What is Asthma ? and Causes of Asthuma Asthma is heterogeneous, recurrent and episodic disease. It is characterized as bronchospasm resulting from bronchoconstriction in response to various stimuli. The inciting agents include pollen, pollution, various food stuff, medications and most commonly allergens. The basis of asthma is bronchial inflammation of the airway. Symptoms of asthma are episodic dyspnea, cough, chest tightness and wheezing. Asthma is chronic bronchial inflammatory disease manifested by primary and secondary mediators. Primary mediators comprise leukotrienes C4, D4, E4, Prostaglandins D2, E2, F2Îą, histamine, platelet activating factor, mast cell tryptase and secondary mediators be eosinophilic and neutrophilic chemotactic factors, leukotriene B4, Interleukins and tumor necrosis factor. Asthmatic attacks last from one hour to several hours and may be several days. Status asthmaticus is prolonged asthma that may lead to death of the patient.
Historical context First case with asthmatic symptoms came about 2500 years ago. Asthma is believed to have Greek origin, ancient Egyptian civilizations also shown firm evidence. Cappadocia mentioned several treatments for asthma Egyptian also played there role in formulating about 700 remedies for asthma. Maimonides wrote Treatise of Asthma written by Moses Maimonides revealed symptoms like common cold during the wet months. Bernardino Ramazzini recognized exercise-induced asthma. During the 1930s to 1950s.Before 20th century asthma was determined as an inflammatory disease.
Prevalence of asthma Asthma is becoming unstoppable entity now days. Worldwide 300 million people of all ages have gone through asthma. The prevalence donâ€™t depend modernization rather in developed the rates are high. The spread of Asthma varies country to country. From the last tow decadeâ€™s number of asthmatics patients grown to be doubled. Worldwide people are spending a great part of their income annually for treatment of asthma.
Statistically, the prevalence of asthma is high in countries like United States, England, Australia, New Zealand, Canada and Germany. Rapidly changing life styles and urbanization are the tow major contributors of high prevalence of asthma. Apart of the modernization spread of asthma spar canâ€™t be controlled. Children Asthmatic patients are more as compared to adults. In children less than 4 years of age asthmatic rate has increased to 14 folds and between 5-14 years of age increased about 7 folds. Asthma is appearing to be the disease of children and older people groups. Older Australians aged 45 years and over, 92% of the deaths were reported in 2006. Death rates are higher in African Americans as compared to general Americans. Current mortality rate in United States is 2.1 per 100,000.
Conclusion Doctors and scientists are working very hard to eradicate asthma globally. Usually therapy consists of bronchodilators and corticosteroids but newer drugs and way of treatment are resulting fruitful solution for as asthma but alarming conditions till remains. Goal of therapy is to prevent recurrence of asthmatic attack deaths due to asthma are because of severe episodes of bronchoconstriction causing shortness of death wheezing and chest tightness. There is no universally accepted simple classification of asthma. A common classification based on the duration of therapy of asthma is: short-term relievers and long-term controllers. Asthma is chronically affecting diseases of childhood, but it affects other age group too. Patient having asthmatic history in their family should be more conscious and IgE immunoglobulin levels in the blood should be checked periodically. Do you often wonder why you miss out on all the fun events while your friends make the most of it? How come they get to have all the excitement in college life while you ruin your sleep
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