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Novyrate

ÂŽ

Optimal solution that supports Gut Integrity


The Intestine Integrity Nowadays genetic potential of monogastric farm animals allows the animals to grow faster by using less feed. To perform up to this genetic potential the nutritional quality of the diets needs to meet the animal’s requirements. Proper & first phases feeding will have a significant impact on the intestinal bacterial community and the development of the intestinal structure, integrity and functionality. A sub-optimal intestinal functionality has a significant and negative impact on the animal performance up till the end of the growing period.

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In the small intestine a major part of digestion and almost all absorption of nutrients takes place. Time duration of feed substrate in the small intestine is relatively short. This requires a healthy intestinal status for optimal and undisturbed nutrient utilization and growth. In today’s modern production, stress caused by systemic changes in the animal lead to loss of gut barrier integrity.

This affected intestinal integrity can result in various problems, such as: Reduced digestive capacity, Less absorption-surface for nutrients, Dysbacteriosis (microbial imbalance), Loss of intestinal barrier function (bacterial invasion; infection; inflammation; allergic reactions, harmful substances that cause damage to organs) Poor growth & low feed efficiency Economical losses

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The Intestine Integrity The role and importance of tight junctions The intestine allows the absorption of nutrients, while also functioning as a barrier, which prevents antigens and pathogenic bacteria to enter the mucosal tissue, and causing diseases. Increased intestinal permeability (= reduced barrier function) is implicated in autoimmune, inflammatory and atopic diseases.

Chronic inflammatory diseases are characterized by a leaky intestinal barrier. Entry of unwanted antigens can lead to ‘systematic inflammatory response syndrome’, characterized by a whole body inflammatory state, and multiple organ failure.

The space between epithelial cells is ‘sealed’ by tight junction proteins, a multi-functional complex which regulates the permeability of the intestinal barrier. Tight junctions are composed of trans-membrane components (proteins) that mediate adhesion and form the paracellular diffusion barrier.

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The vicious circle of tight junctions barrier disruption leads to inflammatory response putting the gut in a state of defense instead of a state of absorption. Leaky tight junctions with fluid from the host leaking into the lumen triggers inflammation that translates into performance losses, wet litter situation in poultry, bacterial enteritis and diarrhea.

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Novyrate

®

Mode of Action

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Stimulating growth of villi

p. 8 - 9

Balancing micro-flora with selective control on pathogens and micro- organisms

p. 10

Butyrate enhances the Intestinal barrier by facilitating tight junction assembly

p. 11

Butyrate protects intestinal cells from bacterial invasion and translocation

p. 12

p. 14

Butyrate acts as signaling molecule

Butyrate has a potent anti inflammatory effect and affect positively the immune system

p. 15

Butyrate limits the invasiveness of salmonella reducing its colonization

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NovyrateŽ­­: Mode of Action Butyrate has mainly been used as a direct energy source. Research has now produced evidence that specific metabolic effects can be attributed to butyrate making it an important and useful metabolic molecule in animal feeding.

1. Stimulating growth of villi.

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Butyrate has been shown to have positive effects on intestinal development and function. It is reported that butyrate will increase villi height, crypt depth, plica area and mucosa thickness in the small intestine, mainly in the jejunum and proximal ileum. This will increase absorptive capacity of the small intestine and as a result improve performance. It enhances enterocytes and intestinal villosity development. Butyrate helps support the development of epithelial cells by providing a readily available source of energy. Further, supplementation of butyrate in milk replacer or starter diet positively affects stomach and small intestinal development in newborn piglets, veal calves and broiler chicken. A balanced intestinal micro-flora is an important factor contributing to intestinal health and consistent animal performance.

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NovyrateŽ­­: Mode of Action 2. Balancing micro-flora with selective control on pathogens and micro-organisms

Butyrate stimulate the proliferation of the beneficial bacteria, inhibiting the development of pathogenic bacteria leading to a better balanced microflora. Literature data indicate that butyric acid has antimicrobial properties. Adding butyrate to piglet diets increased the lactobacilli:enterobacteria ratio in the caecum due to an increase in lactobacilli numbers. Further, supplementation of butyrate in milk replacer or starter diet positively affects stomach and small intestinal development in newborn piglets, veal calves and broiler chicken.

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3. Butyrate Enhances the Intestinal Barrier by Facilitating Tight Junction Assembly Butyrate promotes the development of the intestinal barrier by regulating the assembly of tight junctions as shown by the reorganization of tight junction proteins, as well as the development of TER. We conclude that butyrate enhances the intestinal barrier by regulating the assembly of tight junctions. Permeability of tight junctions is determined by measuring: Trans-epithelial electrical resistance (TEER) Butyrate upregulate’ the expression of tight junction proteins, making the penetration of harmful bacteria through the epithelial layer difficult, and protecting the invasion of pathogenic bacteria in the bloodstream.

Inulin is a macromolecule indigestible in the small intestine. In the below study, it can be observed that there was less leakage of inuline in the butyrate group than in the control, thanks to the butyrate action on tightening the junctions in the epithelium.

