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ANNUAL REPORT

2015


KUIC Impact LETTER FROM THE PRESIDENT The past year has been one of growth and improvement for KU Innovation and Collaboration (KUIC). The goals for FY15 were 1) implementation of transparent processes for technology transfer and 2) the development and launch of an entrepreneurship program and culture at KU. Progress toward these goals has been significant. Technology commercialization now has extensive standard operating procedures in place. The triage of disclosure and patenting decisions are now based on a data-driven, transparent process. Faculty comprise the new IP Committee and use these data to make patent decisions on behalf of KU. Integration of two existing systems has resulted in a robust marketing platform that oers a strategic solution to technology promotion and outreach. This has resulted in an increase in both executed disclosures and license agreements to all-time highs at KU. Industry sponsored research at KU is also at an all-time high of over $14M. This growth demonstrates the research excellence at KU, the commitment of the university and the new partnerships forged during this year. KU has been recognized by both the Association of Public and Land Grant Universities (APLU) and the University Economic Development Association (UEDA) for the impact the university has had in innovation and economic engagement. This report describes both the metrics and examples therein that demonstrate the role KU plays in the economic growth of the region. Our team is dedicated to moving technologies discovered at KU to the market to transform the lives of people across Kansas and the world.

Interim Associate Vice Chancellor for Innovation & Entrepreneurship Interim President, KU Innovation & Collaboration


The University of Kansas continues to transform discoveries into new products and technologies that grow the economy and benefit society.”

Bernadette Gray-Little Chancellor

About KUIC INNOVATION + COLLABORATION + ENTREPRENEURSHIP Part of KU’s mission includes growing economic prosperity. In pursuit of this mission, KU educates leaders that businesses and communities need, helps create the jobs they will fill, and the companies at which they will find employment. KU is committed to turning discoveries into companies and jobs, and will continue to serve as a draw for businesses. This is key to KU’s mission and an important element of our strategic plan Bold Aspirations. Bold Aspirations embodies how KU values a culture of entrepreneurship among its faculty and students. Over the past four years, KU has expanded the commercialization of its technologies, built infrastructure to support corporate partnerships, enhanced the culture of entrepreneurship on campus, and increased partnerships with businesses. This has advanced university priorities by creating an integrated infrastructure that has mitigated barriers and provided a faculty-friendly environment.

As a national, public, research university, KU has a special responsibility to those we serve. Society stands to benefit from our discoveries, but so do our students – the next-generation workforce.”

James Tracy

Vice Chancellor for Research

KUIC leads the university as it fulfills its ambitious economic development mission. Working with private-sector companies, KUIC extends the university throughout Kansas and around the world.”

Richard Barohn

Vice Chancellor for Research, KU Medical Center

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In the near future, unmanned aircraft systems will be a multibillion dollar industry within the U.S., with uses in agriculture, film and photography, package delivery, search and rescue, and much more. However, avoiding airborne collisions is a safety hurdle that must first be overcome.”

Lei Shi, EECS Ph.D. Candidate, Inventor

UAVRadars, LLC DRONE COLLISION AVOIDANCE RADAR SYSTEM technology improves. Seeing

(SBIR) Assistance Program.

this rising need and a ripe

The latter led to a NASA SBIR

market, Shi went public with his

award to the company. His

sense-and-avoid radar in 2014.

business now occupies space

He had been researching radar

in the Bioscience & Technology

technology as a KU graduate

Business Center on KU’s West

assistant since 2010, when many

District. The work is far from

Lei Shi is a doctoral engineering

still considered drones the stuff

over. With the funding he

student turned entrepreneur.

of science fiction.

received, Shi continues to refine

With so many unmanned aircraft crowding the skies, avoiding collisions will become a priority.

Shi and his faculty adviser, Dr.

— and shrink — his collision

Christopher Allen, professor

In 2015 Shi launched a startup,

avoidance radar. It’s now hand-

of electrical engineering and

UAVRadars LLC, leveraging

sized but ultimately will be much

computer science, have co-

many resources across KU

smaller. The NASA award has

invented a miniature radar

including the KU Catalyst

provided critical funding for this

system that will help small,

student business incubator

development work and validates

unmanned aerial vehicles —

program and KUIC’s Small

the technology.

UAVs — sense what’s around

Business Innovation Research

them and avoid collisions. The timing couldn’t be better. Although 30,000 drones are expected to take off by 2020, the Federal Aviation Administration is limiting commercial drone permits until collision-avoidance 2

2015 is the year of agriculture drones, according to Fortune magazine. The legalization of drones is expected to create an additional $80 billion for the U.S. economy between 2015 and 2025, with agriculture being the largest chunk of that number. That’s good news for Kansas and its agricultural, aerospace, and technology industries. Economists predict the state will be No. 7 on the list of states that will see gains as drones take to the skies.


