VOLUME 2 NO 4.
A B2B E-COMMERCE PLATFORM providing nutritional raw materials for the dietary supplement, food & beverage, cosmetic and animal nutrition industries
Meet the ingredientsonline.com team at these events
Las Vegas, NV Booth: KK142
Rosemont, IL Booth: 768
IFT Suppliers Night – Chicago
Hilton Rosemont/Chicago O'Hare
Mumbai, India Booth: C38
Frankfurt, Germany Booth: 08.0S32
ingredientsonline.com Chicago RoadShow
FI & HI – India
GLOBAL FACTORY-DIRECT MARKETPLACE A B2B e-commerce platform providing nutritional raw materials for the dietary supplement, food & beverage, cosmetic and animal nutrition industries
he ingredientsonline.com factory-direct e-commerce platform will save billions of dollars in broker and distributor fees. Our Amazon.com-like platform provides radical transparency on quality control documents, real-time U.S. inventory in Calif., N.J. and Fla., tiered factory-direct pricing and clearly identified factory of origin.
With FSMA implementation, knowing the original source of all ingredients is mandatory, and ingredientsonline.com is the solution. For each ingredient page, you can always see the original factory source at your fingertips, 24/7. This feature provides you with the necessary details to be FSMA/FSVP compliant. In addition to FSVP, PCQI is another FSMA requirement, and we are pleased to announce that ingredientsonline.com is sponsoring Larisa Pavlick, UNPA's VP of Global Regulatory and Compliance, at SupplySide West. Hear Larisa's session — Understanding How FSMA & PCQI Impact Your Supply Chain — at the SupplySide Central Stage on Wednesday, Sept. 27, from 2:00-2:30 p.m. You can also hear Sherry Wang, Founder and President of ingredientsonline.com, along with Peggy Jackson, VP of Sales & Marketing, close the session with a few comments on the importance of traceability and transparency in the supply chain.
Want to learn more about ingredientsonline.com? Call to schedule a meeting with an executive team member, email for an online demo or see us at an upcoming event (event calendar on page 24).
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Hello and welcome to our SupplySide West and anniversary fall issue
CONTENTS Ingredients Listing................................ 6 Quality Control Corner....................... 10 Regulatory Perspectives.............14 & 22
One year ago, we published our first ingredientsonline.com Magazine. It’s been a great experience and I hope you’ve enjoyed the content. Be sure to subscribe so you can continue to receive upcoming issues.
Market Trends........................................16 Testimonials.......................................... 20
Two years ago, we launched the ingredientsonline.com website - the Global Factory-Direct Marketplace connecting B2B buyers and sellers with nutritional ingredients. This year at SupplySide West, please join us for an anniversary toast. This celebration will commence with happy hour from 3:30 -5:00 p.m. on Wednesday, Sept. 27, at the ingredientsonline.com booth, KK142. Also taking place at SupplySide West, we are pleased to be sponsoring the session Understanding How FSMA & PCQI Impact Your Supply Chain. Joins us and hear Larisa Pavlick, UNPA's VP of Global Regulatory and Compliance, discuss this very important topic at the SupplySide Central Stage on Wednesday, Sept. 27, from 2:00-2:30 p.m. In addition, we will deliver closing remarks with vital information on the importance of traceability and transparency in the supply chain. I would also like to invite you to meet your factory at SupplySide West. With ingredientsonline.com, we provide full transparency with factory of origin for all ingredients, and we are happy to arrange a meeting for you and any of our factorydirect partners. Email us at email@example.com and we will make those arrangements at our booth, KK142.
Events Calendar ................................... 24 Ingredient News................................... 28 Global Sourcing Events....................... 30 Roadshow Recap....................................31
PROUD MEMBERS OF THESE LEADING INDUSTRY ASSOCIATIONS!
We have new online features and benefits including Show me the Savings and Repack. We also have new tutorials; a quick guide to common online functions. Be sure to check out these details on page 5. After SupplySide West, I’ll be on the road again this fall looking for more quality factordirect partners. I’ll be in China, India and Europe, and I hope to meet you at an upcoming event. Be sure to stop by Booth KK142 at SupplySide West.
American Herbal Products Association
National Association of Flavors and Food-Ingredient Systems Sherry Wang Founder and President ingredientsonline.com
National Animal Supplement Council
United Natural Products Alliance
TECHNOLOGY & TRANSPARENCY IN SUPPLY CHAIN SOURCING Offering a continuous supply of consistent quality ingredients from approved global factories of origin.
FACTORY-DIRECT PRICING Partnering directly with approved global factories allows for factory-direct pricing which saves you on broker and distributor fees. Each ingredient listing displays tiered pricing based on volume where you choose your desired quantity and price. Need larger volumes and better pricing? No problem. Click on the High Volume button.
QA/QC DOCS All documents and certificates are reviewed to ensure they meet our standards prior to listing them online. Each ingredient listing clearly displays all documentation in PDF form. Simply click to download any document, any time, 24/7.
FACTORY OF ORIGIN Knowing the original source of all ingredients is now mandatory to be FSMA/FSVP compliant. All approved factories of origin are visibly transparent for every ingredient and at your fingertips, 24/7. Plus, consistent quality is as important as maintaining exceptional quality. Part of our quality control program includes keeping records of all approved factories of origin and tracking each customer's preferred factory requestsâ€‹.
U.S. INVENTORY Every ingredient page clearly lists the real-time U.S. inventory. You choose which warehouse to order from: Calif., N.J., Miami, or our new Dallas location opening this fall. Watch for additional warehouses in Salt Lake City and Chicago opening soon.
SAVE TIME & SAVE MONEY SHOP NOW at INGREDIENTSONLINE.COM
FACTORY-DIRECT PRICING GLOBAL SOURCING CENTER ADDITIONAL BENEFITS
HIGH VOLUME OFFER
SHOW ME THE SAVINGS!
The ingredientsonline.com platform offers quantities large and small. If you do not see your desired volume within the Tiered Pricing section, no problem. Simply click on the High Volume Offer button and complete the form. We will work directly with the factory for pricing on your desired amount including containers.
INVENTORY PROTECTION PROGRAM Customers who provide their NO OBLIGATION projections can rest assured we will hold U.S. inventory for you (subject to our final approval, availability and confirmation). There’s absolutely NO RISK! Email firstname.lastname@example.org.
EDUCATION The ingredientsonline.com platform is easy to use and we offer print, online and in-person educational opportunities. Visit the Info Center tab in the navigation bar to learn basic functions of the interactive platform. Attend one of our upcoming Global Sourcing Events (see page 24 for details) to learn more about ingredientsonline.com and current industry QC and regulatory updates.
We received many requests to provide the "amount saved" when placing an order and taking advantage of Tiered Pricing. Now you will automatically see your savings on the Shopping Cart screen during checkout. This is just one feature that clearly shows how the ingredientsonline.com platform saves you both time and money.
REPACK IS NOW AVAILABLE Take advantage of this new online benefit and get the exact quantity you need. There are many reasons you may need smaller quantities of many popular ingredients. Perhaps you’re doing a pilot run or maybe you’re filling a larger order but only need a few additional kilos, not the standard 25. Repack is the solution! This new Repack feature allows for the exact quantity you need, so go online now and take advantage of this new feature.
MARKET TRENDS On many popular ingredients, look for the arrow next to the price $/kg. This feature speculates upcoming rising or decreasing prices. See the Market Trends article on page 16 for more details. Questions? Email email@example.com.
Sign up at ingredientsonline.com to reveal the benefits of Complete Transparency
5'-CMP 5'-GMP 2Na 5-HTP 5'-UMP 2Na 7-Methoxy Flavone
A____________________ Acesulfame K Acetyl L-Carnitine HCL Agmatine Sulfate Alfalfa Powder Aloe Vera Extract Alpha Cyclodextrin Alpha GPC Alpha Keto Glutaric Acid Alpha Lipoic Acid Alpha Lipoic Acid R Version Alpha Lipoic Acid Sodium Alpha Lipoic Acid Sodium R Version Apple Cider Vinegar Powder Apple Juice Powder ARA CWS Ascorbic Acid Ascorbic Acid Coated Ascorbic Acid DC97 Ascorbyl Palmitate Aspartame Astaxanthin Beadlet Astaxanthin Oil Astaxanthin Powder Astragalus P.E.
B____________________ Bacopa Extract Barley Grass Powder (Organic) Barley P.E. BCAA Granular BCAA Instant BCAA Regular Bearberry Leaf Extract Benfotiamine Berberine HCl Beta Carotene Beadlet Beta carotene Powder Beta Cyclodextrin Beta Glucan Betaine Anhydrous Betaine HCl Betaine Liquid Bilberry Extract Biotin (Vitamin H) Bitter Melon Extract Black Currant Extract Black Currant Fruit Powder Black mulberry fruit P.E. Black mulberry fruit Powder Black Rice Extract Black Tea PE Blueberry Extract Blueberry Fruit Powder
Blueberry Juice Powder Boswellia Serrata P.E. Bovine Collagen Powder Broccoli Extract Broccoli Powder Butcher's Broom Extract
C____________________ Caffeine Anhydrous Synthetic Calcium Ascorbate Calcium Ascorbate DC97 granular Calcium Beta Hydroxybutyrate Calcium Carbonate DC95 Calcium Carbonate Powder Calcium Citrate DC97 Granular Calcium Citrate Powder Calcium Orotate Calcium Pyruvate CD Inland Sea Water (Liquid) CD Inland Sea Water (Powder) Chlorella (Broken Cell) Choline Chloride Choline Chloride Liquid Choline Dihydrogen Citrate Choline DL-Bitartrate Choline DL-Bitartrate Coated Choline L-Bitartrate Choline L-Bitartrate Coated Chondroitin Sulfate Chrysin Cinnamon P.E. Citicoline Sodium Citric Acid CLA EE Softgel CLA FFA Oil CLA FFA Powder CLA FFA Softgel CLA TG Powder Coenzyme Q10 Copper Citrate Copper Gluconate Cordyceps Sinensis P.E. Cranberry Extract Cranberry Fruit Powder Cranberry P.E. Creatine Anhydrous Creatine Citrate Creatine Ethyl Ester HCL Creatine Gluconate Creatine HCL Powder Creatine Monohydrate Creatine Monohydrate Granular Creatine Monohydrate Instant Creatine Pyruvate Creatinol-O-Phosphate Creek Yellow Grass Cuminum Cyminum Curcuminoids Cyanocobalamin
D____________________ D-Alpha Tocopherol Oil D-Alpha Tocopheryl Acetate D-Alpha Tocopheryl Succinate Dandelion Extract Dandelion Root P.E. D-Aspartic Acid D-Calcium Pantothenate DCP Dihydrate DCP Dihydrate Granular DHA DHEA DiCalcium Phosphate Dihydrate DiCreatine Citrate Diindolylmethane DL-Alanine DL-Malic Acid DL-Methionine DL-Phenylalanine DMAE DL- Bitartrate DMAE L- Bitartrate D-Mannose DMG HCL B15 D-Panthenol D-Pinitol D-Xylose
E____________________ Echinacea Purpurea P.E. Erythorbic Acid Erythritol Ethyl Maltol Ethyl Vanillin
F____________________ Ferrous Fumarate Ferrous Gluconate Dihydrate Ferrous Lactate Powder Flaxseed Oil Powder Folic Acid Fructo Oligosaccharide Liquid Fructo Oligosaccharide Powder Fucoidan Fucoxanthin Fumaric acid
G____________________ GABA Galacto Oligosaccharide LIQ Galacto Oligosaccharide Powder Galla Chinensis P.E. Gamma Oryzanol Garcinia Cambogia P.E Garlic Extract Ginger Powder(Organic) Ginger Root Extract Ginkgo Biloba Extract
Ginkgo Biloba Leaf Extract Glucomannan Glucosamine HCL Glucosamine HCl DC Glucosamine Sulfate 2KCl Glucosamine Sulfate 2KCl DC Glucuronolactone Glycerine Glycerol Monolaurate Glycerol Monostearate Grape Seed Extract Green Coffee Bean P.E. Green Tea Extract
H____________________ Hawthorn Berry P.E. Hawthorn Extract High Fructose Syrup Holy Basil Powder Horny Goat Weed Extract Horny Goat Weed Extract (Organic) Huperzine A Hydrolyzed Fish Collagen 2000 HydroxyPropyl Methyl Cellulose
I_____________________ Indole-3-Carbinol Inosine Inositol Inositol DC95 Granular Inositol Hexaphosphate Powder Inositol Nicotinate Inulin Ipriflavone Isomalto-Oligosaccharides Ivy P.E.
