dowuona, Dr. Yousef Hijji* Morgan State University, Department of Chemistry, Baltimore, MD 21251 Abstract Nitrile chemistry has become a very crucial aspect to organic synthesis. Because of their unusual properties, nitriles serve as synthetic intermediates for pharmaceuticals, agricultural chemicals, and even dyes. They can be converted to ketones, carboxylic acids, amines, esters, and amides, and their polarity makes them ideal aprotic solvents. This project is aimed at converting methyl aldoximes to nitriles under microwave conditions. By changing the temperature and time of heating, the conditions and yields will be optimized. The compatibility of the conditions will be evaluated by using aromatic, aliphatic, and conjugated aldehydes and compounds with sensitive groups as alkenes. The mechanism and reaction conditions will be discussed. 175


POSTER ABSTRACTS 49

“Understanding Why The Strongest Halide Binding Occurs With The Weakest Hydrogen Bond Donors In Triazolophanes” Esther O. Uduehi, Yuran Hua, Kevin P. McDonald, Jonathan A. Karty and Amar H. Flood* Chemistry Department, Indiana University, 800 East Kirkwood Avenue, Bloomington, IN, 47405 Abstract Triazolophanes are a family of shape‐persistent macrocyclic compounds that are known to bind anions solely through C–H hydrogen bond donors. A number of triazolophanes have been studied previously and their high binding affinities (K > 106 M–1) were attributed to

the high degree of pre‐organization of eight traditionally‐weak hydrogen bond donors. In this work, a series of triazolophanes incorporating propylene linkages, instead of phenylenes, were synthesized and characterized to further investigate pre‐organization. The rigidity of the macrocycle is weakened with the introduction of flexible propylene(s), and the triazolophanes therefore show reduced binding affinities. Compared to a rigid triazolophane 1, the binding constants with chloride are decreased by two and four orders of magnitude in 2 and 3, respectively. This study, as a negative control of pre‐organization, helps to elucidate the anion binding nature of shape‐persistent macrocycles. “Microwave Assisted Synthesis Of Non‐Symmetric Near‐Infrared Dyes” 50 Jamiece E. Johnson*, Dr. Angela Winstead* Department of Chemistry, Morgan State University, Baltimore, MD, 21251 Abstract Near Infrared dyes are important sensitizers, from their strong spectral properties in the longer wavelength region with minimal background from biomolecules and high sensitivity. Heptamethine cyanine dyes are useful as fluorescent tags in DNA sequencing, immunoassay and flow cytometry. Non‐symmetrical dyes are important when changes in the spectral and physical properties of the dyes are preferred when using specific applications and compatibility with instrumentation. Our approach uses microwave assisted organic synthesis to synthesize non‐symmetric dyes with faster times, comparable yields and without toxic solvents. The first step is to combine one equivalent of Salt A, sodium acetate, bisimine and ethanol in a microwave vial, in a radiator for 15 min. at 100ºC. After cooling to room temperature, Salt B and sodium acetate is added to the vial for an additional 15 minutes at 100º C. The synthesized cyanine dyes have been successfully synthesized and in good yields. Current investigation involving benzenethiazol salt derived cyanine dyes. 176


