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INDONESIAN INSTITUTE OF SCIENCES

THE E L I F PRO

RESEARCH CENTER FOR

CHEMISTRY kimia.lipi.go.id


CHEMICAL ANALYSIS LAB RESEARCH CENTER FOR CHEMISTRY

Type of Analysis  Analysis the determination of chemical compounds  Analysis of food, feed, water, microbiology  Analysis of environment (ambient air, air emissions, etc.)  Analysis of metal content  Analysis of antioxidant, anti-diabetic Excellences  Analyzer: NMR 500 MHz (the only one in Indonesia), FTIR, LCMS, GCMS, GC, AAS, HPLC, Spectrophotometer, BET, etc.  Competent HR analysts  The laboratory is certified to ISO 17025 Applications and Benefits  Determine the type of c hemical compound  Determine the level of environmental pollution  Determine the type and composition of metal content  Determine the activity of the compound that has anti-oxidant/anti-diabetic, etc.


Struktur Organisasi P2 Kimia LIPI Organization Structure of RC Chem LIPI

Message from MESSAGE FROM DIRECTOR OF RCCHEM Head of RCChem

Dear readers, It is an honor and privilege writing to you as the new Director of RCChem, a role that I officially began at June, 2014. Thank you for your trust and support. In the middle of 2014, we had structure of five research groups: (1) Catalysis and Macromolecular, (2) Biomass Energy & Environment, (3) Food Chemistry, (4) Active Pharmaceutical Ingredients, and (5) Analytical Chemistry. Hopefully with the synergy of the five research groups, our performance in research and development will improve significantly. In the future years, we will be facing much bigger national and global issues, including social, political, economic, and environmental issues, such as population growth, deadly disease, scarcity of food and energy, and environmental destruction. It is our mandate to change the problems into challenges through science and technology. For the readers, we hope that you will find this booklet useful and interesting, and it will facilitate you to make contact with our staff that can help you. As stated in our motto, "Chemistry for Better Life", together with you all, we can be the agent of change to make the life around us be better. Regards,

Dr. Eng. Agus Haryono

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TABLE OF CONTENTS Subtitle

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Message from Director of RCChem Table of Contents Introduction Pillars & Programs Major of Achievements Human Resources Organizational Structure Group Research Service & Support Recent Researches Gallery

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1 2 3 4 5 7 8 9 14 15 19


INTRODUCTION Research Center for Chemistry (RCChem) is one of Indonesian government research institutes under the Indonesian Institute of Sciences (LIPI) which was established in 1958. The main objectives of the Research Center for ChemistryLIPI are:  Carry out research and development (R&D) in Chemistry fields and

disseminate the results to public in supporting Indonesian sustainable economic development.  Promote science and technology to industrial and scientific communities.

VISION The vision of RCChem is derived from the vision of LIPI as follow: “to be a world class research center that advance science and technology in the field of chemistry for enhancing the quality of life and national competitiveness “. As stated in our motto, "Chemistry for Better Life", we are committed to achieve strong international reputation by contributing significantly in developing science and technology for academic, industry, community and global environment. As an Indonesian leader of R&D for chemical science and technology, we continuously make effort in performing R&D in five focused areas: (1) Catalysis and Macromolecular, (2) Biomass Energy & Environment, (3) Food Chemistry, (4) Active Pharmaceutical Ingredients, and (5) Analytical Chemistry.

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PILLARS & PROGRAMS The activities in the Research Center for Chemistry are developed based on five pillars, i.e.:  Carry out significant researches for the benefit of the nation and scientific    

communities. Manage technology transfer, incubation, and research commercialization. Management based on clean administration and good governance. Openness to innovation for facing national and international challenge. Prosperity for all, as stated in our motto: "Chemistry for better life”.

