3. Butyrate Enhances the Intestinal Barrier by Facilitating Tight Junction Assembly Butyrate promotes the development of the intestinal barrier by regulating the assembly of tight junctions as shown by the reorganization of tight junction proteins, as well as the development of TER. We conclude that butyrate enhances the intestinal barrier by regulating the assembly of tight junctions. Permeability of tight junctions is determined by measuring: Trans-epithelial electrical resistance (TEER) Butyrate upregulateâ€™ the expression of tight junction proteins, making the penetration of harmful bacteria through the epithelial layer difficult, and protecting the invasion of pathogenic bacteria in the bloodstream.
Inulin is a macromolecule indigestible in the small intestine. In the below study, it can be observed that there was less leakage of inuline in the butyrate group than in the control, thanks to the butyrate action on tightening the junctions in the epithelium.
In tissue culture and live rats, butyrate causes a large and rapid decrease in
permeability. This shows that butyrate plays an important role in the maintenance of gut barrier integrity. Impaired gut barrier integrity is associated with many diseases, including fatty liver, heart failure and auto immune diseases. 11
Novyrate – Optimal solution that supports Gut Integrity