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Hemopoietic System It consists of 3 organs: 1-Lymph nodes

(Lymphadenitis).

2-Spleen

(Splenitis).

3-Bone Marrow

(Osteomyelitis).

Lymph nodes Lymphadenitis:

inflammation of lymph node (L.n.).

I-Classification of lymphadenitis according to Duration: 1-Acute lymphadenitis

2-Chronic lymphadenitis

II-Classification of lymphadenitis according to Exudate and Lesions: 1-Serous Hemorrhagic

2-Fibrinous

3-Suppurative

4-


Acute Lymphadenitis: Macroscopic Picture:

1-The affected L.n. is enlarged. 2-The affected L.n. is congested. 3-Soft and moist

in

Serous Lymphadenitis.

-Firm

in

Fibrinous Lymphadenitis.

-Pus on cut surface in

Suppurative Lymphadenitis.

-Hemorrhagic (dark red)

Hemorrhagic Lymphadenitis.

-Black wit bad odor in

Gangrenous Lymphadenitis.

-Friable cheesy material

Necrotic Lymphadenitis.

Microscopic Picture: 1-Active hyperemia.

2-leukoctic infiltrations.

3-Hyperplasia of lymphocytes and REC.


4-Edema (Albumin) in

Serous Lymphadenitis.

-Fibrin threads

in

Fibrinous Lymphadenitis.

-RBCs

in

Hemorrhagic Lymphadenitis.

-Neutrophils and pus in

Suppurative Lymphadenitis.

-Loss of cellular details and tissue architecture in Necrotic Lymphadenitis. -Gas bubbles and M.O. in Gangrenous Lymphadenitis.

Chronic Lymphadenitis:

-Follow the acute type -T.B., Johne’s disease, Glanders, Actinobacillosis Macroscopic Picture: 1-L.n. is enlarged 4-Pink in color.

2-Edematous

3-Firm


Microscopic Picture: 1-Fibrous connective tissue proliferation. 2-Hyperplasia of the lymphocytes and REC. 3-Caseation and calcification (TB). 4-Macrophages, epithelioid cells and giant cells infiltration.

Spleen Splenitis: Inflammation of spleen. I-Classification of Splenitis according to Duration: 1-Acute Splenitis (focal or diffuse) 2-Chronic Splenitis II-Classification of Splenitis according to Exudate and Lesions: 3-Suppurative: pyogenic M.O. (pyemia). 4-Hemorrhagic: Septicemic D. (anthrax) or trauma 5-Necrotic: S. necropherous, TB, Brucella 6-Gangrenous: Foreign body with saprophytic M.O.


Splenomegaly: Enlargement of spleen as in case of chronic anemia.

Bone Marrow In Young Animals: the bone marrow present in the shaft of all long bones. In Old Animals:

Red bone marrow present in epiphyses of long bones. Yellow bone marrow present in the shaft.

Gelatinous degeneration of B.M. Causes:

1-Bacterial toxins 2-Chronic debilitating diseases.

Lesions: The yellow and red bone marrow become gelatinous (Jellylike structure).


Anemia:

Decrease the number of RBCs.

Polycythemia:

Increase the number of RBCs.

Leukocytosis:

Increase the number of leukocytes.

Neutrophilia:

Increase the number of neutrophils.

Eosinophilia:

Increase the number of eosinophils.

Lymphocytosis:

Increase the number of lymphocytes.

Monocytosis:

Increase the number of Monocytes.

Leukopenia:

Decrease the number of leukocytes.

Leukemia Definition: It is abnormal increase in the number of leukocytes especially with immature cells. Types of Leukemia: 1-Lymphocytic Leukemia. 2-Myelocytic or Granulocytic Leukemia.


Differences between Lymphocytic and Granulocytic Leukemia

Criterion

Lymphocytic

Myelocytic

Cell-types

Increase lymphocytes lymphoblasts

Increase granulocytes myelocytes myeloblasts

Spleen

Enlarged or not

Enlarged with dark red color and ruptured

L.ns.

Enlarged with grayish red color

Not involved

Bone marrow

Yellowish and grayish (not pinkish)

grayish or pinkish

Liver, kidneys, Lesser affected than lungs the granulocytic

Serous memb.

Focal or diffuse neoplastic swelling, greenish in color, fatty changes in liver

Petechial hemorrhages

Pathology of Hemopoietic system  

pathology of spleen, lymp nodes and bone marrow

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