In tissue culture and live rats, butyrate causes a large and rapid decrease in

permeability. This shows that butyrate plays an important role in the maintenance of gut barrier integrity. Impaired gut barrier integrity is associated with many diseases, including fatty liver, heart failure and auto immune diseases. 11


Novyrate®­­: Mode of Action 4. Butyrate protects intestinal cells from bacterial invasion and translocation Campylobacter infection, is currently one of the leading causes of foodborne bacterial gastroenteritis, is associated with bacterial invasion in, and translocation through the intestinal epithelium, and disruption of tight junctions.

Butyrate’s protective role during Campylobacter jejuni infection leads to Decreasing bacterial invasion into intestinal cells Improving tight junction integrity and intestinal health

The percentage of invaded Campylobacter jejuni bacteria in intestinal cells pre-treated with Butyrate for 24 and 48 hours, compared with untreated Control (100%)

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The percentage of invaded Campylobacter jejuni bacteria in intestinal cells pre-treated with Butyrate for 24 and 48 hours, compared with untreated Control (100%)

Butyrate also reduces the paracellular translocation of Campylobacter. 24 hours after bacterial inoculation, approx. 20x less bacteria were recovered:

Number of translocated Campylobacter jejuni (cfu/ml)

1.4 x 10â ľ for Butyrate-treated intestinal cell lining 3.0 x 10â ś for non-treated intestinal cell lining Improving tight junction integrity and intestinal health

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Novyrate®­­: Mode of Action 5. Butyrate acts as signaling molecule. Enteroendocrine cells represent a direct signaling pathway from gut microbes to host metabolism, controlling energy intake and expenditure. Eneteroendocrine cells respond to nutrient intake by secreting hormones.

Also gut microbes have been shown to stimulate gut hormones, probably by the products of bacterial fermentation, the SCFAs. So, the SCFAs function both as energy source and as signaling molecule.

Signal Transduction

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6. Butyrate has a potent anti-inflammatory effect and affect positively the immune system Inflammation of the intestinal tract is the result of an overactive immune response that is linked to an imbalance of the normal types of bacteria found in the intestines.

Butyrate has been known to modulate immune response and to have a beneficial effect in the colon. A shortage of butyrate can result in intestinal inflammation.

Butyrate has well-known and wellstudied anti-inflammatory effects and is able to strengthen the intestinal mucosal barrier, making it an ideal preventive and therapeutic agent against intestinal inflammation

Enteric coated butyrate was reported to reduce mucosal inflammation in ileum and cacum in patients suffering from Crohn disease (Di Sabatino, 2005). Sodium butyrate directly decreases production of inflammatory cytokines by macrophages in response to E. Coli lipopolysaccharide.

Effect of Butyrate on TNF-Îą and IL-6 in serum of weaning piglets

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Novyrate®­­: Mode of Action 7. Butyrate limits the invasiveness of salmonella reducing its colonization Butyrate inhibit pathogens, such as Salmonella, E.Coli via its anti-bacterial mode-of-action. Byrate also ‘downregulate’ the pathogenity gene of Salmonella, thereby decreasing the invasion of this harmful bacteria. 20 18 16 14 12 10 8 6 4 2 0

<102 CFU/g 102-105 CFU/g >105 CFU/g

Control

Acetic acid

Butyrate acid Propionic acid

Effect on dietary Sodium Butyrate on caecal Salmonella colonization in broilers at day 8 (Van Immerseel et al., 2004)

It has been shown that addition of butyric acid to broiler feed can significantly reduce Salmonella colonization. Van Immerseel et al. (2004) found butyric acid 80more effective in decreasing cecal colonization of S. Enteritidis than 70 propionic and formic acids. Butyrate

was shown to affect the interaction of Salmonella enterica with the intestinal epithelium, characterized by a reduction of invasion. Gantois et al. (2006) showed that butyrate down-regulated the expression of a specific set of genes in Salmonella, thereby reducing the invasion on Salmonella in the intestine.

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Key benefits of using butyric acid source

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Key benefits of using butyric acid source Help support the development of epithelial cells by providing a readily available source of energy Enhance enterocytes a intestinal villosity development by stimulating villi growth Anti Microbial Control. Stimulate the ability of the animal to overcome bacterial infections Effect on the Microbiota pattern & balance Positively affecting the immune system Increased nutrient digestibility Stimulation of digestive enzyme secretions Modification of the lumen microbiota Enhancing epithelial integrity

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Technical Bulletins

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1. A review of Butyrate in Animal nutrition 2. Butyric Acid and Propionic Acid as alternatives for a better intestinal health

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Technical Bulletin

1. Butyric acid in animal nutrition

Abstract Organic acids like butyric acid are used for many applications in human and animal nutrition. The use for the preservation of foodstuffs or single components is accepted all over the world as a very effective method to control growth of bacteria (E.coli, Salmonella), mold and yeast. There is ample evidence that organic acids can improve performance of piglets and to a lower extent also those of growing pigs and chicks. In contrast to other organic acids, butyric acid seems also be effective as nutrient of the intestinal mucosa. In this role it acts as a stimulator of the intestinal trophism in terms of renewal of basal cells, increasing density and length of villi, and also various other factors related to gut integrity. Through these effects butyrate can modulate the intestinal flora. The aim of this review is to evaluate the literature data about the effect of butyric acid in monogastric animals. Special attention is given to its effect on gut integrity in these animals.