POSTER ABSTRACTS 51

“Synthesis And Photophysical Characterisation Of Hepthamethine Cyanine Dyes” Stanley N. Oyaghire*, Dr. Angela Winstead*, Dr. Richard Williams* Department of Chemistry, Morgan State University, Baltimore, MD 21251 Abstract Heptamethine cyanine dyes are currently used as fluorescence labels and sensors of biomolecules in vivo because their spectra reach into the near infrared (NIR) region, where auto fluorescence by a biological matrix least occurs. However, a major disadvantage of these dyes is that their Stokes shifts are small (less than 25nm). The Stokes shift, which determines the fluorescence of the emitted photon, has to be large in order for the detector to identify the fluorescence signal from background noise. Also other spectral properties such as quantum yield, detection sensitivity, and molar absorptivity are important factors in fluorescence studies of these dyes. Ten symmetric and non‐symmetric hepthamethine cyanine dyes have been synthesized in our lab by Microwave Assisted Organic Synthesis, which involves heating heterocyclic salts, bisimine and sodium acetate in a single‐mode microwave. Spectral studies have been conducted on these dyes and properties such as Stokes shift, quantum yield, molar absorptivity, and detection sensitivity have been determined. Studies on these dyes reveal an increase in molar absorptivity and a decrease in quantum yield for the non‐symmetric alkyl substituted cyanine dyes from the symmetric dyes. Current work involves determining the effect of structure modifications of the dyes on their observed spectral properties. Modifications include substitution of the chlorine atom on the central reactive site of the dye with amine groups and hydrogen and changing the counter ion to determine their effects on the spectral properties. The synthesis of the amine substituted dyes is still under investigation.

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“Characterization Of Model Systems For The Development Of A Single Molecule Trap” Dominique A. Brooks, Christine A. Carlson, Jorg C. Woehl* Department of Chemistry and Biochemistry University of Wisconsin‐Milwaukee Milwaukee, WI 53201 Abstract Optical trapping of objects with nanoscale dimensions has evolved tremendously since its first inception in 1970. It is not yet possible, however, to use optical tweezers to trap single molecules without attachment to micrometer‐sized polystyrene beads. We are developing 177


POSTER ABSTRACTS a new system to trap and manipulate single molecules on surfaces using near‐field scanning optical microscopy probes. Our current focus is on the preparation of model systems that show movement in two dimensions, such as the diffusion of organic molecules which have been inserted into lipid films. Some questions we are addressing are: How does film deposition pressure affect the velocity of single molecule diffusion, and how does the number of layers affect the number of diffusing molecules? This insight will be crucial for the preparation of two‐dimensional systems suitable for trapping experiments. “Substituent Effects On The Energetics Of Trans To Cis Isomerization In 53 Cyclohexene” Jeffrey D. Veals* and Dr. Steven R. Davis Department of Chemistry and BioChemistry, University of Mississippi, University, Ms 38677‐1848 Abstract Renewable Energy Sources are becoming increasingly important. Many are looking for ways to make better batteries or fuel cells and store chemical energy. So, with the same mode of thinking, we began studying small hydrocarbon rings and the energetics of ring strain that is imposed by having a trans oriented double bond. In general, it takes around 60 kcal/mol of energy to break a carbon‐carbon double bond, but it takes no more than about 20 kcal/mol to break a carbon‐carbon double bond in this small cyclic ring for the trans cis isomerization. We have attributed this lowering of activation energy to ring strain ‐ the ring is so strained in this conformation that it releases energy during the isomerization process. In particular, this research has focused on how the stability of the trans conformation is affected by different substituents. It is generally known that in linear alkenes a trans conformation for a double bond is more favored over the cis isomer as substituents become bulkier. It is also known that replacing the hydrogen atoms on a double bond with alkyl groups helps to stabilize the double bond. This research is centered on how much stability can be imposed on the trans‐isomer of these types of molecules to possibly allow them to exist at standard state conditions. Some trends are followed while some surprises were met. 178


POSTER ABSTRACTS 54

“Probing Phenylalanine/Adenine Π‐Stacking Interactions In Protein Complexes With Explicitly Correlated And CCSD(T) Computations” Kari L. Copeland and Gregory S. Tschumper* University of Mississippi, Department of Chemistry and Biochemistry, University, MS Abstract To examine the effects of π‐stacking interactions between aromatic amino acid side chains and adenine bearing ligands in crystalline protein structures, 26 toluene/(N9‐methyl‐ )adenine model configurations have been constructed from protein/ligand crystal structures. Full geometry optimizations with the MP2 method cause the 26 crystal structures to collapse to 6 unique structures. The complete basis set (CBS) limit of the CCSD(T) interaction energies have been determined for all 32 structures by combining explicitly correlated MP2‐R12 computations with a correction for higher‐order correlation effects from CCSD(T) calculations. The CCSD(T) CBS limit interaction energies of the 26 crystal structures range from −3.19 to −6.77 kcal mol‐1 and average −5.01 kcal mol‐1. The CCSD(T) CBS limit interaction energies of the optimized complexes increase by roughly 1.5 kcal mol‐1 on average to −6.54 kcal mol‐1 (ranging from −5.93 to −7.05 kcal mol‐1). Corrections for higher order correlation effects are extremely important for both sets of structures and are responsible for the modest increase in the interaction energy after optimization. The MP2 method overbinds the crystal by 2.31 kcal mol‐1 on average

