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Cancer Systems Biology Neurosciences Ageing and Age-related diseases Pharmacoepidemiology

Institute for Biomedical Research in Lleida Rovira Roure, 80 28198 Lleida · Catalunya · Spain Ph: +34 973 702 201 www.irblleida.org @Info_IRBLleida Director: Prof. Dr. Xavier Matias-Guiu

IRBLleida 2013 Researchers Research Groups Granted Public Projects Ongoing R&D Projects Scientific Production Global Impact Factor New Clinical Trials Budget

Patents Pipeline 380 31 15 50 311 1.071 82 3.560.000 €

CANCER US 14/099,266 EP 14155510.2

Diagnosing Subsets of Triple-Negative Breast Cancer Method to predict risk of recurrence in endometrial carcinoma

PHARMACOLOGY 2006004152

New 7-substituted indirubin-3’-oximes and their applications

NATURAL FUNCTIONAL INGREDIENTS ES2402643

Anticholesterolemic fiber combination

Strategic Research Projects GENOMIC APPROACH FOR INDIVIDUALIZING ENDOMETRIAL CANCER DIAGNOSIS, PROGNOSIS AND TREATMENT

NEFRONA - NATIONAL OBSERVATORY ON ATHEROSCLEROSIS IN NEPHROLOGY The NEFRONA project is a pioneering initiative to promote research in vascular disease in patients with chronic kidney disease (CKD) distributed throughout the Spanish territory study.

The project is focused on whole exome sequencing study of metastatic endometrial cancer (EC), as well as of alterations involved in radiation-resistance, and invasion/metastasis profiling. The aim is: R&D Field(s): Endometrial Cancer Budget: 400.000 € IP: Dr. Xavier Matias-Guiu

To identify specific molecular alterations of metastatic EC for improving diagnosis. To test pharmacological inhibitors as potential treatments for patients with metastatic EC.

PREDICTUS - USE OF SYSTEM BIOLOGY TO PREDICT AND DIAGNOSE TRANSITORY ISCHEMIA AND ISCHEMIC TOLERANCE

R&D Field(s): Vascular Pathology Chronic Kidney Disease Budget: 700.000 € IP: Dr. Elvira Fernández

HUMAN FUNGAL PATHOGENS UNDER OXIDATIVE STRESS: ADAPTATIVE MECHANISMS AGAINST HYPOXIA AND REACTIVE-OXIGEN SPECIES

PREDICTUS is a multidisciplinary and translational project to assess new biomarkers to stroke recurrence, to diagnosis of brain ischemia and ischemic tolerance in humans. R&D Field(s): Stroke, Transient ischemic attacks, Brain ischemia Budget: 300.000 € IPs: Dr. Francesc Purroy, Dr. Joaquim Egea

To identify transient ischemic attacks (TIA) human biomarkers, through metabolomic and lipidomic profiling, To determine stroke tolerance in human patients using neuroimaging and neurological evaluations.

To study the atherosclerotic burden of CKD in ≈3000 patients at different stages CKD To evaluate the usefulness of imaging techniques and emerging biomarkers in predicting cardiovascular risk. www.nefrona.es

Invasive pathogens frequently interact with the human host in niches low in oxigen, often associated with increased level of reactive oxygen species and carbon dioxide.

R&D Field(s): Microbiology, Human Pathogens Budget: 330.000 € IP: Dr. Enric Herrero

Pathogenomics project is focused on the determination of the molecular mechanisms involved in fungal responses and host interactions under oxygen stress in vitro (hypoxia and normoxia). The main aim is to set pathogens’s sensitivity to distinct oxigen niches for further development of therapeutic strategies against invasive fungal diseases.

Spin-offs and Innovation models Dietary Molecular Diagnostics, SL DMD, SL. offers accurate therapeutic solutions based on personal nutritional recommendations to healthcare professionals. These recommendations are based on merged results on individual’s molecular data:  Genetics: the risk of suffering certain diseases  Nutrigenomics : the impact of food in gene expression  Biochemistry: common molecular biomarkers  Metabolomics: the effect of food and exercise on metabolism

Advanced Biomedical Research Center CREBA is the result of a joint-venture between IRBLleida, a multinational and local company and the Council of Lleida to boost a strategic swine research center in the region of Lleida. It is expected that the facilities will promote new science-related activities such as specialized training in new surgical techniques as well as biomedical research projects using swine as preclinical model. This new building (1.200 sqm) will be fully equipped.

Detection and Treatment of Atherothrombotic Diseases UDETMA is a pioneering organization within the Nephrology Service in Hospital Universitari Arnau de Vilanova de Lleida devoted to the study and the prevention of cardiovascular disease (CD). UDETMA uses sensitive diagnostic tools to perform non-invasive tests to predict risk from suffering CD and offers hand-on training. www.udetma.com

Surgery rooms Pre-surgery room Training room Sterilization room Physiology studies room Multifunctional room Laboratory Storage rooms Wardrobe rooms Offices Swine facilities

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Contact us: www.irblleida.cat info@irblleida.cat


Institute for Biomedical Research in Lleida