In general, the activities can be classified into programs as follows: Catalysis and Mcromolecular  Chemical engineering process  Catalysis technology  Polymer synthesis technology Biomass Energy and Environment  Waterwaste treatment  Environmental monitoring  Re-using waste to product  Hazardous waste management Food Chemistry  Functional foods  Other specialty food (nutraceuticals) Active Pharmaceutical Ingredients  Natural products drug discovery  Development of pharmaceuticals via organic synthesis and medicinal chemistry  Development of phytopharmaceuticals and cosmetics Analytical Chemistry  Metrology in chemistry  Advanced analytical chemistry Technology Management and Dissemination  Development of information and promotion system  Development of research cooperation and implementation Program on Institutional  Development of human resources  Development of supporting infrastructure

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MAJOR ACHIEVEMENTS With regard to following achievements, RC Chem has gained international acknowledgment such as: (1) appointed by TWAS (The World Academy of Sciences, Italy) as an international focal point for chemistry in Indonesia, (2) Recognized internationally as a Designated Institute of metrology in chemistry at the Asia Pacific Metrology Program Summit, (3) Appointed as sub-committee on Food Science and Technology by the ASEAN Committee of Science and Technology (a) Achievement in Scientific Research, Publications and Patents Some of major achievements of research in RC Chem are: 1. Research on surfactants and others production technology based on palm oil and its derivation. Some output of these research has been registered for patents and implemented in industry, such as Gliserol Monooleat (GMO), Gliserol Monostearat (GMS), Polietilen Glikol Oleat (PEG Oleat), Sorbitol Oleat, Isopropil Miristat (IPM), Isopropil Laurat (IPL), Isopropil Oleat (IPO) 2. In 2001, RC Chem managed "Production Processes of Tempe-based Frozen Food and Its Manufactured Products" to patent. In 2009-2010, under co-operation with Curtin University (Australia), RC Chem tried to develop a Tempe-like fermentation result of Australian lupines to obtain higher nutrient contents 3. Research on Inulinfruktotransferase Actinomicetes for the production of DFA III (Difructose-dianhydride III) as a functional food anti-osteoporosis. 4. Pharmaceuticals development for cardiovascular from herbal medicine, such as (a) development of phytopharmaca from breadfruit plants for cardiovascular, (b) synthesis of salicylic amide derivatives as UK-3 analog for anti-cancer drugs, and (c) Lipistatin as anti-cholesterol drug 5. Research and development of biomass based bio-energy, by establishing a pilot plant construction for bio-ethanol production with cooperation of Korea International Cooperation Agency (KOICA), Korea Institute of Science and Technology (KIST) and Changhae Energeering Co. Ltd. During last five years, about 70 papers were published internationally and over 270 papers published nationally. More than 40 patents were registered and under process of registration. The remaining of scientific achievements were published in the form of books, mass media articles, etc. The papers are published in international scientific journals, such as Pakistan journal of Biological Sciences; Journal of Applied Science; ITE Letters on Batteries, New Technology & Medicine; Natural Products Research; Journal of Sol-Gel Science and Technology; Journal of Material Science; etc.

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MAJOR ACHIEVEMENTS (b) Achievement in Implementing Research and Developing Business Unit Incubator Researches in RCChem are implemented through several stages of businesstechnology development. Started with research in laboratories, testing to market, build pilot plan, grow in incubator until spin off, RCChem successfully made one of research in tempe-fermentation to be a spin off company which evolve as the best company in Indonesia and Asia. Currently, similar project is being developed for palm oil and cosmetics based on vegetable oil (such as body soap). Production of materials / active extract from the plants has been also being conducted for standardized herbal medicine, phytopharmaca, or functional foods (e.g. production of methyl cinnamate, DFA III, a standardized extract from the mango peel, soursop leaves, red betel leaves, breadfruit leaves, etc.). (c) Research Project Cooperation As internationally recognized institution, RCChem have cooperated with other world class institution. Some of them were listed below. 1. Zhejiang Univ. China: (ZU-LIPI Collaborative Project on Herbal Medicine): cooperation in the research field of screening bio-active for anti diabetes, cardiovascular, and hepatitis from any extracted Indonesian plant. 2. Departement of Chemistry-Osaka City Univ. Japan (JSPS-LIPI Joint Research 20062011): research cooperation on synthesizing derivation of UK3 for anti-cancer and developing anti cancer agents for endophytic. 3. Curtin University (Curtin-LIPI GDCRC): research cooperation on producing tempe lupin. 4. Technical University Delft, Netherland and Indonesian Ministry of Science and Technology: research cooperation on diesel particulate emission by catalytic processes. 5. International Basic Science Program–UNESCO for research on nanoporous material based on clay. 6. Korea International Cooperation Agency, Korea Institute of Science and Technology and Changhae Energeering Co.Ltd.: developing biomass based bio-energy 7. Korea Research Institute of Standards and Sciences: developing metrology in chemistry, especially in gas metrology. 8. Korea Institute of Science and Technology: research cooperation in the field of catalysis, environment and management since 1996. 9. Physikalisch-Technische Bundesanstalt, Germany, for developing metrology in chemistry. 10.Fakultas Kedokteran Universitas Indonesia, Kobe University, Japan International Cooperation Agency: identification of anti-Hepatitis C Virus (HCV) substances and development of HCV and Dengue vaccines. 11.Biology Recearch Center and Univ. of California, USA: Therapeutic Screening of Natural Product Medicinal Plant from Mekongga Forest, Indonesia.

