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IMS Health Global Market Insights Delivering unparalleled insights into healthcare markets around the world


About IMS Health IMS Health is a leading global information and technology services company providing clients in the healthcare industry with comprehensive solutions to measure and improve their performance. End-to-end proprietary applications and configurable solutions connect 10+ petabytes of complex healthcare data through the IMS OneTM cloud-based master data management platform, providing comprehensive insights into diseases, treatments, costs and outcomes. The company’s 15,000 employees blend global consistency and local market knowledge across 100 countries to help clients run their operations more efficiently. Customers include pharmaceutical, consumer health and medical device manufacturers and distributors, providers, payers, government agencies, policymakers, researchers and the financial community. As a global leader in protecting individual patient privacy, IMS Health uses anonymous healthcare data to deliver critical, real-world disease and treatment insights. These insights help biotech and pharmaceutical companies, medical researchers, government agencies, payers and other healthcare stakeholders to identify unmet treatment needs and understand the effectiveness and value of pharmaceutical products in improving overall health outcomes. Additional information is available at www.imshealth.com.

Keeping a close eye on the trends and movements that are shaping the world’s pharma market is absolutely mission-critical to developing proactive, sustainable strategies. The breadth and depth of IMS Health’s Global Market Insights offerings offer unparalleled visibility into current and future market opportunities, enabling better decisions and better business outcomes.

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Section I: IMS MIDASÂŽ Introduction to IMS pharma sales intelligence........................................................... 7 Packaged Offerings........................................................................................................... 9 Pre-packaged data solutions that provide focused, relevant insights

Pharma Solutions............................................................................................................... 19

Solutions that are designed to fit individual business needs and provide optimal value

Section II: IMS Syndicated Analytics IMS Analytics Link™........................................................................................................... 27 An integrated dashboard view of all relevant sales, pipeline, launch, loss-of-protection and deals information

Forecasting.......................................................................................................................... 31 Market, disease and product forecasts at global or country levels Company Intelligence..................................................................................................... 39 In-depth insights covering the strategies and performance of pharma companies around the world

Market Measurement...................................................................................................... 45 Comprehensive market measurements and review of major growth drivers

Lifecycle Management................................................................................................... 53 Strategy maximization from early stage R&D to loss of exclusivity

IMS Analyst Services....................................................................................................... 63 Tailored and informed insights in life sciences from IMS Health experts 3


IMS MIDAS速 Global pharma sales analysis made easy


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IMS MIDAS ® 70+ local market audits consolidated in an integrated viewing & analysis platform Internationalization

Additional features

Maintenance

• Corporations linked to

• Chemical information

• Dedicated team

local manufacturers

• Molecule, KG weight

undertaking ongoing

• International products

• Extended unit info

linked to local products

• Standard Units

• International packs linked to local packs • Consistent pricing levels • Ex-manufacturer • Trade • Public

• Counting Units • Medical info • Diagnosis value, AVDD, cost/day, treatment days • Elements of growth • Currencies

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maintenance • 12 yrs back data • Applying back data changes • Defining & maintaining standards • ATC, NFC • Corporation & product ownership changes


Introduction to IMS Pharma sales intelligence IMS MIDAS ® is a truly unique analysis tool and on-line system that brings together, internationalizes and extends healthcare facts and figures from over 70 countries. For over 30 years, IMS MIDAS ® has been the benchmark measure in the industry. IMS MIDAS ® evolves from the IMS Health ‘building blocks’ that are the national audits. These audits detail estimated pharmaceutical product sales values and volumes, trends and market shares by product, therapy class through retail and non retail channels.

Additional key metrics IMS MIDAS ® offers a unique range of key metrics enhancing the identification and measurement of opportunities in the global marketplace:

IMS MIDAS ® Market Segmentation Rapid, consistent definition of the protected, unprotected and generic markets: identify and evaluate new product development and partnering opportunities.

IMS MIDAS ® Licensing Company profile assessment by product revenue composition: evaluate licensing practices within therapy areas or corporations, access insights into opportunities for partnership and collaboration, analyze corporations’ R&D innovativeness.

