VOLUME 2 NO. 2
ingredientsonline.com, an innovative online e-commerce platform providing nutritional raw materials for the Dietary Supplement, Food & Beverage, Cosmetic and Animal Nutrition Industries.
We will be exhibiting at 10 events in Q2 and see the back cover for a complete list of Global Factory-Direct Sourcing events near you.
COMPLETE TRANSPARENCY FACTORY-DIRECT PRICING
FACTORY OF ORIGIN
Sign up at ingredientsonline.com to reveal the benefits of Complete Transparency
SPRINGTIME IS ALL ABOUT NEW GROWTH AND I’M HAPPY TO REPORT THAT INGREDIENTSONLINE.COM HAS BEEN GROWING STEADILY. We’ve more than doubled our sales revenue
in Jan. 2017 compared to Jan. 2016, so thank you for your business and continued support. In addition, ingredientsonline.com now offers over 750 ingredients from more than 180 global factories, providing you even more factory-direct options at very competitive prices.
CONTENTS President's Letter.....................................3 Technology & Transparency................ 4 Ingredients Listing................................ 6 Regulatory Perspective....................... 10 Market Trends........................................14 Testimonials...........................................19
We’ve also added an Innovative Ingredient section to the platform. Here you will find cutting edge ingredients with published clinical results. Our first ingredient listed is Lion’s Mane; be sure to check it out and check back often to take advantage of adding these new ingredients into your formulas. Our 2017 RoadShow/Seminar Series is off to a great start having completed both our Arizona and Florida events, see page 23 for details and back cover for a list of events in your area. At these events, we were able to spend quality time with our customers and prospects, and learn about their challenges. In Arizona, we introduced one of our factory-direct partners, CCGB, to the attendees. This type of connection allows for not only complete transparency but also inside intelligence on market conditions directly from the factory. We would like to be your number one resource, not only for sourcing, but to help solve those challenges such as shipping logistics and costs, manufacturing delays, easy access to QC documentation and more.
Quality Control Corner....................... 20 Events......................................Back Cover
PROUD MEMBERS OF THESE LEADING INDUSTRY ASSOCIATIONS!
One way to help with those challenges is to open new regional warehouses and stock frequently used ingredients. I’m happy to announce that we will soon be opening our Miami warehouse, and if you order before 2 p.m., your order will ship that same day. This is certain to solve some of your delivery challenges. I look forward to meeting you and learning about your challenges; let’s use our technology to find a solution.
American Herbal Products Association
Please see the back cover for a list of our 2017 events and I hope to meet you soon. National Association of Flavors and Food-Ingredient Systems
Sherry Wang Founder and President ingredientsonline.com
National Animal Supplement Council
United Natural Products Alliance
TECHNOLOGY & TRANSPARENCY IN SUPPLY CHAIN SOURCING Offering a continuous supply of consistent quality ingredients from approved global factories of origin.
INVENTORY PROTECTION PROGRAM Customers who provide their NO OBLIGATION 2017 projection can rest assured we will hold U.S. inventory for you (subject to our final approval, availability and confirmation). There’s absolutely NO RISK! Email: email@example.com
MARKET TRENDS On many popular ingredients, look for the arrow ↑↓ next to the price$/kg. This new feature speculates upcoming rising or decreasing prices. See the Market Trends article on page 14 for more details.
CATALOG New EZ sort tab in the navigation bar allows for quick ingredient search by alphabet, category, application and more.
SAVE TIME & SAVE MONEY SHOP NOW at INGREDIENTSONLINE.COM It's FREE!
Sign up at ingredientsonline.com to reveal the benefits of Complete Transparency
FACTORY OF ORIGIN
By partnering with factories and consolidating resources, we are able to cut out the middle man and reduce costs. Pricing on the website is transparent so that each customer knows the lowest cost for their products.
We believe that consistent quality is as important as maintaining exceptional quality. Part of our quality control program includes keeping records of all approved manufacturer origins for our customers and tracking the preferred origins based on their requests.
QA/QC DOCS Review all documents and certificates to ensure they meet our standards before going online for customers to download. All QC documents are on the right hand side of each ingredient page. Simply click and download your necessary docs.
U.S. INVENTORY That's why each ingredient page lists the real-time U.S. inventory in our CA or NJ warehouses.Plus, our new Miami warehouse will open soon, creating even more efficiencies for our customers in Florida. Watch for additional warehouses in Salt Lake City and Dallas to open in 2017.
FACTORY-DIRECT PRICING GLOBAL SOURCING CENTER
5 HTP 98% 5-Methyl-7-Methoxy Isoflavone 7-Methoxy Flavone
Broccoli Powder Butcher's Broom Extract 10:1
Acesulfame K FCC Acetyl L-Carnitine HCL Agmatine Sulfate Alfalfa Powder Aloe Vera P.E. 200:1 Alpha Cyclodextrin Alpha Keto Glutaric Acid Alpha Lipoic Acid Alpha Lipoic Acid R Versi Alpha Lipoic Acid Sodium Alpha Lipoic Acid Sodium R Version Apple Cider Vinegar Powder Apple Juice Powder ARA 10% CWS Food grade Ascorbic Acid 100 Mesh USP Ascorbic Acid Coated Feed Ascorbic Acid DC97 Cellulose Ascorbic Acid USP 40-80 Mesh Ascorbyl Palmitate Aspartame Astaxanthin 2.5% Beadlet Astaxanthin 5% Oil Astaxanthin Powder 2% Astragalus PE.50% Polysaccharid
Bacopa 20% by HPLC Barley Grass Powder Barley P.E. 10:1 BCAA Granule2:1:1 (Hydrolysis) BCAA Instant 2:1:1 BCAA Instant 2:1:1 (Vegan) BCAA Instant Grade 4:1:1 BCAA Regular Grade 2:1:1 Bearberry Leaf Extract 10:1 Benfotiamine Berberine HCL Beta carotene 1% Powder CWS Beta Carotene 20% Beadlet Beta Carotene 20% Powder Beta Carotene 30% Oil Suspensi Beta Carotene 96% -101% Powder Beta Cyclodextrin Beta Glucan (1, 3/1, 6) 70% Betaine 47% Liquid Betaine Anhydrous Betaine Anhydrous Feed Grade Betaine HCL 95% Feed grade Betaine HCL Food Grade Betaine HCL USP Bilberry Extract 25% Biotin (Vitamin H ) Biotin (Vitamin H) 1% Biotin (Vitamin H) 2% Bitter Melon Extract 10:1 Bitter Melon P.E.4:1 Black Currant Extract Black Currant Fruit Powder Black Mulberry Fruit Powder 1-2% AC Black Mulberry FruitPE 25% AC Black Rice Extract25% Anthocyanin Blueberry Fruit Powder Blueberry Juice Powder Boswellia Serrata P.E. 65% Bovine Collagen Powder (Type I)
VITAMIN C SHORTAGE?
