LACTOPAD - ACNE - new natural treatment Exploring latest products for skin health During puberty the production of male sex hormones (androgens) increases in both girls and boys, which can stimulate the sebaceous glands to produce more sebum. In some people the sebaceous glands are extremely sensitive to androgens. Acne is caused by the effects of hormones on the pilosebaceous unit, consisting of a hair follicle, sebaceous gland, and a hair. The follicle becomes obstructed and an overgrowth of a normal skin bacteria, Propionibacterium acnes (P. acnes), causes destruction of the lining of the follicle. This process allows follicular material to enter the dermis, causing an inflammatory response. P. acnes is an anaerobic bacteria which multiply in the oxygen free environment under the skin, once a follicle becomes blocked. This in turn attracts the body's white blood cells and white blood cells attempt to surround and kill the P. acnes bacteria. Once there are enough P. acnes bacteria and white blood cells together, an infectious lump or closed comedone (whitehead) forms. This is how acne starts.
About Lactopad Lactopad contains an anti-microbial peptide produced from Enterococcus faecalis SL5 and is a good natural alternative to antibiotic treatment like Tetracycline, Erythromycin, etc. Lactopad also contains metabolic products (lactic acid, antibiotic substances) elaborated by the lactic acid bacteria culture and is lyophilized to dry powder by biotechnology. Lactopad has a strong inhibition effect on Propionibacterium acnes. In contrast to antibiotic compounds, anti-microbial peptides have a limited biological property and kill only target microbes selectively. Mechanism: Bacteriocin has a simple primary structure that is composed of polypeptide chain. The hydrophobic aminoterminal end of the peptides interacts with the cell membrane and makes a hole, and it kills the target microbes by changing the membrane potential. Acne is a very common skin disorder that affects many young people in early puberty. In some cases, acne is so severe that medical treatment is required. Antibiotics are frequently used with the potential risk of undesired side effects. Lactopad is a natural alternative based on an antimicrobial peptide produced from the cell culture of a strain of lactic acid bacteria.
Clinically proven The therapeutic effect and safety of Lactopad have been verified in a double-blind, randomised, placebo-controlled, phase III study for the treatment of mild to moderate Acne. A total of 70 patients diagnosed with facial acne vulgaris were enrolled in this study and 61 completed the 8 weeks of treatment. 37 patients were treated with Lactopad, and 33 with a placebo. Firstly, for the clinical improvement of the number of acne, 76.5 % (26 out of 34) of the Lactopad group showed an improvement that
All side effects were temporary and insignificant, and were improved with continued treatment. No other skin or physical problems were observed. The data supporting the safety of Lactopad includes the clinical data and the cytotoxicity test using human kera-tinocyte cell line where Hakat cells showed just 10% higher inhibition at 800 AU/ml compared to the control. Our results suggest that treatment with Lactopad can be effective for patients suffering from inflammatory acne. It also shows that whilst minor side effects may occur, Lactopad is safe to use.
was better than “fair” in four scale evaluation (excellent-good-fair-poor), while 51.9 % of the placebo group showed the same degree of improvement. For the decrease of numbers of pustules, the Lactopad group showed a higher rate of treatment efficacy. Secondly, in the examination with 10-point visual analog scale, the Lactopad group showed higher satisfaction compared to the placebo group. Thirdly, the side effects reported in the Lactopad group were unpleasant odour for 6 patients, dryness for 3 patients, and irritation for 2 patients, while dryness for 1 patient was reported in the placebo group. www.duolac.com
Cell Biotech offers a wide range of ready made Lactopad products including skin cream, skin tonic and wet wipes etc. for private label solutions. Besides offering finished formulated standard concepts to our customers, we also offer the opportunity to develop tailor-made solutions in order to meet individual needs and requirements.
The Journal of Microbiology, (February 2009), p. 101-109. Antimicrobial Activity of Enterocins from Enterococcus faecalis SL-5 against Propionibacterium acnes. J. Microbiol. Biotechnol. (2008), 18(7), 1308–1316. CBT-SL5, a Bacteriocin from Enterococcus faecalis, Suppresses the Expression of Interleukin-8 Induced by Propionibacterium acnes in Cultured Human Keratinocytes CTFA File number : 9082, Trade name: Lactopad Assigned INCI names: Maltodextrin, Enterococcus Faecalis Ferment