J_____________________ Japanese Thistle P.E.
K____________________ Kudzu Root Extract
L_____________________ Lactic Acid Powder Lactisole L-Alanine L-Arabinose L-Arginine L-Aspartate L-Arginine (Fermentation) L-Arginine AKG Dihydrate L-Arginine HCL Regular L-Arginine HCl (Fermentation) L-Ascorbate-2-Phosphate L-Aspartic Acid L-Calcium Lactate
SHOW ME THE SAVINGS! This is a new feature that shows the amount saved when placing an order and taking advantage of Tiered Pricing. Now you will automatically see your savings on the Shopping Cart screen during checkout. This is just one feature that clearly shows how ingredientsonline.com saves you both time and money!
INGREDIENTSONLINE.COM â€¢ FALL 2017
L-Carnitine Base L-Carnitine Fumarate L-Carnitine HCL L-Carnitine Tartrate L-Carnosine L-Citrulline L-Citrulline DL-Malate L-Cysteine (Vegan) L-Cysteine HCl Anhydrous L-Cysteine HCL Anhydrous (Vegan) L-Cysteine HCl Monohydrate L-Cysteine HCL Monohydrate (Vegan) L-Cystine Lemon Balm Extract Lemon Powder L-Glutamic Acid L-Glutamic Acid Hydrochloride L-Glutamine L-Glutathione Reduced L-Histidine Base L-Histidine HCL Monohydrate L-Hydroxyproline Lion's Mane Mycelium Extract Liquorice Extract L-Isoleucine L-Isoleucine Granular L-Isoleucine Instant L-Leucine Fermentation L-Leucine Instant L-Leucine Regular L-Lysine Mono HCL L-Lysine Mono HCL Granular L-Methionine L-Norvaline Longjack P.E L-Ornithine Mono HCL L-Phenylalanine L-Proline L-Pyroglutamic Acid L-Serine L-Theanine L-Threonine L-Tryptophan L-Tryptophan Granular L-Tyrosine Luo Han Guo Extract Lutein Lutein Beadlet Lutein Oil L-Valine L-Valine Instant Lycopene
M____________________ Maca Extract Maca Powder Magnesium Ascorbyl Phosphate Magnesium Beta Hydroxybutyrate Magnesium Carbonate Heavy Magnesium Citrate Anhydrous Magnesium Citrate Granular Magnesium Citrate Powder Magnesium Gluconate Dihydrate Magnesium Glycinate Magnesium Lactate Powder Magnesium L-Aspartate Magnesium Orotate Magnesium Oxide Powder Magnesium Stearate Maltitol
Maltodextrin Maltol Manganese Gluconate Mangosteen Mangosteen Fruit Powder Mannitol Marshmallow P.E. Massularia Acuminata Extract MCH Hydroxyapatite MCT Powder Melatonin Menthol Methyl Cyclopentenolone Methylcobalamin Microcrystalline Cellulose Milk Thistle Milk Thistle P.E. Mixed Tocopherol Moringa Leaf Extract Moringa Leaf Powder MSM MSM Granular Mucuna Pruriens P.E.
GRAPE SEED P.E. 95%
Starting material: Grape seeds from Europe
Guarantee high oligomeric proanthocyanidins content
Capacity up to 500 tons annually
Largest Grape Seed Extract factory in the world
N&A Blue Raspberry Flavor N&A Fruit Punch Flavor N&A Watermelon Flavor N-Acetyl D-Glucosamine N-Acetyl L-Cysteine N-Acetyl L-Cysteine (Fermented) N-Acetyl L-Tyrosine Nattokinase Neotame Niacin (B3) Niacinamide (B3)
• Grape Seed Extract
Olive Leaf P.E. Organic Bilberry Extract Orotic Acid Anhydrous Orotic Acid Monohydrate
Green Coffee Bean Extract
Red Yeast Rice
P____________________ PABA Panax Ginseng Extract Parsley Leaf Powder Pea Protein Peppermint Oil Phenibut HCL Crystalline Phenibut HCL Powder Phosphatidyl Serine Phytosterol Picolinic Acid Pine Bark Extract Pineapple Juice Powder Policosanol Polydextrose Polyglycerol Esters Of Fatty Acids Pomegranate Juice Powder Pomegranate P.E. Portulaca Oleracea P.E. Potassium Bicarbonate Potassium Carbonate Potassium Chloride Potassium Gluconate Potassium L-Aspartate Potassium Orotate
Chenguang Biotech Group Co., Ltd (CCGB, Stock Code 300138) is the leading manufacturer and supplier of plant extracts across the world, is listed in China’s Top Five Export Enterprise of plant extracts and is the recognized largest global supplier of Paprika Oleoresin, Capsicum Oleoresin. CCGB is certified by CNAS, ISO9001, ISO22000, ISO14001, OHSAS18001, KOSHER, HALAL, FAMI-QS, CMS, SEDEX and FDA registered.
CHENGUANG BIOTECH GROUP CO., LTD SHOP NOW at chenguang.ingredientsonline.com INGREDIENTSONLINE.COM • FALL 2017
Potassium Sorbate Granular Povidone K-30 PQQ Disodium Salt Propylene Glycol Purple Sweet Potato Pigment Pyridoxal 5 Phosphate Pyridoxine (B6) HCL Powder Pyrroloquinoline Quinone
Q_________________ Quercetin Dihydrate
R_________________ Raspberry Fruit Powder Raspberry Ketone Red Beet Root Powder Red Clover P.E. Red Pitaya Fruit Powder Red Raspberry Extract Red Yeast Rice P.E. Reishi P.E. Resveratrol Rhodiola P.E. Rhodiola Rosea P.E. Riboflavin (Vitamin B2) Riboflavin 5 Sodium Phosphate Ribonucleic Acid Rice Protein Rosemary Extract Rutin
S-Acetyl-L-Glutathione SAMe Tosylate Disulfate Schisandra P.E. Sea Berry Pure Fruit Powder Shiitake Mushroom Extract Siberian Ginseng Extract Silicon Dioxide Sodium Acid Pyrophosphate Sodium Ascorbate Sodium Ascorbyl Phosphate Sodium Benzoate Granular Sodium Benzoate Powder Sodium Beta Hydroxybutyrate Sodium Citrate Sodium Copper Chlorophyllin Sodium Gluconate Sodium Hyaluronate Sodium Lactate Powder Sodium Saccharin Sodium Starch Glycolate Sodium Tripolyphosphate Sorbitol Powder Soy Lecithin Soy Protein Isolate Spirulina (Organic) St John's Wort P.E. Star Anise P.E. Stevia P.E Sucralose Sulbutiamine Sweet Tea Extract
Tartaric Acid Taurine Tetrasodium Pyrophosphate Theobromine Thiamine HCL Thiamine Mononitrate Titanium Dioxide TPGS Trehalose Tribulus P.E Trimagnesium Phosphate Turmeric Oil Turmeric Root P.E. Turmeric Root Powder TwinTiger Glutathione Reduced
V_________________ VA Acetate Powder Valerian Extract Vanillin VD3 Powder Vit.A Palmit Oil 1,700,000iu/g Vitamin A Palmitate 250,000iu Vitamin D3 CWS Powder 100,000iu/g Vitamin D3 Oil 1,000,000iu/g Vitamin E Acetate Oil Vitamin E Powder Vitamin K1 Oil Vitamin K1 Powder Vitamin K2 MK-4 Oil
ZHENGZHOU TUOYANG INDUSTRIAL CO.,LTD.
Ascorbic Acid 40-80 Mesh Ascorbic Acid 100 Mesh
Zhengzhou Tuoyang Industrial Co.,Ltd. was established in 1993 and is a famous professional manufacturer specializing in food additives and medical medium. It has ISO, HACCP, OHSAS18001, Kosher and BRC certifications.
SHOP NOW at tuoyang.ingredientsonline.com
Vitamin K2 MK-7 Oil Vitamin K2 MK-7 Powder Vitamin U VitaminK2 MK-7 1.0% PD (Natural)
W_________________ Whey Protein Concentrate Whey Protein Instant White Peony Root PE White Tea Extract White Willow Bark P.E. Wild Yam Extract Wolfberry P.E.
X_________________ Xanthan Gum Xylitol Xylitol DC
Z_________________ Zeaxanthin Zeaxanthin Beadlet Zeaxanthin Oil Suspension Zinc Carnosine Zinc Citrate Powder Zinc Gluconate Dihydrate Zinc Glycinate Zinc Lactate Powder Zinc Oxide
DID YOU KNOW?
ingredientsonline.com now offers over 150 herbal ingredients With factory-direct prices, complete transparency of QC documents and real-time U.S. inventory, these herbal ingredients can add to your cost savings and efficiencies. Go online now and compare the factory-direct prices – ingredientsonline.com
Alfalfa Powder Aloe Vera Extract Astragalus P.E.
Galla Chinensis P.E. Garcinia Cambogia P.E Garlic Extract Ginger Powder (Organic) Ginger Root Extract Ginkgo Biloba Extract Ginkgo Biloba Leaf Extract Grape Seed Extract Green Coffee Bean P.E. Green Tea Extract
B________________________ Bacopa Extract Barley Grass Powder (Organic) Barley P.E. Bearberry Leaf Extract Bilberry Extract Bitter Melon Extract Black Currant Extract Black Currant Fruit Powder Black Mulberry fruit P.E. Black Mulberry fruit PW Black Rice Extract Black Tea PE Blueberry Extract Blueberry Fruit Powder Blueberry Juice Powder Boswellia Serrata P.E. Broccoli Extract Broccoli Powder Butcher's Broom Extract
H________________________ Hawthorn Berry P.E. Hawthorn Extract Holy Basil Powder Horny Goat Weed Extract Horny Goat Weed Extract (Organic) Huperzine A
I_________________________ Inulin Ivy P.E.