IMS MIDAS ® Biologics Global insights into changing treatment paradigms: analyze type of biologics being used in treatments, prescriber preferences and emerging growth dynamics.

IMS MIDAS ® Biosimilars Identification and valuation of the biosimilars market across geographies, therapies and corporations. 7


IMS MIDAS ® automatically translates all the differences inherent to each country into a standard nomenclature, point of view and structure so that you can track and analyze market activity across countries, regions and globally. This level of global analysis supports healthcare companies across multiple business activities:

Corporate strategy • Formulate portfolio direction, investment & divestment. • Identify suitable candidates for M&A: diligence, portfolio analysis. • Identify licensing /partnerships opportunities and strategic alliances.

Geographic expansion • Formulate geographic direction. • Identify opportunities for regional/country alliances and partnerships.

Portfolio management • Monitor performance, market share and competitive positioning. • Ongoing review of market dynamics. • Identify new market opportunities, select line extensions, optimise new launches. • Access data on volume & prices for production strategy.

Pipeline planning • Analyze current business and market trends globally. • Identify opportunities for additional market access and pipeline development: niche opportunities in therapy areas, delivery systems or biosimilars. • Access evidence for selection of long term API candidates including IP positions.

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Packaged Offerings Pre-packaged data solutions that provide focused, relevant insights


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Supply chain management solutions Created specifically for professionals within the pharma supply chain, these solutions provide pre-packaged insights and data selected by IMS experts and include the key insights you need to run your business efficiently and support your strategic decisions

IMS Word Review Molecule............................................................................................ 12 Unique market intelligence on active ingredient consumption

IMS World Review Pack.................................................................................................... 14 Market insights on pharmaceutical packaging sales

IMS Generic Market Development............................................................................... 16 Generic opportunities across the world

Also available (please contact your Account Manager for more information).

IMS World Review Trader Detailed market insights for wholesalers, distributors and trading companies seeking business opportunities worldwide

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IMS World Review Molecule Unique market intelligence on active ingredient consumption IMS World Review Molecule provides a detailed overview of sales and KG volume of over 7000 active pharmaceutical ingredients sold world-wide. The analysis of sales and volume with the option to include dose form and pack details gives powerful insight into the current market and supply trends for pharmaceutical actives. API manufacturers and contract manufacturing organisations will find it indispensable for planning and developing their strategy by analyzing current API consumption patterns and trends across therapy areas and geographies.

Content DATA ELEMENTS

MEASURES

SP *

Module 1 Module 2

SERVICE PACK

KG & IU

STANDARD UNITS

COUNTING UNITS

UNITS

USD/EURO/LCEU/L CD

SECTOR

SALT

REGION

COMBINATIOAN

MOLECULE

MANUFACTURER

COUNTRY

CORPORATION

COMBINATION

BIO-REF-GRP

BIO-PRD

BIO-MOL

BIO-COMP

ALL-BIOCOMP

(MOL LIST)

Module 3

* SERVICE PACK

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Key Questions Answered • How many KG should I produce on a yearly basis to match consumption needs? • Which corporations will be interested in purchasing this API? • Who are the biggest consumers that I should target? • Which delivery form is the most popular and should I invest in?

Delivery Format Online via IMS Health proprietary softwares: IMS SMART, IMS Analysis Manager

Key Features & Benefits • Understand market share, estimate demand and growth evolution of APIs to assess their market potential • Access worldwide, reliable, actionable and up-to-date kilogram and molecule data to make production planning assumptions • Review markets to uncover opportunities that best fit your current technology or specialisation • Identify potential clients and supply opportunities

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IMS World Review Pack Track global formulation changes in pharma packaging IMS World Review Pack provides a detailed overview of value and volume sales of products, dose forms and packs across the world-wide pharmaceutical market. Analysis of sales alongside dose forms and pack details gives powerful insight into the current market size, performance and trend for drug delivery and package systems in any geography.

