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Arkansas Sickle Cell Support Services

The Voice of Sickle Cell

Volume I, Issue II

Arkansas Sickle Cell Support Services

May 2010

Help For Sickle Cell Anemia Inside this issue: If you are suffering from sickle cell anemia, what you’re about to read in If you arecould suffering from sickle cell anemia,relief whatfrom you’re about to read this report be the beginning of blessed debilitating pain.in this report could be the beginning of blessed relief from debilitating pain. Consider this startling statistic: Sickle cell disease is the most Considerinherited this startling statistic: Sickle cellUnited disease is the affecting most common blood disorder in the States, common inherited blood disorder in the United States, affecting 70,000 to 80,000 Americans. The disease is estimated to occur in 1 in 70,000 to 80,000 Americans. The disease is estimated to occur 500 African Americans and 1 in 1,000 to 1,400 Hispanic Americans. in 1 in 500 African Americans and 1 in 1,000 to 1,400 Hispanic Americans. It affects millions of people worldwide. Sickle cell anemia is most common It affects millions ofancestors people worldwide. Sickle cellMediterranean anemia is most common among people whose come from Africa; countries among people Turkey, whose ancestors from Africa; Mediterranean countries such as Greece, and Italy;come the Arabian Peninsula; India; and such as Greece, regions Turkey, in and Italy; the Arabian Peninsula; and of Spanish-speaking South America, Central America,India; and parts Spanish-speaking regions in South America, Central America, and parts of the Caribbean. the Caribbean. In this report you’ll learn the underlying cause of sickle cell In this and report you’ll the of sickle anemia, what youlearn can do tounderlying control thecause recurrence of cell painful anemia, what you can do remain to control the recurrence of painful sickle cell and crises - and possibly symptom free. sickle cell crises - and possibly remain symptom free. Let’s start with what is actually going on inside the body of someone with Let’s start with what is actually going on inside the body of someone with this disease. this disease.

Finally, Researchers Have Found A Way to Relieve the Pain

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So What Causes Sickle Cell Pain?

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Sickle Cell Anemia Symptom Relief

3

Hemoxide Ramps Up Your Circulation

4

Rejuvin, the Water of Life

4

Understanding Sickle Cell Anemia

Sickle cell disease is a group of disorders that affects hemoglobin, the molecule in red blood cells that delivers oxygen to cells throughout the body. People with Special points of interest: this disorder have atypical hemoglobin molecules called hemoglobin S, which can change the shape of normal red blood cells into a sickle, or crescent, shape. • Sickle Cell disease is the most common inherited Signs and symptoms of sickle cell disease usually begin in early childhood. blood disorder in the Characteristics of this disorder include a low number of red blood cells United States, affecting (anemia), repeated infections, and recurring episodes of pain. 70,000 to 80,000 Americans. The severity of symptoms varies from person to person. Some people have mild symptoms, while others are frequently hospitalized for more serious complications.

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• Inadequate amounts of nitric oxide is directly correlated with the severity of the pain


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Inadequate amounts of nitric oxide is directly correlated with the severity of pain.

The signs and symptoms of sickle cell disease are caused by the sickling of red blood cells. When red blood cells sickle, they break down prematurely, which can lead to anemia. Anemia can cause shortness of breath, fatigue, and delayed growth and development in children.

The rapid breakdown of red blood cells may also cause yellowing of the eyes and skin, which are signs of jaundice. Painful episodes can occur when sickled red blood cells, which are stiff and inflexible, get stuck in small blood vessels. These episodes deprive tissues and organs of oxygen-rich blood and can lead to organ damage, especially in the lungs, kidneys, spleen, and brain. A particularly serious complication of sickle cell disease is high blood pressure in the blood vessels that supply the lungs (pulmonary hypertension).

Pulmonary hypertension occurs in about onethird of adults with sickle cell disease and can lead to heart failure.

Finally, Researchers Have Found A Way To Relieve The Pain Associated With Sickle Cell Disease Researchers at Duke University and Howard Hughes Medical Institute discovered one of the keys to the cause of pain in Sickle Cell Anemia, also known as Mediterranean Blood Disease. Their findings were reported in the Proceedings of the National Academy of Sciences, Jan. 31, 2005. Here’s what they found. Picture red blood cells floating in blood in the arteries of someone who does not have sickle cell anemia. Their blood pulses with each beat of the heart. As the pulse of blood moves through the arteries, they expand to allow the blood to pass. This happens because the red blood cells produce and release a signaling molecule to tell

arterial walls to expand. The signaling molecule they make is Nitric Oxide. Now picture the red blood cells of someone with sickle cell anemia. Many of them are distorted into a sickle shape, so big that some get stuck going down small capillaries. But even worse, when the blood pulses, researchers at Duke discovered that the walls of the arteries don’t expand. Since they don’t expand circulation is restricted and oxygen starvation occurs in tissues downstream, causing the pain and other symptoms of sickle cell anemia.

