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Fast Facts Johns Hopkins technology offerings

Johns Hopkins University Technology Transfer office ADVAMED 2013: tHE MEDTECH CONFERENCE


Johns Hopkins technology transfer

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TABLE OF CONTENTS

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Paul Bottomley, Ph.D.

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Jeff Geschwind, M.D.

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Jin Kang, Ph.D.

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Xingde Li, Ph.D.

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Elliot R. McVeigh, Ph.D.

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Susumu Mori, Ph.D.

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Hien Nguyen, M.D., FACS

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jeffrey siewerdsen, Ph.D.

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Dan Stutman, Ph.D. and Michael Finkenthal, Ph.D.

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Peter Van zijl, Ph.D.

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richard wahl, M.D., FACR

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Clifford Weiss, M.D.

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Inventor Fact Sheets


Paul Bottomley, Ph.D.

Russell H. Morgan Professor, Department of Radiology Director, Division of Magnetic Resonance Research

Biography

licensing Associate Ami Gadhia Portfolio Director Phone: 410-516-6515 Email: agadhia2@jhmi.edu

Paul A. Bottomley, Ph.D., received his Ph.D. in physics in 1978 from the University of Nottingham, UK. There, he was a member of the first original team to developed the first human MRI scanner. He was a research associate at The Johns Hopkins University from 1978–1980 and a physicist at GE Research and Development Center from 1980–1994. He is currently a Russell H. Morgan Professor and director of the division of MR research of the Russell H. Morgan Department of Radiology and Radiological Sciences and The Johns Hopkins University. He is the recipient of several awards, including the gold medal of the Society of Magnetic Resonance in Medicine, 1989; Coolidge Fellowship and Medal, GE Company, 1990; gold, silver, and bronze patent medals, GE Company. He developed the original techniques for performing localized nuclear magnetic resonance (NMR) spectroscopy, and has ongoing clinical research studies employing phosphorus (31P) to study energy metabolism in humans. His research specialties include in vivo NMR, MRI, tissue relaxation times, localized NMR spectroscopy, human cardiac NMR spectroscopy, interventional MRI, and MRI safety.

Research Interests Dr. Bottomley’s lab is working to optimize of surface MRI detectors to maximize the SNR, including the development of new strip-detectors, as well as tiny catheter-based MRI detectors for internal/intravascular use, and “MRI endoscopy.” Of central interest at the moment—following development with Dr. Clifford Weiss in Cardiology of a method to measure metabolic flux—is the observation of a shortfall in energy supply in patients with heart failure.

Technology Portfolio

• C11466: One-Step MRI Method to Increase Image Contrast • C11463: Real-Time High Dynamic Range RF Power Monitor • C11462: Novel Method of Performing Localized Magnetic Resonance

Spectroscopy • C09885: Methods & Applications of Rapid Magnetic Resonance Sensitive to Longitudinal Relaxation Times • C04541: Multi-turn Element RF Coil Array for Multiple Channel MRI • C03771: Practical Tunable Planar and Cylindrical Multi-element Magnetic Resonance Detector Arrays

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Jeff Geschwind, M.D.

Professor of Radiology, Surgery and Oncology Director of the Division of Vascular and Interventional Radiology The Johns Hopkins University School of Medicine Director of the Interventional Radiology Center The Johns Hopkins Hospital

Biography Jean-Francois (Jeff) Geschwind, M.D., received his medical degree from Boston University School of Medicine in 1991. He completed his residency training as a Research Scholar (sponsored by the NIH) in Diagnostic Radiology at the University of California at San Francisco (UCSF) in 1996, where his research focused on cardiac magnetic resonance imaging. Dr. Geschwind completed his training in Vascular and Interventional Radiology at Johns Hopkins and joined the faculty in 1998 as an assistant professor. In 2002, he was appointed Director of the Division of Vascular and Interventional Radiology and of the Interventional Radiology Center at the Johns Hopkins Hospital, and in 2007 was promoted to Professor of Radiology, Surgery and Oncology at the Johns Hopkins University School of Medicine.

licensing associate Heather Bakalyar Portfolio Director Phone: 410-516-6653 Email: hbakaly1@jhmi.edu

He has won numerous awards, including the Alexander Margulis Society Excellence in Research Award from UCSF in 1995, the Annual Memorial Award from the Association of University Radiologists in 1994, the Dr. Gary J. Becker Young Investigator Award from the Society of Interventional Radiologists in 2000, and the Merit Award from the American Society of Clinical Oncology.

