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LSS Urinary System

Alexandra Burke-Smith

Mechanism of acid-base balance Urinary System 7 - Dr Daqing

1. 2. 3. 4. 5. 6. 7. 8. 9.

What is the normal physiological pH range, and why is its normal value so important for life? Why is HCO3-/CO2 system so important for plasma pH? What is the definition of buffer and what do they do in our body? How do the kidneys contribute to systemic acid-base balance? What are the mechanisms for H+ excretion in kidneys How do the various segments of the nephron contribute to the process of reabsorbing the filtered HCO3-? How do the kidneys form new HCO3-? What are the major mechanisms by which the body defends itself against changes in acid-base balance? What is the difference between simple metabolic and respiratory acid-base disorders, and how are they differentiated by blood gas analysis?

Outline of lecture: basic definitions, controlled pH value + its importance, acid-base balance regulation, cellular balance system, hydrogen ion excretion, bicarbonate reabsorption, new bicarbonate formation, basic acid-base disorders, clinical implications    

Acid: a substance that can release H+ ions in solution Base: a substance that can accept H+ ions in solution Buffer: a substance which can release or accept H+ ions in solution, resulting in minimal changes to pH pH: a logarithmic measurement of H+ ion concentration; indicates acidity of the solution. pH= -log[H+] 25

Alex's Urinary  
Alex's Urinary  

Alex's Urinary