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ANNUAL REPORT

2016


THE SACKLER INSTITUTE FOR NUTRITION SCIENCE STAFF IN 2016 Gilles Bergeron, PhD Executive Director Mireille Mclean, MA, MPH Director Megan Bourassa, PhD Program Manager Lindsay Monaco, MPH Program Coordinator For the Global Compact on Early Childhood Development: Charles Gardner, PhD Program Manager

BOARD COMMITTEE MEMBERS Barbara Burlingame, PhD Professor, Massey University Antonio Convit, MD Deputy Director, The Nathan S. Kline Institute for Psychiatric Research Elaine Fuchs, PhD Professor, Rockefeller University Brooke Grindlinger, PhD Executive Director, Scientific Programs, The New York Academy of Sciences Nabeeha Kazi-Hutchins, MIA, MPH President and Chief Executive Officer, Humanitas Global Bruce McEwen, PhD Professor, Rockefeller University Rafael Perez-Escamilla, PhD Professor, Yale University Ellis Rubinstein President and Chief Executive Officer, The New York Academy of Sciences

Kathe A. Sackler, MD Founder and President, The Acorn Foundation for the Arts & Sciences Mortimer D.A. Sackler Member of the Board, Purdue Pharma Josette Sheeran President, Asia Society Emorn Udomkesmalee, PhD Senior Advisor, Mahidol University Jan Weststrate, PhD Senior Vice President, Global Functions, Governance & Compliance, PepsiCo TC Westcott Executive Vice President & Chief Operating Officer, The New York Academy of Sciences Michael Zigman Founder, i2 Learning

RECOMMENDATION FOR QUOTING: The Sackler Institute for Nutrition Science 2016 Annual Report (2017). New York, NY: The New York Academy of Sciences. ©The Sackler Institute for Nutrition Science (2016). All rights reserved.

EDITORS Mireille Mclean, MA, MPH Director Lindsay Monaco, MPH Program Coordinator Design Katherine Coffey

AVAILABLE ONLINE www.nyas.org/NutritionAnnualReport2016


ABOUT US THE SACKLER INSTITUTE FOR NUTRITION SCIENCE The New York Academy of Sciences, in partnership with The Mortimer D. Sackler Foundation, established The Sackler Institute for Nutrition Science to create a coordinated effort to support and disseminate nutrition science research. The Sackler Institute for Nutrition Science is dedicated to advancing nutrition science research and knowledge, mobilizing communities, and translating this work into the field. The Sackler Institute is generating a coordinated network across sectors, disciplines, and geographies that promotes open communication; encourages exchange of information and resources; nurtures the next generation of scientists; and affects community intervention design and public policy changes. Visit us online at www.nyas.org/SacklerInstitute

THE NEW YORK ACADEMY OF SCIENCES The New York Academy of Sciences is an independent, not-for-profit organization that since 1817 has been committed to advancing science, technology, and society worldwide. With more than 20,000 members in 100 countries around the world, the Academy is creating a global community of science for the benefit of humanity. The Academy’s core mission is to advance scientific knowledge, positively impact the major global challenges of society with science-based solutions, and increase the number of scientifically informed individuals in society at large. Visit us online at www.nyas.org

STAY CONNECTED WITH THE SACKLER INSTITUTE Facebook: https://www.facebook.com/SacklerNutritionScience LinkedIn: http://bit.nyas.org/sacklerlinkedin https://twitter.com/nyasnutr eAlerts: Visit www.nyas.org/Subscribe and select the Nutrition eNewsletter


CONVENING FOR IMPACT The Sackler Institute for Nutrition Science convenes scientific conferences on a variety of interdisciplinary topics — from the microbiome, to the protein supply chain and food s  ecurity. We asked our conference attendees about the effects of attending Sackler I nstitute conferences.*

5%

ATTENDEES WORK IN: 30% 12% 18% 12% 14% 5%

ACADEMIA INDUSTRY HEALTHCARE STUDENT/POSTDOC/FELLOW NOT-FOR-PROFIT GOVERNMENT

AS A RESULT OF ATTENDING:

33% 47% 98% 74%

altered the course of their research expanded a colleague’s professional network gained knowledge in nutrition, agriculture, or public health had a valuable conversation with a new contact

14%

12%

% 18%

81% 15%

30%

12%

of attendees plan to attend a future event

of attendees are underrepresented minorities in science

To view information about upcoming Sackler Institute conferences, visit www.nyas.org/nutrition *Based on a confidential online survey of attendees of Sackler Institute events in 2015. N = 95 (out of 799 attendees, a 12% response rate).