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Butyric acid is widely distributed in nature as normal constituent in milk of sows, cows and other species. In addition, it is produced in the intestine subsequent to digestive metabolic degradation of fibers and carbohydrates. Bacteria which produce butyric acid mainly include sugar fermenters such as Clostridium spp., Eubacterium spp., Fusobacterium spp., Butyrivibrio spp. The pKa value of butyric acid is 4.82 and comparable with that of acetic and propionic acids. The NE value for pigs is 17.65 MJ/kg and the ME value for poultry 22.45 MJ/kg. Butyric acid is available in the liquid form, but also as Na and Ca salts. In practice, there are limits of the use in liquid form, since it is has as an unpleasant odour and the volatility is very high. Thus, in practice, mainly the salts of butyric acid are used, since they are more stable and less odorous. In an aqueous solution sodium butyrate easily dissociates into butyric acid. The salt forms of butyric acid do not have the potency of reducing the pH of the environmental, because of the replacement in salts of the H+ by Na+ or Ca2+.

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The problems with liquid butyric acid regarding to the odour and volatility can also be overcome by encapsulation the product. An other advantage of this method is that with the correct type of encapsulation it could pass the stomach as such and subsequent release the active substance in the small intestine. Also a combination of butyric acid with glycerol is a form of protection, as the glycerol-acid compound is not influenced by the pH of the stomach, and allows slow release of the undissociated fatty acid in the various parts of the intestinal tract.

For full paper review (20 pages), please contact Innovad Technical team at info@innovad-global.com

Tributyrin is a precursor of butyrate. Tributyrin contains three butyric acid moieties esterified to glycerol. When completely hydrolyzed by cellular lipases or esterases, it yields 3-fold more butyric acid than sodium butyrate. Tributyrin has a plasma half-life of 40 minutes, compared to 6 minutes using butyrate. To evaluate all the literature of butyrate, also the human related literature is reviewed and included in this study.

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Technical Bulletin

2. Butyric Acid and Propionic Acid as alternatives for a better intestinal health

Poultry farming globalization gave occasion to important changes in broiler production. Consumer trends, striving for the need to have access to safer food with fewer risks to the human health, demand the gradual withdrawal of antibiotics, which increases the flocks’ exposure to infectious agents. Evaluating potential alternatives to antibiotics is therefore badly needed in order to try and find effective options able to stabilize the normal intestinal flora, reduce bacterial infection challenges in the digestive tract and improve the vitality of enterocites and villi.

According to Pryde et al. Butyrate (butyric acid), which is a by-product of microbial fermentation, is important to the normal development of epithelial cells, entailing a better vitality of enterocites and villi. Paul van der Wielen et al. (2000) state the possibility to realize that in early stages of broilers’ life Enterobacteriaceae, Enterococci and Lactobacilli form the most important bacterial group in the caecum. Bacteroides spp and Eubacterium spp appear and stabilize after the second week of life. It is important however to point out that, right from the first day, anaerobic bacteria (primarily Clostridium spp) concentrate in large scale in birds’ caecum. This statement is of particular interest as during broilers’ life cycle these bacteria remain in higher quantity in the caecum, even after the natural decline of aerobes.

Amid the various alternatives available today, organic acids are worth being considered. Organic acids still act in different ways, depending on their concentration, chemical structure, whether they are present in pure form, acid or salt, associated (various acids mixed), encapsulated or not, making their use more or less efficient if they are not included in the feed in the right way. 24

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<102 CFU/g aerobes may still open the door to Salmonella spp CFU/g and Escherichia102-105 coli contamination. >105 CFU/g Volatile fatty acids show up as from the first day of birds’ life and one of their main functions is to keep a balance among the naturally resident species in the Gastro-Intestinal Tract (GIT).

Control

Acetic acid

Van der Wielen et al (2000) have shown a correlation between un-dissociated butyrate, propionate and the control of pathogens in the Butyrate acid caecum of acid youngPropionic birds.

the natural production of butyric and propionic Effect on dietary Sodium Butyrate onAs caecal Salmonella colonization Moments of disbacteriosis – when a diet in broilers at day 8 (Van Immerseel et al., 2004) acid in the distal region of the GIT and caecum substrate, a contaminated environment or of young birds is too low and increases only until inadequate handling harms aerobes – propitiate the 15th day of life (van der Wielen et al., 2000) an unrestrained growth of aerobes giving rise to it is of the utmost importance to include in the a retro-contamination that may originate various feed formulation a reliable feed additive in the first enteritis including necrotic enteritis. stages of broilers’ life. The predominance of one or another species of 80 70 60 50 40 30 20

acetate lactate proprionate butyrate

10 0 -10

Ceacal VFA concentrations in broilers (in _mol/g content). Butyrate production in the caeca starts after 12-14 days of age.

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Technical Bulletin

2. Butyric Acid and Propionic Acid as alternatives for a better intestinal health Leeson et al. (2005) have researched into the subsequent weight gain after birds having been challenged with a mixed oocyst culture. In this study, effected with broilers vaccinated at 21 days, the additional benefit of butyric acid on growth rate 7 days after the challenge (P<0,05) was confirmed, showing evidence that broilers previously fed a butyrate-supplemented feed are better prepared to overcome the stress caused by a coccibreak. There are stills signs indicating that the preventive use of butyric acid curbs the devastating effect of a coccibreak even going as far as allowing for a quick recovery after meeting that challenge.