Research Interests Dr. Geschwind has focused his clinical expertise on treating hepatic cancer and other malignancies. He and his colleagues are currently working on a new approach using drugs designed to specifically block tumor metabolism in cancer cells. Dr. Geschwind and colleagues have also continued to improve current therapies for patients with liver cancer, in particular catheterbased therapies such as chemoembolization and radioembolization. He is considered a key opinion leader in the field of liver cancer and has received numerous foundation, industry and federal grants for his research in the field.

Technology Portfolio • C11368: Targeted Non-Chemotherapeutic for Hepatocellular Cancer • C10201: Method of Synthesis of Chemospheres and Chemogel, Hydrogel

Embolic Particles and Gel for Locoregional Delivery of Therapeutic Agents and Immunoisolation of Cellular Therapeutics

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inventor Fact Sheets


Jin Kang, Ph.D.

Professor and Department Chair Electrical and Computer Engineering

Biography

licensing Associate Nestor Franco Licensing Associate Phone: 410-516-5654 Email: nfranco6@jhmi.edu

Jin U. Kang, Ph.D., is a professor and Chair of the Electrical and Computer Engineering Department at The Johns Hopkins University. He earned a BS in physics from Western Washington University, and both MS and Ph.D. degrees from the School of Optics (CREOL) at The University of Central Florida. Prior to joining Johns Hopkins, he was a research scientist with the U. S. Naval Research Laboratory in Washington DC. He has developed various fiber sources from single longitudinal mode tunable lasers to mode-locked femtosecond lasers. He was also the first to experimentally demonstrate the existence of several important novel effects and devices including Manakov Spatial Solitons and backward propagating second harmonic generation. He has published more than 100 journal papers and 150 conference publications.

Research Interests Dr. Kang’s research is focused on developing novel fiber optic devices and systems for various applications in medical, communications, and sensors. He conducts experimental/theoretical investigations in the area of photonics and optoelectronics with emphasis on developing novel fiber laser systems and ultrafast optoelectronic devices for applications in military, communications, sensors, and space sciences.

Technology Portfolio • C11649: A Real-Time Noise Subtraction for FD-OCT using the GPU • C11485: New Methods for Intraocular Laser Therapy Using Quantum Cascade Laser (QCL) • C11396: Fiber-Optic Confocal Microscope that Compensates for Breathing and Blood Flow • C11386: Fiber Bundle Based Endoscopic Microscope System • C11378: OCT-Based 4D View for Micro-Surgery Procedures • C11377: A Novel Graphics Processing Unit (GPU) that Up-Grades the Signal for FD-OCT • C11324: Full-range Complex-conjugate-free Endoscopic Spectraldomain Optical Coherence Tomography • C11161: 1-D Surface Tracking and Motion Compensation Hand-held Microsurgical Tool System Based on Dynamic Common-Path Optical Coherence Tomography Sensor

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Xingde Li, Ph.D.

Professor, Biomedical Engineering Professor, Electrical and Computer Engineering The Johns Hopkins University

Biography Xingde Li, Ph.D. received his bachelors of science degree in physics from the University of Science and Technology of China, and his doctoral degree in physics from the University of Pennsylvania, and postdoctoral training from MIT. He is currently a full professor in the Department of Biomedical Engineering at Johns Hopkins University. He also serves on the editorial boards for IEEE Transactions on Biomedical Engineering, Biomedical Optics Express (OSA), IntraVital Microscopy (Landes Biosciences), and Light: Science and Applications (Nature Publishing Group and CIOMP) plus several other international journals in biophotonics.