J_________________________ Japanese Thistle P.E.
Chrysin Cinnamon P.E. Cordyceps Sinensis P.E. Cranberry Extract Cranberry Fruit Powder Cranberry P.E. Creek Yellow Grass Cuminum Cyminum Curcuminoids
D________________________ Dandelion Extract Dandelion Root P.E.
E________________________ Echinacea Purpurea P.E. Evodiamine
F________________________ Flaxseed Oil Powder Fucoidan Fucoxanthin
K________________________ Kudzu Root Extract
L_________________________ Lactic Acid Powder Lemon Balm Extract Lemon Powder Lion's Mane Mycelium Extract Liquorice Extract Longjack P.E Luo Han Guo Extract Lutein Lutein Beadlet Lutein Oil
M________________________ Maca Extract Maca Powder Mangosteen Mangosteen Fruit Powder Marshmallow P.E. Massularia Acuminata Extract
Menthol Milk Thistle Milk Thistle P.E. Moringa Leaf Extract Moringa Leaf Powder Mucuna Pruriens P.E.
O________________________ Olive Leaf P.E. Organic Bilberry Extract
P________________________ Panax Ginseng Extract Parsley Leaf Powder Pea Protein Peppermint Oil Phytosterol Pine Bark Extract Pineapple Juice Powder Pomegranate Juice Powder Pomegranate P.E. Portulaca Oleracea P.E. Purple Sweet Potato Pigment
Q________________________ Quercetin Dihydrate
Raspberry Fruit Powder Raspberry Ketone Red Beet Root Powder Red Clover P.E. Red Pitaya Fruit Powder Red Raspberry Extract Red Yeast Rice P.E. Reishi P.E. Resveratrol Rhodiola P.E. Rhodiola Rosea P.E. Rosemary Extract Rutin
Tribulus P.E Turmeric Oil Turmeric Root P.E. Turmeric Root Powder
V________________________ Valerian Extract
S________________________ Schisandra P.E. Sea Berry Pure Fruit Powder Shiitake Mushroom Extract Siberian Ginseng Extract St John's Wort P.E. Star Anise P.E. Stevia P.E Sweet Tea Extract
White Peony Root PE White Tea Extract White Willow Bark P.E. Wild Yam Extract Wolfberry P.E.
Z________________________ Zeaxanthin Zeaxanthin Beadlet Zeaxanthin Oil Suspension INGREDIENTSONLINE.COM • FALL 2017
QUALITY CONTROL CORNER
THE TAO OF
BOTANICAL TESTING Author Elan Sudberg, CEO, Alkemist Labs
s the dietary supplements industry grows and matures, there are inherent challenges we face. Most criticisms leveled at the industry by the media, State Attorneys General, the FDA and others have to do with quality and how that’s both defined and ensured. In our 20 years in business, one thing has never changed: a good testing lab is a gatekeeper for quality. What, then, do you need to know to help your lab help you prove your quality?
Identity & GMP Compliance At the heart of regulatory compliance and providing safe and effective products to consumers is a basic question: What is it? Knowing what is expected is key to cGMP compliance. The rules state that a scientifically valid method must be used to assess the identity of a product and be sure label claim is met, but they don’t state exactly what methods are to be used. With identity testing being the first step of GMP compliance for botanicals, the identification aspect has to be very well thought out from beginning to end, from plant identification to record keeping. Traditionally, experienced herbalists relied on organoleptic identification of herbs: looking at it, smelling it and tasting a plant to confirm identify. Regarding the validity of organoleptic identification, the FDA says only when performed in a scientifically valid manner alongside legitimate training records proving the expertise employed, can this age-old technique be utilized. Obviously, this isn’t an option for powdered herbs, which is why a lab needs to be
INGREDIENTSONLINE.COM • FALL 2017
Élan M. Sudberg is CEO of Alkemist Labs; a passionately committed contract testing laboratory specializing in plant authentication, botanical ingredient identification and quantitative analytical services to the Food & Beverage, Nutraceutical and Cosmeceutical Industries. He holds a degree in chemistry from California State University, Long Beach, and has authored numerous journal articles on phytochemistry and analytical techniques for the Natural products and Nutraceutical industry. He is a board member of AHPA as well as AHPA’s Education and Research on Botanicals Foundation, and former chair of the Hemp and Medical Marijuana committee.
brought in here. And depending upon the herb, if it’s a likely subject for adulteration, identity testing is imperative. While there has always been a testing component to cGMP compliance for dietary supplement manufacturers, New York Attorney General Eric Schneiderman brought it to the attention of people outside the GMP compliance department. His criticisms aside, we’ve seen a definite correlation over the last 20 years between our year after year growth and adherence to GMP compliance. Schneiderman’s attention created interest in understanding the nuts and bolts of testing, particularly test methods and technologies. That has led to conversations about which test methods to use, and our answer, every time, is that it always comes down to what is fit for purpose.
Fit For Purpose Test Methods We all experienced the uproar based upon testing methods neither scientifically valid nor yet fit for purpose - the two cardinal rules upon which accurate testing is founded. While DNA barcode testing has a place in the pantheon of testing methods when performed by trained experts who understand the kinds of substances they are working with, it just can’t give accurate results on extracts because the commercial extraction process leaves little or no actual plant tissue, degrading DNA while leaving the actives present. It also doesn’t quantify, so the traces of substances not on the label like rice via excipients - are identified but not quantified. DNA is also not capable of plant part differentiation, which is critical to an accurate ID. Obviously DNA testing alone will not provide the
vital information you are required to obtain. The World Health Organization and other government and non-profit organizations, including the U.S. Pharmacopeia and American Herbal Pharmacopeia, have published extensively on which methods are best for ensuring the quality of botanical materials which includes identity testing. Examples of critical tools for botanical identity verification are Botanical Microscopy, HPTLC/ MS and HPLC fingerprinting and botanical reference standards. Chromatography – both TLC and HPLC – have been proven to be effective tools for helping the industry to unravel the complex chemistry of botanical products, thus proving quality and identity. Chromatography is very often appropriate for many of the samples that cross our lab benches, and as we continue to guide clients towards the right testing, HPLC and TLC are frequently part of the equation. The usual tests a competent lab would perform for identity testing for finished products would include a purposeful combination of high performance liquid chromatography (HPLC) fingerprint analysis or high performance thin layer chromatography (HPTLC). While they do have some limitations, these methods have stood the test of time and are accepted by government agencies like the FDA, Australia’s TGA and Health Canada, among many others. In my experience, these tests work extremely well in the hands of specifically trained technicians who are committed to accurate results.
THE BIGGEST MANUFACTURER OF Turmeric Extract and Huperzia Serrata Extract Ningbo Herb is a high-tech manufacturing enterprise specializing in proprietary Chinese medicine APIs and natural plant extracts. With a strong commitment to quality control and adhering to strict GMP standard, Ningbo Herb owns drug, food and food additive production licenses. Ningbo Herb strictly controls every step from raw material selection, production and packing, until the product is delivered. Owners of 6 million m2 Turmeric raw material planting base with GAP standards, Ningbo Herb can supply 300 tons of Turmeric Extract 95% and 2000 tons of Turmeric powder annually.
• Curcuminoids 95%
• Grape Seed Extract OPC 95% & Polys 80%
• Curcuminoids 95% (Bisdemethoxy Curcumin+Demethoxy Curcumin 50%)
• Grape Seed Extract OPC 95% & Polys 75%
• Curcuminoids 95% Granular
• Rhodiola Rosea Extract Rosavins 3% & Salidrosides 1%
• Curcuminoids 15%/40% (HBA Grade)
• Rhodiola Rosea Extract Rosavins 5% & Salidrosides 3%
• Curcuminoids 2%/5%
• Ginkgo Biloba Extract CP2015
• Turmeric Root Powder E5-E32
• Ginkgo Biloba Extract USP-NF
• Turmeric Oil
• Ginkgo Biloba Extract 20:1
• Turmeric Oleoresin E200
• Black Mulberry Extract Anthocyanins 25%
• Huperzia Serrata Extract Huperzine-A 1.0-5.0%
• Black Mulberry Powder Anthocyanins 1-2%
• Grape Seed Extract OPC 95% & Polys 85%
• Mucuna Pruriens Extract L-dopa 15%-99%
Ningbo Traditional Chinese Pharmaceutical Corp.
www.ningboherb.com USA Mob:+1-626-363-3319 Email: Helen@ningboherb.com
No. 525, Yuanbaoshan Road, Beilun District, Ningbo, China Tel:+86 574- 8611-1716 Fax:+86 574- 8611-5767 Milly@ningboherb.com
QUALITY CONTROL CORNER
Extracts and Testing 101
For botanical extracts, it is critical to know what you are measuring. Botanical extracts contain a chemical profile or fingerprint, and depending on what solvents are used, that profile or fingerprint can change significantly.
Phytochemical reference standards are highly purified substances used in natural product testing. Their proper selection and use directly impacts the ability to assess the safety, quality and potency of both raw materials and finished products. Botanical reference materials are plant biomass materials that have been authenticated through a variety of analytical techniques such as macroscopic verification, microscopic identification and HPTLC. These materials are critical tools that help the industry meet cGMP ingredient identification requirements for botanical raw materials.
Each morning I make an extract using hot water and ground Coffea Arabica seeds, otherwise known as espresso. If I were making a botanical extract for a dietary supplement, I'd then dry this liquid extract into a powder. Because water was used as the solvent, in science terms, it pulls out polar phytochemicals from the seeds and leaves behind others. That’s what we drink in our coffee, a solution mostly of water, pigments and polar compounds. To test botanical extracts, you need to know what to look for. One easy and time-tested way is to compare the test sample to a reference sample of verified authenticity. That reference sample must be treated and prepared in the same way as the test sample in order to accurately compare the two. This is best done via high performance, thin layer chromatography (HPTLC) because it does comparative chemical fingerprinting. While HPTLC is more than adequate, the other technique commonly used to ID a botanical extract is HPLC. HPLC is far more complicated and expensive to run and requires use of phytochemical standards or reference materials to compare and contrast a phytochemical fingerprint. An important point to note is that HPLC is designed to quantify and not to qualify. Methods are readily available to quantify the caffeine in your samples of Green Tea, however, the presence of caffeine does not mean you have Green Tea leaf, rather, you have something that has caffeine in it. It is not uncommon that HPLC is improperly used to assess the ID of a test sample. Saw dust spiked while caffeine might pass. Sometimes, those who use HPLC fingerprinting to ID a botanical do so because they have access to HPLCs and not HPTLC equipment. It’s a good question to ask those testing your botanical ingredients. While HPTLC can successfully confirm the presence of specific botanical ingredients in a finished product, there are limitations with all methods, and one that confounds HPTLC is the practice 'fairy dusting.' Throwing in a smidgen of these and those ingredients just so they can be put on the label without offering therapeutic doses is not only unethical, it complicates testing.