On another research study Van Immerseel at al. (2003) worked on the influence of short chain fatty acids on growth rate, virulence and invasion of gut epithelium by Salmonella typhimurium. The low gene expression by S. thyphimurium, when challenged by butyrate (butyric acid) or propionate (propionic acid), reduced the GIT invasion and colonization rate. Van Immerseel at al. have also shown the significant reduction of the colonization by S. enteritidis in the caecum, liver and spleen (P<0,05) of laying hens.

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Control

Acetic acid

Butyrate acid Propionic acid

Effect on dietary Sodium Butyrate on caecal Salmonella colonization in broilers at day 8 (Van Immerseel et al., 2004)

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In this same study, when evaluating the colonization and horizontal contamination by S. enteritidis in the presence of encapsulated sodium butyrate, the researchers realized that, out of the birds orally inoculated with S. enteritidis on day 5, 36% of the control birds were still contaminated at slaughtering, while 4.6% only, out of the group fed sodium butyrate, were contaminated. Research work carried out so far permit to consider that sodium butyrate, alone or combined with propionic acid, provides a promising alternative to antibiotics as growth promoters or even an advanced option combining both â&#x20AC;&#x201C; antibiotics and butyrate â&#x20AC;&#x201C; as a synergic option to potentiate their benefits and ensure the best possible intestinal health leading to optimal production results and safety in the food chain. There is a consensual thinking that the effect of these acids, once included in compound feed, will strongly depend on their ability to reach the distal parts of the gastro intestinal tract.

The micro encapsulation technology to protect mid chain fatty acid activity is a safe way to meet that challenge. INNOVAD Technical Team Article written in Portuguese by L. Galeazzi March 2011

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Product Description

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Novyrate® EB Gut-Active (Esterified butyrin)

Novyrate® C Gradual Release (32% coated Sodium butyrate)

Novyrate® FP Protected (70% protected Sodium butyrate)

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NovyrateÂŽ EB

GUT-ACTIVE (Esterified butyrin)

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Product Description Product Data Sheet

NOVYRATE® Esterified Butyrins EB The increasing animal genetic potential puts a significant stress on the animals’ digestive Scope Esterified butyrins are combined molecules Key features andandbenefits of Mono-esters system, often leading to a suboptimal digestive process nutrient absorption. The negative impact of sub-optimal feed utilization has a significant impact on the economical viability of the composed out of a glycerol structure and butyrate and Di-Tri esters farm. Mono-butyrin is an important dietary component that can help balance and stimulate a molecules. The final result of the esterification healthy intestinal microflora. Different esters forms have different activity and is a combination of mono-, diand tributyrins Complementary feed. A synergetic combination of Esterified Butyrins, with immediate activity in Description the early part of the intestinal tract, and a prolonged towardspH the hindgut. benefits. Esters effect are NOT dependent (like organic which act as a source of butyrate molecules Esterified butyric acid, flavouracids). compounds, carrierisand anti-caking. There value in combining. in the intestinal tract. Based on the molecules Components Physical appearance origin, it isPhysical easy to&understand that these “fat-type” Technical : Free flowing powder. Mono-esters : white Di-Tri esters Colour structures Specifications can only be digested in the presence Odour : characterisitic • pH stable (+ passes the • pH stable ( + passes the of the digestive enzyme lipase. By definition, this pH (10%) : 5,8 - 6,8 stomach & crop) & crop) stomach guarantees full stomach bypass properties at the Specific gravity • Small molecule: 0,602 - 0,702 kg/l• Bigger molecule level of the stomach while being activated after (no bacterial uptake) (+ easy uptake :byMax bacteria Moisture (KF) 3,5 % pancreatic lipase has been added. • 2 or 3 side chains leading to internal Colour change or variation does not affect performance.

(hydrolysis by endogenous

hydrolysis and effective

lipase)0,25 - 1 kg/T, anti-bacterial activity) 0.75 - 2 kg/T, Pigs (+ 25 kg): 0,25 - 0,75 kg/T, Sows: 1-2 kg/T, Broilers: During theApplication esterification process, it is ofPiglets: utmost & Dosage Layers / Breeders: 0,5 - 0,75 kg/T, 0,5 only - 1 kg/T • High supply of butyrate (+) • 1 Turkeys: side chain (+ escape importance that the reaction is controlled carefully from Standard 25 kg export worthy bags in anendogenous outer carton onlipase) wooden fumigated pallets. Other net in order toPackaging guarantee the desired stability of (1kg*, the 5 kg*, 10 kg*, 25• kg*, weights 750-1000kg, on demand. *Unit packs are packed in Uptake in the bulk) bloodstream an outer carton up to max. 25 kg.(+ action within the whole product. A correct catalyst, the right esterification 2 years when stored in a cool, well ventilated and dry environment out of direct sunlight in metabolism) speed andShelf the Life final purification step need expertise unopened packing. • Relative low supply of and deep Item chemical knowledge, resulting in a high 10257 Reference butyrate concentrated, pure and clear product with a high • Water soluble The information in this data sheet is to the best of our knowledge true and accurate. All instructions, recommendations and suggestions are made under stability inreserve. timeSince andtheduring conditions ofpelleting use are beyondprocess, our control, the manufacturer disclaims all liability for loss or damage suffered from the use of these data, suggestions or recommendations. guaranteed without the typical smell of butyric NOVYRATE® EB is acid.