compared to 4.50 kcal mol‐1 for the optimized structures. This data indicates that CCSD(T) computations are still necessary to obtain reliable interaction energies for π‐stacking systems even when they adopt the crystal structure geometry, where the fragments tend to be significantly further apart than at the gas‐phase optimized geometry. “A Photoacoustic Calorimetry Investigation Of The Excited‐State Properties Of The 55 Oxygen‐Transport Protein Hemerythrin” Shawna N. Lee*, Maurice Edington Florida A&M University, Department of Chemistry, Tallahassee, FL 32304 Abstract Hemerythrin is a dioxygen‐transport protein, whose oxygen‐binding site is a binuclear iron center. Spectroscopic investigations, including steady‐state absorption and photoacoustic calorimetry measurements have been conducted on hemerythrin in its met, oxy and azide forms. The results indicate all forms of hemerythrin studied exhibit a molecular volume expansion when the metal center charge‐transfer excited states are excited at 355 nm. Preliminary results convey that the met form of hemerythrin releases 70% of its absorbed energy as heat and the oxy form releases 90% of its absorbed energy as heat. The oxy form has a 40% larger volume expansion than the azide form. These 179


POSTER ABSTRACTS investigations will aid in our understanding of interactions that occur between the metal centers and the protein active site environment that are essential for dioxygen‐binding reactivity. “A Spectroscopic Investigation Of The Ultrafast Decay Dynamics Of The Dioxygen 56 Carrier Protein Hemocyanin” Tarah A. Word and Maurice Edington* Department of Chemistry, Florida A & M University, Tallahassee FL, 32307 ABSTRACT A series of spectroscopic investigations were preformed on the dioxygen carrier protein, hemocyanin (Hc), using time‐resolved laser spectroscopy in an attempt to understand how dioxygen (O2) reactivity is mediated by interactions between the copper center and the active‐site environment. Specifically, the methods of photoacoustic calorimetry and nanosecond transient absorption were used to gain insight into the environmental factors that mediate (O2) reactivity in hemocyanin. Currently, the excited state dynamics of the OxyHc metal center and the O2 binding/dissociation reactions are not well understood. Our results indicate that OxyHc releases ~76 % of the absorbed photon energy non‐ radiatively. This suggests that the O2 photodissociation quantum yield is ~24%. We will discuss these results and their impact on our current understanding of how the ligand binds to non‐heme metal centers. 57 “Identification Of Compact Basis Sets For The Reliable Characterization Of Higher‐ Order Correlation Effects In Π‐Type Interactions” Brittney D. Smith and Dr. Gregory S. Tschumper* The University of Mississippi Department of Chemistry and Biochemistry University, MS 38677 Abstract The dimers of acetylene (H − C ≡ C − H)2, cyanogen (N ≡ C− C ≡ N)2 and diacetylene (H − C ≡ C − C ≡ C − H)2 were used to examine the basis set dependence of higher‐order correlation effects on π‐type interactions. The parallel‐displaced and t‐shaped configurations were used for the cyanogen and diacetylene dimers while the stacked and t‐ shaped configurations were used for the acetylene dimer. Intermolecular interaction energies were calculated for each dimer configuration using the MP2, CCSD or CCSD(T) methods in conjunction with 16 different basis sets in order to identify compact basis sets that accurately reproduce higher‐order correlation corrections. 180


