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Joint Action News Hayley Jumps for Joint Action On Friday 21st June, Hayley Oliver faced a challenge that would scare most people. Hayley decided to do a bungee jump to raise funds for Joint Action. Hayley, Finance Assistant for the British Orthopaedic Association (BOA), decided to do the jump because she can see from behind the scenes that Joint Action makes a difference and also has a family member who has had orthopaedic intervention. Hayley said: “When I first volunteered to take part in a bungee jump for Joint Action I was extremely excited, this was something that most people say they want to do but never seem to get around to it. With more than eight weeks until the jump was due to happen I immediately began fundraising. I agreed with Lauren Rich on a target of £300. The nearer we got to ‘jump day’ the more the nerves kicked in!” The jump itself was from a 160ft crane over an air cushion which was situated in a car park at the O2 in Greenwich. Hayley continued: “By event day I had raised well over my target - an amazing £538.00! • Text AUTM77 £10 to 70070

This amount played a big part in convincing me to go through with the jump. When I arrived at the O2 I had a number of supportive family, friends and work colleagues there to cheer me on. Even the crew members were surprised at the 18 people who were chanting my name. Once in the crane at 160ft, staring at the ‘tiny ants’ on the ground, the nerves started to get to me. I somehow found the strength to throw myself into thin air thinking of all the people who had supported me in sponsorship, the people on the ground who stood in the rain to witness the jump and all the people who rely on the fundraising. This was a truly fantastic experience that I thoroughly enjoyed and would recommend to everyone; especially if you can raise money for a worthy charity like I did.” Witnessing Hayley’s jump was a great experience for those on the ground; the sheer determination Hayley showed when boarding the crane, and the joy in her face when falling towards the ground.

Thanks Hayley! What a star! Joint Action News – October 2013

Malcolm’s 250 Mile Walk

Joint Action Grants A


Malcolm Weaver made it his mission to walk a massive 250 miles from Banbury to Barnstaple to raise money for Joint Action. Malcolm, a keen walker who had an elbow replacement, took 16 days with a 32lb rucksack on his back to complete the walk and thoroughly enjoyed the experience. Malcolm raised £552.19 and said that the blisters were worth it! Thanks Malcolm and to those who supported you – an amazing achievement and we’re extremely grateful!

In June, following our annual Research Call, we awarded funding to four very worthy research projects. These projects were scored by our Grants Committee and two independent peer reviewers per application.

Ines Reichert – London

Ines and her team will be researching whether an overproduction of the protein Sclerostin (made naturally by bone cells) contributes to skeletal complications in patients with Diabetes.

Herbert Gbejuade – Bristol

Herbert will be looking into various combinations of antibiotics and bone cement to evaluate new and effective means of preventing implant infections after hip revisions.

Craig White – South Tees

Craig will be doing a pilot study on whether the administration (topically not orally) of Tranexamic Acid (a drug that reduces blood loss) will reduce blood loss and subsequent blood transfusion significantly after hip fracture operations.

Paul Hindle – Edinburgh

Paul is researching whether fat found within the knee is a good source of stem cells for cartilage repair. • Text AUTM77 £10 to 70070

Joint Action News – October 2013

In The Spotlight

Miss Harriet Branford-White (Grant Recipient 2010) University of Oxford Research: To identify mechanisms which cause resistance to treatment in Ewing’s Sarcoma patients. Summary: Harriet’s work has been specifically

focussed on Ewing’s Sarcoma, an aggressive bone tumour most common in teenagers and young adults. Many of the treatments available are prolonged and cause significant side effects such as infertility and secondary cancers. Because of this, there is a rapid need for the discovery of targeted and specific treatments for Ewing’s Sarcoma patients to move from the lab bench to the bedside. Previous research has shown that in Ewing’s Sarcoma cells there is excessive activity of a pathway called the insulin-like growth factor (IGF) pathway, which drives cancer cells to divide and grow. Logically using a drug to block this pathway, and IGF-1 Receptor Inhibitor (IGF1R) would be beneficial to patients with Ewing’s Sarcoma, however when such treatment has been used in clinical trials, only a small proportion of patients respond. This suggests that there are other pathways, or mechanisms in play causing patients to be resistant to treatment but has yet to be fully explained.

Sarcoma may be altered and therefore more active than it should be, aiding the cells in dividing and growing. By identifying this, it could be another clue to understanding the complicated interplay of all the different factors which may cause tumour cells to become resistant to treatments.

Benefit to patients: Despite advances

in surgical techniques and chemotherapy a proportion of patients with Ewing’s Sarcoma do not respond to available treatments. Through this research, Harriet interrogated further mechanisms which could prevent the tumours from responding. Her experimental findings will be expanded and validated further as part of a European Phase II clinical trial which has started in Oxford for patients with recurrent Ewing’s Sarcoma.

The aim of this study was to identify such mechanisms which contribute to resistance in Ewing’s Sarcoma patients. lucky to be in this fairly My grant was £50,000. I am see work which I have unique position to be able to Early data suggests that in some cell bench directly to the been involved in taken from the lines, a protein in the cell which helps l to Joint Action and to bedside and I am very gratefu in the signalling pathway and has not this to occur. you for the support in helping previously been implicated in Ewing’s • Text AUTM77 £10 to 70070

Joint Action News – October 2013

A Saturday Swim for 3 Fundraising Swimmers On 31st August, three swimmers took on a 1 mile swimming challenge – The British Gas Great London Swim – at Royal Victoria Dock to raise money for Joint Action. Jaco van Zyl has been an amputee for the last 11 years and was keen to fundraise after hearing about the event through a work colleague. “My reason for choosing Joint Action was that it’s a charity to which I can relate. I can empathise with others that have trouble with mobility and know what a tremendous positive impact it can make in someone’s life when you have the right treatment, equipment and support; so that Jaco van Zyl

you can function as normally as possible and do almost everything and anything you want to do in your life, without limitation.” Frances Sudera who works at St Anthony’s Hospital took on the challenge because her mum, a retired GP, has had both hips and knees and a wrist replaced since her retirement. Joanna Skeels, at 24 years old, had to have a right hip replacement. However, she’s fighting fit and took on the Great London Swim with gusto. Joanna Skeels post swim

Charity Flowers Are you someone who likes to give flowers to your loved ones and friends to mark a celebration or as a thank you? If you do then you can also help Joint Action at the same time. All you need to do is visit www., find the flowers you like and then select Joint Action from the list of charities. 15% of the retail price will be sent to Joint Action by Charity Flowers. So simple and at no extra cost to you. • Text AUTM77 £10 to 70070

Joint Action News – October 2013

Joint Action News - October 2013  

This newsletter focuses on our fundraisers, our latest funded projects and another instalment of "In The Spotlight".

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