Free-flowing With NO smell Non-corrosive (no ADR) Heat stable NOVYRATE® EB combines butyrate supply (quantity) and strong antibacterial activities (quality)

Antibacterial power (in vitro)Acids vs. Mono-Esters

S. Typhimurium

E. Coli

Butyric acid

1:400

1:400

Mono-esterified butyrins

1:1600

1:800

MIC concentrations for Mono-butyrin (Innovad 2012)

INNOV AD NV/SA Postbaan 69 2910 Essen - Belgium

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Product Description Product Data Sheet

NOVYRATE® ® EB EB Novyrate

Gut-Active (Esterified butyrin) Scope

The increasing animal genetic potential puts a significant stress on the animals’ digestive system, often leading to a suboptimal digestive process and nutrient absorption. The negative impact of sub-optimal feed utilization has a significant impact on the economical viability of the farm. Mono-butyrin is an important dietary component that can help balance and stimulate a healthy intestinal microflora.

Synergetic combination of Esterified Butyrins, with immédiate activity in the early part of the intestinal tract, and Complementary a prolonged effectcombination towards the Butyrins, hindgut. feed. A synergetic of Esterified with immediate activity in Description the early part of the intestinal tract, and a prolonged effect towards the hindgut.

Components

Esterified butyric acid, flavour compounds, carrier and anti-caking.

Physical & Technical

Physical appearance

: Free flowing powder.

Specifications

Colour

: white

Odour

: characterisitic

Application & dose

: 5,8 - 6,8 Pigs Specific gravity : 0,602 - 0,702 kg/l Piglet Weaner (5-12 kg b.w.) Moisture (KF) % – 2,0 kg/T : Max 3,51,0 Colour change or variation does not affect performance.0,75 – 1,0 kg/T Piglet (Pre)-starter (12 -25 kg b.w.) Sows (Barth care)& Dosage 1,5kg/T, – 2,0 kg/T Piglets: 0.75 - 2 kg/T, Pigs (+ 25 kg): 0,25 - 0,75 kg/T, Sows: 1-2 Broilers: 0,25 - 1 kg/T, Application Layers / Breeders: 0,5 - 0,75 kg/T, Turkeys: 0,5 - 1 kg/T Sows (lactation) 1,0 – 1,5 kg/T Standard 25 kg export worthy bags in an outer carton on wooden fumigated pallets. Other net Packaging weights (1kg*, 5 kg*, 10 kg*, 25 kg*, 750-1000kg, bulk) on demand. *Unit packs are packed in Pig Grower I (25-35 kg b.w.) 0,5 – 0,75 kg/T an outer carton up to max. 25 kg. Pig Grower (35 – 55 kg b.w.) 2 years when stored in a cool, well ventilated and dry environment 0,35out– of0,5 kg/T direct sunlight in ShelfII Life unopened packing. Pig Finisher (55-110 kg b.w.) 0,25 kg/T 10257 Item Reference pH (10%)

The information in this data sheet is to the best of our knowledge true and accurate. All instructions, recommendations and suggestions are made under

Poultryreserve. Since the conditions of use are beyond our control, the manufacturer disclaims all liability for loss or damage suffered from the use of these data, suggestions or recommendations. Broiler starter 0,75 – 1,0 kg/T Broiler Grover 0,500 kg/T Broiler finisher 0,250 kg/T Layer 0,5 kg/T Breeder 0,5 – 0,75 kg/T Turkey (0-6/8 w) 1,0 kg/T Calf Calf starer feed

1,0 kg/T

INNOV AD NV/SA Postbaan 69 2910 Essen - Belgium

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Product Data Sheet

NOVYRATE® EB Scope

The increasing animal genetic potential puts a significant stress on the animals’ digestive system, often leading to a suboptimal digestive process and nutrient absorption. The negative impact of sub-optimal feed utilization has a significant impact on the economical viability of the farm. Mono-butyrin is an important dietary component that can help balance and stimulate a healthy intestinal microflora.

Description

Complementary feed. A synergetic combination of Esterified Butyrins, with immediate activity in the early part of the intestinal tract, and a prolonged effect towards the hindgut.

Components

Esterified butyric acid, flavour compounds, carrier and anti-caking.

Physical & Technical

Physical appearance

: Free flowing powder.

Specifications

Colour

: white

Odour

: characterisitic

pH (10%)

: 5,8 - 6,8

Specific gravity

: 0,602 - 0,702 kg/l

Moisture (KF)

: Max 3,5 %

Colour change or variation does not affect performance.

Application & Dosage

Piglets: 0.75 - 2 kg/T, Pigs (+ 25 kg): 0,25 - 0,75 kg/T, Sows: 1-2 kg/T, Broilers: 0,25 - 1 kg/T, Layers / Breeders: 0,5 - 0,75 kg/T, Turkeys: 0,5 - 1 kg/T

Packaging

Standard 25 kg export worthy bags in an outer carton on wooden fumigated pallets. Other net weights (1kg*, 5 kg*, 10 kg*, 25 kg*, 750-1000kg, bulk) on demand. *Unit packs are packed in an outer carton up to max. 25 kg.