INGREDIENTSONLINE.COM • FALL 2017
Finished Product Formula Testing You can’t test quality into a product, you have to build it into the formula, which takes more than quality ingredients in therapeutic amounts. Establishing how it will be tested should be part of the process, and choosing time-tested ingredients will simplify the process.
What happens when a material fails testing? There is a learning curve when ramping up a robust testing program. For those in the early stages of doing so, an important thing to learn is how to handle a failed sample: the first priority is to identify why. No one wants a failed sample, but the fact of the matter is, it happens. A positive result of all the negative publicity that the NY Attorney General sparked several years ago was that the number of companies finally starting to test their incoming ingredients and finished products more accurately, or at all, has been increasing. Understandably, this growth in the number of products we’re testing has increased the rate of sample failures we have been finding, giving rise to a lot of perplexed companies trying to figure out what the problem is and if they are doing things according to the cGMP’s, 21 CFR part 111 for dietary supplements. A sample can fail to meet spec for botanical ID analysis or quantitative analysis. Whenever we fail a sample, it is frustrating and time consuming for all parties involved while we get to the bottom of the failure.
Methods do not exist for complicated finished products until they are developed. Testing the caffeine content in Green Tea is fairly simple. Testing the caffeine in a product mixed with several other ingredients requires custom method development for a custom formula.
As an Analytical Testing Lab that has dealt with these problems for many years, we have a fairly rigorous method of investigating failures to rule out operator error. This may involve repeating the analysis with the same or a different method, etc. But, more importantly, we always perform a very thorough investigation of the submitted test sample by confirming that we have all the necessary information on our Sample Submission Form so that we can appropriately prepare the reference samples in the same or similar way to that used when the test sample was prepared. If this information was not available or was inaccurate, the samples are more likely to fail.
While the average FDA auditor is not generally trained in either Botany or Phytochemistry, they are skilled at finding loose threads. We have had several clients who chose not to invest in custom testing for custom products receive 483 notices from FDA.
Because there are many reasons a sample can fail and in order for the testing lab to be confident in their results, it is essential that the Sample Submission Form be filled out accurately, so we compare the right sample and plant parts to the test sample.
If you are using a contract manufacturer, the good ones have in-house labs and should be able to provide you with methodology to prove each and every claim on that label. If it costs more, remind yourself that the extra investment is a trifle compared to the legal bills a 483 would require.
Novel ingredients require special attention. Sometimes, the test sample was extracted in a very unique way that has removed unwanted phytochemical constituents, leaving typically only one component of interest that is not unique to the plant from which it was said to be derived. We have to fail the sample as not being chromatographically equivalent to the reference
QUALITY CONTROL CORNER
samples it was compared to. This is why it’s so important that suppliers of novel ingredients work with testing labs so they understand how the ingredients were processed and how they need to test it. It saves a lot of time, money, uncertainty and sleepless nights for all parties involved if suppliers of such novel ingredients interact with testing labs so they know how to test those ingredients. Another obvious cause for failure is the test sample is simply not what it is supposed to be, or even not the same genus and species as the reference samples compared with. Since ingredient suppliers and/or manufacturers do not have to prove by third party testing that they sell what they say they sell, the buyer must perform testing to document identity.
Identifying a Competent Lab How do you know if you are working with a lab that knows their stuff? One way is credentials. An important lab certifying organization is the International Organization for Standardization (ISO) accreditation which offers a variety of
certifications. 9001 is the most recognized certification as it applies to many industries. Just about every large manufacturer of just about any product is ISO 9001 or some variation thereof certified. The most meaningful accreditation to the dietary supplement industry is ISO 17025 which addresses how you manage a quality system, and confirms compliance with the AOAC Guidelines for Laboratories Performing Microbiological and Chemical Analyses of Food and Pharmaceuticals. It’s important not to simply accept an ISO but to ask, “What is the scope of the accreditation?” It is possible for a lab to be ISO 17025 and not reveal what specifically they are accredited for, so it’s important not to assume across the board applicability. Perhaps it’s for a narrow scope like pH testing only, which may not be relevant to your needs. Ask what a company’s ISO 17025 testing covers, specifically. Who certifies the certifiers? Any good accreditation body will be frequently under review by the International Laboratory Accreditation Cooperation (ILAC) Mutual Recognition Arrangement (MRA), International Accreditation Forum (IAF) and the Multilateral
Recognition Arrangement (MLA). Alkemist Lab’s ISO accreditation is with A2LA. Without such, global acceptance of your ISO accreditation may be in question. Not all accrediting bodies are created the same. There are many to choose from, but the ones that offer the strictest of audits and requirements are the Laboratory Accreditation Bureau, ACLASS and Perry Johnson Laboratory Accreditation Inc. A final note on what you should expect from your testing lab. Unfortunately, most labs don't reveal the entire method used to arrive at the information on the C of A that the client receives or they charge extra to provide it. That information should be included in information the lab provides to you, because if the test isn’t duplicable by another competent testing expert using the same methods, you’re vulnerable. As the industry works to address the challenges that come with a maturing industry and global supply chain, a robust testing program can strengthen many of the attendant vulnerabilities. It’s my personal and professional mission to share information that helps that happen.
INGREDIENTSONLINE.COM • FALL 2017
PLAN SMARTER NOT HARDER Why Companies Should Be Proactively Leveraging Food Ingredient Reviews and Approvals in FSMA Food Safety Planning By Carrie A. Kennedy, PMP, RAC | Burdock Group, Orlando, Fla.
he U.S. is in its seventh year of the Age of Food Safety Modernization,1 and approaching the one year anniversary of the General Compliance Period for Preventive Controls for Human Food.2 The requirements of FSMA are quickly moving from the abstract to concrete implementation as the “Educate before and while we regulate” mantra3 continues to shape the U.S. Food and Drug Administration (FDA) and Industry collaboration. FDA mandated Preventive Controls Qualified Individual (PCQI) materials are now offered and training is in progress.4 It finally appears that programs and resources needed to ensure the success of FSMA are growing to meet the needs of Industry. Unfortunately, in the flurry of activity to communicate “What’s new in FSMA,”5 the communication regarding what has stayed the same in the world of food safety has failed to make headlines or textbooks. The requirements of the Food Additive Petition (FAP) or Generally Recognized as Safe (GRAS) Conclusion have successfully required the analysis of hazards, application of validated controls, monitoring of the controls and corrective action6 for decades; as of 2015, FSMA now follows suit.7 The food manufacturers’ preventive controls inspections and audits of the near future will tell whether this lack of discussion on the relationship between safety considerations made in the months and years prior to a food product release (FAPs and GRAS Conclusions) and the food safety considerations made in the 90-days or more post-manufacture (Food Safety Plans) will cause companies
to: unintentionally render their products adulterated, waste company and government time and resources, and ultimately jeopardize the opportunity for manufacturers to demonstrate voluntary, competent and transparent compliance to FDA. The good news is that it’s not too late to leverage the work of the regulators and scientists seeking to ensure the safety of the nation’s food supply - the key is for Industry to remember that FSMA’s Food Safety Plan starts with FAP and GRAS.
The Contents of Food Safety Plans are Not New One of the FSMA mainstays, the Food Safety Plan, is strikingly similar to the documentation requirements for a Food Additive Petition (FAP) or a Generally Recognized as Safe (GRAS) Conclusion dossier, which is shocking to many as both methods of food ingredient approval originated more than 50 years prior to FSMA. The surprise comes to those who believe that the arrival of FSMA brings with it entirely novel methods for ensuring food safety. In fact, most of the methods are not novel at all, the FDA Center for Food Safety and Applied Nutrition (CFSAN) and Industry have a long history of conducting safety assessments and risk assessments for chemicals.6 As shown in the comparison to the requirements of FSMA in Table 1, the risk-based analysis regulatory requirements of the FAP and GRAS Conclusion are nearly analogous in application, with only a few notable differences in the process-centric versus the ingredient-centric focus, the formal recall plan and the PCQI standards of the FSMA Food Safety Plan.
Table 1. Comparisons of the Food Safety Plan requirements and aspects of the Food Additive Petition and Generally Recognized as Safe Conclusion requirements Food Safety Plan7
Food Additive Petition (FAP)8
Generally Recognized as Safe Conclusion (GRAS)9
Food Safety Modernization Act (2011)
Food Additives Amendment (1958)
Food Additives Amendment (1958)
May be reviewed/requested in an FDA Audit in written form
Requires hazard analysis (biological, chemical, physical)
Requires consideration of the resultant product’s intended use and intended consumers
Requires consideration of the resultant product’s characteristics, storage and distribution
Includes risk-based controls/limits
Requires monitoring of controls/limits
Requires supply-chain program monitoring
Requires a recall plan
Considers Environmental Impact
Requires procedures for corrective action
Requires validation of control effectiveness
Requires verification of consistent implementation of controls
Requires mandatory re-analysis and revalidation
PCQI staff oversight required
Characteristic of Requirement Federal Legislation Establishing Authority and Requirement Process- or Ingredient-based evaluation Type of decision-making process
*Re-analysis required at least every 3 years, but as needed with any: 1) significant change in product or process, 2) unanticipated problem, 3) ineffective control, 4) new information available about potential hazards.4 **A Petition/dossier amendment/update should be filed if any significant change in manufacturing, specifications or technologies occurs.10
INGREDIENTSONLINE.COM • FALL 2017
Adulterated at the Start? The risk-based analysis approaches for food additives and ingredients are critical and potentially time-saving foundations for the FSMA Food Safety Plan. Food ingredients are presented as one of the three primary sources of contamination in the PCQI training text.4 However, the text only mentions unapproved food and color additives (commonly categorized as “adulterants”— the presence of which causes the associated food to be “adulterated,”11 unsalable and/or subject to recall or seizure12). The subtle implication of the term “unapproved” is that the participant should understand that two compliance processes for ingredients exist (if the ingredient is not already subject to “prior sanction”). Any ingredient used in a food (and thereby listed as an ingredient in the “Hazard Analysis” documentation of a Food Safety Plan) must have evidence that it is an approved food additive, a GRAS substance or a prior sanctioned substance.13 In fact, if: 1) the PCQI fails to reference the available documentation regarding a food or ingredient that was approved through an FAP or GRAS or, 2) if the information contained within the FAP or GRAS is in conflict with the Food Safety Plan or its documented and monitored associated preventative controls (whether established by the PCQI’s company or not), the resultant food may be considered adulterated and a warning letter may be issued or a mandatory recall may be initiated by the FDA.12 For this reason, the inclusion of FAP and GRAS documentation is integral to any comprehensive Food Safety Plan.