Content

Data elements included

Measures included

• Sector: retail or hospital

• USD/EURO/LCEU/LCD

• Country/region • Corporation/manufacturer • International product

• Units • Counting Units • Standard Units

• Molecule and molecule combination • International pack description

Service pack

• International pack volume • International pack size • International form (NFC123/ NFC2)

Key Questions Answered • What are the global trends in the packaging and drug delivery market • What is the global opportunity of a new drug delivery technology? • What is the opportunity for growth in emerging markets? • Which corporations will be interested in purchasing this delivery form? In which geographies? 14


Delivery Format Online via IMS Health proprietary softwares: IMS SMART, IMS Analysis Manager

Key Features & Benefits • Understand supply requirements and trends for specific delivery forms and vehicles • Identify the most popular delivery forms • Review markets to uncover opportunities that best fit my current technology or specialisation • Identify potential client and supply opportunities

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IMS Generic Market Development Identify generic opportunities across the world IMS Generic Market Development utilizes the IMS MIDAS ® Market Segmentation and Licensing features to offer unparallelled insights and analysis into generic markets around the world. Generic companies can leverage these insights to analyze global market trends, monitor existing portfolio and identify development or licensing candidates for both small molecules and follow-on biologics.

Content

Optional

SP *

SERVICE PACK

STANDARD UNITS

COUNTING UNITS

UNITS

USD/EURO/LCEU/L CD

SECTOR

SALT

RX VS. OTC

PROTECTION **

PATENT EXPIRY *

MOLECULE

MEASURES

NAME TYPE **

MANUFACTURER

LICENSING *

C123) INT’L STRENGTH

INT’L FORM (NF

L PACK INT’L PRODUCT

INTERNATIONA

CORP. / MANUFA CTURER COUNTRY / REGIO N ESTIMATED PROT ECT EXPIRY ** GENERIC PROD UCT **

(MOL LIST)

Included

CORPORATION

COMBINATION

BIOLOGIC/BIOS

ATC 3

IMILAR

DATA ELEMENTS

* SERVICE PACK

* IMS MIDAS Regional Licensing [Geographic coverage includes Russia, Balkans & Baltics, Middle East

& Africa, South East Asia, Latin America]

** IMS MIDAS Market Segmentation [Geographic coverage includes European Market, North America,

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Asia Major Markets, Australasia, Turkey]


Key Questions Answered • In which geographies do generics have the largest share and in which geographies are they growing at the highest pace? • Which therapy areas offer the best opportunity for future generic launches? • What are the best candidates for acquisitions and partnerships to drive greater market share?

Delivery Format Online via IMS Health proprietary softwares: IMS SMART, IMS Analysis Manager

Key Features & Benefits • Measure global market trends and identify areas of opportunity for additional market access and pipeline across key geographies • Monitor current portfolio performance versus competition, uncover opportunities across new geographies • Identify development candidates through the evaluation of product sales performance alongside their IP position in each country, identify top selling strengths and forms to develop production strategy

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Pharma Solutions Solutions that are designed to fit individual business needs and provide optimal value


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Pharma Solutions Every company has different priorities and business goals. Only IMS MIDAS ® provides the flexibility that allows you to focus your research efficiently on the countries and products you choose using only the metrics that retrieve the insights you need. An IMS MIDAS ® tailored solution can be designed to fit a client’s needs/budget with various “dials” that can be adjusted to optimize the solution including:

• Frequency of reporting

• Geographic coverage

• Therapeutic coverage

• Added value features

Tailored, cost-effective delivery options CUSTOMIZED INSIGHT

PAY AS YOU GO

MIDAS ® UNLIMITED

OFFLINE

IMS MIDAS ® Customized Insights

IMS MIDAS ® Unlimited and IMS MIDAS ® Pay As You Go

When you need access on an ad-hoc basis.

When you need regular access throughout

Studies fully customised to your specific

the year.

requirements that provide information on

Allow you to choose the size of the package

the countries and products you choose,

so that you benefit from increased insight

using only the metrics that retrieve the

across a wide selection and managed costs

insights you need.

whilst retaining the flexibility to handle ad-hoc requests.

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IMS Syndicated Analytics


IMS Syndicated Analytics brings together reports, publications and platforms dedicated to helping pharmaceutical, generic and supply chain companies integrate evidence-based analytics and transform data to access valuable insights across the drug lifecycle.