Proof of Concept FUNDING DEVELOPMENT OF NEW PRODUCTS The KU Proof of Concept (POC) funds development of projects that demonstrate a technology’s market viability to potential investors and partners. POC projects consist of a defined set of milestones that, when completed, help overcome a specific hurdle to an innovation’s transfer to the market. Eligible projects include those in which the university has applied for intellectual property protection in the form of a provisional patent application within the past five years. POC projects are competitively awarded. The 2015 recipients were:

LISA FRIIS AND PAUL ARNOLD

Department of Mechanical Engineering; Department of Neurosurgery The invention uses direct current electrical stimulation to accelerate bone fusion and healing. A recent pilot study using sheep was successful. The POC award will be used to improve manufacturing methods and help identify other targeted orthopedic applications.

LAIRD FORREST

Department of Pharmaceutical Chemistry The invention, nanohyaluronan rapamycin (NanoTor), targets breast cancer stem cells and delivers an anticancer agent with unique efficacy. These cells resist conventional chemotherapy and radiation, which causes recurrence after treatment. NanoTor treats tumors and also prevents metastasis.

CHRISTOPHER ALLEN

Department of Electrical Engineering and Computer Science

The invention is a miniature radar-based device for use in unmanned aerial vehicles and designed to prevent airborne collisions. The POC award will be used to overcome hardware limitations, such as processing power and detection range, and support continuing commercialization development.

STEPHEN WALLER Department of Infectious Diseases

The invention uses anchored, adjustable wires attached adhesively to the skin to close large wounds. This reduces the risk of the wound re-opening. promotes healing, and reduces surgical scarring. The POC award will support the development of research and pre-production prototypes and testing.

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Partnerships INSPIRING INNOVATION THROUGH COLLABORATION STIMULATING ENTREPRENEURSHIP University partners, such as the Center for Entrepreneurship at the KU School of Business and the School of Engineering, assist in creating programs to help stimulate entrepreneurship among our students and faculty. Events and activities with our university partners include A Celebration of Innovation Startup Showcase and Startup School@KU that serve to drive an entrepreneural culture at KU. EXPANDING ECONOMIC OPPORTUNITIES The Bioscience and Technology Business Center (BTBC) is the economic development partner of KU. BTBC provides business assistance and space to our startup companies. We collaborate on business attraction, talent, and entrepreneurship educational programming. The KU Endowment Association partners with us to enhance the University’s engagement with companies.

REGIONAL ENTREPRENEURIAL ECOSYSTEM KUIC has established a new partnership with Pipeline, a fellowship program that provides a rigorous year-long business development program for 10-12 high-potential entrepreneurs each year. The partnership enables KU to facilitate a more direct relationship between university researchers and Pipeline’s entrepreneurs, which in turn encourages the transfer of KU discoveries into new consumer products and startups. Additionally, the partnership means all KU-affiliated entrepreneurs can now apply to become Pipeline fellows.

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Capstone Program TECHNOLOGY DEVELOPMENT & STUDENTS

I never thought as a KUME student I could use my skills to design bandages for the medical industry. As the project developed, I saw more clearly how mechanical engineering techniques can be used in all industries. It’s an exciting conclusion to my mechanical engineering studies at the University of Kansas.” Phillip Shields, Senior Engineering Student

KUIC has an ongoing need to further develop technologies in order to attract the attention of companies that will ultimately bring them to the market. Mechanical Engineering developed an industry-sponsored capstone project program in 2012 that has involved over 23 companies sponsoring 40 projects. In January of 2015, a partnership was established between the Department of Mechanical Engineering and KUIC to tap into student expertise to do important development work, while students gained valuable experience through the Capstone program.

Beginning with ideas generated by faculty inventors, mechanical engineering students first consider alternative designs, and then refine their concepts. Working with the inventors, the most promising designs are subsequently developed. Ultimately, prototypes are built that demonstrate the feasibility and efficacy of the students’ solutions. Included as part of the projects are detailed cost analyses to ensure that the concepts are economically, as well as technically viable. The 2015 projects include: • Development of minimally invasive devices to screen for esophageal cancer. • Design of new protective barriers to eliminate infections associated with use of venous and arterial catheters. • Synthesis of technologies to develop innovative bandages that will reduce post-operative infection of healing wounds.