Research Interests Dr. Li’s research interest centers on the development of cutting-edge and translational biophotonics technologies that interface and bridge basic engineering research and medical diagnosis and intervention. The research and training involves vertical integration of multiple disciplines, including (but not limited to) optics, electrical engineering, micro-nano technology, biology and clinical medicine. The ultimate goal of his research is to transform the capability of disease detection at early, manageable stages, monitoring therapeutic effects and treatment outcomes, and guiding interventions. The technologies also offer new opportunities for basic research in exploring new frontiers of disease mechanisms, brain function, biomarker discovery and integrated diagnosis and therapy. Some specific research interests include:

licensing associate Jeffrey James Licensing Associate Phone: 410-516-4560 Email: jjames26@jhmi.edu Heather Bakalyar Portfolio Director Phone: 410-516-6653 Email: hbakaly1@jhmi.edu

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Optical Coherence Tomography (OCT) Multiphoton Endomicroscopy Label-free Mass-spectrometry Imaging (MSI) NIR Fluorescence Imaging Functional Nanocapsules and Nanoparticles for Molecular Imaging Noninvasive Cancer Detection, Infection and Inflammation Detection, Preterm Birth Assessment, Wound Healing Imaging and Surgical Guidance • In vivo Cellular Metabolism Imaging, Brain Function Imaging

Technology Portfolio • C12395: Mass Spectrometry Imaging of Glycans from Tissue Section (MSIG)

• C12515: Two-dimensional MEMS Scanning Apparatus

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inventor Fact Sheets


Elliot R. McVeigh, Ph.D.

Massey Professor and Director Department of Biomedical Engineering Johns Hopkins University School of Medicine

Biography

licensing Associate Ami Gadhia Portfolio Director Phone: 410-516-6515 Email: agadhia2@jhmi.edu Heather Bakalyar Portfolio Director Phone: 410-516-6653 Email: hbakaly1@jhmi.edu

Elliot McVeigh, Ph.D., received his undergraduate degree in Physics from the University of Toronto in 1984. In 1988 he obtained his Ph.D. doing MRI research in the Department of Medical Biophysics at University of Toronto. Immediately following his Ph.D., Dr. McVeigh joined the faculty of Radiology at The Johns Hopkins University School of Medicine, working with Elias Zerhouni to develop a research program in cardiac MRI.

Research Interests In 1991 Dr. McVeigh founded the Medical Imaging Laboratory in the Department of Biomedical Engineering as part of a Whitaker Development Award. Many novel MR imaging techniques were developed during this period: myocardial tagging for evaluating local muscle contraction, myocardial perfusion estimates with dynamic imaging of contrast injections, and late enhancement imaging to clearly image myocardial infarction. These techniques form the foundation of the modern cardiac MRI exam. Dr. McVeigh’s laboratory also demonstrated the ability of MRI to evaluate the benefit of Cardiac Resynchronization Therapy (CRT) in the failing heart; these studies were seminal in understanding how CRT should be used.

Technology Portfolio • C11695: SQUEEZ – New Technique for Cardiac Function Measurement • C03160: Method for Measuring Myocardial Motion

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Susumu Mori, Ph.D. Professor, Department of Radiology Director, Center for Brain Imaging Science

Biography From 1991 - 1996, Susumu Mori, Ph.D., worked on his Ph.D. in Biophysics at The Johns Hopkins University School of Medicine under the supervision of Dr. Peter van Zijl. He then did a postdoctoral fellowship in the department of radiology at Johns Hopkins, becoming an assistant professor in radiology at The Johns Hopkins University School of Medicine in 1997. He became an associate professor at Johns Hopkins in 2002, and a professor in 2006. He has received several awards for his work, including the 2001 Young Investigator’s Award from the Human Frontier Science Foundation, the 1996 Martin and Carol Macht Research Prize, from Johns Hopkins University, and the 1994 Rabi Award from the International Society of Magnetic Resonance in Medicine

Research Interests

licensing Associate Ami Gadhia Portfolio Director Phone: 410-516-6515 Email: agadhia2@jhmi.edu

Dr. Mori is developing new data acquisition and analysis technologies of magnetic resonance imaging to study the brain anatomy. Diffusion tensor imaging and microimaging techniques have been the main focus of the technology development. The new techniques have been applied to various types of brain research including normal brain development and aging as well as diagnosis of brain diseases including Alzheimer’s disease, Huntington’s disease, and developmental disorders. The technologies have also been applied to high-resolution imaging of developing mouse brains and phenotype characterization. His lab is currently working on automated MR image analysis.