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TABLE OF CONTENTS From The Executive Director

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2016 at a Glance

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The Sackler Institute for Nutrition Science Research Fund – A focus on Adolescent Women

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The Collaborative Initiative for Adolescent Nutrition

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Using Electronic Health Records to Assess the Determinants of Adolescent Nutrition in New York City

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The Sackler Institute Annual Research Award

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Malaysia Project

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Scientific Conferences

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Technology and Innovation in Agriculture, Food, and Nutrition

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Obesity, Diabetes, and Nutrition-Related Diseases: a Focus on Systems and Policy

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Nutrition and Aging

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Meetings

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Media

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Annals of the New York Academy of Sciences Volumes

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Annals of the New York Academy of Sciences Articles

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Other Nutrition Initiatives at The New York Academy of Sciences

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2017 Working Group Initiatives

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2017 Collaboration Opportunities

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Thank You to Our Supporters

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FROM THE EXECUTIVE DIRECTOR With 2016 coming to a close, we look back at an inspiring and challenging year. We complied with a very full agenda, while defining and enacting a new strategic direction. The Sackler Institute Board Committee, the directorate of the New York Academy of Sciences, and the exceptional staff of the Sackler Institute all have to be thanked for their superlative support as I, in my first year at the Sackler Institute, took on the task of laying out our future directions and initiatives. The accomplishments in 2016 were impressive, and touched upon many of the issues currently facing the field of nutrition. In April, we organized with WHO and FAO a global consultation on bio-fortification. This was followed in June by the hosting of a conference on the use of antibiotics in animal production where prudent antibiotics stewardship approaches were addressed. Our “deep-dive” initiative on Adolescent Women Nutrition saw important advances with a technical consultation in July that laid out what is known and is being done on this front; and a gathering in November of our 2016 Small Research Grants awardees, focused on documenting the state of adolescent nutrition worldwide. Our work on obesity and diabetes continued in September with a conference on the use of Big Data in obesity research, followed by the release of a Request for Proposal for early-career scientists to develop digital tools for obesity prevention and control. Our earlier work on Early Child Development (ECD) saw a strong sequel with the creation of a city-focused Global Compact for ECD, and the first meeting in December of the ECD “Early Adopter Cities” network. Our 2016 events cycle closed with a conference on nutrition and the elderly, considering the key role of nutrition for healthy aging. Our three advisory working groups (on Obesity; on Aging; and on Technology and Innovation) met at several junctures to design the content of next year’s investment. And a mission to Kota Bharu crowned the excellent collaboration we had over the years with Malaysia’s government to make nutrition a central aspect of their workplace policy. As those activities were taking place, the Sackler Institute was gearing up for 2017, making a deliberate effort to promote the translation of science into public use, and to progress on “Discovery to Delivery” pathway. Upcoming activities offer a good example of what that means: we will clarify the extent of micronutrient deficiencies, associated disease burdens and programmatic options, to support palliative actions and investments. We will also examine the challenges posed by the sustainable production of nutritious foods; and we are laying the ground for establishing a consortium to improve the use and communication of science to the public. Publications associated with our initiatives will see the light on adolescent women nutrition; micronutrient deficiencies; and decision making tools for nutrition policy. With all this in store, the Sackler Institute stands ready to pair its well established reputation for quality science with a deeply held concern for public utility, and to amplify its voice in the nutrition community and the public arena. Thank you in advance for your continued enthusiasm and commitment. Gilles Bergeron, PhD Executive Director

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EN

4 Conferences

15

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totaling 2 Podcasts, 4,773 downloads

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in-person conference attendees

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254

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peer-reviewed articles in 3 Annals 26 26 of the New York Academy of Sciences volumes, totaling

16,040 downloads

28,488 eBriefing views in 2016 121,643 10,629 eBriefing views total Sackler Institute 2016 webpage views

across 27 eBriefings since 2011

2,323

SAC K

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39

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Scientific Organizing Committee & Advisory Group members

K OR W

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social media members

57

Speakers Research Teams Funded in 2016, Totaling

15 $600,000

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in Research Awards

2016

AT A GLANCE 7


THE SACKLER INSTITUTE FOR NUTRITION SCIENCE RESEARCH FUND – A FOCUS ON ADOLESCENT WOMEN The Sackler Institute’s Research Fund provides a mechanism to allocate internal and external (matched) resources to research grants aligned with the Global Research Agenda for Nutrition Science (2013).

