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Novyrate®­­: Mode of Action 7. Butyrate limits the invasiveness of salmonella reducing its colonization Butyrate inhibit pathogens, such as Salmonella, E.Coli via its anti-bacterial mode-of-action. Byrate also ‘downregulate’ the pathogenity gene of Salmonella, thereby decreasing the invasion of this harmful bacteria. 20 18 16 14 12 10 8 6 4 2 0

<102 CFU/g 102-105 CFU/g >105 CFU/g

Control

Acetic acid

Butyrate acid Propionic acid

Effect on dietary Sodium Butyrate on caecal Salmonella colonization in broilers at day 8 (Van Immerseel et al., 2004)

It has been shown that addition of butyric acid to broiler feed can significantly reduce Salmonella colonization. Van Immerseel et al. (2004) found butyric acid 80more effective in decreasing cecal colonization of S. Enteritidis than 70 propionic and formic acids. Butyrate

was shown to affect the interaction of Salmonella enterica with the intestinal epithelium, characterized by a reduction of invasion. Gantois et al. (2006) showed that butyrate down-regulated the expression of a specific set of genes in Salmonella, thereby reducing the invasion on Salmonella in the intestine.

60

16

50 F u n c t i o n a l 40

N u t r i e n t s

F e e d

A d d i t i v e s

acetateF a r m lactate

P a c k s

Novyratenovbroen28102016ldef  

Novyrate – Optimal solution that supports Gut Integrity

Novyratenovbroen28102016ldef  

Novyrate – Optimal solution that supports Gut Integrity

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