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N O V O S T I I Z M E D I C I N S K E L I T E R AT U R E

Uređuje: doc. dr. sc. Dražen Pulanić, dr. med.

PREVENCIJA GASTROINTESTINALNE TOKSIČNOSTI UZROKOVANE NESTEROIDNIM ANTIREUMATICIMA: META-ANALIZA Glede raširenog propisivanja nesteroidnih antireumatika (skr. NSAR) u svijetu, predložene su razne strategije i postupnici kojima bi se prevenirala gastrointestinalna toksičnost uzrokovana tim lijekovima; međutim komparativna učinkovitost pojedinih terapijskih protokola ostaje nejasna. S ciljem istraživanja navedenog problema, kolega Yuan JQ sa suradnicima iz Hong Konga i Kine publicirao je meta-analizu i pregledni članak pretražujući medicinske baze podataka Medline, Embase, i Cochrane Library do svibnja 2015. godine. U meta-analizu su uključena randomizirana, kontrolirana klinička istraživanja, ukupno 82 studije s ukupno 125 053 ispitanika. Cilj istraživanja je bio usporedba rizika za gastrointestinalne nuspojave kod pacijenata koji su liječeni neselektivnim NSAR, selektivnim COX-2 inhibitorima ili neselektivnim NSAR NSARICOX-2 inhibitorima uz gastroprotektivne lijekove (inhibitore protonske crpke (skr. IPC), antagoniste H2-receptora, misoprostol). Rezultati istraživanja su pokazali kako selektivni COX-2 inhibitori u kombinaciji s IPC dovode do ulkusnih komplikacija s omjerom rizika od 0.07 (0.02 -0.17), selektivni COX-2 inhibitori ulkusne komplikacije s omjerom rizika od 0.25 (0.15-0.38), neselektivni NSAR s IPC terapijom ulkusne komplikacije 0.28 (0.18-0.41), a neselektivni NSAR uz misoprostol ulkusne komplikacije 0.47. Dakle, autori zaključuju kako su selektivni COX-2 inhibitori u kombinaciji s IPC povezani s najnižim rizikom za gastrointestinalni incident, potom slijede sami COX­2 inhibitori, a potom NSAR s IPC. (Aliment Pharmacol Ther. 2016 Jun;43(12):1262-75) Ivana Rosenzweig Jukić, dr. med. specijalist interne medicine