We are delighted to collaborate with KUIC in our capstone activities. This type of partnership is, to my knowledge, unique in academia. It is also testimony to the value our students can add to the early-stage design of potentially disruptive commercial products.” Ted Bergman, Chairman of Mechanical Engineering

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PKD has been considered untreatable with symptoms leading to kidney failure in approximately one half of patients by the age of 60. ”

Darren Wallace, Department of Medicine and the Kidney Institute

Progress for Polycystic Kidney Disease Patients NOVEL COMPOUNDS COULD LEAD TO NEW THERAPY Currently there are no available therapies to treat the cellular mechanisms responsible for PKD.

of Kansas Medical Center are working on developing a method to treat PKD that specifically targets and inhibits two key cellular mechanisms that cause

Facts about

PKD

The average sized human kidney is .25 to .35

aberrant proliferation of the Autosomal Dominant Polycystic

fluid-filled cysts.

Kidney Disease (PKD) is a lethal, hereditary disorder. Fluid filled

Using PKD cells in three

cysts form in the kidneys and

dimensional cultures, the

continue to grow unabated,

proposed treatment, utilizing

leading to massively enlarged

novel boron-based compounds,

kidneys, loss of renal function,

has shown a reduction in

and death of the patient. The

cyst formation and growth of

disease is caused by mutations

existing cysts. As a result, this

in two genes that code for

method could lead to a clinical

polycystin-1 and polycystin-2

breakthrough in the field of PKD

[PKD1 and PKD2 respectively].

that could positively impact the lives of millions of people who

Drs. Darren P. Wallace and

are afflicted with this disease.

Polycystic kidneys can weigh OVER 30 pounds and be as large as a football. 1 out of 500 people have PKD - that‘s

12.5

million people worldwide regardless of age, gender, or race

Bhaskar C. Das at the University Source: PKD Foundation

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Reversing Diabetic Neuropathy TREATMENT APPROACH WITH NOVOLOGUE MOLECULES has been conducted in the field

new research at KU as it

of DPN, little to no success

further develops the existing

had been previously observed.

technologies. Novologues

However, utilizing small

would represent a first-in-class

molecules developed in the Blagg

approach toward treating a

Laboratory, the Dobrowsky team

condition that affects 60 to 70

Brian Blagg, professor of

was able to conduct intricate

percent of patients with diabetes.

Medicinal Chemistry at KU,

studies that produced exemplary

The results clearly demonstrate

and Rick Dobrowsky, professor

preclinical data to support the

that this novel approach toward

of Pharmacology & Toxicology

use of such compounds for the

the treatment of DPN is unique

at KU, have developed a set of

treatment of DPN. The research

and groundbreaking for those

novologue molecules that are

was supported by NIH funding

suffering from neuropathy.

capable of reversing diabetic

and gave a boost to KU’s ongoing

peripheral neuropathy (DPN).

efforts to develop the next

For KU, as with most

DPN is a common complication

generation of novologues.

universities, technology

First-in-class solution to a complication that affects 60%-70% of diabetic patients.

of diabetes that presents as

developed in-house and

muscle weakness, numbness,

In 2010, the two professors

licensed to outside companies

and tingling in the limbs.

presented results on the use of

generates revenue that in turn

Novologues include a broad

the lead novologue against DPN,

is reinvested to fund additional

group of compounds that

which led to several patented

commercialization activity and

are emerging as an attractive

discoveries culminating in KU’s

related research. The discoveries

approach for treatment of

largest license agreement with

of Profs. Blagg and Dobrowsky

cancer and neurodegenerative

a pharmaceutical company.

add a great value to KU’s overall

diseases. While much research

The company expects to fund

economic development mission.

Experiments with the lead compound are successfully progressing toward regulatory approval. The lead compound, once approved by the FDA, will significantly improve the quality of life for millions of diabetic neuropathy patients all over the world.”

Rick Dobrowsky, Department of Pharmacology & Toxicology

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2015 Metrics

119

81 INVENTION DISCLOSURES +23% OVER FY14

PATENTS FILED

79th in the world among universities receiving U.S. patents

50 PATENTS ISSUED 70 60 50 40 30 20 10

in license income Source: 2014 AUTM Licensing Survey. Survey reflects FY14 data.

+32% FY14 FY15

8

44th in the U.S.


