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Content

Intermediates for APIs

About us Dear Reader,

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Commercial scale products Page 2

evocatal is a specialist in biocatalysis and enzyme technology. Our strong techno‐ logy platforms enable us to offer our chemical and pharmaceutical industry customers the following products and services:

Chiral building blocks ‐ Secondary alcohols

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‐ Diols

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‐ Hydroxyesters

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‐ Hydroxyketones

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‐ Chiral building blocks

‐ other chiral building blocks

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‐ Enzymes / biocatalysts ‐ Enzyme development ‐ Protein expression Furthermore, evocatal develops processes for fermentation and stereoselective synthesis. With our customer services you will benefit from evocatal‘s expertise as a result of many successful years in the commercial sector. This catalog gives you an overview of our evochemicals and potential areas of appli‐ cation.

Contact:

We look forward to receiving your request.

evocatal GmbH Alfred‐Nobel‐Str. 10 40789 Monheim am Rhein, Germany Phone +49 2173 40994‐0 Fax  +49 2173 40994‐40 info@evocatal.com www.evocatal.com

For samples and pricing information please contact: David Hopkins (Business Development) d.hopkins@evocatal.com

HRB‐No. 56230 VAT‐No. DE 250606415 Dr. Thorsten Eggert (Managing Partner) Dr. Michael Puls (Managing Director) 1


Intermediates for APIs Cat. No. 

Structure

Name

Properties

Application / API 

Status

evo‐3.1.201 

evo‐3.1.353

N

OH

evo‐3.1.051  

(R)‐1‐[3,5‐Bis (trifluoromethyl)  phenyl] ethanol 

CAS 127852‐28‐2  C10H8F6O  258.16 g/mol  ee  ≥ 99 % 

Aprepitant

Commercial scale 

(R)‐3‐ Quinuclidinol (free base) 

CAS 25333‐42‐0  C7H13NO  127.19 g/mol  ee  ≥ 98 % 

Solifenacin

Commercial scale 

(R)‐Methyl‐3‐ hydroxybutyrate

CAS 3976‐69‐0 C5H10O3 118.13 g/mol  ee  ≥ 99.5 % 

Dorzolamide

Commercial scale 

(R)‐1‐Phenyl‐2‐ propanol

CAS 1572‐95‐8  C9H12O  136.19 g/mol  ee  ≥ 99 % 

Amphetamine 

Lab scale 

CAS 131‐48‐6  C11H19NO9 309.27 g/mol  [α]D20        ‐32 ± 2° (c=1) 

Zanamivir

Lab scale   

evo‐3.1.191 

HO evo‐3.1.301

OH OH N

COOH O

HO

N‐Acetyl‐

OH neuraminic acid  NANA, Neu5Ac 

O

Commercial scale products Cat. No. 

Structure

Name

Properties

OH evo‐3.1.023

(R,R)‐2,3‐ Butanediol

CAS C4H10O2  ee   de  

24347‐58‐8 90.12 g/mol  ≥ 99.5 %  ≥ 97 % 

Chiral ligand   

(S,S)‐2,3‐ Butanediol 

CAS C4H10O2  ee   de  

19132‐06‐0 90.12 g/mol  ≥ 99.5 %  ≥ 98 % 

Chiral ligand   

(R,R)‐2,5‐ Hexanediol

CAS C6H14O2  ee  de  

17299‐07‐9 118.17 g/mol  ≥ 99 %  ≥ 99 % 

Chiral ligand   

(S,S)‐2,5‐ Hexanediol

CAS C6H14O2  ee  de  

34338‐96‐0 118.17 g/mol  ≥ 99 %  ≥ 99 % 

Chiral ligand   

OH OH evo‐3.1.024

OH evo‐3.1.021

evo‐3.1.022

Application / API 

*Building block for chiral ligand in homogeneous catalysis

2

*

*

*

*


Commercial scale products

Cat. No. 