THE COLLABORATIVE INITIATIVE FOR ADOLESCENT NUTRITION In November 2016, the Sackler Institute convened for the first time all the grantees that had been supported to conduct research specifically on adolescent nutrition. During this two-day meeting, the findings from the research were presented and discussed. Scientists used observational studies to explore the links between nutritional status, diet and other predictors such as physical activity, socioeconomic status, maternal education etc. Trial

studies also highlighted the fact that results from interventions may differ among adolescent women compared to adolescent boys and adults. The discussions suggest that priorities should focus on better understanding the trajectory of adolescents, not only in terms of growth but also in terms of occupation, whether they are at home, in school, or working; as well as on promoting the development of adolescent-friendly delivery platforms for health and nutrition interventions.

Grant presentations included: Linda Adair, The University of North Carolina at Chapel Hill A life-course Perspective on Adolescent Nutrition in the Philippines Jere Behrman and Whitney Schott, University of Pennsylvania Drivers and Mediating Factors of Nutritional Status in Adolescent Women and their Children in Ethiopia, India, Peru and Vietnam Kathryn Dewey, University of California, Davis Nutritional Status and Birth Outcomes in Pregnant Adolescent Women in Rural Bangladesh Yuna He, National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention Nutritional Statues and Dietary Intake of Chinese Adolescent Women Jef Leroy, International Food Policy Research Institute Understanding the Determinants of Adolescent Women’s Nutritional Status in Bangladesh: Analyses of the 2012-13 Nationally Representative Bangladesh Integrated Household Survey

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Radhika Madhari, National Institute of Nutrition (Indian Council of Medical Research) Diet and Nutrient Adequacy, Nutritional Status and its Determinants Among Adolescent and Adult Women in India Zandile Mchiza, Human Sciences Research Council of South Africa The Girl - Adult Woman Comparison Study: The Nutritional Status and Metabolic Disease Risk Profile of South African Women (10+ years) Shane Norris, MRC Developmental Pathways for Health Research Unit, University of the Witwatersrand, South Africa Longitudinal Model of Urban Adolescent Nutritional Status: Risk Factors and Consequences (South Africa) Kate Ward, MRC Human Nutrition Research Dietary Determinants of Nutritional Status Among Gambian Adolescent Girls and Young Women

USING ELECTRONIC HEALTH RECORDS TO ASSESS THE DETERMINANTS OF ADOLESCENT NUTRITION IN NEW YORK CITY The Sackler Institute for Nutrition Science continued its partnership with Rockefeller University and the Clinical Directors Network, Inc. to explore the determinants of adolescent women’s nutritional status and potential implications for pregnancy outcomes, using Electronic Health Records (EHR). The current cohort now includes nearly 50,000 unique individual female adolescent aged 12 to 20 year-old, of which 43% are overweight and obese, and 17% have a recorded pregnancy. Efforts are focusing on data quality improvement and interpretation of key associations between BMI, metabolic health and pregnancy outcomes, to demonstrate the value of using EHR as a rapid assay for population studies. In 2017, the program will also investigate the use of nutrition education in primary care setting.

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THE SACKLER INSTITUTE ANNUAL RESEARCH AWARD Granted February 2016 The Sackler Institute awarded three researchers with $50,000 each in early 2016 to pursue innovative research projects related to obesity, aging and agriculture. The research award is intended to provide support to researchers concentrating their work on under-explored, and often under-funded, research topics.

Award Winners Research award winners were selected from a pool of 18 high-quality proposals by eight expert reviewers. Winners include the following researchers: Shauna Downs, Columbia University Identifying Interventions to Promote the Production and Consumption of Healthy and Sustainable Oils in Myanmar “As the global population and growth in per capita income increases, our current food system will struggle to meet demand for sustainable, nutritious food in the face of multiple constraints including climate change and ecosystem preservation. There is a clear need to do more with less and in a ‘better’ way.” Xinyin Jiang, Brooklyn College, City University of New York Prenatal Betaine Supplementation as a Treatment for Macrosomia in a Mouse Model of Gestational Diabetes Mellitus “In Gestational Diabetes Mellitus (GDM)complicated pregnancies, placental transport of fatty acids and glucose to the fetus is

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significantly elevated, resulting in fetal overgrowth, or macrosomia. Macrosomia predisposes infants to a greater risk of obesity and diabetes later in life.” Rena Zelig, Rutgers School of Health Related Professions Exploring the Associations between Dentition Status, Nutritional Status, and the Eating Experience in Older Adults — A Mixed Methods Study “The relationship between nutrition and oral health is synergistic. However, the impact of missing teeth and poor dentition on nutritional status and the eating experience has not been studied from the patient perspective.”