IMS Analytics Link™.............................. 27

Lifecycle Management....................... 53

The interactive power of connected

IMS Lifecycle – R&D Focus

pharmaceutical insights

Essential intelligence on drugs in

Forecasting............................................. 31 IMS Market Prognosis Intelligence and insights into future market trends

IMS Disease Insights Intelligence and insights into future disease trends

Company Intelligence......................... 39 IMS PharmaDeals The most comprehensive source of information on global life science deals

development worldwide

IMS Lifecycle – Patent Focus Fully evaluated information on the most commercially-significant patents

IMS PharmaQuery Online guide to healthcare and pricing and reimbursement systems in major markets worldwide

IMS Analyst Services........................... 63 Tailored and informed insights in life sciences from IMS Health experts

Market Measurement.......................... 45 IMS Chemical Kilochem Profile Worldwide consumption of specific active ingredients

IMS World Review Worldwide pharmaceutical market review

(Other offerings available through your Account Manager)

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IMS Analytics Link ™ The interactive power of connected pharmaceutical insights


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IMS Analytics Link™ An integrated dashboard view of all relevant sales, pipeline, launch, loss-of-protection and deals information IMS Analytics Link is a web-based dashboard system that combines market intelligence and analytics in a single, integrated and interactive view. Data can be filtered by individual drugs, therapies, companies or countries, enabling superior decision-making and enhanced productivity.

Content

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Key features Connected Analysis

Build Your Own Segments

Analytics Link connects the strategic insight

Build your own segment using our ‘Query

of our analysts with a wealth of integrated

Builder’ function to assemble permutations

data, spanning sales, pipeline, launch,

of drugs, therapies, companies or countries

loss-of-protection and deals intelligence,

according to the way you see the market.

all updated according to a regular frequency cycle, augmented by event-triggered updates.

Seamless Interactivity

For the first time, the deep granularity of IMS

Save time and keep yourself informed by

MIDAS value and volume data is systematically complemented by company-reported sales and analyst consensus forecasts.

activating alerts to constantly monitor the industry segments that matter to you and gain direct access to our content authors via the Ask-the-Analyst function.

Integrated add-on modules Disease

Oncology

Patient Days

Answers two key questions:

Answers two key questions:

• “What are the sales, volumes of drugs in my disease of interest?”

• “What are the sales, volumes of drugs in my tumor of interest?”

• “What are the sales, volumes for my drug of interest across diseases?”

• “What are the sales, volumes for my drug of interest across tumor types?”

• Extends and deepens the Disease module, providing patient days estimate for drugs in over 600 diseases

Provides segmentation of 5-year

Provides segmentation of 5-year historical sales and volume data, spanning over 600 diseases, 6,700 drugs and 37 countries. Search and browse the disease landscape via user-friendly disease terms and the ICD10 taxonomy.

historical sales and volume data, spanning 24 tumors, 100+ molecules, 1,000+ brands, and 8 countries (90%+ of the oncology market).

• Patient Days parameter is calculated by dividing volume (SU) by average daily dose (AVDD) • Patient Days is a method to adjust volume to take into account different daily dosing regimes

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Forecasting Therapy, disease and product forecasts at global or country levels


IMS Market Prognosis ..................................................................................................... 34 Intelligence and insights into future market trends

IMS Disease Insights .......................................................................................................36 Intelligence and insights into future disease trends

Also available (please contact your Account Manager for more information)

IMS Analogue Planner New Product Forecasting new product performance

IMS Analogue Planner Off Product Forecasting end of brand lifecycle & generic performance

IMS Forecasting Service: Generics Analysis Forecasting generics markets at a country level

IMS Forecasting Services Training, analytics and customization capabilities

IMS Therapy Prognosis Global Intelligence and insights into future therapy trends

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IMS Market Prognosis Intelligence and insights into future market trends IMS Market Prognosis is a strategic market forecasting publication that evaluates the impact of key issues on the pharmaceutical and healthcare industries across 49 countries. It provides unparalleled insight into the economic and political issues impacting local pharmaceutical and healthcare markets and identifies and evaluates the events affecting each marketplace. IMS Market Prognosis also provides a 5-year forecast at country, regional and global levels. A unique and comprehensive library of “events” enables marketing, R&D and product teams to fully understand the key dynamics and major drivers that will impact the market.