Structure

Name

Properties

Application / API 

evo‐3.1.201 

(R)‐1‐[3,5‐Bis (trifluoromethyl)  phenyl] ethanol 

CAS 127852‐28‐2  C10H8F6O  258.16 g/mol  ee  ≥ 99 % 

Aprepitant

evo‐3.1.353

(R)‐3‐ Quinuclidinol (free base) 

CAS 25333‐42‐0  C7H13NO  127.19 g/mol  ee  ≥ 98 % 

Solifenacin

(R)‐Methyl‐3‐ hydroxybutyrate

CAS 3976‐69‐0  C5H10O3  118.13 g/mol  ee  ≥ 99.5 % 

Dorzolamide

(S)‐Methyl‐3‐ hydroxybutyrate

CAS 53562‐86‐0  C5H10O3  118.13 g/mol  ee  ≥ 99.5 % 

Building block 

(R)‐Ethyl‐3‐ hydroxybutyrate

CAS 24915‐95‐5  C6H12O3  132.16 g/mol  ee  ≥ 99.5 % 

Building block 

(S)‐Ethyl‐3‐ hydroxybutyrate 

CAS 56816‐01‐4  C6H12O3  132.16 g/mol  ee  ≥ 99.5 % 

Building block 

(R)‐1‐Phenyl‐ ethanol

CAS C8H10O  ee 

1517‐69‐7 122.16 g/mol  ≥ 99.5 % 

Building block 

(S)‐1‐Phenyl‐ ethanol

CAS C8H10O  ee 

1445‐91‐6 122.16 g/mol  ≥ 99.5 % 

Building block 

(S)‐2‐Octanol

CAS C8H18O  ee 

N

OH

evo‐3.1.051  

evo‐3.1.052   evo‐3.1.071    evo‐3.1.072   

evo‐3.1.061

OH evo‐3.1.062

evo‐3.1.122    

3

6169‐06‐8 130.23 g/mol  ≥ 99 % 

Liquid crystal  manufacture 


Chiral building blocks Secondary alcohols Cat. No. 

Structure

Name

evo‐3.1.011

31087‐44‐2 88.15 g/mol  ≥ 99.5 % 

Building block 

Lab scale 

(S)‐2‐Pentanol

CAS C5H12O  ee 

26184‐62‐3 88.15 g/mol  ≥ 99.5 % 

Building block 

Lab scale 

(R)‐2‐Hexanol

CAS C6H14O  ee 

26549‐24‐6 102.18 g/mol  ≥ 99 % 

Building block 

Lab scale 

(S)‐2‐Hexanol

CAS C6H14O  ee 

52019‐78‐0 102.18 g/mol  ≥ 99 % 

Building block 

Lab scale 

(R)‐2‐Octanol

CAS C8H18O  ee 

5978‐70‐1 130.23 g/mol  ≥ 99 % 

Building block 

Lab scale 

(S)‐2‐Octanol

CAS C8H18O  ee 

6169‐06‐8 130.23 g/mol  ≥ 99 % 

Liquid crystal  manufacture 

Commercial   scale 

(R)‐6‐Methyl‐5‐ hepten‐2‐ol

CAS C8H16O  ee 

58917‐27‐4 128.21 g/mol  ≥ 94 % 

(R)‐Sulcatol

Lab scale 

(S)‐6‐Methyl‐5‐ hepten‐2‐ol

CAS C8H16O  ee 

58917‐26‐3 128.21 g/mol  ≥ 99 %   

(S)‐Sulcatol

Lab scale 

(R)‐3‐ Quinuclidinol (free base) 

CAS C7H13NO  ee 

25333‐42‐0 127.19 g/mol  ≥ 98 % 

Solifenacin

Commercial   scale 

(R)‐3‐ Quinuclidinol hydrochloride 

CAS 42437‐96‐7  C7H13NO x HCl  163,65 g/mol  ee  ≥ 98 % 

Solifenacin

Lab scale 

evo‐3.1.112  

evo‐3.1.121  

evo‐3.1.122     evo‐3.1.181 

evo‐3.1.182

evo‐3.1.353

evo‐3.1.351

N

N

OH

OH

x HCl

Status

CAS C5H12O  ee 

evo‐3.1.111

Application   / API 

(R)‐2‐Pentanol  

evo‐3.1.012

Properties

4


Chiral building blocks Secondary alcohols cont. Cat. No. 