Planning Smarter, Not Harder Omission of pre-market safety analysis information (embodied in a FAP or GRAS) from the Food Safety Plan dismisses a wealth of communications and decisions from FDA regulators and food safety subject matter experts regarding the safe conditions of manufacture and use for the more than
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10,000 known additives in food.14 In reviewing the most recent personnel hour investment estimates presented by FDA in their impact analysis for the 2016 Final GRAS Rule (approximately 170-190 personnel hours per notification15), the scope of time invested in pre-market risk-based analysis from a food company’s staff becomes clear. Further complicating matters, those sunk costs in personnel hours could potentially be required again in the FSMA Food Safety Plan Hazard Analysis steps if the pre-market safety analysis information goes unused. Personnel hours aren’t all that’s at stake, however; according to an industry expert, recalls can cost companies upwards of hundreds of thousands of dollars,16 but damage to the brand is inestimable. Potential lost time and resources could become a significant issue if the FAP or GRAS documentation and Food Safety Plans are not consistent and could require new or amended regulatory filings (FAP or GRAS) for the ingredients. New or amended regulatory filings have the possibility of pushing products and companies from the finish line back to the starting block.
Food Safety Planning Pre-Market Through Post-Production With future Food Safety Plans grounded in the FAP and GRAS documentation from pre-market to post-production, food companies and their PCQI staff can protect their products from unintentional adulteration and repetitive regulatory filings, minimize lost labor and resources and prevent enforcement actions from FDA. Voluntary, proactive and transparent communications of the risk-based analysis records for a food will make the most of the opportunity afforded by FDA in this transition period, hopefully contributing further to the recent increases in public trust in food safety because of FSMA.17 REFERENCES: visit www.ingredientsonline.com/blog/plan-smarter
For over 25 years, Burdock Group has been the experts in fusing science and compliance. Our services provide you peace of mind that your products are safe a compliant. • GRAS (Generally Recognized As Safe) • NDIN (New Dietary Ingredient Notification) • FAP (Food Additive Petition) • Risk and Regulatory Assessment • Claim Substantiation • Label Reviews Are you attending SupplySide West? Call or email us today to schedule a complimentary consultation at our booth L125! 407.802.1400 | ww.burdockgroup.com
MARKET TRENDS By Tony Xue | General Manager, ingredientsonline.com Shanghai, China
The harvest in Africa has been stable for the past two years and it’s expected to stay the same for this year with no big changes in price and supply.
There are three starting materials for Choline Bitartrate: Trimethylamine, Ethylene Oxide and Tartric Acid. Tartic Acid prices are on the rise by RMB 1000/mt, while the Ethylene Oxide price is on a decrease by RMB 800/mt and Trimethylalamine is stable. In order to keep the price stable and firm, the factories are limiting the output.
This product’s output is highly affected by the weather. Due to the hot summer looming, the haze is much less, so the pressure to deal with environment control is less. The major factories’ production are back to normal and they are trying to fulfill orders that were left behind from earlier. The supply is tight but the price should be stable now.
The U.S. Department of Commerce is initiating antidumping and countervailing duty investigations of imports of Citric Acid and certain citrate salts from Thailand, Belgium and Colombia. In order to prevent possible tracing and duty claims, Indian manufacturers are controlling the output. This leads to a tight supply of Citric Acid and its salts, and a slight price increase.
Due to raw material and labor cost increases, Gamma Oryzanol prices have increased a little bit. Market demand is on the rise and has good future prospects due to increased awareness of its health benefits.
ACESULFAME K FCC Acesulfame K price increased slightly due to the sharp increase of sucralose in 2016 but now it's very stable. If there is no big change on the factory side, it is predicted the supply will be very stable for the rest of the year.
ASCORBIC ACID SERIES Ascorbic Acid prices kept increasing in the first half of 2017 and now tend to be stable but firm. The traditional major manufacturers are still claiming the shortage is affected by shut-downs in the summer for maintenance. However, as of our last update, we have witnessed new factories such as Tuoyang, Lvyuan and Tiger provide good availability to the market. We predict that the supply will become balanced in the next one to two quarters.
BETAINE There are three starting materials for Betaine: Trimethylamine, Chloroacetic Acid and Sodium Carbonate. Trimehtylalmine is stable and Chloroacetic acid is on a rise by RMB 1000/mt which leads to a slight increase for the Betaine price.
CARNITINES The major factories of Carnitine including NEPGF, Hengtai and Koncep, are all shut down due to environment control. The other factory, Chengda in the Zhejiang Province, resumes production in July, but as was with D3, the governmental environment protection team is inspecting this area which may further affect the production. All the factories have many back orders and new shipment delivery could only be in September.
INGREDIENTSONLINE.COM • FALL 2017
CURCUMIN 95% EXTRACT The supply is stable now, although some reports advise that the harvest in India this year is not as good as last and most factories already have enough starting material from different channels.
D-CALCIUM PANTOTHENATE Vb5 is experiencing a sharp increase as of now. On one side, factories are shutting down production for maintenance, and on the other, the two major factories have stopped quoting and are not likely to resume in the short term.
DHEA Currently, DHEA is made from two sources: 4-Androstenediol from Soy and Wild Yam. The one from Soy is on a down trend because of the sufficient soy supply. Some factories are trying to add fermentation into this process flow to make the cost better. The one from Wild Yam is on a rise because of environment control.
GLUCOSAMINE 1. Current market: Due to environment control, small to medium sized factories are being shut down one by one. The production cost has decreased a little bit while the major factories enlarge the output a little bit. 2. Price Status: Its starting material’s (shrimp and crab shell) supply has been stable for the past two years and harvest is good. Only a few major factories have stayed in the market with good investment and are set up for environment control. The market and supply are expected to be stable for the rest of the year.
GLYCINE USP The price of Glycine is on a slight rise currently. One of the major factories in China is forced to hold production due to environment control. The buyers in China are trying to get more supply from countries close by, such as Cambodia.
GRAPE SEED EXTRACT Overall, the price is stable, but there are some changes that factories are focusing on while supplying the high quality extract with high
MARKET TRENDS JINAN JIUAN ESTER CHEMICAL CO., LTD
quality grape seed. This change comes from more and more customers paying attention to the ID and assay testing to make sure the material is coming from good sources.
HORNY GOAT WEED Due to the starting material plant experiencing a shortage, Horny Goat Weed has been in tight supply since early in the year. Now, the new harvest has just been completed and the price may come down step by step.
INOSITOL Currently, Inositol price is still at an historical level and the market demand is a little more than that of last year. Meantime, the supply is still stable.
LEADING SUPPLIER OF HIGH QUALITY CHOLINE, BETAINE, DMAE BITARTRATE AND PYRUVATE PRODUCTS
INULIN Price trends are stable, and manufacturers have good capacity to meet demand. Recent sales have increased.
L-ARGININE HCL & L-ARGININE BASE The price of Arginine was soft at the end of June but now is bouncing back. The hydrolyzed Arginine has issues of yellow spots this year, while the factory of fermented Arginine is trying to restructure the sales channel by direct selling to overseas end users while limiting the supply to the traders. We think the fermentation grade will play a more important role in the future market due to the strength of giant producers. In the summer time, the output rate is greatly affected by the temperature in the fermentation process and the factory advises us that the price may increase in the following two months.
L-CITRULLINE, L-CITRULLINE DL-MALATE 1:1 & L-CITRULLINE DL-MALATE 2:1
Betaine Anhydrous Betaine Citrate
Choline Dihydrogen Citrate
DMAE Bitartrate (L&DL)
Choline Bitartrate (L&DL)
Pyruvic Acid Sodium Pyruvate
After the CPHI trade show in June, the price has been at a high level and has also become a little soft in July. The reasons are: 1. Arginine price is better in June and the factories are getting a good supply to produce Citrulline. 2. More factories are trying to produce Citrulline and enlarge the production capacity. But now Arginine prices are bouncing back a little bit and the price of Citrulline and its salts will stay stable or increase slightly in the following two to three months.
L-CYSTEINE, L-CYSTEINE BASE & L-CYSTEINE HCI MONO / ANHYDROUS & N-ACETYL-L-CYSTEINE So far, L-Cysteine prices have been increasing for about eight months and are still in tight supply. The Hydrolyzed Cysteine supply is not stable at all while the fermentation grade output is still very limited. The summer’s hot weather will make the production even worse and the price is expected to rise.
L-LEUCINE REGULAR & L-ISOLEUCINE USP The price is stable for L-Leucine and Isoleucine as well as BCAA. The price of BCAA has been at a high level for some time, so even if the individual amino acid might be increasing, the price of BCAA itself is expected to be stable. Supply is tight during summer time and factories are fulfilling back orders step by step.
L-LYSINE MONO HCI GRANULAR The price of Lysine is on a down trend now due to industry change. In 2017, China’s government is implementing new regulations to better control the feed industry’s influence on the environment. Small to medium sized farms are being shut down while the production is centralized to large scale facilities with better control. This move leads to less consumption of corn and feed additives and Lysine being oversupplied now. Imported corn is further affecting the domestic price, and it makes the Glucose price experience a down trend as well. If the press of environment control is on-going as of now, and it is close to the
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harvest season of corn, the price is unlikely to increase and will stay stable or soft for the rest of the year.
L-TYROSINE & N-ACETYL-LTYROSINE As was with Cystein, Tyrosine supply is very short and tight, including its derivatives N-acetyl L-Tyrosine. Their prices are expected to be higher in the next two months.
L-VALINE Valine price has been on the rise for the past two months. Although Meihua and Fufeng produced some inventory in June and July, it seems the demand is still very strong. The summer time output will be limited due to the hot weather, and we think the price will keep firm and increase a little bit in the next two months.
MELATONIN Due to environment control, output in 2017 is very limited, so the demand is staying strong. Currently, the situation is a little better but supply is still tight.
well. There are only two major factories left, while other factories have walked away from production due to unpredictable starting material changes. The starting material DMSO factory needs to fix some technical issues, so currently the production is on and off periodically.
NIACIN (B3) & NIACINAMIDE (B3) USP Current supply is stable, although factories are facing challenges from environment control. At CPHI in June, we learned that most factories such as Lonza, Brother and Vanetta all increased quotes due to peak season coming from July to Oct.
PEA PROTEIN Due to the Jiaodong Peninsula drought in June, the whole area of Yantai (a city in Shandong province) is lacking water. The drought also has led to a shortage of manufacturing water from underground which greatly impacts production. Due to this inadequate output, the price of Pea Protein has started going up. The factory is still trying to resolve the issue and is expected to see improvement in September. If production can resume, the price should return to normal.
Due to its starting material, DMSO, experiencing a price increase, MSM price is on the rise as
L-Carnitine Base L-Carnitine Tartrate L-Carnitine Fumarate Acetyl-L-Carnitine HCL L-Carnitine HCL L-Carnitine Orotate Propionyl-L-Carnitine HCL L-Carnitine 50% Feed Grade
Levocarnitine Pharma Grade (US FDA approved) L-Carnitine HCL (JP-PMDA approved) Dl-Carnitine HCL Dl-Carnitine Orotate Raspberry Ketone Anhydrous Sarcosine
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PHENIBUT HCL Phenibut HCL is currently stable. The starting material is in stable supply and the factory is dealing well with the environment control pressure.
