Pharmaceutical & Cosmetic Review October 2017

Page 41

SLIMMING & BODY CONTOURING How lifestyle affects fat storage Consumers deal with their hectic lifestyles in different ways – some go for a walk, others meditate or exercise. Either way, stressful situations result in the body releasing cortisol. In small amounts, cortisol is a normal and healthy adaptation reflex. However, people who are exposed to a hectic lifestyle will sustain higher levels of cortisol, which negatively affects lipolysis. Codif Laboratories (Codif) has discovered that lipolysis and even caffeine are affected by a busy lifestyle. To combat this negative effect, Codif developed an active ingredient that redefines, In in vivo studies, Codif used 25 active

reshapes and refines the body to restore its original outline. The active is particularly effective

volunteers aged between 35 and 59 with a body

on those who lead hectic lives.

mass index between 20 and 25. They applied a

Figure 2: The effect of B-Shape on HSL

cream containing 1.5 percent Polysiphonia

Slim down with red algae Seaweed has been used for decades for its slimming properties. Through the discovery of a specific seaweed (Polysiphonia brodiei), Codif has been able to increase lipolytic activity due to the stimulation of hormone-sensitive lipase (HSL), reducing lipid droplet associated protein (LDAP).

DID YOU KNOW?

brodiei (B-Shape) on the hips, arms and stomach twice daily for 28 days. Numerical measurements were

Women generally have more taken doing an extraction of cellulite than men. According to the digital profile on the hips ScientificAmerica.com, collagen in and stomach. Centimetre women has the appearance of a picket measurements were also taken fence, whereas in men it looks more on the arms using a measuring like a cross-linked fence. The crosslinked structure is believed to be tape. The results were -8.2 percent much stronger and so it on average and up to -56 percent holds fat in better.

This protein coats and protects lipid

reduction in the width of the hips.

The stomach showed a -5.6 percent on

droplets in adipocytes. HSL is an essential and

average and up to 36 percent reduction. The

indispensable enzyme in the activation process of

arms, -0.3cm on average and up to -1.47cm in

lipolysis. It is expressed in adipose tissue where it

arm circumference.

burns stored triglycerides to free fatty acids. In in vitro studies, 1μM of cortisol (a stress

The species of algae was named Brodiei in honour of James Brodie, a Scottish naturalist.

mediator) was used to model a busy life. Human

This is a common algae in Brittany, native to

adipocytes were then treated with 0.2 percent of

the European coasts from Norway to Portugal.

Polysiphonia brodiei for four hours.

It is a red algae, which grows in tufts of five to

LDAP and HSL were labelled by

25cm. It cultivates itself on rocks, stones, shells

immunofluorescence and quantified. LDAP

A significant reduction in fat nodes was present in the thighs after only 28 days of treatment

or corallines. •

production was reduced by 70 percent and HSL production stimulated by 237 percent, increasing lipolysis even under less hectic conditions:

Vantage South Africa – www.vantagespecialties.com

+64 percent.

P C Review | OCTOBER 2017 |

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