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Mariangel P茅rez C.I.: 25.563.490

P.V.P. 53,50 Edici贸n Mensual


The Down syndrome (SD) it is a genetic dysfunction caused by the presence of an extra copy of the chromosome 21 (or a part of the same one), instead of both habitual (trisomía of the couple 21)

Characterized by the presence of a variable grade of cognitive discapacidad and some peculiar physical features that give him a recognizable aspect. It is the most frequent cause in congenital psychic cognitive discapacidad and it owes their name to John Langdon Haydon Down that was the first one in describing this genetic alteration in 1866, although he/she never ended up discovering the causes that produced it. In July of 1958 a called investigating youth Jérôme Lejeune discovered that the syndrome is an alteration in the aforementioned couple of chromosomes.


The Down syndrome takes place more for the appearance of a chromosome in the couple 21 original (three chromosomes: “trisomía” of the couple 21) in the cells of the organism. The scientific nomenclature for that chromosomal excess is 47, XX,+21 or 47, XY,+21; as it is a woman or of a male, respectively. Most of people with this syndrome (95%), they owe the chromosomal excess to an error during the first division meiótica (that for the one that the gametes, ova or sperms, lose half of their chromosomes) calling you to this variant, “free trisomía” or to regulate. The error owes himself in this case to an incomplete disjunction of the genetic material of one of the progenitors. (In the habitual formation of the gametes the couple of chromosomes separates, so each progenitor only transmits the information of one of each couple's chromosomes. When the disjunction doesn't take place both chromosomes they are transmitted). they are not known with accuracy the causes that originate the erroneous disjunction. As in other similar processes they have intended hypothesis multifactoriales (environmental exhibition, cellular aging…) without it has been possible to establish any direct relationship between any causing agent and the appearance of the trisomía. The only factor that presents a stable statistical association with the syndrome is the maternal age, what seems to support the theories that make stress in the deterioration of the genetic material with the step of the time. In approximately 15% of the cases the extra chromosome is transmitted by the sperm and in 85 remaining% for the ovum


The cells of the human being possess each one in their nucleus 23 couples of chromosomes. Each progenitor contributes to his descendant half of the genetic information, in form of each couple's chromosome. 22 of those couples are denominated autosomas and the last one corresponds to the sexual chromosomes (X or AND). Traditionally the couples of chromosomes are described and they name in function of their size, of the couple 1 at the 22 (of bigger to smaller), more the aforementioned couple of sexual chromosomes. The chromosome 21 are the smallest, in fact, for what should occupy the place 22, but an error in the convention of Denver of the year 1960 that the Down syndrome assigned to the couple 21 it has lasted until our days, staying for practical reasons this nomenclature. The chromosome 21 contain 1% of the genetic information of an individual approximately in something more than 400 genes, although today in day it is only known accurately the function of some few ones.


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TRIUNO NEO-BARK HEMISPHERE LÍMBICO PROCESSES REASONING INTUITION LANGUAGE RIGHT SYSTEM


Aquarius (01/20 - 02/18) Love: Your passion will be rewarded. It is time to stop this in the past. Stroke: Maybe you should think about starting your own business? Health: You'll feel full of energy during the next month. Money: Do not be so hard to negotiate when: scare your contractors and miss great opportunities.

Taurus (04/20 - 05/20) Love: Keep your eyes open and not to reject all offers. Stroke: It is time to organize your tasks according to the priority of them. Health: Finally, it shows a high susceptibility to colds and flu. Money: Do not be too happy about your new situation.

Pisces (02/19 03/20) Love: Re-consider its options before making a final decision. Stroke: The ideas will become clearer when you see inside your heart. Health: Your health is good, but be careful when traveling. Money: There are strong indications that you have achieved total financial security.

Gemini (05/21 - 06/21) Love: Do not be so hard with your past, leave the hate behind. Stroke: Not face serious turbulence in your career this month. Health: Stop eating junk food. Money: Finally, you can spend more money on entertainment.

Aries (03/21 04/19) Love: Say what you think without feeling guilty is a skill that must still be developed. Stroke: Now is the time to believe in yourself and succeed: Imagine living the life you want and this will happen. Health: Rests appropriately if they have the opportunity. Money: You need money aside for something unexpected.

Cancer (06/22 - 07/22) Love: Your passion will be recognized and rewarded appropriately. Stroke: Your hours will change when adjusted as you learn to organize better. Health: You should think about losing some weight. Money: Spend your money so extravagant


Leo (07/20 - 08/20) Love: Keep your eyes open and not to reject all offers. Stroke: It is time to organize your tasks according to the priority of them. Health: Finally, it shows a high susceptibility to colds and flu. Money: Do not be too happy about your new situation.

Sagitario (12/20 - 01/18) Love: Your passion will be rewarded. It is time to stop this in the past. Stroke: Maybe you should think about starting your own business? Health: You'll feel full of energy during the next month. Money: Do not be so hard to negotiate when: scare your contractors and miss great opportunities.

Virgo (09/21 - 10/21) Love: Do not be so hard with your past, leave the hate behind. Stroke: Not face serious turbulence in your career this month. Health: Stop eating junk food. Money: Finally, you can spend more money on entertainment.

Escorpion (02/19 - 03/20) Love: Re-consider its options before making a final decision. Stroke: The ideas will become clearer when you see inside your heart. Health: Your health is good, but be careful when traveling. Money: There are strong indications that you have achieved total financial security.

Libra (11/22 12/22) Love: Your passion will be recognized and rewarded appropriately. Stroke: Your hours will change when adjusted as you learn to organize better. Health: You should think about losing some weight. Money: Spend your money so extravagant

Capricornio (03/21 - 04/19) Love: Say what you think without feeling guilty is a skill that must still be developed. Stroke: Now is the time to believe in yourself and succeed: Imagine living the life you want and this will happen. Health: Rests appropriately if they have the opportunity. Money: You need money aside for something unexpected.


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