Content Market and therapeutic class forecasts:

Healthcare environment:

5-year forecasts for hospital and retail

Cost containment pressures, prescribing

sectors and 10 main therapeutic classes

and reimbursement issues, pricing

(ATC1) across 49 geographies.

trends, regulatory and pharmaceutical

Business Environment:

environment reviews.

Assessment of economic and political status.

Key Questions Answered • Which markets should we be targeting in our expansion plans? • What are the regulatory and market developments that will impact our business over the next 5 years? • What are the opportunities, and the potential pitfalls, that are arising in the emerging markets? • Will the expansion of the cost containment measures curb healthcare costs across the APAC region? 34


Delivery Format Delivered through IMS Syndicated Analytics Library, a fully-searchable, interactive portal that includes:

• Instant download into Microsoft Word, Excel and PowerPoint

• Excel forecast tool to access and manipulate the forecast data

• Automatic translation into nine languages including Chinese and Korean

Key Features & Benefits • Unrivaled world perspective on established and emerging markets, helping determine future investments and planning expansion strategies • Evaluations of key economic and healthcare-related issues in each country and identifications of the events shaping local and regional pharmaceutical markets • Validations of forecasts to establish annual targets, and set and manage expectations from corporate headquarters to local subsidiaries

Free sample available! Contact your Account Manager today.

Asian country coverage: Australia, China, Hong Kong, India, Indonesia, Japan, Malaysia, Philippines, Singapore, South Korea, Taiwan, Thailand, Pakistan, Vietnam

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IMS Disease Insights Intelligence and insights into future disease trends IMS Disease Insights is a strategic forecasting publication that explores patient and market dynamics to draw out patient-based forecasts across 9 major countries and key disease areas.

Content Section Outline

Diseases Covered

Geographies

Disease overview & background

Dyslipidemia Multiple Sclerosis Psoriasis NSCLC Breast Cancer Rheumatoid Arthritis Malignant Melanoma Prostate Cancer Neuropathic Pain Asthma & COPD Diabetes (Type 1 & 2) Ulcerative Colitis/Crohn’s Disease Alzheimer’s Disease Colorectal Cancer Stroke Prevention in Atrial Fibrillation Parkinson’s Disease Atopic Dermatitis Psoriatic Arthritis Chronic Pain Multiple Myeloma

Brazil / China /

Patient section • Key insights • Epidemiology • Patient characteristics • Drug-treatable populations Market section • Key insights • Market overview • Emerging landscape Forecast section • Key insights • 2015-2024 forecasts • Base case; total market; class-level market; product-level analysis; key drivers; events; upside/downside scenarios 36

France / Germany / Italy / Japan / Spain / United Kingdom / United States


Key Questions Answered (by disease) • What are the key epidemiology metrics across the major countries? • What is the future size of the patient population? • Who are the current prescribers and how does that vary across countries? • Who is the current market leader and what are their key claims? What attribute do physicians value most? • How many new products will launch in the next 10 years? • Do physicians think they will significantly change treatment? What impact will the new products make?

Delivery Format Delivered through IMS Syndicated Analytics Library, a fully-searchable, interactive portal that includes:

• Instant

download into Microsoft Word, Excel and PowerPoint forecast tool to access and manipulate the forecast data • Automatic translation into nine languages including Chinese and Korean

• Excel

Key Features & Benefits • The most accurate disease insights enabling more comprehensive understanding of the patient and market real world dynamics. • A detailed evaluation of the future of the disease landscape, complemented by a 10-year product-level forecast.