Caffeine Anhydrous Synthetic Calcium Ascorbate Calcium Ascorbate DC97 Granular Calcium Beta Hydroxybutyrate Calcium Carbonate DC95 Calcium Carbonate Mineral Calcium Citrate DC97 Granular Calcium Citrate Powder USP Calcium HMB Monohydrate Calcium Orotate Calcium Pyruvate Chitosan 90-95% Chlorella (Broken Cell) Choline Chloride Choline Chloride 50% Silica Choline Chloride 60% Corn Cob Choline Chloride 75% Liquid Choline Dihydrogen Citrate Choline DL-Bitartrate Choline DL-Bitartrate Coated Choline L-Bitartrate Choline L-Bitartrate Coated Chondroitin Sulfate USP Chrysin Citicoline Sodium Citric Acid USP 30-100 Mesh CLA EE Softgel CLA FFA Oil 80% CLA FFA 40% Powder CLA FFA Softgel CLA TG 40% Powder CLA TG 60% Powder Coenzyme Q10 10% CWS Coenzyme Q10 20% CWS Coenzyme Q10 40% CWS Coenzyme Q10 USP Copper Citrate Copper Gluconate Cordyceps Sinensis P.E. 10:1 Cranberry Extract Cranberry Fruit Powder Cranberry P.E. 4:1 Creatine Anhydrous Creatine Citrate 1:1 Creatine Ethyl Ester HCL Creatine Gluconate Creatine HCL Powder Creatine Mono 200 Mesh Creatine Mono 80 Mesh Creatine Monohydrate Granular Creatine Monohydrate Instant Creatine Pyruvate Creatinol-O-Phosphate Creek Yellow Grass 10:1 Cuminum Cyminum 10:1 Curcuminoids 15% HPLC Cyanocobalamin 1% Cyanocobalamin USP Cymbidium Goeringii 10:1
D-Alpha Tocopherol 1000 Oil D-Alpha Tocopherol 1300 IU Oil D-Alpha Tocopherol 800IU Oil D-Alpha Tocopheryl Acetate 1000 IU D-Alpha Tocopheryl Acetate 1100 IU
D-Alpha Tocopheryl Succi 1185 IU D-Alpha Tocopheryl Succi 1210 IU Dandelion Pxtract 5:1 Dandelion Root P.E. 3:1 D-Aspartic Acid D-Calcium Pantothenate DCP Dihydrate Feed Grade DCP Dihydrate Granular DHA 10% CWS Food grade DHEA Micronized Powder DHEA Regular DHEA regular (Wild Yam Source) DiCalcium Phosphate Dihydrate DiCreatine Citrate 2:1 Diindolylmethane DL-Alanine DL-Malic Acid FCC DL-Methionine DL-Methionine(Feed Grade) DL-Phenylalanine DMAE DL- Bitartrate DMAE L- Bitartrate D-Mannose DMG HCL B15 D-Panthenol D-Pinitol D-Xylose
Echinacea Purpurea PE 4% Erythorbic Acid Erythritol Ethyl Maltol Ethyl Vanillin Evodiamine 98%
Ferrous Fumarate Ferrous Gluconate Dihydrate Ferrous Lactate Powder Flaxseed Oil Powder Folic Acid 97% Fructo Oligosaccharide Liquid Fructooligosaccharides 90% Powder Fructooligosaccharides 95% Powder Fucoidan 85% Fucoxanthin 10% UV Fumaric Acid
GABA Galactooligosaccharide 57% Powder Galactooligosaccharide 57% LIQ Galla Chinensis P.E.82% Gamma Oryzanol GanogenÂ® Mushroom Beta-Glucans Garcinia Cambogia P.E 60% Garcinia Cambogia P.E. 50% Garlic Extract 3:1 Ginger Extract 5% Gingerols Ginger Root Extract 1%WS Ginger Root Extract 6% Ginkgo Biloba Extract 24/6 Ginkgo Biloba Leaf Extract CP Ginkgo Biloba Leaf Extract20:1 Ginkgo BilobaleafextractUSP-NF Glucomannan 90% Glucomannan 95% Glucosamine HCL 80 Mesh
Glucosamine HCL 20 Mesh Glucosamine HCL 40 Mesh Glucosamine HCL DC Glucosamine Sulfate 2KCL DC Glucosamine Sulfate 2KCL40 Mesh Glucosamine Sulfate 2KCL80 Mesh Glucuronolactone Glycerine 95% Glycerol Monolaurate Glycerol Monostearate Glycine USP Grape Seed extract 95% (EUR) Green Coffee Bean P.E. 50% Green Tea 95% Polyphe 45% EGCG Green Tea 50% Polyphenol Green Tea 98% Polyphe 50% EGCG
Hawthorn Berry P.E. 5:1 Hawthorn Extract 25% High Fructose Syrup Holy Basil Powder Hordenine HCL Horny Goat Weed 10% Icariin Horny Goat Weed 20% Icariins Horny Goat (Epimedium) P.E 10% Horny Goat Weed 10% Icariin (Organic) Horny Goat Weed 20% Icariin (Organic) Huperzine A 1% HydroxyPropyl Methyl Cellulose
Indole-3-Carbinol Inosine Anhydrous Inositol DC95 Granular Inositol Hexaphosphate Powder Inositol NF/FCC Inositol Nicotinate Inulin Inulin (Organic) Isomalto-Oligosaccharides 90% Ivy P.E. 5:1
Japanese Thistle P.E. 5:1
Krill Oil Kudzu Root 40% Isoflavones HPLC
Lactic Acid Powder 60% Lactisole L-Alanine L-Arabinose L-Arginine L-Aspartate L-Arginine (Fermentation) L-Arginine (Regular) L-Arginine AKG 2:1 Dihydrate L-Arginine HCL Regular L-Arginine HCL (Fermentation) L-Ascorbate-2-Phosphate L-Aspartic Acid USP L-Calcium Lactate L-Carnitine Base L-Carnitine Fumarate L-Carnitine HCL L-Carnitine Tartrate L-Carnosine
The industry is facing a shortage of Vitamin C series ingredients like Ascorbic Acid USP, DC97, Calcium Ascorbate and Sodium Ascorbate. Due to our factory-direct relationships, we have these high-demand ingredients in stock and ready for immediate delivery. Login now to see current inventory levels and aggressive, factory-direct pricing!!! - www.ingredientsonline.com
L-Citrulline L-Citrulline DL-Malate 1:1 L-Citrulline DL-Malate 2:1 L-Cysteine HCl Monohydrate L-Cysteine (Vegan) L-Cysteine HCL Anhydrous AJI L-Cysteine HCL Anhydrous (Veg) L-Cysteine HCLMonohydrate (Veg) L-Cystine Lemon Balm Extract 4:1 Lemon Powder L-Glutamic Acid L-Glutamic Acid Hydrochloride L-Glutamine FCC L-Glutathione Reduced L-Histidine HCL Monohydrate L-Histidine Base L-Hydroxyproline Lion's Mane Mycelium Extract Liquorice Extract L-Isoleucine Granular L-Isoleucine Instant L-Isoleucine USP L-Leucine Fermentation L-Leucine Instant L-Leucine Regular L-Lysine Mono HCL Feed Grade L-Lysine Mono HCL Granular L-Methionine L-Norvaline Longjack P.E 100:1 Longjack P.E 200:1 L-Ornithine Mono HCL L-Phenylalanine L-Proline USP L-Pyroglutamic Acid L-Serine L-Theanine L-Threonine L-Threonine Powder Feed Grade L-Tryptophan Feed Grade L-Tryptophan Granular L-Tryptophan USP L-Tyrosine Luo Han Guo 10:1 Luo Han Guo 25% Mogrosides V Luo Han Guo 50% Mogrosides V Lutein 5% Powder Lutein 10% powder Lutein 10% Powder CWD Lutein 20% Oil Lutein 5% Beadlet L-Valine L-Valine Instant Lycopene 10% Powder Lycopene 20% Powder Lycopene 5% Powder Lycopene 5% Powder (Tomato)
MACA P.E. 4:1 Magnesium Ascorbyl Phosphate Magnesium Beta Hydroxybutyrate Magnesium Carbonate Heavy Magnesium Citrate Anhydrous Magnesium Citrate Granular Magnesium Citrate Powder Magnesium Gluconate Dihydrate Magnesium Lactate Powder Magnesium L-Aspartate Magnesium Orotate Magnesium Oxide Powder Magnesium Stearate Maltitol Maltodextrin Maltol FCC Manganese Gluconate Mangosteen 10% Mangosteen 30% Mangosteen Fruit Powder Mannitol Marshmallow P.E. 5:1 Massularia Acuminata Extract MCH 20 Mesh Hydroxyapatite
MCT 50% Powder CWD Melatonin Menthol USP Methyl Cyclopentenolone Methylcobalamin Methylcobalamin 1% Microcrystalline Cellulose Milk Thistle 80% Silymarin Milk Thistle 80% Silymarins Milk Thistle P.E.5:1 Mixed Tocopherol 70% Mixed Tocopherol 90% Moringa Leaf Extract Moringa Leaf Powder MSM 20-40 Mesh MSM 40-60 Mesh MSM 40-80 Mesh MSM 80 mesh (with Anticaking) MSM Granular Mucuna Pruriens P.E. 4:1 Mulberry Leaf Powder
N&A Blue Raspberry Flavor N&A Fruit Punch Flavor N&A Watermelon Flavor N-Acetyl D-Glucosamine N-Acetyl L-Cysteine N-Acetyl L-Tyrosine N-Acetyl-L-Cysteine (Vegan) Nattokinase 20,000 fu/g Neotame Niacin (B3) Niacin Feed Grade Niacinamide (B3) USP
Chenguang Biotech Group Co., Ltd (CCGB, Stock Code 300138) is the leading manufacturer and supplier of plant extracts across the world, lists in China’s Top Five Export Enterprise of plant extracts and is the recognized largest global supplier of Paprika Oleoresin, Capsicum Oleoresin. CCGB is certified by CNAS, ISO9001, ISO22000, ISO14001,OHSAS18001, KOSHER, HALAL, FAMI-QS, CMS, SEDEX and FDA registered.