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HUMAN RESOURCES RCChem LIPI employs about 230 staffs, including researchers, technicians, analysts, strategic planners, engineers, IT specialists, archivists and administration staffs. The education qualification of employees consists of 25 staff of doctoral degree, 66 staff of master degree and remaining staff graduated as undergraduate degree or high school.The competency of staff covers various specialized education background, i.e. chemistry, polymer, catalyst, chemical engineering, biochemistry, microbiology, organic chemistry, pharmacy, chemical engineering, environmental engineering, information engineering, electrical engineering, mechanical engineering, and industrial engineering, veterinarian, medic doctor, marketing, management, economy, financial accounting, law, communication, and design.

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Formation of research groups to sharpen competency skills Enhancement of structural and functional positioning Seminars and internal discussions Assignment of employees to attend training and workshops Inviting experts from domestic and international Assignment of employees to pursue higher education in domestic and international university  Provision of infrastructure for religious activities, health, and safety  Provision of facilities for resting and refreshing

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Human resources are developed through several ways such as:      

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Struktur Organisasi P2 Kimia LIPI Organization Structure of RC Chem LIPI

ORGANIZATIONAL STRUCTURE

CHAIRMAN OF LIPI

DEPUTY FOR ENGINEERING SCIENCES

DIRECTOR OF RESEARCH CENTER FOR CHEMISTRY

ADMINISTRATION DIVISION

UPT BPPTK LIPI YOGYAKARTA

FINANCE SUBDIVISION

TECHNOLOGY MANAGEMENT AND DISSEMINATION DIVISION

TECHNOLOGY MANAGEMENT SUBDIVISION

HUMAN RESOURCES GENERAL AFFAIRS SUBDIVISION SUBDIVISION

INSFRASTRUCTURE MAINTENANCE DIVISION

GENERAL FACILITIES SUBDIVISION

DISSEMINATION AND COOPERATION SUBDIVISION

LABORATORY EQUIPMENTS SUBDIVISION

RESEARCH GROUPS

CATALYSIS AND MACROMOLECULAR

BIOMASS ENERGY AND ENVIRONMENT

FOOD CHEMISTRY

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ACTIVE PHARMACEUTICAL INGREDIENTS

ANALYTICAL CHEMISTRY


RESEARCH GROUP

Catalysis and Macromolecular BACKGROUND The development of advanced catalysts and macromolecules directed to manage and increase the added value of Indonesia's natural resources significantly. By strengthening the ability of researchers in the field of advanced catalysts and macromolecules, the researches in this area could lead to the progress of nation. GOALS  Technology and production of advanced catalysts for the conversion of natural resources  The development and synthesis of macromolecules for chemical industry

MAIN RESEARCH ACTIVITIES

Sub-Research Groups:

 Synthesis of catalysts for fine chemical production

 Catalysis  Macromolecular  Process Technology

and development of macromolecules for coating, adsorbent and packaging materials  Research implementation of catalysis and macromolecules in health

POTENTIAL USERS Fine chemical industries, catalyst and adsorbent industries, ship industries, packaged food material industries, polymer industries, cosmetic industries, hospitals.