Technology Portfolio • C03471: Fiber Reconstruction Method using Data Acquired by Magnetic Resonance Imaging

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inventor Fact Sheets


Hien Nguyen, M.D., FACS

Director, Comprehensive Hernia Center Assistant Professor of Surgery, School of Medicine Associate Medical Director, Center for Bioengineering Innovation and Design (CBID), Whiting School of Engineering

Biography

licensing Associate Nestor Franco Licensing Associate Phone: 410-516-5654 Email: nfranco6@jhmi.edu

Hien Nguyen, M.D., FACS, is the director of the Johns Hopkins Comprehensive Hernia Center, an assistant professor of surgery in The Johns Hopkins University School of Medicine and an associate medical director for the Center for Bioengineering Innovation and Design (CBID) in The Johns Hopkins Whiting School of Engineering. He earned his medical degree at The University of California Davis School of Medicine. He completed training in general surgery at The University of California San Francisco East Bay, followed by a fellowship in advanced laparoscopic and bariatric surgery at The Johns Hopkins University School of Medicine. Board-certified in general surgery, Dr. Nguyen is an expert in single-incision surgery, robotic surgery and laparoscopic bariatric surgery (which includes Roux-en-Y gastric bypass, adjustable gastric bands, sleeve gastrectomy and duodenal switch). He was instrumental in helping to establish the single-incision approach for laparoscopic surgery at The Johns Hopkins Medical Institutions.

Research Interests Dr. Nguyen research interests include clinical outcomes in hernia surgery, critical care medicine, bariatric surgery and metabolic syndrome. He specializes in minimally invasive surgery and his surgical practice involves the repair of complex hernias, abdominal wall reconstruction, as well as bariatric surgery. His FastStitch device has won many accolades, including a grant from the National Collegiate Inventors and Innovators Alliance, an award from the Abell Foundation at the 2012 Annual Joint Meeting of the Johns Hopkins Alliance for Science and Technology Development and the University of Maryland, Baltimore Commercial Advisory Board, and finished first place in business competitions at the University of Maryland, University of California, Irvine and the ASME Innovation Showcase.

Technology Portfolio • C11888: FastStitch: The Future of Suture • C11660: Keystone Precision Surgical Instruments: An Innovation in Design and Performance

• C11623: Time-saving Laparoscopic Lens Cleaning Tool

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Jeffrey H. Siewerdsen, Ph.D. Professor, Departments of Biomedical Engineering and Computer Science in the Russell H. Morgan Dept. of Radiology Founder, I-STAR Lab

Biography Jeff Siewerdsen, Ph.D., founded the I-STAR Lab as a collaborative endeavor among technical disciplines (engineering and physics) and clinical disciplines (radiology, surgery, and radiation therapy). He is primary faculty in biomedical engineering and the principal investigator on topics of image quality and cone-beam CT applications in diagnostic and image-guided procedures. He leads a program of interdisciplinary research spanning projects in medical imaging physics, diagnostic radiology, and image-guided interventions.

Research Interests Dr. Siewerdsen’s research involves the development of new imaging technologies and the translation of new imaging methods to diagnostic and image-guided procedures. His emphasis is in advanced x-ray imaging techniques, including cone-beam CT, tomosynthesis, and dual-energy imaging. Dr. Siewerdsen’s laboratory has offered numerous advances in the field of medical imaging, including the development of cone-beam CT for image-guided radiation therapy and surgery; the design and implementation of systems for ORs of the future; and the development of high-performance dual-energy x-ray imaging techniques for diagnostic and image-guided procedures. His research program fosters a highly collaborative, multidisciplinary environment of medical physicists, engineers, computer scientists, radiologists, radiation oncologists, and surgeons. He collaborates with experts in surgery, radiation therapy, and radiology guides to accelerate the translation of new technologies into early clinical applications. Central to Dr. Siewerdsen’s research are issues of basic imaging physics, quantitative description of multi-dimensional imaging performance and imaging task, and the development of novel multidimensional imaging technologies.