MALAYSIA PROJECT MYBFF WORKSHOP: BEHAVIOR CHANGE INTERVENTIONS IN NUTRITION The Institute for Public Health, Ministry of Health Malaysia, convened a U.S. delegation and My Body is Fit and Fabulous (MyBFF) program constituents during a symposium on July 17 and workshops on July 18 and 19, 2016. The symposium and workshop were held in Kota Bharu, Kelantan. The goal of the symposium was to share outcomes from the MyBFF programs and for the U.S. delegation

to provide insights into similar U.S. programs and outcomes, specifically looking at behavior change interventions for childhood obesity prevention. The goal of the workshop was to foster a greater understanding of the MyBFF programs to demonstrate program impact and provide justification for nationwide dissemination.

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SCIENTIFIC CONFERENCES The Sackler Institute offers the nutrition community access to the latest scientific developments in nutrition and related disciplines through a set of mission-driven program activities including public scientific conferences. Bringing together international experts and partners from academia, industry, government, and beyond, the Sackler Institute provides a neutral forum for participants to exchange critical nutrition research findings.

TECHNOLOGY AND INNOVATION IN AGRICULTURE, FOOD, AND NUTRITION

OBESITY, DIABETES, AND NUTRITIONRELATED DISEASES: A FOCUS ON SYSTEMS AND POLICY Big Data, Consumer Technology, and the Obesity Epidemic: Emerging Science and Ethical Considerations Antibiotics in Food: Can Less Do More? June 3, 2016 This event explored the use of antibiotics in animal-rearing, raising questions about antibiotic resistance, reduction in antibiotic use, and the dynamics between food supply, food safety and public health. The first Sackler Institute livestream featured a panel discussion about alternative options, including probiotics, bacteriophages.

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September 16, 2016 This conference brought together researchers, health professionals, and a growing wellnessconscious public to discuss the use of technology to monitor health status, particularly weight and energy balance. A unique legal perspective was introduced discussing the ethics of big data harnessed from electronic medical records, smart phone applications and consumer purchasing behaviors.


NUTRITION AND AGING Aging and Nutrition: Novel Approaches and Techniques December 2, 2016 This symposium discussed several pioneering interventions to extend the healthy lifespan of mammals, including caloric restriction, genome engineering, high-throughput sequencing, and DNA methylomics. Speakers explored how alterations in nutrition and metabolism can have profound effects on healthy aging. This symposium was co-presented by the Orentreich Foundation for the Advancement of Science, Inc. Digital media was sponsored by Abbott Nutrition Health Institute.

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MEETINGS Along with hosting public scientific conferences, the Sackler Institute convenes experts for small, closed-door meetings. Many of these meetings are working sessions, where attendees are gathered to deliberate on a specific task. Ongoing meetings consist of three Sackler Institute Board meetings and in-person meetings of the three Sackler Institute Working Groups: • Technology and Innovation in Agriculture, Food, and Nutrition • Obesity, Diabetes, and Nutrition-Related Diseases • Nutrition for Aging Populations

The Sackler Institute Board Committee Meeting February 4, May 5, and September 15, 2016

Clinical Advisers Consultative Meeting on Clinical Nutrition and Services of Research Learning with Adolescent Women February 12, May 13, September 14, and November 2, 2016

Technical consultation: Staple Crops Biofortified with Vitamins and Minerals: Considerations for a Public Health Strategy April 6-8, 2016

Technology and Innovation in Agriculture, Food, and Nutrition Working Group In-Person Annual Meeting June 2, 2016

Malaysia Ministry of Health Conference & Workshop July 17-19, 2016

Nutrition in Adolescent and Young Women Meeting Consensus-Building Meeting July 21-22, 2016

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Obesity, Diabetes, and NutritionRelated Diseases Annual Working Group In-Person Annual Meeting September 15, 2016

Grantee Meeting: results of studies using existing dataset to investigate the nutritional status of Adolescent Girls and Young Women November 3-4, 2016

Global Compact for Early Childhood Development: Workshop on Cities, Science and Nurturing Care November 30-December 1, 2016

Nutrition for Aging Populations Working Group In-Person Annual Meeting December 2, 2016


MEDIA PODCASTS

LIVESTREAMS Reasonable Use of and Alternatives for Antibiotics in the Food System Aging and Nutrition: Novel Approaches and Techniques New York Academy of Sciences Academy News Big Data Boosts Obesity Research Results

GUEST BLOGS Little Beans, Big Opportunities

Antibiotics In Food: Can Less Do More?