POSTER ABSTRACTS “Tunable Ag‐‐Nanoparticle Surface Plasmon Absorption And Its Effect On Surface Enhanced Raman Scattering (SERS) Activity” Christen M. Robinson, Dulal Senapati and *Paresh C. Ray Jackson State University, Department of Chemistry Jackson, MS‐39216 Abstract We have synthesized variable sized (4‐100 nm in diameter) Ag‐nanoparticles by Na‐citrate reduction method. Without changing the surfactant, simply by changing the ratio of Ag to Na‐citrate we have tuned the size of the Ag‐nanoparticles. Depending on their size, these nanoparticles show tunable surface plasmon bands (generally shows red shifting with increasing the diameter) with variable molar extinction coefficient. We have observed a two order (~100 times) enhancement of molar extinction coefficient by changing the diameter from 4nm to 100nm. Size and shape of these nanoparticles have been confirmed by TEM‐analysis. Using these tunable sized nanoparticles we have measured the Raman enhancement factor for Rh6G at 633nm which gives us an idea about the effect of nanoparticle size on polarizability and hence the surface enhanced Raman (SERS) activity. “A Preliminary Photoacoustic Calorimetry Investigation Of The Nonradiative 59 Relaxation Processes Of Photoactive Yellow Protein” Johnny Williams and Maurice Edington* Department of Chemistry, Florida A&M University, Tallahassee FL, 32307 ABSTRACT This investigation uses photoacoustic calorimetry to attain a comprehensive understanding of how the active‐site environment of Photoactive Yellow Protein mediates photochemical reactions exhibited by p‐coumaric acid and variants. This will allow us to characterize the nonradiative relaxation process of the photocycle, as well as give insight on key electrostatic interactions involved in stabilizing the chromophore photochemical reactions. This will bring our lab closer to our goal of understanding how light absorption induces chemical and conformational changes that subsequently trigger an unknown messenger to induce signal transduction. 58

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POSTER ABSTRACTS “Coupled Dielectric And Thermochemical Studies Of The Influence Of Curing Agent Structure On Epoxy-Amine Cure”

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Abdul-Rahman O. Raji*, Alvin P. Kennedy, and Solomon Tadesse Morgan State University, Department of Chemistry, Baltimore, MD 21251 Abstract Dielectric spectroscopy and differential scanning calorimetry have been used to monitor the isothermal cure of Diglycidyl Ether of Bisphenol A with 3, 3ʹ-DDS and 4, 4ʹ-DDS. Combination of both methods provides a powerful technique for understanding the morphology of network-forming epoxy-amine during cure. It is interesting that though the only difference in the structure of both curing agents is the location of their amine groups, there is a significant difference in their final glass transition temperature. Their in-situ dielectric properties also showed huge distinctions. The result of the experiments revealed that although the rate of reaction or the rate of network formation is higher for the 3, 3ʹDDS, it is not directly responsible for the disparity in the final glass transition temperature. “Laser Induced Breakdown Spectroscopy In Biological Systems” Marquis Gordon*, Tia Mitchell, Lewis Johnson, and Maurice Edington Department of Chemistry, Florida A&M University, Tallahassee FL, 32307

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Abstract This investigation assesses the use of Laser Induced Breakdown Spectroscopy as a rapid detection technique to identify and characterize various inorganic elements found in biological pathogens and toxins that could possibly be harmful to both humanity and the environment. We will explore the use of various combinations of LIBS configurations, such as single‐pulse and double‐pulse schemes, in order to optimize plasma generation and detection for the targeted samples. The ultimate goal of this work is to develop a LIBS system that will detect biological agents in more complex environments, such as food sources under atmospheric condition, as well as detect and prevent the transmission of biological pathogens and toxins, especially those identified as potential bioterrorism attacks.

