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Keratoconus in Four Siblings Including Two Monozygotic Twins González-Méijome JM 1, Peixoto-de-Matos SC 2, Soares AS 1, Queiros A 1, Jorge J 1 1 2

Clinical & Experimental Optometry Research Lab. University of Minho, Braga, Portugal. Óptica Queiros Lda. Povoa de Lanhoso, Portugal

Purpose: The purpose of this communication is to present a case series of four siblings presenting clinical signs or clinical suspect of keratoconus. Methods: Four cases are reported including topographic, refractive and visual examination as well as slit lamp examination. These series includes two monozygotic twins presenting different degrees of manifestation of topographical signs. Results: The more advanced case and first to be diagnosed was present in the left eye of the male sibling, needing a rigid gas permeable lens to correct irregular astigmatism. The second case diagnosed and reported was one sister with history of monthly disposable soft toric lens to compensate a presumed initially regular astigmatism. The remaining two cases being the older sister and one of the monozygotic twins presented the less noticeable signs and symptoms, with no confirmation of the pathology in the former case but warranting a close follow-up due to the asymmetric corneal topographies between both eyes as well as between the flatter superior and steeper inferior corneal areas. Conclusions: This case series highlights several aspects of presentation of keratoconus disease that are important for the clinical optometrist and ophthalmologist. First, family cases of keratoconus can present in such a singular pattern as reported here with at least four in six siblings being affected, including two monozygotic twins.



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CIOCV'09 Proceedings  

Proceedings for the International Conference of Optometry and Visual Science 2009 (CIOCV'09). University of Minho, Braga, Portugal