3. Distribution of acetic/ benzoic acid between water and cyclohexane. 4. Study the equilibrium of following reaction by the distribution method: Cu2+(aq) + nNH3 → Cu(NH3)n 5. Study the kinetics of acid hydrolysis of methyl acetate with hydrochloric acid 1. Initial rate method: Iodide-persulphate reaction. 6. Study the kinetics of Saponification of ethyl acetate. 7. Compare the strengths of HCl and H2SO4 by studying kinetics of hydrolysis of methyl acetate. 8. Verify the Freundlich and Langmuir isotherms for adsorption of acetic acid on activated charcoal. Course Title/ Code Course Type Course Nature L-T-P-O Structure
Objectives
Organic Chemistry-II (CHH218) T & P Domain Core Hard (3-1-2-0) 1. To familiarize the students about Halogenated Hydrocarbons, alcohols, phenols, ethers and epoxides 2. To make the students understand the chemistry of polynuclear Hydrocarbons 3. To educate the students about carbonyl compounds
ORGANIC CHEMISTRY II-THEORY (CHH218-T) SECTION A CHEMISTRY OF HALOGENATED HYDROCARBONS Alkyl halides: Methods of preparation, nucleophilic substitution reactions, mechanisms with stereochemical aspects and effect of solvent, etc.; nucleophilic substitution vs. elimination. Aryl halides: Preparation including preparation from diazonium salts, nucleophilic aromatic substitution; SNAr, Benzyne mechanism. Relative reactivity of alkyl, allyl/ benzyl, vinyl and aryl halides towards nucleophilic substitution reactions. SECTION B ALCOHOLS, PHENOLS, ETHERS and EPOXIDES Alcohols: Preparation, properties and relative reactivity of 1◦, 2◦, 3◦ alcohols, Bouvael-Blanc Reduction, Preparation and properties of glycols; Oxidation by periodic acid and lead tetraacetate, Pinacol-Pinacolone rearrangement; Phenols: Preparation and properties, Acidity and factors effecting it, Ring substitution reactions, Reimer Tiemann and Kolbe’s Schmidt Reactions, Fries and Claisen rearrangements with mechanism. Ethers and Epoxides: Preparation and reactions with acids. Reactions of epoxides with alcohols, ammonia derivatives and LiAlH4. SECTION C POLYNUCLEAR HYDROCARBONS Polynuclear hydrocarbon or fused ring hydrocarbons: nomenclature Napthalene: structure, synthesis, properties (physical and chemical: sufonation, acylation, nitration, halogenation, reduction, oxidation) and uses(naphthol, naphthylamines) Anthracene: structure, synthesis, properties (physical and chemical: sufonation, nitration, halogenation, reduction, oxidation) and uses (Anthraquinone, Alizarine). Phenanthrene: structure, synthesis, properties (physical and chemical: nitration, acylation) and uses. SECTION D CARBONYL COMPOUNDS Structure, reactivity and preparation; Nucleophilic additions, Nucleophilic addition-elimination 46