Olive Leaf P.E. 20% Oleuropein Olive Leaf P.E.10% Oleuropein Olive Leaf P.E.10% Hydroxytyrosol Organic Bilberry Extract Organic Blueberry Extract Orotic Acid Anhydrous
PABA Panax Ginseng 10% HPLC Panax Ginseng Root 3% HPLC Panax Ginseng Root 5% HPLC Parsley Leaf Powder Pea Protein 80% Pea Protein 85% Peppermint Oil Phenibut HCL Powder Phosphatidyl Serine 20% Phosphatidyl Serine 50% Phytosterol Pine Bark Extract 20:1 Pine Bark P.E. 95% (PROAN) Pineapple Juice Powder Policosanol 99% (OCT) 60% Polydextrose Polyglycerol Esters Of FA Pomegranate Juice Powder Pomegranate P.E.40% Ellagic Acid Pomegranate P.E.90% Ellagic Acid Portulaca Oleracea P.E. 5:1 Potassium Bicarbonate Potassium Carbonate Feed Grade Potassium Carbonate Food Grade Potassium Chloride Potassium Gluconate USP Potassium L-Aspartate Potassium Orotate Potassium Sorbate Granular Povidone K-30 PQQ Disodium Salt Propylene Glycol Purple Sweet Potato Pigment Pyridoxal 5 Phosphate Pyridoxine (B6) HCL Powder Pyrroloquinoline Quinone Acid
GRAPE SEED P.E. 95% • Starting material: Grape seeds from Europe (France and Italy) • Guarantee high oligomeric proanthocyanidins content • Capacity up to 500 tons annually • Largest Grape Seed Extract factory in the world
KEY INGREDIENTS: • Lutein
• Grape Seed Extract
• Red Yeast Rice
• Green Coffee Bean Extract
CHENGUANG BIOTECH GROUP CO., LTD chenguang.ingredientsonline.com
Quercetin Dihydrate 98%
Raspberry Fruit Powder Raspberry Ketone 99% Red Beet Root Powder Red Clover P.E. 10:1 Red Clover P.E. 8% Red Pitaya Fruit Powder Red Rasberry Extract 4:1 Red Yeast Rice P.E. 0.2% Resveratrol 20% Resveratrol 50% Resveratrol 98% Rhodiola P.E. 3% Salidroside Rhodiola PE. 1% Rosavin (Organic) Rhodiola PE. 1% Salidroside (Organic) Rhodiola PE. 5% Salidroside (Organic) Rhodiola Rosea P.E. 9% Rosavins Riboflavin (Vitamin B2) USP Riboflavin 5 Sodium Phosphate Ribonucleic Acid Rice Protein 80% Rosemary Extract Rutin 95-102%
S-Acetyl-L-Glutathione SAMe Tosylate Disulfate Saw Palmetto 95% Powder Schisandra P.E.5% Schisandrins Schisandra P.E.9% Schisandrins Sea Berry Pure Fruit Powder
Shiitake Mushroom extract Silicon Dioxide Sodium Acid Pyrophosphate Sodium Ascorbate USP Sodium Ascorbyl Phosphate Sodium Benzoate Granular USP Sodium Benzoate Powder Sodium Beta Hydroxybutyrate Sodium Citrate Sodium Copper Chlorophyllin Sodium Gluconate Sodium Hyaluronate Sodium Hyaluronate 1% Solution Sodium Lactate Powder 90% Sodium Starch Glycolate Sodium Tripolyphosphate Sorbitol Powder Soy Lecithin Soy Protein Isolate 90% Spirulina (Organic) Spirulina Powder St John's Wort P.E. 0.3% Star Anise P.E. 10:1 Stevia P.E 98% Rebaudioside Stevia P.E. 90% Stevia P.E. 95% (RA 95%) Sucralose Sulbutiamine Sweet Tea 80% Rubusoside
Taurine (Anti-caking) 100 Mesh Taurine Regular 40-80 Mesh Taurine (Anti Caking) 40-80 Mesh
China’s leading manufacturer of
SODIUM HYALURONATE Supplying quality products certified with ISO 9001, ISO 14001, OHSMS, KOF-K Kosher, Halal and GRAS at Factory Direct competitive prices. We specialize in customization for specific Molecular Weight from 3000 - 2,400,000 Daltons. PRODUCTS Sodium Hyaluronate - Food & Cosmetic Grade Sodium Hyaluronate 1% Solution
SHANDONG FOCUSCHEM BIOTECH CO., LTD focuschem.ingredientsonline.com
Tetrasodium Pyrophosphate Theobromine Thiamine HCL Thiamine Mononitrate Titanium Dioxide TPGS Trehalose Tribulus P.E 40% Saponins Tribulus P.E 45% Saponins Tribulus P.E 60% Saponins Tribulus P.E.95%saponins (Organic) Trimagnesium Phosphate PTA-HYD Turmeric Oil Turmeric Root P.E. 95% Turmeric Root PE95% (Eurofins) Turmeric Root Powder 80 Mesh Turmeric Root PE.95% (BDMC+DMC50) TwinTiger Glutathione Reduced
Vitamin K2 MK-4 1.3% Oil Vitamin K2 MK-7 1.3% Oil Vitamin K2 MK-7 0.2% Powder Vitamin K2 MK-7 0.2% Oil Vitamin K2 MK-7 0.5% Oil Vitamin K2 MK-7 1.0% Powder Vitamin K2 MK-7 1.3% Powder Vitamin U VitaminK2 MK-7 1.0%PD (Natural)
Vitamin Acetate 1000000IU/G Feed Grade Vanillin Vitamin D3 500,000 IU/G Feed grade Vitamin A Palmit Oil 1,700,000 IU/G Vitamin A Palm 500,000 IU/G Vitamin A Palmitate 250,000 IU Vitamin D3 CWS Powder 100,000 IU/G Vitamin D3 Oil 1,000,000 IU/G Vitamin E 50% SD CWS Powder Vitamin E 50%Powder Feed Grade Vitamin E Acetate Oil Vitamin K1 1% Powder Vitamin K1 Oil USP
Whey Protein Conc. 80 (Instant) Whey Protein Isolate 90 (Instant) White Tea Extract 90% Polyphenol White Willow Bark P.E. 15% Wild Yam 6% Saponins Wolfberry P.E. 40% Polysaccharid Wolfberry P.E. 50% Polysaccharid
Xanthan Gum 80 Mesh Xylitol DC Xylitol Granular USP Xylitol USP
Zeaxanthin 20% Zeaxanthin 20% Oil Suspension Zeaxanthin 5% Zeaxanthin 5% Beadlet Zinc Carnosine Zinc Gluconate Dihydrate Zinc Lactate Powder Zinc Oxide USP
Shandong Jincheng Bio-pharmaceutical Co., Ltd is honored as National High-New Technology Enterprise. Main products are manufactured by microbial fermentation technology and advanced biological extraction & purification technology.
MAIN PRODUCTS: • L-Glutathione Reduced • S-Adenosyl-L-Methionine (SAMe) • Ademetionine Disulfate Tosylate • Ademetionine 1,4-Butanedisulfonate • Pyrroloquinoline Quinine Disodium Salt (PQQ) • Yeast β-Glucan • α-Ketoglutaric Acid Series of Products
NEW PRODUCTS: • Astaxanthin • L-Alanine • L-Hydroxyproline • β-Carotene We hold GMP, Kosher and Halal certificates. Glutathione has got DMF registration in Japan, Korea and India.
HIGH-TECH MANUFACTURER specialized in Chinese Medicine APIs and Natural Plant Extracts
Ningbo Herb is a high-tech manufacturing enterprise specialized in proprietary Chinese medicine APIs and natural plant extracts. With a strong commitment to quality control and adhering to strict GMP standard, Ningbo Herb owns drug, food and food additive production licenses, including HACCP, CQC, ISO9001:2008, NSF cGMP, QS, OU Kosher, Halal and organic certifications. Ningbo Herb is also a Good Extraction Manufacturing Practice Certified Supplier, certificated by NSF & CCCM. Ningbo Herb strictly controls every step from raw material selection, production and packing until the product is delivered. The R & D and Testing Center is 2,000 square meters with internationally advanced laboratory equipment including HPLC, GC, AAS, UV and TLC to monitor bio-active ingredients, solvents residue, heavy metals, pesticide residue and microbe.