Contact us for a detailed table of contents

• IMS Health gold-standard sales data to enable the development of a more compelling brand strategy. 37


Company Intelligence In-depth company insights covering the strategies and performance of pharma companies around the world


IMS PharmaDeals ............................................................................................................. 42 The most comprehensive information source of global life science deals

Also available (please contact your Account Manager for more information)

IMS Company Profiles Insights into the strategy and performance of the major pharma players

IMS PharmaDeals iReports Interactive syndicated reports on key topics related to deal making

IMS PharmaDeals Services Customised information service to answer ad-hoc queries

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IMS PharmaDeals The most comprehensive information source of global life science deals IMS PharmaDeals is the most comprehensive information source for global life science deals. It delivers comprehensive data and analysis on all aspects of deal-making that allow executives to benchmark deals and track competitors’ deal-making activities.

Content • > 62,000 deal records, continuously updated

• Collated from ~120 publicly available sources

• All major deal types such as licensing, marketing, M&A, J-V’s and research collaborations

• Full global coverage including emerging markets • Financial information (also including SEC documents) • Deal insights and news service (PharmaDeals Review) with a “deal alert” capability • Additional content such as executive interviews, share price info and video tutorials

Key Questions Answered • What are the typical upfront payments for a Phase II product licensing deal? • Who has been active in deals for Alzheimer’s disease drugs? • What deals involving vaccines have been done in the last 12 months? • What are the key deals in this therapy area?

Delivery Format Fully-searchable, online repository with export functionality

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Key Features & Benefits • Fully integrated deal information, constantly edited by in-house deal experts, including press releases, SEC contracts and executive interviews • Easily searchable online portal to isolate relevant deals of interest with visualisations of deal type, indication and development phase • Ability to save searches and deal alerts to timely monitor deal activity

Free trial available! Contact your Account Manager today

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Market Measurement Comprehensive market measurements and reviews of major growth drivers


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IMS Chemical Kilochem Profile .................................................................................... 48 Worldwide consumption of specific active ingredients

IMS World Review ............................................................................................................ 50 Worldwide pharmaceutical market review

Also available (please contact your Account Manager for more information)

IMS Country Review Country healthcare systems and pharmaceutical sales performance

IMS World Review Analyst Insights into leading companies, their product performance and new product launches

IMS World Review Growth Dynamics Executive–ready insights into pharmaceutical market performance

IMS World Review Executive Essential insights into worldwide pharmaceutical sales

IMS World Review Actives & Brands Worldwide sales performance and trends of the top active ingredients and brands

IMS World Review Market Analyzer Sales of pharmaceutical markets, companies and therapy classes

IMS World Review Medical Unique source of sales and medical prescription trend data

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IMS Chemical Kilochem Profile Worldwide consumption of specific active ingredients IMS Chemical Kilochem Profile provides detailed consumption data on specified pharmaceutical active ingredients across 70 countries.

Content Profiles available on a per molecule basis • 3-year KG figures provided as standard with each profile (excel or database format) • 3-year USD & Euros Sales figures can be added as an option (database format only)

Breakdown options: • Molecule, Salt • Molecule, Country • Molecule, Country, Company • Molecule, Country, Company, NFC123 (database format only) • Molecule, Country, Company, NFC123, International Pack (database format only)

Key Questions Answered (by molecule) • What are the worldwide sales in KG and USD? • Which countries have shown the highest growth in consumption over the last 3 years? • Which companies could be a potential partner across mature markets? • Which pharmaceutical forms should R&D strategies focus on?

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Delivery Format Reports are delivered in database format via IMS Dataview proprietary software or electronically via Excel

Key Features & Benefits Understand global consumption patterns and market share, assess most popular pack, identify delivery form for selected molecules to: • Make informed production decisions • Evaluate potential clients and supply opportunities • Optimise your growth and expansion strategy

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IMS World Review Worldwide pharmaceutical market review Comprehensive insights into worldwide pharmaceutical market sales, including market trends and sales analysis and providing sales breakdown by therapy area, product and company.