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RESEARCH GROUP Biomass Energy and Environment BACKGROUND Indonesia has a big challenge to increase the independence of the energy sector in order to support sustainable development. Most of national energy supply system oriented to fossil energy use, rather than nonfossil energy use/renewable energy. The use of fossil fuels contribute to increase greenhouse gas emissions that affect to global warming. Indonesia as the country with the greatest biodiversity in the world, has many potential of biomass. Biomass from agriculture and forestry wastes have not been explored widely. Those wastes can be converted into biofuels, which will substitute fuels from fossils. GOALS Contribute and help governments, communities and industries in order to: (i) Develop biomass energy as an environmentally friendly alternative energy, (ii) Participate in efforts to reduce greenhouse gas emissions that lead to global warming, (iii) Prevent environmental degradation, air, soil, and water caused by construction activity and industrial activity. MAIN RESEARCH ACTIVITIES 1) Sub-Research Group Conversion of Biomass Bioenergy Produce bioenergy/environmentally friendly fuels in liquid and gas. The process of conversion through fermentation, gasification, thermochemical, etc. 2) Sub-Research Group Biological Refinery Process of biomass converting to produce fuels and chemicals as co-fine chemical products. 3) Sub-Research Group Waste Management Process Manage the process of converting biomass waste and bio-refinery. 4) Sub-Research Group Environmental Impact Assessment Assess the impact from biomass conversion activities and bio-refinery. 5) Sub-Research Group Methods of Environmental Analysis Development Develop and provide analytical methods for materials characterization, products and waste biomass conversion and bio-refinery. POTENTIAL USERS  Governments  Societies  Transportation industries  Agro Industries  Cosmetic Industries

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RESEARCH GROUP Food Chemistry BACKGROUND Indonesia has abundant natural resources that can be utilized as raw material for functional foods and foods rich in nutrients, in order to assist the government to improve public health and stability of food security. AIM To strengthen competencies and increase the value of inventions in the field of food chemistry through research and development of functional foods and nutritional food, to create and discover new knowledge that have broad impact, which supports the economic value of innovation. FUNCTIONS Conducting research, technical assistance, planning, implementation and reporting of research activities in the field of functional food chemistry and nutrition GOALS a) To develop functional food ingredients, formulation of functional foods and supplement/ nutraceutical products based on bioactive ingredients from local raw materials for degenerative diseases. b) To develop nutrient-rich foods based on biotransforma-tion and specialty food processes from local cereals, grains, fruits and animal to overcome malnutrition and taste MAIN RESEARCH ACTIVITIES 1) Sub-Research Group Functional Foods a) Development of Functional Food for Diabetes/Obesity Based on Bioactive Polysaccharides from Local Micro-algae b) Development of Chitooligosaccharide from Local Crustaceans Group as Functional Food for Diabetes c) Development of Nutraceutical Products DFA III from Inulin Dahlia Tubers and Ginger Extracts for Osteoporosis 2) Sub-Research Group Nutritional Foods a) Development of Sorghum (Sorghum bicolor L) for Savory Flavor and Amino Acids Sources by Enzymatic Hydrolysis b) Development of Processed Food-Based Cashew Fruit POTENTIAL USERS  Food Industries  Chemical Industries  Pharmaceutical Industries  Universities  Research institutes  Micro, Small, and Medium Enterprises (MSMEs)

