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INDIAN DENTAL ACADEMY •

Leader in continuing dental education

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Am I not destroying my enemies when I make friends of them..? - Abraham Lincoln

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Non Genetic: 

Genetic Disorders  

Developmental defects – Malformations Chromosomal Gene - Mendelian

Multifactorial

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Genome: whole set – Polyploidy 4n, 8n etc. Chromosomal: change in chromosome.  

Number: Trisomy, monosomy Structure: Deletion, Translocation etc.

Gene: Submicroscopic.   

Point mutation – single base sequence Deletions Insertions

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Reduction Division (4n-2n) Prophase-1(Synapsis, g.rec)  Metaphase-1  Anaphase-1  Telophase-1 

Equatorial Division (2n-n) Prophase-2  Metaphase-2  Anaphase-2  Telophase-2 


Abnormal number of chromosomes:  

Non-disjunction - Down’s Syndrome Anaphase lag - Turner’s xxx

Abnormal Structure: (normal no)   

Deletion of short arm 5q- Cri-du-chat syndrome Inversion Translocation - Ph Chromosome - t(9:22) CML,

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Simian Crease •www.indiandentalacademy.com


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Mental retardation Neck folds Epicanthic folds Flat facial profile Simian crease Hypotonia Umbilical hernia Leukemia


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Briefly describe congenital disorders? What are mendelian disorders? Examples. What is mutation? Classification? Autosomal Dominant & Recessive disorders? What is a karyotype? Uses What is point mutation? Examples? Polyploidy, aneuploidy, haploidy, diploid?

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www.indiandentalacademy.com • Leader in continuing dental education •

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Ch10/ dental implant courses by Indian dental academy