Content • Pharmaceutical companies: Sales performance of the top 100 worldwide and top 75 by region for the last 5 years with an analysis of 25 fastest growing corporate groups • Therapy areas: Sales and growth trends for the last 5 years, by companies, by region and featuring the largest and fastest growing, selected therapy area profiles with detailed commentaries • Products: 5 year sales for top 150 worldwide and top 50 by region

• New product introductions, by country, by corporation and by therapy class

• New active substances (NAS) featuring five-year sales

• Trends for top 100 NAS and top 50 Biologics

• Countries: Market trends, top 35 companies, top 15 therapy areas, and top 40 product sales performances • Hospital sector: Sales by country, top 50 corporate groups and 15 fastest growing groups, 50 largest and 15 fastest growing therapeutic classes, as well as by leading products

Key Questions Answered • What is the true view of the value of the global pharmaceutical market? • What are the top performing corporations worldwide and in key regions? • What are the fastest growing therapy areas by corporation and region? • What are the top selling products worldwide and by region? 50


Delivery Format Delivered through IMS Syndicated Analytics Library, a fully-searchable, interactive portal that includes: • Instant download into Microsoft Word, Excel and PowerPoint • Excel forecast tool to access and manipulate the forecast data • Automatic translation into nine languages including Chinese and Korean

Key Features & Benefits • A cost-effective strategic analysis tool providing standardised, comparable sales data • Unique global sales analysis by market, company, therapeutic class and product for the last 5 years, growth and market share • Comparisons across countries, companies, therapeutic classes and products, complemented by qualitative commentaries

Free sample available! Contact your Account Manager today.

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Lifecycle Management Strategy maximization from early stage R&D to loss of exclusivity


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IMS Lifecycle – R&D Focus ........................................................................................... 56 Essential up-to-date intelligence on drugs in development worldwide

IMS Lifecycle – Patent Focus ....................................................................................... 58 Fully evaluated information on the most commercially-significant patents

IMS PharmaQuery ............................................................................................................ 60 Online guide to healthcare and pricing & reimbursement systems in major markets worldwide

Also available (please contact your Account Manager for more information)

IMS Lifecycle – New Product Focus Up-to-date intelligence on new product launches worldwide

IMS Pharma Pricing & Reimbursement Concise Guides Guides to healthcare and pricing & reimbursement systems in major markets worldwide

IMS Pharma Pricing & Reimbursement Magazine News, views and analysis of the changing world of pricing & reimbursement

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IMS Lifecycle – R&D Focus Essential up-to-date intelligence on drugs in development worldwide IMS Lifecycle R&D Focus is a powerful database that monitors R&D pipeline progress from discovery to marketed phases (including registered and recently marketed products). All information is edited by a team of pharmaceutical experts who provides evaluation of preclinical/clinical data and pharmacological mechanisms of action as well as information on licensing and partnering opportunities.

Content • Over 36 search fields including:

• Product name

• Indication

• Country

• Mode of administration

• Latest phase of development

• Therapy class code

• Latest phase reached worldwide, as well as country/region development status in relation to a particular indication • Over 6,000 companies, including relationships between licensor, licensees or developers • Essential sales information for over 350 therapeutic classes (updated quarterly), including financial background for the top 10 products, companies and diagnoses • Full commercial summaries including: • Commercial overview • Regulatory progress • R&D progress • Licensing and partnering deals, analysts sales predictions • Scientific summaries with details of pre-clinical and clinical data 56


Key Questions Answered • Which companies are the most active in a given therapy area and which molecules are reaching the latest development phases? • What is the latest clinical trial information published for this new chemical entity? • What are the potential licensing opportunities? • What is the drug pipeline landscape for a company, an indication, or a specific mechanism of action?

Delivery Format • CD-ROM (monthly or quarterly updates) • Access online through: • IMS Customer Portal www.imsportal.com • IMS Analytics Link (weekly updates)

Key Features & Benefits • Access to the most up-to-date information: • Over 32,000 drugs in R&D with over 8,800 drugs in active development worldwide including more than 6,000 biotechnology products, 6,000 companies, 800 drug up dates and around 100 new drugs added each month • Examine R&D strategies against leading companies and drugs by leveraging essential

Free trial available! Contact your Account Manager today.

