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New Sutdy on Astragaloside IV guidechem, Astragaloside IV,84687-43-4 Astragaloside IV, the dried root of a low shrub, has been widely prescribed in traditional Chinese medicine for the treatment of cardiovascular disorders. Over 25% of the 90 recipes in the 2010 edition of the Chinese Pharmacopoeia for cardiovascular diseases (CVD) contain Astragalus membranaceus Bunge. Astragaloside IV is one of the main active compounds of Astragalus membranaceus Bunge. Experimental studies from several laboratories,have provided abundant evidence demonstrating the explicit cardiovascular-protective effects of Astragaloside IV. In vivo animal studies have shown that this chemical is protective against isoproterenol-induced myocardial injury and isoproterenol-induced cardiac hypertrophy , elevates coronary blood flow and reduces the size of myocardial infarcts after coronary occlusion. In vitro experiments suggested that Astragaloside IV could improve post-ischemic heart function and ameliorate reperfusion arrhythmias, attenuate hypoxia-induced cardiomyocyte damage , and relax smooth muscle in the aorta from both normal rats and stroke-prone spontaneously hypertensive rats. It could also enhance the activity of antioxidant enzymes; reduce the levels of phenylephrine and angiotensin II, block calcium influx and intracellular calcium release, and stimulate the NO窶田GMP pathway. It also exhibits significant anti-inflammatory effects in vivo. Studies suggest, amongst others, that astragalus root extract and astragaloside IV have the following properties : Anti-inflammatory as shown in certain animal models. The ability of astragaloside IV to stem inflammation of the airways in chronic asthma has been reported in studies on mice. Immunostimulant : acting through a number of different pathways, especially by increasing the number of stem cells in the spinal cord and lymphatic tissue and encouraging them to develop into active immune cells and by stimulating production of immunoglobulins and macrophages. Antiviral: inhibiting replication of certain viruses such as coxsackie, responsible for myocarditis (inflammation of the heart muscle). In both animal and human studies, they were shown to stimulate endogenous interferon production and to maximise its effect on viral infections. Neuroprotective: in traditional Chinese medicine, astragalus root extract is used to treat neurodegenerative diseases. One study demonstrated the capacity of astragaloside IV to protect dopaminergic neurons (progressive degeneration of dopaminergic neurons leads to the development of Parkinson's disease).
Antibacterial: as demonstrated by in vitro studies on Shigella dysenteriae, Streptococcus haemolyticus, Diplococcus pneumoniae and Staphylococcus aureus. Antioxidant: inhibiting lipid peroxidation by 40% in vitro. These antioxidant properties may go some way to explaining the cardio- and neuro-protective effects of astragalus and astragaloside IV. Cardioprotective: with studies highlighting health benefits for patients with congestive cardiac insufficiency and angina pectoris. Astragalus extracts have a cardiotonic effect. Inhibitory against formation of the AGEs (advanced glycation end- products) involved in neuropathic complications of diabetes. Protective: against the toxic effects of chemotherapy. Astragalus extract boosts resistance to the immunosuppressive effects of chemotherapy drugs by encouraging macrophages to product interleukin 6 and tumour necrosis factor. With so many beneficial properties, particularly immunostimulant, anti-inflammatory, antioxidant and anti-glycation, astragaloside is a truly essential anti-aging supplement. Its exceptional properties are due to astragaloside's specific ability to activate telomerase, thus slowing down the shortening of telomeres, and extending cell lifespan. Shortening of telomers is associated with cellular ageing and the development of age-related diseases. The shortest telomers have been observed in octogenarians. Research also suggests that individuals aged 60 or older with the shortest telomers appear to be at significantly higher risk of death from infectious disease or heart attacks. Conversely, studies have shown that stimulating telomerase may significantly increase cell lifespan. Want to learn more information about Astragaloside IV , you can access the guidechem.com.
Published on Dec 9, 2013
Astragaloside IV is one of the main active compounds of Astragalus membranaceus Bunge. Experimental studies from several laboratories,have p...