• Black Mulberry Fruit Extract 25% Anthocyanins UV, EP6.8 Method
• Olive Leaf Extract 20% Hydroxytyrosol HPLC
• Black Mulberry Fruit Powder 1.0-2.0% Anthocyanins UV
• Polygonum Cuspidatum Extract Resveratrol 98% HPLC
• Curcuminoids Cyclodextrin Complex 15% Curcuminoids HPLC
• Rhodiola Rosea Root Extract 3% Rosavin HPLC
• Ginkgo Biloba Leaf Extract 20:1 Extract Ratio
• Rhodiola Rosea Root Extract 3% Rosavins / 1% Salidrosides HPLC
• Ginkgo Biloba Leaf Extract GFG 22-27% / GTL 5.4-6.8% / GA <5ppm HPLC [USP38/NF33]
• Rhodiola Rosea Root Extract 5% Rosavins / 2% Salidrosides HPLC
• Ginkgo Biloba Leaf Extract GFG 24% / GTL 6% / GA < 10ppm HPLC [CP2015]
• Turmeric Oil
• Polygonum Cuspidatum Extract Polydatin 98% HPLC
• Turmeric E100 Curcumin 95% HPLC
• Grape Seed Extract 95% Proanthocyanidins (OPCs) UV
• Turmeric Oleoresin Color Value E200 UV
• Grape Seed Extract 95% Proanthoycanidins (OPCs) / Polyphenols 85% UV
• Turmeric Root Extract 95% Curcuminoids HPLC (Bisdemethylcurcumin + Demethylcurcumin >50% HPLC)
• Huperzia Serrata Herb Extract 1.0% Huperzine-A HPLC
• Turmeric Root Extract 95% Curcuminoids HPLC, USP
• Mucuna Seed Extract 15%/99% L-Dopa HPLC
• Turmeric Root Extract Granular 95% Curcuminoids HPLC, USP
• Olive Leaf Extract 10%/20%/40% Oleuropein HPLC
• Turmeric Root Powder 80 Mesh, Color Value E5-E10 UV
Ningbo Traditional Chinese Pharmaceutical CORP. Phone: +86-574- 8611-1716 | USA Mobile: +1-626-363-3319 | Fax: +86-574- 8611-5767 Email: firstname.lastname@example.org & email@example.com | Website: www.ningboherb.com Address: No. 525, Yuanbaoshan Road, Beilun District, Ningbo, China
NEW FDA DIETARY SUPPLEMENT GUIDANCE:
Unnecessarily high requirements for safety factors based on animal studies Ray A. Matulka, Ph.D.
he FDA’s new guidance document on new dietary ingredient notifications (NDINs) and related issues (1) contains answers to several questions, one of which is “what safety factors should be used for determining adequate daily intake (ADI) levels of the dietary ingredient if only animal studies are available?” The answer to this question may be surprising to most in the dietary supplement and food industry as the revised draft guidance document recommends far more rigorous preclinical studies be conducted than what is typically accepted by FDA’s Center for Food Safety and Applied Nutrition (CFSAN) as sufficient when evaluating notifications of Generally Recognized As Safe (GRAS) conclusions for ingredients to be added to food. For food additives and, by extension, GRAS substances, the FDA has defined “safe” as “a reasonable certainty in the minds of competent scientists that the substance is not harmful under the intended conditions of use” (2). The safety standard for dietary supplements, in contrast, is that the dietary ingredient, when used under the conditions recommended or suggested in the labeling of the dietary supplement, “will reasonably be expected to be safe.” A “reasonable expectation” standard is materially less than a “reasonable certainty” standard. To determine the safety of food ingredients and dietary supplement ingredients (as well as drugs), studies are often conducted in laboratory animals at levels that are typically many times greater than the anticipated amount that will be expected to be consumed on a daily basis. The difference between the level of expected daily intake by humans and the level of intake by laboratory animals that did not have an adverse effect on the health of the animal (i.e., the no observed adverse effect level, or NOAEL) can be thought of as a “margin of safety” (MOS).
INGREDIENTSONLINE.COM • SPRING 2017
According to the NDIN guidance document, the MOS that should be used depends on whether the NOAEL is derived from a chronic or a subchronic study as well as the number of studies that have been conducted. The guidance states that if the NOAEL is from a chronic study (one year duration or longer) in animals, the safety factor to be used is typically 100. If a subchronic study (typically three to six months in duration) is used for the extrapolation, an additional safety factor is warranted. If data from two subchronic studies is available, with a least one of them being performed in a non-rodent species, an additional safety factor of 10 should be introduced for a combined safety factor of 1000. It is assumed, but not stated, that
The FDA qualifies its recommendations by stating that the safety factors are “approximate values, which can vary with the specific data that are available.” the NOAEL used for the risk assessment should be the NOAEL for the most sensitive species. The FDA states in the guidance that, if only a single subchronic rodent study has been performed, a safety factor of 2000 should be applied to the NOAEL if “there is no toxicity to the rodents at the maximum tolerated dose.” The FDA qualifies its recommendations by stating that the safety factors are “approximate values, which can vary with the specific data that are available.” A greater safety factor may be appropriate if toxicity is severe or variation in human sensitivity is expected to be great, and
a smaller safety factor may be appropriate if subchronic studies in rodents and non-rodents showed no adverse effects. The FDA accepts that GRAS ingredients can be used in dietary supplements (as excipients) or as dietary ingredients; therefore the same standard for safety factors that the FDA accepts for ingredients that are notified as GRAS should, in theory, be applicable to the use of substances in dietary supplements, keeping in mind that the food ingredient safety standard is the higher threshold of “reasonable certainty,” compared to the “reasonable expectation” standard for dietary supplement ingredients. A review of the substances that were successfully notified to FDA as GRAS in 2015 by scientific procedures (N = 45) and received a “no objection” letter reveals that 20 of the conclusions of GRAS status relied on data from subchronic studies in rats (and no second species) to provide evidence of safety (3). Several of these 20 substances were enzymes that were used at low levels in food and readily met the NDIN requirement of a margin of safety (MOS) of 2000 between the subchronic NOAEL in rats and the estimated daily intake (EDI), however, other substances (including some enzymes) had a MOS less than 2000 between the subchronic NOAEL in rats and the estimated daily intake (EDI), such as cellulose from Penicillium Funiculosum (MOS = 639), lactase from Bifidobacterium Bifidum produced in Bacillus Subtilis (MOS= 431), xylanase from Trichoderma Reesei (MOS =412), algal oil from Schizochytrium sp. (MOS = 40) and rice hull fiber (MOS = 8.1). The latter two ingredients are macroingredients with recognized limitations in dosing in animal studies to less than 15% of the diet (approximately 7500 mg/kg bw/day in rats) due to the ability of these substances to affect nutrient balance (4). Although the FDA guidance states that “a lower safety factor may be appropriate if subchronic
studies in rodents and non-rodents showed no adverse effects,” it does not mention whether a lower safety factor would be acceptable if only it subchronic studies were performed in rats. Because large amounts of fiber would be expected to cause the same effects in non-rodents as rodents, it would be a waste of animal resources if studies on fiber (or other macroingredients) were required in a second species to be able to justify the use of a safety factor lower than 2000. Regardless of the extent of historical consumption of an isolated component of food (e.g., if the dietary ingredient is something as well-studied as an isolated fiber, protein, or antioxidant from a food source), the guidance does not allow for a reduction in the type and extent of safety studies that need to be conducted; the guidance primarily focuses on the intended demographic (adults, children or women of childbearing age) and if the ingredient is to be consumed on a chronic basis, or only intermittently to determine the types and numbers of safety studies that need to be provided to show safety of the ingredient. No such focus is made for food ingredients, as food ingredients are expected to be consumed by all adults and children above the age of two.