IMS Health gold–standard sales data

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IMS Lifecycle – Patent Focus Fully evaluated information on the most commercially-significant patents IMS Lifecycle – Patent Focus is a comprehensive database, carefully selected and fully evaluated by an in-house team of pharmaceutical patent experts. It includes estimated patent expiry dates (and the possibility of extensions), patent numbers, as well as originators of late phase and marketed compounds (pharmaceutical and biotech).

Content • Evaluated patent information, covering more than 3,000 commercially significant pharmaceutical compounds, with a total of approximately 230,000 individual patent records in over 120 countries • Full evaluations of pharmaceutical patent families with relevant CAS numbers • Profiles include:

• Patent expiry dates and priority details

• Patent and application numbers

Japanese and USA extensions

• Extensions covered including SPC’s,

• Final product structures available

• Individual country comments

• Litigations

Key Questions Answered • What are the estimated patent expiry dates for competitor drugs? • Have supplementary protection certificates or other extensions been applied or granted for these drugs? • What are the commercially significant patents including product, formulation or process patents for this new compound in R&D? • Which patents are due to expire over the 5 years, and thus creating new generic opportunities? 58


Delivery Format • CD-ROM (monthly or quarterly updates) • Access online through: • IMS Customer Portal www.imsportal.com • IMS Analytics Link (weekly updates)

Key Features & Benefits • Access to the most up-to-date and constantly evaluated information on more than 190,000 patent records worldwide • A cost- and time-efficient service for effective patent searches to anticipate generic launches and identify new business opportunities

Free trial available! Contact your Account Manager today.

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IMS PharmaQuery Online guide to healthcare and pricing and reimbursement systems in major markets worldwide IMS PhamaQuery is an online tool designed to unravel the complexities of pricing and reimbursement. It provides continuously updated detailed information on the rules and regulations, theories and practices, trends and developments, in pricing and reimbursement and includes news and analysis spanning 31 countries, based on extensive selection of primary and secondary sources.

Content • Healthcare system review: Facts & figures, provision & funding, market indicators • Pricing: Prescription drugs, generic drugs, hospital drugs, OTC drugs • Reimbursement: Admission to reimbursement, reimbursement categories, reimbursement prices, hospital reimbursement, changes in reimbursement status and reimbursement prices • Price build-up: Wholesales and retail pharmacy margins and sales tax • Cost containment measures: Industry paybacks, promotional costs, patient co-payments, prescribing controls, generics, Rx-to-OTC switches, parallel trade • Outlook and future developments • Useful contacts, names & addresses, links

Key Questions Answered • How are generic drug prices determined by country? • What cost-containment measures might limit my revenues? • How is the P&R regime changing? • Who are the key decision makers for pricing & reimbursement? • What criteria guide reimbursement decisions? 60


Key Features & Benefits • Learn the processes involved in establishing medicine prices, securing reimbursement, and fixing supply chain margins, fees & taxes • Understand how payers and providers contain costs and learn about prescribing, dispensing and budgetary control mechanisms • Understand how P&R policies will change and learn about upcoming developments that will affect the P&R environment

Free trial available! Contact your Account Manager today.

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IMS Analyst Services Tailored and informed insights in life sciences Informed market insight is critical in the various decision-making steps throughout the pharmaceutical product lifecycle. We realize that commercial departments in small and emerging pharma companies are often resource-constrained and do not have access to a wide range of information sources. IMS Analyst Services help to fill these gaps by providing robust commercial insights into emerging markets at an affordable price level.

Our team of experienced analysts can address a broad range of commercial priorities: Market assessments: the evolution and dynamics of key products, therapy areas, diseases, countries and regional markets Forecasts: sales value and volume at a therapy class, market segment (e.g. generics) or formulation level Company profiles: profiles of privately-owned companies in emerging markets Pipeline and competition assessments: late stage pipelines and competing in-line products by therapy area or indication Deal benchmarks: benchmarking of mergers and acquisitions, marketing and R&D collaborations

The service offers a range of benefits, including: • Access to an experienced team of analysts • Evidence-based insights using industry gold standard information assets • Tailored reports that can be used directly for executive level and third party discussions • No need for database subscriptions

Please contact your Account Manager for more information

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IMS Health Global Market Insights 2015