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BT 1358 | 2013

PROTEIN ENGINEERING MARKET [Products (Monoclonal Antibody, Insulin Analog, Modified EPO), Technology (Sequential Modification, Glycosylation, PEGylation), and Applications (Therapeutics, Diagnostics, Research)] -

Global Forecast To 2017 Report Description Ta b l e o f C o n t e n t s L i s t o f Ta b l e s About Markets and Markets Related Reports

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BT 1358 | 2013

Protein Engineering Market - Global Forecast To 2017

Report Description Key Take-Aways •

Analysis of current and emerging technologies in the global protein engineering market

Definition, measurement, and forecast of the global protein engineering market

Analysis of the global protein engineering market by geography, technology, products, and applications

Region-wise analysis of the market based on products

Growth impact analysis with drivers and restraints, and their impact for a five-year timeline

Assumption Particulars

Protein Engineering Market

Description • The market for protein engineering is calculated based on sale of products, which are derived using hybrid protein technologies ( eg. fusion proteins (Rilonacept)), PEGylated proteins, second generation proteins derived through engineering of first generation proteins (for eg. insulin analogs, Monoclonal antibodies and second generation Erythropoietin). This report does not include first generation recombinant proteins that were merely derived using recombinant technology for market size estimation and forecast. • Diagnostics market segment is derived majorly based on the use of monoclonal antibodies for diagnostic applications. • Market for engineered proteins for research applications is assumed to account only 0.25% of the total market.

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BT 1358 | 2013

Protein Engineering Market - Global Forecast To 2017

Report Description Research Methodology

Regional Market share

Description • Regional market share is derived based on the present market scenario and sale of products in the region. Despite stringent FDA regulations North America is assumed to grow at a faster rate compared to Europe which has been known for faster product approvals compared to any other market. Asia is assumed to grow at a higher rate because of changing economic conditions and growing demand for bio-therapeutics. • Population of diabetes and cancer incidence rates are derived based on incidence per 100,000.

General Assumption

• It is assumed that the market is expected to have a normal growth as there are no significant changes expected in the market scenario and regulatory landscape during the forecasted period.

Report Description This technology report gives a brief description of protein engineering technologies, recent trends, and future development. It also covers protein product systems, their advantages and upcoming trends. Technologies that are analyzed in the report include Sequence Modification/Glycosylation, PEGylation, display technologies, humanization technologies, hybrid technologies, and transgenic mice. The market has been categorized by geography, application, products and technology. Forecast has been made by analyzing current and future trends in therapeutic and diagnostics applications. The protein engineering market is segmented on the basis of its application into

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therapeutics, diagnostics, and research application. Product segments are classified as monoclonal antibodies, Insulin analogs, EPO, other proteins, diagnostics, and research applications. Further geographic segmentation is done based on products and markets for monoclonal antibodies (therapeutic condition). An impact analysis of major drivers and restraints influencing the adoption and growth of the market during from 2012 to 2017 has also been obtained. Major countries’ market potential and current development in the region is discussed to give a brief idea on potential adoption and growth of the industry. Competitive landscape, strategies adopted, and proprietary platform technologies of companies are discussed briefly.

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BT 1358 | 2013

Protein Engineering Market - Global Forecast To 2017

Report Description Research Methodology RESEARCH PROCESS

Secondary Research

Primary Research Universities, Doctors, CRO’s, CMO’s & Companies

Technology Journals

Market Research Reports

Discussion Guide/ Questionnaire Preparation

Secondary Sources

Data Points, Trends & Strategy

Technology Information websites

E-mail & Telephonic Interviews §Generating Insights

Internal Databases

§Key Findings

Primary Primary Sources Sources

M&M M&M Consultants

Consultants

Online Surveys

§Market Forecasts Thought Leader Briefings

DATA TRIANGULATION

Data Validation

PDF Format (End Deliverable)

Note: *Target Sample - Research Scientists/Professors, CEOs/CSOs, Research and Product Development officers, Strategic Decision Makers, Technology Policy Heads

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BT 1358 | 2013

Protein Engineering Market - Global Forecast To 2017

Report Description Key Data Points from Primary and Secondary Sources Data Points from Secondary Sources •

Protein engineering technologies

Product and revenue details of companies

Mergers, acquisitions, new product developments and investment deals

Market revenue trends and market dynamics

Data Points from Primary Sources •

Market shares of different technologies

Recommendation of strategies

Region-wise growth rate and market shares

Verification of secondary data

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BT 1358 | 2013

Protein Engineering Market - Global Forecast To 2017

Table of Contents 1. Introduction

.....................................................................................................................................................................18-23

1.1

Key Take- Aways

1.2

Report Scope

1.3

Report Segmentation

1.4

Research Methodology

1.5

Key Data Points from Primary and Secondary Sources

2. Executive Summary................................................................................................................................................................24-27

3. Protein Engineering Technologies – Landscape Analysis.................................................................................................28-45 3.1