Shelf Life

2 years when stored in a cool, well ventilated and dry environment out of direct sunlight in unopened packing.

Item Reference

10257

The information in this data sheet is to the best of our knowledge true and accurate. All instructions, recommendations and suggestions are made under reserve. Since the conditions of use are beyond our control, the manufacturer disclaims all liability for loss or damage suffered from the use of these data, suggestions or recommendations.

INNOV AD NV/SA Postbaan 69 2910 Essen - Belgium

info@innovadglobal.com www.innovadglobal.com

PDS/1 DATED 20-07-2012 NOVYRATE® is a registered trademark.

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Novyrate® C

GRADUAL RELEASE

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Product Description Fiche Produit

NOVYRATE® C ®

Novyrate C

ObjetRelease Gradual (32% coated Sodium butyrate)

Le potentiel génétique de l’animal sans cesse plus performant induit un stress important au niveau de son système digestif entrainant généralement un processus d’absorption de nutriments inefficace ou sous optimisé. Cette sous-utilisation de l’aliment a un impact significatif sur la viabilité économique pour le producteur. Le butyrate de sodium est une molécule qui peut jouer un rôle crucial en participant à un meilleur équilibre de la flore intestinale.

Description

Pré-mélange. Une forme micro encapsulée de butyrate de sodium fabriquée avec soin afin d’assurer une libération lente et graduelle dans l'intestin.

Composants

Sels de sodium d’acide butyrique (32%), acides gras de source végétale

Spécifications

Aspect

: micro perles

Couleur

: blanc cassé

Densité

: 0,6 - 0,8 kg/l

pH (10%)

: 6-7

Humidité

: Max 5 %

Les changements de couleur du produit n’affectent en rien la performance.

Application et dose

Aliments: 0.5- 2,5 kg/T, Porcelets: 1,0 - 2,5 kg/T, Poulets de chair: 0,25 - 1,0 kg/T, Poules pondeuses: 0,5 - 1,0 kg/T, Dindes: 0,5 - 1,0 kg/T

Emballage

Sac standard en papier multicouches avec doublure intérieure PE de 25 kg sur des palettes en bois traité.

Durée de vie

2 ans emmagasiné correctement dans un endroit sec et frais dans son emballage d’origine.

APPLICATION & DOSE

Pigs Référence Produit 10042 Piglet Weaner kg fiche b.w.) 1,0sont – émises 2,0 kg/T L’information (5-12 reprise sur cette descriptive est correcte et juste. Toutes les instructions, recommandations et suggestions sous réserve. En effet, comme les conditions d’utilisation dépassent notre contrôle, le fabriquant ne peut être tenu responsable pour des pertes ou dommages liés à ces données, suggestions et recommandations. Piglet (Pre)-starter (12 -25 kg b.w.) 0,75 – 1,0 kg/T Sows (Barth care) 1,5 – 2,0 kg/T Sows (lactation) 1,0 – 1,5 kg/T Pig Grower I (25-35 kg b.w.) 0,5 – 0,75 kg/T Pig Grower II (35 – 55 kg b.w.) 0,35 – 0,5 kg/T Pig Finisher (55-110 kg b.w.) 0,25 kg/T

Poultry Broiler starter Broiler grower Broiler finisher Layer Breeder Turkey (0-6/8 w)

0,75 – 1,0 kg/T 0,500 kg/T 0,250 kg/T 0,5 kg/T 0,5 – 0,75 kg/T 1,0 kg/T

Calf Calf starer feed INNOV AD NV/SA

1,0 kg/T

Postbaan 69 2910 Essen - Belgium

F u n c t i o n a l

info@innovadglobal.com www.innovadglobal.com

N u t r i e n t s

F e e d

A d d i t i v e s

PDS/3 DATED 15-11-2011 NOVYRATE®

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Product Description Fiche Produit

® C C Novyrate NOVYRATE®

Gradual Release Objet

Le potentiel génétique de l’animal sans cesse plus performant induit un stress important au niveau de son système digestif entrainant généralement un processus d’absorption de nutriments inefficace ou sous optimisé. Cette sous-utilisation de l’aliment a un impact significatif sur la viabilité économique pour le producteur. Le butyrate de sodium est une molécule qui peut jouer un rôle crucial en participant à un meilleur équilibre de la flore intestinale.

Based on ‘Gradual Release’ coating-technology, supporting the animal in developing an optimal functioning intestinal tract, and targeting microbial imbalances . Description

Pré-mélange. Une forme micro encapsulée de butyrate de sodium fabriquée avec soin afin d’assurer une libération lente et graduelle dans l'intestin.

Composants

Sels de sodium d’acide butyrique (32%), acides gras de source végétale

Spécifications

Aspect

: micro perles

Couleur

: blanc cassé

Densité

: 0,6 - 0,8 kg/l

pH (10%)

: 6-7

Humidité

: Max 5 %

Target Release: Novyrate® C versus competitors

Les changements de couleur du produit n’affectent en rien la performance.