Of the 25 other substances that were notified as GRAS in 2015, two (Luo Han Guo fruit extract and phosphatidylserine from sunflower) relied on safety data from subchronic studies in rodents and nonrodents, meeting the criteria for a safety factor of 1000 for extrapolations mentioned above. Clinical studies also were performed with phosphatidyl serine from sunflower, however, the longest duration was six months. Although the guidance states that “if human data from chronic toxicity or ADME (absorption, distribution, metabolism, and excretion) studies (typically one year in duration) are available, a safety factor lower than 100 may be appropriate,” the guidance does not state whether performance of clinical studies shorter than one year has any bearing whatsoever on a recommended safety factor. It is believed by the author that the FDA meant to refer to data from chronic toxicity studies conducted in animals, as opposed to human chronic toxicity data, but this still would not address the usefulness of clinical studies that did not evaluate tolerability. Alternatively the FDA meant to discuss human tolerability studies, and not chronic toxicity studies. Therefore, it is reasonable to assume that a safety factor of 1000
would be required from the studies that were performed in order for Luo Han Guo fruit extract and phosphatidylserine from sunflower to be used in dietary supplements. The safety factors for these substances (415 and 200, respectively) were adequate for them to receive a “no objection” letter from the FDA when the intended use was notified as GRAS but are less than 1000, effectively eliminating them from consideration as dietary supplement ingredients if only an NDIN was sought. Of the remaining 23 substances, 12 included chronic toxicity studies in rodents and/or non-rodents, as well as subchronic studies in rodents, satisfying the NDI guidance criterion for a safety factor of 100. Subchronic studies in non-rodents and/or human clinical and/or pharmacokinetic data were included for some of these substances. The safety factors for 10 of these substances were greater than 100, satisfying the NDI criterion. Safety factors for two of the three remaining substances in this category could not be calculated due to lack of determination of an EDI in the GRAS, and the safety factor for the third substance (lecithin from canola) was 11.25, considerably lower than 100. The testing paradigm for lecithin from canola included subchronic toxicity
studies in both rodents and non-rodents, plus a chronic study in rodents, but these still would not pass the NDI criterion for use of a safety factor of less than 100 because human clinical or pharmacokinetic studies were not conducted for the material. The majority of the remaining 11 substances that were notified as GRAS in 2015 relied on data from subchronic rodent studies (some of which were less than 90 days in duration), in addition to short term clinical or pharmacokinetic studies in humans. Seven of these substances had safety factors considerably under 100, yet they were notified as GRAS. Like several other substances that were notified as GRAS in 2015, these GRAS substances that received “no objection” letters from FDA on their intended uses in food would not meet the strict testing requirements of new dietary ingredients stated in the draft guidance if the data set had been submitted to the FDA as an NDIN. The overriding conclusion from this analysis is
that the evaluation of the safety of ingredients under draft NDIN guidance requires a greater number of preclinical studies, as well as human tolerability or pharmacokinetic studies in many instances, compared to food ingredients that also have gone through a notification process with the FDA. The number and complexity of animal studies stated in the guidance for dietary ingredients makes it highly unlikely that any ingredient other than an enzyme could achieve the types of safety factors the FDA wants to see for NDIs without performing long term and unnecessary tests in animals and humans, making the safety testing for dietary ingredients cost-and time-prohibitive, essentially blocking the ability of dietary supplement companies to innovate with new ingredients. While the author is an advocate for thorough testing of ingredients added to food and dietary supplements, there needs to be some recognition of the characteristics of the ingredient that could impact the testing paradigm for dietary supplements and reduce redundant or unnecessary preclinical studies, like there is for food ingredients.
Ray A. Matulka, Ph.D. is the Director of Toxicology at Burdock Group, a food safety consulting firm headquartered in Orlando, FL. Dr. Matulka has more than a decade of experience in the analysis of toxicity data and conducting safety and risk assessments. He earned a doctorate in toxicology from the Medical College of Virginia and has postdoctoral experience at both Boston University School of Medicine and the University of North Carolina. He has industry experience at the Nebraska Dept. of Environmental Control and as a senior genetic toxicologist at Genesys Research in North Carolina. He is co-author of two book chapters and has authored over 30 publications since obtaining his doctoral degree. Dr. Matulka has experience presenting information to the FDA, USDA and EPA.
References FDA (2016). Dietary Supplements: New Dietary Ingredient Notifications and Related Issues: Guidance for Industry, available at http://www.fda.gov/downloads/ Food/GuidanceRegulation/GuidanceDocumentsRegulatoryInformation/ UCM515733.pdf. 21 CFR 170.3 (i). FDA (2016). Substances Generally Recognized as Safe Final Rule, available at https://www.federalregister.gov/documents/2016/08/17/2016-19164/ substances-generally-recognized-as-safe. Borzelleca, J.F. (1992). Macronutrient Substitutes: Safety Evaluation. Reg. Tox. Pharm. 16: 253-264. Hayes, A. Wallace, editor. Principles and Methods of Toxicology. 4th ed. Philadelphia: Taylor & Frances, USA; 2001. Disclaimer: This article is contributed and not the opinion of ingredientsonline.com. Editorial contributors assume responsibility for their published works.
Collagen Type II
Greentech Biochemicals Co., Ltd. is a sales company on behalf of our cooperated manufacturers, especially for the products of Chondroitin Sulfate, Collagen Type II and Keratin. The brand “Greentech” has a good reputation all over the world based on our 19 years experience plus NSF and cGMP quality control system. We also can supply HALAL, ISO, DMF and EDQM supported documents as required. We are confident that you will discover Greentech Biochemicals Co., Ltd. is a perfect and valued supplier once you choose our products.
GREENTECH BIOCHEMICALS CO., LTD. greentech.ingredientsonline.com
New fourth generation of dietary supplement ingredient XinDu Bio-Tech, LLC was founded at 496 Highway 64 E, Conway, Arkansas in July, 2014, with an area of 27,000 m² and building area of 6,000 m². XinDu Bio-Tech industry strategic positioning: the company has been building an annual production line output of 50 tons of Hericium Erinaceus “Mycelium” and has successfully developed core technology products with our own intellectual property — a series of Hericium Erinaceus Mycelium materials which are rich in multiple bioactive compounds. These bioactive compounds and fungi polysaccharide material are obtained from the “Biotransformation”. Directional culturing and bi-directional transformation, as our new-generation fungus technology, innovatively add
different health-supportive Chinese medicinal herbs to nutrient mediums to form functional mediums, and scientifically-optimize combinations of nutrient mediums and functional mediums. Due to the implementation of "directional culturing and bi-directional transformation," in addition to the acquisition and retention of the active ingredient, Hericium Erinaceus can produce biological response modifiers (BRM) with high added value during the secondary metabolism, namely fungi polysaccharides, fungi proteins and fungi cellulose. These kinds of compound active substances from the “biotransformation” are produced under the control of lowtemperature technology with a wide range of human health support. The production process is totally green, natural and magical, which provides the best sources for a new generation of dietary supplements materials.
FUNCTIONAL MEDIUM FORMULA
Kudzu Mycelium (HTJ-U-B24-2)
Immune system health
Kudzu Mycelium (HTJ-U-B24-2) [Fungi polysaccharide 10%, fungus protein 10%, fungi cellulase 30cu/g, kudzu (puerarin), red ginseng(panaxoside), radix paeoniae alba (paeoniflorin), yam.]
Kudzu Mycelium (HTJ-U-B24)
Cardiovascular & cerebrovascular health
Kudzu Mycelium (HTJ-U-B24) [Fungi polysaccharide 30%, fungus protein 10%, fungi cellulase (60cu/g), kudzu (puerarin), safflower extract (hydroxysafflor yone A, salvianolic acid B), chuanxiong extract (ferulic acid)]
Lion`s Mane Mycelium (HTJ-U-A1)
Stomach & digestive system health
Lion`s Mane Mycelium (HTJ-U-A1) [[fungi polysaccharide 5%, fungi protein 15%, fungi cellulase 90cu/g, radix paeoniae alba (paeoniflorin), rhizoma corydalis (tetrahydropalmatine), rhizoma cyperi, kaempferiae]
You’re invited New Generation of Dietary Supplement Ingredient Mushroom Bio-Active Material Presentation
June 6, 2017 | 9am – 5pm XinDu Bio-Tech LLC 496 Hwy 64E, Conway, Arkansas, USA
To learn more and RSVP, contact Joe Lexue: firstname.lastname@example.org or call 501-336-0077
MARKET TRENDS UPDATE By Tony Xue | General Manager, ingredientsonline.com Shanghai
ASCORBIC ACID SERIES
Due to the price increase of corn and coal, facility maintenance and environmental control for reducing pollution that started in the middle of 2016, Vitamin C prices continued to increase until the end of 2016. The market price is currently stable at historically high levels from the past five years. Most Vitamin C manufacturers believe prices will be stable at current levels. There is still a huge production capacity in China and we remain cautious about the Vitamin C market of 2017. In the next few months, the price of Vitamin C derivatives (Sodium Ascorbate, Calcium Ascorbate and AA DC97 Granular) may still continue to increase due to price increases of raw Ascorbic Acid Powder from the past six months.