In normal blood, when red cells enter a narrow passage, they sense pressure on their membranes, and respond by releasing nitric oxide. This nitric oxide causes the smooth muscle in the blood vessel wall to relax. This opens up the vessel to allow the cells to pass through.


Volume I, Issue II

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So What Causes Sickle Cell Pain? In sickle cell anemia patients, the red blood cells can’t open up blood vessels as they should. The reason is because there isn’t enough nitric oxide present in the cells to do the job. Inadequate amounts of nitric oxide is directly correlated with the severity of pain. The Duke/HHMI researchers were able to confirm this with their studies.

The less nitric oxide your blood cells can produce, the greater the pain. And to make matters worse, with severe sickle cell, when oxygen levels start to drop, blood vessels naturally constrict or get smaller. This just complicates the problem even more. So what does all this mean?

The Duke/HHMI researchers concluded that this abnormal nitric oxide processing might be the real cause of restrictions in the circulatory system of sickle cell patients. And when it comes to the severity of sickle cell symptoms, the sickle shape of the red blood cells may be less important than oxygen depletion.

Sickle Cell Anemia Symptom Relief The Duke/HHMI study, and

In concluding their report,

Nitric oxide in gaseous

several other studies too,

the researchers essentially

form can be delivered

found that administering

said if there was a way to effectively increase nitric oxide

through breathing it in

nitric oxide to people with sickle cell anemia does relieve symptoms. Reports show replenishing the deficient nitric oxide can re verse red cell sickling. This helps restore some of the diminished gas-exchange capacity of sickle cell anemia hemoglobin. Less sickling would also relieve anemia because fewer red cells would be lost to hemolysis (bursting.)

production in the body, people suffering from sickle cell anemia would finally be able to do something to relieve and eliminate their painful symptoms. However, the researchers didn’t know of an effective way to do this. They speculated sometime in the future a way to produce adequate amounts of nitric oxide might be developed.

through the lungs. But the effects are limited because nitric oxide is highly reactive so concentrations are kept low or it would cause damage. In addition, nitric oxide only lasts a few seconds when breathed. At low concentrations, nitric oxide is quickly absorbed and used up in the lungs, rather than penetrating deeply into the body’s tissues. So it is of no help.


Arkansas Sickle Cell Support Services What the researchers didn’t know:

Germaine Johnson Founder and President Arkansas Sickle Cell Support Services P. O. Box 4186

Researchers have said there were no drugs that would increase the amount of nitric oxide. What they didn’t know was that a little known, safe and natural product had been developed a decade ago that effectively produces nitric oxide in your body. It’s called hemoxide.

Little Rock, AR 72214

Hemoxide Ramps Up Your Circulation

Phone: 501– 590-6943 Fax:

Hemoxide contains two important types of nutrients. One type supplies the molecular building blocks needed to produce nitric oxide in the body. The other group stimulates nitric oxide production. That way your body can produce higher amounts of nitric oxide through its own natural processes.

arsicklecell@yahoo.com

Health-Reports.com http://sicklecellcurefoundation.org/200 9/11/sccf-takes-on-sickle-cell-diseasescd/

This effect has not been achieved with drugs or any other nutritional supplements. Hemoxide and its sister products are classed as medical foods, so they can be doctor-prescribed or purchased without a prescription. Hemoxide contains two important types of nutrients. One type supplies the molecular building blocks needed to produce nitric oxide in the body. The other group stimulates nitric oxide production. That way your body can produce higher amounts of nitric oxide through its own natural processes.

Jaelyn Epps Gold Award Project St. Mark Girl Scout Troop 6659

This effect has not been achieved with drugs or any other nutritional supplements. Hemoxide and its sister products are classed as medical

Rejuvin, The Water Of Life An enhanced water which can rejuvenate your cells at the most elemental level. It is a top product for every autoimmune disease, Alzheimer's, arthritis, diabetes, osteoporosis, cancer and more - and is an amazing anti-aging product. This is a brand new product that works great for sickle cell anemia. Though nothing can reverse the genetic malfunction in sickle cell anemia, Rejuvin can rejuvenate and refresh your blood cells so the sickle cells work more efficiently.


Sickle Cell Newsletter - May 2010  

It affects millions of people worldwide. Sickle cell anemia is most common among people whose ancestors come from Africa; Mediterranean coun...

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