Application et dose

C1L

120

Aliments: 0.5- 2,5 kg/T, Porcelets: 1,0 - 2,5 kg/T, Poulets de chair: 0,25 - 1,0 kg/T, Poules

C1D NOVYRATE C kg/T pondeuses: 0,5 - 1,0 kg/T, Dindes: 0,5 ® - 1,0

Emballage

C2D

Sac standard en papier multicouches avec doublure intérieure PE de 25 kg sur des palettes en bois traité.

2 ans emmagasiné correctement dans un endroit sec et frais dans son emballage d’origine. No target 10042 Référence Produit release 100 complete L’information reprise sur cette fiche descriptive est correcte et juste. Toutes lesNo instructions, recommandations et suggestions sont émises sous réserve. En effet, comme les conditions d’utilisation dépassent notre contrôle, le fabriquant ne peut être tenu responsable pour des pertes ou dommages liés à ces release of 80 données, suggestions et recommandations. active ingredient NOVYRATE 60 100% bio-available 40

Durée de vie

20 0

T0

T1

T2

T3

Target release of NOVYRATE® C showing remaining active ingredient after different treatments: – T0: starting point – T1: pH 2 + pepsin addition (stomach) – T2: pH 6,8 + pancreatin (intestine) – T3: pH 7 + lipase (intestine) INNOV AD NV/SA Postbaan 69 2910 Essen - Belgium

36

F u n c t i o n a l

info@innovadglobal.com www.innovadglobal.com

N u t r i e n t s

F e e d

A d d i t i v e s

PDS/3 DATED 15-11-2011 NOVYRATE®

F a r m

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Fiche Produit

NOVYRATE® C Objet

Le potentiel génétique de l’animal sans cesse plus performant induit un stress important au niveau de son système digestif entrainant généralement un processus d’absorption de nutriments inefficace ou sous optimisé. Cette sous-utilisation de l’aliment a un impact significatif sur la viabilité économique pour le producteur. Le butyrate de sodium est une molécule qui peut jouer un rôle crucial en participant à un meilleur équilibre de la flore intestinale.

Description

Pré-mélange. Une forme micro encapsulée de butyrate de sodium fabriquée avec soin afin d’assurer une libération lente et graduelle dans l'intestin.

Composants

Sels de sodium d’acide butyrique (32%), acides gras de source végétale

Spécifications

Aspect

: micro perles

Couleur

: blanc cassé

Densité

: 0,6 - 0,8 kg/l

pH (10%)

: 6-7

Humidité

: Max 5 %

Les changements de couleur du produit n’affectent en rien la performance.

Application et dose

Aliments: 0.5- 2,5 kg/T, Porcelets: 1,0 - 2,5 kg/T, Poulets de chair: 0,25 - 1,0 kg/T, Poules pondeuses: 0,5 - 1,0 kg/T, Dindes: 0,5 - 1,0 kg/T

Emballage

Sac standard en papier multicouches avec doublure intérieure PE de 25 kg sur des palettes en bois traité.

Durée de vie

2 ans emmagasiné correctement dans un endroit sec et frais dans son emballage d’origine.

Référence Produit

10042

L’information reprise sur cette fiche descriptive est correcte et juste. Toutes les instructions, recommandations et suggestions sont émises sous réserve. En effet, comme les conditions d’utilisation dépassent notre contrôle, le fabriquant ne peut être tenu responsable pour des pertes ou dommages liés à ces données, suggestions et recommandations.

INNOV AD NV/SA Postbaan 69 2910 Essen - Belgium

info@innovadglobal.com www.innovadglobal.com

PDS/3 DATED 15-11-2011 NOVYRATE®

37


Novyrate® FP

PROTECTED

38


Product Description Product Data Sheet

NOVYRATE® ® FP FP Novyrate Scope (70% protected Sodium butyrate) Protected

The increasing animal genetic potential puts a significant stress on the animals’ digestive system, often leading to a suboptimal digestive process and nutrient absorption. The negative impact of sub-optimal feed utilization has a significant impact on the economical viability of the farm. Sodium butyrate is an important dietary component that can help balance and stimulate a healthy intestinal microflora.

Lipid-protected form of 70% pure Na-Butyrate, smell-neutral, and delivering high level of active component to optimize animal performance. Description

Complementary feed. A lipid-protected form of 70% pure Na-Butyrate, smell-neutral, and delivering high level of active component to optimize animal performance.

Components

Sodium Butyrate, Vegetable fatty acids.

Physical & Technical

Physical appearance

: granular powder

Specifications

Colour

: white or off white

Specific gravity

: 0,5 - 0,6 kg/l

pH (10%)

: 11,7 - 12,7

Moisture

: Max 2,5 %

Colour change or variation does not affect performance.

Application & Dosage

Piglets: 0,75 - 2 kg/T, Pigs (+ 25 kg): 0,25 - 0,75 kg/T, Sows: 1 - 2 kg/T, Broilers: 0,25 - 1 kg/T, Layers / Breeders: 0,5 - 0,75 kg/T, Turkeys: 0,5 - 1 kg/T

Packaging

Standard 25 kg export worthy bags in an outer carton on wooden fumigated pallets. Other net weights (1kg*, 5 kg*, 10 kg*, 25 kg, 750-1000kg, bulk) on demand. *Marked unit packs are packed in an outer carton up to max. 25 kg.