RIBOFLAVIN & RIBOFLAVIN 5 SODIUM PHOSPHATE B2 and its derivatives are stable in price and supply at this time.
SORBITOL POWDER This is one of the regular food additives which China exports large quantities to the U.S. Currently, the supply and demand are stable.
STEVIA 1. Current market: This natural sweetener is mainly used in drinks, snacks and dietary supplements. The export quantity is on a rise consistently with 3100mt in 2014, 3700mt in 2015 and 4400mt in 2016. The export quantity in the first half of 2017 has increased by 10% against the first half of 2016. 2. Price status: Generally stable since February of 2017 while refined sugar products are on a decrease possibly due to the fierce competition.
3. Starting material and pressure of environment control: We are currently in the period of waiting for the new harvest. While the starting material stock is used up, the price may increase. The cost for water treatment has increased greatly due to its large usage of pure water during the production process, but the major factories have taken measures and actions to make sure production runs well.
4. Future trend: The export quantity will keep increasing and usage will become popular.
TURMERIC & CURCUMIN EXTRACT ROOT
SUCRALOSE The price of Sucralose had been dropping since March and now appears to be stable at the level before it increased back in 2016. The major factories will put the price and output under control and we think the price will keep stable at Q3.
The latest news in July from Indian factories is they are experiencing heavy rain in the planting area of Turmeric. We also received the same feedback from Chinese factories almost at the same time. As of now, we see supply is a little tight and factories are busy with fulfilling orders. It is expected that the supply will stay tight and prices will stay firm or go even higher for the remainder of the year.
VITAMIN B1 & VITAMIN B6
Taurine’s price has been on the rise since earlier in the year. Due to the continuous investment of treating pollution and the starting material cost increase — including liquid nitrogen, liquid alkaline and coal — the price will remain at a high level in 2017. The major factories — including Jiangsu Yuanyang, Jiangyin Huachang, Fuchi and Qianjiang Yongan — are all trying to fulfill on-hand P.O.s from the past and are very behind.
Due to environment control, output is far behind. Domestic production is greatly impacted and supply is very tight. The price is on a rise in Q3 and will stay firm.
tight supply, got some inventory and are holding it, which leads to the price jump. Production is mainly done in the Zhejiang Province in China, including NHU, ZMC, Zhejiang Garden and others. The governmental environment protection team is now inspecting this area which leads to further shutdown. The other major factory, Kingdoway, also has stopped production. This situation will last at least three months.
There are signs that prices may be on the rise. The price was stable in the last three months, but some factories are controlling the output and now supply is becoming a little tight. Factories advise that production will be back to normal and output will meet demand but the market needs to be watched closely.
VITAMIN K1 OIL K1 Oil is in tight supply. The major two factories, Anhui Wanhe Pharmceutical Co., Ltd and Shandong Guangtongbao Pharmcetuticals Co., Ltd, are controlling the export quantity/quota which leads to shortage. Vitamin K1 1% Powder price is also affected, but a little better than the oil form.
XYLITOL Currently, the major factories are trying to resolve the shortage issue. Some factories are using tree wood fiber to produce D-Xylose, while it is usually produced from corn cob, and some are trying to expand production. The tight supply will still continue in Q3 but may get better in Q4.
Disclaimer: The forecast information is speculation and opinion only. ingredientsonline.com is providing this as a complimentary service and is not responsible for the information contained in this document.
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Greentech Biochemicals Co., Ltd. is a sales company on behalf of our cooperated manufacturers, especially for the products of Chondroitin Sulfate, Beta-Glucan and Keratin. The â€œGreentechâ€? brand has a good reputation all over the world based on our 19 years experience plus NSF and cGMP quality control system. We also can supply HALAL, ISO, DMF and EDQM supported documents as required. We are confident that you will discover Greentech Biochemicals Co., Ltd. is a perfect and valued supplier once you choose our products.
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Joe DaSilva, Vice President of Garmon Industries/NaturVet, discusses the ingredientsonline.com platform with Peggy Jackson, VP of Sales & Marketing at ingredientsonline.com. Included in the discussion are NASC approved ingredients.
Watch the full testimonial at www.ingredientsonline.com/testimonial
NEW FOURTH GENERATION of Dietary Supplement Ingredient
XinDu Bio-Tech, LLC produces a line of fourth generation wholefood supplements derived from proprietary extracts of the Hericium Erinaceus mushroom, commonly known as Lion’s Mane. Lion’s Mane is the most popular medicinal mushroom in traditional Chinese medicine due to its complete nutritional makeup and bio-activity. Its unique physiological properties make it a perfect host for bidirectional transformation.
research, development and clinical application. This process infuses a myriad of powerful bioactive ingredients into a singular whole-food source by controlling its growing medium. The science behind the process is unparalleled and the results are spectacular.
These products represent a quantum leap forward in nutrition, replacing the need of mix-and match multiple products through BioTransformational TechnologyTM.
XinDu products deliver a wide array of fully bioavailable vitamins, systematic enzymes, essential glycomes, specialized proteins, fatty acids - plus a newly identiﬁed Biological Response Modifier (BRM) that intelligently supports your body’s major systems and functions.
Bio-Transformational TechnologyTM is the result of over 34 years and millions of dollars of scientiﬁc
All products deliver at least 38 organic healthpromoting bio-active factors and co-factors that are blended and balanced naturally. They work synergistically at the cellular level to support your entire body. Each product is fortiﬁed with proven chinese herbs to focus on speciﬁc challenges with measurable impact.
Joe Lexue | Phone: 501-336-0077 | Email: firstname.lastname@example.org
We employ no synthetic ingredients. The organic components are naturally concentrated from a single-source whole-food that is produced intentionally to be readily bio-available to your body. XinDu products are based on positively impacting the meridian system. The meridian system is a concept in traditional Chinese medicine pertaining to the path through which the lifeenergy known as ”qi” ﬂows. There are 12 principle meridians which are divided into Yin and Yang groups. Each meridian coresponds to a speciﬁc organ. Each XinDu product is designed to positively impact speciﬁc meridians, increasing qi or “life force" in the body. We accomplish this by adding speciﬁcally chosen herbal extracts into the functional substrate of the growing medium.
SHOP NOW at xindu.ingredientsonline.com
Who’s your PCQI?
An Introduction to Preventive Controls Qualified Individuals By Loren Israelsen | President, United Natural Products Alliance If I were to ask, “Who is your PCQI?” (Preventive Controls Qualified Individual), there would be three typical responses: 1. What is PCQI? 2. I don’t know; I’ll ask around and get back to you. 3. Yes, we do have a PCQI (BTW: PCQI is a person, not a thing!). If an FDA investigator or a major customer were to ask this question of you or your staff, then what? I confess, it took me a while to get the acronym and the concept of PCQI straight in my head, so if that is your situation, you are not alone.
What’s a PCQI? So, what (remember, it is a “who”) is PCQI? Preventive Controls for Human Foods is one of seven provisions of the Food Safety Modernization Act (FSMA); the most sweeping reform of our food safety laws in more than 70 years, which was signed into law by President Obama on Jan.- 4, 2011. According to the Food and Drug Administration (FDA), FSMA aims to “ensure the U.S. food supply is safe by shifting the focus from responding to contamination to preventing it.”
This is how it works: 1.
Companies designate an individual(s) responsible for the preventive control food safety plan and its implementation.
A PCQI is required to have successfully completed training in the development and application of risk-based preventive controls at least equivalent to that received under a standardized curriculum recognized as adequate by the FDA or as otherwise qualified.
The standardized, curriculum-based course is two and a half days with active student participation.
Within the Preventive Controls for Human Food rule, a PCQI is required for all companies that manufacture foods and dietary supplements, outside of a couple of specific exemptions.
Class size is capped at 12 people per instructor. The coursework is standardized and approved by an independent body, the Food Safety Preventive Controls Alliance (FSPCA); a non-profit organization recognized by the FDA to oversee PCQI training.
After the Melamine protein disaster of 2008, and serious food safety problems with peanut butter, tomatoes, lettuce, cantaloupe, flour with E.Coli, sprouts, spinach and ice cream, both the public and Congress wanted change. That change was FSMA, and FSMA is based on HACCP.
PCQI graduates receive a certificate of training, which is specific to the PCQI, not the company. Thus, if your PCQI leaves your company or is on leave for any reason, you need to designate and train another PCQI.
The PCQI is responsible to create, implement and maintain compliance through the food safety plan that begins with PCQI training.
Each facility (not company) must have at least one PCQI.
A food safety plan is specific to each product type, and it is not uncommon for one facility to have multiple food safety plans.
The compliance date for PCQI implementation is dependent on the company size, and large companies were required to have a PCQI on staff as of September of last year.
FSMA is also the key to a new generation of food good manufacturing practices (GMPs) based on the Hazard Analysis Critical Control Point (HACCP) principles of “anticipate, prevent and validate.” The old system was “problem, investigate, fix and then repeat.”
The origins of HACCP go back to World War II as a solution to a big problem: defective artillery-shell firing pins that were blowing up our own soldiers or just not exploding. This problem was solved by carefully examining each possible failure (also known as the “critical point”) and fixing it until system integrity was confirmed. NASA adopted HACCP to make sure astronauts’ food in space was absolutely safe. Salmonella in a space suit = “Houston, we have a problem.” The Preventive Controls (PC) is the process, and the PCQI is the person or persons trained to devise, implement and execute the preventive controls developed through a food safety plan.
Who needs to have a PCQI? Who or what falls under the PCQI requirement? All food and supplement products, wherever they are from, that are consumed in the United States. Some companies are exempt including those that manufacture or sell seafood, juice, low-acid canned food, and Code of Federal Regulations Title 21 Part 111-compliant dietary supplements.
Here is our advice: If you produce, transport, distribute, warehouse or sell any products that require a Nutrition Facts or Supplement Facts label, you are strongly advised to complete PCQI training.
INGREDIENTSONLINE.COM • FALL 2017
• Large companies (>500 employees): September 2016 • Small companies (<500 employees): September 2017 • Very small companies (<$1 million in annual sales, but this includes the value of your inventory): September 2018 In the near future, if not already, customers will be asking about your PCQI status—and so will FDA during your next facilities inspection.
UNPA offers PCQI trainings Clearly, thousands of conventional food and dietary supplement/dietary ingredient companies require training to be in compliance with these federal regulations—a huge task. In response, the United Natural Products Alliance (UNPA) is offering PCQI trainings throughout the remainder of 2017 and into 2018 in several locations.
UNPA has set FSMA compliance as a high priority. We are doing all we can to provide the tools, training and resources for industry companies to be FSMA compliant. Our goal is to have a 100-percent FSMA-compliant membership within the next 12 months. We hope we can help you become FSMA compliant too.