In the first half of 2016, the price was stable but started to increase in the second half. This trend is still going on and the cost increase is a result of increased energy costs. Also, the chemical starting material increased by 30-50% per one of the major factories. With more and more investment to reduce the pollution, the price will stay firm or increase in 2017.
BCAA As a mainly feather duck/hair hydrolyzed amino acid, the L-Leucine Regular (animal source) price has increased since the middle of 2016 due to the governmentâ€™s environmental control restrictions. For now, prices have stopped increasing and are stable. Due to very high production costs, we believe the price of L-Leucine Regular may be stable at current level. Now, the price of L-Leucine (fermentation, corn source) is almost the same as animal source L-Leucine. L-Valine and L-Isoleucine prices are very stable, so Instant BCAA prices are also very stable.
BERBERINE EXTRACT More and more brands in U.S. market have started to put this ingredient into their product line. The price is adjusted based on harvest and season. In the winter, it will hit the high end, and in summer, it will turn back to normal. Overall, the price is stable. This ingredient has been used as traditional Chinese medicine for centuries and new studies are carried out for new benefits continuously. The U.S. demand will continue to increase in the coming years.
BLACK RICE EXTRACT 25% ANTHOCYANIN The demand has increased by 30-40% annually. The price was stable from 2014 to 2016, but due to the large demand in 2017 and the limited harvest in 2016, the price is predicted to increase by 20-30%.
INGREDIENTSONLINE.COM â€˘ SPRING 2017
CHONDROITIN SULFATE The slaughter scale this spring is far less than last winter which leads to a shortage of starting material for chondroitin. One of the major factories has been shut down by the government and required to improve their pollution treatment. The quote from the major output area is rising and we believe this trend will remain for the first half of 2017.
CREATINE MONOHYDRATE On one side, the starting material cost has increased. On the other side, a new production facility has come into the market and tries to gain market share with low prices. So, there is some difference in price from different manufacturers, but generally, prices are stable.
DHEA Cost of yam diosgenin (the mainly raw material of DHEA) is increasing and the price of DHEA (yam origin) has also started to increase moderately. Another mature production technology of DHEA is by wood or soy sterol; the price of this kind of DHEA remains stable.
GABA In the past few months, supply was short due to pollution control requirements from the government. However, a major Chinese manufacturer has improved their facility and now meets the governments environmental control requirements, so the supply will continue to improve.
GAMMA ORYZANOL The cost of the raw material will increase, so prices of Gamma Oryzanol will also increase moderately.
JINAN JIUAN ESTER CHEMICAL CO., LTD
GLUCOSAMINE The price of glucosamine has been stable in recent years with some of the factories shut down due to pollution control, however, some of the large-scale factories are doing well. The starting material can be obtained domestically and abroad, and the supply is stable. As a very mature product for joint health, the supply and production are balanced and most factories believe the trend will be stable in 2017.
LEADING SUPPLIER OF HIGH QUALITY Choline, Betaine, DMAE Bitartrate and Pyruvate Products
INOSITOL The price is at historically low levels thanks to usage cost reduction and increase in market demand. Due to abundant supply, prices may be hard to increase through Q2, 2017.
INULIN Dietary fiber foods are very popular in the U.S. and worldwide, and Inulin is a hot dietary fiber and prebiotics ingredient. One of the most reputable manufacturers says market demand of Inulin keeps increasing in recent years and they expect demand will keep increasing in 2017. Prices will keep stable as factories have great supply capability.
Betaine Anhydrous Betaine Citrate Betaine HCL Betaine Monohydrate Calcium Pyruvate Choline Bitartrate (L&DL) Choline Chloride
Choline Dihydrogen Citrate Creatine Pyruvate DMAE Bitartrate (L&DL) Potassium Pyruvate Pyruvic Acid Sodium Pyruvate
L-ARGININE AND L-ARGININE ALPHA KETO GLUTARATE Since the major factories are shut down in China, the supply and price has increased since the middle of 2016. The supply right now has slightly improved due to some Daseng origin arginine that has stepped into the Chinese market. This has helped, and keeps the arginine derivatives market from going crazy, but just hot and firm. The hydrolyzed arginine production is still on hold without resuming schedule.
L-CARNITINE Market demands of L-Carnitine series products are still increasing steadily; attributed to the demand increase in weight loss products and infant formula milk powder. New factories have stepped into production in the past two to three years, increasing supply. Prices have continued to fall and current prices have reached the lowest point in recent years. However, facing the increasing pressures of the cost of raw materials, and labor and pollution control, L-Carnitine prices may rebound in the first half of 2017.
L-CITRULLINE Currently, the supply ability is still less than past years due to the unstable production status of two major manufacturers. However, supply and demand are at a balanced status. These two manufacturers may recover in the next few months, so the L-Citrulline market may go back to weak, and price may start to drop.
R&D and technical support from Chinese Academy of Sciences and Shandong University ISO9001, ISO 22000 and FSSC 22000 Compliant Kosher and Halal with GMP workshop
Please email email@example.com directly for products not listed at jiuan.ingredientsonline.com
L-LYSINE MONO HCL GRANULAR
Price of feed grade L-Lysine has dropped, so L-Lysine Mono HCL Granular Food Grade has also dropped, and the supply is abundant.
The pollution caused by Melatonin production is great; therefore supply is influenced by the Chinese governmentâ€™s environmental control policy and actions. For now, manufacturers still have many orders on hand and lead-time is longer. We predict that price will keep increasing in 2017.
L-METHIONINE The L-Methionine and DL-Methionine markets are stable. As more and more factories are able to produce L-Methionine by fermentation, the cost has been substantially reduced. We believe the DL-Methionine demand will shrink step by step and L-methionine will be the preferred form. The L-Methionine cost is also much better compared to the last two years.
MSM The price of raw material (DMSO) continues to increase as does the market demand of joint health products. Prices of MSM will be on a steady rise.
LUO HAN GUO EXTRACT
Price was stable from 2014 to 2016 but generally is still on a downward trend. The market demand is increasing but the production capacity has increased even more. It is predicted that the price will keep stable but may come down step by step with more advanced extract technology applied.
As a newer kind of plant-source protein, the demand of Pea Protein remains hot. The price has increased slightly due to one of the major exporters having issues with exporting before the Chinese New Year but now there is no sign that the price will come down. With the increasing demand and popularity over the market, factories are planning to expand the production and we believe the price will remain firm in 2017.
MACA EXTRACT The market demand is growing steadily but the price is coming down step by step over the years due to sufficient starting material harvest. Some new extract facilities and planting areas are still under way and we believe the price will come down a little in the coming months.
PURPLE SWEET POTATO PIGMENT This is a new natural colorant and the demand is stable from 2014 to 2016. The factory advises that prices will increase a little bit due to
TAICANG XINYUE CHEMICAL CO., LTD.
Creatine Monohydrate 80/200 Mesh Creatine Monohydrate Granular Creatine Ethyl Ester HCL Creatine Nitrate Creatine HCL MSM Taicang Xinyue Chemical Co., Ltd is a well-known Creatine Monohydrate factory have almost twenty years of experience in this space. Taicang is certified by ISO9001:2008, ISO14001:2004 and STAR-K Kosher.
increased costs but they will try to keep the production efficient to keep costs competitive and stable.
• Some manufacturers are not running well, some have stopped production due to financial problems and some are changing their marketing strategy, aiming at a high-end market with little success.
RASPBERRY/BLACKCURRANT/ BLUEBERRY/CRANBERRY POWDER
These ingredients are developed for use in dietary supplements, infant foods, solid drinks, ice cream, instant food, diary product, etc. The demand is increasing, yet prices are currently stable for these fruit powders.
The cost to grow Spirulina keeps increasing. The package and transport costs have also increased by 20% for which the factories are trying to absorb on their own. The supply is still good to meet the demand.
RIBOFLAVIN 5 SODIUM PHOSPHATE
The price of Riboflavin is stable for now, so we anticipate that Riboflavin 5 Sodium Phosphate may remain at current levels in next few months.