APPLICATION & DOSE

2 years when stored in a cool, well ventilated and dry environment out of direct sunlight in Shelf Life Pigs unopened packing. 10258 Item Reference Piglet Weaner (5-12 kg b.w.) 1,0 – 2,0 kg/T The information in this(12 data sheet the best of our knowledge true and accurate. All instructions, recommendations and suggestions made under Piglet (Pre)-starter -25is tokg b.w.) 0,75 – 1,0arekg/T reserve. Since the conditions of use are beyond our control, the manufacturer disclaims all liability for loss or damage suffered from the use of these data, suggestions or recommendations. Sows (Barth care) 1,5 – 2,0 kg/T Sows (lactation) 1,0 – 1,5 kg/T Pig Grower I (25-35 kg b.w.) 0,5 – 0,75 kg/T Pig Grower II (35 – 55 kg b.w.) 0,35 – 0,5 kg/T Pig Finisher (55-110 kg b.w.) 0,25 kg/T

Poultry Broiler starter Broiler grower Broiler finisher Layer Breeder Turkey (0-6/8 w)

0,75 – 1,0 kg/T 0,500 kg/T 0,250 kg/T 0,5 kg/T 0,5 – 0,75 kg/T 1,0 kg/T

Calf INNOV AD NV/SA Calf Milk Replacer Postbaan 69 2910 Essenfeed - Belgium Calf starer F u n c t i o n a l

info@innovadglobal.com www.innovadglobal.com

N u t r i e n t s

F e e d

A d d i t i v e s

1,0- 2,0 kg/T PDS/1 DATED 20-07-2012 NOVYRATE® is a registered trademark. 1,0 kg/T F a r m

P a c k s

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Product Data Sheet

NOVYRATE® FP Scope

The increasing animal genetic potential puts a significant stress on the animals’ digestive system, often leading to a suboptimal digestive process and nutrient absorption. The negative impact of sub-optimal feed utilization has a significant impact on the economical viability of the farm. Sodium butyrate is an important dietary component that can help balance and stimulate a healthy intestinal microflora.

Description

Complementary feed. A lipid-protected form of 70% pure Na-Butyrate, smell-neutral, and delivering high level of active component to optimize animal performance.

Components

Sodium Butyrate, Vegetable fatty acids.

Physical & Technical

Physical appearance

: granular powder

Specifications

Colour

: white or off white

Specific gravity

: 0,5 - 0,6 kg/l

pH (10%)

: 11,7 - 12,7

Moisture

: Max 2,5 %

Colour change or variation does not affect performance.

Application & Dosage

Piglets: 0,75 - 2 kg/T, Pigs (+ 25 kg): 0,25 - 0,75 kg/T, Sows: 1 - 2 kg/T, Broilers: 0,25 - 1 kg/T, Layers / Breeders: 0,5 - 0,75 kg/T, Turkeys: 0,5 - 1 kg/T

Packaging

Standard 25 kg export worthy bags in an outer carton on wooden fumigated pallets. Other net weights (1kg*, 5 kg*, 10 kg*, 25 kg, 750-1000kg, bulk) on demand. *Marked unit packs are packed in an outer carton up to max. 25 kg.

Shelf Life

2 years when stored in a cool, well ventilated and dry environment out of direct sunlight in unopened packing.

Item Reference

10258

The information in this data sheet is to the best of our knowledge true and accurate. All instructions, recommendations and suggestions are made under reserve. Since the conditions of use are beyond our control, the manufacturer disclaims all liability for loss or damage suffered from the use of these data, suggestions or recommendations.

INNOV AD NV/SA Postbaan 69 2910 Essen - Belgium

40

info@innovadglobal.com www.innovadglobal.com

PDS/1 DATED 20-07-2012 NOVYRATE® is a registered trademark.


41


TRIAL REVIEW

42


Trial Review

Scientific Experiment with piglets Date & Location: April – June 2012. Katholieke Universiteit Leuven, Belgium. Zootechnical Centre Lovenjoel Species: Piglets

Protocol: Trial period from Day 21 (weaning) until Day 67 of age (46 days) Trial was performed with Mash Feed & Pelleted Feed (Ø 2.3mm) Negative Control vs.NOVYRATE EB (2+1) 2 kg/ton NOVYRATE® EB in Weaning stage (21-35 days) 1 kg/ton NOVYRATE EB® in Prestarter-feed (35-67 days) Results AVERAGE DAILY WEIGHT GAIN

FEED CONVERSION RATIO

F u n c t i o n a l

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Trial Review

Field Trial with growing pigs Date & Location: March - May 2012. Italy Species: Growing Pigs

Protocol: 352 pigs (growing pigs 50 â&#x20AC;&#x201C; 90 kg) Control versus NOVYRATEÂŽ EB @ 2kg/MT Historical issue on Red Diarrhea, but no occurence during trial Parameters checked: Live weight Average Daily Gain Mortality

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Innovad nv/sa Sales & Customer Services : Cogels Osylei 33, 2600 Berchem, BELGIUM Production & Laboratory : Postbaan 69, 2910 Essen, BELGIUM Tel. +32(0) 3 667 16 55 www.innovad-global.com info@innovad-global.com

© 2016 by Innovad®. All rights reserved. Code: NOVBROEN (28.10.2016)

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Novyrate – Optimal solution that supports Gut Integrity

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