The problems with liquid butyric acid regarding to the odour and volatility can also be overcome by encapsulation the product. An other advantage of this method is that with the correct type of encapsulation it could pass the stomach as such and subsequent release the active substance in the small intestine. Also a combination of butyric acid with glycerol is a form of protection, as the glycerol-acid compound is not influenced by the pH of the stomach, and allows slow release of the undissociated fatty acid in the various parts of the intestinal tract.
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Tributyrin is a precursor of butyrate. Tributyrin contains three butyric acid moieties esterified to glycerol. When completely hydrolyzed by cellular lipases or esterases, it yields 3-fold more butyric acid than sodium butyrate. Tributyrin has a plasma half-life of 40 minutes, compared to 6 minutes using butyrate. To evaluate all the literature of butyrate, also the human related literature is reviewed and included in this study.
Novyrate – Optimal solution that supports Gut Integrity