Stevia is more and more applied to the traditional food chain as well as dietary supplements. As an herbal extract, the price is highly related to the leaves harvested. From 2014 to 2015, the supply was tight and the price was firm. In 2016, the harvest was normal and we believe the price will be stable in the first half of 2017 and stay firm or increase a little bit for the remainder of the year.
SOY PROTEIN ISOLATE 90% The market of Soy Protein Isolate is very mature and stable. The influence factors for market change are from the supply side and the price may keep increasing for the following reasons: • The current price of soy in China has increased by 10% compared to Oct. 2016, and the supply is still tight. • Production costs continue to increase due to pollution control required by the Government.
SUCRALOSE Currently, Sucralose pricing is still on the high end with a stable supply. With the shortage taking place during the latter half of 2016, the price went up too quickly. We believe the market will come back to a rational level step by step.
HUBEI QIANJIANG HUASHAN
AQUATIC FOOD AND PRODUCT CO., LTD.
Glucosamine HCL 20 Mesh GlucosamineHCL 40 Mesh Glucosamine HCL 80 Mesh
PHARMACEUTICAL CO., LTD.
Vitamin E 50% Powder Feed Grade DL-Alpha-Tocopherol Acetate
Glucosamine Sulfate 2KCL 40 Mesh Glucosamine Sulfate 2KCL 80 Mesh Hubei Qianjiang Huashan Aquatic Food And Product Co., Ltd is a company which mainly produces and exports freshwater products, Chitin and its derivations (GAH, Chitosan, Chitosan oligosaccharide, etc). The mainly advantage: have the completely product chain from shrimp to Glucosamine. Certifications: HALAL ISO 220000
Jilin Beisha Pharmaceutical Co., Ltd. always
adheres to the aim of “Quality utmost,
Reputation based”, and has created
an outstanding enterprise management regulation and quality management system. This system includes advanced analytical laboratories, ISO9001 & ISO2200 certifications and the required FAMI-QS certification for feed additives. Jilin Beisha’s advantage is continuous technological innovation and excellent cost control, which provide the capability to focus on the aspects of animal health and nutrition, food additives, as well as the chemical and pharmaceutical industries. This focus allows Jilin Beisha the ability to deliver premium products and service to global customers.
SWEET TEA EXTRACT
TURMERIC EXTRACT (CURCUMIN 95%)
The price was on a rise from 2014 to 2015 due to starting material cost increases but started to decrease in Q3 of 2016. The price is highly related to the harvest that is currently unstable.
The supply of raw materials will be short in 2017. The harvest is poor in the major planting area in India and Burma. India suffered from severe drought in 2016, so output of turmeric is much less than before. Burma is still under civil war which influences export quantity of turmeric. There is a great possibility for price increase of Turmeric Extract series products in 2017.
TAURINE Current Taurine prices have reached their highest point in the past five years due to reduced supply. Some factories have shut down in the past two to three years and actual output from all manufacturers is well controlled to match market demand. Production costs continue to increase (raw material, labor, pollution control) but one main Taurine manufacturer predicted the price for 2017 should remain stable.
THEOBROMINE The price of caffeine (the major starting material of Theobromine) tends to be stable, so the price of Theobromine is also stable. We predict the price will keep stable at least in the first half of 2017. One of the major Chinese caffeine manufacturers is establishing a new facility, so supply capacity will increase in future.
XYLITOL A new environmental control policy has led to a short supply of D-Xylose (the direct raw material of Xylitol), so the supply of Xylitol is also short and the price keeps increasing since Q3, 2016. This trend may continue until the middle of 2017, so prices will continue to increase in the coming months.
OTHER VITAMINS Thiamine, Niacin, Niacinamide, D-Calcium Pantothenate and Pyridoxine HCl are currently stable at a high level and on the same trend with our last report.
Disclaimer: The forecast information is speculation and opinion only. ingredientsonline.com is providing this as a complimentary service and is not responsible for the information contained in this document.
ZHENGZHOU TUOYANG INDUSTRIAL CO.,LTD. PRODUCTS:
Ascorbic Acid 40-80 Mesh Ascorbic Acid 100 Mesh INTRODUCTION: Zhengzhou Tuoyang Industrial Co.,Ltd. was established in 1993, Tuoyang is a famous professional manufacturer specialized in food additive and medical medium in the world. It has ISO, HACCP, OHSAS18001, Kosher, BRC certifications.
SOURCING INGREDIENTS HAS NEVER BEEN SO EASY!!! With ingredientsonline.com, you will not only save time and money, you will have full transparency on every order giving you peace of mind. Hereâ€™s what a few of our loyal customers have to say:
Tina was a great help in providing Step-by-Step instructions for purchasing online. Website is great with easy navigation. Thanks for all your help." Ruchika Agarwal February 06, 2017 Christine Valmy, Inc. I have really enjoyed my relationship with GWI for years. The website is very user friendly and great information. It is easy and adds efficiency to my day. Elizabeth Geisleman February 06, 2017 Rocky Mountain Reagents Customer Service was amazing! A big applause for Steve who helped me through all the steps and made it very easy to purchase my products. The website is easy to use and easy to understand. Mr Rodolfo Millensted February 06, 2017 Vivant Pharmaceuticals Steve it looks like this will be easier than I thought. It took me a while to get to this point but it may be a go for me. Diane Happy January 19, 2017 Enzyme Process
I appreciate the easy to navigate website and great prices. Samples are very easy to obtain as well. Carrie Maslowicz January 19, 2017 Fusion Formulations From first navigating the website to search for products, then through the ordering process, and finally when I had questions after my purchase... everything went smoothly and I was kept informed on my purchases. I was pleased with the process and doubly pleased with the quick responses to my email inquiries after the sale. I will definitely order from IngredientsOnline again! Mr Collin Kirkpatrick January 17, 2017 Gold Medal Supplements Steve was such a great help getting my order in when I was in need of a product! Loved the website, so easy to navigate! Will be doing business online again soon! Yadira Nelson January 13, 2017 Go fast sports and beverage Site is very easy to Use and customer service is very helpful!
My first order was a little confusing, However, I was on the phone with Steve and he walked me right through it. And, the tracking history is great. Kenny Laird January 13, 2017 Clear Creek Pet Products I had my first experience ordering on line with the help of Steve. With his help, it was a lot easier that I had expected. The first time is always the hardest but with his expert help, it went very quickly. Would I do it again??????? ABSOLUTELY. Try it.......you will like it. Miss Maria Polak January 10, 2017 Top Canada Pharmaceuticals Steve is very knowledgeable and great to work with. The introduction of this site has been an even greater advantage to working with GWI/Ingredientsonline. It is easy to order and very easy to see where product is coming from. Mrs Anna Lovis January 10, 2017 Equichem International, Inc
Mrs. Kari Kreiner January 10, 2017 Kapra Cosmetics Inc
INGREDIENTSONLINE.COM â€˘ SPRING 2017
QUALITY CONTROL CORNER
QUALITY CONTROL PROCESS
ere at ingredientsonline.com, ingredient quality and safety are always the number one concern. Our suppliers come from all over the world, which commands that we develop standard procedures to implement the requirements of the Foreign Supplier Verification Program (FSVP) rule under FSMA. Our highly skilled quality control teams conduct hazard analysis for imported foods, evaluate supplier’s performance and conduct foreign supplier verification activities such as audits, sampling, testing and reviewing supplier’s product safety records. We outsource third party labs to evaluate and screen products before shipment. Participation in the FDA’s Voluntary Qualified Importer Program (VQIP) is our goal for the near future.
KNOW YOUR QUALITY
FIVE STEP QA/QC PROCESS 1. MANUFACTURER QUALIFICATION
2. IN-HOUSE LAB TESTING
On-site auditing and qualification
In-house testing and third party testing
Inspecting production capacity and certifications, manufacturer qualifications are conducted with an audit check list consisted of 12 categories and 62 detailed evaluations. In addition, we carefully audit working environment, energy saving and emission reduction based on 17 indicators. All QC procedures are meticulously and regularly carried out for both new and existing manufacturers.
We are capable of testing mesh size, density, microbial and identification by NIR with our in-house lab. In addition to in-house lab testing, new products and new manufacturer origins are sent to a third party lab for quality verification. Before the product is put on our shelves and sold on our website, we review and approve the lab report, guaranteeing each product is of the highest quality.