Technology - Introduction

3.2

Technology – Evolution

3.3

Market Segmentation

3.4

Protein and Antibody Engineering Technologies – Overview

3.4.1

Sequence Modification

3.4.2

Glycosylation

3.4.3

Pegylation

3.4.4

Display Technologies

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BT 1358 | 2013

Protein Engineering Market - Global Forecast To 2017

Table of Contents 3.4.5

Humanization technology

3.4.6

Hybrid technology

3.4.7

Production systems

3.4.8

Mapping of protein production systems

3.4.9

Emerging production systems

3.5

Protein Engineering – Technology Value Chain Analysis

4. Applications 4.1

....................................................................................................................................................................46 - 54

Therapeutic Development – Overview

4.1.1

Insulin analogs

4.1.2

Monoclonal antibodies

4.1.3

Therapeutic development - erythropoietin & others

4.2

Diagnostics

4.3

Research – Meganuclease Engineering/ZFP & TALENS Engineering

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BT 1358 | 2013

Protein Engineering Market - Global Forecast To 2017

Table of Contents 5. Market Landscape Analysis.................................................................................................................................................55-92 5.1

Global Protein Engineering Market Forecast

5.1.1

Introduction

5.1.2

Global protein engineering market forecast, by geography

5.1.3

Global protein engineering market forecast, by product

5.1.4

Global protein engineering market forecast, by application

5.1.5

Global protein engineering market forecast, by technology

5.2

Market Dynamics - Overview

5.2.1

Drivers – description

5.2.2

Drivers’ impact – timeline

5.2.3

Restraints – description

5.2.4

Restraints impact – timeline

5.2.5

Opportunities – description

5.2.6

Threats – description

5.2.7

Pestle analysis

5.3

Market Segmentation, by Product

5.3.1

Insulin analogs

5.3.1.1 Insulin analog market 5.3.1.2 Insulin analog market, by geography

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BT 1358 | 2013

Protein Engineering Market - Global Forecast To 2017

Table of Contents 5.3.1.3 Market share analysis 5.3.2

Modified EPO

5.3.2.1 Modified EPO market 5.3.2.2 Modified EPO market, by geography 5.3.3

Monoclonal antibodies (mAb)

5.3.3.1 Monoclonal antibodies market 5.3.3.2 Monoclonal antibodies market, by geography 5.3.3.3 Monoclonal antibodies market, by application 5.3.3.4 Major products in the market 5.4

Other Proteins

5.4.1

Other proteins market

5.4.2

Other proteins market, by geography

5.4.3

Diagnostic proteins, by geography

6. Geographic Analysis .............................................................................................................................................................114-118 6.1

North America

6.2

Europe

6.3

Asia

6.4

RoW

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BT 1358 | 2013

Protein Engineering Market - Global Forecast To 2017

Table of Contents 7. Technology And Product Portfolio .......................................................................................................................................101-105 7.1

Proprietary Technology Platforms

7.2

Product Pipeline Analysis of Key Players

8. Competitive Landscape ......................................................................................................................................................106 - 111 8.1

Introduction

8.2

Porter’s Five Force Analysis

8.3

Mergers & Acquisitions, 2009 – 2012

8.4

Partnerships & Collaborations, 2012 - 2013

8.5

New Product Launch, 2010 – 2012

9. Analyst Insights and Recommendation ............................................................................................................................112 - 114 9.1

Strategic Recommendations

10. Company Profiles ................................................................................................................................................................115 - 146 (Overview, financials, products & services, strategy, and developments) 10.1 Genentech, Inc. 10.2 Amgen, Inc.

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BT 1358 | 2013

Protein Engineering Market - Global Forecast To 2017

Table of Contents 10.3 Biogen Idec, Inc. 10.4 Novartis AG 10.5 Glaxo Smithkline Plc 10.6 Eli Lilly & Co 10.7 Bristol Myers Squibb Co. 10.8 Johnson & Johnson 10.9 Merck & Co., Inc. 10.10 Sanofi 10.11 Pfizer, Inc. 10.12 Regeneron Pharmaceuticals, Inc. 10.13 Eleven Biotherapeutics (U.S.) 10.14 ToolGen, Inc. (Korea) 10.15 DNA2.0, Inc. (U.S.) 10.16 AvidBiotics Corp. (U.S.) 10.17 Sigma-Aldrich Corp. (U.S.) 10.18 Xencor Inc. 10.19 Morphosys *Details on Financials, Product & Services, Strategy, & Developments might not be captured in case of unlisted companies.