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RESEARCH GROUP Active Pharmaceutical Ingredients (APIs) BACKGROUNDS  There are still many incidents of degenerative and infectious diseases in Indonesia.  Most of the APIs in Indonesia are still imported, while the abundant renewable sources of the APIs in Indonesia are not fully utilized yet. AIMS Discover and develop APIs from plants, microorganisms, and marine organisms for degenerative and infectious diseases. FUNCTION As a pot for competence and synergy building between LIPI researchers in the field of drug discovery and development. GOALS Discover antibacterial, anticancer, antidiabetics, antidengue, antihypercholesterolemic, and antimalarial APIs. MAIN RESEARCH ACTIVITIES 1) Subgroup Natural APIs for Degenerative Diseases a) Clinical test of sukun extract as phytopharmacy for antidiabetics and hypercholesterolemia b) Discovery of marine antidiabetics c) Development of Macaranga spp. as antihypercholesterolemics. d) Formulation of herbal antidiabetics 2) Subgroup Synthetic APIs for Degenerative Diseases a) Synthesis of derivatives of butyrolactone from Aspergillus terreus for antidiabetics b) Synthesis of dimers of phenol derivative for antidiabetics 3) Subgroup Natural APIs for Infectious Diseases a) Natural antimalarial drug development b) Standardized herbal antidengue drug development c) Development of marine endophytic chemicals as anticancer d) Development of marine antibacterials e) Development of natural anticancer 4) Subgroup Synthetic APIs for Infectious Diseases a) Discovery of andrographolide derivatives as antimalarials b) Discovery of artemisinin derivatives as antimalarials POTENTIAL USERS  Domestic pharmaceutical and herbal industries  Ministry of Health of the RI  Indonesian society

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RESEARCH GROUP Analytical Chemistry BACKGROUND Analytical Chemistry Currently, various problems related to chemical measurement capability are occurred such as the cases of rejection of export commodity by countries of destination, misusing of non-food grade chemical materials for food. The excess of content of toxic chemicals substance in food and environmental than the limit required and the presence of many of imported products with low quality and containing hazardous material are often happened in Indonesia. Due to those problems, the improving of measurement capability based on the metrology in chemistry principles are necessary to be carried out in order to obtain the accurate, traceable of measurement result as well as its acceptable in not only national but also international level. Therefore, the dissemination of traceability through reference material for achieving the comparability of measurement result becomes challenge for Research Center for Chemistry-LIPI especially laboratory of metrology in chemistry. AIMS Establish Research Center for Chemistry as national laboratory for metrology in chemistry through the activity of reference material development in order to ensure the valid of measurement result. FUNCTIONS Disseminate measurement traceability to testing laboratory sothat the accuracy and comparability of national of measurement result can be assured and it can be internationally recognized. GOALS Prepare traceable certified reference materials to Standard International according to ISO Guide 34 and 35. MAIN RESEARCH ACTIVITIES Prepare traceable certified reference materials to Standard International according to ISO Guide 34 and 35. The certified reference material prepared such as metals in pure standard solution, metals in drinking water, metals in rice flour, pesticide residue in fruit, benzoate in food, melamine in milk, Poly Aromatic Hydrocarbon in processes food, secondary buffer pH, conductivity of electrolyte, exhaust emission gas, and greenhouse gas. POTENTIAL USERS Entire chemical testing laboratory  domestic industry  government  private

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SERVICE & SUPPORT Technology Management and Dissemination Services  Cooperation in the development

or implementation of chemical research  Chemical analysis services, data interpretation

 Consultation/technical assistance, 

student guidance Proficiency test for chemical laboratory

Technology transfer and licensing  Training, workshop, others 

Supports  Experienced staff which competent in their field  Accredited laboratory and infrastructure  Intellectual property protection

 Promotion and information system  Market and economic feasibility studies  Others

Customers and Partners Center for Forensic Laboratory of Indonesian Police Department, The National Agency of Drug and Food Control (BPOM), National Standardization Agency of Indonesia (BSN), petroleum industries; food industries; drug and pharmaceutical industries; petrochemical industries; textile industries; pulp and paper industries; electricity company; domestic and international universities, government agencies, other research institutes and other communities.