For 2016, the International Year of Pulses, we explore the many opportunities provided by pulses—edible seeds like dried, lentils, and chickpeas.

Antibiotics in the Food System Antibiotic Reduction: How to Shape a Healthier Food Supply

Building an Evidence Base for Effective Obesity Policy We explore research methodologies for building an evidence base for nutrition and obesity policy that are emerging across disciplines.

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ANNALS OF THE NEW YORK ACADEMY OF SCIENCES VOLUMES Annals of the New York Academy of Sciences is one of the oldest scientific serial publications in the United States and among the most cited multidisciplinary scientific serials worldwide. Continually published since 1823, Annals is the premier publication of the Academy, offering review articles in special topical areas and proceedings of conferences sponsored by the Academy as well as other scientific organizations. The Sackler Institute provides funding for the following open-access volumes and articles.

Nutrition in Prevention and Management of Dementia March 2016, Volume 1367 Vitamin B1 and dementia Vitamin D in dementia prevention Improving food intake in persons living with dementia

special issue

Nutrition in Prevention and Management of Dementia

Annals Editor-in-Chief: Douglas Braaten, PhD Impact Factor: 4.518 ISI Journal Citation Reports Š Ranking: 2015: 8/63 (Multidisciplinary Sciences) www.nyas.org/publications/Annals

Edited by Annals of the New York Academy of Sciences editorial staff This Annals issue discusses emerging nutrition research on the prevention and management of dementia in aging populations.

Diet, Sulfur Amino Acids, and Health Span January 2016, Volume 1363

Fortification of Condiments and Seasonings with Vitamins and Minerals in Public Health II Fortification with micronutrients in public health Estimating nutrient fortification levels for public health As vehicles in large-scale fortification programs

special issue

-VY[PĂ„JH[PVUVM*VUKPTLU[ZHUK :LHZVUPUNZ^P[O=P[HTPUZHUK 4PULYHSZPU7\ISPJ/LHS[O00

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September 2016, Volume 1379 Edited by Annals of the New York Academy of Sciences editorial staff

Significant Life Extension by Ten Percent Dietary Restriction Manipulation of Health Span and Function by Dietary Caloric Restriction Mimetics

Edited by Annals of the New York Academy of Sciences editorial staff

Methionine Restriction Beyond Life-Span Extension

special issue

Diet, Sulfur Amino Acids, and Health Span

This Annals issue explores the effects of dietary and sulfur amino acid restriction on health span, aging, and disease progression, from the molecular to the phylogenic level.


ANNALS OF THE NEW YORK ACADEMY OF SCIENCES ARTICLES Fortification of Condiments and Seasonings with Vitamins and Minerals in Public Health II September 2016, Volume 1379 Edited by Juan Pablo Peña-Rosas (World Health Organization) and Maria Nieves Garcia-Casal (Venezuelan Institute for Scientific Research), and Luz María De-Regil (Micronutrient Initiative) García-Casal, M.N., Peña-Rosas, J.P., Malavé, H.G. (2016), Sauces, spices, and condiments: definitions, potential benefits, consumption patterns, and global markets. Annals of the New York Academy of Sciences, 1379: 3–16. doi: 10.1111/ nyas.13045 Garcia-Casal, M.N., Peña-Rosas, J.P., Mclean, M., De-Regil, L.M., Zamora, G. (2016), Fortification of condiments with micronutrients in public health: from proof of concept to scaling up. Annals of the New York Academy of Sciences, 1379: 38–47. doi: 10.1111/nyas.13185 Jalal C., Wuehler S., Osendarp S., María De-Regil, L. (2016), Estimating nutrient fortification levels in condiments and seasonings for public health programs: considerations and adaptations. Annals of the New York Academy of Sciences, 1379: 28–37. doi: 10.1111/nyas.13227 Zamora G., Flores-Urrutia M.C., Mayén A.L. (2016), Large-scale fortification of condiments and seasonings as a public health strategy: equity considerations for implementation. Annals of the New York Academy of Sciences, 1379: 17–27. doi: 10.1111/nyas.13183