Structure

Name

Properties

Application

Status

evo‐3.1.061

(R)‐1‐Phenyl‐ ethanol

CAS C8H10O  ee 

1517‐69‐7 122.16 g/mol  ≥ 99.5 % 

Building block 

Commercial   scale 

(S)‐1‐Phenyl‐ ethanol

CAS C8H10O  ee 

1445‐91‐6 122.16 g/mol  ≥ 99.5 % 

Building block 

Commercial scale 

(R)‐1‐(2‐Chloro‐ phenyl) ethanol   

CAS C8H9ClO  ee 

120466‐66‐2 156.61 g/mol  ≥ 94%  

Building block 

Lab scale 

(S)‐1‐(2‐Chloro‐ phenyl) ethanol   

CAS C8H9ClO  ee 

131864‐71‐6 156.61 g/mol  ≥ 99% 

Building block 

Lab scale 

(R)‐1‐(3‐Chloro‐ phenyl) ethanol 

CAS C8H9ClO  ee 

120121‐01‐9 156.61 g/mol  ≥ 99 % 

Building block 

Lab scale 

(R)‐1‐(4‐Chloro‐ phenyl) ethanol 

CAS C8H9ClO  ee 

75968‐40‐0 156.61 g/mol  ≥ 99 % 

Building block 

Lab scale 

(S)‐1‐(4‐Chloro‐ phenyl) ethanol 

CAS C8H9ClO  ee 

99528‐42‐4 156.61 g/mol   ≥ 99 % 

Building block 

Lab scale 

OH

evo‐3.1.062

OH

Cl

evo‐3.1.211

OH

Cl

evo‐3.1.212

OH evo‐3.1.093

Cl

OH

evo‐3.1.091

Cl OH

evo‐3.1.092

Cl

www.evocatal.com 5


Chiral building blocks Secondary alcohols cont. Cat. No. 

Structure

Name

Properties

Application

Status

evo‐3.1.221

(R)‐2‐Chloro‐1‐ phenylethanol

CAS C8H9ClO  ee 

56751‐12‐3 156.61 g/mol  ≥ 99 % 

Building block 

Lab scale 

evo‐3.1.222

(S)‐2‐Chloro‐1‐ phenylethanol

CAS C8H9ClO  ee 

70111‐05‐6 156.61 g/mol  ≥ 99 % 

Building block 

Lab scale 

OH

(R)‐1‐Phenyl‐2‐ propanol

CAS C9H12O  ee  

1572‐95‐8 136.19 g/mol  ≥ 99% 

Amphetamine

Lab scale 

OH

(S)‐1‐Phenyl‐2‐ propanol

CAS C9H12O  ee  

1517‐68‐6 136.19 g/mol  ≥ 99% 

Building block 

Lab scale 

(R)‐1‐(2‐Furyl) ethanol 

CAS C6H8O2  ee 

27948‐61‐4 112.13 g/mol  ≥ 97 % 

Building block 

Lab scale 

CAS C6H8O2  ee 

85828‐09‐7 112.13 g/mol  ≥ 97 % 

Building block 

Lab scale 

evo‐3.1.191 

evo‐3.1.192 

evo‐3.1.101

evo‐3.1.102

(S)‐1‐(2‐Furyl) ethanol 

evo‐3.1.201

(R)‐1‐[3,5‐Bis (trifluoromethyl) phenyl] ethanol 

CAS 127852‐28‐2  C10H8F6O  258.16 g/mol  ee   ≥ 99% 

Aprepitant

Commercial scale 

evo‐3.1.202

(S)‐1‐[3,5‐Bis trifluoromethyl)  phenyl] ethanol 

CAS 225920‐05‐8  C10H8F6O  258.16 g/mol  ee   ≥ 99% 

Building block 

Lab scale 

6


Chiral building blocks Diols Cat. No. 

