2. Butyric Acid and Propionic Acid as alternatives for a better intestinal health Leeson et al. (2005) have researched into the subsequent weight gain after birds having been challenged with a mixed oocyst culture. In this study, effected with broilers vaccinated at 21 days, the additional benefit of butyric acid on growth rate 7 days after the challenge (P<0,05) was confirmed, showing evidence that broilers previously fed a butyrate-supplemented feed are better prepared to overcome the stress caused by a coccibreak. There are stills signs indicating that the preventive use of butyric acid curbs the devastating effect of a coccibreak even going as far as allowing for a quick recovery after meeting that challenge.
On another research study Van Immerseel at al. (2003) worked on the influence of short chain fatty acids on growth rate, virulence and invasion of gut epithelium by Salmonella typhimurium. The low gene expression by S. thyphimurium, when challenged by butyrate (butyric acid) or propionate (propionic acid), reduced the GIT invasion and colonization rate. Van Immerseel at al. have also shown the significant reduction of the colonization by S. enteritidis in the caecum, liver and spleen (P<0,05) of laying hens.
20 18 16 14 12 10 8 6 4 2 0
<102 CFU/g 102-105 CFU/g >105 CFU/g
Butyrate acid Propionic acid
Effect on dietary Sodium Butyrate on caecal Salmonella colonization in broilers at day 8 (Van Immerseel et al., 2004)
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Novyrate – Optimal solution that supports Gut Integrity