licensing Associate Nestor Franco Licensing Associate Phone: 410-516-5654 Email: nfranco6@jhmi.edu

Technology Portfolio • C11994: Information Source Mapping in Prior-Image-Based Reconstruction

• C11839: Tomographic Reconstruction Using Prior Images • C11523: Accurate Image Registration Method for Anatomy Changes Between Scans

• C11404: Novel Mathematical Model for CT Image Reconstruction

• C11019:Mountable “On-Board” Surgical Navigation and Tracking

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System

inventor Fact Sheets


Dan Stutman, Ph.D.

Principal Research Scientist Department of Physics and Astronomy The Johns Hopkins University

Biography Dan Stutman received a M.S. in Engineering Physics from the Bucharest University, Romania in 1985 and a Ph.D. in Physics from the Racah Institute of Physics of the Hebrew University, Jerusalem in 1994. In 1996, after completing two years of postdoctoral research at Princeton, he became a member of the JHU Plasma Spectroscopy Group, with which he is since.

Research Interests His research interests are in magnetic fusion plasma physics and spectroscopic diagnostics for magnetic fusion.

Michael Finkenthal, Ph.D.

Professor, Department of Physics and Astronomy The Johns Hopkins University

Biography Dr. Michael Finkenthal graduated in 1968 from the Babes – Bolyai University in Cluj (Romania) and received his Ph.D in 1977 from the Hebrew University in Jerusalem. After a period of post doctoral studies in France and USA (at CEA – Fontenay-aux-Roses, and Hopkins and Princeton, respectively), he returned to Israel in 1982. From that date and till 2004 he was at the Hebrew University in Jerusalem, from which he retired in 2004.

Research Interests licensing Associate Emily Williams Licensing Associate Phone: 410-516-7236 Email: ewill100@jhmi.edu

His research interests are in the area of laboratory and astrophysics as well as XUV optics, detectors and sources for plasma, biological and nano-physics applications.

Technology Portfolio • C11639: Next-Generation Imaging System

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Peter van Zijl, Ph.D.

Director, F. M. Kirby Research Center, Kennedy Krieger Institute Research Scientist, Kennedy Krieger Institute Professor, Department of Radiology, The Johns Hopkins University School of Medicine

Biography

Peter van Zijl, Ph.D., graduated cum laude with a master’s degree in inorganic chemistry and continued to obtain a doctoral degree in mathematics and physics. After completing fellowships in nuclear magnetic resonance (Carnegie Mellon University, Pittsburgh) and MRI (National Institutes of Health, National Cancer Institute), he became a research assistant professor at Georgetown University in 1990. In 1992, he was invited to join the department of radiology at The Johns Hopkins University School of Medicine, where he was promoted to associate professor (1992) and professor (1997). In 1999, he became the founding director of the F.M. Kirby Research Center for Functional Brain Imaging at the Kennedy Krieger Institute.

Research Interests

licensing Associate Ami Gadhia Portfolio Director Phone: 410-516-6515 Email: agadhia2@jhmi.edu

Dr. van Zijl’s present research focuses on developing new methodologies for using MRI and Magnetic Resonance Spectroscopy (MRS) to study brain function and physiology. In addition he is working on understanding the basic mechanisms of the MRI signal changes measured during functional MRI (fMRI) tests of the brain. Other interests are in mapping the wiring of the brain (axonal connections between the brains functional regions) and the design of new technologies for molecular MRI such as imaging of proteins and peptides in tumors and tracking of cell migration and gene expression. A more recent interest is the development of bio-organic biodegradable MRI contrast agents. The ultimate goal is to transform these technologies into fast methods that are compatible with the time available for multi-modal clinical diagnosis using MRI.