Nutrition in Prevention and Management of Dementia March 2016, Volume 1367 Edited by Annals of the New York Academy of Sciences editorial staff Annweiler, C. (2016), Vitamin D in dementia prevention. Annals of the New York Academy of Sciences, 1367: 57–63. doi: 10.1111/nyas.13058 Cunnane, S.C., Courchesne-Loyer, A., St-Pierre, V., Vandenberghe, C., Pierotti, T., Fortier, M., Croteau, E., Castellano, C.A. (2016), Can ketones compensate for deteriorating brain glucose uptake during aging? Implications for the risk and treatment of Alzheimer’s disease. Annals of the New York Academy of Sciences, 1367: 12–20. doi: 10.1111/nyas.12999 Gibson, G.E., Hirsch, J.A., Fonzetti, P., Jordan, B.D., Cirio, R.T., Elder, J. (2016), Vitamin B1 (thiamine) and dementia. Annals of the New York Academy of Sciences, 1367: 21–30. doi: 10.1111/nyas.13031 Keller, H.H. (2016), Improving food intake in persons living with dementia. Annals of the New York Academy of Sciences, 1367: 3–11. doi: 10.1111/nyas.12997 Morris, M.C. (2016), Nutrition and risk of dementia: overview and methodological issues. Annals of the New York Academy of Sciences, 1367: 31–37. doi: 10.1111/nyas.13047 Tucker, K.L. (2016), Nutrient intake, nutritional status, and cognitive function with aging. Annals of the New York Academy of Sciences, 1367: 38–49. doi: 10.1111/nyas.13062 Schelke, M.W., Hackett, K., Chen, J.L., Shih, C., Shum, J., Montgomery, M.E., Chiang, G.C., Berkowitz, C., Seifan, A., Krikorian, R., Isaacson,

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Diet, Sulfur Amino Acids, and Health Span January 2016, Volume 1363 Edited by Annals of the New York Academy of Sciences editorial staff Ables, G.P., Hens, J.R., Nichenametla, S.N. (2016), Methionine restriction beyond life-span extension. Annals of the New York Academy of Sciences, 1363: 68–79. doi: 10.1111/nyas.13014 Anunciado-Koza, R.P., Manuel, J., Koza, R.A. (2016), Molecular correlates of fat mass expansion in C57BL/6J mice after short-term exposure to dietary fat. Annals of the New York Academy of Sciences, 1363: 50–58. doi: 10.1111/nyas.12958 Brown-Borg, H.M. (2016), Reduced growth hormone signaling and methionine restriction: interventions that improve metabolic health and extend life span. Annals of the New York Academy of Sciences, 1363: 40–49. doi: 10.1111/nyas.12971 Chernyavskiy, I., Veeranki, S., Sen, U., Tyagi, SC. (2016), Atherogenesis: hyperhomocysteinemia interactions with LDL, macrophage function, paraoxonase 1, and exercise. Annals of the New York Academy of Sciences, 1363: 138–154. doi: 10.1111/nyas.13009 Figueiredo-Pereira, M.E., Corwin, C., Babich, J. (2016), Prostaglandin J2: a potential target for halting inflammation-induced neurodegeneration. Annals of the New York Academy of Sciences, 1363: 125–137. doi: 10.1111/nyas.12987 Huang, T.H., Ables, G.P. (2016), Dietary restrictions, bone density, and bone quality. Annals of the New York Academy of Sciences, 1363: 26–39. doi: 10.1111/nyas.13004 Kruger, W.D., Gupta, S. (2016), The effect of dietary modulation of sulfur amino acids on cystathionine β synthase-deficient mice. Annals of the New York Academy of Sciences, 1363: 80–90. doi: 10.1111/nyas.12967

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Lee, B.C., Kaya, A., Gladyshev, V.N. (2016), Methionine restriction and life-span control. Annals of the New York Academy of Sciences, 1363: 116–124. doi: 10.1111/nyas.12973 McIsaac, R.S., Lewis, K.N., Gibney, P.A., Buffenstein, R. (2016), From yeast to human: exploring the comparative biology of methionine restriction in extending eukaryotic life span. Annals of the New York Academy of Sciences, 1363: 155–170. doi: 10.1111/nyas.13032 Mentch, S.J., Locasale, J.W. (2016), One-carbon metabolism and epigenetics: understanding the specificity. Annals of the New York Academy of Sciences, 1363: 91–98. doi: 10.1111/nyas.12956 Mullin, J.M., Skrovanek, S.M., Ramalingam, A., DiGuilio, K.M., Valenzano, M.C. (2016), Methionine restriction fundamentally supports health by tightening epithelial barriers. Annals of the New York Academy of Sciences, 1363: 59–67. doi: 10.1111/nyas.12955 Niewiadomski, J., Zhou, J.Q., Roman, H.B., Liu, X., Hirschberger, L.L., Locasale, J.W., Stipanuk, M.H. (2016), Effects of a block in cysteine catabolism on energy balance and fat metabolism in mice. Annals of the New York Academy of Sciences, 1363: 99–115. doi: 10.1111/nyas.13021 Richardson, A., Austad, S.N., Ikeno, Y., Unnikrishnan, A., McCarter, R.J. (2016), Significant life extension by ten percent dietary restriction. Annals of the New York Academy of Sciences, 1363: 11–17. doi: 10.1111/nyas.12982 Roth, G.S., Ingram, D.K. (2016), Manipulation of health span and function by dietary caloric restriction mimetics. Annals of the New York Academy of Sciences, 1363: 5–10. doi: 10.1111/nyas.12834 Selhub, J., Troen, A.M. (2016), Sulfur amino acids and atherosclerosis: a role for excess dietary methionine. Annals of the New York Academy of Sciences, 1363: 18–25. doi: 10.1111/nyas.12962