3. PRE-SHIPMENT INSPECTION
4. MANUFACTURER ORIGINS TRACING
5. CUSTOMIZED SHIPPING
Quality inspection prior to overseas shipment and in the U.S.
Approved manufacturer origins and preferred manufacturers tracking
Record customized shipping instructions
We believe that consistent quality is as important as maintaining exceptional quality. Part of our quality control program includes keeping records of all approved manufacturer origins for our customers and tracking the preferred origins based on their requests. We implemented this process to help our customers with their compliance in cGMP.
Your customized shipping is never compromised. We carefully record all shipping instructions stated on each purchase order such as documentations, lot number, shelf life and special labels, and we make sure each request is procured on time. Every ingredientsonline.com customer can be ensured to receive exactly what they ordered… every order, every time.
Our China-based quality control unit is capable of making inspections prior to overseas shipment. Furthermore, all products we receive in our U.S. warehouses are given a second inspection by our warehouse team. Due to our Triple Check Policy, they review all quality control requirements before the product is shipped to its final destination.
INGREDIENTSONLINE.COM • SPRING 2017
QUALITY CONTROL CORNER
RE FSMA AND FSVP
ith the implementation of FSMA and FSVP, the FDA will continue to monitor and increase strict quality control and quality assurance programs. ingredientsonline.com has been working with an FDA registered laboratory in
preparation for these new regulatory challenges. The total quality solution of the ingredientsonline.com platform will serve as your supply chain solution and quality control firewall. Be sure to watch for additional FSMA and QC information in the next issue and online at ingredientsonline.com.
Bio-Technology Co., Ltd
Sweet Tea Extract Organic Standard Planting Base
SweetMonk TM Featuring
Phenibut Beta Glucan Grape Seed Extract Policosanol 99% min.
Luo Han Guo Extract Organic Standard Planting Base
Stevia Leaf Extract
Enzyme Modified Steviol Glysosides
Maca Extract Berberine HCL
HUNAN NUTRAMAX INC. nutramax.ingredientsonline.com
SALT LAKE CITY, UT APRIL 6
EDISON, NJ APRIL 6
IRVINE, CA JUNE 8
FACTORY-DIRECT GLOBAL SOURCING EVENT
2017 ROADSHOW SERIES AND SEMINAR Join the conversation and attend this free event in a city near you!!! This morning seminar includes continuing education as we bring you leading industry speakers to deliver updates on the unstable regulatory environment. In addition, learn about the factory-direct ingredientsonline.com e-commerce platform including quality control processes, market trends and market intelligence directly from our teams in China, downloadable QC documentation and real-time U.S. inventory, all with complete transparency. We’ve combined education and networking, all packed into a simple and easy format in your backyard. Learn how to SAVE TIME AND SAVE MONEY – Register now, it’s FREE!!
2017 ROADSHOW & SEMINAR SERIES Brings Industry Together at the Local Level
he ingredientsonline.com 2017 RoadShow Series and Seminars brought together the dietary supplement, food & beverage, animal nutrition and personal care industries for a morning of education and networking. While showcasing new features and benefits of the ingredientsonline. com factory-direct e-commerce platform, the RoadShow Series created a positive industry environment at the local level where attendees learned how to save time and money by using the online global sourcing center. The first stop of the ingredientsonline. com RoadShow Series in Phoenix, AZ brought together participants from AHPA, Arizona Nutritional Supplements, Best Life Formulations, Bricker Labs, DMV Nutritionals, IsaGenix, Sun Orchard and more. “With almost 60 registered participants, it was a great success.” said Sherry Wang, Founder
and President of ingredientsonline.com.
“Our goal was to provide an educational environment for the entire industry in a relaxed local setting to encourage more personal engagement and one-onone conversations.” The RoadShows are a simple and easy format that’s close by and sure to save attendees both time and money with personal demonstrations of the ingredientsonline.com platform's features and benefits. Our second stop in Miami, FL brought together local participants from companies like Arnet Pharmaceutical, Celmark Int., Solara Labs, Nutrimedix, Wellytails and Myotrend.
Take advantage of this opportunity to stay current on FSMA and FSVP regulations. Hear from experts to gain insight on supply-chain management. Meet with the ingredientsonline.com team to learn about the features and benefits of this e-commerce platform and how it will save you time and money with complete transparency.
For a list of ingredientsonline.com factory-direct global sourcing events, 2017 RoadShow Series and Seminars, see the back cover. roadshow.ingredientsonline.com
14821 Northam Street, La Mirada, CA 90638
2017 EVENT SCHEDULE
JANUARY ingredientsonline.com RoadShow - Phoenix, AZ Date: Jan. 26 Time: 8:30 am. – 11:30 am. (Continental breakfast starts at 8:30) Location: Doubletree by Hilton, Phoenix/Tempe, AZ
IPPE Date: Jan. 31 – Feb. 2 Location: Georgia World Congress Center Booth #B7781 – Hall B, Atlanta, GA
FEBRUARY IFT Supplier’s Night – Orlando, FL Date: Feb. 21 Location: Caribe Royale Hotel & Conventions Center, Orlando, FL
ingredientsonline.com RoadShow – Miami, FL Date: Feb. 23 Time: 8:30 am. – 11:30 am. (Continental breakfast starts at 8:30) Location: Embassy Suites by Hilton, Miami – Int’l Airport, FL
MARCH IFT Supplier's Night - Anaheim, CA Date: March 8 Location: Disneyland Hotel, Anaheim, CA
Engredea Date: March 9 – 11 Location: Anaheim Convention Center, Booth #563, Anaheim, CA
Food Ingredients China Date: March 23 -25 Location: Shanghai, China
APRIL IFT Supplier's Night - Bonneville Date: April 4 Location: S. Towne Expo Center, Sandy, UT
ingredientsonline.com RoadShow - Salt Lake City, UT Date: April 6 Time: 8:30 am.– 11:30 am. (Continental breakfast starts at 8:30) Location: Hilton Salt Lake City Center, Salt Lake City, UT
IFT – Annual Conference Date: June 25 - 28 Location: Las Vegas Convention Center, NV
JULY NBJ Summit
IFT Supplier's Night – NYIFT
Date: July 17 - 20 Location: Terranea Resort, Palos Verdes, CA
Date: April 5 Location: Garden State Exhibition Center, Somerset, NJ
ingredientsonline.com RoadShow - Edison, NJ Date: April 6 Time: 8:30 am. – 11:30 am. (Continental breakfast starts at 8:30) Location: Hilton Garden Inn, Edison, NJ
Ingredient Marketplace Date: April 18 – 20 Location: Orlando World Center Marriott, Orlando, FL
MAY VitaFoods – Geneva, Switzerland Date: May 9 – 11 Location: Palexpo, Geneva, Switzerland
National Animal Supplement Council (NASC) Date: May 16 – 18 Location: Crowne Plaza, New Orleans, LA
United Natural Products Alliance (UNPA) Date: May 23 – 25 Location: LeFonda on the Plaza, Sante Fe, NM
JUNE ingredientsonline.com RoadShow – Irvine, California Date: June 8 Time: 9:00 am.– Noon (Breakfast starts at 9:00) Location: TBD
IFT Supplier's Night – Longhorn Date: Sept. 22 Location: Embassy Suites, Dallas-Frisco Convention Center, TX
ingredientsonline.com RoadShow Date: TBD Location: Dallas, TX
SupplySide West Date: Sept. 28 - 29 Location: Mandalay Bay Convention Center, Las Vegas, NV
OCTOBER CRN Annual Conference Date: Oct. 18 - 21 Location: Dove Mountain, Marana, AZ
NOVEMBER FI & HI – India Date: Nov. 9 - 11 Location: Mumbai, India
IFT Suppliers Night – Chicago Date: Nov. 9 Location: Chicago, IL
ingredientsonline.com RoadShow Date: TBD Location: Chicago, IL
FI- Europe Date: Nov. 28 – 30 Location: Frankfurt, Germany
CPHI –China Date: June 20 - 22 Location: SNIEC – Shanghai, China
Toll Free: (877) 550-3600 | Email: firstname.lastname@example.org | 14821 Northam Street, La Mirada, CA 90638
ingredientsonline.com™ is an innovative online e-commerce platform providing nutritional raw materials for the Dietary Supplement, Food & Be...
Published on Apr 1, 2017
ingredientsonline.com™ is an innovative online e-commerce platform providing nutritional raw materials for the Dietary Supplement, Food & Be...