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The Benefits Of Preimplantation Genetic Screening Preimplantation genetic screening has many benefits for couples who depend on in vitro fertilization (IVF) as their only means of having children by natural childbirth. The IVF procedure is expensive and successful results of pregnancy are often not obtained except after several trials. Preimplantation genetic screening offers the best opportunity for a successful pregnancy. IVF is often necessary because a woman experiences several sequential miscarriages. This is often due to a number of different chromosomal abnormalities present in the embryo which often result in first trimester miscarriages. Preimplantation genetic screening is not a required procedure, but it is often a chosen additional test performed on in vitro fertilized embryos just for the benefits it provides. With the embryos already available, it is a simple matter of testing, which occupies about four hours to obtain results. One of the primary benefits of preimplantation genetic screening is the opportunity to identify chromosomal abnormalities and screen for the diseases that often result from these abnormalities. If one group of embryos test positive for abnormalities, another group may not and the choice for implantation would come from the negative test result group. There are other indicators that often result in miscarriages. Preimplantation genetic screening can positively identify these markers as well, offering similar benefit as identification of chromosomal abnormalities. There are also certain genetic markers that occur in several genes simultaneously that identify increased chances that either a dominant or recessive genetic disorder may present the potential for a disease either congenitally, or later in the life of the child. This is not the same as diagnosis of a disease, because the genetic marker is not a virtual guarantee that the disease will ever present, but it does offer a greater than average change that the child may develop the disease in childhood or later in life. A variation of the above benefit is the identification of monogenetic disorders, that is, diseases that are derived from the abnormality of a single gene. For young women who have been unable to become pregnant naturally, or have repeatedly failed by in vitro fertilization, the attempt with preimplantation genetic screening improves the opportunity to identify embryos that have the greatest chance to achieve a successful pregnancy. It is not a guarantee, but it offers a greater probability that pregnancy will be successful. Women in excess of 35 years of age, when the rate successful natural pregnancy begins to decline, are not offered any greater probability of pregnancy with preimplantation genetic screening. Some parents who have successfully given birth to a child by natural means may wish to use IVF and additionally opt for preimplantation genetic screening for the purpose of human leukocyte


antigen (HLA) testing, which is one specific screening option and benefit. The benefit is that the resulting IVF child is HLA-matched to a sibling to allow donation should a matched sibling require non-life threatening tissue donation from the HLA-matched IVF child donor. A prime example of this feasibility is the onset of leukemia in a sibling, which can be a life-saving donation for the sibling while incurring no danger for the donor sibling. For many would-be parents, these benefits far exceed the cost and difficulty of IVF and preimplantation genetic screening.

The benefits of preimplantation genetic screening  

Preimplantation genetic screening has many benefits for couples who depend on in vitro fertilization (IVF) as their only means of having chi...

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