OTHER NUTRITION INITIATIVES AT THE NEW YORK ACADEMY OF SCIENCES GLOBAL COMPACT FOR EARLY CHILDHOOD DEVELOPMENT: WORKSHOP ON CITIES, SCIENCE AND NURTURING CARE November 30 – December 1, 2016

The first “early adopter cities” workshop of the Global Compact for Early Childhood Development included mayors and other senior civic officials from 13 cities in Asia, Europe, Latin America and North America. These City delegations were joined by some of the world’s leading experts in the field of early childhood development (ECD). The workshop focused on how cities can improve the lives of their youngest children by strengthening prenatal health and nutrition (“ECD in the womb”); parenting programs (“ECD in the home”), family centers,

day care, and the built environment (“ECD outside the home”). One of the key challenges in the ECD field is linking health, nutrition, education and social services. The rich exchange of ideas and experiences has already stimulated the development of new city programs in Brazil and The Philippines, and has strengthened efforts to measure outcomes in several cities. This event was sponsored by the Bezos Family Foundation, the David and Lucile Packard Foundation, and the Robert Wood Johnson Foundation.

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2017 WORKING GROUP INITIATIVES As The Sackler Institute moves towards convening for impact, we have developed several long term initiatives with each working group.

OBESITY, DIABETES, AND NUTRITION-RELATED DISEASES WORKING GROUP Metabolic Fitness The goal of the initiative will be centered on changing the public mindset towards markers of metabolic fitness rather than simply reducing weight or BMI.

Members: Jamy Ard, MD Wake Forest Baptist Health Center Hj Tahir Aris, PhD Institute for Public Health Malaysia Ministry of Health Sanjay Basu, MD, PhD Stanford Prevention Research Center Jason Block, MD, MPH Harvard Medical School Juan Rivera Dommarco, PhD National Institutes of Public Health, Mexico Susan Finn, PhD, RD, FADA American Council for Fitness & Nutrition

Ruth Kimokoti, MD, MA, MPH Simmons College Gurpreet Kalra, MS Memorial Sloan Kettering Cancer Center John G. Kral, MD, PhD, FACS SUNY Downstate Medical Center Blandine Laferrere, MD Columbia University College of Physicians and Surgeons Kristina H Lewis, MD, MPH, MS (Chair) Public Health Sciences at Wake Forest University Barbara E. Millen, DrPH, RD, FADA Millennium Prevention, Inc Andrew G. Swick, PhD Life Extension Karen Teff, PhD National Institute of Diabetes and Digestive and Kidney Diseases Claire Wang, MD, ScD Columbia University

NUTRITION FOR AGING POPULATIONS WORKING GROUP Biomarkers of Nutrition for Healthy Brain Aging This multi-year initiative seeks to create a research agenda to evaluate existing and novel biomarkers of nutritional status in the brain.

Hidden Hunger among the Elderly This initiative would seek to bring attention to the issue of hidden hunger among the elderly and support the call to action to address this issue.

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Members: Jane Durga, PhD Pamlab Yvonne Freund-Levi, MD, PhD Karolinska Institutet Fran Grodstein, ScD Harvard School of Public Health


Deb Gustafson, PhD SUNY Downstate Medical Center University of Gothenburg Gordon Jensen, MD, PhD University of Vermont Miia Kivipelto, PhD Karolinska Institutet

Menghua Luo, MD, PhD Abbott Nutrition Simin Meydani, DVM, PhD Jean Mayer USDA HNRCA at Tufts University Katherine Tucker, PhD University of Massachusetts, Lowell

Lenore Launer, PhD National Institute on Aging

TECHNOLOGY AND INNOVATION FOR AGRICULTURE, FOOD, AND NUTRITION WORKING GROUP Risk vs. Reward in Food: Identifying Best Practices for Communicating Food Industry Practices to the Consumer

Bruce Cogill, PhD Julianne Curran, PhD Pulse Canada

This initiative will seek to emphasize the need for consistency between communicating nutrition benefits and food safety risks, identify good risk assessment and communication practices in the context of the new FSMA and FDA regulations and acknowledge and refresh existing guidelines for communicating scientific research.