Chemical Analysis Services The provided services of chemical analysis include: (i) determination of the chemical compound, (ii) analysis of food, feed, water, micro-biology, (iii) environmental analysis (e.g. ambient air, air emissions, etc.), (iv) analysis of metal content; (v) analysis of antioxidant, anti-diabetic, (vi) others. This service analysis is supported with tools such as 500 MHz NMR, FTIR, LCMS, GCMS, GC, AAS, HPLC, Spectrofotometer, PSA, etc.

Indonesian Journal of Applied Chemistry (ISSN 0853-2788) RCChem through this division also manage Indonesian Journal of Applied Chemistry, an accredited journal published biannually. The journal contains selected papers in chemistry fields from researchers in Indonesia. More of detailed informations is available on website http://kimia.lipi.go.id. Contact via email to jkti_ppkimialipi@yahoo.com.

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RECENT RESEARCHES Adsorbent Development in Purification Process of Ethanol-Water System Based on Polymer Developed as an adsorbent material with higher water absorption for bioethanol purification. Bio-Oil Production from Midrib and Empty Fruit Bunches of Palm Oil (EFBPO) by Catalytic Fast-Pyrolysis Process Process of catalytic thermal degradation of a biomass converted into liquid chemical/bio-oil modified into a source of renewable liquid fuels. Glycerol Conversion from Side Product of Biodiesel Production into Synthetic Gas Preparation of solid catalyst and its application for glycerol conversion from side product of biodiesel production into renewable fuel. Polymer Based Anti-Fouling Paints for Marine Coatings Paint for prevent the attachment of marine organisms on wetted materials such as boats, docks, etc. Hybrid Coating as Anticorrosion on Metals Epoxy binder as an anticorrosion coating on metal with superior thermal and mechanical properties. Nanocatalyst Design Based on Natural Zeolite for Fine Chemicals Synthesis from Citronella Oil Nanocatalyst technology by utilizing natural zeolite to improve the competitiveness of Indonesian Citronella oil. Anticellulite Cosmetic from Ginger Extract and Centella asiatica Leaf Derived from natural ingredients, the product is highly secure and proven efficacious to reduce cellulite. With the nano particle size (Âą 100 nm), the product is ready to be absorbed gradually by body. Available in oral and topical dosage, with active ingredient protection (encapsulation). Empty Fruit Bunches of Palm Oil (EFBPO) Utilization for Bioethanol Production Development of second generation bio-ethanol scale of 10 liters per day based on lignocelluloses waste (empty fruit bunches of palm oil) to produce bioethanol with concentrations > 95%.

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RECENT RESEARCHES Microbial Fuel Cell (MFC) This fuel cell is based on local microbe and equipped with an inert electrode. MFC is used to reduce water pollution as well as producing electricity from liquid waste. Second Generation Bioethanol Refineries (G2) Process of making an efficient bioenergy to produce co-products such as fine chemicals, yeast extract, reuse and minimize waste with NaOH Environmental Impact Assessment of Biomass Conversion Process with LCA Approach Calculating the amount of resource consumptions and emissions in all stage processes and evaluating the impact based on inventory analysis results. Wastewater Treatment Processing liquid waste from the laboratories until it reach environmental quality standards or become into process water. DFA III Production and Its Application as a Beverage Supplement for Osteoporosis Prevention DFA III is a low-calorie sweetener which has the potential to prevent osteoporosis, anemia, and lower the risk of colon cancer. DFA III can be applied to a variety of processed food products and pharmaceutical preparations together with calcium source to be developed as supplement/nutraceutical for osteoporosis. We have developed supplement products DFA III in the form of effervescent granules and ginger powder instant for bone health, and it has been through hedonic organoleptic test involving 30 panelists. Development of Functional Food Based Inulin from Dahlia Tubers (Dahlia spp. L) as A Water Soluble fiber (SDF/Soluble Dietary Fiber) for Anticholesterol Inulin fiber from Dahlia tubers was hydrolized enzymatically using endophitic fungi Accremonium sp and Aspergillus clavatus. The hydrolysis product has the potency to bind cholesterol. Development of Functional Food Based on Polysaccharide from Sorghum (Sorghum bicolor L.) for Anticholesteremic This research was carried out to obtain dietary fiber from sorghum whole grain through enzymatic and chemical hydrolisis. Dietary fiber has been found consist of soluble dietary fiber and insoluble dietary fiber which indicated anticholesterol function.