Technology Portfolio

• C11504: Improved MRI Technique to Evaluate Disease Progression • C11306: Use of non-labeled Sugars in MRI • C10794: Magnetic Resonance Imaging and Spectroscopy of low • • • •

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concentration solutes with exchangeable protons using Label Transfer Modules. Frequency Transfer, Inversion Transfer C04770: Non-invasive MRI Measurement of Tissue Glycogen C04616: New Class of Reporter Genes for MRI Based on Chemical Exchange Saturation Transfer (CEST) C04457: The Use of Cerebralspinal Fluid as Inter-subject Normalization Reference Standard for Magnetization Transfer Weighted Imaging C03948: Magnetic Resonance Imaging and Spectroscopic Imaging of pH

Inventor Fact Sheets


Richard Wahl, M.D., FACR

Professor of Radiology and Nuclear Medicine Director, Division of Nuclear Medicine/PET Vice Chair, Technology and New Business Development Russell H. Morgan Department of Radiology and Radiological Sciences

Biography

licensing Associate Ami Gadhia Portfolio Director Phone: 410-516-6515 Email: agadhia2@jhmi.edu

Dr. Wahl joined The Johns Hopkins University faculty as director of the Division on Nuclear Medicine; director of the Positron Emission Tomography (PET) Center; and vice chair for technology and new business development within the Russell H. Morgan Department of Radiology and Radiological Sciences in 2000. Dr. Wahl is the principal editor of a best-selling imaging textbook, Principles and Practice of Positron Emission Tomography, and co-author of the Atlas of Clinical PET Imaging. He currently serves on the editorial boards of The Journal of Nuclear Medicine; Molecular Imaging and Biology; and Bioconjugates. He has authored more than 220 peer-reviewed manuscripts, has served on several NIH study sections and currently serves on the Medicare Technology Advisory Committee. He has been chairman of the American Board of Nuclear Medicine. Dr. Wahl has received multiple awards including the Berson and Yalow Award; Tetalman Award of the Society of Nuclear Medicine; The Hounsfield Award of the Society of Body CT; Academy of Molecular Imaging Distinguished Scientist Award, and has been honored as the New Horizons Lecturer for the Radiological Society of North America.

Research Interests Dr. Wahl’s primary research has included the diagnosis and treatment of cancer through the use of specifically targeted radiopharmaceuticals. Over the past 20 years, Dr. Wahl has been involved in the development of “smart radiopharmaceuticals”-targeting tumors for therapy and spare healthy tissue. He is a leading expert in PET, and was cited by the Academy of Molecular Imaging as the first person in the United States to apply PET technology to accurately diagnose a broad array of human cancers. Dr. Wahl was one of the first to develop radio-immunotherapy for the treatment of non-Hodgkin’s lymphoma. Dr. Wahl also pioneered computer methods that joined PET and CT technologies to form “fusion” images of cancer, and has been involved in the early stage evaluation of PET CT fusion technology,an increasingly routine procedure at Johns Hopkins.

Technology Portfolio

• C11439: Personalized Disease Tracking Imaging System • C11130: An Automatic Method for the Determination of Normal

Reference Values in PET, SPECT, CT, MRI and other Molecular Imaging Studies

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Clifford Weiss, M.D. Assistant Professor, Radiology-Vascular and Interventional Radiology Clinical Director, Johns Hopkins Center for Bioengineering, Innovation and Design

Research Interests Dr. Weiss’ research foci include development and implementation of new MRI-guided interventions, the development of new interventional radiology techniques for use with cellular therapeutics, and development of new devices for interventional radiology. He has extensive grant funding from various societies, foundations, and corporations.

Technology Portfolio • C11892: Accessory for Reduction of Biofilm on Catheters • C11589: Implantable Three-way Diaphragm Valve • C11434: Hemodialysis port for increased longevity and efficacy of access

licensing Associate Heather Bakalyar Portfolio Director Phone: 410-516-6653 Email: hbakaly1@jhmi.edu

sites

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inventor Fact Sheets


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Images of Vogelstein, Kinde, and the Neurology Department were taken by Keith Weller Commercial Photography for Johns Hopkins Medicine.

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