Jessica Fanzo, PhD Johns Hopkins University

Members:

Girish Ganjyal, PhD Washington State University

Riccardo Accolla, PhD A-T4H Consulting, VIVA Nutritional Product LLC

Tim Freier, PhD Merieux NutriSciences Jeffrey M. Farber, PhD University of Guelph

Juan M. Gonzalez, PhD, MBA

Gary Acuff, PhD Texas A&M Center for Food Safety

Prabhu L. Pingali, PhD Cornell University

Nelson G. Almeida, PhD, FACN Kellogg Company

Kara Rubin BeyondBrands, Simpactful

Robert E. Brackett, PhD Illinois Institute of Technology

Frank Yiannas Walmart 

Norberto Chaclin, MBA PepsiCo

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2017 COLLABORATION OPPORTUNITIES The Sackler Institute leverages and builds on the reputation of the New York Academy of Sciences to convene experts from multiple sectors and foster transformative partnerships in the field of nutrition. By acting as a forum for debate, analysis, networking, and convening, the Sackler Institute provides key advantages for partners and supporters.

THERE ARE MULTIPLE WAYS TO ENGAGE WITH THE SACKLER INSTITUTE Engagement with the Sackler Institute as a supporter can take many forms, including Partnerships, Leadership Initiatives, Special Projects, and Working Group and Conference Sponsorships. The Sackler Institute also welcomes additional support through customized opportunities. Collaborations allow organizations to participate in the ongoing activities of the Sackler Institute in substantive ways, and provide numerous possibilities for organizations and their leadership and researchers to engage scientifically with the Sackler Institute.

As a Co-presenting Partner: Co-presenting partners provide substantial financial support for a scientific public conference. Roles and responsibilities of all stakeholders in the partnership are formally laid out in a Letter of Agreement. In collaboration with the Scientific Organizing Committee, co-presenting partners are closely associated with the development of the conference content which provides an excellent venue for institutions who want to be actively engaged in scientific discussions. A Co-presenting partner: • Can nominate one scientist with relevant expertise to the Scientific Organizing Committee • Is acknowledged on the event webpage, marketing materials, and on enduring materials, as laid out in the Letter of Agreement

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• Is allocated 5- 20 complimentary registrations for its employees or affiliates, depending on the contributing level • Cannot promote its products during the conference or in conference communication. If all conference costs are not defrayed by a presenting partner, the Sackler Institute has full autonomy to seek additional support

As a Sponsor A Sponsor provides financial support in furtherance of an already established Scientific Conference or Working Group (topic is decided and scientific organizing committee has been assembled). Sponsors receive corresponding recognition for their support in live and enduring activity materials related to the Scientific Conference. Sponsors are not engaged in activity development, and the role of the sponsor is clearly stated alongside the support they provide. Being a sponsor provides an opportunity to gain visibility among an audience that shares similar interests.


THANK YOU TO OUR SUPPORTERS Programs of the Sackler Institute are supported by the Mortimer D. Sackler Foundation. In addition, grants and collaborations with funders enable us to further develop specific activities, benefiting our large network of scientists and elevating the role of nutrition science in public health.

2016 activities were supported by: Abbott Nutrition and the Abbott Nutrition Health Institute as co-presenting partners for digital media for a technical meeting Bezos Family Foundation as sponsor of a technical meeting David & Lucile Packard Foundation as sponsor of a technical meeting Friesland Campina as sponsor of the Research Fund

Robert Wood Johnson Foundation as sponsor of a technical meeting The NestlĂŠ Nutrition Institute as co-presenting partner for a workshop The Orentreich Foundation for the Advancement of Science, Inc. as co-presenting partner for a technical meeting Unilever as sponsor of the Research Fund The World Health Organization as copresenting partner of a technical meeting

Malaysian Industry-Government Group for High Technology (MIGHT) as co-presenting partner for a technical meeting and workshop

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The Sackler Institute for Nutrition Science at the New York Academy of Sciences, Annual Report 2016  
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