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TURNING

TYPEONE INTO

TYPENONE IMPROVING LIVES. CURING TYPE 1 DIABETES.


JONATHAN PLATT

AGE 8 “Unlike other kids,

I have to check my blood sugar 8 to 10 times a day; everything I eat is measured and every carbohydrate counted. My kit goes with me everywhere I go … Too much exercise or not eating all my food can be dangerous. I think I’m too young to have to worry about all this stuff.”


“IT CONTROLS YOUR LIFE IN WAYS THAT

SOMEONE WITHOUT IT DOESN’T EVEN SEE...”

OUR

MISSION

- Nicky Hider, New York

JDRF is the leading global organization funding type 1 diabetes (T1D) research. JDRF’s goal is to progressively remove the impact of T1D from people’s lives until we achieve a world without T1D. JDRF collaborates with a wide spectrum of partners and is the only organization with the scientific resources, regulatory influence, and a working plan to better treat, prevent, and eventually cure T1D.


ABOUT

T1D

Type 1 diabetes (T1D) is an autoimmune disease in which a person’s pancreas stops producing insulin, a hormone that enables people to get energy from food. It occurs when the body’s immune system attacks and destroys the insulin-producing cells in the pancreas, called beta cells.

While its causes are not yet entirely understood, scientists believe that both genetic factors and environmental triggers are involved. Its onset has nothing to do with diet or lifestyle. There is nothing you can do to prevent T1D, and—at present — nothing you can do to get rid of it.


We need to be constantly factoring and adjusting, making frequent finger sticks to check blood sugars, and giving ourselves multiple daily insulin injections just to stay alive.� - Mary Tyler Moore

WHOM TD1

EFFECTS Type 1 diabetes strikes both children and adults at any age. It comes on suddenly, causes dependence on injected or pumped insulin for life, and carries the constant threat of devastating complications.


Warning signs of T1D may occur suddenly and can include: •

Extreme thirst

Frequent urination

Drowsiness or lethargy

Increased appetite

Sudden weight loss

Sudden vision changes

Sugar in the urine

Fruity odor on the breath

Heavy or labored breathing

Stupor or unconsciousness

WARNING

FYI

While insulin injections or infusion allow a person with T1D to stay alive, they do not cure the disease, nor do they necessarily prevent the possibility of the disease’s serious effects, which may include: kidney failure, blindness, nerve damage, heart attack, stroke, and pregnancy complications.


HOW T1D IS

MANAGED Living with T1D is a constant challenge. People with the disease must carefully balance insulin doses (either by injections multiple times a day or continuous infusion through a pump) with eating and other activities throughout the day and night. They must also measure their bloodglucose level by pricking their fingers for blood six or more times a day. Despite this constant attention, people with T1D still run the risk of dangerous high or low blood-glucose levels, both of which can be life threatening. People with T1D overcome these challenges on a daily basis.


THE

RATE TD1AMONG CHILDREN UNDERAGE OF

EACHYEAR

MORETHAN 15,000CHILDREN &15,000ADULTS

[PERDAY] APPROXIMATELY

80PEOPLE

DIAGNOSED

ARE

AS

MANY AS3MILLION AMERICANS HAVET1D

14INCREASE ISESTIMATED TO BY

3%ANUALY

WORLDWIDE

WITHT1D


THE

PREVALENCE IN

OF

HEALTHCARE COSTS T1D U.S.EACHYEAR THE

IN

IS

OF

APPROXIMATELY

14.9 BILLION

DOLLARS

T1DPEOPLE

UNDER

AGE 20 INCREASED

23%

BETWEEN 2001&2009

DIABETES

6TH LEADING

IS THE

CAUSE

DEATH

OF

INTHE

UNITEDSTATES


MID-TERM RESEARCH

GOALS

JDRF’s near- to mid-term goals include delivering: •

An automated low-glucose suspend artificial pancreas system, which predicts and prevents severe blood-glucose lows. A treat-to-range artificial pancreas system, which automatically keeps blood-glucose levels in a specified range. The use of existing type 2 diabetes drugs to improve bloodglucose control in people with T1D compared to the use of insulin alone. The use of donated human islets as a treatment for low–blood glucose unawareness.


LONG-TERM RESEARCH

GOALS

JDRF’s long-term goals include delivering: •

A beta cell encapsulation product providing insulin independence for more than a year without the need for chronic immunosuppression. Novel therapies for beta cell survival and immune modulation that when used in combination can extend the period of insulin independence after diagnosis for more than two years.

Advanced-generation artificial pancreas systems such as those that deliver two hormones and those that have full (24-hour) automation features that further improve glycemic control. A glucose responsive insulin that provides glycemic control with a single shot per day, or less often. Novel therapies that improve eye disease in people with T1D. Therapies that prevent or delay the onset of insulin dependence for at least two years in people with autoantibodies for T1D.


2012 JDRF RESEARCH

FUNDING CURE RESEARCH

$65.1 MILLION

Beta Cell Health and Regeneration Therapies

$23.9 million

Immune Therapies

$6.8 million

Beta Cell Encapsulation Therapies

$10.4 million

Cure Biomarkers and Imaging Tools

$17.2 million

Cure Transportfolio Projects

$6.8 million


TREAT RESEARCH

$35.7 million

Artificial Pancreas Systems

$12.4 million

Glucose-Control Therapies

$2.5 million

Complications Prevention and Treatment Therapies

$20.8 million

PREVENTION THERAPIES RESEARCH

$8.2 million

General Research Projects

$1 million

TOTAL 2012 RESEARCH FUNDING

$110 million


DONATE. GENERAL DONATION MEMORIAL DONATION TRIBUTE DONATION SUPPORT JDRF AT WORK MAKE A STOCK GIFT DONATE YOUR CAR INCLUDE JDRF IN YOUR WILL Your tax-deductible gift will help JDRF create a world without T1D.

FOR MORE INFORMATION VISIT

http://jdrf.org/get-involved/ways-to-donate/

FUNDRAISE.

GET INVOLVED IN YOUR LOCAL CHAPTER WALK TO CURE RIDE TO CURE KIDS WALK TEAM JDRF Working together, JDRF chapter volunteers and staff have been responsible for raising more than $1.7 billion for diabetes research, as well as building supportive communities


ADVOCATE.

TELL YOUR STORY. WHO IS YOUR #1? Visit: http://jdrfstory.org

JOIN US

MAKE A CALL

Making a personal phone call to your Congressional Representative, and Senators.

CHILDREN’S CONGRESS

Every two years in Washington, D.C., JDRF’s Children’s Congress gives children the opportunity to personally show their Congressional Members how they feel about living with T1D and their daily struggles.

SEND A LETTER

Send a letter to your Congressional Representative, and Senators.

MOBILE ADVOCACY

Text “ACTION” to “37420” and sign up for our alerts today. (Message and data rates may apply.

TYPE 1 TALK

An online events tool on Facebook that’s specifically designed to help bring the local diabetes community together online.

PROMISE TO REMEMBER ME CAMPAIGN

Meet with your Congressional Members right in their local home office, and make sure that they remember YOU when they question if the federal government should continue to support uninterrupted T1D research.


IMPROVING LIVES. CURING TYPE 1 DIABETES.

GO ONLINE AND VISIT http://jdrf.org PHONE: (800) 533-CURE (2873)


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