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BT 1358 | 2013

Protein Engineering Market - Global Forecast To 2017

List of Tables Table Titles ............................................................................................................................................................Page No 1

Global Protein Engineering Market Revenue, 2012 - 2017 ($Billion)

57

2

Global Protein Engineering Market, by Geography, 2012 - 2017 ($Billion)

58

3

Global Protein Engineering Market, by Product, 2012 - 2017 ($Billion)

60

4

Global Protein Engineering Market, by Application, 2012 - 2017 ($Billion)

62

5

Global Protein Engineering Market, by Technology, 2012 - 2017 ($Billion)

64

6

Insulin Analogs Market, by Geography, 2012 - 2017 ($Billion)

76

7

Modified EPO Market, by Geography, 2012 - 2017 ($Billion)

80

8

mAb Market, by Geography, 2012 - 2017 ($Billion)

83

9

mAb Market, by Application, 2012 - 2017 ($Billion)

85

10

Other Proteins Market, by Geography, 2012 - 2017 ($Billion)

89

11

Diagnostic Proteins Market, by Geography, 2012 - 2017 ($Billion)

91

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BT 1358 | 2013

Protein Engineering Market - Global Forecast To 2017

List of Figures Figure Titles ..........................................................................................................................................................Page No 1

Global Protein Engineering Market, 2012 - 2017 ($Billion)

25

2

Global Protein Engineering Market, 2012 - 2017 ($Billion)

56

3

Global Protein Engineering Market, by Geography, 2012 (%)

58

4

Growth Rate, by Geography, 2012 - 2017

58

5

Global Protein Engineering Market by Geography, 2012 - 2017 ($Billion)

59

6

Global Protein Engineering Market, by Product, 2012 (%)

60

7

Growth Rate, by Product, 2012 - 2017

60

8

Global Protein Engineering Market, by Product, 2012 - 2017 ($Billion)

61

9

Global Protein Engineering Market, by Application, 2012 (%)

62

10

Growth Rate, by Application, 2012 - 2017

62

11

Global Protein Engineering Market, by Application, 2012 - 2017 ($billion)

63

12

Global Protein Engineering Market, by Technology, 2012 (%)

64

13

Growth Rate, by Technology, 2012 - 2017

64

14

Global Protein Engineering Market, by Technology, 2012 - 2017 ($Billion)

65

15

Market Share Analysis

75

16

Insulin Analogs Market, by Geography, 2012

76

17

Insulin Analogs Market, by Geography, 2012 - 2017 ($Billion)

77

18

Market Share Analysis, Key Players, 2012

78

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BT 1358 | 2013

Protein Engineering Market - Global Forecast To 2017

List of Figures Figure Titles ..........................................................................................................................................................Page No 19

Market Share Analysis of EPO, by Product, 2012

79

20

Modified EPO Market, by Geography, 2012

80

21

Modified EPO Market, by Geography, 2012 - 2017 ($Billion)

81

22

Market Share Analysis of Engineered Therapeutic Proteins, by Product, 2012

82

23

mAb Market, by Geography, 2012

83

24

mAb Market, by Geography, 2012 - 2017 ($Billion)

84

25

mAb Market,by Application, 2012

85

26

mAb Market, by Application, 2012 - 2017 ($Billion)

86

27

Market Share Analysis of Other Proteins, 2012

88

28

Other Proteins Market, by Geography, 2012

89

29

Other Proteins Market, by Geography, 2012 - 2017 ($Billion)

90

30

Diagnostic Proteins Market, by Geography, 2012

91

31

Diagnostic Proteins Market, by Geography, 2012 - 2017 ($Billion)

92

32

Product Pipeline of Key Players

105

33

Growth Strategies

107

34

Amgen, Inc., Total Revenue

119

35

Biogen Idec, Inc., Total Revenue

121

36

Novartis AG, Total Revenue

123

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BT 1358 | 2013

Protein Engineering Market - Global Forecast To 2017

List of Figures Figure Titles ..........................................................................................................................................................Page No 37

Glaxo Smithkline Plc, Total Revenue

125

38

Eli Lilly & Co., Total Revenue

127

39

Bristol Myers Squibb Co., Total Revenue

129

40

Johnson & Johnson , Total Revenue

131

41

Merck & Co., Inc., Total Revenue

133

42

Sanofi , Total Revenue

135

43

Pfizer, Inc., Total Revenue

137

44

Regeneron Pharmaceuticals, Inc., Total Revenue

139

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BT 1358 | 2013

Protein Engineering Market - Global Forecast To 2017

Disclaimer MarketsandMarkets strategic analysis services are limited publications containing valuable market information provided to a select group of customers in response to orders. Our customers acknowledge when ordering that MarketsandMarkets strategic analysis services are for our customers’ internal use and not for general publication or disclosure to third parties. Quantitative market information is based primarily on interviews and therefore, is subject to fluctuation. MarketsandMarkets takes no responsibility for any incorrect information supplied to us by manufacturers or users. No part of this strategic analysis service may be given, lent, resold or disclosed to non-customers without written permission. Furthermore, no part may be reproduced, stored in a retrieval system or transmitted in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, without the permission of the publisher. For information regarding permission, contact: Tel: 1-888-600-6441 Email: sales@marketsandmarkets.com

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BT 1358 | 2013

Protein Engineering Market - Global Forecast To 2017

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BT 1358 | 2013

Protein Engineering Market - Global Forecast To 2017

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Protein Engineering Market worth $168 Billion - 2017  

[No of Slides - 140] Protein Engineering Market report categorizes the global market by products (Monoclonal Antibodies, Insulin Analog, Mod...