$9.9 MILLION

LICENSE REVENUE

40

3

STARTUPS

7

STARTUP COMPANIES

New

Located in the BTBC

25%

LICENSE AGREEMENTS EXECUTED

128

CORPORATE PARTNERS Engaging multiple ways across KU

$14.2 MILLION INDUSTRY SPONSORED RESEARCH

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Technologies* BY SECTOR BIOTECHNOLOGY Human Toll-like Receptor 8-Selective Agonistic Activities in 1-Alkyl-1H-benzimidazol-2-amines Specialized Immunonutrition Benefits to Cancer Surgery Patients Abcb6 Antibody

CREATIVE WORKS Insta-sim Family Employment Awareness Training (FEAT) TBRS Submax App Promoting Refugee Women’s Health in Resettlement Eating Pathology Clinical Outcomes Tracker (EPCOT)

ENERGY-ENVIRONMENT System for User-involved, Information-aware, Controlbased Battery Charging

ENGINEERING Annular Aerial Vehicles and Methods of Use Arched Aerial Vehicles and Methods of Use 3D Printing of Metals Feather-Bearing Ball Aerial Vehicles and Methods of Use Navigation for Small UAVs Using Ground-Based Broadcast Transmitters Metal Catalyst Free Chemical Vapor Deposition of Bi-layer Graphene on Dielectric Substrates

FOOD Fits: Food Groups

Method and Application of Induction of Aircraft External Surface Vibration

FOOD Fits: Grocery Store Tour

Spherical Aerial Vehicle with Folding Propulsors

FOOD Fits: Food Portions

Peaked Aerial Vehicle

FOOD Fits: Nutrition Fact Labels

Rotating Oblate Aerial Vehicle

Health Literacy Calculator

Shrouded Aerial Vehicle

Health Literacy Calculator

Changeable Aerial Target

DIAGNOSTICS

Aerial Target

Steroidal Probes for Oncogenic Cytochrome P450 17A1 that Achieve Selectivity over Adverse Effect-associated Cytochrome P450 21A2

Convertible Aerial Target

In Vivo Measurement of Brain Ascorbate Increase via Intravenous Infusion of Pharmacologic Ascorbate using Magnetic Resonance Spectroscopy

Method and Apparatus for Enhancement of Aerial Vehicle Pilot Training

DRUG-DELIVERY Proximity-driven Modification of Protein Lysine Residues Ethylene Glycol-linked Dimers of Cholesterol as Stabilizers of Liposomes Drug Delivery Compositions and Methods Tissue Reprogramming via Microvesicle Transport

Rectanguloid Aerial Vehicle

Circular Aerial Vehicle Spherical Aerial Vehicle and Methods of Use 3-dimensional Ad-Hoc Localization System A Novel Polymerizable Amine Co-initiator for Dental Application Self-returning Unmanned Aircraft using Self-DGPS Biomolecule/Carbon Nanostructure Nanohybrids for Highperformance Optoelectronics

*Invention disclosures received by KUIC in FY15

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ENGINEERING, cont. Turbomachinery Tip Flow Control using Leading-edge to Tip Aspiration Rhodium Sulfide Catalyst with Electrically Conductive Bridge between Catalyst and Support Catalytic Synthesis of Dicarboxylic Acids from Biomass based Feedstocks

MEDICAL DEVICES

THERAPEUTICS Antibiotic Activity of Iron Sequestering Polymers Micelle Sequestrant Polymers for the Sequestration of Bile Acids, Cholesterol, and Fat in the GI Tract Compounds Inhibiting Musashi Proteins A Protective Antigen Platform Based on Fusion of the Tip and First Translocator Proteins of Type III Secretion Systems of Gram Negative Bacteria

Cardiotocography - Transducer Attachment Device

Chemical Compounds for Treatment of Sickle Cell Disease, Cooley’s Anemia and certain β-thalassemias

Method and Apparatus for Producing Enhanced Cavitation Activity in Soft Tissue

Rationally Designed Human TLR8-selective Agonists

Method and Apparatus for Image-directed Nerve Growth Achieving Paste-Like Rheological Behavior Prior to Crosslinking Hydrogels Tongue-Palate Speech Pressure Appliance

RESEARCH TOOLS Viral-free and Animal-free Safe and Efficient Method of Generating Induced Pluripotent Stem Cells (iPSCs) from Human Somatic Cells Recyclable Magnetic Co/C Hybrid ROMP Oligomeric Phosphonyl Dichloride (Co/C-OPC) as a Novel and Selective Scavenge High Throughput Permeability Assays for Drug Discovery Development of a Plasmid that is Stable Without Required Selective Pressure for In Vivo Studies of Bacterial Pathogens

SOFTWARE Medical Evaluation App : “ME”

Neuroattenuated Herpes Simplex Virus Syntheses, Characterization and Biological Evaluation of Poly-TLR Agonists Hyaluronic Acid Conjugation of TLR7/8 Agonists for Lymphoid Tissue Delivery Sulfonamidebenzamides as Inducers of Apoptosis in Kinetoplastid Parasites Adjuvantic Activitiesof Amphotericin B as TLR-2 and TLR-4 Agonist Antigen-Drug Conjugates (AgDCs) Material for Treatment of Bone Fractures 4-Methoxyestrogens Can Modulate Lipid and Cholesterol Profiles Highly Potent Mu Opioid Receptor Ligands Derived from Salvinorin A TGX221 Analogs for Prostate Cancer Treatment

