Wake Up Stroke and Mismatch Anthony J Furlan MD Gilbert Humphrey Professor Chairman Department of Neurology Co-Director Neurological Institute University Hospitals Case Medical Center Case Western Reserve University School of Medicine ATLANTIS/ECASS/NINDS mRS 0-1 at Day 90 ECASSIII Lancet. 2004 tPA = tissue plasminogen activator 80% of stroke patients arrive > 3 hours from onset UCLA Stroke Center