Guided by the National Collaborating Centre of Methods and Tools Rapid Review Guide (Dobbins, 2017), this rapid review seeks to answer the question, “What are the best practices for preventing and mitigating COVID-19 related stigma in Indigenous rural, remote and northern communities within Canada?” The paper synthesizes information from 25 papers that explored stigma mitigation strategies used by Indigenous communities during past infection disease outbreaks and factors that need to be considered when undertaking such strategies within rural, remote, northern and Indigenous contexts.