LIJEČNIČKE NOVINE 150 06 / 2016

Radovi hrvatskih liječnika objavljeni u inozemnim časopisima indeksiranim u CC, SCI ili SSCI U suradnji s časopisom Croatian Medical Journal donosimo popis recentnih publikacija hrvatskih autora objavljenih u uglednim inozemnim znanstvenim i stručnim medicinskim časopisima indeksiranim u CC, SCI ili SSCI. Sahebkar A, Catena C, Ray KK, Vallejo-Vaz AJ, Reiner Ž*, Sechi LA, Colussi G. Impact of statin therapy on plasma levels of plasminogen activator inhibitor-1. A systematic review and meta-analysis of randomised controlled trials. Thromb Haemost. 2016 Mar 24;116(1). [Epub ahead of print] *University Hospital Center Zagreb and School of Medicine, University of Zagreb, Zagreb, Croatia. De Smedt D, De Bacquer D, De Sutter J, Dallongeville J, Gevaert S, De Backer G, Bruthans J, Kotseva K, Reiner Ž*, Tokgözoğlu L, Clays E. The gender gap in risk factor control: Effects of age and education on the control of cardiovascular risk factors in male and female coronary patients. The EUROASPIRE IV study by the European Society of Cardiology. Int J Cardiol. 2016 Apr 15;209:284-90. *University Hospital Center Zagreb and School of Medicine, University of Zagreb, Zagreb, Croatia. Sahebkar A, Pećin I*, Tedeschi-Reiner E, Derosa G, Maffioli P, Reiner Ž*. Effects of statin therapy on augmentation index as a measure of arterial stiffness: A systematic review and meta-analysis. Int J Cardiol. 2016 Mar 18;212:160-168. doi: 10.1016/j.ijcard.2016.03.010. [Epub ahead of print] *University Hospital Center Zagreb and School of Medicine, University of Zagreb, Zagreb, Croatia. Gregurić T, Trkulja V, Baudoin T, Grgić M, Šmigovec I, Kalogjera L. Differences in the Sino-Nasal Outcome Test 22 and visual analog scale symptom scores in chronic rhinosinusitis with and without nasal polyps. Am J Rhinol Allergy. 2016;30:107-12. Department of Radiology, University Hospital Centre "Sestre Milosrdnice," Zagreb, Croatia. Cerina V1, Kruljac I3, Radosevic JM3, Kirigin LS3, Stipic D1, Pecina HI2, Vrkljan M3. Diagnostic Accuracy of Perioperative Measurement of Basal Anterior Pituitary and Target Gland Hormones in Predicting Adrenal Insufficiency After Pituitary Surgery. Medicine (Baltimore). 2016;95(9):e2898. Department of Neurosurgery, University Hospital Center "Sestre Milosrdnice"; 2Department of Radiology, University Hospital Center "Sestre Milosrdnice"; 3Department of Endocrinology, Diabetes and Metabolic Diseases "Mladen Sekso," University Hospital Center "Sestre Milosrdnice," University of Zagreb Medical School, Zagreb, Croatia. 1

Canecki-Varžić S, Prpić-Križevac I, Bilić-Ćurčić I. Plasminogen activator inhibitor-1 concentrations and bone mineral density in postmenopausal women with type 2 diabetes mellitus. BMC Endocr Disord. 2016;16(1):14. Department of Diabetes, Endocrinology and Metabolism Disorders, University Hospital Center Osijek, Faculty of Medicine, University of Osijek, Osijek, Croatia. Ostojić V. Increased specific immunoglobulin G4 antibodies induced by natural exposure to ambrosia pollen in patients with allergy. Allergy Asthma Proc. 2016;37(2):115-20. Department of Immunology, Allergology and Pulmonology, Clinical Hospital "Sveti Duh," Zagreb, Croatia Baric M1, Sever AZ2, Vuletic LB2, Rasic Z1, Sever M1, Drmic D3, Pavelic-Turudic T4, Sucic M5, Vrcic H4, Seiwerth S2, Sikiric P3. Stable gastric pentadecapeptide BPC 157 heals rectovaginal fistula in rats. Life Sci. 2016;148:63-70. Department of Surgery, School of Medicine, University of Zagreb, Zagreb, Croatia; 2Department of Pathology, School of Medicine, University of Zagreb, Zagreb, Croatia; 3Department of Pharmacology, School of Medicine, University of Zagreb, Zagreb, Croatia; 4Department of Obstetrics & Gynecology, School of Medicine, University of Zagreb, Zagreb, Croatia; 5Department of Urology, School of Medicine, University of Zagreb, Zagreb, Croatia.

1

Bralić Lang V1, Bergman Marković B2. Prevalence of comorbidity in primary care patients with type 2 diabetes and its association with elevated HbA1c: A cross-sectional study in Croatia. Scand J Prim Health Care. 2016;34(1):66-72. Private Family Physician Office affiliated to University of Zagreb, School of Medicine , Zagreb , Croatia; 2Department of Family Medicine , University of Zagreb, School of Medicine , Zagreb , Croatia. 1

Stevanović A, Frančišković T, Vermetten E. Relationship of early life trauma, war related trauma, personality traits and PTSD symptom severity: A retrospective study on female civilian victims of war. Eur J Psychotraumol. 2016;(7):30964. doi: 10.3402/ejpt. v7.30964. Department of Psychiatry and Psychological Medicine, School of Medicine, University of Rijeka, Rijeka, Croatia

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