Silence the Smoking

2-(Arylsulfonyl)-1,2,3,4-tetrahydroisoquinoline-6-carboxamide Derivatives and their use as Antagonists of Kappa Opioid Receptor-mediated Signaling

Curb your APPetite

Ciclopirox Prodrug for the Treatment of Bladder Cancer

Environmental Space-Time Machine

Noviomimetics as C-terminal Hsp90 Inhibitors

Resident Rank: A Web-based Interview Evaluation Software

Novel Boron Containing HIF (Hypoxia-Inducible-Factor) Inhibitors

NiDAN Electronic Exchange for Assessment of Candidates for Transportation

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Innovation & Economic Prosperity DESIGNATED CAMPUS In 2015, the University of Kansas earned a prestigious distinction for its leadership in fostering local and regional economic development. The Association of Public and Land-grant

participation in encouraging economic engagement

Universities (APLU) named KU to its 2015

among peer institutions.

class of Innovation & Economic Prosperity Universities. KU is one of only 18 institutions

KUIC acted as a convener of University assets

nationwide chosen this year, joining just 30

in economic engagement. Accomplishments

others selected since the program began in 2013.

were highlighted in education and workforce development, innovation and technology

The APLU designation followed a thorough

commercialization, and community engagement.

self-study that included extensive regional stakeholder input. The application then went

The designation acknowledges KU’s work with

through a rigorous independent review process.

public and private sector partners in their states

Scoring was based on a range of criteria

and regions to support economic development

emphasizing universities’ development of their

through a variety of activities, including innovation

economic engagement enterprise, their planning

and entrepreneurship, technology transfer, talent

efforts around economic engagement, strategic

and workforce development, and community

communications around these efforts and

development.

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Board of Directors The KUIC board of directors is comprised of 15 members and is chaired by the Provost and Executive Vice Chancellor of the University of Kansas. Members are leaders from the university and industry representing both large and small companies throughout the region. The board serves to guide the activities of KUIC and provide overall governance of the organization.

Members Jeffrey Vitter, Ph.D., Chair

Kevin Hahn, D.V.M., Ph.D.

Tim Siskey, Treasurer

Sara Mary Hall, M.Sc.

Chief Financial Officer University of Kansas Medical Center Research Institute

Chief Executive Officer Orion BioScience Inc.

Kim Barksdale, Secretary

Joseph Heppert, Ph.D.

Provost & Executive Vice Chancellor University of Kansas

Chief Scientific Officer and Executive Vice President NextSource Biotechnology, LLC

Deputy Director, Human Resources & Corporate Secretary University of Kansas Medical Center Research Institute

Associate Vice Chancellor for Research University of Kansas

Richard Barohn, M.D.

Professor University of Kansas Medical Center

Vice Chancellor for Research University of Kansas Medical Center

Lisa Stehno-Bittel, Ph.D.

Cory Berkland, Ph.D.

James Tracy, Ph.D.

Solon E. Summerfield Distinguished Professor University of Kansas

Vice Chancellor for Research University of Kansas

Jamie Caldwell, M.B.A

Michael Webb, M.B.A.

Executive Director University of Kansas Medical Center Research Institute

President and Chief Executive Officer Allegro Diagnostics

E. LaVerne Epp, J.D.

Steffani Webb, M.B.A.

Executive Chairman Bioscience & Technology Business Center

Vice Chancellor of Administration University of Kansas Medical Center

Doug Girod, M.D.

Executive Vice Chancellor University of Kansas Medical Center

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Back row (from left): Matt Koenig, Bethany Scothorn, Tricia Bergman, Chance Hoskins, Chris Hanson, Michael Patterson, Bridget Stull and Chelsea Nuttall Front row (from left): Aswini Betha, Rajiv Kulkarni, Julie Nagel, Julie Murray, Claire Sabin. Not pictured: Laura Irick and Mary Ann Roesner.

Bioscience and Technology Business Center 2029 Becker Drive, Suite 142 Lawrence, KS 66047 Phone: (785) 864-6401

kuic@ku.edu

KUMC Research Institute 4330 Shawnee Mission Parkway, Suite 229 Fairway, KS 66205 Phone: (913) 588-5711

kuic.ku.edu


University of Kansas Innovation & Collaboration 2015 Annual Report