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NATIONAL CONFERENCE COMMITTEE Conference Chair Sandra K. Parker The Dow Chemical Company

Core Team Chairs Meeting Planner & Site Logistics Tim O’Neill Leading Edge Marketing and Planning, Inc. Secondary Education Linda Davis

Conference Participation Ella L. Davis

Committee for Programs Action Services (CAPS)

Finance Lolita Grant, CPA National Treasurer

New Business Development Dale Mack Morehouse School of Medicine

Workshops/Symposiums/Technical Programs/Student Support Rebecca Tinsley, PhD & Sharon Kennedy, PhD Colgate Palmolive

Ex-Officio Member Victor McCrary, PhD ~ National President Johns Hopkins Applied Physics Laboratory

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NATIONAL CONFERENCE COMMITTEE Sub-Committees Health Symposium Ron Lewis PhD, Co-Chair Pfizer Inc., PGRD La Jolla

Meeting Planning/Site Logistics Tim O’Neill, Meeting Planner Leading Edge Marketing and Planning, Inc.

Patty Blanchard, Onsite Staff Leading Edge Marketing and Planning, Inc

Professional Development Workshops Sharon J. Barnes MBA/HRM The Dow Chemical Company

Printing/Publishing Tony Dent, PhD, Chair Retiree, PQ Corporation

Guest Speakers William Jackson PhD, Chair University of California, Davis

Steven Thomas Webmaster

Awards & Student Programs Sharon Kennedy PhD, Chair Colgate Palmolive

New Business Development Dale Mack, Chair Morehouse School of Medicine

Christine Grant PhD University of North Carolina

Cassandra Broadus Morehouse School of Medicine

Alvin Kennedy PhD Morgan State University

Darrell Davis Committee for Program Action Services (CAPS)

Andre Palmer PhD The Ohio State University

Derry Haywood The Peninsula Financial Group

Rebecca Tinsley, PhD Colgate Palmolive Company

Victor McCrary, PhD Johns Hopkins Applied Physics Laboratory

Nikisha Bent Rohm and Haas Company Technical Workshops & Symposiums Rebecca Tinsley PhD, Co-Chair Colgate Palmolive

Calvin James Lubrizol Corporation

Dale Wesson PhD Florida A&M University

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NATIONAL CONFERENCE COMMITTEE Proceedings Tommie Royster PhD, Chair Eastman Kodak Company

Career Expo Dale Mack, Co-Chair Morehouse School of Medicine

Dinah Jordan Princeton University

Dr. Kenneth Smith, Co-Chair Elementis Specialties

Alison Williams PhD Princeton University

Rasheda Weathers Drug Enforcement Administration

Jesse Edwards PhD Florida A&M University

Henry Beard

Teachers Workshop Linda Davis, Chair

Conference Registration Felicia Barnes-Beard, Co-Chair Rohm and Haas Company

Committee for Action Program Services (CAPS)

Ella L. Davis, Co-Chair

Sheila Turner Marine Corp Recruit Depot

Brenda Brown San Diego Unified School District

Joyce Chesley-Dent Retiree, Federal Government

Celeste Tidwell San Diego Unified School District

Jennifer Stimpson Dallas Independent School District

Shirley Hall Retiree, San Diego City Government

Science Bowl/Science Fair Saphronia Johnson, Co-Chair Benedict College

Dorothy Haynes Kiana Hamlett, Co-Chair Drug Enforcement Administration

Henry Beard

Sheila Turner Marine Corp Recruit Depot

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“I get to do high level science everyday. I’m also able to try to inspire our younger generation’s interest in science. This is really my dream job.” Roche, United States

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TSU H‐LSAMP PERSONNEL Dr. Bobby Wilson Project Director, Shell Oil Endowed Chair of Environmental Toxicology, and L. Lloyd Woods Distinguished Professor of Chemistry Dr. Willie Taylor Associate Director and Professor of Mathematics Ms. Michelle Tolbert Program Coordinator Texas Southern University 3100 Cleburne Street Houston, Texas 77004 Phone: (713) 313-4278 Website: www.em.tsu.edu/LSAMP Email: LSAMPScholarship@tsu.edu

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