About Loren Israelsen
About the UNPA PCQI trainings: • UNPA’s Larisa Pavlick, our VP of Global Regulatory & Compliance, is a lead instructor for FSPCA Preventive Controls for Human Food and can train your staff to be a PCQI. • We have contracted with other highly qualified PCQI trainers to work with us to increase class size as needed and as venue size allows. • The courses include food/dietary supplement/dietary ingredient case studies, which are an integral part of the training. • All coursework materials are included. You may learn more about PCQI and the trainings at the UNPA website: www.unpa.com. There are other parts of FSMA that require a qualified individual with separate training, such as the Foreign Supplier Verification Program (FSVP). We will be offering FSVP training in the future as well.
Loren Israelsen has been deeply involved in the commercial, political and regulatory issues facing the global dietary supplement industry since 1980. On the commercial side, he served as general counsel and president of Nature’s Way Products, Inc. Much of his career has involved creating and supporting efforts to allow broad access to dietary supplements together with the systems to assure product quality, safety and benefit. He has authored more than 150 articles and/or book chapters, and has lectured in more than 30 countries on dietary supplement and functional food issues. Currently, his greatest areas of interest are the growing presence of synthetic biology in the natural products industry, personalized nutrition and the preservation of the cultural knowledge on which the natural products industry is founded.
GMP, PCQI and FSVP Training in 2017-2018 Are your supplement/ingredient facilities FSMA and GMP compliant? Throughout 2017-2018, the United Natural Products Alliance is providing in-depth training to help companies comply with various aspects of the Dietary Supplement Health and Education Act and the Food Safety Modernization Act, including GMP, PCQI and FSVP training.
Please visit www.unpa.com/events for more information and to register.
Shandong Jincheng Bio-pharmaceutical Co., Ltd is honored as a National High-New Technology Enterprise. Main products are manufactured by microbial fermentation technology and advanced biological extraction & purification technology.
MAIN PRODUCTS: • L-Glutathione Reduced • S-Adenosyl-L-Methionine (SAMe) • Ademetionine Disulfate Tosylate • Ademetionine 1,4-Butanedisulfonate • Pyrroloquinoline Quinine Disodium Salt (PQQ) • Yeast β-Glucan • α-Ketoglutaric Acid Series of Products
NEW PRODUCTS: • Astaxanthin • L-Alanine • L-Hydroxyproline • β-Carotene We hold GMP, Kosher and Halal certificates. Glutathione has DMF registration in Japan, Korea and India.
2017 SEPTEMBER TUESDAY
27-28 SHOP NOW at jincheng.ingredientsonline.com
Bio-Technology Co., Ltd
ingredientsonline.com RoadShow - Dallas, TX Date: Time: Location:
Sept. 12 9 a.m. - 11:30 a.m. (Breakfast starts at 9:00 a.m.) Hilton Dallas Lincoln Centre 5410 LBJ Freeway, Dallas, TX
IFT Supplier's Night – Longhorn Date: Sept. 14 Location: Embassy Suites, Dallas-Frisco Convention Center, Frisco, TX
SupplySide West Date: Booth: Location:
Sept. 27 - 28 KK142 Mandalay Bay Convention Center Las Vegas, NV
CRN Annual Conference Date: Oct. 18 - 21 Location: Dove Mountain, Marana, AZ
NOVEMBER Beta Glucan Isoflavones HPLC
Kudzu Root 40% Olive Leaf P.E. 10%/20%/40% Oleuropein Phenibut
Pine Bark Extract 95% (PROAN) Policosanol 99% min. (Octacosanol 60%) Pomegranate P.E. 50% Polyphenols Quercetin Dihydrate 98%
SHOP JIANHE PRODUCTS at www.ingredientsonline.com
INGREDIENTSONLINE.COM • FALL 2017
IFT Suppliers' Night – Chicago Date: Nov. 1 Booth: 768 Location: Chicago, IL
ingredientsonline.com RoadShow - Chicago, IL Date: Time: Location:
Nov. 2 9:00 a.m. - 11:30 a.m. (Breakfast starts at 9:00 a.m.) Hilton Rosemont Chicago O’Hare 5550 N. River Rd, Rosemont, IL
FI & HI – India Date: Nov. 9 - 11 Booth: C38 Location: Mumbai, India
FI- Europe Date: Nov. 28 – 30 Booth: 08.0S32 Location: Frankfurt, Germany
PHARMACEUTICAL CO., LTD.
Vitamin E 50% Powder Feed Grade DL-Alpha-Tocopherol Acetate
JANUARY............................................................ ingredientsonline.com RoadShow - Phoenix Date: TBD Location: Doubletree by Hilton, Phoenix/Tempe, AZ
IPPE – Atlanta
Date: Jan. 30 – Feb. 1 Booth: B7586 – Hall B Location: Georgia World Congress Center, Atlanta, GA
FEBRUARY........................................................ IFT Suppliers' Night – Seattle Date: TBD Location: Seattle, WA
IFT Supplier’s Night – Vancouver Date: TBD Location: Vancouver, BC Canada
IFT Supplier’s Night – Portland Date: TBD Location: Portland, OR
IFT Supplier’s Night – Orlando
Date: Feb. 22 Location: World Center Marriott, Orlando, FL
Jilin Beisha Pharmaceutical Co., Ltd. always
adheres to the aim of “Quality utmost,
Reputation based,” and has created
an outstanding enterprise management regulation and quality management system. This system includes advanced analytical laboratories, ISO9001 & ISO2200 certifications and the required FAMI-QS certification for feed additives. Jilin Beisha’s advantage is continuous technological innovation and excellent cost control, which provide the capability to focus on the aspects of animal health and nutrition, food additives, as well as the chemical and pharmaceutical industries. This focus allows Jilin Beisha the ability to deliver premium products and service to global customers.
SHOP Beisha NOW atproducts jincheng.ingredientsonline.com at www.ingredientsonline.com
ingredientsonline.com RoadShow – Florida Date: TBD Location: TBD
HUBEI HUNTIDE BIOTECH CO., LTD (Wuhan Jetide Biotech Co., Ltd)
MARCH............................................................... IFT Supplier's Night - Anaheim
Date: March 7 Location: Disneyland Hotel, Anaheim, CA
Date: March 9-11 Booth: 3481 Location: Anaheim Convention Center, Anaheim, CA
Food Ingredients China Date: March 22-24 Location: Shanghai, China
IFT Supplier's Night - Phoenix Date: TBD Location: Phoenix, AZ
APRIL.................................................................. IFT Supplier's Night - Bonneville
Date: TBD Location: South Towne Expo Center, Sandy, UT
ingredientsonline.com RoadShow - Salt Lake City Date: TBD Location: Hilton Salt Lake City Center, Salt Lake City, UT
IFT Supplier's Night – NYIFT
Date: TBD Location: Garden State Exhibition Center, Somerset, NJ
Date: April 10-11 Booth: # E116 Location: Meadowlands Convention Center, Secaucus, NJ
L-Carnosine N-Acetyl L-Carnosine Zinc Carnosine (Polaprezinc) L-Alanyl-L-Glutamine Glycyl-L-Glutamine Glycyl-L-Tyrosine VE TPGS Huntide was founded in 2012 and today stands as a leading manufacturer of nutraceutical and pharmaceutical ingredients, as well as ranks in the top largest small peptides manufacturers in China by focusing on R&D, manufacturing and commercialization of small peptides. Certifications: Kosher, ISO9001
SHOP Huntide Products at ingredientsonline.com INGREDIENTSONLINE.COM • FALL 2017
HUBEI GEDIAN HUMANWELL
2018 EVENT SCHEDULE MAY................................................................. National Animal Supplement Council (NASC) Date: May 1-3 Location: Scottsdale, AZ
IFT Supplier's Night – NCIFT - San Francisco Date: May 8 Location: Pleasanton, CA
VitaFoods – Switzerland
Date: May 15-17 Location: Palexpo, Geneva, Switzerland
United Natural Products Alliance (UNPA) Date: TBD Location: Salt Lake City, UT
JUNE............................................................... ingredientsonline.com RoadShow - Southern California
Leading the way in factory-direct DHEA.
Date: TBD Location: Fairfield Inn, Tustin, CA
Gedian Humanwell is a cGMP compliant manufacturer approved by the regulatory authorities of US-FDA and CFDA. EIR letter and Kosher Certificate available.
Date: June 26-28 Location: Shanghai, China
JULY................................................................ IFT Annual Conference
SHOP NOW at gedian.ingredientsonline.com
Date: July 15-18 Location: McCormick Place South, Chicago, IL
CENTRAL STAGE SPONSORSHIP ingredientsonline.com is pleased to be sponsoring Larisa Pavlick, UNPA's VP of Global Regulatory and Compliance, at SupplySide West! Hear Larisa's informative session — Understanding How FSMA & PCQI Impact Your Supply Chain — at the SupplySide Central Stage on Wednesday, Sept. 27, from 2:00-2:30 p.m. You will also have the opportunity to hear Sherry Wang, Founder and President of ingredientsonline.com, along with Peggy Jackson, VP Sales & Marketing, close the session with vital information on the importance of traceability and transparency in the supply chain. To learn more about ingredientsonline.com, the Global Sourcing Factory-Direct Marketplace, stop by Booth KK142.
Date: TBD Location: Rancho Palos Verdes, CA
SEPTEMBER................................................ IFT Supplier's Night – Longhorn
Date: TBD Location: Embassy Suites, Dallas-Frisco Convention Center, Frisco, TX
ingredientsonline.com RoadShow - Dallas DATE: TBD Location: Dallas, TX
OCTOBER...................................................... CRN Annual Conference Date: TBD Location: TBD
NOVEMBER................................................. SupplySide West
Date: Nov. 6-10 Location: Mandalay Bay Convention Center, Las Vegas, NV
FI & HI – India Date: TBD Location: TBD
IFT Suppliers Night – Chicago Date: Nov. 7 Location: Rosemont, IL
ingredientsonline.com RoadShow - Rosemont Date: TBD Location: Rosemont, IL
Date: Nov. 27-29 Location: Frankfurt, Germany 26
INGREDIENTSONLINE.COM • FALL 2017
Subject to change and visit our online calendar for the most up to date information. www.ingredientsonline.com/events-calendar.html
ANHUI TIGER BIOTECH CO., LTD, a BBFY factory, is opening a new Vitamin C manufacturing facility in Anhui, China.
Production will begin in Q4, 2017, and the annual production capacity will be 40,000 metric tons.
“Based on our 40,000mt annual output capacity, Anhui Tiger Biotech Co. Ltd. will become the largest Vitamin C factory in the world.” Mr. JieBin Xu, Sales Director for BBFY, stated,
Look for this new ingredient listing with ingredientsonline.com and real-time U.S. inventory in February 2018.
BBFY HUAIBEI SINOGEL
Amino Acid Co., Ltd.