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RECENT RESEARCHES Fat Separation Process in Improving The Quality of Gelatin from Chicken Shank and Cow Skin and Its Application as a Carrier For Supplements and Functional Beverages as an Anticholesterol Inulin Fiber Separation fat from gelatine of skin leather and shanks were conducted with various acetic acid concentration. Formulation of the gelatine with inulin produced food supplement and functional drink for lowering cholesterol. Development of Functional Food with Inulin Fortification In this research, functional foods of beans yogurt was fortified with inulin to increase the dietary fiber content of yogurt product. L-Theanine Production Techniques of Green Tea (Camellia sinensis) as Antistress Compounds through Multi Filtration System The separation process of L-Theanine from green tea (Camellia sinensis) through multi filtration system was carried out to gain concentrate or green tea granule rich L-Theanine as natural antistress agent. Vinegar from Cashew Fruit Cashew fruit was used as raw material for vinegar making through fermentation process by Saccharomyces cerevisiae followed by Acetobacter aceti with acetic acid content meets the requirement of vinegar product at least 4 % w/v. Research Development and Diversification of Tempe (Ice Cream & Milk) Tempe diversification was conducted for broadening the use of tempe. This research produced processed tempe products such as tempe ice cream (patented) and tempe milk. Utilization of Endemic Legumes in Making Functional Foods and Flavors of Vegetable Broth Vegetable broth contains meat analog flavor (meatlike-flavor) obtained by fermentation process of green beans by Rhizopus C1 as seasoning. melamine, polyaromatic hydrocarbon buffer pH, conductivity of electrolyte, exhaust emission gas, and greenhouse gas. The reference materials is traceable to International System units and is certified based on ISO Guide 34 and 35. The reference materials can be used by testing laboratory to validate their results in order to increase the quality assurance.

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RECENT RESEARCHES Potency of Breadfruit Leaves (Artocarpus Altilis) for Cardiovascular Disease Extract contains standardized flavonoids & phytosterols, used for cardiovascular medicine in peroral tablet form. Artemisinin and Derivative Products for Antimalarial Drug Antimalarial drug derived from the tropical plant Artemesia annua L Asteraceae consists of artemisinin and its derivative compounds i.e. dihidroartemisinin, artemether, arteeter, and artesunate. Natural Products for Dengue Antivirus Natural materials from standardized herbal extracts of Peperomia pelucida and Pterocarpus indicus leaves were researched to encounter diseases caused by dengue virus. In vitro and in-vivo tests were performed to check its activity and security. Design and Biotransformation of Eugenol Dimer and Its Derivatives toward Estrogen Receptors as Breast Cancer Drug This research resulted eugenol synthesis compound which is directed as raw material of anticancer, antioxidant, and antiinflammatory drugs. Study of Anticancer Active Compounds Potential from Mekongga Forest Trees Isolation and identification of active anticancer compounds from the leaves of Macaranga mappa, Koordersiodendron pinnatum, Artocarpus elasticus, and Tetrameles nudiflora to acquire two new anticancer compounds. Development of Certified Reference Materials Development of certified reference materials for metals, anion, pesticide residue, benzoate, melamine, polyaromatic hydrocarbon buffer pH, conductivity of electrolyte, exhaust emission gas, and greenhouse gas. The reference materials is traceable to International System units and is certified based on ISO Guide 34 and 35. The reference materials can be used by testing laboratory to validate their results in order to increase the quality assurance.

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GALLERY

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GALLERY

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INDONESIAN INSTITUTE OF SCIENCES

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Contact Address PUSAT PENELITIAN KIMIA LIPI Kawasan PUSPIPTEK Serpong, Tangerang Selatan, Indonesia Postal Code 15314 Phone +62-21-7560929, Fax +62-21-7560549 Web http://kimia.lipi.go.id, e-mail rcchem@mail.lipi.go.id

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Booklet 2014  
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