Structure

Name

Properties

OH evo‐3.1.023

CAS C4H10O2  ee   de  

24347‐58‐8 90.12 g/mol  ≥ 99.5 %  ≥ 97 % 

Chiral ligand   

(S,S)‐2,3‐ Butanediol

CAS C4H10O2  ee   de  

19132‐06‐0 90.12 g/mol  ≥ 99.5 %  ≥ 98 % 

Chiral ligand   

Commercial scale 

(R,R)‐2,4‐ Pentanediol

CAS C5H12O2  ee  de  

42075‐32‐1 104.15 g/mol  ≥ 99.5%  ≥ 99 % 

Building block 

Lab scale 

(S,S)‐2,4‐ Pentanediol

CAS   C5H12O2  ee  de  

72345‐23‐4 104.15 g/mol  ≥ 98.5 %  ≥ 98 % 

Building block 

Lab scale 

(R,R)‐2,5‐ Hexanediol

CAS C6H14O2  ee  de  

17299‐07‐9 118.17 g/mol  ≥ 99 %  ≥ 99 % 

Chiral ligand   

(S,S)‐2,5‐ Hexanediol

CAS C6H14O2  ee  de  

34338‐96‐0 118.17 g/mol  ≥ 99 %  ≥ 99 % 

Chiral ligand   

(R,R)‐3,5‐ Heptanediol

CAS C7H16O2  ee   de  

77291‐90‐8 132.20g/mol  ≥ 99.5 %  ≥ 99 % 

Chiral ligand   

(R,R)‐3,6‐ Octanediol

CAS C8H18O2  ee   de  

129619‐37‐0 146.22 g/mol  ≥ 99 %  ≥ 98 % 

Chiral ligand   

OH OH

OH evo‐3.1.081

evo‐3.1.082

evo‐3.1.021

evo‐3.1.022

evo‐3.1.161

evo‐3.1.171

Status

(R,R)‐2,3‐ Butanediol

evo‐3.1.024

Application

*Building block for chiral ligand in homogeneous catalysis

7

*

*

*

*

Commercial scale 

Commercial scale 

Commercial scale 

*

Lab scale 

*

Lab scale 


Chiral building blocks Hydroxyesters Cat. No. 

Structure

Name

evo‐3.1.051  

evo‐3.1.052  

evo‐3.1.071  

evo‐3.1.072  

Properties

Application

Scale

(R)‐Methyl‐3‐ hydroxybutyrate

CAS 3976‐69‐0  C5H10O3  118.13 g/mol  ee  ≥ 99.5 % 

Dorzolamide

Commercial scale 

(S)‐Methyl‐3‐ hydroxybutyrate

CAS 53562‐86‐0  C5H10O3  118.13 g/mol  ee  ≥ 99.5 % 

Building block 

Commercial scale 

(R)‐Ethyl‐3‐ hydroxybutyrate

CAS 24915‐95‐5  C6H12O3  132.16 g/mol  ee  ≥ 99.5 % 

Building block 

Commercial scale 

(S)‐Ethyl‐3‐ hydroxybutyrate 

CAS 56816‐01‐4  C6H12O3  132.16 g/mol  ee  ≥ 99.5 % 

Building block 

Commercial scale 

Hydroxyketones Cat. No. 

Structure

Name

Properties

Application

Scale

evo‐3.1.251

(R)‐2‐Hydroxy‐1‐ phenyl‐1‐ propanone

CAS 65646‐06‐2  C9H12O2  150.17 g/mol  ee  ≥ 98 % 

Building block 

Lab scale 

(R)‐2‐Hydroxy‐ 3,3‐dimethoxy‐1‐ phenyl‐1‐ propanone

CAS 569351‐80‐0  C11H14O4 210.22 g/mol ee  ≥ 98 % 

Building block 

Lab scale 

(R)‐Benzoin

CAS 5928‐66‐5  C14H12O2 212.24 g/mol ee  ≥ 99 % 

Building block 

Lab scale 

(S)‐Benzoin

CAS 5928‐67‐6  C14H12O2 212.24 g/mol ee  ≥ 95 % 

Building block 

Lab scale 

evo‐3.1.261

evo‐3.1.151

evo‐3.1.152

 

8


Chiral building blocks Other chiral building blocks

Cat. No. 

Structure

evo‐3.1.291

evo‐3.1.292

evo‐3.1.301

 

Name

Properties

Application

Scale

(R)‐2‐Phenyloxirane (R)‐Styrene Oxide 

CAS C8H8O  ee  

20780‐53‐4   120.15  g/mol  ≥ 99 % 

Building block 

Lab Scale 

(S)‐2‐Phenyloxirane (S)‐Styrene Oxide 

CAS C8H8O  ee  

20780‐54‐5   120.15 g /mol  ≥ 99 % 

Building block 

Lab Scale 

N‐Acetyl‐neuraminic acid, NANA, Neu5Ac 

CAS 131‐48‐6  C11H19NO9309.27 g/mol  [α]D20         ‐32 ± 2° (c=1)  

Zanamivir

Lab Scale 

If you have any questions concerning quantities or delivery times, please contact : evocatal GmbH Alfred‐Nobel‐Str. 10 40789 Monheim am Rhein, Germany Phone +49 2173 40994‐0 Fax  +49 2173 40994‐40 info@evocatal.com www.evocatal.com

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Contact: Dr. Michael Puls (Managing Director) Mr. David Hopkins (Business Development) evocatal GmbH Alfred‐Nobel‐Str. 10 40789 Monheim am Rhein, Germany Phone +49 2173 40994‐0 Fax  +49 2173‐40994‐40 info@evocatal.com www.evocatal.com

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Catalog of Fine Chemicals 2014

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