L-Alanine, DL-Alanine and D-Aspartic acid with the most advanced scientific research, KOSHER, HALAL and ISO22000 certifications. Our biological engineering technology is friendlier to the environment than chemical synthesis production methods. We offer a competitive advantage with low production cost and high quality ingredients.
Shop Sinogel products at ingredientsonline.com
Sunshine Biotech is the
Tiger is identified as a
largest manufacturer of CITRIC ACID
Its salt products in Southeast Asia have a capacity of 80,000MTS. The raw materials is Cassava, non-GMO. Products include: • Citric Acid Anhydrous Fine Granular • Citric Acid Anhydrous Granular • Citric Acid Monohydrate
SHOP NOW at sunshine.ingredientsonline.com
by Anhui Science & Technique Products include: • L-Ascorbate-2-Phosphate • Vitamin C • Vitamin H and Vitamin E Our Vitamin C is produced with a two steps fermentation method in a GMP approved facility.
SHOP NOW at tiger.ingredientsonline.com
HIGH BIO-AVAILABLE CURCUMIN SERIES
High bio-available Curcumin series is now available from Ningbo Traditional Chinese Pharmaceutical Corporation (Ningbo Herb): Curcumin 95%, Water soluble & oil soluble curcumin , High Bio-Availability Curcuminoid (HBA Curcuminoids) and Turmeric powder. HBA Curcuminoids comes as a dry, freeflowing powder. Its ideal application is dry or powdery dietary supplement products. According to Ningbo Herb’s human bioavailability study, because of its hydrophobic molecules agglomerate, pure Curcumin has very poor uptake efficiency. Ningbo’s HBA Curcuminoids is 40 times more absorbable than pure Curcumin allowing it to enter the blood stream. HBA Curcumin Complexes are 100% natural Turmeric Root Extract with C14, DNA, TLC and HPLC third-party certificates.
Water soluble Curcumin Curcumin health drinks’ popularity is rising for benefits like joint health, liver health and antioxidant/ oxidative stress. Poor Curcumin water solubility and resulting sedimentation in beverages make it visually unappealing. Ningbo Herb developed a new formula for the Curcuminoids that’s soluble in water up to 200 mg/ml. The Curcuminoids are yellow matter extracted from Turmeric Root with C14, DNA, TLC, HPLC third-party certificate. It contains 3 peaks as below:
It contains 3 peaks as below:
Main Specification: 5-40% Total Curcuminoids, HPLC CAS No: 458-37-7 (Curcumin)
Main Specification: 1-10% Total Curcuminoids, HPLC
GOLDEN FACTORY MEMBERS Along with our growth in India and the U.S., we have also been expanding our Golden Factory Members. These factories bring you high quality ingredients and a commitment to superior standards. Each month we deliver email communications for you to learn the factory of origin on many popular ingredients with complete transparency. These members also attend our Global Sourcing Events and customer meetings to learn about your specific ingredient needs. This allows for one-on-one interactions and information exchanges. If you would like a visit from one of these Golden Factory Members, just send us an email – email@example.com.
INGREDIENTSONLINE.COM • FALL 2017
NEOHESPERIDINE DIHYDROCHALCONE (NHDC) Neohesperidine Dihydrochalcone (NHDC) is obtained by hydrogenation of Neohesperidin, which is extracted from the family of orange peel (orange peel, pomelo peel, citrus peel). It’s a bitterness suppressor and flavor modifier, which also gives a very intense sweet taste. According to Ningbo Herb, NHDC is 1500-1800 times sweeter than sucrose at threshold concentrations with recommendation dosage: 20~30 mg/ L, Flavour enhancer: 4~5 mg/ L and the organoleptic properties are different from sugar. NHDC -95% Min HPLC white crystalline powder has application in all sectors of the food industry and in beverages, sweets, canned vegetables, desserts, sauces, food supplements, etc. Additional applications are for the livestock industry, improving the palatability of feed and in personal care products like elixirs and toothpastes. [Molecular Formula]: C28H36O15
[Molecular Weight]: 612.58 [NHDC, CAS No.]: 20702-77-6 is authorized for human consumption, both as a sweetener and flavor modifier in all European Union countries (E-959), (EEC Directives 94/35/EC and 96/83/EC), United States (FEMA GRAS No 3811), Switzerland, Czech Republic, Australia, New Zealand and various countries in Africa, Latin America and the Middle East. These ingredients are available at http://www.ingredientsonline.com/catalogsearch/result/?attr=0&q=ningbo+herb
JIANGYIN HUACHANG Food Additive Co.,Ltd
2500 square meters factory ISO9001, ISO22000, Kosher and Halal certified Meets the sterile requirement of 100,000 levels GMP standard
Founded in 2007, Jiangyin Huachang Food Additive Co, Ltd is located in the center of the “Yangtze Delta Economical Zone.”
INGREDIENTSONLINE.COM • SHOP NOW at huachang.ingredientsonline.com
GLOBAL SOURCING EVENTS
FACTORY-DIRECT GLOBAL SOURCING EVENT
2017 ROADSHOW SERIES AND SEMINAR Join the conversation and attend this free event in a city near you!!!
This morning seminar includes continuing education as we bring you leading industry speakers to deliver updates on the unstable regulatory environment. In addition, learn about the factory-direct ingredientsonline.com e-commerce platform including quality control processes, market trends/intelligence directly from our teams in China, downloadable QC documentation and real-time U.S. inventory, all with complete transparency. We’ve combined education and networking, all packed into a simple and easy format in your backyard. Learn how to SAVE TIME AND SAVE MONEY – Register now, it’s FREE!!
Date: Thursday, Nov. 2, 2017 Time: 9:00 a.m. - 11:30 a.m. (Breakfast starts at 9:00 a.m.) Location: Hilton Rosemont Chicago O’Hare 5550 North River Road, Rosemont, IL
Please join us at our Global Sourcing Event in Dallas to hear our featured speaker, Scott Steinford, CEO of Trust Transparency Consulting. New FSMA regulations, current laws, litigation and consumer expectations are now defining transparency as an established norm and required policy. Scott will explain and focus on the why, when and how, so you know if you are operating at the new level of required/expected transparency. He will look at the current terrain of transparency and glimpse at its increasing future importance.
Date: Tuesday, Sept. 12, 2017 Time: 9 a.m. - 11:30 a.m. (Breakfast starts at 9:00 a.m.) Location: Hilton Dallas Lincoln Centre 5410 LBJ Freeway, Dallas, TX 75240
Check out the Events Calendar starting on page 24 for a list of 2018 Global Sourcing Events near you or visit http://www.ingredientsonline.com/events-calendar.html.
INGREDIENTSONLINE.COM • FALL 2017
THANK YOU Southern California
he Southern California ingredientsonline.com Factory-Direct Global Sourcing Event was a great success; thank you to all who participated.
Held in Tustin, Calif., this event brought together the dietary supplement, food & beverage, animal nutrition and personal care industries for a morning of education and networking at the local level. Participants observed firsthand how to save time and money by using the ingredientsonline.com factory-direct e-commerce platform offering complete transparency. Participants were extremely engaged with the presentation from Larisa Pavlick, our featured speaker. Larisa is the VP of Global Regulatory and Compliance with the UNPA and delivered outstanding information on the current regulatory environment including FSMA and PCQI.
The audience included R&D, QC, Purchasing and C-Level executives from companies such as Robinson Pharma, Garmon Corporation/Naturvet, Glanbia, Wellington Foods, Reeds, Alkemist and more. We also had factory partner Jinan Jiuan Ester Chemical Co. present information on their products and services. This is just one of the ways ingredientsonline.com provides complete transparency in supply-chain management; by bringing the factory to you at these educational events. Take advantage of the ingredientsonline.com Global Sourcing Events and the opportunity to stay current on FSMA and FSVP regulations. Hear from experts to gain insight on supply-chain management. Meet with the ingredientsonline.com team to learn about features and benefits of the e-commerce platform and how it will save you time and money with complete transparency.
For a list of upcoming RoadShow Series cities and dates see page 24 or visit - www.roadshow.ingredientsonline.com
We hope to see you in Dallas and Chicago!
INGREDIENTSONLINE.COM â€˘ FALL 2017
QUALITY CONTROL PROCESS
ere at ingredientsonline.com, ingredient quality and safety are always the number one concern. We partner with manufacturers from all over the world, which commands us to develop standard procedures to implement the requirements for the Foreign Supplier Verification Program (FSVP) rule under FSMA. Our highly skilled quality control teams conduct hazard analysis for imported foods, evaluate supplier’s performance and conduct foreign supplier verification activities such as audits, sampling, testing and reviewing supplier’s product safety records. We outsource accredited labs to verify the quality of products before shipment.
KNOW YOUR QUALITY FIVE STEP QA/QC PROCESS:
1. MANUFACTURER QUALIFICATION
3. PRE-SHIPMENT INSPECTION
On-site auditing and qualification
Quality inspection prior to overseas shipment and arrival in the U.S.
With ingredient suppliers located in various countries across the world, manufacturer qualification programs can be an extremely daunting task. Before we even bring a manufacturer onto our platform, they must undergo and pass a thorough inspection process to become "qualified." Our audit checklist reviews everything from site security to production procedures to testing verification and compliance certifications. We even audit their working environment and energy-saving methods. Audits and inspections are meticulously and regularly carried out for both new and existing manufacturers.
Our China-based Quality Control Unit inspects and releases shipments prior to allowing the containers to ship overseas. Once the products have arrived at our U.S. warehouses, our local warehouse and QC team performs a second inspection before finally entering the products into inventory.
2. IN-HOUSE LAB TESTING Purposeful testing program to verify proudct specifications We understand that above all else, the quality of the material and adherence to material specifications are imperative. That is why our in-house lab tests for mesh size, density, microbial contamination and indentification verification. In addition to our own testing, samples from new products and manufacturers are sent to accredited third party labs for additional quality verification. Before the product is even put on our shelves and sold on our website, we review the lab reports to ensure each product is of the highest quality.
4. MANUFACTURER CONSISTENCY Approved manufacturer origins and preferred manufacturer tracking We believe that consistent quality is as important as maintaining exceptional quality. Part of our quality control program includes keeping records of all approved manufacturer origins for our customers and tracking the preferred origins based on their requests. We implemented this process to help our customers with their compliance in cGMP.
5. CUSTOMIZED SHIPPING Recorded customized shipping instructions Your customized shipping is never compromised. We carefully record all shipping instructions stated on each purchase order such as documentations, lot number, shelf life and special labels, and we make sure each request is procured on time. Every ingredientsonline.com customer can trust that they will receive exactly what they ordered, how they ordered it... every order, every time.
TOLL FREE: (877) 550-3600 · WWW.INGREDIENTSONLINE.COM
SEE US AT SUPPLYSIDE WEST
ingredientsonline.com™ is an innovative online e-commerce platform providing nutritional raw materials for the Dietary Supplement, Food & Be...
Published on Oct 1, 2017
ingredientsonline.com™ is an innovative online e-commerce platform providing nutritional raw materials for the Dietary Supplement, Food & Be...