a
a
b
b
c
c
Fig. 4. PCNA immunostaining in rats with NTS-induced crescentic glomerulonephritis and post-NTS irradiated-kidneys. a Con-
trol rat kidney, showing a few PCNA-positive cells in the glomerular tufts and interstitium. b 14 days after NTS injection (NTS14d of Group II), showing many PCNA-positive cells in the glomerular tufts and tubulointerstitium. c At day 1 post-irradiation, in rats irradiated at day 13 after NTS injection (NTS14dRa1d of Group III). Note the marked reduction of PCNA-positive cells in the glomerular tufts and interstitium compared with NTS14d of Group II. Orig. magnif. !132.
Radiotherapy and Progression of Crescentic Glomerulonephritis
Fig. 5. Immunostaining of ED1 macrophages in rats with NTS-
induced crescentic glomerulonephritis and post-NTS irradiatedkidneys. a Control rat kidney. Note the lack of ED1-positive cells. b 14 days after NTS injection (NTS14d of Group II). Note the presence of numerous ED1-positive macrophages in the glomerular tufts and tubulointerstitium. c At day 1 post-irradiation, in rats irradiated at day 13 after NTS injection (NTS14dRa1d of Group III), note the marked reduction of the number of ED1-positive macrophages in glomerular tufts and tubulointerstitium compared with NTS14d of Group II. Orig. magnif. !132.
Am J Nephrol 2008;28:555–568
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